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Ali A. Zarrin, Ph.D. - Publications

Affiliations: 
2000 University of Toronto, Toronto, ON, Canada 
Area:
Immunology, Molecular Biology
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36 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Bao K, Zhang J, Scherl A, Ziai J, Hadadianpour A, Xu D, Dela Cruz C, Liu J, Liang Y, Tam L, Corzo CA, Roose-Girma M, Warming S, Modrusan Z, Lee WP, ... ... Zarrin AA, et al. Activation-Induced Cytidine Deaminase Impacts the Primary Antibody Repertoire in Naive Mice. Journal of Immunology (Baltimore, Md. : 1950). PMID 35675956 DOI: 10.4049/jimmunol.2101193  0.334
2020 Corzo CA, Varfolomeev E, Setiadi AF, Francis R, Klabunde S, Senger K, Sujatha-Bhaskar S, Drobnick J, Do S, Suto E, Huang Z, Eastham-Anderson J, Katewa A, Pang J, Domeyer M, ... ... Zarrin AA, et al. The kinase IRAK4 promotes endosomal TLR and immune complex signaling in B cells and plasmacytoid dendritic cells. Science Signaling. 13. PMID 32487715 DOI: 10.1126/Scisignal.Aaz1053  0.414
2020 Rajapaksa NS, Gobbi A, Drobnick J, Do S, Kolesnikov A, Liang J, Chen Y, Sujatha-Bhaskar S, Huang Z, Brightbill H, Francis R, Yu C, Choo EF, DeMent K, Ran Y, ... ... Zarrin AA, et al. Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity. Acs Medicinal Chemistry Letters. 11: 327-333. PMID 32184965 DOI: 10.1021/Acsmedchemlett.9B00380  0.308
2019 Easley-Neal C, Foreman O, Sharma N, Zarrin AA, Weimer RM. CSF1R Ligands IL-34 and CSF1 Are Differentially Required for Microglia Development and Maintenance in White and Gray Matter Brain Regions. Frontiers in Immunology. 10: 2199. PMID 31616414 DOI: 10.3389/Fimmu.2019.02199  0.306
2018 Rathore N, Ramani SR, Pantua H, Payandeh J, Bhangale T, Wuster A, Kapoor M, Sun Y, Kapadia SB, Gonzalez L, Zarrin AA, Goate A, Hansen DV, Behrens TW, Graham RR. Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease. Plos Genetics. 14: e1007427. PMID 30388101 DOI: 10.1371/Journal.Pgen.1007427  0.323
2017 Xu D, Matsumoto ML, McKenzie BS, Zarrin AA. TPL2 kinase action and control of inflammation. Pharmacological Research. PMID 29183769 DOI: 10.1016/J.Phrs.2017.11.031  0.304
2017 Senger K, Pham VC, Varfolomeev E, Hackney JA, Corzo CA, Collier J, Lau VWC, Huang Z, Hamidzhadeh K, Caplazi P, Peng I, Setiadi AF, Francis R, Paler-Martinez A, Kwon YC, ... ... Zarrin AA, et al. The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation. Science Signaling. 10. PMID 28420753 DOI: 10.1126/Scisignal.Aah4273  0.334
2015 Sun Y, Peng I, Webster JD, Suto E, Lesch J, Wu X, Senger K, Francis G, Barrett K, Collier JL, Burch JD, Zhou M, Chen Y, Chan C, Eastham-Anderson J, ... ... Zarrin AA, et al. Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response. Science Signaling. 8: ra122. PMID 26628680 DOI: 10.1126/Scisignal.Aab0949  0.331
2015 Senger K, Hackney J, Payandeh J, Zarrin AA. Antibody Isotype Switching in Vertebrates. Results and Problems in Cell Differentiation. 57: 295-324. PMID 26537387 DOI: 10.1007/978-3-319-20819-0_13  0.315
2015 Burch JD, Barrett K, Chen Y, DeVoss J, Eigenbrot C, Goldsmith R, Ismaili MH, Lau K, Lin Z, Ortwine DF, Zarrin AA, McEwan PA, Barker JJ, Ellebrandt C, Kordt D, et al. Tetrahydroindazoles as Interleukin-2 Inducible T-Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in Vivo. Journal of Medicinal Chemistry. 58: 3806-16. PMID 25844760 DOI: 10.1021/Jm501998M  0.358
2015 Lin W, Seshasayee D, Lee WP, Caplazi P, McVay S, Suto E, Nguyen A, Lin Z, Sun Y, DeForge L, Balazs M, Martin F, Zarrin AA. Dual B cell immunotherapy is superior to individual anti-CD20 depletion or BAFF blockade in murine models of spontaneous or accelerated lupus. Arthritis & Rheumatology (Hoboken, N.J.). 67: 215-24. PMID 25303150 DOI: 10.1002/Art.38907  0.364
