| Year |
Citation |
Score |
| 2024 |
Lana-Elola E, Aoidi R, Llorian M, Gibbins D, Buechsenschuetz C, Bussi C, Flynn H, Gilmore T, Watson-Scales S, Haugsten Hansen M, Hayward D, Song OR, Brault V, Herault Y, Deau E, ... ... Tybulewicz VLJ, et al. Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome. Science Translational Medicine. 16: eadd6883. PMID 38266108 DOI: 10.1126/scitranslmed.add6883 |
0.314 |
|
| 2023 |
Redhead Y, Gibbins D, Lana-Elola E, Watson-Scales S, Dobson L, Krause M, Liu KJ, Fisher EMC, Green JBA, Tybulewicz VLJ. Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes. Development (Cambridge, England). 150. PMID 37102702 DOI: 10.1242/dev.201077 |
0.764 |
|
| 2023 |
Sloan K, Thomas J, Blackwell M, Voisard D, Lana-Elola E, Watson-Scales S, Roper DL, Wallace JM, Fisher EMC, Tybulewicz VLJ, Roper RJ. Genetic dissection of triplicated Hsa21 orthologs produces differential skeletal phenotypes in Down syndrome mouse models. Disease Models & Mechanisms. PMID 36939025 DOI: 10.1242/dmm.049927 |
0.341 |
|
| 2023 |
Muza PM, Bush D, Pérez-González M, Zouhair I, Cleverley K, Sopena ML, Aoidi R, West SJ, Good M, Tybulewicz VLJ, Walker MC, Fisher EMC, Chang P. Cognitive impairments in a Down syndrome model with abnormal hippocampal and prefrontal dynamics and cytoarchitecture. Iscience. 26: 106073. PMID 36818290 DOI: 10.1016/j.isci.2023.106073 |
0.342 |
|
| 2022 |
Mumford P, Tosh J, Anderle S, Wikberg EG, Lau G, Noy S, Cleverley K, Saito T, Saido TC, Yu E, Brinkmalm G, Portelius E, Blennow K, Zetterberg H, Tybulewicz V, et al. Genetic mapping of APP and amyloid-β biology modulation by trisomy 21. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 35835549 DOI: 10.1523/JNEUROSCI.0521-22.2022 |
0.309 |
|
| 2021 |
Tosh J, Tybulewicz V, Fisher EMC. Mouse models of aneuploidy to understand chromosome disorders. Mammalian Genome : Official Journal of the International Mammalian Genome Society. PMID 34719726 DOI: 10.1007/s00335-021-09930-z |
0.406 |
|
| 2021 |
Lana-Elola E, Cater H, Watson-Scales S, Greenaway S, Müller-Winkler J, Gibbins D, Nemes M, Slender A, Hough T, Keskivali-Bond P, Scudamore CL, Herbert E, Banks GT, Mobbs H, Canonica T, ... ... Tybulewicz VLJ, et al. Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of down syndrome-related phenotypes. Disease Models & Mechanisms. PMID 34477842 DOI: 10.1242/dmm.049157 |
0.39 |
|
| 2021 |
Toussaint N, Redhead Y, Vidal-García M, Lo Vercio L, Liu W, Fisher EMC, Hallgrímsson B, Tybulewicz VLJ, Schnabel JA, Green JBA. A landmark-free morphometrics pipeline for high-resolution phenotyping: application to a mouse model of Down syndrome. Development (Cambridge, England). 148. PMID 34308975 DOI: 10.1242/dev.188631 |
0.58 |
|
| 2021 |
Toussaint N, Redhead Y, Vidal-García M, Lo Vercio L, Liu W, Fisher EMC, Hallgrímsson B, Tybulewicz VLJ, Schnabel JA, Green JBA. A landmark-free morphometrics pipeline for high-resolution phenotyping: application to a mouse model of Down syndrome. Development (Cambridge, England). 148. PMID 33712441 DOI: 10.1242/dev.188631 |
