George J. Murphy - Publications

Affiliations: 
Molecular Medicine Boston University, Boston, MA, United States 
Area:
Molecular Biology

57 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Dowrey TW, Cranston SF, Skvir N, Lok Y, Gould B, Petrowitz B, Villar D, Shan J, James M, Dodge M, Belkina AC, Giadone RM, Sebastiani P, Perls TT, Andersen SL, ... Murphy GJ, et al. A longevity-specific bank of induced pluripotent stem cells from centenarians and their offspring. Biorxiv : the Preprint Server For Biology. PMID 38559230 DOI: 10.1101/2024.03.12.584663  0.421
2023 Hoffman SE, Dowrey TW, Villacorta Martin C, Bi K, Titchen B, Johri S, DelloStritto L, Patel M, Mackichan C, Inga S, Chen J, Grimaldi G, Napolitano S, Wakiro I, Wu J, ... ... Murphy GJ, et al. Intertumoral lineage diversity and immunosuppressive transcriptional programs in well-differentiated gastroenteropancreatic neuroendocrine tumors. Science Advances. 9: eadd9668. PMID 37756410 DOI: 10.1126/sciadv.add9668  0.319
2023 Yeung AK, Villacorta-Martin C, Lindstrom-Vautrin J, Belkina AC, Vanuytsel K, Dowrey TW, Ysasi AB, Bawa P, Wang F, Vrbanac V, Mostoslavsky G, Balazs A, Murphy GJ. De-novo hematopoiesis from the fetal lung. Blood Advances. PMID 37729429 DOI: 10.1182/bloodadvances.2022008347  0.348
2022 Heinze D, Park S, McCracken A, Haratianfar M, Lindstrom J, Villacorta-Martin C, Mithal A, Wang F, Yang MW, Murphy G, Mostoslavsky G. Notch activation during early mesoderm induction modulates emergence of the T/NK cell lineage from human iPSCs. Stem Cell Reports. PMID 36332629 DOI: 10.1016/j.stemcr.2022.10.007  0.477
2022 Vanuytsel K, Yeung AK, Dowrey TW, Murphy GJ, Belkina AC. Comprehensive phenotyping of hematopoietic stem and progenitor cells in the human fetal liver. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. PMID 35253987 DOI: 10.1002/cyto.a.24540  0.547
2022 Vanuytsel K, Villacorta-Martin C, Lindstrom-Vautrin J, Wang Z, Garcia-Beltran WF, Vrbanac V, Parsons D, Lam EC, Matte TM, Dowrey TW, Kumar SS, Li M, Wang F, Yeung AK, Mostoslavsky G, ... ... Murphy GJ, et al. Multi-modal profiling of human fetal liver hematopoietic stem cells reveals the molecular signature of engraftment. Nature Communications. 13: 1103. PMID 35232959 DOI: 10.1038/s41467-022-28616-x  0.544
2022 Sun Y, Habara A, Le CQ, Nguyen N, Chen R, Murphy GJ, Chui DHK, Steinberg MH, Cui S. Pharmacologic induction of PGC-1α stimulates fetal haemoglobin gene expression. British Journal of Haematology. PMID 35118652 DOI: 10.1111/bjh.18042  0.411
2021 Blakemore D, Vilaplana-Lopera N, Almaghrabi R, Gonzalez E, Moya M, Ward C, Murphy G, Gambus A, Petermann E, Stewart GS, García P. MYBL2 and ATM suppress replication stress in pluripotent stem cells. Embo Reports. e51120. PMID 33779025 DOI: 10.15252/embr.202051120  0.307
2020 Giadone RM, Liberti DC, Matte TM, Rosarda JD, Torres-Arancivia C, Ghosh S, Diedrich JK, Pankow S, Skvir N, Jean JC, Yates JR, Wilson AA, Connors LH, Kotton DN, Wiseman RL, ... Murphy GJ, et al. Expression of Amyloidogenic Transthyretin Drives Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease. Stem Cell Reports. PMID 32735824 DOI: 10.1016/J.Stemcr.2020.07.003  0.541
2020 Kanchan K, Iyer K, Yanek LR, Carcamo-Orive I, Taub MA, Malley C, Baldwin K, Becker LC, Broeckel U, Cheng L, Cowan C, D'Antonio M, Frazer KA, Quertermous T, Mostoslavsky G, ... Murphy G, et al. Genomic integrity of human induced pluripotent stem cells across nine studies in the NHLBI NextGen program. Stem Cell Research. 46: 101803. PMID 32442913 DOI: 10.1016/J.Scr.2020.101803  0.315
