Jonathan Seidman - Publications

Affiliations: 
Harvard University, Cambridge, MA, United States 
Area:
Genetics, Molecular Biology, Human Development

170 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Toepfer CN, Garfinkel AC, Venturini G, Wakimoto H, Repetti G, Alamo L, Sharma A, Agarwal R, Ewoldt JF, Cloonan P, Letendre J, Lun M, Olivotto I, Colan S, Ashley E, ... ... Seidman JG, et al. Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy. Circulation. PMID 31983222 DOI: 10.1161/Circulationaha.119.042339  0.32
2018 Chang ACY, Chang ACH, Kirillova A, Sasagawa K, Su W, Weber G, Lin J, Termglinchan V, Karakikes I, Seeger T, Dainis AM, Hinson JT, Seidman J, Seidman CE, Day JW, et al. Telomere shortening is a hallmark of genetic cardiomyopathies. Proceedings of the National Academy of Sciences of the United States of America. PMID 30150400 DOI: 10.1073/Pnas.1714538115  0.32
2018 Chopra A, Kutys ML, Zhang K, Polacheck WJ, Sheng CC, Luu RJ, Eyckmans J, Hinson JT, Seidman JG, Seidman CE, Chen CS. Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions. Developmental Cell. 44: 87-96.e5. PMID 29316444 DOI: 10.1016/J.Devcel.2017.12.012  0.32
2017 Hinson JT, Chopra A, Lowe A, Sheng CC, Gupta RM, Kuppusamy R, O'Sullivan J, Rowe G, Wakimoto H, Gorham J, Burke MA, Zhang K, Musunuru K, Gerszten RE, Wu SM, ... ... Seidman JG, et al. Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis. Cell Reports. 19: 2410. PMID 28614725 DOI: 10.1016/j.celrep.2017.05.038  0.32
2016 Hinson JT, Chopra A, Lowe A, Sheng CC, Gupta RM, Kuppusamy R, O'Sullivan J, Rowe G, Wakimoto H, Gorham J, Zhang K, Musunuru K, Gerszten RE, Wu SM, Chen CS, ... Seidman JG, et al. Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis. Cell Reports. 17: 3292-3304. PMID 28009297 DOI: 10.1016/J.Celrep.2016.11.066  0.32
2016 Davis J, Davis LC, Correll RN, Makarewich CA, Schwanekamp JA, Moussavi-Harami F, Wang D, York AJ, Wu H, Houser SR, Seidman CE, Seidman JG, Regnier M, Metzger JM, Wu JC, et al. A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy. Cell. PMID 27114035 DOI: 10.1016/J.Cell.2016.04.002  0.48
2015 Huang ZP, Kataoka M, Chen J, Wu G, Ding J, Nie M, Lin Z, Liu J, Hu X, Ma L, Zhou B, Wakimoto H, Zeng C, Kyselovic J, Deng ZL, ... ... Seidman JG, et al. Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis. The Journal of Clinical Investigation. PMID 26436652 DOI: 10.1172/Jci82423  0.48
2015 Hinson JT, Chopra A, Nafissi N, Polacheck WJ, Benson CC, Swist S, Gorham J, Yang L, Schafer S, Sheng CC, Haghighi A, Homsy J, Hubner N, Church G, Cook SA, ... ... Seidman JG, et al. HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy. Science (New York, N.Y.). 349: 982-6. PMID 26315439 DOI: 10.1126/Science.Aaa5458  0.48
2015 Jiang J, Burgon PG, Wakimoto H, Onoue K, Gorham JM, O'Meara CC, Fomovsky G, McConnell BK, Lee RT, Seidman JG, Seidman CE. Cardiac myosin binding protein C regulates postnatal myocyte cytokinesis Proceedings of the National Academy of Sciences of the United States of America. 112: 9046-9051. PMID 26153423 DOI: 10.1073/pnas.1511004112  0.48
2015 Homsy J, Zaidi S, Shen Y, Ware JS, Samocha KE, Karczewski KJ, DePalma SR, McKean D, Wakimoto H, Gorham J, Jin SC, Deanfield J, Giardini A, Porter GA, Kim R, ... ... Seidman JG, et al. De novo mutations in congenital heart disease with neurodevelopmental and other congenital anomalies Science. 350: 1262-1266. DOI: 10.1126/science.aac9396  0.48
2014 Arad M, Monserrat L, Haron-Khun S, Seidman JG, Seidman CE, Arbustini E, Glikson M, Freimark D. Merits and pitfalls of genetic testing in a hypertrophic cardiomyopathy clinic. The Israel Medical Association Journal : Imaj. 16: 707-13. PMID 25558701  0.48
2014 Adalsteinsdottir B, Teekakirikul P, Maron BJ, Burke MA, Gudbjartsson DF, Holm H, Stefansson K, DePalma SR, Mazaika E, McDonough B, Danielsen R, Seidman JG, Seidman CE, Gunnarsson GT. Nationwide study on hypertrophic cardiomyopathy in Iceland: evidence of a MYBPC3 founder mutation. Circulation. 130: 1158-67. PMID 25078086 DOI: 10.1161/CIRCULATIONAHA.114.011207  0.48
2014 Lin Z, von Gise A, Zhou P, Gu F, Ma Q, Jiang J, Yau AL, Buck JN, Gouin KA, van Gorp PR, Zhou B, Chen J, Seidman JG, Wang DZ, Pu WT. Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model. Circulation Research. 115: 354-63. PMID 24833660 DOI: 10.1161/Circresaha.115.303632  0.48
2014 Blankenburg R, Hackert K, Wurster S, Deenen R, Seidman JG, Seidman CE, Lohse MJ, Schmitt JP. β-Myosin heavy chain variant Val606Met causes very mild hypertrophic cardiomyopathy in mice, but exacerbates HCM phenotypes in mice carrying other HCM mutations. Circulation Research. 115: 227-37. PMID 24829265 DOI: 10.1161/Circresaha.115.303178  0.48
2014 Fahed AC, McDonough B, Gouvion CM, Newell KL, Dure LS, Bebin M, Bick AG, Seidman JG, Harter DH, Seidman CE. UBQLN2 mutation causing heterogeneous X-linked dominant neurodegeneration. Annals of Neurology. 75: 793-8. PMID 24771548 DOI: 10.1002/ana.24164  0.48
2014 Kurtzwald-Josefson E, Hochhauser E, Bogachenko K, Harun-Khun S, Katz G, Aravot D, Seidman JG, Seidman CE, Eldar M, Shainberg A, Arad M. Alpha blockade potentiates CPVT therapy in calsequestrin-mutant mice. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 11: 1471-9. PMID 24768611 DOI: 10.1016/j.hrthm.2014.04.030  0.48
2014 van den Boogaard M, Smemo S, Burnicka-Turek O, Arnolds DE, van de Werken HJ, Klous P, McKean D, Muehlschlegel JD, Moosmann J, Toka O, Yang XH, Koopmann TT, Adriaens ME, Bezzina CR, de Laat W, ... ... Seidman JG, et al. A common genetic variant within SCN10A modulates cardiac SCN5A expression. The Journal of Clinical Investigation. 124: 1844-52. PMID 24642470 DOI: 10.1172/Jci73140  0.48
2014 Christodoulou DC, Wakimoto H, Onoue K, Eminaga S, Gorham JM, DePalma SR, Herman DS, Teekakirikul P, Conner DA, McKean DM, Domenighetti AA, Aboukhalil A, Chang S, Srivastava G, McDonough B, ... ... Seidman JG, et al. 5'RNA-Seq identifies Fhl1 as a genetic modifier in cardiomyopathy. The Journal of Clinical Investigation. 124: 1364-70. PMID 24509080 DOI: 10.1172/Jci70108  0.48
2014 Ito K, Bick AG, Flannick J, Friedman DJ, Genovese G, Parfenov MG, Depalma SR, Gupta N, Gabriel SB, Taylor HA, Fox ER, Newton-Cheh C, Kathiresan S, Hirschhorn JN, Altshuler DM, ... ... Seidman JG, et al. Increased burden of cardiovascular disease in carriers of APOL1 genetic variants. Circulation Research. 114: 845-50. PMID 24379297 DOI: 10.1161/Circresaha.114.302347  0.48
