| Year |
Citation |
Score |
| 1996 |
Hillman AL, Brenner MK, Caplan AL, Carey J, Champey Y, Culver KW, Drummond MF, Freund DA, Holmes EW, Kelley WN, Kolata G, Levine MN, Levy E, Schondelmeyer SW, Velu T, et al. Gene therapy: socioeconomic and ethical issues. A roundtable discussion. Human Gene Therapy. 7: 1139-44. PMID 8773516 DOI: 10.1089/Hum.1996.7.9-1139 |
0.371 |
|
| 1991 |
Tarlé SA, Davidson BL, Wu VC, Zidar FJ, Seegmiller JE, Kelley WN, Palella TD. Determination of the mutations responsible for the Lesch-Nyhan syndrome in 17 subjects. Genomics. 10: 499-501. PMID 2071157 DOI: 10.1016/0888-7543(91)90341-B |
0.657 |
|
| 1991 |
Davidson BL, Tarlé SA, Van Antwerp M, Gibbs DA, Watts RW, Kelley WN, Palella TD. Identification of 17 independent mutations responsible for human hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency. American Journal of Human Genetics. 48: 951-8. PMID 2018042 |
0.549 |
|
| 1989 |
Fujimori S, Davidson BL, Kelley WN, Palella TD. Identification of a single nucleotide change in the hypoxanthine-guanine phosphoribosyltransferase gene (HPRTYale) responsible for Lesch-Nyhan syndrome. The Journal of Clinical Investigation. 83: 11-3. PMID 2910902 DOI: 10.1172/Jci113846 |
0.559 |
|
| 1989 |
Davidson BL, Pashmforoush M, Kelley WN, Palella TD. Human hypoxanthine-guanine phosphoribosyltransferase deficiency. The molecular defect in a patient with gout (HPRTAshville). The Journal of Biological Chemistry. 264: 520-5. PMID 2909537 |
0.53 |
|
| 1989 |
Davidson BL, Tarlé SA, Palella TD, Kelley WN. Molecular basis of hypoxanthine-guanine phosphoribosyltransferase deficiency in ten subjects determined by direct sequencing of amplified transcripts. The Journal of Clinical Investigation. 84: 342-6. PMID 2738157 DOI: 10.1172/Jci114160 |
0.556 |
|
| 1989 |
Hidaka Y, Tarle SA, Kamatani N, Kelley WN, Palella TD. Human adenine phosphoribosyltransferase (APRT) deficiency: single mutant allele common to the Japanese. Advances in Experimental Medicine and Biology. 253: 43-9. PMID 2624223 DOI: 10.1007/978-1-4684-5673-8_7 |
0.391 |
|
| 1989 |
Davidson BL, Palella TD, Fujimori S, Kelley WN. Structural consequences of point mutations in nine human HPRT variants. Advances in Experimental Medicine and Biology. 253: 139-43. PMID 2624183 DOI: 10.1007/978-1-4684-5673-8_22 |
0.571 |
|
| 1989 |
Fujimori S, Davidson BL, Kelley WN, Palella TD. Lesch-Nyhan syndrome due to a single nucleotide change in the hypoxanthine-guanine phosphoribosyltransferase gene (HPRTYale). Advances in Experimental Medicine and Biology. 253: 135-8. PMID 2624182 DOI: 10.1007/978-1-4684-5673-8_21 |
0.548 |
|
| 1989 |
Palella TD, Silverman LJ, Homa FL, Levine M, Kelley WN. Transfer of human HPRT gene sequences into neuronal cells by a herpes simplex virus derived vector. Advances in Experimental Medicine and Biology. 253: 549-54. PMID 2560339 DOI: 10.1007/978-1-4684-5673-8_89 |
0.382 |
|
| 1989 |
Palella TD, Hidaka Y, Silverman LJ, Levine M, Glorioso J, Kelley WN. Expression of human HPRT mRNA in brains of mice infected with a recombinant herpes simplex virus-1 vector. Gene. 80: 137-44. PMID 2551779 DOI: 10.1016/0378-1119(89)90258-8 |
0.306 |
|
| 1988 |
Davidson BL, Pashmforoush M, Kelley WN, Palella TD. Genetic basis of hypoxanthine guanine phosphoribosyltransferase deficiency in a patient with the Lesch-Nyhan syndrome (HPRTFlint). Gene. 63: 331-6. PMID 3384338 DOI: 10.1016/0378-1119(88)90536-7 |
0.562 |
|
| 1988 |
Hidaka Y, Tarlé SA, Fujimori S, Kamatani N, Kelley WN, Palella TD. Human adenine phosphoribosyltransferase deficiency. Demonstration of a single mutant allele common to the Japanese. The Journal of Clinical Investigation. 81: 945-50. PMID 3343350 DOI: 10.1172/Jci113408 |
0.345 |
|
| 1988 |
Davidson BL, Palella TD, Kelley WN. Human hypoxanthine-guanine phosphoribosyltransferase: a single nucleotide substitution in cDNA clones isolated from a patient with Lesch-Nyhan syndrome (HPRTMidland). Gene. 68: 85-91. PMID 3265398 DOI: 10.1016/0378-1119(88)90601-4 |
