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William N. Kelley, MD - Publications

Affiliations: 
University of Michigan at Ann Harbor University of Michigan, Ann Arbor, Ann Arbor, MI 
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Year Citation  Score
1996 Hillman AL, Brenner MK, Caplan AL, Carey J, Champey Y, Culver KW, Drummond MF, Freund DA, Holmes EW, Kelley WN, Kolata G, Levine MN, Levy E, Schondelmeyer SW, Velu T, et al. Gene therapy: socioeconomic and ethical issues. A roundtable discussion. Human Gene Therapy. 7: 1139-44. PMID 8773516 DOI: 10.1089/Hum.1996.7.9-1139  0.371
1991 Tarlé SA, Davidson BL, Wu VC, Zidar FJ, Seegmiller JE, Kelley WN, Palella TD. Determination of the mutations responsible for the Lesch-Nyhan syndrome in 17 subjects. Genomics. 10: 499-501. PMID 2071157 DOI: 10.1016/0888-7543(91)90341-B  0.657
1991 Davidson BL, Tarlé SA, Van Antwerp M, Gibbs DA, Watts RW, Kelley WN, Palella TD. Identification of 17 independent mutations responsible for human hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency. American Journal of Human Genetics. 48: 951-8. PMID 2018042  0.549
1989 Fujimori S, Davidson BL, Kelley WN, Palella TD. Identification of a single nucleotide change in the hypoxanthine-guanine phosphoribosyltransferase gene (HPRTYale) responsible for Lesch-Nyhan syndrome. The Journal of Clinical Investigation. 83: 11-3. PMID 2910902 DOI: 10.1172/Jci113846  0.559
1989 Davidson BL, Pashmforoush M, Kelley WN, Palella TD. Human hypoxanthine-guanine phosphoribosyltransferase deficiency. The molecular defect in a patient with gout (HPRTAshville). The Journal of Biological Chemistry. 264: 520-5. PMID 2909537  0.53
1989 Davidson BL, Tarlé SA, Palella TD, Kelley WN. Molecular basis of hypoxanthine-guanine phosphoribosyltransferase deficiency in ten subjects determined by direct sequencing of amplified transcripts. The Journal of Clinical Investigation. 84: 342-6. PMID 2738157 DOI: 10.1172/Jci114160  0.556
1989 Hidaka Y, Tarle SA, Kamatani N, Kelley WN, Palella TD. Human adenine phosphoribosyltransferase (APRT) deficiency: single mutant allele common to the Japanese. Advances in Experimental Medicine and Biology. 253: 43-9. PMID 2624223 DOI: 10.1007/978-1-4684-5673-8_7  0.391
1989 Davidson BL, Palella TD, Fujimori S, Kelley WN. Structural consequences of point mutations in nine human HPRT variants. Advances in Experimental Medicine and Biology. 253: 139-43. PMID 2624183 DOI: 10.1007/978-1-4684-5673-8_22  0.571
1989 Fujimori S, Davidson BL, Kelley WN, Palella TD. Lesch-Nyhan syndrome due to a single nucleotide change in the hypoxanthine-guanine phosphoribosyltransferase gene (HPRTYale). Advances in Experimental Medicine and Biology. 253: 135-8. PMID 2624182 DOI: 10.1007/978-1-4684-5673-8_21  0.547
1989 Palella TD, Silverman LJ, Homa FL, Levine M, Kelley WN. Transfer of human HPRT gene sequences into neuronal cells by a herpes simplex virus derived vector. Advances in Experimental Medicine and Biology. 253: 549-54. PMID 2560339 DOI: 10.1007/978-1-4684-5673-8_89  0.382