2014 Dai J, Matsui T, Abel ED, Dedhar S, Gerszten RE, Seidman CE, Seidman JG, Rosenzweig A. Deep sequence analysis of gene expression identifies osteopontin as a downstream effector of integrin-linked kinase (ILK) in cardiac-specific ILK knockout mice. Circulation. Heart Failure. 7: 184-93. PMID 24319095 DOI: 10.1161/Circheartfailure.113.000649  0.48
2014 Domenighetti AA, Chu PH, Wu T, Sheikh F, Gokhin DS, Guo LT, Cui Z, Peter AK, Christodoulou DC, Parfenov MG, Gorham JM, Li DY, Banerjee I, Lai X, Witzmann FA, ... ... Seidman JG, et al. Loss of FHL1 induces an age-dependent skeletal muscle myopathy associated with myofibrillar and intermyofibrillar disorganization in mice. Human Molecular Genetics. 23: 209-25. PMID 23975679 DOI: 10.1093/Hmg/Ddt412  0.48
2013 Hölter SM, Stromberg M, Kovalenko M, Garrett L, Glasl L, Lopez E, Guide J, Götz A, Hans W, Becker L, Rathkolb B, Rozman J, Schrewed A, Klingenspor M, Klopstock T, ... ... Seidman J, et al. A broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington's disease CAG knock-in mice. Plos One. 8: e80923. PMID 24278347 DOI: 10.1371/Journal.Pone.0080923  0.48
2013 Flannick J, Beer NL, Bick AG, Agarwala V, Molnes J, Gupta N, Burtt NP, Florez JC, Meigs JB, Taylor H, Lyssenko V, Irgens H, Fox E, Burslem F, Johansson S, ... ... Seidman JG, et al. Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes. Nature Genetics. 45: 1380-5. PMID 24097065 DOI: 10.1038/Ng.2794  0.48
2013 Weinstein JN, Collisson EA, Mills GB, Shaw KR, Ozenberger BA, Ellrott K, Shmulevich I, Sander C, Stuart JM. The Cancer Genome Atlas Pan-Cancer analysis project. Nature Genetics. 45: 1113-20. PMID 24071849 DOI: 10.1038/Ng.2764  0.48
2013 Katz G, Shainberg A, Hochhauser E, Kurtzwald-Josefson E, Issac A, El-Ani D, Aravot D, Afek A, Seidman JG, Seidman CE, Eldar M, Arad M. The role of mutant protein level in autosomal recessive catecholamine dependent polymorphic ventricular tachycardia (CPVT2). Biochemical Pharmacology. 86: 1576-83. PMID 24070655 DOI: 10.1016/j.bcp.2013.09.012  0.48
2013 Brown KK, Viana LM, Helwig CC, Artunduaga MA, Quintanilla-Dieck L, Jarrin P, Osorno G, McDonough B, DePalma SR, Eavey RD, Seidman JG, Seidman CE. HOXA2 haploinsufficiency in dominant bilateral microtia and hearing loss. Human Mutation. 34: 1347-51. PMID 23775976 DOI: 10.1002/humu.22367  0.48
2013 Zaidi S, Choi M, Wakimoto H, Ma L, Jiang J, Overton JD, Romano-Adesman A, Bjornson RD, Breitbart RE, Brown KK, Carriero NJ, Cheung YH, Deanfield J, DePalma S, Fakhro KA, ... ... Seidman JG, et al. De novo mutations in histone-modifying genes in congenital heart disease. Nature. 498: 220-3. PMID 23665959 DOI: 10.1038/Nature12141  0.48
2013 Costa MW, Guo G, Wolstein O, Vale M, Castro ML, Wang L, Otway R, Riek P, Cochrane N, Furtado M, Semsarian C, Weintraub RG, Yeoh T, Hayward C, Keogh A, ... ... Seidman JG, et al. Functional characterization of a novel mutation in NKX2-5 associated with congenital heart disease and adult-onset cardiomyopathy. Circulation. Cardiovascular Genetics. 6: 238-47. PMID 23661673 DOI: 10.1161/Circgenetics.113.000057  0.48
2013 Ayturk UM, Jacobsen CM, Christodoulou DC, Gorham J, Seidman JG, Seidman CE, Robling AG, Warman ML. An RNA-seq protocol to identify mRNA expression changes in mouse diaphyseal bone: applications in mice with bone property altering Lrp5 mutations. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 28: 2081-93. PMID 23553928 DOI: 10.1002/Jbmr.1946  0.48
2013 Zhang B, Day DS, Ho JW, Song L, Cao J, Christodoulou D, Seidman JG, Crawford GE, Park PJ, Pu WT. A dynamic H3K27ac signature identifies VEGFA-stimulated endothelial enhancers and requires EP300 activity. Genome Research. 23: 917-27. PMID 23547170 DOI: 10.1101/Gr.149674.112  0.48
2013 Gelb B, Brueckner M, Chung W, Goldmuntz E, Kaltman J, Kaski JP, Kim R, Kline J, Mercer-Rosa L, Porter G, Roberts A, Rosenberg E, Seiden H, Seidman C, et al. The Congenital Heart Disease Genetic Network Study: rationale, design, and early results. Circulation Research. 112: 698-706. PMID 23410879 DOI: 10.1161/Circresaha.111.300297  0.48
2013 Palmer BM, Schmitt JP, Seidman CE, Seidman JG, Wang Y, Bell SP, LeWinter MM, Maughan DW. Elevated rates of force development and MgATP binding in F764L and S532P myosin mutations causing dilated cardiomyopathy Journal of Molecular and Cellular Cardiology. 57: 23-31. PMID 23313350 DOI: 10.1016/j.yjmcc.2012.12.022  0.48
2012 Kurtzwald-Josefson E, Hochhauser E, Katz G, Porat E, Seidman JG, Seidman CE, Chepurko Y, Shainberg A, Eldar M, Arad M. Exercise training improves cardiac function and attenuates arrhythmia in CPVT mice. Journal of Applied Physiology (Bethesda, Md. : 1985). 113: 1677-83. PMID 23042908 DOI: 10.1152/japplphysiol.00818.2012  0.48
2012 Bick AG, Flannick J, Ito K, Cheng S, Vasan RS, Parfenov MG, Herman DS, DePalma SR, Gupta N, Gabriel SB, Funke BH, Rehm HL, Benjamin EJ, Aragam J, Taylor HA, ... ... Seidman JG, et al. Burden of rare sarcomere gene variants in the Framingham and Jackson Heart Study cohorts. American Journal of Human Genetics. 91: 513-9. PMID 22958901 DOI: 10.1016/J.Ajhg.2012.07.017  0.48
2012 Lage K, Greenway SC, Rosenfeld JA, Wakimoto H, Gorham JM, Segrè AV, Roberts AE, Smoot LB, Pu WT, Pereira AC, Mesquita SM, Tommerup N, Brunak S, Ballif BC, Shaffer LG, ... ... Seidman JG, et al. Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development. Proceedings of the National Academy of Sciences of the United States of America. 109: 14035-40. PMID 22904188 DOI: 10.1073/Pnas.1210730109  0.48
2012 Larman TC, DePalma SR, Hadjipanayis AG, Protopopov A, Zhang J, Gabriel SB, Chin L, Seidman CE, Kucherlapati R, Seidman JG. Spectrum of somatic mitochondrial mutations in five cancers. Proceedings of the National Academy of Sciences of the United States of America. 109: 14087-91. PMID 22891333 DOI: 10.1073/Pnas.1211502109  0.48
2012 Lakdawala NK, Funke BH, Baxter S, Cirino AL, Roberts AE, Judge DP, Johnson N, Mendelsohn NJ, Morel C, Care M, Chung WK, Jones C, Psychogios A, Duffy E, Rehm HL, ... ... Seidman JG, et al. Genetic testing for dilated cardiomyopathy in clinical practice. Journal of Cardiac Failure. 18: 296-303. PMID 22464770 DOI: 10.1016/J.Cardfail.2012.01.013  0.48
2012 He A, Ma Q, Cao J, von Gise A, Zhou P, Xie H, Zhang B, Hsing M, Christodoulou DC, Cahan P, Daley GQ, Kong SW, Orkin SH, Seidman CE, Seidman JG, et al. Polycomb repressive complex 2 regulates normal development of the mouse heart. Circulation Research. 110: 406-15. PMID 22158708 DOI: 10.1161/Circresaha.111.252205  0.48