2019 Steinberg MH, Kumar S, Murphy GJ, Vanuytsel K. Sickle cell disease in the era of precision medicine: looking to the future. Expert Review of Precision Medicine and Drug Development. 4: 357-367. PMID 33015364 DOI: 10.1080/23808993.2019.1688658  0.432
2019 Le CQ, Myers G, Habara A, Jearawiriyapaisarn N, Murphy GJ, Chui DHK, Steinberg M, Engel JD, Cui S. Inhibition of LSD1 by small molecule inhibitors stimulates fetal hemoglobin synthesis. Blood. PMID 30992270 DOI: 10.1182/Blood.2018892737  0.391
2019 Athwal HK, Murphy G, Tibbs E, Cornett A, Hill E, Yeoh K, Berenstein E, Hoffman MP, Lombaert IMA. Sox10 Regulates Plasticity of Epithelial Progenitors toward Secretory Units of Exocrine Glands. Stem Cell Reports. PMID 30713042 DOI: 10.1016/j.stemcr.2019.01.002  0.405
2019 Vanuytsel K, Villacorta-Martin C, Garcia Beltran W, Matte T, Balazs A, Murphy GJ. Transcriptional, Protein-Level and Functional Profiling of Human Fetal Liver-Derived Hematopoietic Stem Cells at Single Cell Resolution Blood. 134: 1187-1187. DOI: 10.1182/Blood-2019-126857  0.501
2018 Seo H, Chen SJ, Hashimoto K, Endo H, Nishi Y, Ohta A, Yamamoto T, Hotta A, Sawaguchi A, Hayashi H, Koseki N, Murphy GJ, Fukuda K, Sugimoto N, Eto K. A β1-tubulin-based megakaryocyte maturation reporter system identifies novel drugs that promote platelet production. Blood Advances. 2: 2262-2272. PMID 30206099 DOI: 10.1182/Bloodadvances.2018019547  0.373
2018 Vanuytsel K, Matte T, Leung A, Naing ZH, Morrison T, Chui DHK, Steinberg MH, Murphy GJ. Induced pluripotent stem cell-based mapping of β-globin expression throughout human erythropoietic development. Blood Advances. 2: 1998-2011. PMID 30108108 DOI: 10.1182/Bloodadvances.2018020560  0.592
2018 Giadone RM, Rosarda JD, Akepati PR, Thomas AC, Boldbaatar B, James MF, Wilson AA, Sanchorawala V, Connors LH, Berk JL, Wiseman RL, Murphy GJ. A library of ATTR amyloidosis patient-specific induced pluripotent stem cells for disease modelling and in vitro testing of novel therapeutics. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 1-8. PMID 30032658 DOI: 10.1080/13506129.2018.1489228  0.538
2018 Leung A, Zulick E, Skvir N, Vanuytsel K, Morrison TA, Naing ZH, Wang Z, Dai Y, Chui DHK, Steinberg MH, Sherr DH, Murphy GJ. Notch and AHR signaling impact definitive hematopoiesis from human pluripotent stem cells. Stem Cells (Dayton, Ohio). PMID 29569827 DOI: 10.1002/Stem.2822  0.659
2018 Habara A, Le C, Murphy GJ, Chui DHK, Steinberg MH, Cui S. Regulating Transcriptional Co-Activator PGC-1α for the Treatment of Sickle Cell Disease Blood. 132: 2358-2358. DOI: 10.1182/Blood-2018-99-111022  0.403
2017 Morrison TA, Wilcox I, Luo HY, Farrell JJ, Kurita R, Nakamura Y, Murphy GJ, Cui S, Steinberg MH, Chui DHK. A long noncoding RNA from the HBS1L-MYB intergenic region on chr6q23 regulates human fetal hemoglobin expression. Blood Cells, Molecules & Diseases. 69: 1-9. PMID 29227829 DOI: 10.1016/j.bcmd.2017.11.003  0.436
2017 Shaikho EM, Farrell JJ, Alsultan A, Qutub H, Al-Ali AK, Figueiredo MS, Chui DHK, Farrer LA, Murphy GJ, Mostoslavsky G, Sebastiani P, Steinberg MH. A phased SNP-based classification of sickle cell anemia HBB haplotypes. Bmc Genomics. 18: 608. PMID 28800727 DOI: 10.1186/S12864-017-4013-Y  0.351
2017 Park S, Gianotti-Sommer A, Molina-Estevez FJ, Vanuytsel K, Skvir N, Leung A, Rozelle SS, Shaikho EM, Weir I, Jiang Z, Luo HY, Chui DH, Figueiredo MS, Alsultan A, Al-Ali A, ... ... Murphy GJ, et al. A Comprehensive, Ethnically Diverse Library of Sickle Cell Disease-Specific Induced Pluripotent Stem Cells. Stem Cell Reports. PMID 28111279 DOI: 10.1016/J.Stemcr.2016.12.017  0.76