1989 Palella TD, Hidaka Y, Silverman LJ, Levine M, Glorioso J, Kelley WN. Expression of human HPRT mRNA in brains of mice infected with a recombinant herpes simplex virus-1 vector. Gene. 80: 137-44. PMID 2551779 DOI: 10.1016/0378-1119(89)90258-8  0.306
1988 Davidson BL, Pashmforoush M, Kelley WN, Palella TD. Genetic basis of hypoxanthine guanine phosphoribosyltransferase deficiency in a patient with the Lesch-Nyhan syndrome (HPRTFlint). Gene. 63: 331-6. PMID 3384338 DOI: 10.1016/0378-1119(88)90536-7  0.562
1988 Hidaka Y, Tarlé SA, Fujimori S, Kamatani N, Kelley WN, Palella TD. Human adenine phosphoribosyltransferase deficiency. Demonstration of a single mutant allele common to the Japanese. The Journal of Clinical Investigation. 81: 945-50. PMID 3343350 DOI: 10.1172/Jci113408  0.345
1988 Davidson BL, Palella TD, Kelley WN. Human hypoxanthine-guanine phosphoribosyltransferase: a single nucleotide substitution in cDNA clones isolated from a patient with Lesch-Nyhan syndrome (HPRTMidland). Gene. 68: 85-91. PMID 3265398 DOI: 10.1016/0378-1119(88)90601-4  0.572
1988 Davidson BL, Chin SJ, Wilson JM, Kelley WN, Palella TD. Hypoxanthine-guanine phosphoribosyltransferase. Genetic evidence for identical mutations in two partially deficient subjects. The Journal of Clinical Investigation. 82: 2164-7. PMID 3198771 DOI: 10.1172/Jci113839  0.598
1988 Fujimori S, Hidaka Y, Davidson BL, Palella TD, Kelley WN. Identification of a single nucleotide change in a mutant gene for hypoxanthine-guanine phosphoribosyltransferase (HPRT Ann Arbor). Human Genetics. 79: 39-43. PMID 2896620 DOI: 10.1007/Bf00291707  0.566
1988 Hidaka Y, Tarle SA, Kamatani N, Kelley WN, Palella TD. 55 Human Adenine Phosphoribosyltransferase (Aprt) Deficiency: A Single Mutant Allele Common To The Japanese Pediatric Research. 24: 120-120. DOI: 10.1203/00006450-198807000-00079  0.329
1988 Fujimori S, Davidson BL, Palella TD, Kelley WN. 38 LESCH-NYHAN SYNDROME DUE TO A SINGLE NUCLEOTIDE CHANGE IN THE HYPOXANTHINE-GUANIJE PHOSPHORIBOSYL-TRANSFERASE GENE (HPRT Yale ) Pediatric Research. 24: 117-117. DOI: 10.1203/00006450-198807000-00062  0.571
1988 Davidson BL, Palella TD, Fujimori S, Kelley WN. 27 Structural Consequences Of Point Mutations In Nine Human Hprt Variants Pediatric Research. 24: 115-115. DOI: 10.1203/00006450-198807000-00051  0.518
1987 Hidaka Y, Palella TD, O'Toole TE, Tarlé SA, Kelley WN. Human adenine phosphoribosyltransferase. Identification of allelic mutations at the nucleotide level as a cause of complete deficiency of the enzyme. The Journal of Clinical Investigation. 80: 1409-15. PMID 3680503 DOI: 10.1172/Jci113219  0.391
1987 Fox IH, Palella TD, Kelley WN. Hyperuricemia: a marker for cell energy crisis. The New England Journal of Medicine. 317: 111-2. PMID 3473283 DOI: 10.1056/Nejm198707093170209  0.325
1987 Silverman LJ, Kelley WN, Palella TD. Genetic analysis of human hypoxanthine-guanine phosphoribosyltransferase deficiency. Enzyme. 38: 36-44. PMID 2894305  0.366
1986 Wilson JM, Stout JT, Palella TD, Davidson BL, Kelley WN, Caskey CT. A molecular survey of hypoxanthine-guanine phosphoribosyltransferase deficiency in man. The Journal of Clinical Investigation. 77: 188-95. PMID 3944251 DOI: 10.1172/Jci112275  0.635