2011 Holleboom AG, Karlsson H, Lin RS, Beres TM, Sierts JA, Herman DS, Stroes ES, Aerts JM, Kastelein JJ, Motazacker MM, Dallinga-Thie GM, Levels JH, Zwinderman AH, Seidman JG, Seidman CE, et al. Heterozygosity for a loss-of-function mutation in GALNT2 improves plasma triglyceride clearance in man. Cell Metabolism. 14: 811-8. PMID 22152306 DOI: 10.1016/J.Cmet.2011.11.005  0.48
2011 Lemaire SA, McDonald ML, Guo DC, Russell L, Miller CC, Johnson RJ, Bekheirnia MR, Franco LM, Nguyen M, Pyeritz RE, Bavaria JE, Devereux R, Maslen C, Holmes KW, Eagle K, ... ... Seidman JG, et al. Genome-wide association study identifies a susceptibility locus for thoracic aortic aneurysms and aortic dissections spanning FBN1 at 15q21.1. Nature Genetics. 43: 996-1000. PMID 21909107 DOI: 10.1038/Ng.934  0.48
2011 Christodoulou DC, Gorham JM, Herman DS, Seidman JG. Construction of normalized RNA-seq libraries for next-generation sequencing using the crab duplex-specific nuclease. Current Protocols in Molecular Biology / Edited by Frederick M. Ausubel ... [Et Al.]. Unit4.12. PMID 21472699 DOI: 10.1002/0471142727.mb0412s94  0.48
2011 Moskowitz IP, Wang J, Peterson MA, Pu WT, Mackinnon AC, Oxburgh L, Chu GC, Sarkar M, Berul C, Smoot L, Robertson EJ, Schwartz R, Seidman JG, Seidman CE. Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected] Proceedings of the National Academy of Sciences of the United States of America. 108: 4006-11. PMID 21330551 DOI: 10.1073/pnas.1019025108  0.48
2010 Chen PC, Wakimoto H, Conner D, Araki T, Yuan T, Roberts A, Seidman C, Bronson R, Neel B, Seidman JG, Kucherlapati R. Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation. The Journal of Clinical Investigation. 120: 4353-65. PMID 21041952 DOI: 10.1172/Jci43910  0.48
2010 Teekakirikul P, Eminaga S, Toka O, Alcalai R, Wang L, Wakimoto H, Nayor M, Konno T, Gorham JM, Wolf CM, Kim JB, Schmitt JP, Molkentin JD, Norris RA, Tager AM, ... ... Seidman JG, et al. Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β Journal of Clinical Investigation. 120: 3520-3529. PMID 20811150 DOI: 10.1172/Jci42028  0.48
2010 Katz G, Khoury A, Kurtzwald E, Hochhauser E, Porat E, Shainberg A, Seidman JG, Seidman CE, Lorber A, Eldar M, Arad M. Optimizing catecholaminergic polymorphic ventricular tachycardia therapy in calsequestrin-mutant mice. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 7: 1676-82. PMID 20620233 DOI: 10.1016/j.hrthm.2010.07.004  0.48
2010 Lage K, Møllgård K, Greenway S, Wakimoto H, Gorham JM, Workman CT, Bendsen E, Hansen NT, Rigina O, Roque FS, Wiese C, Christoffels VM, Roberts AE, Smoot LB, Pu WT, ... ... Seidman JG, et al. Dissecting spatio-temporal protein networks driving human heart development and related disorders. Molecular Systems Biology. 6: 381. PMID 20571530 DOI: 10.1038/Msb.2010.36  0.48
2010 Wang L, Seidman JG, Seidman CE. Narrative review: harnessing molecular genetics for the diagnosis and management of hypertrophic cardiomyopathy. Annals of Internal Medicine. 152: 513-20, W181. PMID 20404382 DOI: 10.7326/0003-4819-152-8-201004200-00008  0.48
2010 Lakdawala NK, Dellefave L, Redwood CS, Sparks E, Cirino AL, Depalma S, Colan SD, Funke B, Zimmerman RS, Robinson P, Watkins H, Seidman CE, Seidman JG, McNally EM, Ho CY. Familial dilated cardiomyopathy caused by an alpha-tropomyosin mutation: the distinctive natural history of sarcomeric dilated cardiomyopathy. Journal of the American College of Cardiology. 55: 320-9. PMID 20117437 DOI: 10.1016/J.Jacc.2009.11.017  0.48
2009 Zvaritch E, Kraeva N, Bombardier E, McCloy RA, Depreux F, Holmyard D, Kraev A, Seidman CE, Seidman JG, Tupling AR, MacLennan DH. Ca2+ dysregulation in Ryr1(I4895T/wt) mice causes congenital myopathy with progressive formation of minicores, cores, and nemaline rods. Proceedings of the National Academy of Sciences of the United States of America. 106: 21813-8. PMID 19959667 DOI: 10.1073/Pnas.0912126106  0.48
2009 Mobine HR, Baker AB, Wang L, Wakimoto H, Jacobsen KC, Seidman CE, Seidman JG, Edelman ER. Pheochromocytoma-induced cardiomyopathy is modulated by the synergistic effects of cell-secreted factors. Circulation. Heart Failure. 2: 121-8. PMID 19808327 DOI: 10.1161/Circheartfailure.108.813261  0.48
2009 Greenway SC, Pereira AC, Lin JC, DePalma SR, Israel SJ, Mesquita SM, Ergul E, Conta JH, Korn JM, McCarroll SA, Gorham JM, Gabriel S, Altshuler DM, Quintanilla-Dieck Mde L, Artunduaga MA, ... ... Seidman JG, et al. De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot. Nature Genetics. 41: 931-5. PMID 19597493 DOI: 10.1038/Ng.415  0.48
2009 Fox AA, Collard CD, Shernan SK, Seidman CE, Seidman JG, Liu KY, Muehlschlegel JD, Perry TE, Aranki SF, Lange C, Herman DS, Meitinger T, Lichtner P, Body SC. Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting. Anesthesiology. 110: 738-47. PMID 19326473 DOI: 10.1097/ALN.0b013e31819c7496  0.48
2009 Maron BJ, Roberts WC, Arad M, Haas TS, Spirito P, Wright GB, Almquist AK, Baffa JM, Saul JP, Ho CY, Seidman J, Seidman CE. Clinical outcome and phenotypic expression in LAMP2 cardiomyopathy. Jama. 301: 1253-9. PMID 19318653 DOI: 10.1001/Jama.2009.371  0.48
2009 Schmitt JP, Ahmad F, Lorenz K, Hein L, Schulz S, Asahi M, Maclennan DH, Seidman CE, Seidman JG, Lohse MJ. Alterations of phospholamban function can exhibit cardiotoxic effects independent of excessive sarcoplasmic reticulum Ca2+-ATPase inhibition. Circulation. 119: 436-44. PMID 19139388 DOI: 10.1161/Circulationaha.108.783506  0.48
2008 Wang L, Sewell WF, Kim SD, Shin JT, MacRae CA, Zon LI, Seidman JG, Seidman CE. Eya4 regulation of Na+/K+-ATPase is required for sensory system development in zebrafish. Development (Cambridge, England). 135: 3425-34. PMID 18799547 DOI: 10.1242/Dev.012237  0.48
2008 Morita H, Rehm HL, Menesses A, McDonough B, Roberts AE, Kucherlapati R, Towbin JA, Seidman JG, Seidman CE. Shared genetic causes of cardiac hypertrophy in children and adults. The New England Journal of Medicine. 358: 1899-908. PMID 18403758 DOI: 10.1056/Nejmoa075463  0.48
2008 Tsoutsman T, Kelly M, Ng DC, Tan JE, Tu E, Lam L, Bogoyevitch MA, Seidman CE, Seidman JG, Semsarian C. Severe heart failure and early mortality in a double-mutation mouse model of familial hypertrophic cardiomyopathy. Circulation. 117: 1820-31. PMID 18362229 DOI: 10.1161/CIRCULATIONAHA.107.755777  0.48
2008 Palmer BM, Wang Y, Teekakirikul P, Hinson JT, Fatkin D, Strouse S, Vanburen P, Seidman CE, Seidman JG, Maughan DW. Myofilament mechanical performance is enhanced by R403Q myosin in mouse myocardium independent of sex. American Journal of Physiology. Heart and Circulatory Physiology. 294: H1939-47. PMID 18281382 DOI: 10.1152/ajpheart.00644.2007  0.32
