Kristopher T. Kahle, Ph.D. - Publications

2007 Yale University, New Haven, CT 
Physiology Biology, Genetics

123 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Singh AK, Allington G, Viviano S, McGee S, Kiziltug E, Ma S, Zhao S, Mekbib KY, Shohfi JP, Duy PQ, DeSpenza T, Furey CG, Reeves BC, Smith H, Sousa AMM, ... ... Kahle KT, et al. A novel SMARCC1 BAFopathy implicates neural progenitor epigenetic dysregulation in human hydrocephalus. Brain : a Journal of Neurology. PMID 38128548 DOI: 10.1093/brain/awad405  0.446
2023 Zhao S, Mekbib KY, van der Ent MA, Allington G, Prendergast A, Chau JE, Smith H, Shohfi J, Ocken J, Duran D, Furey CG, Hao LT, Duy PQ, Reeves BC, Zhang J, ... ... Kahle KT, et al. Mutation of key signaling regulators of cerebrovascular development in vein of Galen malformations. Nature Communications. 14: 7452. PMID 37978175 DOI: 10.1038/s41467-023-43062-z  0.46
2023 Khoshkhoo S, Wang Y, Chahine Y, Erson-Omay EZ, Robert SM, Kiziltug E, Damisah EC, Nelson-Williams C, Zhu G, Kong W, Huang AY, Stronge E, Phillips HW, Chhouk BH, Bizzotto S, ... ... Kahle KT, et al. Contribution of Somatic Ras/Raf/Mitogen-Activated Protein Kinase Variants in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy. Jama Neurology. PMID 37126322 DOI: 10.1001/jamaneurol.2023.0473  0.415
2023 Timberlake AT, McGee S, Allington G, Kiziltug E, Wolfe EM, Stiegler AL, Boggon TJ, Sanyoura M, Morrow M, Wenger TL, Fernandes EM, Caluseriu O, Persing JA, Jin SC, Lifton RP, ... Kahle KT, et al. De novo variants implicate chromatin modification, transcriptional regulation, and retinoic acid signaling in syndromic craniosynostosis. American Journal of Human Genetics. PMID 37086723 DOI: 10.1016/j.ajhg.2023.03.017  0.424
2023 Singh AK, Viviano S, Allington G, McGee S, Kiziltug E, Mekbib KY, Shohfi JP, Duy PQ, DeSpenza T, Furey CG, Reeves BC, Smith H, Ma S, Sousa AMM, Cherskov A, ... ... Kahle KT, et al. A novel -mutant BAFopathy implicates epigenetic dysregulation of neural progenitors in hydrocephalus. Medrxiv : the Preprint Server For Health Sciences. PMID 36993720 DOI: 10.1101/2023.03.19.23287455  0.418
2023 Zhao S, Mekbib KY, van der Ent MA, Allington G, Prendergast A, Chau JE, Smith H, Shohfi J, Ocken J, Duran D, Furey CG, Le HT, Duy PQ, Reeves BC, Zhang J, ... ... Kahle KT, et al. Genetic dysregulation of an endothelial Ras signaling network in vein of Galen malformations. Biorxiv : the Preprint Server For Biology. PMID 36993588 DOI: 10.1101/2023.03.18.532837  0.434
2023 Kundishora AJ, Allington G, McGee S, Mekbib KY, Gainullin V, Timberlake AT, Nelson-Williams C, Kiziltug E, Smith H, Ocken J, Shohfi J, Allocco A, Duy PQ, Elsamadicy AA, Dong W, ... ... Kahle KT, et al. Multiomic analyses implicate a neurodevelopmental program in the pathogenesis of cerebral arachnoid cysts. Nature Medicine. PMID 36879130 DOI: 10.1038/s41591-023-02238-2  0.435
2023 Robert SM, Reeves BC, Kiziltug E, Duy PQ, Karimy JK, Mansuri MS, Marlier A, Allington G, Greenberg ABW, DeSpenza T, Singh AK, Zeng X, Mekbib KY, Kundishora AJ, Nelson-Williams C, ... ... Kahle KT, et al. The choroid plexus links innate immunity to CSF dysregulation in hydrocephalus. Cell. 186: 764-785.e21. PMID 36803604 DOI: 10.1016/j.cell.2023.01.017  0.591
2022 Timberlake AT, Kiziltug E, Jin SC, Nelson-Williams C, Loring E, Allocco A, Marlier A, Banka S, Stuart H, Passos-Buenos MR, Rosa R, Rogatto SR, Tonne E, Stiegler AL, Boggon TJ, ... ... Kahle KT, et al. De novo mutations in the BMP signaling pathway in lambdoid craniosynostosis. Human Genetics. PMID 35997807 DOI: 10.1007/s00439-022-02477-2  0.448
2022 Duy PQ, Timberlake AT, Lifton RP, Kahle KT. Molecular genetics of human developmental neurocranial anomalies: towards "precision surgery". Cerebral Cortex (New York, N.Y. : 1991). PMID 35739418 DOI: 10.1093/cercor/bhac249  0.427
2022 Küry S, Zhang J, Besnard T, Caro-Llopis A, Zeng X, Robert SM, Josiah SS, Kiziltug E, Denommé-Pichon AS, Cogné B, Kundishora AJ, Hao LT, Li H, Stevenson RE, Louie RJ, ... ... Kahle KT, et al. Rare pathogenic variants in WNK3 cause X-linked intellectual disability. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 35678782 DOI: 10.1016/j.gim.2022.05.009  0.786
2022 Wang J, Liu R, Hasan MN, Fischer S, Chen Y, Como M, Fiesler VM, Bhuiyan MIH, Dong S, Li E, Kahle KT, Zhang J, Deng X, Subramanya AR, Begum G, et al. Role of SPAK-NKCC1 signaling cascade in the choroid plexus blood-CSF barrier damage after stroke. Journal of Neuroinflammation. 19: 91. PMID 35413993 DOI: 10.1186/s12974-022-02456-4  0.492
