Kristopher T. Kahle, Ph.D. - Publications

Affiliations: 
2007 Yale University, New Haven, CT 
Area:
Physiology Biology, Genetics
Website:
https://medicine.yale.edu/intranet/facultybydept/kristopher_kahle.profile

135 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Allocco AA, Jin SC, Duy PQ, Furey CG, Zeng X, Dong W, Nelson-Williams C, Karimy JK, DeSpenza T, Hao LT, Reeves B, Haider S, Gunel M, Lifton RP, Kahle KT. Recessive Inheritance of Congenital Hydrocephalus With Other Structural Brain Abnormalities Caused by Compound Heterozygous Mutations in . Frontiers in Cellular Neuroscience. 13: 425. PMID 31616254 DOI: 10.3389/fncel.2019.00425  1
2019 Watanabe M, Zhang J, Mansuri MS, Duan J, Karimy JK, Delpire E, Alper SL, Lifton RP, Fukuda A, Kahle KT. Developmentally regulated KCC2 phosphorylation is essential for dynamic GABA-mediated inhibition and survival. Science Signaling. 12. PMID 31615901 DOI: 10.1126/scisignal.aaw9315  1
2019 Pisella LI, Gaiarsa JL, Diabira D, Zhang J, Khalilov I, Duan J, Kahle KT, Medina I. Impaired regulation of KCC2 phosphorylation leads to neuronal network dysfunction and neurodevelopmental pathology. Science Signaling. 12. PMID 31615899 DOI: 10.1126/scisignal.aay0300  1
2019 Lanni JS, Peal D, Ekstrom L, Chen H, Stanclift C, Bowen ME, Mercado A, Gamba G, Kahle KT, Harris MP. Integrated K+ channel and K+Cl- cotransporter function are required for the coordination of size and proportion during development. Developmental Biology. PMID 31472116 DOI: 10.1016/j.ydbio.2019.08.016  1
2019 Jin SC, Furey CG, Zeng X, Allocco A, Nelson-Williams C, Dong W, Karimy JK, Wang K, Ma S, Delpire E, Kahle KT. SLC12A ion transporter mutations in sporadic and familial human congenital hydrocephalus. Molecular Genetics & Genomic Medicine. e892. PMID 31393094 DOI: 10.1002/mgg3.892  1
2019 Huang H, Song S, Banerjee S, Jiang T, Zhang J, Kahle KT, Sun D, Zhang Z. The WNK-SPAK/OSR1 Kinases and the Cation-Chloride Cotransporters as Therapeutic Targets for Neurological Diseases. Aging and Disease. 10: 626-636. PMID 31165006 DOI: 10.14336/AD.2018.0928  1
2019 Zeng X, Hunt A, Jin SC, Duran D, Gaillard J, Kahle KT. EphrinB2-EphB4-RASA1 Signaling in Human Cerebrovascular Development and Disease. Trends in Molecular Medicine. PMID 30819650 DOI: 10.1016/j.molmed.2019.01.009  1
2018 Duran D, Zeng X, Jin SC, Choi J, Nelson-Williams C, Yatsula B, Gaillard J, Furey CG, Lu Q, Timberlake AT, Dong W, Sorscher MA, Loring E, Klein J, Allocco A, ... ... Kahle KT, et al. Mutations in Chromatin Modifier and Ephrin Signaling Genes in Vein of Galen Malformation. Neuron. PMID 30578106 DOI: 10.1016/j.neuron.2018.11.041  1
2018 Furey CG, Zeng X, Dong W, Jin SC, Choi J, Timberlake AT, Dunbar AM, Allocco AA, Günel M, Lifton RP, Kahle KT. Human genetics and molecular mechanisms of congenital hydrocephalus. World Neurosurgery. PMID 30205212 DOI: 10.1016/j.wneu.2018.09.018  1
2018 Furey CG, Choi J, Jin SC, Zeng X, Timberlake AT, Nelson-Williams C, Mansuri MS, Lu Q, Duran D, Panchagnula S, Allocco A, Karimy JK, Khanna A, Gaillard JR, DeSpenza T, ... ... Kahle KT, et al. De Novo Mutation in Genes Regulating Neural Stem Cell Fate in Human Congenital Hydrocephalus. Neuron. PMID 29983323 DOI: 10.1016/j.neuron.2018.06.019  1
2018 Fomchenko EI, Duran D, Jin SC, Dong W, Erson-Omay EZ, Antwi P, Allocco A, Gaillard JR, Huttner A, Gunel M, DiLuna ML, Kahle KT. Novel association of germline de novo MYH9 mutation with congenital hemangioma. Cold Spring Harbor Molecular Case Studies. PMID 29903892 DOI: 10.1101/mcs.a002998  1
2018 Furey C, Antwi P, Duran D, Timberlake AT, Nelson-Williams C, Matouk CC, DiLuna ML, Günel M, Kahle KT. 9p24 triplication and 15q13 deletion in syndromic hydrocephalus with diffuse villous hyperplasia of the choroid plexus. Cold Spring Harbor Molecular Case Studies. PMID 29895553 DOI: 10.1101/mcs.a003145  1
2018 Montejo JD, Camara-Quintana JQ, Duran D, Rockefeller JM, Conine SB, Blaise AM, Kahle KT, DiLuna ML. Tubular approach to minimally invasive microdiscectomy for pediatric lumbar disc herniation. Journal of Neurosurgery. Pediatrics. 1-7. PMID 29473813 DOI: 10.3171/2017.11.PEDS17293  1
2018 Duran D, Karschnia P, Gaillard JR, Karimy JK, Youngblood MW, DiLuna ML, Matouk CC, Aagaard-Kienitz B, Smith ER, Orbach DB, Rodesch G, Berenstein A, Gunel M, Kahle KT. Human genetics and molecular mechanisms of vein of Galen malformation. Journal of Neurosurgery. Pediatrics. 1-8. PMID 29350590 DOI: 10.3171/2017.9.PEDS17365  1