2008 Ofir M, Arad M, Porat E, Freimark D, Chepurko Y, Vidne BA, Seidman CE, Seidman JG, Kemp BE, Hochhauser E. Increased glycogen stores due to gamma-AMPK overexpression protects against ischemia and reperfusion damage. Biochemical Pharmacology. 75: 1482-91. PMID 18261713 DOI: 10.1016/j.bcp.2007.12.011  0.48
2008 Depreux FF, Darrow K, Conner DA, Eavey RD, Liberman MC, Seidman CE, Seidman JG. Eya4-deficient mice are a model for heritable otitis media. The Journal of Clinical Investigation. 118: 651-8. PMID 18219393 DOI: 10.1172/JCI32899  0.48
2008 Wolf CM, Wang L, Alcalai R, Pizard A, Burgon PG, Ahmad F, Sherwood M, Branco DM, Wakimoto H, Fishman GI, See V, Stewart CL, Conner DA, Berul CI, Seidman CE, ... Seidman JG, et al. Lamin A/C haploinsufficiency causes dilated cardiomyopathy and apoptosis-triggered cardiac conduction system disease. Journal of Molecular and Cellular Cardiology. 44: 293-303. PMID 18182166 DOI: 10.1016/J.Yjmcc.2007.11.008  0.48
2008 Wolf CM, Arad M, Ahmad F, Sanbe A, Bernstein SA, Toka O, Konno T, Morley G, Robbins J, Seidman JG, Seidman CE, Berul CI. Reversibility of PRKAG2 glycogen-storage cardiomyopathy and electrophysiological manifestations. Circulation. 117: 144-54. PMID 18158359 DOI: 10.1161/CIRCULATIONAHA.107.726752  0.48
2008 Gramolini AO, Kislinger T, Alikhani-Koopaei R, Fong V, Thompson NJ, Isserlin R, Sharma P, Oudit GY, Trivieri MG, Fagan A, Kannan A, Higgins DG, Huedig H, Hess G, Arab S, ... Seidman JG, et al. Comparative proteomics profiling of a phospholamban mutant mouse model of dilated cardiomyopathy reveals progressive intracellular stress responses. Molecular & Cellular Proteomics : McP. 7: 519-33. PMID 18056057 DOI: 10.1074/Mcp.M700245-Mcp200  0.48
2007 Zvaritch E, Depreux F, Kraeva N, Loy RE, Goonasekera SA, Boncompagni S, Boncompagi S, Kraev A, Gramolini AO, Dirksen RT, Franzini-Armstrong C, Seidman CE, Seidman JG, Maclennan DH. An Ryr1I4895T mutation abolishes Ca2+ release channel function and delays development in homozygous offspring of a mutant mouse line. Proceedings of the National Academy of Sciences of the United States of America. 104: 18537-42. PMID 18003898 DOI: 10.1073/Pnas.0709312104  0.48
2007 Song L, Alcalai R, Arad M, Wolf CM, Toka O, Conner DA, Berul CI, Eldar M, Seidman CE, Seidman JG. Calsequestrin 2 (CASQ2) mutations increase expression of calreticulin and ryanodine receptors, causing catecholaminergic polymorphic ventricular tachycardia. The Journal of Clinical Investigation. 117: 1814-23. PMID 17607358 DOI: 10.1172/JCI31080  0.48
2007 Moskowitz IP, Kim JB, Moore ML, Wolf CM, Peterson MA, Shendure J, Nobrega MA, Yokota Y, Berul C, Izumo S, Seidman JG, Seidman CE. A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development. Cell. 129: 1365-76. PMID 17604724 DOI: 10.1016/J.Cell.2007.04.036  0.48
2007 Luptak I, Shen M, He H, Hirshman MF, Musi N, Goodyear LJ, Yan J, Wakimoto H, Morita H, Arad M, Seidman CE, Seidman JG, Ingwall JS, Balschi JA, Tian R. Aberrant activation of AMP-activated protein kinase remodels metabolic network in favor of cardiac glycogen storage. The Journal of Clinical Investigation. 117: 1432-9. PMID 17431505 DOI: 10.1172/JCI30658  0.48
2007 Debold EP, Schmitt JP, Patlak JB, Beck SE, Moore JR, Seidman JG, Seidman C, Warshaw DM. Hypertrophic and dilated cardiomyopathy mutations differentially affect the molecular force generation of mouse alpha-cardiac myosin in the laser trap assay. American Journal of Physiology. Heart and Circulatory Physiology. 293: H284-91. PMID 17351073 DOI: 10.1152/Ajpheart.00128.2007  0.48
2007 Hinson JT, Fantin VR, Schönberger J, Breivik N, Siem G, McDonough B, Sharma P, Keogh I, Godinho R, Santos F, Esparza A, Nicolau Y, Selvaag E, Cohen BH, Hoppel CL, ... ... Seidman JG, et al. Missense mutations in the BCS1L gene as a cause of the Björnstad syndrome. The New England Journal of Medicine. 356: 809-19. PMID 17314340 DOI: 10.1056/NEJMoa055262  0.48
2007 Stroud DM, Darrow BJ, Kim SD, Zhang J, Jongbloed MR, Rentschler S, Moskowitz IP, Seidman J, Fishman GI. Complex genomic rearrangement in CCS-LacZ transgenic mice. Genesis (New York, N.Y. : 2000). 45: 76-82. PMID 17269130 DOI: 10.1002/Dvg.20267  0.48
2006 Schmitt JP, Debold EP, Ahmad F, Armstrong A, Frederico A, Conner DA, Mende U, Lohse MJ, Warshaw D, Seidman CE, Seidman JG. Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor function. Proceedings of the National Academy of Sciences of the United States of America. 103: 14525-30. PMID 16983074 DOI: 10.1073/Pnas.0606383103  0.48
2006 Mori AD, Zhu Y, Vahora I, Nieman B, Koshiba-Takeuchi K, Davidson L, Pizard A, Seidman JG, Seidman CE, Chen XJ, Henkelman RM, Bruneau BG. Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis. Developmental Biology. 297: 566-86. PMID 16870172 DOI: 10.1016/J.Ydbio.2006.05.023  0.48
2006 Morita H, Larson MG, Barr SC, Vasan RS, O'Donnell CJ, Hirschhorn JN, Levy D, Corey D, Seidman CE, Seidman JG, Benjamin EJ. Single-gene mutations and increased left ventricular wall thickness in the community: The Framingham Heart Study Circulation. 113: 2697-2705. PMID 16754800 DOI: 10.1161/Circulationaha.105.593558  0.48
2005 Wolf CM, Moskowitz IP, Arno S, Branco DM, Semsarian C, Bernstein SA, Peterson M, Maida M, Morley GE, Fishman G, Berul CI, Seidman CE, Seidman JG. Somatic events modify hypertrophic cardiomyopathy pathology and link hypertrophy to arrhythmia. Proceedings of the National Academy of Sciences of the United States of America. 102: 18123-8. PMID 16332958 DOI: 10.1073/Pnas.0509145102  0.48
2005 Arad M, Penas-Lado M, Monserrat L, Maron BJ, Sherrid M, Ho CY, Barr S, Karim A, Olson TM, Kamisago M, Seidman JG, Seidman CE. Gene mutations in apical hypertrophic cardiomyopathy. Circulation. 112: 2805-11. PMID 16267253 DOI: 10.1161/CIRCULATIONAHA.105.547448  0.48
2005 Arad M, Maron BJ, Gorham JM, Johnson WH, Saul JP, Perez-Atayde AR, Spirito P, Wright GB, Kanter RJ, Seidman CE, Seidman JG. Glycogen storage diseases presenting as hypertrophic cardiomyopathy. The New England Journal of Medicine. 352: 362-72. PMID 15673802 DOI: 10.1056/NEJMoa033349  0.48
2004 Palmer BM, McConnell BK, Li GH, Seidman CE, Seidman JG, Irving TC, Alpert NR, Maughan DW. Reduced cross-bridge dependent stiffness of skinned myocardium from mice lacking cardiac myosin binding protein-C. Molecular and Cellular Biochemistry. 263: 73-80. PMID 15524168 DOI: 10.1023/B:MCBI.0000041849.60591.45  0.48