0.572 |
|
| 1988 |
Davidson BL, Chin SJ, Wilson JM, Kelley WN, Palella TD. Hypoxanthine-guanine phosphoribosyltransferase. Genetic evidence for identical mutations in two partially deficient subjects. The Journal of Clinical Investigation. 82: 2164-7. PMID 3198771 DOI: 10.1172/Jci113839 |
0.598 |
|
| 1988 |
Fujimori S, Hidaka Y, Davidson BL, Palella TD, Kelley WN. Identification of a single nucleotide change in a mutant gene for hypoxanthine-guanine phosphoribosyltransferase (HPRT Ann Arbor). Human Genetics. 79: 39-43. PMID 2896620 DOI: 10.1007/Bf00291707 |
0.567 |
|
| 1988 |
Hidaka Y, Tarle SA, Kamatani N, Kelley WN, Palella TD. 55 Human Adenine Phosphoribosyltransferase (Aprt) Deficiency: A Single Mutant Allele Common To The Japanese Pediatric Research. 24: 120-120. DOI: 10.1203/00006450-198807000-00079 |
0.329 |
|
| 1988 |
Fujimori S, Davidson BL, Palella TD, Kelley WN. 38 LESCH-NYHAN SYNDROME DUE TO A SINGLE NUCLEOTIDE CHANGE IN THE HYPOXANTHINE-GUANIJE PHOSPHORIBOSYL-TRANSFERASE GENE (HPRT Yale ) Pediatric Research. 24: 117-117. DOI: 10.1203/00006450-198807000-00062 |
0.571 |
|
| 1988 |
Davidson BL, Palella TD, Fujimori S, Kelley WN. 27 Structural Consequences Of Point Mutations In Nine Human Hprt Variants Pediatric Research. 24: 115-115. DOI: 10.1203/00006450-198807000-00051 |
0.519 |
|
| 1987 |
Hidaka Y, Palella TD, O'Toole TE, Tarlé SA, Kelley WN. Human adenine phosphoribosyltransferase. Identification of allelic mutations at the nucleotide level as a cause of complete deficiency of the enzyme. The Journal of Clinical Investigation. 80: 1409-15. PMID 3680503 DOI: 10.1172/Jci113219 |
0.391 |
|
| 1987 |
Fox IH, Palella TD, Kelley WN. Hyperuricemia: a marker for cell energy crisis. The New England Journal of Medicine. 317: 111-2. PMID 3473283 DOI: 10.1056/Nejm198707093170209 |
0.325 |
|
| 1987 |
Silverman LJ, Kelley WN, Palella TD. Genetic analysis of human hypoxanthine-guanine phosphoribosyltransferase deficiency. Enzyme. 38: 36-44. PMID 2894305 |
0.366 |
|
| 1986 |
Wilson JM, Stout JT, Palella TD, Davidson BL, Kelley WN, Caskey CT. A molecular survey of hypoxanthine-guanine phosphoribosyltransferase deficiency in man. The Journal of Clinical Investigation. 77: 188-95. PMID 3944251 DOI: 10.1172/Jci112275 |
0.635 |
|
| 1986 |
Kelley WN, Searle JG, Wilson JM. HGPRT-deficiency--the molecular basis of the clinical syndromes. Verhandlungen Der Deutschen Gesellschaft FüR Innere Medizin. 92: 465-9. PMID 3811548 DOI: 10.1007/978-3-642-85459-0_91 |
0.52 |
|
| 1986 |
Wilson JM, O'Toole TE, Argos P, Shewach DS, Daddona PE, Kelley WN. Human adenine phosphoribosyltransferase. Complete amino acid sequence of the erythrocyte enzyme. The Journal of Biological Chemistry. 261: 13677-83. PMID 3531209 |
0.409 |
|
| 1985 |
Wilson JM, Kelley WN. Molecular genetics of hypoxanthine-guanine phosphoribosyltransferase deficiency in man. Archives of Internal Medicine. 145: 1895-1900. PMID 3899038 DOI: 10.1001/Archinte.1985.00360100165027 |
0.525 |
|
| 1985 |
Daddona PE, Orkin SH, Shewach DS, Kelley WN. cDNA and amino acid sequence of human adenosine deaminase. Annals of the New York Academy of Sciences. 451: 238-44. PMID 3878119 DOI: 10.1111/J.1749-6632.1985.Tb27114.X |
0.453 |
|
| 1985 |
Daddona PE, Davidson BL, Perignon JL, Kelley WN. Genetic expression in partial adenosine deaminase deficiency. mRNA levels and protein turnover for the enzyme variants in human B-lymphoblast cell lines. The Journal of Biological Chemistry. 260: 3875-80. PMID 3871777 |
0.517 |
|
| 1985 |
Orkin SH, Goff SC, Kelley WN, Daddona PE. Transient expression of human adenosine deaminase cDNAs: identification of a nonfunctional clone resulting from a single amino acid substitution. Molecular and Cellular Biology. 5: 762-7. PMID 3838797 DOI: 10.1128/Mcb.5.4.762 |