2017 Heubl M, Zhang J, Pressey JC, Al Awabdh S, Renner M, Gomez-Castro F, Moutkine I, Eugène E, Russeau M, Kahle KT, Poncer JC, Lévi S. GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl--sensitive WNK1 kinase. Nature Communications. 8: 1776. PMID 29176664 DOI: 10.1038/s41467-017-01749-0  1
2017 Furey CG, Timberlake AT, Nelson-Williams C, Duran D, Li P, Jackson EM, Kahle KT. Xp22.2 Chromosomal Duplication in Familial Intracranial Arachnoid Cyst. Jama Neurology. PMID 29052703 DOI: 10.1001/jamaneurol.2017.3399  1
2017 Timberlake AT, Furey CG, Choi J, Nelson-Williams C, Loring E, Galm A, Kahle KT, Steinbacher DM, Larysz D, Persing JA, Lifton RP. De novo mutations in inhibitors of Wnt, BMP, and Ras/ERK signaling pathways in non-syndromic midline craniosynostosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 28808027 DOI: 10.1073/pnas.1709255114  1
2017 Duran D, Messina RD, Beslow LA, Montejo JD, Karimy JK, Gavankar Furey C, Sheridan AD, Sze G, Yarman Y, DiLuna ML, Kahle KT. Malignant Cerebellar Edema Subsequent to Accidental Prescription Opioid Intoxication in Children. Frontiers in Neurology. 8: 362. PMID 28790973 DOI: 10.3389/fneur.2017.00362  1
2017 Karimy JK, Zhang J, Kurland DB, Theriault BC, Duran D, Stokum JA, Furey CG, Zhou X, Mansuri MS, Montejo J, Vera A, DiLuna ML, Delpire E, Alper SL, Gunel M, ... ... Kahle KT, et al. Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus. Nature Medicine. PMID 28692063 DOI: 10.1038/nm.4361  1
2017 Zhang J, Karimy JK, Delpire E, Kahle KT. Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport. Expert Opinion On Therapeutic Targets. PMID 28679296 DOI: 10.1080/14728222.2017.1351949  1
2017 Shekarabi M, Zhang J, Khanna AR, Ellison DH, Delpire E, Kahle KT. WNK Kinase Signaling in Ion Homeostasis and Human Disease. Cell Metabolism. 25: 285-299. PMID 28178566 DOI: 10.1016/j.cmet.2017.01.007  1
2016 Davoli T, Mengwasser KE, Duan J, Chen T, Christensen C, Wooten EC, Anselmo AN, Li MZ, Wong KK, Kahle KT, Elledge SJ. Functional genomics reveals that tumors with activating phosphoinositide 3-kinase mutations are dependent on accelerated protein turnover. Genes & Development. 30: 2684-2695. PMID 28087713 DOI: 10.1101/gad.290122.116  1
2016 Duran D, Jin SC, DeSpenza T, Nelson-Williams C, Cogal AG, Abrash EW, Harris PC, Lieske JC, Shimshak SJ, Mane S, Bilguvar K, DiLuna ML, Günel M, Lifton RP, Kahle KT. Digenic mutations of human OCRL paralogs in Dent's disease type 2 associated with Chiari I malformation. Human Genome Variation. 3: 16042. PMID 28018608 DOI: 10.1038/hgv.2016.42  1
2016 Zhang J, Deng X, Kahle KT. Leveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition. Science Signaling. 9: pe3. PMID 27811182 DOI: 10.1126/scisignal.aaj2227  1
2016 Karimy JK, Duran D, Hu JK, Gavankar C, Gaillard JR, Bayri Y, Rice H, DiLuna ML, Gerzanich V, Marc Simard J, Kahle KT. Cerebrospinal fluid hypersecretion in pediatric hydrocephalus. Neurosurgical Focus. 41: E10. PMID 27798982 DOI: 10.3171/2016.8.FOCUS16278  1
2016 Bhuiyan MI, Song S, Yuan H, Begum G, Kofler J, Kahle KT, Yang SS, Lin SH, Alper SL, Subramanya AR, Sun D. WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 27798271 DOI: 10.1177/0271678X16675368  1
2016 Zhang J, Gao G, Begum G, Wang J, Khanna AR, Shmukler BE, Daubner GM, de Los Heros P, Davies P, Varghese J, Bhuiyan MI, Duan J, Zhang J, Duran D, Alper SL, ... ... Kahle KT, et al. Functional kinomics establishes a critical node of volume-sensitive cation-Cl(-) cotransporter regulation in the mammalian brain. Scientific Reports. 6: 35986. PMID 27782176 DOI: 10.1038/srep35986  1
2016 Kahle KT, Flores B, Bharucha-Goebel D, Zhang J, Donkervoort S, Hegde M, Hussain G, Duran D, Liang B, Sun D, Bönnemann CG, Delpire E. Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporter. Science Signaling. 9: ra77. PMID 27485015 DOI: 10.1126/scisignal.aae0546  1
2016 Kahle KT, Khanna AR, Duan J, Staley KJ, Delpire E, Poduri A. The KCC2 Cotransporter and Human Epilepsy: Getting Excited About Inhibition. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. PMID 27130838 DOI: 10.1177/1073858416645087  1
2016 Kahle KT, Schmouth JF, Lavastre V, Latremoliere A, Zhang J, Andrews N, Omura T, Laganière J, Rochefort D, Hince P, Castonguay G, Gaudet R, Mapplebeck JC, Sotocinal SG, Duan J, et al. Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition. Science Signaling. 9: ra32. PMID 27025876 DOI: 10.1126/scisignal.aad0163  1
2016 Merner ND, Mercado A, Khanna AR, Hodgkinson A, Bruat V, Awadalla P, Gamba G, Rouleau GA, Kahle KT. Gain-of-function missense variant in SLC12A2, encoding the bumetanide-sensitive NKCC1 cotransporter, identified in human schizophrenia. Journal of Psychiatric Research. 77: 22-26. PMID 26955005 DOI: 10.1016/j.jpsychires.2016.02.016  1