2022 Duy PQ, Weise SC, Marini C, Li XJ, Liang D, Dahl PJ, Ma S, Spajic A, Dong W, Juusola J, Kiziltug E, Kundishora AJ, Koundal S, Pedram MZ, Torres-Fernández LA, ... ... Kahle KT, et al. Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus. Nature Neuroscience. PMID 35379995 DOI: 10.1038/s41593-022-01043-3  0.448
2022 Bhuiyan MIH, Young CB, Jahan I, Hasan MN, Fischer S, Meor Azlan NF, Liu M, Chattopadhyay A, Huang H, Kahle KT, Zhang J, Poloyac SM, Molyneaux BJ, Straub AC, Deng X, et al. NF-κB Signaling-Mediated Activation of WNK-SPAK-NKCC1 Cascade in Worsened Stroke Outcomes of Ang II-Hypertensive Mice. Stroke. STROKEAHA121038351. PMID 35272484 DOI: 10.1161/STROKEAHA.121.038351  0.775
2021 Barak T, Ristori E, Ercan-Sencicek AG, Miyagishima DF, Nelson-Williams C, Dong W, Jin SC, Prendergast A, Armero W, Henegariu O, Erson-Omay EZ, Harmancı AS, Guy M, Gültekin B, Kilic D, ... ... Kahle KT, et al. PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humans. Nature Medicine. 27: 2165-2175. PMID 34887573 DOI: 10.1038/s41591-021-01572-7  0.477
2021 Kundishora AJ, Peters ST, Pinard A, Duran D, Panchagnula S, Barak T, Miyagishima DF, Dong W, Smith H, Ocken J, Dunbar A, Nelson-Williams C, Haider S, Walker RL, Li B, ... ... Kahle KT, et al. DIAPH1 Variants in Non-East Asian Patients With Sporadic Moyamoya Disease. Jama Neurology. PMID 34125151 DOI: 10.1001/jamaneurol.2021.1681  0.42
2020 Dong W, Jin SC, Allocco A, Zeng X, Sheth AH, Panchagnula S, Castonguay A, Lorenzo LÉ, Islam B, Brindle G, Bachand K, Hu J, Sularz A, Gaillard J, Choi J, ... ... Kahle KT, et al. Exome Sequencing Implicates Impaired GABA Signaling and Neuronal Ion Transport in Trigeminal Neuralgia. Iscience. 23: 101552. PMID 33083721 DOI: 10.1016/J.Isci.2020.101552  0.518
2020 Jin SC, Dong W, Kundishora AJ, Panchagnula S, Moreno-De-Luca A, Furey CG, Allocco AA, Walker RL, Nelson-Williams C, Smith H, Dunbar A, Conine S, Lu Q, Zeng X, Sierant MC, ... ... Kahle KT, et al. Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus. Nature Medicine. PMID 33077954 DOI: 10.1038/s41591-020-1090-2  0.456
2020 Robert SM, Reeves BC, Alper SL, Zhang J, Kahle KT. New drugs on the horizon for cerebral edema: what's in the clinical development pipeline? Expert Opinion On Investigational Drugs. PMID 32815401 DOI: 10.1080/13543784.2020.1813715  0.513
2020 Hong CS, Vasquez JC, Kundishora AJ, Elsamadicy AA, Beckta JM, Sule A, Marks AM, Leelatian N, Huttner A, Bindra RS, DiLuna ML, Kahle KT, Erson-Omay EZ. Persistent mutation despite multimodal therapy in recurrent pediatric glioblastoma. Npj Genomic Medicine. 5: 23. PMID 32528726 DOI: 10.1038/S41525-020-0130-7  0.316
2020 Duy PQ, He M, He Z, Kahle KT. Preclinical insights into therapeutic targeting of KCC2 for disorders of neuronal hyperexcitability. Expert Opinion On Therapeutic Targets. PMID 32336175 DOI: 10.1080/14728222.2020.1762174  0.301
2020 Karimy JK, Reeves BC, Kahle KT. Targeting TLR4-dependent inflammation in post-hemorrhagic brain injury. Expert Opinion On Therapeutic Targets. 1-9. PMID 32249624 DOI: 10.1080/14728222.2020.1752182  0.311
2020 Karimy JK, Reeves BC, Damisah E, Duy PQ, Antwi P, David W, Wang K, Schiff SJ, Limbrick DD, Alper SL, Warf BC, Nedergaard M, Simard JM, Kahle KT. Inflammation in acquired hydrocephalus: pathogenic mechanisms and therapeutic targets. Nature Reviews. Neurology. PMID 32152460 DOI: 10.1038/S41582-020-0321-Y  0.313
2020 Zhang J, Bhuiyan MIH, Zhang T, Karimy JK, Wu Z, Fiesler VM, Zhang J, Huang H, Hasan MN, Skrzypiec AE, Mucha M, Duran D, Huang W, Pawlak R, Foley LM, ... ... Kahle KT, et al. Modulation of brain cation-Cl cotransport via the SPAK kinase inhibitor ZT-1a. Nature Communications. 11: 78. PMID 31911626 DOI: 10.1038/S41467-019-13851-6  0.561
2019 Duy PQ, David WB, Kahle KT. Identification of KCC2 Mutations in Human Epilepsy Suggests Strategies for Therapeutic Transporter Modulation. Frontiers in Cellular Neuroscience. 13: 515. PMID 31803025 DOI: 10.3389/Fncel.2019.00515  0.356
2019 Fomchenko EI, Erson-Omay EZ, Kundishora AJ, Hong CS, Daniel AA, Allocco A, Duy PQ, Darbinyan A, Marks AM, DiLuna ML, Kahle KT, Huttner A. Genomic alterations underlying spinal metastases in pediatric H3K27M-mutant pineal parenchymal tumor of intermediate differentiation: case report. Journal of Neurosurgery. Pediatrics. 1-10. PMID 31653819 DOI: 10.3171/2019.8.Peds18664  0.309