2016 Vathipadiekal V, Farrell JJ, Wang S, Edward HL, Shappell H, Al-Rubaish AM, Al-Muhanna F, Naserullah Z, Alsuliman A, Qutub HO, Simkin I, Farrer LA, Jiang Z, Luo HY, Huang S, ... ... Murphy G, et al. A Candidate Trans-acting Modulator of Fetal Hemoglobin Gene Expression in the Arab-Indian Haplotype of Sickle Cell Anemia: -ANTXR1 Variants and HbF. American Journal of Hematology. PMID 27501013 DOI: 10.1002/Ajh.24527  0.519
2016 Smith BW, Stanford EA, Sherr DH, Murphy GJ. Genome Editing of the CYP1A1 Locus in iPSCs as a Platform to Map AHR Expression throughout Human Development. Stem Cells International. 2016: 2574152. PMID 27148368 DOI: 10.1155/2016/2574152  0.495
2016 Tirosh I, Izar B, Prakadan SM, Wadsworth MH, Treacy D, Trombetta JJ, Rotem A, Rodman C, Lian C, Murphy G, Fallahi-Sichani M, Dutton-Regester K, Lin JR, Cohen O, Shah P, et al. Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq. Science (New York, N.Y.). 352: 189-196. PMID 27124452 DOI: 10.1126/Science.Aad0501  0.392
2016 Stanford EA, Wang Z, Novikov O, Mulas F, Landesman-Bollag E, Monti S, Smith BW, Seldin DC, Murphy GJ, Sherr DH. The role of the aryl hydrocarbon receptor in the development of cells with the molecular and functional characteristics of cancer stem-like cells. Bmc Biology. 14: 20. PMID 26984638 DOI: 10.1186/S12915-016-0240-Y  0.524
2016 Thomas DD, Sommer AG, Balazs AB, Beerman I, Murphy GJ, Rossi D, Mostoslavsky G. Insulin-like growth factor 2 (IGF2) modulates murine hematopoietic stem cell maintenance through upregulation of p57. Experimental Hematology. PMID 26872540 DOI: 10.1016/J.Exphem.2016.01.010  0.468
2016 Stanford E, Wang Z, Novikov O, Ramirez-Cardenas A, Mulas F, Landesman-Bollag E, Monti S, Smith B, Bais M, Kukuruzinska M, Murphy G, Sherr D. A role for the aryl hydrocarbon receptor (Ahr) in the production and function of breast and oral cancer stem-like cells and the potential therapeutic value of Ahr modulators Toxicology Letters. 259: S20. DOI: 10.1016/j.toxlet.2016.07.090  0.322
2015 Wilson AA, Ying L, Liesa M, Segeritz CP, Mills JA, Shen SS, Jean J, Lonza GC, Liberti DC, Lang AH, Nazaire J, Gower AC, Müeller FJ, Mehta P, Ordóñez A, ... ... Murphy GJ, et al. Emergence of a stage-dependent human liver disease signature with directed differentiation of alpha-1 antitrypsin-deficient iPS cells. Stem Cell Reports. 4: 873-85. PMID 25843048 DOI: 10.1016/J.Stemcr.2015.02.021  0.566
2015 Leung A, Murphy GJ. Multisystemic Disease Modeling of Liver-Derived Protein Folding Disorders Using Induced Pluripotent Stem Cells (iPSCs). Methods in Molecular Biology (Clifton, N.J.). PMID 25646614 DOI: 10.1007/7651_2014_194  0.447
2015 Vathipadiekal V, Farrell J, Shuai Z, Edward H, Shappell H, Al-Rubaish AM, Al-Muhanna F, Naserullah Z, Alsuliman A, Simkin I, Farrer L, Jiang Z, Luo HY, Huang S, Mostoslavsky G, ... Murphy GJ, et al. A Candidate Trans-Acting Modulator of Fetal Hemoglobin Gene Expression in the Arab-Indian Haplotype of Sickle Cell Anemia Blood. 126: 409-409. DOI: 10.1182/Blood.V126.23.409.409  0.355
2015 Park S, Gianotti-Sommer A, Chui DHK, Figueiredo MS, Alsultan A, Al-Ali A, Steinberg MH, Murphy GJ, Mostoslavsky G. A Library of Sickle Cell Anemia Induced Pluripotent Stem Cells of Diverse Haplotypes and Ethnicities Blood. 126: 2354-2354. DOI: 10.1182/Blood.V126.23.2354.2354  0.638