2004 Keogh IJ, Godinho RN, Wu TP, Diaz de Palacios AM, Palacios N, Bello de Alford M, De Almada MI, MarPalacios N, Vazquez A, Mattei R, Seidman C, Seidman J, Eavey RD. Clinical and genetic linkage analysis of a large Venezuelan kindred with Usher syndrome. International Journal of Pediatric Otorhinolaryngology. 68: 1063-8. PMID 15236894 DOI: 10.1016/J.Ijporl.2004.04.005  0.48
2004 Palmer BM, Georgakopoulos D, Janssen PM, Wang Y, Alpert NR, Belardi DF, Harris SP, Moss RL, Burgon PG, Seidman CE, Seidman JG, Maughan DW, Kass DA. Role of cardiac myosin binding protein C in sustaining left ventricular systolic stiffening. Circulation Research. 94: 1249-55. PMID 15059932 DOI: 10.1161/01.Res.0000126898.95550.31  0.48
2004 Jumlongras D, Lin JY, Chapra A, Seidman CE, Seidman JG, Maas RL, Olsen BR. A novel missense mutation in the paired domain of PAX9 causes non-syndromic oligodontia. Human Genetics. 114: 242-9. PMID 14689302 DOI: 10.1007/S00439-003-1066-6  0.48
2003 Patel VV, Arad M, Moskowitz IP, Maguire CT, Branco D, Seidman JG, Seidman CE, Berul CI. Electrophysiologic characterization and postnatal development of ventricular pre-excitation in a mouse model of cardiac hypertrophy and Wolff-Parkinson-White syndrome. Journal of the American College of Cardiology. 42: 942-51. PMID 12957447 DOI: 10.1016/S0735-1097(03)00850-7  0.48
2003 Schmitt JP, Semsarian C, Arad M, Gannon J, Ahmad F, Duffy C, Lee RT, Seidman CE, Seidman JG. Consequences of pressure overload on sarcomere protein mutation-induced hypertrophic cardiomyopathy. Circulation. 108: 1133-8. PMID 12925456 DOI: 10.1161/01.CIR.0000086469.85750.48  0.48
2003 Arad M, Moskowitz IP, Patel VV, Ahmad F, Perez-Atayde AR, Sawyer DB, Walter M, Li GH, Burgon PG, Maguire CT, Stapleton D, Schmitt JP, Guo XX, Pizard A, Kupershmidt S, ... ... Seidman JG, et al. Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy. Circulation. 107: 2850-6. PMID 12782567 DOI: 10.1161/01.Cir.0000075270.13497.2B  0.48
2003 Rallis C, Bruneau BG, Del Buono J, Seidman CE, Seidman JG, Nissim S, Tabin CJ, Logan MP. Tbx5 is required for forelimb bud formation and continued outgrowth. Development (Cambridge, England). 130: 2741-51. PMID 12736217 DOI: 10.1242/Dev.00473  0.48
2003 Grabie N, Delfs MW, Westrich JR, Love VA, Stavrakis G, Ahmad F, Seidman CE, Seidman JG, Lichtman AH. IL-12 is required for differentiation of pathogenic CD8+ T cell effectors that cause myocarditis. The Journal of Clinical Investigation. 111: 671-80. PMID 12618521 DOI: 10.1172/Jci16867  0.48
2003 Schmitt JP, Kamisago M, Asahi M, Li GH, Ahmad F, Mende U, Kranias EG, MacLennan DH, Seidman JG, Seidman CE. Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban. Science (New York, N.Y.). 299: 1410-3. PMID 12610310 DOI: 10.1126/Science.1081578  0.48
2002 Morita H, DePalma SR, Arad M, McDonough B, Barr S, Duffy C, Maron BJ, Seidman CE, Seidman JG. Molecular epidemiology of hypertrophic cardiomyopathy. Cold Spring Harbor Symposia On Quantitative Biology. 67: 383-8. PMID 12858563 DOI: 10.1101/SQB.2002.67.383  0.48
2002 Tanaka M, Berul CI, Ishii M, Jay PY, Wakimoto H, Douglas P, Yamasaki N, Kawamoto T, Gehrmann J, Maguire CT, Schinke M, Seidman CE, Seidman JG, Kurachi Y, Izumo S. A mouse model of congenital heart disease: Cardiac arrhythmias and atrial septal defect caused by haploinsufficiency of the cardiac transcription factor Csx/Nkx2.5 Cold Spring Harbor Symposia On Quantitative Biology. 67: 317-325. PMID 12858555 DOI: 10.1101/Sqb.2002.67.317  0.48
2002 Huang T, Lock JE, Marshall AC, Basson C, Seidman JG, Seidman CE. Causes of clinical diversity in human TBX5 mutations Cold Spring Harbor Symposia On Quantitative Biology. 67: 115-120. PMID 12858531 DOI: 10.1101/sqb.2002.67.115  0.48
2002 Semsarian C, Ahmad I, Giewat M, Georgakopoulos D, Schmitt JP, McConnell BK, Reiken S, Mende U, Marks AR, Kass DA, Seidman CE, Seidman JG. The L-type calcium channel inhibitor diltiazem prevents cardiomyopathy in a mouse model. The Journal of Clinical Investigation. 109: 1013-20. PMID 11956238 DOI: 10.1172/Jci200214677  0.48
2002 Arad M, Benson DW, Perez-Atayde AR, McKenna WJ, Sparks EA, Kanter RJ, McGarry K, Seidman JG, Seidman CE. Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy. The Journal of Clinical Investigation. 109: 357-62. PMID 11827995 DOI: 10.1172/JCI14571  0.48
2001 Bruneau BG, Nemer G, Schmitt JP, Charron F, Robitaille L, Caron S, Conner DA, Gessler M, Nemer M, Seidman CE, Seidman JG. A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease. Cell. 106: 709-21. PMID 11572777 DOI: 10.1016/S0092-8674(01)00493-7  0.48
2001 Maron BJ, Niimura H, Casey SA, Soper MK, Wright GB, Seidman JG, Seidman CE. Development of left ventricular hypertrophy in adults with hypertrophic cardiomyopathy caused by cardiac myosin-binding protein C gene mutations Journal of the American College of Cardiology. 38: 315-321. PMID 11499718 DOI: 10.1016/S0735-1097(01)01386-9  0.48
2001 Jumlongras D, Bei M, Stimson JM, Wang WF, DePalma SR, Seidman CE, Felbor U, Maas R, Seidman JG, Olsen BR. A nonsense mutation in MSX1 causes Witkop syndrome. American Journal of Human Genetics. 69: 67-74. PMID 11369996 DOI: 10.1086/321271  0.48
2001 Bruneau BG, Bao ZZ, Fatkin D, Xavier-Neto J, Georgakopoulos D, Maguire CT, Berul CI, Kass DA, Kuroski-de Bold ML, de Bold AJ, Conner DA, Rosenthal N, Cepko CL, Seidman CE, Seidman JG. Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression. Molecular and Cellular Biology. 21: 1730-6. PMID 11238910 DOI: 10.1128/Mcb.21.5.1730-1736.2001  0.48
2001 Encinas JA, Lees MB, Sobel RA, Symonowicz C, Weiner HL, Seidman CE, Seidman JG, Kuchroo VK. Identification of genetic loci associated with paralysis, inflammation and weight loss in mouse experimental autoimmune encephalomyelitis. International Immunology. 13: 257-64. PMID 11222494 DOI: 10.1093/Intimm/13.3.257  0.48
2000 Bruneau BG, Bao ZZ, Tanaka M, Schott JJ, Izumo S, Cepko CL, Seidman JG, Seidman CE. Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand. Developmental Biology. 217: 266-77. PMID 10625552 DOI: 10.1006/Dbio.1999.9548  0.48
1999 Benson DW, Silberbach GM, Kavanaugh-McHugh A, Cottrill C, Zhang Y, Riggs S, Smalls O, Johnson MC, Watson MS, Seidman JG, Seidman CE, Plowden J, Kugler JD. Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways. The Journal of Clinical Investigation. 104: 1567-73. PMID 10587520 DOI: 10.1172/JCI8154  0.48
1999 Fatkin D, MacRae C, Sasaki T, Wolff MR, Porcu M, Frenneaux M, Atherton J, Vidaillet HJ, Spudich S, De Girolami U, Seidman JG, Seidman C, Muntoni F, Müehle G, Johnson W, et al. Missense mutations in the rod domain of the lamin A/C gene as causes of dilated cardiomyopathy and conduction-system disease. The New England Journal of Medicine. 341: 1715-24. PMID 10580070 DOI: 10.1056/Nejm199912023412302  0.48