2019 Allocco AA, Jin SC, Duy PQ, Furey CG, Zeng X, Dong W, Nelson-Williams C, Karimy JK, DeSpenza T, Hao LT, Reeves B, Haider S, Gunel M, Lifton RP, Kahle KT. Recessive Inheritance of Congenital Hydrocephalus With Other Structural Brain Abnormalities Caused by Compound Heterozygous Mutations in . Frontiers in Cellular Neuroscience. 13: 425. PMID 31616254 DOI: 10.3389/Fncel.2019.00425  0.55
2019 Watanabe M, Zhang J, Mansuri MS, Duan J, Karimy JK, Delpire E, Alper SL, Lifton RP, Fukuda A, Kahle KT. Developmentally regulated KCC2 phosphorylation is essential for dynamic GABA-mediated inhibition and survival. Science Signaling. 12. PMID 31615901 DOI: 10.1126/Scisignal.Aaw9315  0.657
2019 Pisella LI, Gaiarsa JL, Diabira D, Zhang J, Khalilov I, Duan J, Kahle KT, Medina I. Impaired regulation of KCC2 phosphorylation leads to neuronal network dysfunction and neurodevelopmental pathology. Science Signaling. 12. PMID 31615899 DOI: 10.1126/Scisignal.Aay0300  0.526
2019 Lanni JS, Peal D, Ekstrom L, Chen H, Stanclift C, Bowen ME, Mercado A, Gamba G, Kahle KT, Harris MP. Integrated K+ channel and K+Cl- cotransporter function are required for the coordination of size and proportion during development. Developmental Biology. PMID 31472116 DOI: 10.1016/J.Ydbio.2019.08.016  0.369
2019 Jin SC, Furey CG, Zeng X, Allocco A, Nelson-Williams C, Dong W, Karimy JK, Wang K, Ma S, Delpire E, Kahle KT. SLC12A ion transporter mutations in sporadic and familial human congenital hydrocephalus. Molecular Genetics & Genomic Medicine. e892. PMID 31393094 DOI: 10.1002/Mgg3.892  0.307
2019 Huang H, Song S, Banerjee S, Jiang T, Zhang J, Kahle KT, Sun D, Zhang Z. The WNK-SPAK/OSR1 Kinases and the Cation-Chloride Cotransporters as Therapeutic Targets for Neurological Diseases. Aging and Disease. 10: 626-636. PMID 31165006 DOI: 10.14336/Ad.2018.0928  0.626
2019 Duy PQ, Furey CG, Kahle KT. Trim71/lin-41 Links an Ancient miRNA Pathway to Human Congenital Hydrocephalus. Trends in Molecular Medicine. PMID 30975633 DOI: 10.1016/J.Molmed.2019.03.004  0.307
2019 Zeng X, Hunt A, Jin SC, Duran D, Gaillard J, Kahle KT. EphrinB2-EphB4-RASA1 Signaling in Human Cerebrovascular Development and Disease. Trends in Molecular Medicine. PMID 30819650 DOI: 10.1016/J.Molmed.2019.01.009  0.354
2019 Phan D, Foster D, Jux B, Lake E, Constable T, Kolanus W, Slack F, Kahle KT. Trim71 Links an Ancient MicroRNA Pathway to Neural Stem Cell Development and Human Congenital Hydrocephalus Neurosurgery. 66. DOI: 10.1093/Neuros/Nyz310_649  0.33
2019 Kundishora A, Zeng X, Duran D, Allocco AA, Choi J, Jin SC, Conine SB, Nelson-Williams C, Gaillard J, Furey CG, Timberlake AT, Mansuri M, Sorscher M, Klein J, Lu Q, ... ... Kahle KT, et al. Exome Sequencing Defines the Molecular Pathogenesis of Vein of Galen Malformation Neurosurgery. 66. DOI: 10.1093/Neuros/Nyz310_341  0.538
2019 Allocco AA, Jin SC, Dong W, Zeng X, Conine SB, Furey CG, Date PP, Gaillard J, Nelson-Williams C, Dunbar A, DeSpenza T, Deniz E, Khokha MK, Lifton RP, Kahle KT. Exome Sequencing Implicates SWI/SNF Chromatin Remodeling Genes in Human Congenital Hydrocephalus Neurosurgery. 66. DOI: 10.1093/Neuros/Nyz310_133  0.514
2018 Duran D, Zeng X, Jin SC, Choi J, Nelson-Williams C, Yatsula B, Gaillard J, Furey CG, Lu Q, Timberlake AT, Dong W, Sorscher MA, Loring E, Klein J, Allocco A, ... ... Kahle KT, et al. Mutations in Chromatin Modifier and Ephrin Signaling Genes in Vein of Galen Malformation. Neuron. PMID 30578106 DOI: 10.1016/J.Neuron.2018.11.041  0.635
2018 Furey CG, Zeng X, Dong W, Jin SC, Choi J, Timberlake AT, Dunbar AM, Allocco AA, Günel M, Lifton RP, Kahle KT. Human genetics and molecular mechanisms of congenital hydrocephalus. World Neurosurgery. PMID 30205212 DOI: 10.1016/J.Wneu.2018.09.018  0.457
2018 Furey CG, Choi J, Jin SC, Zeng X, Timberlake AT, Nelson-Williams C, Mansuri MS, Lu Q, Duran D, Panchagnula S, Allocco A, Karimy JK, Khanna A, Gaillard JR, DeSpenza T, ... ... Kahle KT, et al. De Novo Mutation in Genes Regulating Neural Stem Cell Fate in Human Congenital Hydrocephalus. Neuron. PMID 29983323 DOI: 10.1016/J.Neuron.2018.06.019  0.508
2018 Walcott BP, Winkler EA, Zhou S, Birk H, Guo D, Koch MJ, Stapleton CJ, Spiegelman D, Dionne-Laporte A, Dion PA, Kahle KT, Rouleau GA, Lawton MT. Identification of a rare pathway mutation in a non-syndromic human brain arteriovenous malformation via exome sequencing. Human Genome Variation. 5: 18001. PMID 29844917 DOI: 10.1038/Hgv.2018.1  0.357
