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Isabelle Ruel, Ph.D. - Publications

Affiliations: 
2005 Universite Laval (Canada) 
Area:
Medicine and Surgery, Pathology, Genetics
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61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Iatan I, Akioyamen LE, Ruel I, Guerin A, Hales L, Coutinho T, Brunham LR, Genest J. Sex differences in treatment of familial hypercholesterolaemia: a meta-analysis. European Heart Journal. PMID 38976372 DOI: 10.1093/eurheartj/ehae417  0.371
2024 Trinder M, Cermakova L, Ruel I, Baass A, Paquette M, Wang J, Kennedy BA, Hegele RA, Genest J, Brunham LR. Influence of Polygenic Background on the Clinical Presentation of Familial Hypercholesterolemia. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 38779854 DOI: 10.1161/ATVBAHA.123.320287  0.326
2024 Al-Baldawi Z, Brown L, Ruel I, Baass A, Bergeron J, Cermakova L, Couture P, Gaudet D, Francis GA, Hegele RA, Iatan I, Mancini GBJ, McCrindle BW, Ransom T, Sherman MH, et al. Sex differences in the presentation, treatment and outcomes of patients with homozygous familial hypercholesterolemia. Journal of Clinical Lipidology. PMID 38281851 DOI: 10.1016/j.jacl.2024.01.003  0.301
2023 Brown L, Ruel I, Baass A, Bergeron J, Brunham LR, Cermakova L, Couture P, Gaudet D, Francis GA, Hegele RA, Iatan I, Mancini GBJ, McCrindle BW, Ransom T, Sherman MH, et al. Homozygous Familial Hypercholesterolemia in Canada: An Observational Study. Jacc. Advances. 2: 100309. PMID 38939573 DOI: 10.1016/j.jacadv.2023.100309  0.433
2023 Guerin A, Iatan I, Ruel I, Ngufor LF, Genest J. Genetic testing for familial hypercholesterolemia in Quebec, Canada: a single-centre retrospective cohort study. Cmaj Open. 11: E754-E764. PMID 37607748 DOI: 10.9778/cmajo.20220108  0.316
2023 Choi HY, Iatan I, Ruel I, Brown L, Hales L, Choi S, Genest J. Docetaxel as a Model Compound to Promote HDL (High-Density Lipoprotein) Biogenesis and Reduce Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 36861478 DOI: 10.1161/ATVBAHA.122.318275  0.33
2023 Choi HY, Choi S, Iatan I, Ruel I, Genest J. Biomedical Advances in ABCA1 Transporter: From Bench to Bedside. Biomedicines. 11. PMID 36831097 DOI: 10.3390/biomedicines11020561  0.387
2021 Alothman L, Bélanger AM, Ruel I, Brunham LR, Hales L, Genest J, Akioyamen LE. Health-related quality of life in homozygous familial hypercholesterolemia: A systematic review and meta-analysis. Journal of Clinical Lipidology. 16: 52-65. PMID 35027327 DOI: 10.1016/j.jacl.2021.11.014  0.376
2021 Choi HY, Ruel I, Choi S, Genest J. New Strategies to Promote Macrophage Cholesterol Efflux. Frontiers in Cardiovascular Medicine. 8: 795868. PMID 35004908 DOI: 10.3389/fcvm.2021.795868  0.347
2021 Kramer AI, Akioyamen LE, Lee S, Bélanger A, Ruel I, Hales L, Genest J, Brunham LR. Major adverse cardiovascular events in homozygous familial hypercholesterolaemia: a systematic review and meta-analysis. European Journal of Preventive Cardiology. PMID 34957506 DOI: 10.1093/eurjpc/zwab224  0.329