0.416 |
|
| 1985 |
Davidson BJ, Palella TD, Wilson JM, Doddona PE, O'Toole T, Kelley WN. A MOLECULAR SURVEY OF HPRT DEFICIENCY: 48 Pediatric Research. 19: 751-751. DOI: 10.1203/00006450-198507000-00068 |
0.511 |
|
| 1985 |
Daddono PE, Orkin SH, Kelley WN. Expression Defects Of Mutant Human Adenosine Deaminase: 42 Pediatric Research. 19: 750-750. DOI: 10.1203/00006450-198507000-00062 |
0.434 |
|
| 1984 |
Wilson JM, Tarr GE, Kelley WN. The primary structure and posttranslational modification of human hypoxanthine-guanine phosphoribosyltransferase. Advances in Experimental Medicine and Biology. 165: 39-44. PMID 6720436 DOI: 10.1007/978-1-4757-0390-0_8 |
0.516 |
|
| 1984 |
Wilson JM, Baugher BW, Kelley WN. Hypoxanthine-guanine phosphoribosyltransferase in human lymphoblastoid cells: confirmation of four structural variants and demonstration of a new variant (HPRT Ann Arbor). Advances in Experimental Medicine and Biology. 165: 33-8. PMID 6720433 DOI: 10.1007/978-1-4757-0390-0_7 |
0.533 |
|
| 1984 |
Wilson JM, Daddona PE, Simmonds HA, Kelley WN. Genetic mechanism(s) responsible for a deficiency of adenine phosphoribosyltransferase in man. Advances in Experimental Medicine and Biology. 165: 385-9. PMID 6720407 DOI: 10.1007/978-1-4684-4553-4_76 |
0.506 |
|
| 1984 |
Wilson JM, Kelley WN. Human hypoxanthine-guanine phosphoribosyltransferase. Structural alteration in a dysfunctional enzyme variant (HPRTMunich) isolated from a patient with gout. The Journal of Biological Chemistry. 259: 27-30. PMID 6706936 |
0.467 |
|
| 1984 |
Kazmers IS, Dalke AP, Daddona PE, Kelley WN. Sensitivity of human T and B lymphoblasts to immunoregulatory drugs. Advances in Experimental Medicine and Biology. 165: 211-4. PMID 6609534 DOI: 10.1007/978-1-4757-0390-0_42 |
0.309 |
|
| 1984 |
Wilson JM, Kelley WN. Molecular genetics of the HPRT-deficiency syndromes. Hospital Practice (Office Ed.). 19: 81-9, 93-7, 100. PMID 6425346 DOI: 10.1080/21548331.1984.11702819 |
0.437 |
|
| 1983 |
Kelley WN, Wilson JM. Human hypoxanthine-guanine phosphoribosyltransferase: studies of the normal and five mutant forms of the enzyme. Transactions of the American Clinical and Climatological Association. 94: 91-9. PMID 7186238 |
0.432 |
|
| 1983 |
Wilson JM, Kelley WN. Molecular basis of hypoxanthine-guanine phosphoribosyltransferase deficiency in a patient with the Lesch-Nyhan syndrome. The Journal of Clinical Investigation. 71: 1331-5. PMID 6853716 DOI: 10.1172/Jci110884 |
0.529 |
|
| 1983 |
Wilson JM, Kobayashi R, Fox IH, Kelley WN. Human hypoxanthine-guanine phosphoribosyltransferase. The Journal of Biological Chemistry. 258: 6458-60. PMID 6853490 |
0.415 |
|
| 1983 |
O'Toole TE, Wilson JM, Gault MH, Kelley WN. Human adenine phosphoribosyltransferase: characterization from subjects with a deficiency of enzyme activity. Biochemical Genetics. 21: 1121-34. PMID 6670989 DOI: 10.1007/Bf00488464 |
0.491 |
|
| 1983 |
Wilson JM, Tarr GE, Kelley WN. Human hypoxanthine (guanine) phosphoribosyltransferase: an amino acid substitution in a mutant form of the enzyme isolated from a patient with gout. Proceedings of the National Academy of Sciences of the United States of America. 80: 870-3. PMID 6572373 DOI: 10.1073/Pnas.80.3.870 |
0.537 |
|
| 1983 |
Argos P, Hanei M, Wilson JM, Kelley WN. A possible nucleotide-binding domain in the tertiary fold of phosphoribosyltransferases. The Journal of Biological Chemistry. 258: 6450-7. PMID 6343377 |
0.357 |
|
| 1983 |
Wilson JM, Frossard P, Nussbaum RL, Caskey CT, Kelley WN. Human hypoxanthine-guanine phosphoribosyltransferase. Detection of a mutant allele by restriction endonuclease analysis. The Journal of Clinical Investigation. 72: 767-72. PMID 6309910 DOI: 10.1172/Jci111047 |
0.486 |
|
| 1983 |
