Iva Susan Greenwald - Publications

Affiliations: 
Genetics and Development Columbia University, New York, NY 
Area:
Genetics, Molecular Biology, Human Development
Website:
http://biology.columbia.edu/people/greenwald

86 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 O'Keeffe C, Greenwald I. EGFR signal transduction is downregulated in C. elegans vulval precursor cells during dauer diapause. Development (Cambridge, England). 149. PMID 36227589 DOI: 10.1242/dev.201094  0.321
2022 Shaffer JM, Greenwald I. SALSA, a genetically encoded biosensor for spatiotemporal quantification of Notch signal transduction in vivo. Developmental Cell. 57: 930-944.e6. PMID 35413239 DOI: 10.1016/j.devcel.2022.03.008  0.359
2022 Benavidez JM, Kim JH, Greenwald I. Influences of HLH-2 stability on anchor cell fate specification during Caenorhabditis elegans gonadogenesis. G3 (Bethesda, Md.). PMID 35134193 DOI: 10.1093/g3journal/jkac028  0.303
2021 Littleford HE, Kiontke K, Fitch DHA, Greenwald I. hlh-12, a gene that is necessary and sufficient to promote migration of gonadal regulatory cells in Caenorhabditis elegans, evolved within the Caenorhabditis clade. Genetics. 219. PMID 34740245 DOI: 10.1093/genetics/iyab127  0.327
2020 de la Cova CC, Townley R, Greenwald I. Negative feedback by conserved kinases patterns degradation of Raf in vulval fate patterning. Development (Cambridge, England). PMID 33144396 DOI: 10.1242/dev.195941  0.794
2020 Luo KL, Underwood RS, Greenwald I. Positive autoregulation of in response to LIN-12 activation in cell fate decisions during reproductive system development. Development (Cambridge, England). PMID 32839181 DOI: 10.1242/Dev.193482  0.458
2019 Deng Y, Luo KL, Shaye DD, Greenwald I. A Screen of the Conserved Kinome for Negative Regulators of LIN-12 Negative Regulatory Region ("NRR")-Missense Activity in . G3 (Bethesda, Md.). PMID 31519743 DOI: 10.1534/G3.119.400471  0.828
2019 Attner MA, Keil W, Benavidez JM, Greenwald I. HLH-2/E2A Expression Links Stochastic and Deterministic Elements of a Cell Fate Decision during C. elegans Gonadogenesis. Current Biology : Cb. 29: 3094-3100.e4. PMID 31402303 DOI: 10.1016/J.Cub.2019.07.062  0.388
2019 Tenen CC, Greenwald I. Cell Non-autonomous Function of daf-18/PTEN in the Somatic Gonad Coordinates Somatic Gonad and Germline Development in C. elegans Dauer Larvae. Current Biology : Cb. 29: 1064-1072.e8. PMID 30827916 DOI: 10.1016/J.Cub.2019.01.076  0.46
2018 Kim W, Underwood RS, Greenwald I, Shaye DD. OrthoList 2: A New Comparative Genomic Analysis of Human and Genes. Genetics. PMID 30120140 DOI: 10.1534/Genetics.118.301307  0.766
2017 Underwood R, Deng Y, Greenwald I. Integration of EGFR and LIN-12/Notch Signaling by LIN-1/Elk1, the Cdk8 Kinase Module, and SUR-2/Med23 in Vulval Precursor Cell Fate Patterning in Caenorhabditis elegans. Genetics. PMID 28954762 DOI: 10.1534/Genetics.117.300192  0.507
2017 de la Cova C, Townley R, Regot S, Greenwald I. A Real-Time Biosensor for ERK Activity Reveals Signaling Dynamics during C. elegans Cell Fate Specification. Developmental Cell. PMID 28826819 DOI: 10.1016/J.Devcel.2017.07.014  0.814
2017 Sallee MD, Littleford HE, Greenwald I. A bHLH Code for Sexually Dimorphic Form and Function of the C. elegans Somatic Gonad. Current Biology : Cb. PMID 28602651 DOI: 10.1016/J.Cub.2017.05.059  0.385
2016 Shaye DD, Greenwald I. A network of conserved formins, regulated by the guanine exchange factor EXC-5/FGD and the GTPase Cdc42, modulates tubulogenesis in vivo. Development (Cambridge, England). PMID 27697907 DOI: 10.1242/Dev.141861  0.797
2016 Deng Y, Greenwald I. Determinants in the LIN-12/Notch Intracellular Domain That Govern Its Activity and Stability During Caenorhabditis elegans Vulval Development. G3 (Bethesda, Md.). PMID 27646703 DOI: 10.1534/G3.116.034363  0.44