1986 Kelley WN, Searle JG, Wilson JM. HGPRT-deficiency--the molecular basis of the clinical syndromes. Verhandlungen Der Deutschen Gesellschaft FüR Innere Medizin. 92: 465-9. PMID 3811548 DOI: 10.1007/978-3-642-85459-0_91  0.52
1986 Wilson JM, O'Toole TE, Argos P, Shewach DS, Daddona PE, Kelley WN. Human adenine phosphoribosyltransferase. Complete amino acid sequence of the erythrocyte enzyme. The Journal of Biological Chemistry. 261: 13677-83. PMID 3531209  0.409
1985 Wilson JM, Kelley WN. Molecular genetics of hypoxanthine-guanine phosphoribosyltransferase deficiency in man. Archives of Internal Medicine. 145: 1895-1900. PMID 3899038 DOI: 10.1001/Archinte.1985.00360100165027  0.525
1985 Daddona PE, Orkin SH, Shewach DS, Kelley WN. cDNA and amino acid sequence of human adenosine deaminase. Annals of the New York Academy of Sciences. 451: 238-44. PMID 3878119 DOI: 10.1111/J.1749-6632.1985.Tb27114.X  0.453
1985 Daddona PE, Davidson BL, Perignon JL, Kelley WN. Genetic expression in partial adenosine deaminase deficiency. mRNA levels and protein turnover for the enzyme variants in human B-lymphoblast cell lines. The Journal of Biological Chemistry. 260: 3875-80. PMID 3871777  0.517
1985 Orkin SH, Goff SC, Kelley WN, Daddona PE. Transient expression of human adenosine deaminase cDNAs: identification of a nonfunctional clone resulting from a single amino acid substitution. Molecular and Cellular Biology. 5: 762-7. PMID 3838797 DOI: 10.1128/Mcb.5.4.762  0.416
1985 Davidson BJ, Palella TD, Wilson JM, Doddona PE, O'Toole T, Kelley WN. A MOLECULAR SURVEY OF HPRT DEFICIENCY: 48 Pediatric Research. 19: 751-751. DOI: 10.1203/00006450-198507000-00068  0.511
1985 Daddono PE, Orkin SH, Kelley WN. Expression Defects Of Mutant Human Adenosine Deaminase: 42 Pediatric Research. 19: 750-750. DOI: 10.1203/00006450-198507000-00062  0.434
1984 Wilson JM, Tarr GE, Kelley WN. The primary structure and posttranslational modification of human hypoxanthine-guanine phosphoribosyltransferase. Advances in Experimental Medicine and Biology. 165: 39-44. PMID 6720436 DOI: 10.1007/978-1-4757-0390-0_8  0.516
1984 Wilson JM, Baugher BW, Kelley WN. Hypoxanthine-guanine phosphoribosyltransferase in human lymphoblastoid cells: confirmation of four structural variants and demonstration of a new variant (HPRT Ann Arbor). Advances in Experimental Medicine and Biology. 165: 33-8. PMID 6720433 DOI: 10.1007/978-1-4757-0390-0_7  0.533
1984 Wilson JM, Daddona PE, Simmonds HA, Kelley WN. Genetic mechanism(s) responsible for a deficiency of adenine phosphoribosyltransferase in man. Advances in Experimental Medicine and Biology. 165: 385-9. PMID 6720407 DOI: 10.1007/978-1-4684-4553-4_76  0.506
1984 Wilson JM, Kelley WN. Human hypoxanthine-guanine phosphoribosyltransferase. Structural alteration in a dysfunctional enzyme variant (HPRTMunich) isolated from a patient with gout. The Journal of Biological Chemistry. 259: 27-30. PMID 6706936  0.467
1984 Kazmers IS, Dalke AP, Daddona PE, Kelley WN. Sensitivity of human T and B lymphoblasts to immunoregulatory drugs. Advances in Experimental Medicine and Biology. 165: 211-4. PMID 6609534 DOI: 10.1007/978-1-4757-0390-0_42  0.309