Wilson JM, Young AB, Kelley WN. Hypoxanthine-guanine phosphoribosyltransferase deficiency. The molecular basis of the clinical syndromes. The New England Journal of Medicine. 309: 900-10. PMID 6136913 DOI: 10.1056/Nejm198310133091507 |
0.517 |
|
| 1982 |
Wilson JM, Landa LE, Kobayashi R, Kelley WN. Human hypoxanthine-guanine phosphoribosyltransferase. Tryptic peptides and post-translational modification of the erythrocyte enzyme. The Journal of Biological Chemistry. 257: 14830-4. PMID 7174669 |
0.328 |
|
| 1982 |
Rassin DK, Lloyd KG, Kelley WN, Fox I. Decreased amino acids in various brain areas of patients with Lesch-Nyhan syndrome. Neuropediatrics. 13: 130-4. PMID 7133331 DOI: 10.1055/S-2008-1059611 |
0.363 |
|
| 1982 |
Wilson JM, Tarr GE, Mahoney WC, Kelley WN. Human hypoxanthine-guanine phosphoribosyltransferase. Complete amino acid sequence of the erythrocyte enzyme. The Journal of Biological Chemistry. 257: 10978-85. PMID 7107641 |
0.399 |
|
| 1982 |
Wilson JM, Daddona PE, Otoadese T, Kelley WN. Adenine phosphoribosyltransferase in patients with disorders of purine and pyrimidine metabolism. The Journal of Laboratory and Clinical Medicine. 99: 163-74. PMID 7061917 |
0.428 |
|
| 1982 |
Wilson JM, Baugher BW, Mattes PM, Daddona PE, Kelley WN. Human hypoxanthine-guanine phosphoribosyltransferase. Demonstration of structural variants in lymphoblastoid cells derived from patients with a deficiency of the enzyme. The Journal of Clinical Investigation. 69: 706-15. PMID 7061709 DOI: 10.1172/Jci110499 |
0.532 |
|
| 1982 |
Wilson JM, Daddona PE, Simmonds HA, Van Acker KJ, Kelley WN. Human adenine phosphoribosyltransferase. Immunochemical quantitation and protein blot analysis of mutant forms of the enzyme. The Journal of Biological Chemistry. 257: 1508-15. PMID 7056730 |
0.465 |
|
| 1982 |
Daddona PE, Kelley WN. Control of adenosine deaminase levels in human lymphoblasts. Advances in Enzyme Regulation. 20: 153-63. PMID 6981287 DOI: 10.1016/0065-2571(82)90014-0 |
0.32 |
|
| 1981 |
Daddona PE, Frohman MA, Kelley WN. Radioimmunoassay of human adenosine deaminase. Methods in Enzymology. 74: 351-8. PMID 7321887 DOI: 10.1016/0076-6879(81)74025-4 |
0.322 |
|
| 1981 |
Wilson JM, Baugher BW, Landa L, Kelley WN. Human hypoxanthine-guanine phosphoribosyltransferase. Purification and characterization of mutant forms of the enzyme. The Journal of Biological Chemistry. 256: 10306-12. PMID 7287714 |
0.398 |
|
| 1981 |
Daddona PE, Kelley WN. Characteristics of an aminohydrolase distinct from adenosine deaminase in cultured human lymphoblasts. Biochimica Et Biophysica Acta. 658: 280-90. PMID 6972784 DOI: 10.1016/0005-2744(81)90298-9 |
0.38 |
|
| 1980 |
Elion GB, Benezra FM, Beardmore TD, Kelley WN. Studies with allopurinol in patients with impaired renal function. Advances in Experimental Medicine and Biology. 122: 263-7. PMID 7424645 DOI: 10.1007/978-1-4615-9140-5_43 |
0.313 |
|
| 1980 |
Daddona PE, Kelley WN. Analysis of normal and mutant forms of human adenosine deaminase - a review. Molecular and Cellular Biochemistry. 29: 91-101. PMID 6988697 DOI: 10.1007/Bf00220303 |
0.428 |
|
| 1980 |
Mitchell BS, Kelley WN. Purinogenic immunodeficiency diseases: clinical features and molecular mechanisms. Annals of Internal Medicine. 92: 826-31. PMID 6247948 DOI: 10.7326/0003-4819-92-6-826 |
0.39 |
|
| 1979 |
Mattes PM, Kelley WN. Measurement of the rates of synthesis and degradation of hypoxanthine-guanine phosphoribosyltransferase in human lymphoblasts. Advances in Experimental Medicine and Biology. 122: 289-94. PMID 546150 DOI: 10.1007/978-1-4684-8559-2_47 |
0.303 |
|
| 1979 |
Daddona PE, Kelley WN. Human adenosine deaminase: stoichiometry of the large form complex. Advances in Experimental Medicine and Biology. 122: 177-81. PMID 546143 DOI: 10.1007/978-1-4684-8559-2_30 |
0.342 |
|
| 1979 |
Daddona PE, Frohman MA, Kelley WN. Radioimmunochemical analysis of human erythrocyte adenosine deaminase. Advances in Experimental Medicine and Biology. 122: 157-62. PMID 546141 DOI: 10.1007/978-1-4684-8559-2_27 |