2016 Leasure A, Kimberly WT, Sansing LH, Kahle KT, Kronenberg G, Kunte H, Simard JM, Sheth KN. Treatment of Edema Associated With Intracerebral Hemorrhage. Current Treatment Options in Neurology. 18: 9. PMID 26874842 DOI: 10.1007/s11940-015-0392-z  1
2016 Zhao H, Nepomuceno R, Gao X, Foley LM, Wang S, Begum G, Zhu W, Pigott VM, Falgoust LM, Kahle KT, Yang SS, Lin SH, Alper SL, Kevin Hitchens T, Hu S, et al. Deletion of the WNK3-SPAK kinase complex in mice improves radiographic and clinical outcomes in malignant cerebral edema after ischemic stroke. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 26861815 DOI: 10.1177/0271678X16631561  1
2015 Merner ND, Chandler MR, Bourassa C, Liang B, Khanna AR, Dion P, Rouleau GA, Kahle KT. Regulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophrenia. Frontiers in Cellular Neuroscience. 9: 386. PMID 26528127 DOI: 10.3389/fncel.2015.00386  1
2015 Kahle KT, Delpire E. Kinase-KCC2 coupling: Cl- rheostasis, disease susceptibility, therapeutic target. Journal of Neurophysiology. jn.00865.2015. PMID 26510764 DOI: 10.1152/jn.00865.2015  1
2015 Kahle KT, Kulkarni AV, Limbrick DD, Warf BC. Hydrocephalus in children. Lancet (London, England). PMID 26256071 DOI: 10.1016/S0140-6736(15)60694-8  1
2015 Adragna NC, Ravilla NB, Lauf PK, Begum G, Khanna AR, Sun D, Kahle KT. Regulated phosphorylation of the K-Cl cotransporter KCC3 is a molecular switch of intracellular potassium content and cell volume homeostasis. Frontiers in Cellular Neuroscience. 9: 255. PMID 26217182 DOI: 10.3389/fncel.2015.00255  1
2015 Kahle KT, Khanna AR, Alper SL, Adragna NC, Lauf PK, Sun D, Delpire E. K-Cl cotransporters, cell volume homeostasis, and neurological disease. Trends in Molecular Medicine. 21: 513-23. PMID 26142773 DOI: 10.1016/j.molmed.2015.05.008  1
2015 Friedel P, Kahle KT, Zhang J, Hertz N, Pisella LI, Buhler E, Schaller F, Duan J, Khanna AR, Bishop PN, Shokat KM, Medina I. WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons. Science Signaling. 8: ra65. PMID 26126716 DOI: 10.1126/scisignal.aaa0354  1
2015 Begum G, Yuan H, Kahle KT, Li L, Wang S, Shi Y, Shmukler BE, Yang SS, Lin SH, Alper SL, Sun D. Inhibition of WNK3 Kinase Signaling Reduces Brain Damage and Accelerates Neurological Recovery After Stroke. Stroke; a Journal of Cerebral Circulation. 46: 1956-65. PMID 26069258 DOI: 10.1161/STROKEAHA.115.008939  1
2015 Khanna A, Simard JM, Kahle KT. Progesterone in traumatic brain injury. The New England Journal of Medicine. 372: 1765-6. PMID 25923560 DOI: 10.1056/NEJMc1503138#SA2  1
2015 Ang JW, Khanna A, Walcott BP, Kahle KT, Eskandar EN. Central nervous system lymphoma presenting as trigeminal neuralgia: A diagnostic challenge. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. 22: 1188-90. PMID 25865026 DOI: 10.1016/j.jocn.2015.01.018  1
2015 Karimy JK, Kahle KT, Kurland DB, Yu E, Gerzanich V, Simard JM. A novel method to study cerebrospinal fluid dynamics in rats. Journal of Neuroscience Methods. 241: 78-84. PMID 25554415 DOI: 10.1016/j.jneumeth.2014.12.015  1
2015 Campbell SL, Robel S, Cuddapah VA, Robert S, Buckingham SC, Kahle KT, Sontheimer H. GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy. Glia. 63: 23-36. PMID 25066727 DOI: 10.1002/glia.22730  1
2014 Alessi DR, Zhang J, Khanna A, Hochdörfer T, Shang Y, Kahle KT. The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters. Science Signaling. 7: re3. PMID 25028718 DOI: 10.1126/scisignal.2005365  1
2014 Kahle KT, Merner ND, Friedel P, Silayeva L, Liang B, Khanna A, Shang Y, Lachance-Touchette P, Bourassa C, Levert A, Dion PA, Walcott B, Spiegelman D, Dionne-Laporte A, Hodgkinson A, et al. Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy. Embo Reports. 15: 766-74. PMID 24928908 DOI: 10.15252/embr.201438840  1
2014 Puskarjov M, Kahle KT, Ruusuvuori E, Kaila K. Pharmacotherapeutic targeting of cation-chloride cotransporters in neonatal seizures. Epilepsia. 55: 806-18. PMID 24802699 DOI: 10.1111/epi.12620  1
2014 Kahle KT, Khanna A, Clapham DE, Woolf CJ. Therapeutic restoration of spinal inhibition via druggable enhancement of potassium-chloride cotransporter KCC2-mediated chloride extrusion in peripheral neuropathic pain. Jama Neurology. 71: 640-5. PMID 24615367 DOI: 10.1001/jamaneurol.2014.21  1
2014 Zhu W, Begum G, Pointer K, Clark PA, Yang SS, Lin SH, Kahle KT, Kuo JS, Sun D. WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration. Molecular Cancer. 13: 31. PMID 24555568 DOI: 10.1186/1476-4598-13-31  1