1999 McConnell BK, Jones KA, Fatkin D, Arroyo LH, Lee RT, Aristizabal O, Turnbull DH, Georgakopoulos D, Kass D, Bond M, Niimura H, Schoen FJ, Conner D, Fischman DA, Seidman CE, ... Seidman JG, et al. Dilated cardiomyopathy in homozygous myosin-binding protein-C mutant mice. The Journal of Clinical Investigation. 104: 1235-44. PMID 10545522 DOI: 10.1172/Jci7377  0.48
1999 Bruneau BG, Logan M, Davis N, Levi T, Tabin CJ, Seidman JG, Seidman CE. Chamber-specific cardiac expression of Tbx5 and heart defects in Holt-Oram syndrome. Developmental Biology. 211: 100-8. PMID 10373308 DOI: 10.1006/Dbio.1999.9298  0.48
1999 Bamshad M, Le T, Watkins WS, Dixon ME, Kramer BE, Roeder AD, Carey JC, Root S, Schinzel A, Van Maldergem L, Gardner RJ, Lin RC, Seidman CE, Seidman JG, Wallerstein R, et al. The spectrum of mutations in TBX3: Genotype/Phenotype relationship in ulnar-mammary syndrome. American Journal of Human Genetics. 64: 1550-62. PMID 10330342 DOI: 10.1086/302417  0.48
1999 Kim SJ, Iizuka K, Kelly RA, Geng YJ, Bishop SP, Yang G, Kudej A, McConnell BK, Seidman CE, Seidman JG, Vatner SF. An alpha-cardiac myosin heavy chain gene mutation impairs contraction and relaxation function of cardiac myocytes. The American Journal of Physiology. 276: H1780-7. PMID 10330263 DOI: 10.1152/ajpheart.1999.276.5.H1780  0.48
1999 Zhuo M, Zhang W, Son H, Mansuy I, Sobel RA, Seidman J, Kandel ER. A selective role of calcineurin aalpha in synaptic depotentiation in hippocampus. Proceedings of the National Academy of Sciences of the United States of America. 96: 4650-5. PMID 10200317 DOI: 10.1073/Pnas.96.8.4650  0.48
1999 Siu BL, Niimura H, Osborne JA, Fatkin D, MacRae C, Solomon S, Benson DW, Seidman JG, Seidman CE. Familial dilated cardiomyopathy locus maps to chromosome 2q31. Circulation. 99: 1022-6. PMID 10051295 DOI: 10.1161/01.Cir.99.8.1022  0.48
1999 Bao ZZ, Bruneau BG, Seidman JG, Seidman CE, Cepko CL. Regulation of chamber-specific gene expression in the developing heart by Irx4. Science (New York, N.Y.). 283: 1161-4. PMID 10024241 DOI: 10.1126/Science.283.5405.1161  0.48
1999 Fatkin D, Christe ME, Aristizabal O, McConnell BK, Srinivasan S, Schoen FJ, Seidman CE, Turnbull DH, Seidman JG. Neonatal cardiomyopathy in mice homozygous for the Arg403Gln mutation in the alpha cardiac myosin heavy chain gene. The Journal of Clinical Investigation. 103: 147-53. PMID 9884344 DOI: 10.1172/Jci4631  0.48
1998 Niimura H, Bachinski LL, Sangwatanaroj S, Watkins H, Chudley AE, Mckenna W, Kristinsson A, Roberts R, Sole M, Maron BJ, Seidman JG, Seidman CE, Thierfelder L, Jarcho JA, Anastasakis A, et al. Mutations in the gene for cardiac myosin-binding protein C and late- onset familial hypertrophic cardiomyopathy New England Journal of Medicine. 338: 1248-1257. PMID 9562578 DOI: 10.1056/NEJM199804303381802  0.48
1998 Spindler M, Saupe KW, Christe ME, Sweeney HL, Seidman CE, Seidman JG, Ingwall JS. Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy. The Journal of Clinical Investigation. 101: 1775-83. PMID 9541509 DOI: 10.1172/JCI1940  0.48
1998 Mathis BJ, Kim SH, Calabrese K, Haas M, Seidman JG, Seidman CE, Pollak MR. A locus for inherited focal segmental glomerulosclerosis maps to chromosome 19q13: Rapid communication Kidney International. 53: 282-286. PMID 9461087 DOI: 10.1046/J.1523-1755.1998.00828.X  0.48
1997 Kayyali US, Zhang W, Yee AG, Seidman JG, Potter H. Cytoskeletal changes in the brains of mice lacking calcineurin A alpha. Journal of Neurochemistry. 68: 1668-78. PMID 9084440 DOI: 10.1046/J.1471-4159.1997.68041668.X  0.48
1995 Brown EM, Pollak M, Chou YH, Seidman CE, Seidman JG, Hebert SC. Cloning and functional characterization of extracellular Ca2+-sensing receptors from parathyroid and kidney Bone. 17. PMID 8579901 DOI: 10.1016/8756-3282(95)00199-N  0.48
1995 Brown EM, Pollak M, Seidman CE, Seidman JG, Chou YHW, Riccardi D, Hebert SC. Calcium-ion-sensing cell-surface receptors New England Journal of Medicine. 333: 234-240. PMID 7791841 DOI: 10.1056/Nejm199507273330407  0.48
1995 Brown EM, Pollak M, Chou YHW, Seidman CE, Seidman JG, Hebert SC. The cloning of extracellular Ca2+-sensing receptors from parathyroid and kidney: Molecular mechanisms of extracellular Ca2+-sensing Journal of Nutrition. 125. PMID 7602378 DOI: 10.1093/Jn/125.Suppl_7.1965S  0.48
1995 Hendrickson BA, Conner DA, Ladd DJ, Kendall D, Casanova JE, Corthesy B, Max EE, Neutra MR, Seidman CE, Seidman JG. Altered hepatic transport of immunoglobulin A in mice lacking the J chain Journal of Experimental Medicine. 182: 1905-1911. PMID 7500036 DOI: 10.1084/jem.182.6.1905  0.48
1995 Ho C, Conner DA, Pollak MR, Ladd DJ, Kifor O, Warren HB, Brown EM, Seidman JG, Seidman CE. A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism Nature Genetics. 11: 389-394. PMID 7493018 DOI: 10.1038/Ng1295-389  0.48
1994 Straceski AJ, Geisterfer-Lowrance A, Seidman CE, Seidman JG, Leinwand LA. Functional analysis of myosin missense mutations in familial hypertrophic cardiomyopathy Proceedings of the National Academy of Sciences of the United States of America. 91: 589-593. PMID 8290568 DOI: 10.1073/Pnas.91.2.589  0.48
1994 Kuchroo VK, Collins M, al-Sabbagh A, Sobel RA, Whitters MJ, Zamvil SS, Dorf ME, Hafler DA, Seidman JG, Weiner HL. T cell receptor (TCR) usage determines disease susceptibility in experimental autoimmune encephalomyelitis: studies with TCR V beta 8.2 transgenic mice. The Journal of Experimental Medicine. 179: 1659-64. PMID 8163944 DOI: 10.1084/Jem.179.5.1659  0.48
1993 Pollak MR, Brown EM, Chou YHW, Hebert SC, Marx SJ, Stelnmann B, Levi T, Seidman CE, Seidman JG. Mutations in the human Ca2+-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism Cell. 75: 1297-1303. PMID 7916660 DOI: 10.1016/0092-8674(93)90617-Y  0.48
1992 Watkins H, Rosenzweig A, Hwang DS, Levi T, McKenna W, Seidman CE, Seidman JG. Characteristics and prognostic implications of myosin missense mutations in familial hypertrophic cardiomyopathy. The New England Journal of Medicine. 326: 1108-14. PMID 1552912 DOI: 10.1056/NEJM199204233261703  0.48
1990 Near RI, Ng SC, Mudgett-Hunter M, Hudson NW, Margolies MN, Seidman JG, Haber E, Jacobson MA. Heavy and light chain contributions to antigen binding in an anti-digoxin chain recombinant antibody produced by transfection of cloned anti-digoxin antibody genes. Molecular Immunology. 27: 901-9. PMID 2120577 DOI: 10.1016/0161-5890(90)90157-U  0.48