0.354 |
|
| 1979 |
Holden JA, Meredith GS, Kelley WN. Structural studies of human adenine phosphoribosyltransferase purified by affinity chromatography. Advances in Experimental Medicine and Biology. 122: 123-9. PMID 546139 DOI: 10.1007/978-1-4684-8559-2_22 |
0.414 |
|
| 1979 |
Daddona PE, Frohman MA, Kelley WN. Radioimmunochemical quantitation of human adenosine deaminase. The Journal of Clinical Investigation. 64: 798-803. PMID 468994 DOI: 10.1172/Jci109526 |
0.376 |
|
| 1979 |
Mitchell BS, Koller CA, Kelley WN. Treatment of acute lymphoblastic leukemia with the adenosine deaminase inhibitor 2'-deoxycoformycin. Advances in Experimental Medicine and Biology. 122: 347-50. PMID 317568 DOI: 10.1007/978-1-4684-8559-2_56 |
0.357 |
|
| 1979 |
Wilson JM, Mitchell BS, Kelley WN. Molecular mechanism(s) of deoxyribonucleoside toxicity in T-lymphoblasts. Advances in Experimental Medicine and Biology. 122: 265-70. PMID 317565 DOI: 10.1007/978-1-4684-8559-2_43 |
0.462 |
|
| 1979 |
Wilson JM, Mitchell BS, Daddona PE, Kelley WN. Purinogenic immunodeficiency diseases. Differential effects of deoxyadenosine and deoxyguanosine on DNA synthesis in human T lymphoblasts. The Journal of Clinical Investigation. 64: 1475-84. PMID 115901 DOI: 10.1172/Jci109606 |
0.419 |
|
| 1978 |
Arnold WJ, Kelley WN. Adenine phosphoribosyltransferase. Methods in Enzymology. 51: 568-74. PMID 692402 DOI: 10.1016/S0076-6879(78)51079-3 |
0.356 |
|
| 1977 |
Watts RW, Kelley WN, Rapado A, Scott JT, Seegmiller JE, de Vries A, Wyngaarden JB, Zöllner N. Panel discussion: hyperuricemia as a risk factor. Advances in Experimental Medicine and Biology. 76: 342-64. PMID 855760 DOI: 10.1007/978-1-4684-3285-5_51 |
0.463 |
|
| 1977 |
Daddona PE, Kelley WN. Purification of human erythrocyte adenosine deaminase. Advances in Experimental Medicine and Biology. 76: 223-34. PMID 855706 DOI: 10.1007/978-1-4613-4223-6_28 |
0.351 |
|
| 1977 |
Epstein J, Leyva A, Kelley WN, Littlefield JW. Mutagen-induced diploid human lymphoblast variants containing altered hypoxanthine guanine phosphoribosyl transferase. Somatic Cell Genetics. 3: 135-48. PMID 605378 DOI: 10.1007/Bf01551810 |
0.313 |
|
| 1977 |
Van der Weyden MB, Kelley WN. Adenosine deaminase deficiency and severe combined immunodeficiency disease. Life Sciences. 20: 1645-50. PMID 195170 DOI: 10.1016/0024-3205(77)90337-X |
0.331 |
|
| 1977 |
Van der Weyden MB, Kelley WN. Adenosine deaminase: characterization of the molecular heterogeneity of the enzyme in human tissue. Advances in Experimental Medicine and Biology. 76: 235-48. PMID 16447 DOI: 10.1007/978-1-4613-4223-6_29 |
0.341 |
|
| 1976 |
Fischer D, Van der Weyden MB, Snyderman R, Kelley WN. A role for adenosine deaminase in human monocyte maturation. The Journal of Clinical Investigation. 58: 399-407. PMID 956374 DOI: 10.1172/Jci108484 |
0.361 |
|
| 1976 |
Leyva A, Holmes EW, Kelley WN. Effect of 6-mercaptopurine on inosinic acid dehydrogenase in cultured human fibroblasts Biochemical Pharmacology. 25: 527-532. PMID 942489 DOI: 10.1016/0006-2952(76)90382-8 |
0.366 |
|
| 1975 |
Grobner W, Kelley WN. Effect of allopurinol and its metabolic derivatives on the configuration of human orotate phosphoribosyltransferase and orotidine 5'-phosphate decarboxylase Biochemical Pharmacology. 24: 379-384. PMID 1125044 DOI: 10.1016/0006-2952(75)90221-X |
0.338 |
|
| 1975 |
Kelley WN, Holmes EW, Van Der Weyden MB. Current concepts on the regulation of purine biosynthesis de novo in man Arthritis and Rheumatism. 18: 673-680. PMID 1106431 DOI: 10.1002/Art.1780180706 |
0.355 |
|
| 1975 |
Upchurch KS, Leyva A, Arnold WJ, Holmes EW, Kelley WN. Hypoxanthine phosphoribosyltransferase deficiency: association of reduced catalytic activity with reduced levels of immunologically detectable enzyme protein Proceedings of the National Academy of Sciences of the United States of America. 72: 4142-4146. PMID 1060094 DOI: 10.1073/Pnas.72.10.4142 |