0.743 |
|
| 2021 |
Tosh JL, Rhymes ER, Mumford P, Whittaker HT, Pulford LJ, Noy SJ, Cleverley K, Walker MC, Tybulewicz VLJ, Wykes RC, Fisher EMC, Wiseman FK. Genetic dissection of down syndrome-associated alterations in APP/amyloid-β biology using mouse models. Scientific Reports. 11: 5736. PMID 33707583 DOI: 10.1038/s41598-021-85062-3 |
0.312 |
|
| 2020 |
Lana-Elola E, Watson-Scales S, Slender A, Gibbins D, Martineau A, Douglas C, Mohun T, Fisher EM, Tybulewicz VL. Correction: Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel. Elife. 9. PMID 32692312 DOI: 10.7554/eLife.61021 |
0.508 |
|
| 2020 |
Chang P, Bush D, Schorge S, Good M, Canonica T, Shing N, Noy S, Wiseman FK, Burgess N, Tybulewicz VLJ, Walker MC, Fisher EMC. Altered Hippocampal-Prefrontal Neural Dynamics in Mouse Models of Down Syndrome. Cell Reports. 30: 1152-1163.e4. PMID 31995755 DOI: 10.1016/J.Celrep.2019.12.065 |
0.304 |
|
| 2019 |
Ahlfors H, Anyanwu N, Pakanavicius E, Dinischiotu N, Lana-Elola E, Watson-Scales S, Tosh J, Wiseman F, Briscoe J, Page K, Fisher EMC, Tybulewicz VLJ. Gene expression dysregulation domains are not a specific feature of Down syndrome. Nature Communications. 10: 2489. PMID 31171815 DOI: 10.1038/S41467-019-10129-9 |
0.342 |
|
| 2018 |
Watson-Scales S, Kalmar B, Lana-Elola E, Gibbins D, La Russa F, Wiseman F, Williamson M, Saccon R, Slender A, Olerinyova A, Mahmood R, Nye E, Cater H, Wells S, Yu YE, ... ... Tybulewicz VLJ, et al. Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration. Plos Genetics. 14: e1007383. PMID 29746474 DOI: 10.1371/Journal.Pgen.1007383 |
0.32 |
|
| 2017 |
Naert G, Ferré V, Keller E, Slender A, Gibbins D, Fisher EM, Tybulewicz VL, Maurice T. In vivo and ex vivo analyses of amyloid toxicity in the Tc1 mouse model of Down syndrome. Journal of Psychopharmacology (Oxford, England). 269881117743484. PMID 29215943 DOI: 10.1177/0269881117743484 |
0.544 |
|
| 2017 |
Herault Y, Delabar JM, Fisher EMC, Tybulewicz VLJ, Yu E, Brault V. Rodent models in Down syndrome research: impact and future opportunities. Disease Models & Mechanisms. 10: 1165-1186. PMID 28993310 DOI: 10.1242/Dmm.029728 |
0.339 |
|
| 2016 |
Qiu J, McQueen J, Bilican B, Dando O, Magnani D, Punovuori K, Selvaraj BT, Livesey M, Haghi G, Heron S, Burr K, Patani R, Rajan R, Sheppard O, Kind PC, ... ... Tybulewicz VL, et al. Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons. Elife. 5. PMID 27692071 DOI: 10.7554/Elife.20337 |
0.552 |
|
| 2016 |
Powell NM, Modat M, Cardoso MJ, Ma D, Holmes HE, Yu Y, O'Callaghan J, Cleary JO, Sinclair B, Wiseman FK, Tybulewicz VL, Fisher EM, Lythgoe MF, Ourselin S. Fully-Automated μMRI Morphometric Phenotyping of the Tc1 Mouse Model of Down Syndrome. Plos One. 11: e0162974. PMID 27658297 DOI: 10.1371/Journal.Pone.0162974 |