2014 Sun D, Kahle KT. Dysregulation of diverse ion transport pathways controlling cell volume homoestasis contribute to neuroglial cell injury following ischemic stroke. Translational Stroke Research. 5: 1-2. PMID 24464825 DOI: 10.1007/s12975-014-0324-3  0.36
2014 de Los Heros P, Alessi DR, Gourlay R, Campbell DG, Deak M, Macartney TJ, Kahle KT, Zhang J. The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters. The Biochemical Journal. 458: 559-73. PMID 24393035 DOI: 10.1042/BJ20131478  1
2014 Khanna A, Walcott BP, Kahle KT, Simard JM. Effect of glibenclamide on the prevention of secondary brain injury following ischemic stroke in humans. Neurosurgical Focus. 36: E11. PMID 24380477 DOI: 10.3171/2013.10.FOCUS13404  1
2014 Khanna A, Kahle KT, Walcott BP, Gerzanich V, Simard JM. Disruption of ion homeostasis in the neurogliovascular unit underlies the pathogenesis of ischemic cerebral edema. Translational Stroke Research. 5: 3-16. PMID 24323726 DOI: 10.1007/s12975-013-0307-9  1
2014 Lee HK, Ahmed MM, King KC, Miranpuri GS, Kahle KT, Resnick DK, Sun D. Persistent phosphorylation of NKCC1 and WNK1 in the epicenter of the spinal cord following contusion injury. The Spine Journal : Official Journal of the North American Spine Society. 14: 777-81. PMID 24239489 DOI: 10.1016/j.spinee.2013.06.100  1
2014 Walcott BP, Neal JB, Sheth SA, Kahle KT, Eskandar EN, Coumans JV, Nahed BV. The incidence of complications in elective cranial neurosurgery associated with dural closure material. Journal of Neurosurgery. 120: 278-84. PMID 24032702 DOI: 10.3171/2013.8.JNS13703  1
2014 Walcott BP, Miller JC, Kwon CS, Sheth SA, Hiller M, Cronin CA, Schwamm LH, Simard JM, Kahle KT, Kimberly WT, Sheth KN. Outcomes in severe middle cerebral artery ischemic stroke. Neurocritical Care. 21: 20-6. PMID 23839704 DOI: 10.1007/s12028-013-9838-x  1
2013 Kahle KT, Deeb TZ, Puskarjov M, Silayeva L, Liang B, Kaila K, Moss SJ. Modulation of neuronal activity by phosphorylation of the K-Cl cotransporter KCC2. Trends in Neurosciences. 36: 726-37. PMID 24139641 DOI: 10.1016/j.tins.2013.08.006  1
2013 Khanna A, Venteicher AS, Walcott BP, Kahle KT, Mordes DA, William CM, Ghogawala Z, Ogilvy CS. Glioblastoma mimicking an arteriovenous malformation. Frontiers in Neurology. 4: 144. PMID 24137154 DOI: 10.3389/fneur.2013.00144  1
2013 Codd PJ, Venteicher AS, Agarwalla PK, Kahle KT, Jho DH. Endoscopic burr hole evacuation of an acute subdural hematoma. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. 20: 1751-3. PMID 23962631 DOI: 10.1016/j.jocn.2013.02.019  1
2013 Khanna A, Walcott BP, Kahle KT. Limitations of Current GABA Agonists in Neonatal Seizures: Toward GABA Modulation Via the Targeting of Neuronal Cl(-) Transport. Frontiers in Neurology. 4: 78. PMID 23805124 DOI: 10.3389/fneur.2013.00078  1
2013 Cleary RT, Sun H, Huynh T, Manning SM, Li Y, Rotenberg A, Talos DM, Kahle KT, Jackson M, Rakhade SN, Berry G, Berry G, Jensen FE. Bumetanide enhances phenobarbital efficacy in a rat model of hypoxic neonatal seizures. Plos One. 8: e57148. PMID 23536761 DOI: 10.1371/journal.pone.0057148  1
2013 Arroyo JP, Kahle KT, Gamba G. The SLC12 family of electroneutral cation-coupled chloride cotransporters. Molecular Aspects of Medicine. 34: 288-98. PMID 23506871 DOI: 10.1016/j.mam.2012.05.002  1
2013 Ryu JH, Walcott BP, Kahle KT, Sheth SA, Peterson RT, Nahed BV, Coumans JV, Simard JM. Induced and sustained hypernatremia for the prevention and treatment of cerebral edema following brain injury. Neurocritical Care. 19: 222-31. PMID 23468135 DOI: 10.1007/s12028-013-9824-3  1
2013 Kahle KT, Walcott BP, Simard JM. Continuous hyperosmolar therapy for traumatic brain injury-associated cerebral edema: as good as it gets, or an iatrogenic secondary insult? Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. 20: 30-1. PMID 23200533 DOI: 10.1016/j.jocn.2012.10.004  1
2013 Walcott BP, Kahle KT, Simard JM. The DECRA trial and decompressive craniectomy in diffuse traumatic brain injury: is decompression really ineffective? World Neurosurgery. 79: 80-1. PMID 23159659 DOI: 10.1016/j.wneu.2012.11.014  1
2012 Algharabil J, Kintner DB, Wang Q, Begum G, Clark PA, Yang SS, Lin SH, Kahle KT, Kuo JS, Sun D. Inhibition of Na(+)-K(+)-2Cl(-) cotransporter isoform 1 accelerates temozolomide-mediated apoptosis in glioblastoma cancer cells. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 30: 33-48. PMID 22759954 DOI: 10.1159/000339047  1
2012 Walcott BP, Edlow BL, Xia Z, Kahle KT, Nahed BV, Schmahmann JD. Steroid responsive A3243G mutation MELAS: clinical and radiographic evidence for regional hyperperfusion leading to neuronal loss. The Neurologist. 18: 159-70. PMID 22549360 DOI: 10.1097/NRL.0b013e318247bcd8  1