0.382 |
|
| 1974 |
Arnold WJ, Jones RB, Kelley WN. Immunoadsorbent chromatography of hypoxanthine-guanine phosphoribosyltransferase Advances in Experimental Medicine and Biology. 41: 793-797. PMID 4857640 DOI: 10.1007/978-1-4757-1433-3_57 |
0.406 |
|
| 1974 |
Beardmore TD, Kelley WN. Effects of allopurinol and oxipurinol on pyrimidine biosynthesis in man Advances in Experimental Medicine and Biology. 41: 609-619. PMID 4832587 DOI: 10.1007/978-1-4757-1433-3_30 |
0.382 |
|
| 1974 |
van der Weyden MB, Buckley RH, Kelley WN. Molecular form of adenosine deaminase in severe combined immunodeficiency Biochemical and Biophysical Research Communications. 57: 590-595. PMID 4827825 DOI: 10.1016/0006-291X(74)90587-7 |
0.34 |
|
| 1974 |
Worthy TE, Grobner W, Kelley WN. Hereditary orotic aciduria: evidence for a structural gene mutation Proceedings of the National Academy of Sciences of the United States of America. 71: 3031-3035. PMID 4528586 DOI: 10.1073/Pnas.71.8.3031 |
0.415 |
|
| 1974 |
Holmes EW, Pehlke DM, Kelley WN. Human IMP dehydrogenase. Kinetics and regulatory properties Bba - Enzymology. 364: 209-217. PMID 4371273 DOI: 10.1016/0005-2744(74)90006-0 |
0.36 |
|
| 1974 |
Fox IH, Kelley WN. Observations of altered intracellular phosphoribosylpyrophosphate (PP-ribose-P) in human disease Advances in Experimental Medicine and Biology. 41: 471-478. PMID 4364979 DOI: 10.1007/978-1-4757-1433-3_12 |
0.356 |
|
| 1973 |
Kelley WN, Beardmore TD, Fox IH, Meade JC. Effect of allopurinol and oxipurinol on pyrimidine synthesis in cultured human fibroblasts. Biochemical Pharmacology. 20: 1471-8. PMID 5163085 DOI: 10.1016/0006-2952(71)90275-9 |
0.334 |
|
| 1973 |
Fox IH, Kelley WN. Adenine phosphoribosyltransferase deficiency: report of a second family Advances in Experimental Medicine and Biology. 41: 319-326. PMID 4791204 DOI: 10.1007/978-1-4684-3294-7_38 |
0.355 |
|
| 1973 |
Thomas CB, Arnold WJ, Kelley WN. Human adenine phosphoribosyltransferase: purification, subunit structure and substrate specificity Advances in Experimental Medicine and Biology. 41: 23-32. PMID 4791198 DOI: 10.1007/978-1-4684-3294-7_4 |
0.363 |
|
| 1973 |
Arnold WJ, Kelley WN. Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) deficiency: effect of dietary purines on enzyme activity Advances in Experimental Medicine and Biology. 41: 203-209. PMID 4791192 DOI: 10.1007/978-1-4684-3294-7_24 |
0.379 |
|
| 1973 |
Fox IH, Meade JC, Kelley WN. Adenine phosphoribosyltransferase deficiency in man. Report of a second family The American Journal of Medicine. 55: 614-620. PMID 4749203 DOI: 10.1016/0002-9343(73)90183-6 |
0.347 |
|
| 1973 |
Arnold WJ, Kelley WN. Dietary-induced variation of hypoxanthine-guanine phosphoribosyl transferase activity in patients with the Lesch-Nyhan syndrome Journal of Clinical Investigation. 52: 970-973. PMID 4693659 DOI: 10.1172/Jci107263 |
0.373 |
|
| 1973 |
Ramsdell CM, Kelley WN. The clinical significance of hypouricemia. Annals of Internal Medicine. 78: 239-42. PMID 4683752 DOI: 10.7326/0003-4819-78-2-239 |
0.329 |
|
| 1973 |
Kelley WN, Grobner W, Holmes E. Current concepts in the pathogenesis of hyperuricemia Metabolism. 22: 939-959. PMID 4575817 DOI: 10.1016/0026-0495(73)90066-8 |
0.369 |
|
| 1973 |
Fox IH, Kelley WN. Human phosphoribosylpyrophosphate (PP-ribose-P) synthetase: properties and regulation Advances in Experimental Medicine and Biology. 41: 79-86. PMID 4364692 DOI: 10.1007/978-1-4684-3294-7_10 |
0.325 |
|
| 1973 |
Holmes EW, Wyngaarden JB, Kelley WN. Human glltamine phosphoribosylpyrophosphate (PP-ribose-P) amidotransferase: kinetic, regulation and configurational changes Advances in Experimental Medicine and Biology. 41: 43-53. PMID 4364690 DOI: 10.1007/978-1-4684-3294-7_6 |