2015 Sallee MD, Greenwald I. Dimerization-driven degradation of C. elegans and human E proteins. Genes & Development. 29: 1356-61. PMID 26159995 DOI: 10.1101/Gad.261917.115  0.43
2015 Shaye DD, Greenwald I. The disease-associated formin INF2/EXC-6 organizes lumen and cell outgrowth during tubulogenesis by regulating F-actin and microtubule cytoskeletons. Developmental Cell. 32: 743-55. PMID 25771894 DOI: 10.1016/J.Devcel.2015.01.009  0.775
2015 Chen Y, Greenwald I. hecd-1 modulates notch activity in Caenorhabditis elegans. G3 (Bethesda, Md.). 5: 353-9. PMID 25552605 DOI: 10.1534/G3.114.015321  0.529
2014 Shaye DD, Greenwald I. Correction: OrthoList: A Compendium of C. elegans Genes with Human Orthologs Plos One. 9. DOI: 10.1371/Annotation/F5Ffb738-A176-4A43-B0E0-249Cdea45Fe0  0.754
2013 Greenwald I, Kovall R. Notch signaling: genetics and structure. Wormbook : the Online Review of C. Elegans Biology. 1-28. PMID 23355521 DOI: 10.1895/Wormbook.1.10.2  0.476
2013 Karp X, Greenwald I. Control of cell-fate plasticity and maintenance of multipotency by DAF-16/FoxO in quiescent Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 110: 2181-6. PMID 23341633 DOI: 10.1073/Pnas.1222377110  0.791
2012 de la Cova C, Greenwald I. SEL-10/Fbw7-dependent negative feedback regulation of LIN-45/Braf signaling in C. elegans via a conserved phosphodegron. Genes & Development. 26: 2524-35. PMID 23154983 DOI: 10.1101/Gad.203703.112  0.813
2012 Greenwald I. Notch and the awesome power of genetics. Genetics. 191: 655-69. PMID 22785620 DOI: 10.1534/Genetics.112.141812  0.436
2011 Shaye DD, Greenwald I. OrthoList: a compendium of C. elegans genes with human orthologs. Plos One. 6: e20085. PMID 21647448 DOI: 10.1371/Journal.Pone.0020085  0.775
2011 Zhang X, Greenwald I. Spatial regulation of lag-2 transcription during vulval precursor cell fate patterning in Caenorhabditis elegans. Genetics. 188: 847-58. PMID 21596897 DOI: 10.1534/Genetics.111.128389  0.464
2010 Li J, Greenwald I. LIN-14 inhibition of LIN-12 contributes to precision and timing of C. elegans vulval fate patterning. Current Biology : Cb. 20: 1875-9. PMID 20951046 DOI: 10.1016/J.Cub.2010.09.055  0.566
2010 Choi MS, Yoo AS, Greenwald I. sel-11 and cdc-42, two negative modulators of LIN-12/Notch activity in C. elegans. Plos One. 5: e11885. PMID 20686701 DOI: 10.1371/Journal.Pone.0011885  0.778
2010 Dunn CD, Sulis ML, Ferrando AA, Greenwald I. A conserved tetraspanin subfamily promotes Notch signaling in Caenorhabditis elegans and in human cells. Proceedings of the National Academy of Sciences of the United States of America. 107: 5907-12. PMID 20220101 DOI: 10.1073/Pnas.1001647107  0.777
2008 Jarriault S, Schwab Y, Greenwald I. A Caenorhabditis elegans model for epithelial-neuronal transdifferentiation. Proceedings of the National Academy of Sciences of the United States of America. 105: 3790-5. PMID 18308937 DOI: 10.1073/Pnas.0712159105  0.741
2007 Myers TR, Greenwald I. Wnt signal from multiple tissues and lin-3/EGF signal from the gonad maintain vulval precursor cell competence in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 104: 20368-73. PMID 18077322 DOI: 10.1073/Pnas.0709989104  0.796
2007 de Souza N, Vallier LG, Fares H, Greenwald I. SEL-2, the C. elegans neurobeachin/LRBA homolog, is a negative regulator of lin-12/Notch activity and affects endosomal traffic in polarized epithelial cells. Development (Cambridge, England). 134: 691-702. PMID 17215302 DOI: 10.1242/Dev.02767  0.47
2006 Katic I, Greenwald I. EMB-4: a predicted ATPase that facilitates lin-12 activity in Caenorhabditis elegans. Genetics. 174: 1907-15. PMID 17030954 DOI: 10.1534/Genetics.106.063453  0.811