0.563 |
|
| 2016 |
Peiris H, Duffield MD, Fadista J, Jessup CF, Kashmir V, Genders AJ, McGee SL, Martin AM, Saiedi M, Morton N, Carter R, Cousin MA, Kokotos AC, Oskolkov N, Volkov P, ... ... Tybulewicz VL, et al. A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes. Plos Genetics. 12: e1006033. PMID 27195491 DOI: 10.1371/Journal.Pgen.1006033 |
0.503 |
|
| 2016 |
Karmiloff-Smith A, Al-Janabi T, D'Souza H, Groet J, Massand E, Mok K, Startin C, Fisher E, Hardy J, Nizetic D, Tybulewicz V, Strydom A. The importance of understanding individual differences in Down syndrome. F1000research. 5. PMID 27019699 DOI: 10.12688/F1000Research.7506.1 |
0.623 |
|
| 2016 |
Hall JH, Wiseman FK, Fisher EM, Tybulewicz VL, Harwood JL, Good MA. Tc1 mouse model of trisomy-21 dissociates properties of short- and long-term recognition memory. Neurobiology of Learning and Memory. PMID 26868479 DOI: 10.1016/J.Nlm.2016.02.002 |
0.468 |
|
| 2016 |
Lana-Elola E, Watson-Scales S, Slender A, Gibbins D, Martineau A, Douglas C, Mohun T, Fisher EM, Tybulewicz VLj. Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel. Elife. 5. PMID 26765563 DOI: 10.7554/eLife.11614 |
0.57 |
|
| 2016 |
Hall JH, Good MA, Fisher E, Wiseman FK, Harwood JL, Tybulewicz VL. P1-036: Dissociating Aberrant Memory Processes in Mouse Models of Alzheimer's Disease and Down Syndrome Alzheimer's & Dementia. 12: P414-P415. DOI: 10.1016/J.Jalz.2016.06.783 |
0.482 |
|
| 2015 |
Wiseman FK, Al-Janabi T, Hardy J, Karmiloff-Smith A, Nizetic D, Tybulewicz VL, Fisher EM, Strydom A. A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome. Nature Reviews. Neuroscience. 16: 564-74. PMID 26243569 DOI: 10.1038/Nrn3983 |
0.652 |
|
| 2015 |
Witton J, Padmashri R, Zinyuk LE, Popov VI, Kraev I, Line SJ, Jensen TP, Tedoldi A, Cummings DM, Tybulewicz VL, Fisher EM, Bannerman DM, Randall AD, Brown JT, Edwards FA, et al. Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome. Nature Neuroscience. 18: 1291-8. PMID 26237367 DOI: 10.1038/Nn.4072 |
0.493 |
|
| 2014 |
Ma D, Cardoso MJ, Modat M, Powell N, Wells J, Holmes H, Wiseman F, Tybulewicz V, Fisher E, Lythgoe MF, Ourselin S. Automatic structural parcellation of mouse brain MRI using multi-atlas label fusion. Plos One. 9: e86576. PMID 24475148 DOI: 10.1371/Journal.Pone.0086576 |
0.493 |
|
| 2013 |
Gribble SM, Wiseman FK, Clayton S, Prigmore E, Langley E, Yang F, Maguire S, Fu B, Rajan D, Sheppard O, Scott C, Hauser H, Stephens PJ, Stebbings LA, Ng BL, ... ... Tybulewicz VL, et al. Massively parallel sequencing reveals the complex structure of an irradiated human chromosome on a mouse background in the Tc1 model of Down syndrome. Plos One. 8: e60482. PMID 23596509 DOI: 10.1371/Journal.Pone.0060482 |
0.608 |
|
| 2013 |
Ahmed MM, Dhanasekaran AR, Tong S, Wiseman FK, Fisher EM, Tybulewicz VL, Gardiner KJ. Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain. Human Molecular Genetics. 22: 1709-24. PMID 23349361 DOI: 10.1093/Hmg/Ddt017 |