2014 Trani G, Barker JJ, Bromidge SM, Brookfield FA, Burch JD, Chen Y, Eigenbrot C, Heifetz A, Ismaili MH, Johnson A, Krülle TM, MacKinnon CH, Maghames R, McEwan PA, Montalbetti CA, ... ... Zarrin AA, et al. Design, synthesis and structure-activity relationships of a novel class of sulfonylpyridine inhibitors of Interleukin-2 inducible T-cell kinase (ITK). Bioorganic & Medicinal Chemistry Letters. 24: 5818-23. PMID 25455497 DOI: 10.1016/J.Bmcl.2014.10.020  0.345
2014 Sun Y, Caplazi P, Zhang J, Mazloom A, Kummerfeld S, Quinones G, Senger K, Lesch J, Peng I, Sebrell A, Luk W, Lu Y, Lin Z, Barck K, Young J, ... ... Zarrin AA, et al. PILRα negatively regulates mouse inflammatory arthritis. Journal of Immunology (Baltimore, Md. : 1950). 193: 860-70. PMID 24935926 DOI: 10.4049/Jimmunol.1400045  0.32
2014 Burch JD, Lau K, Barker JJ, Brookfield F, Chen Y, Chen Y, Eigenbrot C, Ellebrandt C, Ismaili MH, Johnson A, Kordt D, MacKinnon CH, McEwan PA, Ortwine DF, Stein DB, ... ... Zarrin AA, et al. Property- and structure-guided discovery of a tetrahydroindazole series of interleukin-2 inducible T-cell kinase inhibitors. Journal of Medicinal Chemistry. 57: 5714-27. PMID 24918870 DOI: 10.1021/Jm500550E  0.321
2014 Wu LC, Zarrin AA. The production and regulation of IgE by the immune system. Nature Reviews. Immunology. 14: 247-59. PMID 24625841 DOI: 10.1038/Nri3632  0.302
2014 Gostissa M, Schwer B, Chang A, Dong J, Meyers RM, Marecki GT, Choi VW, Chiarle R, Zarrin AA, Alt FW. IgH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances. Proceedings of the National Academy of Sciences of the United States of America. 111: 2644-9. PMID 24550291 DOI: 10.1073/Pnas.1324176111  0.458
2013 Misaghi S, Senger K, Sai T, Qu Y, Sun Y, Hamidzadeh K, Nguyen A, Jin Z, Zhou M, Yan D, Lin WY, Lin Z, Lorenzo MN, Sebrell A, Ding J, ... ... Zarrin AA, et al. Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombination. Proceedings of the National Academy of Sciences of the United States of America. 110: 15770-5. PMID 24019479 DOI: 10.1073/Pnas.1221661110  0.424
2013 Kumar R, DiMenna L, Schrode N, Liu TC, Franck P, Muñoz-Descalzo S, Hadjantonakis AK, Zarrin AA, Chaudhuri J, Elemento O, Evans T. AID stabilizes stem-cell phenotype by removing epigenetic memory of pluripotency genes. Nature. 500: 89-92. PMID 23803762 DOI: 10.1038/Nature12299  0.389
2013 Sun Y, Peng I, Senger K, Hamidzadeh K, Reichelt M, Baca M, Yeh R, Lorenzo MN, Sebrell A, Dela Cruz C, Tam L, Corpuz R, Wu J, Sai T, Roose-Girma M, ... ... Zarrin AA, et al. Critical role of activation induced cytidine deaminase in experimental autoimmune encephalomyelitis. Autoimmunity. 46: 157-67. PMID 23167594 DOI: 10.3109/08916934.2012.750301  0.378
2012 Zhu C, Lee V, Finn A, Senger K, Zarrin AA, Du Pasquier L, Hsu E. Origin of immunoglobulin isotype switching. Current Biology : Cb. 22: 872-80. PMID 22542103 DOI: 10.1016/J.Cub.2012.03.060  0.406
2010 Perlot T, Pawlitzky I, Manis JP, Zarrin AA, Brodeur PH, Alt FW. Analysis of mice lacking DNaseI hypersensitive sites at the 5' end of the IgH locus. Plos One. 5: e13992. PMID 21085586 DOI: 10.1371/Journal.Pone.0013992  0.404
2010 Misaghi S, Garris CS, Sun Y, Nguyen A, Zhang J, Sebrell A, Senger K, Yan D, Lorenzo MN, Heldens S, Lee WP, Xu M, Wu J, DeForge L, Sai T, ... ... Zarrin AA, et al. Increased targeting of donor switch region and IgE in Sγ1-deficient B cells Journal of Immunology. 185: 166-173. PMID 20511552 DOI: 10.4049/Jimmunol.1000515  0.483