2006 Cui M, Chen J, Myers TR, Hwang BJ, Sternberg PW, Greenwald I, Han M. SynMuv genes redundantly inhibit lin-3/EGF expression to prevent inappropriate vulval induction in C. elegans. Developmental Cell. 10: 667-72. PMID 16678779 DOI: 10.1016/J.Devcel.2006.04.001  0.822
2005 Greenwald I. LIN-12/Notch signaling in C. elegans. Wormbook : the Online Review of C. Elegans Biology. 1-16. PMID 18050403 DOI: 10.1895/Wormbook.1.10.1  0.512
2005 Yoo AS, Greenwald I. LIN-12/Notch activation leads to microRNA-mediated down-regulation of Vav in C. elegans. Science (New York, N.Y.). 310: 1330-3. PMID 16239437 DOI: 10.1126/Science.1119481  0.683
2005 Shaye DD, Greenwald I. LIN-12/Notch trafficking and regulation of DSL ligand activity during vulval induction in Caenorhabditis elegans. Development (Cambridge, England). 132: 5081-92. PMID 16236769 DOI: 10.1242/Dev.02076  0.821
2005 Jarriault S, Greenwald I. Evidence for functional redundancy between C. elegans ADAM proteins SUP-17/Kuzbanian and ADM-4/TACE. Developmental Biology. 287: 1-10. PMID 16197940 DOI: 10.1016/J.Ydbio.2005.08.014  0.729
2005 Katic I, Vallier LG, Greenwald I. New positive regulators of lin-12 activity in Caenorhabditis elegans include the BRE-5/Brainiac glycosphingolipid biosynthesis enzyme. Genetics. 171: 1605-15. PMID 16157663 DOI: 10.1534/Genetics.105.048041  0.822
2005 Patton A, Knuth S, Schaheen B, Dang H, Greenwald I, Fares H. Endocytosis function of a ligand-gated ion channel homolog in Caenorhabditis elegans. Current Biology : Cb. 15: 1045-50. PMID 15936276 DOI: 10.1016/J.Cub.2005.04.057  0.339
2005 Myers TR, Greenwald I. lin-35 Rb acts in the major hypodermis to oppose ras-mediated vulval induction in C. elegans. Developmental Cell. 8: 117-23. PMID 15621535 DOI: 10.1016/J.Devcel.2004.11.015  0.806
2005 Greenwald I. Introduction to signal transduction Wormbook. DOI: 10.1895/Wormbook.1.20.1  0.39
2004 Karp X, Greenwald I. Multiple roles for the E/Daughterless ortholog HLH-2 during C. elegans gonadogenesis. Developmental Biology. 272: 460-9. PMID 15282161 DOI: 10.1016/J.Ydbio.2004.05.015  0.785
2004 Chen J, Li X, Greenwald I. sel-7, a positive regulator of lin-12 activity, encodes a novel nuclear protein in Caenorhabditis elegans. Genetics. 166: 151-60. PMID 15020414 DOI: 10.1534/Genetics.166.1.151  0.629
2004 Chen N, Greenwald I. The lateral signal for LIN-12/Notch in C. elegans vulval development comprises redundant secreted and transmembrane DSL proteins. Developmental Cell. 6: 183-92. PMID 14960273 DOI: 10.1016/S1534-5807(04)00021-8  0.602
2004 Yu H, Yoo AS, Greenwald I. Cluster Analyzer for Transcription Sites (CATS): a C++-based program for identifying clustered transcription factor binding sites. Bioinformatics (Oxford, England). 20: 1198-200. PMID 14764556 DOI: 10.1093/Bioinformatics/Bth057  0.619
2004 Yoo AS, Bais C, Greenwald I. Crosstalk between the EGFR and LIN-12/Notch pathways in C. elegans vulval development. Science (New York, N.Y.). 303: 663-6. PMID 14752159 DOI: 10.1126/Science.1091639  0.732
2003 Karp X, Greenwald I. Post-transcriptional regulation of the E/Daughterless ortholog HLH-2, negative feedback, and birth order bias during the AC/VU decision in C. elegans. Genes & Development. 17: 3100-11. PMID 14701877 DOI: 10.1101/Gad.1160803  0.777
2003 Jarriault S, Greenwald I. Induction and Lateral Specification Mediated by LIN-12/Notch Proteins Handbook of Cell Signaling. 2: 809-812. DOI: 10.1016/B978-012124546-7/50617-3  0.703
2002 Shaye DD, Greenwald I. Endocytosis-mediated downregulation of LIN-12/Notch upon Ras activation in Caenorhabditis elegans. Nature. 420: 686-90. PMID 12478297 DOI: 10.1038/Nature01234  0.815