0.533 |
|
| 2013 |
Choong XY, Raha A, Tybulewicz V, Wiseman F, Fisher E. P1-106: Using primary neurons from transgenic mice to identify genes on human chromosome 21 influencing Alzheimer's neuropathology Alzheimer's & Dementia. 9: P189-P189. DOI: 10.1016/J.Jalz.2013.05.328 |
0.595 |
|
| 2012 |
Grizenkova J, Akhtar S, Hummerich H, Tomlinson A, Asante EA, Wenborn A, Fizet J, Poulter M, Wiseman FK, Fisher EM, Tybulewicz VL, Brandner S, Collinge J, Lloyd SE. Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice. Proceedings of the National Academy of Sciences of the United States of America. 109: 13722-7. PMID 22869728 DOI: 10.1073/Pnas.1208917109 |
0.546 |
|
| 2012 |
Sheppard O, Wiseman FK, Ruparelia A, Tybulewicz VL, Fisher EM. Mouse models of aneuploidy. Thescientificworldjournal. 2012: 214078. PMID 22262951 DOI: 10.1100/2012/214078 |
0.58 |
|
| 2012 |
Devoy A, Bunton-Stasyshyn RK, Tybulewicz VL, Smith AJ, Fisher EM. Genomically humanized mice: technologies and promises. Nature Reviews. Genetics. 13: 14-20. PMID 22179716 DOI: 10.1038/Nrg3116 |
0.493 |
|
| 2012 |
Sheppard O, Plattner F, Rubin A, Slender A, Linehan JM, Brandner S, Tybulewicz VL, Fisher EM, Wiseman FK. Altered regulation of tau phosphorylation in a mouse model of down syndrome aging. Neurobiology of Aging. 33: 828.e31-44. PMID 21843906 DOI: 10.1016/J.Neurobiolaging.2011.06.025 |
0.509 |
|
| 2011 |
Lana-Elola E, Watson-Scales SD, Fisher EM, Tybulewicz VL. Down syndrome: searching for the genetic culprits. Disease Models & Mechanisms. 4: 586-95. PMID 21878459 DOI: 10.1242/Dmm.008078 |
0.603 |
|
| 2011 |
Cleary JO, Wiseman FK, Norris FC, Price AN, Choy M, Tybulewicz VL, Ordidge RJ, Brandner S, Fisher EM, Lythgoe MF. Structural correlates of active-staining following magnetic resonance microscopy in the mouse brain. Neuroimage. 56: 974-83. PMID 21310249 DOI: 10.1016/J.Neuroimage.2011.01.082 |
0.46 |
|
| 2011 |
Duchon A, Pothion S, Brault V, Sharp AJ, Tybulewicz VL, Fisher EM, Herault Y. The telomeric part of the human chromosome 21 from Cstb to Prmt2 is not necessary for the locomotor and short-term memory deficits observed in the Tc1 mouse model of Down syndrome. Behavioural Brain Research. 217: 271-81. PMID 21047530 DOI: 10.1016/J.Bbr.2010.10.023 |
0.621 |
|
| 2010 |
Ruparelia A, Wiseman F, Sheppard O, Tybulewicz VL, Fisher EM. Down syndrome and the molecular pathogenesis resulting from trisomy of human chromosome 21. Journal of Biomedical Research. 24: 87-99. PMID 23554618 DOI: 10.1016/S1674-8301(10)60016-4 |
0.587 |
|
| 2010 |
Wiseman FK, Sheppard O, Linehan JM, Brandner S, Tybulewicz VL, Fisher EM. Generation of a panel of antibodies against proteins encoded on human chromosome 21. Journal of Negative Results in Biomedicine. 9: 7. PMID 20727138 DOI: 10.1186/1477-5751-9-7 |
0.601 |
|
| 2010 |