1984 Wilson JM, Kelley WN. Molecular genetics of the HPRT-deficiency syndromes. Hospital Practice (Office Ed.). 19: 81-9, 93-7, 100. PMID 6425346 DOI: 10.1080/21548331.1984.11702819  0.437
1983 Kelley WN, Wilson JM. Human hypoxanthine-guanine phosphoribosyltransferase: studies of the normal and five mutant forms of the enzyme. Transactions of the American Clinical and Climatological Association. 94: 91-9. PMID 7186238  0.432
1983 Wilson JM, Kelley WN. Molecular basis of hypoxanthine-guanine phosphoribosyltransferase deficiency in a patient with the Lesch-Nyhan syndrome. The Journal of Clinical Investigation. 71: 1331-5. PMID 6853716 DOI: 10.1172/Jci110884  0.529
1983 Wilson JM, Kobayashi R, Fox IH, Kelley WN. Human hypoxanthine-guanine phosphoribosyltransferase. The Journal of Biological Chemistry. 258: 6458-60. PMID 6853490  0.415
1983 O'Toole TE, Wilson JM, Gault MH, Kelley WN. Human adenine phosphoribosyltransferase: characterization from subjects with a deficiency of enzyme activity. Biochemical Genetics. 21: 1121-34. PMID 6670989 DOI: 10.1007/Bf00488464  0.49
1983 Wilson JM, Tarr GE, Kelley WN. Human hypoxanthine (guanine) phosphoribosyltransferase: an amino acid substitution in a mutant form of the enzyme isolated from a patient with gout. Proceedings of the National Academy of Sciences of the United States of America. 80: 870-3. PMID 6572373 DOI: 10.1073/Pnas.80.3.870  0.537
1983 Argos P, Hanei M, Wilson JM, Kelley WN. A possible nucleotide-binding domain in the tertiary fold of phosphoribosyltransferases. The Journal of Biological Chemistry. 258: 6450-7. PMID 6343377  0.357
1983 Wilson JM, Frossard P, Nussbaum RL, Caskey CT, Kelley WN. Human hypoxanthine-guanine phosphoribosyltransferase. Detection of a mutant allele by restriction endonuclease analysis. The Journal of Clinical Investigation. 72: 767-72. PMID 6309910 DOI: 10.1172/Jci111047  0.486
1983 Wilson JM, Young AB, Kelley WN. Hypoxanthine-guanine phosphoribosyltransferase deficiency. The molecular basis of the clinical syndromes. The New England Journal of Medicine. 309: 900-10. PMID 6136913 DOI: 10.1056/Nejm198310133091507  0.516
1982 Wilson JM, Landa LE, Kobayashi R, Kelley WN. Human hypoxanthine-guanine phosphoribosyltransferase. Tryptic peptides and post-translational modification of the erythrocyte enzyme. The Journal of Biological Chemistry. 257: 14830-4. PMID 7174669  0.328
1982 Rassin DK, Lloyd KG, Kelley WN, Fox I. Decreased amino acids in various brain areas of patients with Lesch-Nyhan syndrome. Neuropediatrics. 13: 130-4. PMID 7133331 DOI: 10.1055/S-2008-1059611  0.363
1982 Wilson JM, Tarr GE, Mahoney WC, Kelley WN. Human hypoxanthine-guanine phosphoribosyltransferase. Complete amino acid sequence of the erythrocyte enzyme. The Journal of Biological Chemistry. 257: 10978-85. PMID 7107641  0.399
1982 Wilson JM, Daddona PE, Otoadese T, Kelley WN. Adenine phosphoribosyltransferase in patients with disorders of purine and pyrimidine metabolism. The Journal of Laboratory and Clinical Medicine. 99: 163-74. PMID 7061917  0.428