2002 Jarriault S, Greenwald I. Suppressors of the egg-laying defective phenotype of sel-12 presenilin mutants implicate the CoREST corepressor complex in LIN-12/Notch signaling in C. elegans. Genes & Development. 16: 2713-28. PMID 12381669 DOI: 10.1101/Gad.1022402  0.804
2001 Fares H, Greenwald I. Regulation of endocytosis by CUP-5, the Caenorhabditis elegans mucolipin-1 homolog. Nature Genetics. 28: 64-8. PMID 11326278 DOI: 10.1038/Ng0501-64  0.415
2001 Struhl G, Greenwald I. Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. 98: 229-34. PMID 11134525 DOI: 10.1073/Pnas.98.1.229  0.477
2001 Wen C, Levitan D, Li X, Greenwald I. spr-2, a suppressor of the egg-laying defect caused by loss of sel-12 presenilin in Caenorhabditis elegans, is a member of the SET protein subfamily. Proceedings of the National Academy of Sciences of the United States of America. 97: 14524-9. PMID 11114162 DOI: 10.1073/Pnas.011446498  0.465
2001 Struhl G, Greenwald I. Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila Proceedings of the National Academy of Sciences. 98: 229-234. DOI: 10.1073/PNAS.98.1.229  0.332
2000 Doyle TG, Wen C, Greenwald I. SEL-8, a nuclear protein required for LIN-12 and GLP-1 signaling in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 97: 7877-81. PMID 10884418 DOI: 10.1073/Pnas.97.14.7877  0.778
1999 Wen C, Greenwald I. p24 proteins and quality control of LIN-12 and GLP-1 trafficking in Caenorhabditis elegans. The Journal of Cell Biology. 145: 1165-75. PMID 10366590 DOI: 10.1083/Jcb.145.6.1165  0.424
1999 Struhl G, Greenwald I. Presenilin is required for activity and nuclear access of Notch in Drosophila. Nature. 398: 522-5. PMID 10206646 DOI: 10.1038/19091  0.432
1998 Wu G, Hubbard EJA, Kitajewski JK, Greenwald I. Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin Proceedings of the National Academy of Sciences of the United States of America. 95: 15787-15791. PMID 9861048 DOI: 10.1073/Pnas.95.26.15787  0.392
1998 Greenwald I. LIN-12/Notch signaling: lessons from worms and flies. Genes & Development. 12: 1751-62. PMID 9637676 DOI: 10.1101/Gad.12.12.1751  0.477
1998 Li X, Greenwald I. Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins. Proceedings of the National Academy of Sciences of the United States of America. 95: 7109-14. PMID 9618547 DOI: 10.1073/Pnas.95.12.7109  0.309
1997 Hubbard EJA, Wu G, Kitajewski J, Greenwald I. sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins Genes and Development. 11: 3182-3193. PMID 9389650 DOI: 10.1101/Gad.11.23.3182  0.506
1997 Li X, Greenwald I. HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling. Proceedings of the National Academy of Sciences of the United States of America. 94: 12204-9. PMID 9342387 DOI: 10.1073/Pnas.94.22.12204  0.456
1997 Li X, Greenwald I. Membrane topology of the C. elegans SEL-12 presenilin. Neuron. 17: 1015-21. PMID 8938132 DOI: 10.1016/S0896-6273(00)80231-7  0.324
1996 Levitan D, Doyle TG, Brousseau D, Lee MK, Thinakaran G, Slunt HH, Sisodia SS, Greenwald I. Assessment of normal and mutant human presenilin function in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 93: 14940-4. PMID 8962160 DOI: 10.1073/Pnas.93.25.14940  0.727
1996 Hubbard EJ, Dong Q, Greenwald I. Evidence for physical and functional association between EMB-5 and LIN-12 in Caenorhabditis elegans. Science (New York, N.Y.). 273: 112-5. PMID 8658178 DOI: 10.1126/Science.273.5271.112  0.49
1995 Beitel GJ, Tuck S, Greenwald I, Horvitz HR. The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway. Genes & Development. 9: 3149-62. PMID 8543158 DOI: 10.1101/Gad.9.24.3149  0.804
1995 Wilkinson HA, Fitzgerald K, Greenwald I. Reciprocal changes in expression of the receptor lin-12 and its ligand lag-2 prior to commitment in a C. elegans cell fate decision. Cell. 79: 1187-98. PMID 8001154 DOI: 10.1016/0092-8674(94)90010-8  0.405