Dunlevy L, Bennett M, Slender A, Lana-Elola E, Tybulewicz VL, Fisher EM, Mohun T. Down's syndrome-like cardiac developmental defects in embryos of the transchromosomic Tc1 mouse. Cardiovascular Research. 88: 287-95. PMID 20558441 DOI: 10.1093/Cvr/Cvq193 |
0.573 |
|
| 2010 |
Reynolds LE, Watson AR, Baker M, Jones TA, D'Amico G, Robinson SD, Joffre C, Garrido-Urbani S, Rodriguez-Manzaneque JC, Martino-Echarri E, Aurrand-Lions M, Sheer D, Dagna-Bricarelli F, Nizetic D, McCabe CJ, ... ... Tybulewicz VL, et al. Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome. Nature. 465: 813-7. PMID 20535211 DOI: 10.1038/Nature09106 |
0.546 |
|
| 2010 |
Alford KA, Slender A, Vanes L, Li Z, Fisher EM, Nizetic D, Orkin SH, Roberts I, Tybulewicz VL. Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome. Blood. 115: 2928-37. PMID 20154221 DOI: 10.1182/Blood-2009-06-227629 |
0.576 |
|
| 2010 |
Haas M, Fisher E, Tybulewicz V, Guillemot F. [P2.56]: Cortical projection neuron dendrite morphology in the Tc1 mouse model of Down Syndrome International Journal of Developmental Neuroscience. 28: 706-706. DOI: 10.1016/J.Ijdevneu.2010.07.186 |
0.471 |
|
| 2009 |
Wiseman FK, Alford KA, Tybulewicz VL, Fisher EM. Down syndrome--recent progress and future prospects. Human Molecular Genetics. 18: R75-83. PMID 19297404 DOI: 10.1093/Hmg/Ddp010 |
0.565 |
|
| 2009 |
Galante M, Jani H, Vanes L, Daniel H, Fisher EM, Tybulewicz VL, Bliss TV, Morice E. Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndrome. Human Molecular Genetics. 18: 1449-63. PMID 19181682 DOI: 10.1093/Hmg/Ddp055 |
0.547 |
|
| 2009 |
Wang Y, Mulligan C, Denyer G, Delom F, Dagna-Bricarelli F, Tybulewicz VL, Fisher EM, Griffiths WJ, Nizetic D, Groet J. Quantitative proteomics characterization of a mouse embryonic stem cell model of Down syndrome. Molecular & Cellular Proteomics : McP. 8: 585-95. PMID 19001410 DOI: 10.1074/Mcp.M800256-Mcp200 |
0.599 |
|
| 2008 |
Wilson MD, Barbosa-Morais NL, Schmidt D, Conboy CM, Vanes L, Tybulewicz VL, Fisher EM, Tavaré S, Odom DT. Species-specific transcription in mice carrying human chromosome 21. Science (New York, N.Y.). 322: 434-8. PMID 18787134 DOI: 10.1126/Science.1160930 |
0.536 |
|
| 2008 |
Canzonetta C, Mulligan C, Deutsch S, Ruf S, O'Doherty A, Lyle R, Borel C, Lin-Marq N, Delom F, Groet J, Schnappauf F, De Vita S, Averill S, Priestley JV, Martin JE, ... ... Tybulewicz VL, et al. DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome. American Journal of Human Genetics. 83: 388-400. PMID 18771760 DOI: 10.1016/J.Ajhg.2008.08.012 |
0.555 |
|
| 2008 |
Morice E, Andreae LC, Cooke SF, Vanes L, Fisher EM, Tybulewicz VL, Bliss TV. Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome. Learning & Memory (Cold Spring Harbor, N.Y.). 15: 492-500. PMID 18626093 DOI: 10.1101/Lm.969608 |
0.503 |
|
| 2007 |