2012 Ben-Ari Y, Khalilov I, Kahle KT, Cherubini E. The GABA excitatory/inhibitory shift in brain maturation and neurological disorders. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 18: 467-86. PMID 22547529 DOI: 10.1177/1073858412438697  1
2012 Walcott BP, Nahed BV, Mohyeldin A, Coumans JV, Kahle KT, Ferreira MJ. Chordoma: current concepts, management, and future directions. The Lancet. Oncology. 13: e69-76. PMID 22300861 DOI: 10.1016/S1470-2045(11)70337-0  1
2012 Walcott BP, Kahle KT, Butler WE. Endoscopic treatment of hydrocephalus. Archives of Neurology. 69: 664. PMID 22271236 DOI: 10.1001/archneurol.2011.1766  1
2012 Walcott BP, Nahed BV, Kahle KT, Duhaime AC, Sharma N, Eskandar EN. Deep brain stimulation for medically refractory life-threatening status dystonicus in children. Journal of Neurosurgery. Pediatrics. 9: 99-102. PMID 22208329 DOI: 10.3171/2011.10.PEDS11360  1
2012 Walcott BP, Kahle KT, Nahed BV, Coumans JV, Asaad WF. The use of intra-operative blood gas analysis in the investigation of suspected iatrogenic vascular injury. European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. 21: S492-4. PMID 22167452 DOI: 10.1007/s00586-011-2116-8  1
2012 Kessler JD, Kahle KT, Sun T, Meerbrey KL, Schlabach MR, Schmitt EM, Skinner SO, Xu Q, Li MZ, Hartman ZC, Rao M, Yu P, Dominguez-Vidana R, Liang AC, Solimini NL, et al. A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. Science (New York, N.Y.). 335: 348-53. PMID 22157079 DOI: 10.1126/science.1212728  1
2012 Walcott BP, Kahle KT, Simard JM. Novel treatment targets for cerebral edema. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 9: 65-72. PMID 22125096 DOI: 10.1007/s13311-011-0087-4  1
2012 Walcott BP, Nahed BV, Sarpong Y, Kahle KT, Sekhar LN, Ferreira MJ. Incidence of cerebrospinal fluid leak following petrosectomy and analysis of avoidance techniques. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. 19: 92-4. PMID 22104349 DOI: 10.1016/j.jocn.2011.08.001  1
2012 Stapleton CJ, Walcott BP, Kahle KT, Codd PJ, Nahed BV, Chen L, Robison NJ, Delalle I, Goumnerova LC, Jackson EM. Diffuse central neurocytoma with craniospinal dissemination. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. 19: 163-6. PMID 22088950 DOI: 10.1016/j.jocn.2011.07.016  1
2012 Walcott BP, Nahed BV, Kahle KT, Sekhar LN, Ferreira MJ. Cerebrovascular bypass and aneurysm trapping for the treatment of an A2-segment anterior cerebral artery pseudoaneurysm and herniation through a skull base defect following trauma. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. 19: 149-51. PMID 22051032 DOI: 10.1016/j.jocn.2011.05.017  1
2012 Barnard ZR, Walcott BP, Kahle KT, Nahed BV, Coumans JV. Hyponatremia associated with Ipilimumab-induced hypophysitis. Medical Oncology (Northwood, London, England). 29: 374-7. PMID 21264545 DOI: 10.1007/s12032-010-9794-7  1
2011 Bashinskaya B, Nahed BV, Redjal N, Kahle KT, Walcott BP. Trends in Peptic Ulcer Disease and the Identification of Helicobacter Pylori as a Causative Organism: Population-based Estimates from the US Nationwide Inpatient Sample. Journal of Global Infectious Diseases. 3: 366-70. PMID 22224001 DOI: 10.4103/0974-777X.91061  1
2011 Walcott BP, Kuklina EV, Nahed BV, George MG, Kahle KT, Simard JM, Asaad WF, Coumans JV. Craniectomy for malignant cerebral infarction: prevalence and outcomes in US hospitals. Plos One. 6: e29193. PMID 22195021 DOI: 10.1371/journal.pone.0029193  1
2011 Kesari S, Advani SJ, Lawson JD, Kahle KT, Ng K, Carter B, Chen CC. DNA damage response and repair: insights into strategies for radiation sensitization of gliomas. Future Oncology (London, England). 7: 1335-46. PMID 22044206 DOI: 10.2217/fon.11.111  1
2011 Walcott BP, Coumans JV, Mian MK, Nahed BV, Kahle KT. Interfacility helicopter ambulance transport of neurosurgical patients: observations, utilization, and outcomes from a quaternary level care hospital. Plos One. 6: e26216. PMID 22022572 DOI: 10.1371/journal.pone.0026216  1
2011 Pisapia JM, Walcott BP, Nahed BV, Kahle KT, Ogilvy CS. Cerebral revascularization for the treatment of complex intracranial aneurysms of the posterior circulation: microsurgical anatomy, techniques and outcomes. Journal of Neurointerventional Surgery. 3: 249-54. PMID 21990836 DOI: 10.1136/jnis.2010.004176  1
2011 Walcott BP, Nahed BV, Redjal N, Stein TD, Kahle KT, Coumans JV. Pathological mechanism of lumbar disc herniation resulting in neurogenic muscle hypertrophy. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. 18: 1682-4. PMID 21985744 DOI: 10.1016/j.jocn.2011.03.033  1