1995 Tuck S, Greenwald I. lin-25, a gene required for vulval induction in Caenorhabditis elegans. Genes & Development. 9: 341-57. PMID 7867931 DOI: 10.1101/Gad.9.3.341  0.534
1995 Levitan D, Greenwald I. Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature. 377: 351-4. PMID 7566091 DOI: 10.1038/377351A0  0.463
1994 Greenwald I. Structure/function studies of lin-12/Notch proteins. Current Opinion in Genetics & Development. 4: 556-62. PMID 7950324 DOI: 10.1016/0959-437X(94)90072-B  0.486
1993 Yochem J, Greenwald I. A gene for a low density lipoprotein receptor-related protein in the nematode Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 90: 4572-6. PMID 8506301 DOI: 10.1073/Pnas.90.10.4572  0.362
1993 Seydoux G, Savage C, Greenwald I. Isolation and characterization of mutations causing abnormal eversion of the vulva in Caenorhabditis elegans. Developmental Biology. 157: 423-36. PMID 8500652 DOI: 10.1006/Dbio.1993.1146  0.41
1993 Morgan WR, Greenwald I. Two novel transmembrane protein tyrosine kinases expressed during Caenorhabditis elegans hypodermal development. Molecular and Cellular Biology. 13: 7133-43. PMID 8413302 DOI: 10.1128/MCB.13.11.7133  0.349
1993 Struhl G, Fitzgerald K, Greenwald I. Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo. Cell. 74: 331-45. PMID 8343960 DOI: 10.1016/0092-8674(93)90424-O  0.483
1992 Greenwald I, Rubin GM. Making a difference: the role of cell-cell interactions in establishing separate identities for equivalent cells. Cell. 68: 271-81. PMID 1365402 DOI: 10.1016/0092-8674(92)90470-W  0.446
1991 Greenwald I, Broach JR. Cell fates in C. elegans: in medias ras. Cell. 63: 1113-6. PMID 2261634 DOI: 10.1016/0092-8674(90)90403-2  0.337
1990 Seydoux G, Schedl T, Greenwald I. Cell-cell interactions prevent a potential inductive interaction between soma and germline in C. elegans. Cell. 61: 939-51. PMID 2350786 DOI: 10.1016/0092-8674(90)90060-R  0.43
1990 Greenwald I. Genetic and molecular analysis of EGF- related genes in Caenorhabditis elegans. Molecular Reproduction and Development. 27: 73-79. PMID 2271190 DOI: 10.1002/Mrd.1080270114  0.306
1990 Greenwald I, Seydoux G. Analysis of gain-of-function mutations of the lin-12 gene of Caenorhabditis elegans. Nature. 346: 197-9. PMID 2164160 DOI: 10.1038/346197A0  0.467
1989 Yochem J, Greenwald I. glp-1 and lin-12, genes implicated in distinct cell-cell interactions in C. elegans, encode similar transmembrane proteins. Cell. 58: 553-63. PMID 2758466 DOI: 10.1016/0092-8674(89)90436-4  0.406
1989 Seydoux G, Greenwald I. Cell autonomy of lin-12 function in a cell fate decision in C. elegans. Cell. 57: 1237-45. PMID 2736627 DOI: 10.1016/0092-8674(89)90060-3  0.45
1989 Greenwald I. Cell-cell interactions that specify certain cell fates in C. elegans development. Trends in Genetics : Tig. 5: 237-41. PMID 2686111 DOI: 10.1016/0168-9525(89)90094-2  0.423
1988 Yochem J, Weston K, Greenwald I. The Caenorhabditis elegans lin-12 gene encodes a transmembrane protein with overall similarity to Drosophila Notch. Nature. 335: 547-50. PMID 3419531 DOI: 10.1038/335547A0  0.432
1987 Greenwald I. The lin-12 locus of Caenorhabditis elegans. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 6: 70-3. PMID 3551950 DOI: 10.1002/Bies.950060207  0.414
1983 Greenwald IS, Sternberg PW, Horvitz HR. The lin-12 locus specifies cell fates in Caenorhabditis elegans. Cell. 34: 435-44. PMID 6616618 DOI: 10.1016/0092-8674(83)90377-X  0.684
1983 Horvitz HR, Sternberg PW, Greenwald IS, Fixsen W, Ellis HM. Mutations that affect neural cell lineages and cell fates during the development of the nematode Caenorhabditis elegans. Cold Spring Harbor Symposia On Quantitative Biology. 48: 453-63. PMID 6586368 DOI: 10.1101/Sqb.1983.048.01.050  0.69
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