2018 Duran D, Karschnia P, Gaillard JR, Karimy JK, Youngblood MW, DiLuna ML, Matouk CC, Aagaard-Kienitz B, Smith ER, Orbach DB, Rodesch G, Berenstein A, Gunel M, Kahle KT. Human genetics and molecular mechanisms of vein of Galen malformation. Journal of Neurosurgery. Pediatrics. 1-8. PMID 29350590 DOI: 10.3171/2017.9.Peds17365  0.339
2018 Furey CG, Jin SC, Timberlake AT, Choi J, Zeng X, Nelson-Williams C, Mansuri M, Lu Q, Duran D, Panchagnula S, Alloco A, Karimy JK, Gaillard J, Khanna A, Butler W, ... ... Kahle KT, et al. 125 De Novo Mutations in Genes Regulating Neural Stem Cell Fate in Human Congenital Hydrocephalus Neurosurgery. 65: 88-89. DOI: 10.1093/Neuros/Nyy303.125  0.495
2017 Heubl M, Zhang J, Pressey JC, Al Awabdh S, Renner M, Gomez-Castro F, Moutkine I, Eugène E, Russeau M, Kahle KT, Poncer JC, Lévi S. GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl--sensitive WNK1 kinase. Nature Communications. 8: 1776. PMID 29176664 DOI: 10.1038/S41467-017-01749-0  0.58
2017 Timberlake AT, Furey CG, Choi J, Nelson-Williams C, Loring E, Galm A, Kahle KT, Steinbacher DM, Larysz D, Persing JA, Lifton RP. De novo mutations in inhibitors of Wnt, BMP, and Ras/ERK signaling pathways in non-syndromic midline craniosynostosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 28808027 DOI: 10.1073/Pnas.1709255114  0.523
2017 Karimy JK, Zhang J, Kurland DB, Theriault BC, Duran D, Stokum JA, Furey CG, Zhou X, Mansuri MS, Montejo J, Vera A, DiLuna ML, Delpire E, Alper SL, Gunel M, ... ... Kahle KT, et al. Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus. Nature Medicine. PMID 28692063 DOI: 10.1038/Nm.4361  0.55
2017 Zhang J, Karimy JK, Delpire E, Kahle KT. Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport. Expert Opinion On Therapeutic Targets. PMID 28679296 DOI: 10.1080/14728222.2017.1351949  0.609
2017 Glykys J, Dzhala V, Egawa K, Kahle KT, Delpire E, Staley K. Chloride Dysregulation, Seizures, and Cerebral Edema: A Relationship with Therapeutic Potential. Trends in Neurosciences. PMID 28431741 DOI: 10.1016/J.Tins.2017.03.006  0.346
2017 Shekarabi M, Zhang J, Khanna AR, Ellison DH, Delpire E, Kahle KT. WNK Kinase Signaling in Ion Homeostasis and Human Disease. Cell Metabolism. 25: 285-299. PMID 28178566 DOI: 10.1016/J.Cmet.2017.01.007  0.594
2017 Karimy JK, Zhang J, Kurland DB, Theriault BC, Duran D, Furey CG, Gerzanich V, Simard JM, Kahle KT. 166 TLR-4-Regulated Cerebrospinal Fluid Hypersecretion in Post-Hemorrhagic Hydrocephalus Neurosurgery. 64: 242-242. DOI: 10.1093/Neuros/Nyx417.166  0.535
2017 Furey CG, Choi J, Duran D, Timberlake AT, Zeng X, Nelson-Williams C, Khanna A, Iskandar B, Butler W, Heuer GG, Bayri Y, Sahin Y, Limbrick DD, Warf BC, Duncan CC, ... ... Kahle KT, et al. 102 Exome Sequencing Identifies Novel Molecular Determinants of Human Congenital Hydrocephalus Neurosurgery. 64: 220-220. DOI: 10.1093/Neuros/Nyx417.102  0.499
2016 Davoli T, Mengwasser KE, Duan J, Chen T, Christensen C, Wooten EC, Anselmo AN, Li MZ, Wong KK, Kahle KT, Elledge SJ. Functional genomics reveals that tumors with activating phosphoinositide 3-kinase mutations are dependent on accelerated protein turnover. Genes & Development. 30: 2684-2695. PMID 28087713 DOI: 10.1101/Gad.290122.116  0.544
2016 Duran D, Jin SC, DeSpenza T, Nelson-Williams C, Cogal AG, Abrash EW, Harris PC, Lieske JC, Shimshak SJ, Mane S, Bilguvar K, DiLuna ML, Günel M, Lifton RP, Kahle KT. Digenic mutations of human OCRL paralogs in Dent's disease type 2 associated with Chiari I malformation. Human Genome Variation. 3: 16042. PMID 28018608 DOI: 10.1038/Hgv.2016.42  0.523
2016 Zhang J, Deng X, Kahle KT. Leveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition. Science Signaling. 9: pe3. PMID 27811182 DOI: 10.1126/Scisignal.Aaj2227  0.592
2016 Karimy JK, Duran D, Hu JK, Gavankar C, Gaillard JR, Bayri Y, Rice H, DiLuna ML, Gerzanich V, Marc Simard J, Kahle KT. Cerebrospinal fluid hypersecretion in pediatric hydrocephalus. Neurosurgical Focus. 41: E10. PMID 27798982 DOI: 10.3171/2016.8.Focus16278  0.347
2016 Bhuiyan MI, Song S, Yuan H, Begum G, Kofler J, Kahle KT, Yang SS, Lin SH, Alper SL, Subramanya AR, Sun D. WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 27798271 DOI: 10.1177/0271678X16675368  0.346
2016 Zhang J, Gao G, Begum G, Wang J, Khanna AR, Shmukler BE, Daubner GM, de Los Heros P, Davies P, Varghese J, Bhuiyan MI, Duan J, Zhang J, Duran D, Alper SL, ... ... Kahle KT, et al. Functional kinomics establishes a critical node of volume-sensitive cation-Cl(-) cotransporter regulation in the mammalian brain. Scientific Reports. 6: 35986. PMID 27782176 DOI: 10.1038/Srep35986  0.755