2011 Walcott BP, Coumans JV, Kahle KT. Diagnostic pitfalls in spine surgery: masqueraders of surgical spine disease. Neurosurgical Focus. 31: E1. PMID 21961853 DOI: 10.3171/2011.7.FOCUS11114  1
2011 Coumans JV, Walcott BP, Butler WE, Nahed BV, Kahle KT. Volumetric analysis of syringomyelia following hindbrain decompression for Chiari malformation Type I: syringomyelia resolution follows exponential kinetics. Neurosurgical Focus. 31: E4. PMID 21882909 DOI: 10.3171/2011.6.FOCUS11106  1
2011 Schanker BD, Walcott BP, Nahed BV, Kahle KT, Li YM, Coumans JV. Familial Chiari malformation: case series. Neurosurgical Focus. 31: E1. PMID 21882906 DOI: 10.3171/2011.6.FOCUS11104  1
2011 Walcott BP, Kahle KT. Blast-related traumatic brain injury in U.S. military personnel. The New England Journal of Medicine. 365: 860. PMID 21879908 DOI: 10.1056/NEJMc1107891#SA2  1
2011 Maa EH, Kahle KT, Walcott BP, Spitz MC, Staley KJ. Diuretics and epilepsy: will the past and present meet? Epilepsia. 52: 1559-69. PMID 21838793 DOI: 10.1111/j.1528-1167.2011.03203.x  1
2011 Walcott BP, Cvetanovich GL, Barnard ZR, Nahed BV, Kahle KT, Curry WT. Surgical treatment and outcomes of metastatic breast cancer to the spine. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. 18: 1336-9. PMID 21782449 DOI: 10.1016/j.jocn.2011.02.020  1
2011 Aghi MK, Walcott BP, Nahed BV, Cvetanovich GL, Kahle KT, Redjal N, Coumans JV. Determinants of initial bone graft volume loss in posterolateral lumbar fusion. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. 18: 1193-6. PMID 21745744 DOI: 10.1016/j.jocn.2011.02.017  1
2011 Kahle KT, Walcott BP, Nahed BV, Barnard ZR, Lo EH, Buonanno FS, Venna N, Ning M. Cerebral edema and a transtentorial brain herniation syndrome associated with pandemic swine influenza A (H1N1) virus infection. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. 18: 1245-8. PMID 21742505 DOI: 10.1016/j.jocn.2011.01.014  1
2011 Rinehart J, Vázquez N, Kahle KT, Hodson CA, Ring AM, Gulcicek EE, Louvi A, Bobadilla NA, Gamba G, Lifton RP. WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters. The Journal of Biological Chemistry. 286: 30171-80. PMID 21733846 DOI: 10.1074/jbc.M111.222893  1
2011 Walcott BP, Nahed BV, Kahle KT, Redjal N, Coumans JV. Determination of geographic variance in stroke prevalence using Internet search engine analytics. Neurosurgical Focus. 30: E19. PMID 21631220 DOI: 10.3171/2011.2.FOCUS1124  1
2011 Walcott BP, Kahle KT, Wain JC, Borges LF. Giant thoracic meningocele associated with neurofibromatosis 1. Neurology. 76: 1943. PMID 21624995 DOI: 10.1212/WNL.0b013e31821d7667  1
2011 Walcott BP, Pisapia JM, Nahed BV, Kahle KT, Ogilvy CS. Early experience with flow diverting endoluminal stents for the treatment of intracranial aneurysms. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. 18: 891-4. PMID 21571535 DOI: 10.1016/j.jocn.2011.01.002  1
2011 Stapleton CJ, Walcott BP, Linskey KR, Kahle KT, Nahed BV, Asaad WF. Temporal bone chondroblastoma with secondary aneurysmal bone cyst presenting as an intracranial mass with clinical seizure activity. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. 18: 857-60. PMID 21514167 DOI: 10.1016/j.jocn.2010.11.004  1
2011 Nahed BV, Ferreira M, Babu MA, Terry AR, Walcott BP, Kahle KT, Smith ER. Dural scalp and intracranial hemangiomas causing hydrocephalus and venous sinus thrombosis in an infant. Journal of Child Neurology. 26: 777-81. PMID 21325128 DOI: 10.1177/0883073810390694  1
2011 Coumans JV, Walcott BP, Redjal N, Kahle KT, Nahed BV. En bloc excision of a dermal sinus tract. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. 18: 554-8. PMID 21316971 DOI: 10.1016/j.jocn.2010.11.008  1
2011 Walcott BP, Hanak BW, Caracci JR, Redjal N, Nahed BV, Kahle KT, Coumans JV. Trends in inpatient setting laminectomy for excision of herniated intervertebral disc: Population-based estimates from the US nationwide inpatient sample. Surgical Neurology International. 2: 7. PMID 21297929 DOI: 10.4103/2152-7806.76144  1
2011 Kahle KT, Walcott BP, Staley KJ. Resolution of headache and papilledema in idiopathic intracranial hypertension associated with inhibition of Na+-K+-2Cl- cotransport. Journal of Child Neurology. 26: 205-8. PMID 21285039 DOI: 10.1177/0883073810391264  1
2011 Simard JM, Sahuquillo J, Sheth KN, Kahle KT, Walcott BP. Managing malignant cerebral infarction. Current Treatment Options in Neurology. 13: 217-29. PMID 21190097 DOI: 10.1007/s11940-010-0110-9  1