2021 Roy G, Couture P, Genest J, Ruel I, Baass A, Bergeron J, Brisson D, Brunham LR, Cermakova L, Gaudet D, Khoury E, Laflamme N, Kennedy BA, Hegele RA, Drouin-Chartier JP. Influence of the LDL-receptor genotype on statin response in heterozygous familial hypercholesterolemia: insights from the Canadian FH Registry. The Canadian Journal of Cardiology. PMID 34774719 DOI: 10.1016/j.cjca.2021.10.013  0.36
2020 Aljenedil S, Alothman L, Bélanger AM, Brown L, Lahijanian Z, Bergeron J, Couture P, Baass A, Ruel I, Brisson D, Khoury E, Gaudet D, Genest J. Lomitapide for treatment of homozygous familial hypercholesterolemia: The Québec experience. Atherosclerosis. 310: 54-63. PMID 32906018 DOI: 10.1016/J.Atherosclerosis.2020.07.028  0.456
2019 Alothman L, Zawadka M, Aljenedil S, Kajil M, Bewick D, Gaudet D, Hegele RA, Lonn E, Ngui D, Ruel I, Tsigoulis M, Singh N, Genest J, Gupta M. Prediction of Familial Hypercholesterolemia in Patients at High Atherosclerotic Cardiovascular Disease Risk Using a Recently Validated Algorithm. Cjc Open. 1: 190-197. PMID 32159106 DOI: 10.1016/j.cjco.2019.05.006  0.366
2019 Banerjee A, Alothman L, Couture P, Bergeron J, Bélanger AM, Ruel I, Genest J. The Lifelong Burden of Homozygous Familial Hypercholesterolemia. The Canadian Journal of Cardiology. PMID 31521416 DOI: 10.1016/J.Cjca.2019.06.009  0.446
2019 Lee S, Akioyamen LE, Aljenedil S, Rivière JB, Ruel I, Genest J. Genetic testing for familial hypercholesterolemia: Impact on diagnosis, treatment and cardiovascular risk. European Journal of Preventive Cardiology. 2047487319829746. PMID 30755017 DOI: 10.1177/2047487319829746  0.453
2019 Gupta M, Zawadka M, Aljenedil S, Kajil M, Bewick D, Gaudet D, Hegele R, Lonn E, Ngui D, Alothman L, Ruel I, Singh N, Genest J. THE HIGH PREVALENCE OF FAMILIAL HYPERCHOLESTEROLEMIA IN A POPULATION OF ASCVD PATIENTS WITH LDL-C ABOVE TARGET: AN ANALYSIS FROM THE REACT REGISTRY Journal of the American College of Cardiology. 73: 90. DOI: 10.1016/J.Cjca.2018.07.374  0.378
2018 Brunham LR, Ruel I, Aljenedil S, Rivière JB, Baass A, Tu JV, Mancini GBJ, Raggi P, Gupta M, Couture P, Pearson GJ, Bergeron J, Francis GA, McCrindle BW, Morrison K, et al. Canadian Cardiovascular Society Position Statement on Familial Hypercholesterolemia: Update 2018. The Canadian Journal of Cardiology. 34: 1553-1563. PMID 30527143 DOI: 10.1016/J.Cjca.2018.09.005  0.44
2018 Paquette M, Bernard S, Ruel I, Blank DW, Genest J, Baass A. Diabetes is associated with an increased risk of cardiovascular disease in patients with familial hypercholesterolemia. Journal of Clinical Lipidology. PMID 30318454 DOI: 10.1016/J.Jacl.2018.09.008  0.394
2018 Brunham LR, Ruel I, Khoury E, Hegele RA, Couture P, Bergeron J, Baass A, Dufour R, Francis GA, Cermakova L, Mancini GBJ, Brophy JM, Brisson D, Gaudet D, Genest J. Familial hypercholesterolemia in Canada: Initial results from the FH Canada national registry. Atherosclerosis. 277: 419-424. PMID 30270080 DOI: 10.1016/J.Atherosclerosis.2018.05.040  0.307
2018 Ruel I, Brisson D, Aljenedil S, Awan Z, Baass A, Bélanger A, Bergeron J, Bewick D, Brophy JM, Brunham LR, Couture P, Dufour R, Francis GA, Frohlich J, Gagné C, et al. Simplified Canadian Definition for Familial Hypercholesterolemia. The Canadian Journal of Cardiology. PMID 30093300 DOI: 10.1016/J.Cjca.2018.05.015  0.47