2016 Kahle KT, Flores B, Bharucha-Goebel D, Zhang J, Donkervoort S, Hegde M, Hussain G, Duran D, Liang B, Sun D, Bönnemann CG, Delpire E. Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporter. Science Signaling. 9: ra77. PMID 27485015 DOI: 10.1126/Scisignal.Aae0546  0.612
2016 Kahle KT, Khanna AR, Duan J, Staley KJ, Delpire E, Poduri A. The KCC2 Cotransporter and Human Epilepsy: Getting Excited About Inhibition. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. PMID 27130838 DOI: 10.1177/1073858416645087  0.344
2016 Kahle KT, Schmouth JF, Lavastre V, Latremoliere A, Zhang J, Andrews N, Omura T, Laganière J, Rochefort D, Hince P, Castonguay G, Gaudet R, Mapplebeck JC, Sotocinal SG, Duan J, et al. Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition. Science Signaling. 9: ra32. PMID 27025876 DOI: 10.1126/Scisignal.Aad0163  0.535
2016 Merner ND, Mercado A, Khanna AR, Hodgkinson A, Bruat V, Awadalla P, Gamba G, Rouleau GA, Kahle KT. Gain-of-function missense variant in SLC12A2, encoding the bumetanide-sensitive NKCC1 cotransporter, identified in human schizophrenia. Journal of Psychiatric Research. 77: 22-26. PMID 26955005 DOI: 10.1016/J.Jpsychires.2016.02.016  0.339
2016 Zhao H, Nepomuceno R, Gao X, Foley LM, Wang S, Begum G, Zhu W, Pigott VM, Falgoust LM, Kahle KT, Yang SS, Lin SH, Alper SL, Kevin Hitchens T, Hu S, et al. Deletion of the WNK3-SPAK kinase complex in mice improves radiographic and clinical outcomes in malignant cerebral edema after ischemic stroke. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 26861815 DOI: 10.1177/0271678X16631561  0.329
2015 Merner ND, Chandler MR, Bourassa C, Liang B, Khanna AR, Dion P, Rouleau GA, Kahle KT. Regulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophrenia. Frontiers in Cellular Neuroscience. 9: 386. PMID 26528127 DOI: 10.3389/Fncel.2015.00386  0.322
2015 Kahle KT, Delpire E. Kinase-KCC2 coupling: Cl- rheostasis, disease susceptibility, therapeutic target. Journal of Neurophysiology. jn.00865.2015. PMID 26510764 DOI: 10.1152/Jn.00865.2015  0.444
2015 Kahle KT, Kulkarni AV, Limbrick DD, Warf BC. Hydrocephalus in children. Lancet (London, England). PMID 26256071 DOI: 10.1016/S0140-6736(15)60694-8  0.305
2015 Adragna NC, Ravilla NB, Lauf PK, Begum G, Khanna AR, Sun D, Kahle KT. Regulated phosphorylation of the K-Cl cotransporter KCC3 is a molecular switch of intracellular potassium content and cell volume homeostasis. Frontiers in Cellular Neuroscience. 9: 255. PMID 26217182 DOI: 10.3389/Fncel.2015.00255  0.438
2015 Kahle KT, Khanna AR, Alper SL, Adragna NC, Lauf PK, Sun D, Delpire E. K-Cl cotransporters, cell volume homeostasis, and neurological disease. Trends in Molecular Medicine. 21: 513-23. PMID 26142773 DOI: 10.1016/J.Molmed.2015.05.008  0.434
2015 Friedel P, Kahle KT, Zhang J, Hertz N, Pisella LI, Buhler E, Schaller F, Duan J, Khanna AR, Bishop PN, Shokat KM, Medina I. WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons. Science Signaling. 8: ra65. PMID 26126716 DOI: 10.1126/Scisignal.Aaa0354  0.577
2015 Begum G, Yuan H, Kahle KT, Li L, Wang S, Shi Y, Shmukler BE, Yang SS, Lin SH, Alper SL, Sun D. Inhibition of WNK3 Kinase Signaling Reduces Brain Damage and Accelerates Neurological Recovery After Stroke. Stroke; a Journal of Cerebral Circulation. 46: 1956-65. PMID 26069258 DOI: 10.1161/Strokeaha.115.008939  0.425
2015 Campbell SL, Robel S, Cuddapah VA, Robert S, Buckingham SC, Kahle KT, Sontheimer H. GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy. Glia. 63: 23-36. PMID 25066727 DOI: 10.1002/Glia.22730  0.319
2015 Kahle KT, VanHook AM. Science SignalingPodcast: 30 June 2015 Science Signaling. 8: pc16-pc16. DOI: 10.1126/Scisignal.Aac8012  0.315
2014 Alessi DR, Zhang J, Khanna A, Hochdörfer T, Shang Y, Kahle KT. The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters. Science Signaling. 7: re3. PMID 25028718 DOI: 10.1126/Scisignal.2005365  0.721
2014 Kahle KT, Merner ND, Friedel P, Silayeva L, Liang B, Khanna A, Shang Y, Lachance-Touchette P, Bourassa C, Levert A, Dion PA, Walcott B, Spiegelman D, Dionne-Laporte A, Hodgkinson A, et al. Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy. Embo Reports. 15: 766-74. PMID 24928908 DOI: 10.15252/Embr.201438840  0.369
2014 Kahle KT, Khanna A, Clapham DE, Woolf CJ. Therapeutic restoration of spinal inhibition via druggable enhancement of potassium-chloride cotransporter KCC2-mediated chloride extrusion in peripheral neuropathic pain. Jama Neurology. 71: 640-5. PMID 24615367 DOI: 10.1001/Jamaneurol.2014.21  0.498