1982 Wilson JM, Baugher BW, Mattes PM, Daddona PE, Kelley WN. Human hypoxanthine-guanine phosphoribosyltransferase. Demonstration of structural variants in lymphoblastoid cells derived from patients with a deficiency of the enzyme. The Journal of Clinical Investigation. 69: 706-15. PMID 7061709 DOI: 10.1172/Jci110499  0.532
1982 Wilson JM, Daddona PE, Simmonds HA, Van Acker KJ, Kelley WN. Human adenine phosphoribosyltransferase. Immunochemical quantitation and protein blot analysis of mutant forms of the enzyme. The Journal of Biological Chemistry. 257: 1508-15. PMID 7056730  0.465
1982 Daddona PE, Kelley WN. Control of adenosine deaminase levels in human lymphoblasts. Advances in Enzyme Regulation. 20: 153-63. PMID 6981287 DOI: 10.1016/0065-2571(82)90014-0  0.32
1981 Daddona PE, Frohman MA, Kelley WN. Radioimmunoassay of human adenosine deaminase. Methods in Enzymology. 74: 351-8. PMID 7321887 DOI: 10.1016/0076-6879(81)74025-4  0.322
1981 Wilson JM, Baugher BW, Landa L, Kelley WN. Human hypoxanthine-guanine phosphoribosyltransferase. Purification and characterization of mutant forms of the enzyme. The Journal of Biological Chemistry. 256: 10306-12. PMID 7287714  0.397
1981 Daddona PE, Kelley WN. Characteristics of an aminohydrolase distinct from adenosine deaminase in cultured human lymphoblasts. Biochimica Et Biophysica Acta. 658: 280-90. PMID 6972784 DOI: 10.1016/0005-2744(81)90298-9  0.38
1980 Elion GB, Benezra FM, Beardmore TD, Kelley WN. Studies with allopurinol in patients with impaired renal function. Advances in Experimental Medicine and Biology. 122: 263-7. PMID 7424645 DOI: 10.1007/978-1-4615-9140-5_43  0.313
1980 Daddona PE, Kelley WN. Analysis of normal and mutant forms of human adenosine deaminase - a review. Molecular and Cellular Biochemistry. 29: 91-101. PMID 6988697 DOI: 10.1007/Bf00220303  0.428
1980 Mitchell BS, Kelley WN. Purinogenic immunodeficiency diseases: clinical features and molecular mechanisms. Annals of Internal Medicine. 92: 826-31. PMID 6247948 DOI: 10.7326/0003-4819-92-6-826  0.39
1979 Mattes PM, Kelley WN. Measurement of the rates of synthesis and degradation of hypoxanthine-guanine phosphoribosyltransferase in human lymphoblasts. Advances in Experimental Medicine and Biology. 122: 289-94. PMID 546150 DOI: 10.1007/978-1-4684-8559-2_47  0.303
1979 Daddona PE, Kelley WN. Human adenosine deaminase: stoichiometry of the large form complex. Advances in Experimental Medicine and Biology. 122: 177-81. PMID 546143 DOI: 10.1007/978-1-4684-8559-2_30  0.342
1979 Daddona PE, Frohman MA, Kelley WN. Radioimmunochemical analysis of human erythrocyte adenosine deaminase. Advances in Experimental Medicine and Biology. 122: 157-62. PMID 546141 DOI: 10.1007/978-1-4684-8559-2_27  0.354
1979 Holden JA, Meredith GS, Kelley WN. Structural studies of human adenine phosphoribosyltransferase purified by affinity chromatography. Advances in Experimental Medicine and Biology. 122: 123-9. PMID 546139 DOI: 10.1007/978-1-4684-8559-2_22  0.414
1979 Daddona PE, Frohman MA, Kelley WN. Radioimmunochemical quantitation of human adenosine deaminase. The Journal of Clinical Investigation. 64: 798-803. PMID 468994 DOI: 10.1172/Jci109526  0.376