2018 Aljenedil S, Ruel I, Watters K, Genest J. Severe xanthomatosis in heterozygous familial hypercholesterolemia. Journal of Clinical Lipidology. PMID 29778561 DOI: 10.1016/J.Jacl.2018.03.087  0.53
2018 St-Pierre J, Ruel I, Genest J. The Essential Role of Primary Caregiver in Early Detection of Familial Hypercholesterolemia and Cardiovascular Prevention. Current Pediatric Reviews. PMID 29473516 DOI: 10.2174/1573396314666180221162556  0.337
2018 Aljenedil S, Ruel I, Brisson D, Awan Z, Baass A, Bélanger A, Bewick D, Bergeron J, Brophy JM, Brunham LR, Couture P, Dufour R, Francis GA, Frohlich J, Gagné C, et al. Canadian Definition for Familial Hypercholesterolemia Atherosclerosis Supplements. 32: 55-56. DOI: 10.1016/J.Atherosclerosissup.2018.04.167  0.302
2018 Ruel I, Aljenedil S, Brophy J, Gaudet D, McCrindle B, Frohlich J, Hegele R, Genest J. Update on the Familial Hypercholesterolemia Canada (FH Canada) Registry Atherosclerosis Supplements. 32: 51-52. DOI: 10.1016/J.Atherosclerosissup.2018.04.155  0.302
2017 Choi HY, Ruel I, Malina A, Garrod DR, Oda MN, Pelletier J, Schwertani A, Genest J. Desmocollin 1 is abundantly expressed in atherosclerosis and impairs high-density lipoprotein biogenesis. European Heart Journal. PMID 29106519 DOI: 10.1016/J.Atherosclerosissup.2018.04.080  0.481
2017 Ruel I, Aljenedil S, Sadri I, de Varennes É, Hegele RA, Couture P, Bergeron J, Wanneh E, Baass A, Dufour R, Gaudet D, Brisson D, Brunham LR, Francis GA, Cermakova L, et al. Imputation of Baseline LDL Cholesterol Concentration in Patients with Familial Hypercholesterolemia on Statins or Ezetimibe. Clinical Chemistry. PMID 29038147 DOI: 10.1373/Clinchem.2017.279422  0.515
2017 Al Kindi M, Bélanger AM, Sayegh K, Senouci S, Aljenedil S, Sivakumaran L, Ruel I, Al Rasadi K, Al Waili K, Awan Z, Valenti D, Genest J. Aortic Calcification Progression in Heterozygote Familial Hypercholesterolemia. The Canadian Journal of Cardiology. 33: 658-665. PMID 28449836 DOI: 10.1016/J.Cjca.2017.02.001  0.307
2014 Genest J, Hegele RA, Bergeron J, Brophy J, Carpentier A, Couture P, Davignon J, Dufour R, Frohlich J, Gaudet D, Gupta M, Krisnamoorthy P, Mancini J, McCrindle B, ... ... Ruel I, et al. Canadian Cardiovascular Society position statement on familial hypercholesterolemia. The Canadian Journal of Cardiology. 30: 1471-81. PMID 25448461 DOI: 10.1016/J.Cjca.2014.09.028  0.458
2014 Iatan I, Choi HY, Ruel I, Reddy MV, Kil H, Lee J, Odeh MA, Salah Z, Abu-Remaileh M, Weissglas-Volkov D, Nikkola E, Civelek M, Awan Z, Croce CM, Aqeilan RI, et al. The WWOX gene modulates high-density lipoprotein and lipid metabolism. Circulation. Cardiovascular Genetics. 7: 491-504. PMID 24871327 DOI: 10.1161/Circgenetics.113.000248  0.509
2014 Hafiane A, Jabor B, Ruel I, Ling J, Genest J. High-density lipoprotein mediated cellular cholesterol efflux in acute coronary syndromes. The American Journal of Cardiology. 113: 249-55. PMID 24210679 DOI: 10.1016/J.Amjcard.2013.09.006  0.52