2014 Medina I, Friedel P, Rivera C, Kahle KT, Kourdougli N, Uvarov P, Pellegrino C. Current view on the functional regulation of the neuronal K(+)-Cl(-) cotransporter KCC2. Frontiers in Cellular Neuroscience. 8: 27. PMID 24567703 DOI: 10.3389/Fncel.2014.00027  0.398
2014 Zhu W, Begum G, Pointer K, Clark PA, Yang SS, Lin SH, Kahle KT, Kuo JS, Sun D. WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration. Molecular Cancer. 13: 31. PMID 24555568 DOI: 10.1186/1476-4598-13-31  0.417
2014 Glykys J, Dzhala V, Egawa K, Balena T, Saponjian Y, Kuchibhotla KV, Bacskai BJ, Kahle KT, Zeuthen T, Staley KJ. Local impermeant anions establish the neuronal chloride concentration. Science (New York, N.Y.). 343: 670-5. PMID 24503855 DOI: 10.1126/Science.1245423  0.338
2014 Sun D, Kahle KT. Dysregulation of diverse ion transport pathways controlling cell volume homoestasis contribute to neuroglial cell injury following ischemic stroke. Translational Stroke Research. 5: 1-2. PMID 24464825 DOI: 10.1007/S12975-014-0324-3  0.341
2014 de Los Heros P, Alessi DR, Gourlay R, Campbell DG, Deak M, Macartney TJ, Kahle KT, Zhang J. The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters. The Biochemical Journal. 458: 559-73. PMID 24393035 DOI: 10.1042/Bj20131478  0.71
2014 Khanna A, Walcott BP, Kahle KT, Simard JM. Effect of glibenclamide on the prevention of secondary brain injury following ischemic stroke in humans. Neurosurgical Focus. 36: E11. PMID 24380477 DOI: 10.3171/2013.10.Focus13404  0.311
2014 Khanna A, Kahle KT, Walcott BP, Gerzanich V, Simard JM. Disruption of ion homeostasis in the neurogliovascular unit underlies the pathogenesis of ischemic cerebral edema. Translational Stroke Research. 5: 3-16. PMID 24323726 DOI: 10.1007/S12975-013-0307-9  0.341
2014 Lee HK, Ahmed MM, King KC, Miranpuri GS, Kahle KT, Resnick DK, Sun D. Persistent phosphorylation of NKCC1 and WNK1 in the epicenter of the spinal cord following contusion injury. The Spine Journal : Official Journal of the North American Spine Society. 14: 777-81. PMID 24239489 DOI: 10.1016/J.Spinee.2013.06.100  0.328
2014 Kahle KT, Gao G, Zhang J, Latremoliere A, Andrews N, Shang Y, Alessi D, Woolf C, Elledge S, Clapham D. Ronald R. Tasker Young Investigator Award 165 Promoting Endogenous GABAergic Analgesia via Kinase Modulation of Neuronal Ion Plasticity Neurosurgery. 61: 214. DOI: 10.1227/01.Neu.0000452440.75411.82  0.683
2013 Kahle KT, Deeb TZ, Puskarjov M, Silayeva L, Liang B, Kaila K, Moss SJ. Modulation of neuronal activity by phosphorylation of the K-Cl cotransporter KCC2. Trends in Neurosciences. 36: 726-37. PMID 24139641 DOI: 10.1016/J.Tins.2013.08.006  0.44
2013 Khanna A, Walcott BP, Kahle KT. Limitations of Current GABA Agonists in Neonatal Seizures: Toward GABA Modulation Via the Targeting of Neuronal Cl(-) Transport. Frontiers in Neurology. 4: 78. PMID 23805124 DOI: 10.3389/Fneur.2013.00078  0.304
2013 Arroyo JP, Kahle KT, Gamba G. The SLC12 family of electroneutral cation-coupled chloride cotransporters. Molecular Aspects of Medicine. 34: 288-98. PMID 23506871 DOI: 10.1016/J.Mam.2012.05.002  0.34
2013 Li J, Zhu S, Kozono D, Futulan D, Gonda D, Kushwaha D, Kahle K, Elledge S, Chen CC. Abstract 4366: ShRNA-based cellular proliferation signaling analysis revealed DRD2 as a novel therapeutic target for glioblastoma. Cancer Research. 73: 4366-4366. DOI: 10.1158/1538-7445.Am2013-4366  0.522
2012 Algharabil J, Kintner DB, Wang Q, Begum G, Clark PA, Yang SS, Lin SH, Kahle KT, Kuo JS, Sun D. Inhibition of Na(+)-K(+)-2Cl(-) cotransporter isoform 1 accelerates temozolomide-mediated apoptosis in glioblastoma cancer cells. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 30: 33-48. PMID 22759954 DOI: 10.1159/000339047  0.374
2012 Ben-Ari Y, Khalilov I, Kahle KT, Cherubini E. The GABA excitatory/inhibitory shift in brain maturation and neurological disorders. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 18: 467-86. PMID 22547529 DOI: 10.1177/1073858412438697  0.335
2012 Kessler JD, Kahle KT, Sun T, Meerbrey KL, Schlabach MR, Schmitt EM, Skinner SO, Xu Q, Li MZ, Hartman ZC, Rao M, Yu P, Dominguez-Vidana R, Liang AC, Solimini NL, et al. A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. Science (New York, N.Y.). 335: 348-53. PMID 22157079 DOI: 10.1126/Science.1212728  0.694