1979 Mitchell BS, Koller CA, Kelley WN. Treatment of acute lymphoblastic leukemia with the adenosine deaminase inhibitor 2'-deoxycoformycin. Advances in Experimental Medicine and Biology. 122: 347-50. PMID 317568 DOI: 10.1007/978-1-4684-8559-2_56  0.357
1979 Wilson JM, Mitchell BS, Kelley WN. Molecular mechanism(s) of deoxyribonucleoside toxicity in T-lymphoblasts. Advances in Experimental Medicine and Biology. 122: 265-70. PMID 317565 DOI: 10.1007/978-1-4684-8559-2_43  0.462
1979 Wilson JM, Mitchell BS, Daddona PE, Kelley WN. Purinogenic immunodeficiency diseases. Differential effects of deoxyadenosine and deoxyguanosine on DNA synthesis in human T lymphoblasts. The Journal of Clinical Investigation. 64: 1475-84. PMID 115901 DOI: 10.1172/Jci109606  0.419
1978 Arnold WJ, Kelley WN. Adenine phosphoribosyltransferase. Methods in Enzymology. 51: 568-74. PMID 692402 DOI: 10.1016/S0076-6879(78)51079-3  0.356
1977 Watts RW, Kelley WN, Rapado A, Scott JT, Seegmiller JE, de Vries A, Wyngaarden JB, Zöllner N. Panel discussion: hyperuricemia as a risk factor. Advances in Experimental Medicine and Biology. 76: 342-64. PMID 855760 DOI: 10.1007/978-1-4684-3285-5_51  0.463
1977 Daddona PE, Kelley WN. Purification of human erythrocyte adenosine deaminase. Advances in Experimental Medicine and Biology. 76: 223-34. PMID 855706 DOI: 10.1007/978-1-4613-4223-6_28  0.351
1977 Epstein J, Leyva A, Kelley WN, Littlefield JW. Mutagen-induced diploid human lymphoblast variants containing altered hypoxanthine guanine phosphoribosyl transferase. Somatic Cell Genetics. 3: 135-48. PMID 605378 DOI: 10.1007/Bf01551810  0.313
1977 Van der Weyden MB, Kelley WN. Adenosine deaminase deficiency and severe combined immunodeficiency disease. Life Sciences. 20: 1645-50. PMID 195170 DOI: 10.1016/0024-3205(77)90337-X  0.331
1977 Van der Weyden MB, Kelley WN. Adenosine deaminase: characterization of the molecular heterogeneity of the enzyme in human tissue. Advances in Experimental Medicine and Biology. 76: 235-48. PMID 16447 DOI: 10.1007/978-1-4613-4223-6_29  0.341
1976 Fischer D, Van der Weyden MB, Snyderman R, Kelley WN. A role for adenosine deaminase in human monocyte maturation. The Journal of Clinical Investigation. 58: 399-407. PMID 956374 DOI: 10.1172/Jci108484  0.361
1976 Leyva A, Holmes EW, Kelley WN. Effect of 6-mercaptopurine on inosinic acid dehydrogenase in cultured human fibroblasts Biochemical Pharmacology. 25: 527-532. PMID 942489 DOI: 10.1016/0006-2952(76)90382-8  0.366
1975 Grobner W, Kelley WN. Effect of allopurinol and its metabolic derivatives on the configuration of human orotate phosphoribosyltransferase and orotidine 5'-phosphate decarboxylase Biochemical Pharmacology. 24: 379-384. PMID 1125044 DOI: 10.1016/0006-2952(75)90221-X  0.338
1975 Kelley WN, Holmes EW, Van Der Weyden MB. Current concepts on the regulation of purine biosynthesis de novo in man Arthritis and Rheumatism. 18: 673-680. PMID 1106431 DOI: 10.1002/Art.1780180706  0.355