2009 Lee YN, Alt FW, Reyes J, Gleason M, Zarrin AA, Jung D. Differential utilization of T cell receptor TCR alpha/TCR delta locus variable region gene segments is mediated by accessibility. Proceedings of the National Academy of Sciences of the United States of America. 106: 17487-92. PMID 19805067 DOI: 10.1073/Pnas.0909723106  0.366
2009 Wang JH, Gostissa M, Yan CT, Goff P, Hickernell T, Hansen E, Difilippantonio S, Wesemann DR, Zarrin AA, Rajewsky K, Nussenzweig A, Alt FW. Mechanisms promoting translocations in editing and switching peripheral B cells. Nature. 460: 231-6. PMID 19587764 DOI: 10.1038/Nature08159  0.435
2009 Hackney JA, Misaghi S, Senger K, Garris C, Sun Y, Lorenzo MN, Zarrin AA. DNA targets of AID evolutionary link between antibody somatic hypermutation and class switch recombination. Advances in Immunology. 101: 163-89. PMID 19231595 DOI: 10.1016/S0065-2776(08)01005-5  0.411
2008 Zarrin AA, Goff PH, Senger K, Alt FW. Sgamma3 switch sequences function in place of endogenous Sgamma1 to mediate antibody class switching. The Journal of Experimental Medicine. 205: 1567-72. PMID 18541713 DOI: 10.1084/Jem.20080451  0.457
2007 Yan CT, Boboila C, Souza EK, Franco S, Hickernell TR, Murphy M, Gumaste S, Geyer M, Zarrin AA, Manis JP, Rajewsky K, Alt FW. IgH class switching and translocations use a robust non-classical end-joining pathway. Nature. 449: 478-82. PMID 17713479 DOI: 10.1038/Nature06020  0.402
2007 Chaudhuri J, Basu U, Zarrin A, Yan C, Franco S, Perlot T, Vuong B, Wang J, Phan RT, Datta A, Manis J, Alt FW. Evolution of the immunoglobulin heavy chain class switch recombination mechanism. Advances in Immunology. 94: 157-214. PMID 17560275 DOI: 10.1016/S0065-2776(06)94006-1  0.459
2007 Zarrin AA, Del Vecchio C, Tseng E, Gleason M, Zarin P, Tian M, Alt FW. Antibody class switching mediated by yeast endonuclease-generated DNA breaks. Science (New York, N.Y.). 315: 377-81. PMID 17170253 DOI: 10.1126/Science.1136386  0.448
2006 Franco S, Gostissa M, Zha S, Lombard DB, Murphy MM, Zarrin AA, Yan C, Tepsuporn S, Morales JC, Adams MM, Lou Z, Bassing CH, Manis JP, Chen J, Carpenter PB, et al. H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Molecular Cell. 21: 201-14. PMID 16427010 DOI: 10.1016/J.Molcel.2006.01.005  0.377
2005 Zarrin AA, Tian M, Wang J, Borjeson T, Alt FW. Influence of switch region length on immunoglobulin class switch recombination. Proceedings of the National Academy of Sciences of the United States of America. 102: 2466-70. PMID 15684074 DOI: 10.1073/Pnas.0409847102  0.391
2004 Zarrin AA, Alt FW, Chaudhuri J, Stokes N, Kaushal D, Du Pasquier L, Tian M. An evolutionarily conserved target motif for immunoglobulin class-switch recombination. Nature Immunology. 5: 1275-81. PMID 15531884 DOI: 10.1038/Ni1137  0.395
2002 Dudley DD, Manis JP, Zarrin AA, Kaylor L, Tian M, Alt FW. Internal IgH class switch region deletions are position-independent and enhanced by AID expression. Proceedings of the National Academy of Sciences of the United States of America. 99: 9984-9. PMID 12114543 DOI: 10.1073/Pnas.152333499  0.48
2000 Fong IC, Zarrin AA, Wu GE, Berinstein NL. Functional analysis of the human RAG 2 promoter. Molecular Immunology. 37: 391-402. PMID 11074256 DOI: 10.1016/S0161-5890(00)00056-0  0.625
1999 Zarrin AA, Malkin L, Fong I, Luk KD, Ghose A, Berinstein NL. Comparison of CMV, RSV, SV40 viral and Vlambda1 cellular promoters in B and T lymphoid and non-lymphoid cell lines. Biochimica Et Biophysica Acta. 1446: 135-9. PMID 10395926 DOI: 10.1016/S0167-4781(99)00067-6  0.595
1997 Zarrin AA, Fong I, Malkin L, Marsden PA, Berinstein NL. Cloning and characterization of the human recombination activating gene 1 (RAG1) and RAG2 promoter regions. Journal of Immunology (Baltimore, Md. : 1950). 159: 4382-94. PMID 9379036  0.6
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