2013 Jabor B, Choi H, Ruel I, Hafiane A, Mourad W, Genest J. Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) in acute coronary syndrome: relationship with low-density lipoprotein cholesterol. The Canadian Journal of Cardiology. 29: 1679-86. PMID 24267807 DOI: 10.1016/J.Cjca.2013.09.026  0.401
2013 Awan Z, Choi HY, Stitziel N, Ruel I, Bamimore MA, Husa R, Gagnon MH, Wang RH, Peloso GM, Hegele RA, Seidah NG, Kathiresan S, Genest J. APOE p.Leu167del mutation in familial hypercholesterolemia. Atherosclerosis. 231: 218-22. PMID 24267230 DOI: 10.1016/J.Cjca.2013.07.652  0.413
2013 Hirtle-Lewis M, Desbiens K, Ruel I, Rudzicz N, Genest J, Engert JC, Giannetti N. The genetics of dilated cardiomyopathy: a prioritized candidate gene study of LMNA, TNNT2, TCAP, and PLN. Clinical Cardiology. 36: 628-33. PMID 24037902 DOI: 10.1002/Clc.22193  0.344
2013 Lee CY, Ruel I, Denis M, Genest J, Kiss RS. Cholesterol trapping in Niemann-Pick disease type B fibroblasts can be relieved by expressing the phosphotyrosine binding domain of GULP. Journal of Clinical Lipidology. 7: 153-64. PMID 23415435 DOI: 10.1016/J.Jacl.2012.02.006  0.41
2012 Reddy MV, Iatan I, Weissglas-Volkov D, Nikkola E, Haas BE, Juvonen M, Ruel I, Ruel MJ, Sinsheimer JS, Genest J, Pajukanta P. Exome sequencing identifies 2 rare variants for low high-density lipoprotein cholesterol in an extended family. Circulation. Cardiovascular Genetics. 5: 538-46. PMID 22923419 DOI: 10.1161/Circgenetics.112.963264  0.483
2012 Iatan I, Palmyre A, Alrasheed S, Ruel I, Genest J. Genetics of cholesterol efflux. Current Atherosclerosis Reports. 14: 235-46. PMID 22528521 DOI: 10.1007/S11883-012-0247-Y  0.526
2012 Alwaili K, Bailey D, Awan Z, Bailey SD, Ruel I, Hafiane A, Krimbou L, Laboissiere S, Genest J. The HDL proteome in acute coronary syndromes shifts to an inflammatory profile. Biochimica Et Biophysica Acta. 1821: 405-15. PMID 21840418 DOI: 10.1016/J.Bbalip.2011.07.013  0.454
2011 Iatan I, Bailey D, Ruel I, Hafiane A, Campbell S, Krimbou L, Genest J. Membrane microdomains modulate oligomeric ABCA1 function: impact on apoAI-mediated lipid removal and phosphatidylcholine biosynthesis. Journal of Lipid Research. 52: 2043-55. PMID 21846716 DOI: 10.1194/Jlr.M016196  0.408
2010 Dastani Z, Pajukanta P, Marcil M, Rudzicz N, Ruel I, Bailey SD, Lee JC, Lemire M, Faith J, Platko J, Rioux J, Hudson TJ, Gaudet D, Engert JC, Genest J. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. European Journal of Human Genetics : Ejhg. 18: 342-7. PMID 19844255 DOI: 10.1038/Ejhg.2009.157  0.426
2010 Bailey D, Ruel I, Hafiane A, Cochrane H, Iatan I, Jauhiainen M, Ehnholm C, Krimbou L, Genest J. Analysis of lipid transfer activity between model nascent HDL particles and plasma lipoproteins: implications for current concepts of nascent HDL maturation and genesis. Journal of Lipid Research. 51: 785-97. PMID 19797257 DOI: 10.1194/Jlr.M001875  0.497