Mensah A, Mulligan C, Linehan J, Ruf S, O'Doherty A, Grygalewicz B, Shipley J, Groet J, Tybulewicz V, Fisher E, Brandner S, Nizetic D. An additional human chromosome 21 causes suppression of neural fate of pluripotent mouse embryonic stem cells in a teratoma model. Bmc Developmental Biology. 7: 131. PMID 18047653 DOI: 10.1186/1471-213X-7-131 |
0.622 |
|
| 2006 |
Tybulewicz VL, Fisher EM. New techniques to understand chromosome dosage: mouse models of aneuploidy. Human Molecular Genetics. 15: R103-9. PMID 16987872 DOI: 10.1093/Hmg/Ddl179 |
0.617 |
|
| 2005 |
O'Doherty A, Ruf S, Mulligan C, Hildreth V, Errington ML, Cooke S, Sesay A, Modino S, Vanes L, Hernandez D, Linehan JM, Sharpe PT, Brandner S, Bliss TV, Henderson DJ, ... ... Tybulewicz VL, et al. An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes. Science (New York, N.Y.). 309: 2033-7. PMID 16179473 DOI: 10.1126/science.1114535 |
0.595 |
|
| 2004 |
Wells CM, Walmsley M, Ooi S, Tybulewicz V, Ridley AJ. Rac1-deficient macrophages exhibit defects in cell spreading and membrane ruffling but not migration. Journal of Cell Science. 117: 1259-68. PMID 14996945 DOI: 10.1242/Jcs.00997 |
0.323 |
|
| 1999 |
Hernandez D, Mee PJ, Martin JE, Tybulewicz VL, Fisher EM. Transchromosomal mouse embryonic stem cell lines and chimeric mice that contain freely segregating segments of human chromosome 21. Human Molecular Genetics. 8: 923-33. PMID 10196383 DOI: 10.1093/Hmg/8.5.923 |
0.612 |
|
| 1995 |
Hernandez D, Pannett AA, Tybulewicz V, Fisher EM. Highly polymorphic sequence at D21S1448 mapping close to D21S55, within the Down syndrome critical region. Human Genetics. 95: 721-2. PMID 7789964 DOI: 10.1007/Bf00209498 |
0.594 |
|
| 1995 |
Willemsen R, Tybulewicz V, Sidransky E, Eliason WK, Martin BM, LaMarca ME, Reuser AJ, Tremblay M, Westphal H, Mulligan RC. A biochemical and ultrastructural evaluation of the type 2 Gaucher mouse. Molecular and Chemical Neuropathology. 24: 179-92. PMID 7632321 DOI: 10.1007/Bf02962142 |
0.366 |
|
| 1986 |
Gay NJ, Tybulewicz VL, Walker JE. Insertion of transposon Tn7 into the Escherichia coli glmS transcriptional terminator. The Biochemical Journal. 234: 111-7. PMID 3010949 DOI: 10.1042/Bj2340111 |
0.348 |
|
| 1985 |
Walker JE, Fearnley IM, Gay NJ, Gibson BW, Northrop FD, Powell SJ, Runswick MJ, Saraste M, Tybulewicz VL. Primary structure and subunit stoichiometry of F1-ATPase from bovine mitochondria. Journal of Molecular Biology. 184: 677-701. PMID 2864455 DOI: 10.1016/0022-2836(85)90313-4 |
0.302 |
|
| 1984 |
Walker JE, Falk G, Gay NJ, Tybulewicz VL. Genes for bacterial and mitochondrial ATP synthase. Biochemical Society Transactions. 12: 234-5. PMID 6233197 DOI: 10.1042/Bst0120234 |
0.324 |
|
| 1984 |
Tybulewicz VL, Falk G, Walker JE. Rhodopseudomonas blastica atp operon. Nucleotide sequence and transcription. Journal of Molecular Biology. 179: 185-214. PMID 6209404 DOI: 10.1016/0022-2836(84)90465-0 |
0.387 |
|
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