2014 Smith BW, Murphy GJ. Stem cells, megakaryocytes, and platelets. Current Opinion in Hematology. 21: 430-7. PMID 25023469 DOI: 10.1097/Moh.0000000000000064  0.491
2014 Wang LB, Sommer AG, Leung A, Park S, Chui DHK, Steinberg MH, Mostoslavsky G, Murphy GJ. Multisystem, Induced Pluripotent Stem Cell (iPSC) Modeling Reveals a Role for Growth Differentiation Factors (GDFs) in the Etiology of β Thalassemia and Ineffective Erythropoiesis Blood. 124: 4039-4039. DOI: 10.1182/Blood.V124.21.4039.4039  0.486
2013 Leung A, Nah SK, Reid W, Ebata A, Koch CM, Monti S, Genereux JC, Wiseman RL, Wolozin B, Connors LH, Berk JL, Seldin DC, Mostoslavsky G, Kotton DN, Murphy GJ. Induced pluripotent stem cell modeling of multisystemic, hereditary transthyretin amyloidosis. Stem Cell Reports. 1: 451-63. PMID 24286032 DOI: 10.1016/J.Stemcr.2013.10.003  0.506
2013 Smith BW, Rozelle SS, Leung A, Ubellacker J, Parks A, Nah SK, French D, Gadue P, Monti S, Chui DH, Steinberg MH, Frelinger AL, Michelson AD, Theberge R, McComb ME, ... ... Murphy GJ, et al. The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation. Blood. 122: 376-85. PMID 23723449 DOI: 10.1182/Blood-2012-11-466722  0.78
2012 Sommer AG, Rozelle SS, Sullivan S, Mills JA, Park SM, Smith BW, Iyer AM, French DL, Kotton DN, Gadue P, Murphy GJ, Mostoslavsky G. Generation of human induced pluripotent stem cells from peripheral blood using the STEMCCA lentiviral vector. Journal of Visualized Experiments : Jove. PMID 23149977 DOI: 10.3791/4327  0.769
2012 Smith BW, Rozelle SS, Gadue P, French DL, Chui DHK, Steinberg MH, Sherr DH, Murphy GJ. The Aryl Hydrocarbon Receptor (AhR) Regulates the Production of Bipotential Hematopoietic Progenitor Cells Blood. 120: 766-766. DOI: 10.1182/Blood.V120.21.766.766  0.777
2012 Rozelle SS, Smith BW, Melista E, Aneni E, Sebastiani P, Baldwin CT, Alsultan A, Chui DHK, Mostoslavsky G, Steinberg MH, Murphy GJ. Induced Pluripotent Stem Cell Modeling of Sickle Cell Anemia Blood. 120: 3233-3233. DOI: 10.1182/Blood.V120.21.3233.3233  0.783
2011 Christodoulou C, Longmire TA, Shen SS, Bourdon A, Sommer CA, Gadue P, Spira A, Gouon-Evans V, Murphy GJ, Mostoslavsky G, Kotton DN. Mouse ES and iPS cells can form similar definitive endoderm despite differences in imprinted genes. The Journal of Clinical Investigation. 121: 2313-25. PMID 21537085 DOI: 10.1172/Jci43853  0.646
2011 Purwar R, Campbell J, Murphy G, Richards WG, Clark RA, Kupper TS. Resident memory T cells (T(RM)) are abundant in human lung: diversity, function, and antigen specificity. Plos One. 6: e16245. PMID 21298112 DOI: 10.1371/Journal.Pone.0016245  0.335
2011 Smith BW, Kotton DN, Mostoslavsky G, Murphy GJ. Pluripotent Stem Cell Modeling of Normal and Abnormal Megakaryocyte Development and Platelet Production Blood. 118: 1276-1276. DOI: 10.1182/Blood.V118.21.1276.1276  0.567
2010 Somers A, Jean JC, Sommer CA, Omari A, Ford CC, Mills JA, Ying L, Sommer AG, Jean JM, Smith BW, Lafyatis R, Demierre MF, Weiss DJ, French DL, Gadue P, ... Murphy GJ, et al. Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette. Stem Cells (Dayton, Ohio). 28: 1728-40. PMID 20715179 DOI: 10.1002/Stem.495  0.595
2010 Wilson AA, Murphy GJ, Hamakawa H, Kwok LW, Srinivasan S, Hovav AH, Mulligan RC, Amar S, Suki B, Kotton DN. Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages. The Journal of Clinical Investigation. 120: 379-89. PMID 20038801 DOI: 10.1172/Jci36666  0.466