2009 Iatan I, Dastani Z, Do R, Weissglas-Volkov D, Ruel I, Lee JC, Huertas-Vazquez A, Taskinen MR, Prat A, Seidah NG, Pajukanta P, Engert JC, Genest J. Genetic variation at the proprotein convertase subtilisin/kexin type 5 gene modulates high-density lipoprotein cholesterol levels. Circulation. Cardiovascular Genetics. 2: 467-75. PMID 20031622 DOI: 10.1161/Circgenetics.109.877811  0.505
2009 Rashid S, Marcil M, Ruel I, Genest J. Identification of a novel human cellular HDL biosynthesis defect. European Heart Journal. 30: 2204-12. PMID 19553242 DOI: 10.1093/Eurheartj/Ehp250  0.507
2008 Alrasadi K, Awan Z, Alwaili K, Ruel I, Hafiane A, Krimbou L, Genest J. Comparison of treatment of severe high-density lipoprotein cholesterol deficiency in men with daily atorvastatin (20 mg) versus fenofibrate (200 mg) versus extended-release niacin (2 g). The American Journal of Cardiology. 102: 1341-7. PMID 18993152 DOI: 10.1016/J.Amjcard.2008.07.010  0.519
2008 Iatan I, Alrasadi K, Ruel I, Alwaili K, Genest J. Effect of ABCA1 mutations on risk for myocardial infarction. Current Atherosclerosis Reports. 10: 413-26. PMID 18706283 DOI: 10.1007/S11883-008-0064-5  0.516
2008 Hassan HH, Bailey D, Lee DY, Iatan I, Hafiane A, Ruel I, Krimbou L, Genest J. Quantitative analysis of ABCA1-dependent compartmentalization and trafficking of apolipoprotein A-I: implications for determining cellular kinetics of nascent high density lipoprotein biogenesis. The Journal of Biological Chemistry. 283: 11164-75. PMID 18218626 DOI: 10.1074/Jbc.M707720200  0.444
2008 Desroches S, Ruel IL, Deshaies Y, Paradis ME, Archer WR, Couture P, Bergeron N, Lamarche B. Kinetics of plasma apolipoprotein C-III as a determinant of diet-induced changes in plasma triglyceride levels. European Journal of Clinical Nutrition. 62: 10-7. PMID 17299465 DOI: 10.1038/sj.ejcn.1602673  0.66
2008 Krimbou L, Ruel I, Dastani Z, Alrasadi K, Hajj Hassan H, Iatan I, Marcil M, Genest J. Disorders of high‐density lipoprotein biogenesis Annals of Medicine. 40: 39-47. DOI: 10.1080/07853890701689637  0.506
2007 Dastani Z, Ruel IL, Engert JC, Genest J, Marcil M. Sphingomyelin phosphodiesterase-1 (SMPD1) coding variants do not contribute to low levels of high-density lipoprotein cholesterol. Bmc Medical Genetics. 8: 79. PMID 18088425 DOI: 10.1186/1471-2350-8-79  0.468
2007 Hassan HH, Denis M, Lee DY, Iatan I, Nyholt D, Ruel I, Krimbou L, Genest J. Identification of an ABCA1-dependent phospholipid-rich plasma membrane apolipoprotein A-I binding site for nascent HDL formation: implications for current models of HDL biogenesis. Journal of Lipid Research. 48: 2428-42. PMID 17656736 DOI: 10.1194/Jlr.M700206-Jlr200  0.378
2006 Alrasadi K, Ruel IL, Marcil M, Genest J. Functional mutations of the ABCA1 gene in subjects of French-Canadian descent with HDL deficiency. Atherosclerosis. 188: 281-91. PMID 16343503 DOI: 10.1016/J.Atherosclerosis.2005.10.048  0.345
2006 Tremblay AJ, Lamarche B, Ruel IL, Hogue JC, Deshaies Y, Gagné C, Couture P. Effects of fenofibrate on apolipoprotein kinetics in patients with coexisting dysbetalipoproteinemia and heterozygous familial hypercholesterolemia. Atherosclerosis. 188: 203-12. PMID 16337207 DOI: 10.1016/J.Atherosclerosis.2005.10.037  0.52