2012 Walcott BP, Kahle KT, Simard JM. Novel treatment targets for cerebral edema. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 9: 65-72. PMID 22125096 DOI: 10.1007/S13311-011-0087-4  0.341
2012 Kessler JD, Kahle KT, Sun T, Meerbrey KL, Schlabach MR, Schmitt EM, Skinner SO, Xu Q, Li MZ, Hartman ZC, Rao M, Yu P, Dominguez-Vidana R, Liang AC, Solimini NL, et al. Abstract 3091: A sumoylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis Cancer Research. 72: 3091-3091. DOI: 10.1158/1538-7445.Am2012-3091  0.696
2011 Rinehart J, Vázquez N, Kahle KT, Hodson CA, Ring AM, Gulcicek EE, Louvi A, Bobadilla NA, Gamba G, Lifton RP. WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters. The Journal of Biological Chemistry. 286: 30171-80. PMID 21733846 DOI: 10.1074/Jbc.M111.222893  0.61
2011 Kahle KT, Walcott BP, Staley KJ. Resolution of headache and papilledema in idiopathic intracranial hypertension associated with inhibition of Na+-K+-2Cl- cotransport. Journal of Child Neurology. 26: 205-8. PMID 21285039 DOI: 10.1177/0883073810391264  0.311
2010 Wang Y, Suo H, Zheng Y, Liu K, Zhuang C, Kahle KT, Ma H, Yan X. The soybean root-specific protein kinase GmWNK1 regulates stress-responsive ABA signaling on the root system architecture. The Plant Journal : For Cell and Molecular Biology. 64: 230-42. PMID 20735771 DOI: 10.1111/J.1365-313X.2010.04320.X  0.379
2010 Kahle KT, Rinehart J, Lifton RP. Phosphoregulation of the Na-K-2Cl and K-Cl cotransporters by the WNK kinases. Biochimica Et Biophysica Acta. 1802: 1150-8. PMID 20637866 DOI: 10.1016/J.Bbadis.2010.07.009  0.628
2010 Kahle KT, Kozono D, Kimberly NG, Hsieh G, Zinn PO, Nitta M, Chen CC. Functional genomics to explore cancer cell vulnerabilities Neurosurgical Focus. 28: E5.1-E5.7. PMID 20043720 DOI: 10.3171/2009.10.Focus09212  0.301
2010 Simard JM, Kahle KT, Gerzanich V. Molecular mechanisms of microvascular failure in central nervous system injury--synergistic roles of NKCC1 and SUR1/TRPM4. Journal of Neurosurgery. 113: 622-9. PMID 20035575 DOI: 10.3171/2009.11.Jns081052  0.366
2009 Kahle KT, Simard JM, Staley KJ, Nahed BV, Jones PS, Sun D. Molecular mechanisms of ischemic cerebral edema: role of electroneutral ion transport. Physiology (Bethesda, Md.). 24: 257-65. PMID 19675357 DOI: 10.1152/Physiol.00015.2009  0.348
2009 San-Cristobal P, Pacheco-Alvarez D, Richardson C, Ring AM, Vazquez N, Rafiqi FH, Chari D, Kahle KT, Leng Q, Bobadilla NA, Hebert SC, Alessi DR, Lifton RP, Gamba G. Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway. Proceedings of the National Academy of Sciences of the United States of America. 106: 4384-9. PMID 19240212 DOI: 10.1073/Pnas.0813238106  0.704
2009 Kahle KT, Wilson FH, Lifton RP. The Syndrome of Hypertension and Hyperkalemia (Pseudohypoaldosteronism Type II): WNK Kinases Regulate the Balance Between Renal Salt Reabsorption and Potassium Secretion Genetic Diseases of the Kidney. 313-329. DOI: 10.1016/B978-0-12-449851-8.00019-X  0.729
2008 Kahle KT, Staley KJ, Nahed BV, Gamba G, Hebert SC, Lifton RP, Mount DB. Roles of the cation-chloride cotransporters in neurological disease. Nature Clinical Practice. Neurology. 4: 490-503. PMID 18769373 DOI: 10.1038/Ncpneuro0883  0.585
2008 Kahle KT, Staley KJ. The bumetanide-sensitive Na-K-2Cl cotransporter NKCC1 as a potential target of a novel mechanism-based treatment strategy for neonatal seizures. Neurosurgical Focus. 25: E22. PMID 18759624 DOI: 10.3171/Foc/2008/25/9/E22  0.343
2008 Ponce-Coria J, San-Cristobal P, Kahle KT, Vazquez N, Pacheco-Alvarez D, de Los Heros P, Juárez P, Muñoz E, Michel G, Bobadilla NA, Gimenez I, Lifton RP, Hebert SC, Gamba G. Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases. Proceedings of the National Academy of Sciences of the United States of America. 105: 8458-63. PMID 18550832 DOI: 10.1073/Pnas.0802966105  0.625
2008 Kahle KT, Staley K. Altered neuronal chloride homeostasis and excitatory GABAergic signaling in human temporal lobe epilepsy. Epilepsy Currents / American Epilepsy Society. 8: 51-3. PMID 18330470 DOI: 10.1111/J.1535-7511.2008.00235.X  0.373
2008 Kahle KT, Rinehart J, Giebisch G, Gamba G, Hebert SC, Lifton RP. A novel protein kinase signaling pathway essential for blood pressure regulation in humans. Trends in Endocrinology and Metabolism: Tem. 19: 91-5. PMID 18280177 DOI: 10.1016/J.Tem.2008.01.001  0.601
2008 Kahle KT, Ring AM, Lifton RP. Molecular physiology of the WNK kinases. Annual Review of Physiology. 70: 329-55. PMID 17961084 DOI: 10.1146/Annurev.Physiol.70.113006.100651  0.612