1975 Upchurch KS, Leyva A, Arnold WJ, Holmes EW, Kelley WN. Hypoxanthine phosphoribosyltransferase deficiency: association of reduced catalytic activity with reduced levels of immunologically detectable enzyme protein Proceedings of the National Academy of Sciences of the United States of America. 72: 4142-4146. PMID 1060094 DOI: 10.1073/Pnas.72.10.4142  0.382
1974 Arnold WJ, Jones RB, Kelley WN. Immunoadsorbent chromatography of hypoxanthine-guanine phosphoribosyltransferase Advances in Experimental Medicine and Biology. 41: 793-797. PMID 4857640 DOI: 10.1007/978-1-4757-1433-3_57  0.406
1974 Beardmore TD, Kelley WN. Effects of allopurinol and oxipurinol on pyrimidine biosynthesis in man Advances in Experimental Medicine and Biology. 41: 609-619. PMID 4832587 DOI: 10.1007/978-1-4757-1433-3_30  0.382
1974 van der Weyden MB, Buckley RH, Kelley WN. Molecular form of adenosine deaminase in severe combined immunodeficiency Biochemical and Biophysical Research Communications. 57: 590-595. PMID 4827825 DOI: 10.1016/0006-291X(74)90587-7  0.34
1974 Worthy TE, Grobner W, Kelley WN. Hereditary orotic aciduria: evidence for a structural gene mutation Proceedings of the National Academy of Sciences of the United States of America. 71: 3031-3035. PMID 4528586 DOI: 10.1073/Pnas.71.8.3031  0.415
1974 Holmes EW, Pehlke DM, Kelley WN. Human IMP dehydrogenase. Kinetics and regulatory properties Bba - Enzymology. 364: 209-217. PMID 4371273 DOI: 10.1016/0005-2744(74)90006-0  0.36
1974 Fox IH, Kelley WN. Observations of altered intracellular phosphoribosylpyrophosphate (PP-ribose-P) in human disease Advances in Experimental Medicine and Biology. 41: 471-478. PMID 4364979 DOI: 10.1007/978-1-4757-1433-3_12  0.356
1973 Kelley WN, Beardmore TD, Fox IH, Meade JC. Effect of allopurinol and oxipurinol on pyrimidine synthesis in cultured human fibroblasts. Biochemical Pharmacology. 20: 1471-8. PMID 5163085 DOI: 10.1016/0006-2952(71)90275-9  0.334
1973 Fox IH, Kelley WN. Adenine phosphoribosyltransferase deficiency: report of a second family Advances in Experimental Medicine and Biology. 41: 319-326. PMID 4791204 DOI: 10.1007/978-1-4684-3294-7_38  0.355
1973 Thomas CB, Arnold WJ, Kelley WN. Human adenine phosphoribosyltransferase: purification, subunit structure and substrate specificity Advances in Experimental Medicine and Biology. 41: 23-32. PMID 4791198 DOI: 10.1007/978-1-4684-3294-7_4  0.363
1973 Arnold WJ, Kelley WN. Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) deficiency: effect of dietary purines on enzyme activity Advances in Experimental Medicine and Biology. 41: 203-209. PMID 4791192 DOI: 10.1007/978-1-4684-3294-7_24  0.379
1973 Fox IH, Meade JC, Kelley WN. Adenine phosphoribosyltransferase deficiency in man. Report of a second family The American Journal of Medicine. 55: 614-620. PMID 4749203 DOI: 10.1016/0002-9343(73)90183-6  0.347
1973 Arnold WJ, Kelley WN. Dietary-induced variation of hypoxanthine-guanine phosphoribosyl transferase activity in patients with the Lesch-Nyhan syndrome Journal of Clinical Investigation. 52: 970-973. PMID 4693659 DOI: 10.1172/Jci107263  0.373
1973 Ramsdell CM, Kelley WN. The clinical significance of hypouricemia. Annals of Internal Medicine. 78: 239-42. PMID 4683752 DOI: 10.7326/0003-4819-78-2-239  0.329