2005 Ruel IL, Lamarche B, Mauger JF, Badellino KO, Cohn JS, Marcil M, Couture P. Effect of fenofibrate on plasma lipoprotein composition and kinetics in patients with complete hepatic lipase deficiency. Arteriosclerosis, Thrombosis, and Vascular Biology. 25: 2600-7. PMID 16224048 DOI: 10.1161/01.Atv.0000190700.76493.Bb  0.504
2005 Ruel IL, Couture P, Cohn JS, Lamarche B. Plasma metabolism of apoB-containing lipoproteins in patients with hepatic lipase deficiency. Atherosclerosis. 180: 355-66. PMID 15910863 DOI: 10.1016/J.Atherosclerosis.2004.12.014  0.551
2004 Ruel IL, Couture P, Cohn JS, Bensadoun A, Marcil M, Lamarche B. Evidence that hepatic lipase deficiency in humans is not associated with proatherogenic changes in HDL composition and metabolism. Journal of Lipid Research. 45: 1528-37. PMID 15175359 DOI: 10.1194/Jlr.M400090-Jlr200  0.581
2004 Tremblay AJ, Lamarche B, Ruel I, Hogue JC, Bergeron J, Gagné C, Couture P. Lack of evidence for reduced plasma apo B48 catabolism in patients with heterozygous familial hypercholesterolemia carrying the same null LDL receptor gene mutation. Atherosclerosis. 172: 367-73. PMID 15019548 DOI: 10.1016/J.Atherosclerosis.2003.11.011  0.613
2004 Tremblay AJ, Lamarche B, Ruel IL, Hogue JC, Bergeron J, Gagné C, Couture P. Increased production of VLDL apoB-100 in subjects with familial hypercholesterolemia carrying the same null LDL receptor gene mutation. Journal of Lipid Research. 45: 866-72. PMID 14967814 DOI: 10.1194/Jlr.M300448-Jlr200  0.623
2003 Ruel IL, Couture P, Gagne C, Deshaies Y, Simard J, Hegele RA, Lamarche B. Characterization of a novel mutation causing hepatic lipase deficiency among French Canadians. Journal of Lipid Research. 44: 1508-14. PMID 12777476 DOI: 10.1194/Jlr.M200479-Jlr200  0.548
2003 Ruel IL, Gaudet D, Perron P, Bergeron J, Julien P, Lamarche B. Effect of obesity on HDL and LDL particle sizes in carriers of the null P207L or defective D9N mutation in the lipoprotein lipase gene: the Québec LipD Study. International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association For the Study of Obesity. 27: 631-7. PMID 12704407 DOI: 10.1038/Sj.Ijo.0802276  0.586
2002 Ruel IL, Gaudet D, Perron P, Bergeron J, Julien P, Lamarche B. Characterization of LDL particle size among carriers of a defective or a null mutation in the lipoprotein lipase gene: the Québec LIPD Study. Arteriosclerosis, Thrombosis, and Vascular Biology. 22: 1181-6. PMID 12117735 DOI: 10.1161/01.Atv.0000020677.33243.1C  0.498
2002 Ruel IL, Gaudet D, Perron P, Pascot A, Després JP, Bergeron J, Julien P, Lamarche B. Determinants of HDL particle size in patients with the null (P207L) or defective (D9N) mutation in the lipoprotein lipase gene: the Québec LipD Study. Atherosclerosis. 162: 269-76. PMID 11996946 DOI: 10.1016/S0021-9150(01)00716-X  0.553
2001 St-Pierre AC, Ruel IL, Cantin B, Dagenais GR, Bernard PM, Després JP, Lamarche B. Comparison of various electrophoretic characteristics of LDL particles and their relationship to the risk of ischemic heart disease. Circulation. 104: 2295-9. PMID 11696468 DOI: 10.1161/Hc4401.098490  0.474
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