1990 Szyf M, Milstone DS, Schimmer BP, Parker KL, Seidman JG. cis modification of the steroid 21-hydroxylase gene prevents its expression in the Y1 mouse adrenocortical tumor cell line. Molecular Endocrinology (Baltimore, Md.). 4: 1144-52. PMID 1705655 DOI: 10.1210/Mend-4-8-1144  0.48
1990 Wucherpfennig KW, Ota K, Endo N, Seidman JG, Rosenzweig A, Weiner HL, Hafler DA. Shared human T cell receptor V beta usage to immunodominant regions of myelin basic protein. Science (New York, N.Y.). 248: 1016-9. PMID 1693015 DOI: 10.1126/Science.1693015  0.48
1988 Hochstenbach F, Parker C, McLean J, Gieselmann V, Band H, Bank I, Chess L, Spits H, Strominger JL, Seidman JG. Characterization of a third form of the human T cell receptor gamma/delta. The Journal of Experimental Medicine. 168: 761-76. PMID 3261778 DOI: 10.1084/jem.168.2.761  0.48
1987 Schnee JM, Runge MS, Matsueda GR, Hudson NW, Seidman JG, Haber E, Quertermous T. Construction and expression of a recombinant antibody-targeted plasminogen activator. Proceedings of the National Academy of Sciences of the United States of America. 84: 6904-8. PMID 3116546 DOI: 10.1073/Pnas.84.19.6904  0.48
1987 Goorha R, Bunin N, Mirro J, Murphy SB, Cross AH, Behm FG, Quertermous T, Seidman J, Kitchingman GR. Provocative pattern of rearrangements of the genes for the gamma and beta chains of the T-cell receptor in human leukemias. Proceedings of the National Academy of Sciences of the United States of America. 84: 4547-51. PMID 2955409 DOI: 10.1073/Pnas.84.13.4547  0.48
1987 González-Sarmiento R, LeBien TW, Bradley JG, Greenberg JM, Seidman JG, Ang S, Kersey JH. Acute leukemia expressing the gamma gene product of the putative second T cell receptor Journal of Clinical Investigation. 79: 1281-1284. PMID 2435758 DOI: 10.1172/Jci112949  0.48
1987 Lee SJ, Benjamin D, Duby A, Ang S, Seidman J, Hafler DA. T-cell receptor-γ-chain clones with natural killer-like activity in the cerebrospinal fluid Journal of Neuroimmunology. 16: 103. DOI: 10.1016/0165-5728(87)90287-6  0.36
1986 Brenner MB, McLean J, Dialynas DP, Strominger JL, Smith JA, Owen FL, Seidman JG, Ip S, Rosen F, Krangel MS. Identification of a putative second T-cell receptor. Nature. 322: 145-9. PMID 3755221 DOI: 10.1038/322145A0  0.48
1986 Fronek Z, Lentz D, Berliner N, Duby AD, Klein KA, Seidman JG, Schur PH. Systemic lupus erythematosus is not genetically linked to the beta chain of the T cell receptor. Arthritis and Rheumatism. 29: 1023-5. PMID 3741512 DOI: 10.1002/Art.1780290812  0.48
1986 Chaplin DD, Galbraith LJ, Seidman JG, White PC, Parker KL. Nucleotide sequence analysis of murine 21-hydroxylase genes: mutations affecting gene expression. Proceedings of the National Academy of Sciences of the United States of America. 83: 9601-5. PMID 3491986 DOI: 10.1073/pnas.83.24.9601  0.48
1986 Leiden JM, Dialynas DP, Duby AD, Murre C, Seidman J, Strominger JL. Rearrangement and expression of T-cell antigen receptor genes in human T-lymphocyte tumor lines and normal human T-cell clones: evidence for allelic exclusion of Ti beta gene expression and preferential use of a J beta 2 gene segment. Molecular and Cellular Biology. 6: 3207-14. PMID 3491297 DOI: 10.1128/Mcb.6.9.3207  0.48
1986 Murre C, Parker KC, Reiss CS, Driller JP, Wiley DC, Burakoff SJ, Seidman JG. Biochemical and functional analyses of a secreted H-2Ld molecule. Molecular and Cellular Biology. 6: 1315-9. PMID 3491290 DOI: 10.1128/Mcb.6.4.1315  0.48
1986 Dialynas DP, Murre C, Quertermous T, Boss JM, Leiden JM, Seidman JG, Strominger JL. Cloning and sequence analysis of complementary DNA encoding an aberrantly rearranged human T-cell gamma chain. Proceedings of the National Academy of Sciences of the United States of America. 83: 2619-23. PMID 3458221 DOI: 10.1073/Pnas.83.8.2619  0.48
1986 Quertermous T, Strauss W, Murre C, Dialynas DP, Strominger JL, Seidman JG. Human T-cell γ genes contain N segments and have marked junctional variability Nature. 322: 184-187. PMID 3453106 DOI: 10.1038/322184A0  0.48
1986 Owen FL, Strauss WM, Murre C, Duby AD, Hiai H, Seidman JG. AKR murine thymic leukemias are from a distinct thymic cell lineage and do not express the β chain of the T-cell antigen receptor Proceedings of the National Academy of Sciences of the United States of America. 83: 7434-7437. PMID 3094008 DOI: 10.1073/Pnas.83.19.7434  0.48
1986 Quertermous T, Murre C, Dialynas D, Duby AD, Strominger JL, Waldman TA, Seidman JG. Human T-cell γ chain genes: Organization, diversity, and rearrangement Science. 231: 252-255. PMID 3079918 DOI: 10.1126/Science.3079918  0.48
1986 Parker KL, Chaplin DD, Wong M, Seidman JG, Schimmer BP. Molecular analysis of 21-hydroxylase gene expression in mouse adrenal cells. Endocrine Research. 12: 409-27. PMID 2435543 DOI: 10.3109/07435808609035448  0.48
1985 Murre C, Waldmann RA, Morton CC, Bongiovanni KF, Waldmann TA, Shows TB, Seidman JG. Human γ-chain genes are rearranged in leukaemic T cells and map to the short arm of chromosome 7 Nature. 316: 549-552. PMID 3875797 DOI: 10.1038/316549A0  0.48
1985 Ben-Nun A, Strauss W, Leeman SA, Cohn LE, Murre C, Duby A, Seidman JG, Glimcher LH. An Ia-positive mouse T-cell clone is functional in presenting antigen to other T cells. Immunogenetics. 22: 123-30. PMID 3875550 DOI: 10.1007/Bf00563509  0.48
1985 Duby AD, Klein KA, Murre C, Seidman JG. A novel mechanism of somatic rearrangement predicted by a human T-cell antigen receptor beta-chain complementary DNA. Science (New York, N.Y.). 228: 1204-6. PMID 3839095 DOI: 10.1126/Science.3839095  0.48
1985 Seidman CE, Bloch KD, Zisfein J, Smith JA, Haber E, Homcy C, Duby AD, Choi E, Graham RM, Seidman JG. Molecular studies of the atrial natriuretic factor gene. Hypertension. 7: I31-4. PMID 3158606 DOI: 10.1161/01.Hyp.7.3_Pt_2.I31  0.48
1985 Berliner N, Duby AD, Morton CC, Leder P, Seidman JG. Detection of a frequent restriction fragment length polymorphism in the human T cell antigen receptor beta chain locus. A potential diagnostic tool. The Journal of Clinical Investigation. 76: 1283-5. PMID 2995449 DOI: 10.1172/Jci112086  1
1984 Ben-Nun A, Glimcher LH, Weis J, Seidman JG. Functional expression of a cloned I-Aβk gene in B-lymphoma cells Science. 223: 825-828. PMID 6420890 DOI: 10.1126/Science.6420890  0.48
1984 Murre C, Reiss CS, Bernabeu C, Chen LB, Burakoff SJ, Seidman JG. Construction, expression and recognition of an H - 2 molecule lacking its carboxyl terminus Nature. 307: 432-436. PMID 6363940 DOI: 10.1038/307432A0  0.48