2010 Sommer CA, Sommer AG, Longmire TA, Christodoulou C, Thomas DD, Gostissa M, Alt FW, Murphy GJ, Kotton DN, Mostoslavsky G. Excision of reprogramming transgenes improves the differentiation potential of iPS cells generated with a single excisable vector. Stem Cells (Dayton, Ohio). 28: 64-74. PMID 19904830 DOI: 10.1002/Stem.255  0.607
2009 Sommer CA, Stadtfeld M, Murphy GJ, Hochedlinger K, Kotton DN, Mostoslavsky G. Induced pluripotent stem cell generation using a single lentiviral stem cell cassette. Stem Cells (Dayton, Ohio). 27: 543-9. PMID 19096035 DOI: 10.1634/Stemcells.2008-1075  0.642
2007 Alison MR, Murphy G, Leedham S. Stem cells and cancer: a deadly mix. Cell and Tissue Research. 331: 109-24. PMID 17938965 DOI: 10.1007/s00441-007-0510-7  0.495
2006 Murphy GJ, Mostoslavsky G, Kotton DN, Mulligan RC. Exogenous control of mammalian gene expression via modulation of translational termination. Nature Medicine. 12: 1093-9. PMID 16892063 DOI: 10.1038/Nm1376  0.404
2004 Gaur M, Murphy GJ, Frampton J, Leavitt AD. Using retroviruses to express genes in primary megakaryocyte lineage cells. Methods in Molecular Biology (Clifton, N.J.). 273: 381-96. PMID 15308813 DOI: 10.1385/1-59259-783-1:381  0.478
2004 Emambokus NR, Murphy GJ, Frampton J. Manipulation of gene expression in megakaryocytes. Methods in Molecular Biology (Clifton, N.J.). 273: 33-56. PMID 15308792 DOI: 10.1385/1-59259-783-1:033  0.506
2004 Göttgens B, Broccardo C, Sanchez MJ, Deveaux S, Murphy G, Göthert JR, Kotsopoulou E, Kinston S, Delaney L, Piltz S, Barton LM, Knezevic K, Erber WN, Begley CG, Frampton J, et al. The scl +18/19 stem cell enhancer is not required for hematopoiesis: identification of a 5' bifunctional hematopoietic-endothelial enhancer bound by Fli-1 and Elf-1. Molecular and Cellular Biology. 24: 1870-83. PMID 14966269 DOI: 10.1128/MCB.24.5.1870-1883.2004  0.461
2004 Petrovic A, Alpdogan O, Willis LM, Eng JM, Greenberg AS, Kappel BJ, Liu C, Murphy GJ, Heller G, van den Brink MR. LPAM (alpha 4 beta 7 integrin) is an important homing integrin on alloreactive T cells in the development of intestinal graft-versus-host disease. Blood. 103: 1542-7. PMID 14563643 DOI: 10.1182/Blood-2003-03-0957  0.322
2003 Murphy GJ, Göttgens B, Vegiopoulos A, Sanchez MJ, Leavitt AD, Watson SP, Green AR, Frampton J. Manipulation of mouse hematopoietic progenitors by specific retroviral infection. The Journal of Biological Chemistry. 278: 43556-63. PMID 12928443 DOI: 10.1074/Jbc.M302717200  0.592
2001 Gaur M, Murphy GJ, deSauvage FJ, Leavitt AD. Characterization of Mpl mutants using primary megakaryocyte-lineage cells from mpl(-/-) mice: a new system for Mpl structure-function studies. Blood. 97: 1653-61. PMID 11238104 DOI: 10.1182/Blood.V97.6.1653  0.534
2000 Berlanga O, Bobe R, Becker M, Murphy G, Leduc M, Bon C, Barry FA, Gibbins JM, Garcia P, Frampton J, Watson SP. Expression of the collagen receptor glycoprotein VI during megakaryocyte differentiation. Blood. 96: 2740-2745. DOI: 10.1182/Blood.V96.8.2740.H8002740_2740_2745  0.451
1999 Shiraga M, Ritchie A, Aidoudi S, Baron V, Wilcox D, White G, Ybarrondo B, Murphy G, Leavitt A, Shattil S. Primary Megakaryocytes Reveal a Role for Transcription Factor Nf-E2 in Integrin αiibβ3 Signaling Journal of Cell Biology. 147: 1419-1430. PMID 10613901 DOI: 10.1083/Jcb.147.7.1419  0.361
1999 Murphy GJ, Leavitt AD. A model for studying megakaryocyte development and biology. Proceedings of the National Academy of Sciences of the United States of America. 96: 3065-70. PMID 10077637 DOI: 10.1073/Pnas.96.6.3065  0.492
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