0.31 |
|
| 1973 |
McDonald JA, Kelley WN. Hypoxanthine-guanine phosphoribosyltransferase deficiency: altered kinetic properties of a specific mutant form of the enzyme Advances in Experimental Medicine and Biology. 41: 167-175. PMID 4364686 DOI: 10.1007/978-1-4684-3294-7_20 |
0.426 |
|
| 1973 |
Arnold WJ, Lamb RV, Kelley WN. Human hypoxanthine-guanine phosphoribosyltransferase (HGPRT): purification and properties Advances in Experimental Medicine and Biology. 41: 5-14. PMID 4208686 DOI: 10.1007/978-1-4684-3294-7_1 |
0.405 |
|
| 1973 |
Arnold WJ, Kelley WN. Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) deficiency: immunologic studies on the mutant enzyme Advances in Experimental Medicine and Biology. 41: 177-185. PMID 4208683 DOI: 10.1007/978-1-4684-3294-7_21 |
0.395 |
|
| 1972 |
Beardmore TD, Cashman JS, Kelley WN. Mechanism of allopurinol-mediated increase in enzyme activity in man. The Journal of Clinical Investigation. 51: 1823-32. PMID 5032526 DOI: 10.1172/Jci106984 |
0.382 |
|
| 1972 |
Pehlke DM, McDonald JA, Holmes EW, Kelley WN. Inosinic acid dehydrogenase activity in the Lesch-Nyhan syndrome. The Journal of Clinical Investigation. 51: 1398-404. PMID 5024037 DOI: 10.1172/Jci106935 |
0.398 |
|
| 1972 |
Arnold WJ, Meade JC, Kelley WN. Hypoxanthine-guanine phosphoribosyltransferase: characteristics of the mutant enzyme in erythrocytes from patients with the Lesch-Nyhan syndrome Journal of Clinical Investigation. 51: 1805-1812. PMID 4624352 DOI: 10.1172/Jci106982 |
0.418 |
|
| 1972 |
McDonald JA, Kelley WN. Lesch-Nyhan syndrome: Absence of the mutant enzyme in erythrocytes of a heterozygote for both normal and mutant hypoxanthine-guanine phosphoribosyl transferase Biochemical Genetics. 6: 21-26. PMID 4354247 DOI: 10.1007/Bf00485961 |
0.408 |
|
| 1972 |
Kelley WN. Biochemistry of the X-Linked Uric Aciduria—Enzyme Defect and Its Genetic Variants Archives of Internal Medicine. 130: 199. DOI: 10.1001/Archinte.1972.03650020029006 |
0.387 |
|
| 1971 |
McDonald JA, Kelley WN. Lesch-Nyhan syndrome: Altered kinetic properties of mutant enzyme Science. 171: 689-691. PMID 4322125 DOI: 10.1126/Science.171.3972.689 |
0.426 |
|
| 1971 |
Beardmore TD, Kelley WN. Mechanism of allopurinol-mediated inhibition of pyrimidine biosynthesis. Journal of Laboratory and Clinical Medicine. 78: 696-704. DOI: 10.5555/Uri:Pii:0022214371901405 |
0.362 |
|
| 1971 |
Beardmore TD, Kelley WN. Ultraviolet-Absorbing Compounds in Urine from Patients with Hereditary Disorders of Purine and Pyrimidine Metabolism Clinical Chemistry. 17: 795-801. DOI: 10.1093/Clinchem/17.8.795 |
0.313 |
|
| 1970 |
Kelley WN, Beardmore TD. Allopurinol: alteration in pyrimidine metabolism in man. Science. 169: 388-390. PMID 5450375 DOI: 10.1126/Science.169.3943.388 |
0.356 |
|
| 1970 |
Kelley WN, Wyngaarden JB. Effects of allopurinol and oxipurinol on purine synthesis in cultured human cells. The Journal of Clinical Investigation. 49: 602-9. PMID 5415686 DOI: 10.1172/Jci106271 |
0.322 |
|
| 1970 |
Kelley WN, Greene ML, Fox IH, Rosenbloom FM, Levy RI, Seegmiller JE. Effects of orotic acid on purine and lipoprotein metabolism in man. Metabolism: Clinical and Experimental. 19: 1025-35. PMID 4321643 DOI: 10.1016/0026-0495(70)90026-0 |
0.544 |
|
| 1970 |
Fox IH, Wyngaarden JB, Kelley WN. Depletion of erythrocyte phosphoribosylpyrophosphate in man. The New England Journal of Medicine. 283: 1177-82. PMID 4319625 DOI: 10.1056/Nejm197011262832201 |
0.31 |
|
| 1970 |
Kelley WN, Fox IH, Wyngaarden JB. Regulation of purine biosynthesis in cultured human cells. I. Effects of orotic acid. Biochimica Et Biophysica Acta. 215: 512-6. PMID 4319218 DOI: 10.1016/0304-4165(70)90101-7 |
0.366 |
|
| 1970 |
Kelley WN, Wyngaarden JB. Effect of Dietary Purine Restriction, Allupurinol, and Oxipurinol on Urinary Excretion of Ultraviolet-Absorbing Compounds Clinical Chemistry. 16: 707-713. DOI: 10.1093/Clinchem/16.8.707 |