2008 Kahle KT, Ring AM, Lifton RP. Molecular physiology of the WNK kinases Annual Review of Physiology. 70: 329-355. DOI: 10.1146/annurev.physiol.70.113006.100651  0.458
2007 Ring AM, Leng Q, Rinehart J, Wilson FH, Kahle KT, Hebert SC, Lifton RP. An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 104: 4025-9. PMID 17360471 DOI: 10.1073/Pnas.0611728104  0.755
2007 Ring AM, Cheng SX, Leng Q, Kahle KT, Rinehart J, Lalioti MD, Volkman HM, Wilson FH, Hebert SC, Lifton RP. WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America. 104: 4020-4. PMID 17360470 DOI: 10.1073/Pnas.0611727104  0.776
2006 Kahle KT, Rinehart J, Ring A, Gimenez I, Gamba G, Hebert SC, Lifton RP. WNK protein kinases modulate cellular Cl- flux by altering the phosphorylation state of the Na-K-Cl and K-Cl cotransporters. Physiology (Bethesda, Md.). 21: 326-35. PMID 16990453 DOI: 10.1152/Physiol.00015.2006  0.597
2006 Lalioti MD, Zhang J, Volkman HM, Kahle KT, Hoffmann KE, Toka HR, Nelson-Williams C, Ellison DH, Flavell R, Booth CJ, Lu Y, Geller DS, Lifton RP. Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule. Nature Genetics. 38: 1124-32. PMID 16964266 DOI: 10.1038/Ng1877  0.658
2006 de Los Heros P, Kahle KT, Rinehart J, Bobadilla NA, Vázquez N, San Cristobal P, Mount DB, Lifton RP, Hebert SC, Gamba G. WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathway. Proceedings of the National Academy of Sciences of the United States of America. 103: 1976-81. PMID 16446421 DOI: 10.1073/Pnas.0510947103  0.628
2006 Leng Q, Kahle KT, Rinehart J, MacGregor GG, Wilson FH, Canessa CM, Lifton RP, Hebert SC. WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1). The Journal of Physiology. 571: 275-86. PMID 16357011 DOI: 10.1113/Jphysiol.2005.102202  0.785
2005 Rinehart J, Kahle KT, de Los Heros P, Vazquez N, Meade P, Wilson FH, Hebert SC, Gimenez I, Gamba G, Lifton RP. WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 102: 16777-82. PMID 16275913 DOI: 10.1073/Pnas.0508303102  0.784
2005 Kahle KT, Rinehart J, de Los Heros P, Louvi A, Meade P, Vazquez N, Hebert SC, Gamba G, Gimenez I, Lifton RP. WNK3 modulates transport of Cl- in and out of cells: implications for control of cell volume and neuronal excitability. Proceedings of the National Academy of Sciences of the United States of America. 102: 16783-8. PMID 16275911 DOI: 10.1073/Pnas.0508307102  0.602
2005 Kahle KT, Wilson FH, Lifton RP. Regulation of diverse ion transport pathways by WNK4 kinase: A novel molecular switch Trends in Endocrinology and Metabolism. 16: 98-103. PMID 15808806 DOI: 10.1016/J.Tem.2005.02.012  0.785
2004 Kahle KT, MacGregor GG, Wilson FH, Van Hoek AN, Brown D, Ardito T, Kashgarian M, Giebisch G, Hebert SC, Boulpaep EL, Lifton RP. Paracellular Cl- permeability is regulated by WNK4 kinase: Insight into normal physiology and hypertension Proceedings of the National Academy of Sciences of the United States of America. 101: 14877-14882. PMID 15465913 DOI: 10.1073/Pnas.0406172101  0.777
2004 Kahle KT, Wilson FH, Lalioti M, Toka H, Qin H, Lifton RP. WNK kinases: molecular regulators of integrated epithelial ion transport. Current Opinion in Nephrology and Hypertension. 13: 557-62. PMID 15300163 DOI: 10.1097/00041552-200409000-00012  0.76
2004 Kahle KT, Gimenez I, Hassan H, Wilson FH, Wong RD, Forbush B, Aronson PS, Lifton RP. WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia Proceedings of the National Academy of Sciences of the United States of America. 101: 2064-2069. PMID 14769928 DOI: 10.1073/Pnas.0308434100  0.78
2003 Kahle KT, Wilson FH, Leng Q, Lalioti MD, O'Connell AD, Dong K, Rapson AK, MacGregor GG, Giebisch G, Hebert SC, Lifton RP. WNK4 regulates the balance between renal NaCl reabsorption and K + secretion Nature Genetics. 35: 372-376. PMID 14608358 DOI: 10.1038/Ng1271  0.773
2003 Choate KA, Kahle KT, Wilson FH, Nelson-Williams C, Lifton RP. WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl--transporting epithelia Proceedings of the National Academy of Sciences of the United States of America. 100: 663-668. PMID 12522152 DOI: 10.1073/Pnas.242728499  0.803
2003 Wilson FH, Kahle KT, Sabath E, Lalioti MD, Rapson AK, Hoover RS, Hebert SC, Gamba G, Lifton RP. Molecular pathogenesis of inherited hypertension with hyperkalemia: The Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4 Proceedings of the National Academy of Sciences of the United States of America. 100: 680-684. PMID 12515852 DOI: 10.1073/Pnas.242735399  0.783
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