2010 Dzhala VI, Kuchibhotla KV, Glykys JC, Kahle KT, Swiercz WB, Feng G, Kuner T, Augustine GJ, Bacskai BJ, Staley KJ. Progressive NKCC1-dependent neuronal chloride accumulation during neonatal seizures. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 11745-61. PMID 20810895 DOI: 10.1523/JNEUROSCI.1769-10.2010  1
2010 Kahle KT, Rinehart J, Lifton RP. Phosphoregulation of the Na-K-2Cl and K-Cl cotransporters by the WNK kinases. Biochimica Et Biophysica Acta. 1802: 1150-8. PMID 20637866 DOI: 10.1016/j.bbadis.2010.07.009  1
2010 Eichler AF, Kahle KT, Wang DL, Joshi VA, Willers H, Engelman JA, Lynch TJ, Sequist LV. EGFR mutation status and survival after diagnosis of brain metastasis in nonsmall cell lung cancer. Neuro-Oncology. 12: 1193-9. PMID 20627894 DOI: 10.1093/neuonc/noq076  1
2010 Nahed BV, Walcott BP, Ortman AJ, Kahle KT, Aghi M, Peterfreund RA, Coumans JV. Interval, acute onset airway obstruction associated with a fracture of the C4 vertebra in a patient with ankylosing spondylitis. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. 17: 1085-8. PMID 20580996 DOI: 10.1016/j.jocn.2009.12.010  1
2010 Hasbargen T, Ahmed MM, Miranpuri G, Li L, Kahle KT, Resnick D, Sun D. Role of NKCC1 and KCC2 in the development of chronic neuropathic pain following spinal cord injury. Annals of the New York Academy of Sciences. 1198: 168-72. PMID 20536931 DOI: 10.1111/j.1749-6632.2010.05462.x  0.36
2010 Naunheim MR, Nahed BV, Walcott BP, Kahle KT, Soupir CP, Cahill DP, Borges LF. Diagnosis of acute lymphoblastic leukemia from intracerebral hemorrhage and blast crisis. A case report and review of the literature. Clinical Neurology and Neurosurgery. 112: 575-7. PMID 20493628 DOI: 10.1016/j.clineuro.2010.04.001  1
2010 Kahle KT, Kozono D, Kimberly NG, Hsieh G, Zinn PO, Nitta M, Chen CC. Functional genomics to explore cancer cell vulnerabilities Neurosurgical Focus. 28: E5.1-E5.7. PMID 20043720 DOI: 10.3171/2009.10.FOCUS09212  1
2009 Kahle KT, Simard JM, Staley KJ, Nahed BV, Jones PS, Sun D. Molecular mechanisms of ischemic cerebral edema: role of electroneutral ion transport. Physiology (Bethesda, Md.). 24: 257-65. PMID 19675357 DOI: 10.1152/physiol.00015.2009  1
2009 Kahle KT, Barnett SM, Sassower KC, Staley KJ. Decreased seizure activity in a human neonate treated with bumetanide, an inhibitor of the Na(+)-K(+)-2Cl(-) cotransporter NKCC1. Journal of Child Neurology. 24: 572-6. PMID 19406757 DOI: 10.1177/0883073809333526  1
2009 Nahed BV, Ferreira M, Naunheim MR, Kahle KT, Proctor MR, Smith ER. Intracranial vasospasm with subsequent stroke after traumatic subarachnoid hemorrhage in a 22-month-old child. Journal of Neurosurgery. Pediatrics. 3: 311-5. PMID 19338410 DOI: 10.3171/2008.12.PEDS08206  1
2009 San-Cristobal P, Pacheco-Alvarez D, Richardson C, Ring AM, Vazquez N, Rafiqi FH, Chari D, Kahle KT, Leng Q, Bobadilla NA, Hebert SC, Alessi DR, Lifton RP, Gamba G. Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway. Proceedings of the National Academy of Sciences of the United States of America. 106: 4384-9. PMID 19240212 DOI: 10.1073/pnas.0813238106  1
2008 Kahle KT, Staley KJ, Nahed BV, Gamba G, Hebert SC, Lifton RP, Mount DB. Roles of the cation-chloride cotransporters in neurological disease. Nature Clinical Practice. Neurology. 4: 490-503. PMID 18769373 DOI: 10.1038/ncpneuro0883  1
2008 Kahle KT, Staley KJ. The bumetanide-sensitive Na-K-2Cl cotransporter NKCC1 as a potential target of a novel mechanism-based treatment strategy for neonatal seizures. Neurosurgical Focus. 25: E22. PMID 18759624 DOI: 10.3171/FOC/2008/25/9/E22  1
2008 Ponce-Coria J, San-Cristobal P, Kahle KT, Vazquez N, Pacheco-Alvarez D, de Los Heros P, Juárez P, Muñoz E, Michel G, Bobadilla NA, Gimenez I, Lifton RP, Hebert SC, Gamba G. Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases. Proceedings of the National Academy of Sciences of the United States of America. 105: 8458-63. PMID 18550832 DOI: 10.1073/pnas.0802966105  1
2008 Kahle KT, Rinehart J, Giebisch G, Gamba G, Hebert SC, Lifton RP. A novel protein kinase signaling pathway essential for blood pressure regulation in humans. Trends in Endocrinology and Metabolism: Tem. 19: 91-5. PMID 18280177 DOI: 10.1016/j.tem.2008.01.001  1
2008 Kahle KT, Ring AM, Lifton RP. Molecular physiology of the WNK kinases. Annual Review of Physiology. 70: 329-55. PMID 17961084 DOI: 10.1146/annurev.physiol.70.113006.100651  1
2007 Ring AM, Leng Q, Rinehart J, Wilson FH, Kahle KT, Hebert SC, Lifton RP. An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 104: 4025-9. PMID 17360471 DOI: 10.1073/pnas.0611728104  1