0.309 |
|
| 1969 |
Henderson JF, Kelley WN, Rosenbloom FM, Seegmiller JE. Inheritance of purine phosphoribosyltransferases in man. American Journal of Human Genetics. 21: 61-70. PMID 5763607 |
0.464 |
|
| 1969 |
Kelley WN, Greene ML, Rosenbloom FM, Henderson JF, Seegmiller JE. Hypoxanthine-guanine phosphoribosyltransferase deficiency in gout. Annals of Internal Medicine. 70: 155-206. PMID 4884382 DOI: 10.7326/0003-4819-70-1-155 |
0.546 |
|
| 1968 |
Kelley WN, Levy RI, Rosenbloom FM, Henderson JF, Seegmiller JE. Adenine phosphoribosyltransferase deficiency: a previously undescribed genetic defect in man. The Journal of Clinical Investigation. 47: 2281-9. PMID 5676523 DOI: 10.1172/Jci105913 |
0.616 |
|
| 1968 |
Henderson JF, Miller HR, Kelley WN, Rosenbloom FM, Seegmiller JE. Kinetic studies of mutant human erythrocyte adenine phosphoribosyltransferases. Canadian Journal of Biochemistry. 46: 703-6. PMID 5665447 DOI: 10.1139/O68-108 |
0.57 |
|
| 1968 |
Henderson JF, Rosenbloom FM, Kelley WN, Seegmiller JE. Variations in purine metabolism of cultured skin fibroblasts from patients with gout. The Journal of Clinical Investigation. 47: 1511-6. PMID 5658584 DOI: 10.1172/Jci105844 |
0.539 |
|
| 1968 |
Henderson JF, Brox LW, Kelley WN, Rosenbloom FM, Seegmiller JE. Kinetic studies of hypoxanthine-guanine phosphoribosyltransferase. The Journal of Biological Chemistry. 243: 2514-22. PMID 5651638 |
0.417 |
|
| 1968 |
Rosenbloom FM, Henderson JF, Caldwell IC, Kelley WN, Seegmiller JE. Biochemical bases of accelerated purine biosynthesis de novo in human fibroblasts lacking hypoxanthine-guanine phosphoribosyltransferase. The Journal of Biological Chemistry. 243: 1166-73. PMID 5650894 |
0.466 |
|
| 1968 |
Kelley WN, Rosenbloom FM, Miller J, Seegmiller JE. An enzymatic basis for variation in response to allopurinol. Hypoxanthine-guanine phosphoribosyltransferase deficiency. The New England Journal of Medicine. 278: 287-93. PMID 5638346 DOI: 10.1056/NEJM196802082780601 |
0.439 |
|
| 1968 |
Kelley WN, Rosenbloom FM, Seegmiller JE, Howell RR. Excessive production of uric acid in type I glycogen storage disease. The Journal of Pediatrics. 72: 488-96. PMID 5239290 DOI: 10.1016/S0022-3476(68)80339-7 |
0.534 |
|
| 1967 |
Kelley WN, Rosenbloom FM, Seegmiller JE. The effects of azathioprine (imuran) on purine synthesis in clinical disorders of purine metabolism. The Journal of Clinical Investigation. 46: 1518-29. PMID 16695929 DOI: 10.1172/Jci105643 |
0.568 |
|
| 1967 |
Rosenbloom FM, Kelley WN, Miller J, Henderson JF, Seegmiller JE. Inherited disorder of purine metabolism. Correlation between central nervous system dysfunction and biochemical defects. Jama. 202: 175-7. PMID 6072350 DOI: 10.1001/Jama.1967.03130160049007 |
0.555 |
|
| 1967 |
Kelley WN, Rosenbloom FM, Henderson JF, Seegmiller JE. Xanthine phosphoribosyltransferase in man: relationship to hypoxanthine-guanine phosphoribosyltransferase. Biochemical and Biophysical Research Communications. 28: 340-5. PMID 6055161 DOI: 10.1016/0006-291X(67)90315-4 |
0.466 |
|
| 1967 |
Seegmiller JE, Rosenbloom FM, Kelley WN. Enzyme defect associated with a sex-linked human neurological disorder and excessive purine synthesis. Science (New York, N.Y.). 155: 1682-4. PMID 6020292 DOI: 10.1126/Science.155.3770.1682 |
0.582 |
|
| 1967 |
Kelley WN, Rosenbloom FM, Henderson JF, Seegmiller JE. A specific enzyme defect in gout associated with overproduction of uric acid. Proceedings of the National Academy of Sciences of the United States of America. 57: 1735-9. PMID 4291947 DOI: 10.1073/Pnas.57.6.1735 |
0.567 |
|
| 1967 |
Rosenbloom F, Kelley W, Henderson J, Seegmiller J. LYON HYPOTHESIS AND X-LINKED DISEASE The Lancet. 290: 305-306. DOI: 10.1016/S0140-6736(67)90137-7 |
0.458 |
|
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