1984 Seidman CE, Duby AD, Choi E, Graham RM, Haber E, Homcy C, Smith JA, Seidman JG. The structure of rat preproatrial natriuretic factor as defined by a complementary DNA clone. Science (New York, N.Y.). 225: 324-6. PMID 6234658 DOI: 10.1126/Science.6234658  0.48
1983 Roux-Dosseto M, Auffray C, Lillie JW, Boss JM, Cohen D, DeMars R, Mawas C, Seidman JG, Strominger JL. Genetic mapping of a human class II antigen beta-chain cDNA clone to the SB region of the HLA complex. Proceedings of the National Academy of Sciences of the United States of America. 80: 6036-40. PMID 6310612 DOI: 10.1073/Pnas.80.19.6036  0.48
1983 Margulies DH, Parnes JR, Johnson NA, Seidman JG. Linkage of β2-microglobulin and ly-m11 by molecular cloning and DNA-mediated gene transfer Proceedings of the National Academy of Sciences of the United States of America. 80: 2328-2331. PMID 6188162 DOI: 10.1073/pnas.80.8.2328  0.48
1983 Ozato K, Evans GA, Shykind B, Margulies DH, Seidman JG. Hybrid H-2 histocompatibility gene products assign domains recognized by alloreactive T cells Proceedings of the National Academy of Sciences of the United States of America. 80: 2040-2043. PMID 6188160 DOI: 10.1073/Pnas.80.7.2040  0.48
1983 Auffray C, Ben-Nun A, Roux-Dosseto M, Germain R, Seidman J, Strominger J. Polymorphism and complexity of the human DC and murine I-A alpha chain genes. The Embo Journal. 2: 121-124. DOI: 10.1002/J.1460-2075.1983.Tb01392.X  0.36
1982 Margulies DH, Evans GA, Flaherty L, Seidman JG. H-2-like genes in the Tla region of mouse chromosome 17. Nature. 295: 168-70. PMID 6276757 DOI: 10.1038/295168a0  0.48
1982 Evans GA, Margulies DH, Shykind B, Seidman JG, Ozato K. Exon shuffling: Mapping polymorphic determinants on hybrid mouse transplantation antigens Nature. 300: 755-757. PMID 6184620 DOI: 10.1038/300755A0  0.48
1981 Leder P, Max EE, Seidman JG, Kwan SP, Scharff M, Nau M, Norman B. Recombination events that activate, diversify, and delete immunoglobulin genes. Cold Spring Harbor Symposia On Quantitative Biology. 45: 859-65. PMID 6790218 DOI: 10.1101/Sqb.1981.045.01.103  1
1981 Kwan SP, Rudikoff S, Seidman JG, Leder P, Scharff MD. Nucleic acid and protein sequences of phosphocholine-binding light chains. The Journal of Experimental Medicine. 153: 1366-70. PMID 6788890 DOI: 10.1084/Jem.153.5.1366  0.4
1980 Seidman JG, Nau MM, Norman B, Kwan SP, Scharff M, Leder P. Immunoglobulin V/J recombination is accompanied by deletion of joining site and variable region segments. Proceedings of the National Academy of Sciences of the United States of America. 77: 6022-6. PMID 6777777 DOI: 10.1073/Pnas.77.10.6022  1
1980 Seidman JG, Leder P. A mutant immunoglobulin light chain is formed by aberrant DNA- and RNA-splicing events. Nature. 286: 779-83. PMID 6772973 DOI: 10.1038/286779a0  1
1980 Obata M, Yamawaki-Kataoka Y, Takahashi N, Kataoka T, Shimizu A, Mano Y, Seidman JG, Peterlin BM, Leder P, Honjo T. Immunoglobulin gamma 1 heavy chain gene: structural gene sequences cloned in a bacterial plasmid. Gene. 9: 87-97. PMID 6769752 DOI: 10.1016/0378-1119(80)90168-7  1
1980 Perry RP, Kelley DE, Coleclough C, Seidman JG, Leder P, Tonegawa S, Matthyssens G, Weigert M. Transcription of mouse kappa chain genes: implications for allelic exclusion. Proceedings of the National Academy of Sciences of the United States of America. 77: 1937-41. PMID 6769117 DOI: 10.1073/Pnas.77.4.1937  0.48
1979 Max EE, Seidman JG, Leder P. Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene. Proceedings of the National Academy of Sciences of the United States of America. 76: 3450-4. PMID 115000 DOI: 10.1073/pnas.76.7.3450  1
1978 Polsky F, Edgell MH, Seidman JG, Leder P. High capacity gel preparative electrophoresis for purification of fragments of genomic DNA. Analytical Biochemistry. 87: 397-410. PMID 686360 DOI: 10.1016/0003-2697(78)90689-9  1
1978 McClain WH, Seidman JG, Schmidt FJ. Evolution of the biosynthesis of 3′-terminal C-C-A residues in T-even bacteriophage transfer RNAs Journal of Molecular Biology. 119: 519-536. PMID 642000 DOI: 10.1016/0022-2836(78)90200-0  0.4
1978 Leder A, Miller HI, Hamer DH, Seidman JG, Norman B, Sullivan M, Leder P. Comparison of cloned mouse alpha- and beta-globin genes: conservation of intervening sequence locations and extragenic homology. Proceedings of the National Academy of Sciences of the United States of America. 75: 6187-91. PMID 282635 DOI: 10.1073/pnas.75.12.6187  1
1978 Seidman JG, Leder A, Edgell MH, Polsky F, Tilghman SM, Tiemeier DC, Leder P. Multiple related immunoglobulin variable-region genes identified by cloning and sequence analysis. Proceedings of the National Academy of Sciences of the United States of America. 75: 3881-5. PMID 279004 DOI: 10.1073/Pnas.75.8.3881  0.48
1978 Leder P, Tilghman SM, Tiemeier DC, Polsky FI, Seidman JG, Edgell MH, Enquist LW, Leder A, Norman B. The cloning of mouse globin and surrounding gene sequences in bacteriophage lambda. Cold Spring Harbor Symposia On Quantitative Biology. 42: 915-20. PMID 277326 DOI: 10.1101/Sqb.1978.042.01.093  0.48
1978 Tilghman SM, Tiemeier DC, Seidman JG, Peterlin BM, Sullivan M, Maizel JV, Leder P. Intervening sequence of DNA identified in the structural portion of a mouse beta-globin gene. Proceedings of the National Academy of Sciences of the United States of America. 75: 725-9. PMID 273235 DOI: 10.1073/Pnas.75.2.725  0.48
1978 Seidman JG, Leder P. The arrangement and rearrangement of antibody genes. Nature. 276: 790-5. PMID 103004 DOI: 10.1038/276790a0  1
1978 Seidman JG, Leder A, Nau M, Norman B, Leder P. Antibody diversity. Science (New York, N.Y.). 202: 11-7. PMID 99815 DOI: 10.1126/science.99815  1
1977 Leder P, Honjo T, Seidman J, Swan D. Origin of immunoglobulin gene diversity: the evidence and a restriction-modification model. Cold Spring Harbor Symposia On Quantitative Biology. 41: 855-62. PMID 408082 DOI: 10.1101/Sqb.1977.041.01.095  1
1977 Tilghman SM, Tiemeier DC, Polsky F, Edgell MH, Seidman JG, Leder A, Enquist LW, Norman B, Leder P. Cloning specific segments of the mammalian genome: bacteriophage lambda containing mouse globin and surrounding gene sequences. Proceedings of the National Academy of Sciences of the United States of America. 74: 4406-10. PMID 270684 DOI: 10.1073/Pnas.74.10.4406  0.48
1975 Seidman JG, Schmidt FJ, Foss K, McClain WH. A mutant of escherichia coli defective in removing 3′ terminal nucleotides from some transfer RNA precursor molecules Cell. 5: 389-400. PMID 1098779 DOI: 10.1016/0092-8674(75)90058-6  0.4
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