2007 Ring AM, Cheng SX, Leng Q, Kahle KT, Rinehart J, Lalioti MD, Volkman HM, Wilson FH, Hebert SC, Lifton RP. WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America. 104: 4020-4. PMID 17360470 DOI: 10.1073/pnas.0611727104  1
2006 Kahle KT, Rinehart J, Ring A, Gimenez I, Gamba G, Hebert SC, Lifton RP. WNK protein kinases modulate cellular Cl- flux by altering the phosphorylation state of the Na-K-Cl and K-Cl cotransporters. Physiology (Bethesda, Md.). 21: 326-35. PMID 16990453 DOI: 10.1152/physiol.00015.2006  1
2006 Lalioti MD, Zhang J, Volkman HM, Kahle KT, Hoffmann KE, Toka HR, Nelson-Williams C, Ellison DH, Flavell R, Booth CJ, Lu Y, Geller DS, Lifton RP. Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule. Nature Genetics. 38: 1124-32. PMID 16964266 DOI: 10.1038/ng1877  1
2006 de Los Heros P, Kahle KT, Rinehart J, Bobadilla NA, Vázquez N, San Cristobal P, Mount DB, Lifton RP, Hebert SC, Gamba G. WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathway. Proceedings of the National Academy of Sciences of the United States of America. 103: 1976-81. PMID 16446421 DOI: 10.1073/pnas.0510947103  1
2006 Leng Q, Kahle KT, Rinehart J, MacGregor GG, Wilson FH, Canessa CM, Lifton RP, Hebert SC. WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1). The Journal of Physiology. 571: 275-86. PMID 16357011 DOI: 10.1113/jphysiol.2005.102202  1
2005 Rinehart J, Kahle KT, de Los Heros P, Vazquez N, Meade P, Wilson FH, Hebert SC, Gimenez I, Gamba G, Lifton RP. WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 102: 16777-82. PMID 16275913 DOI: 10.1073/pnas.0508303102  1
2005 Kahle KT, Rinehart J, de Los Heros P, Louvi A, Meade P, Vazquez N, Hebert SC, Gamba G, Gimenez I, Lifton RP. WNK3 modulates transport of Cl- in and out of cells: implications for control of cell volume and neuronal excitability. Proceedings of the National Academy of Sciences of the United States of America. 102: 16783-8. PMID 16275911 DOI: 10.1073/pnas.0508307102  1
2005 Nahed BV, DiLuna ML, Morgan T, Ocal E, Hawkins AA, Ozduman K, Kahle KT, Chamberlain A, Amar AP, Gunel M. Hypertension, age, and location predict rupture of small intracranial aneurysms. Neurosurgery. 57: 676-83; discussion 6. PMID 16239879  1
2005 Kahle KT, Wilson FH, Lifton RP. Regulation of diverse ion transport pathways by WNK4 kinase: A novel molecular switch Trends in Endocrinology and Metabolism. 16: 98-103. PMID 15808806 DOI: 10.1016/j.tem.2005.02.012  1
2004 Kahle KT, MacGregor GG, Wilson FH, Van Hoek AN, Brown D, Ardito T, Kashgarian M, Giebisch G, Hebert SC, Boulpaep EL, Lifton RP. Paracellular Cl- permeability is regulated by WNK4 kinase: Insight into normal physiology and hypertension Proceedings of the National Academy of Sciences of the United States of America. 101: 14877-14882. PMID 15465913 DOI: 10.1073/pnas.0406172101  1
2004 Kahle KT, Wilson FH, Lalioti M, Toka H, Qin H, Lifton RP. WNK kinases: molecular regulators of integrated epithelial ion transport. Current Opinion in Nephrology and Hypertension. 13: 557-62. PMID 15300163 DOI: 10.1097/00041552-200409000-00012  1
2004 Kahle KT, Gimenez I, Hassan H, Wilson FH, Wong RD, Forbush B, Aronson PS, Lifton RP. WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia Proceedings of the National Academy of Sciences of the United States of America. 101: 2064-2069. PMID 14769928 DOI: 10.1073/pnas.0308434100  1
2003 Kahle KT, Wilson FH, Leng Q, Lalioti MD, O'Connell AD, Dong K, Rapson AK, MacGregor GG, Giebisch G, Hebert SC, Lifton RP. WNK4 regulates the balance between renal NaCl reabsorption and K + secretion Nature Genetics. 35: 372-376. PMID 14608358 DOI: 10.1038/ng1271  1
2003 Choate KA, Kahle KT, Wilson FH, Nelson-Williams C, Lifton RP. WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl--transporting epithelia Proceedings of the National Academy of Sciences of the United States of America. 100: 663-668. PMID 12522152 DOI: 10.1073/pnas.242728499  1
2003 Wilson FH, Kahle KT, Sabath E, Lalioti MD, Rapson AK, Hoover RS, Hebert SC, Gamba G, Lifton RP. Molecular pathogenesis of inherited hypertension with hyperkalemia: The Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4 Proceedings of the National Academy of Sciences of the United States of America. 100: 680-684. PMID 12515852 DOI: 10.1073/pnas.242735399  1
2002 Abe MK, Saelzler MP, Espinosa R, Kahle KT, Hershenson MB, Le Beau MM, Rosner MR. ERK8, a new member of the mitogen-activated protein kinase family. The Journal of Biological Chemistry. 277: 16733-43. PMID 11875070 DOI: 10.1074/jbc.M112483200  1
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