1973 Kelley WN, Grobner W, Holmes E. Current concepts in the pathogenesis of hyperuricemia Metabolism. 22: 939-959. PMID 4575817 DOI: 10.1016/0026-0495(73)90066-8  0.369
1973 Fox IH, Kelley WN. Human phosphoribosylpyrophosphate (PP-ribose-P) synthetase: properties and regulation Advances in Experimental Medicine and Biology. 41: 79-86. PMID 4364692 DOI: 10.1007/978-1-4684-3294-7_10  0.325
1973 Holmes EW, Wyngaarden JB, Kelley WN. Human glltamine phosphoribosylpyrophosphate (PP-ribose-P) amidotransferase: kinetic, regulation and configurational changes Advances in Experimental Medicine and Biology. 41: 43-53. PMID 4364690 DOI: 10.1007/978-1-4684-3294-7_6  0.31
1973 McDonald JA, Kelley WN. Hypoxanthine-guanine phosphoribosyltransferase deficiency: altered kinetic properties of a specific mutant form of the enzyme Advances in Experimental Medicine and Biology. 41: 167-175. PMID 4364686 DOI: 10.1007/978-1-4684-3294-7_20  0.426
1973 Arnold WJ, Lamb RV, Kelley WN. Human hypoxanthine-guanine phosphoribosyltransferase (HGPRT): purification and properties Advances in Experimental Medicine and Biology. 41: 5-14. PMID 4208686 DOI: 10.1007/978-1-4684-3294-7_1  0.405
1973 Arnold WJ, Kelley WN. Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) deficiency: immunologic studies on the mutant enzyme Advances in Experimental Medicine and Biology. 41: 177-185. PMID 4208683 DOI: 10.1007/978-1-4684-3294-7_21  0.395
1972 Beardmore TD, Cashman JS, Kelley WN. Mechanism of allopurinol-mediated increase in enzyme activity in man. The Journal of Clinical Investigation. 51: 1823-32. PMID 5032526 DOI: 10.1172/Jci106984  0.382
1972 Pehlke DM, McDonald JA, Holmes EW, Kelley WN. Inosinic acid dehydrogenase activity in the Lesch-Nyhan syndrome. The Journal of Clinical Investigation. 51: 1398-404. PMID 5024037 DOI: 10.1172/Jci106935  0.398
1972 Arnold WJ, Meade JC, Kelley WN. Hypoxanthine-guanine phosphoribosyltransferase: characteristics of the mutant enzyme in erythrocytes from patients with the Lesch-Nyhan syndrome Journal of Clinical Investigation. 51: 1805-1812. PMID 4624352 DOI: 10.1172/Jci106982  0.418
1972 McDonald JA, Kelley WN. Lesch-Nyhan syndrome: Absence of the mutant enzyme in erythrocytes of a heterozygote for both normal and mutant hypoxanthine-guanine phosphoribosyl transferase Biochemical Genetics. 6: 21-26. PMID 4354247 DOI: 10.1007/Bf00485961  0.408
1972 Kelley WN. Biochemistry of the X-Linked Uric Aciduria—Enzyme Defect and Its Genetic Variants Archives of Internal Medicine. 130: 199. DOI: 10.1001/Archinte.1972.03650020029006  0.387
1971 McDonald JA, Kelley WN. Lesch-Nyhan syndrome: Altered kinetic properties of mutant enzyme Science. 171: 689-691. PMID 4322125 DOI: 10.1126/Science.171.3972.689  0.426
1971 Beardmore TD, Kelley WN. Mechanism of allopurinol-mediated inhibition of pyrimidine biosynthesis. Journal of Laboratory and Clinical Medicine. 78: 696-704. DOI: 10.5555/Uri:Pii:0022214371901405  0.362
1971 Beardmore TD, Kelley WN. Ultraviolet-Absorbing Compounds in Urine from Patients with Hereditary Disorders of Purine and Pyrimidine Metabolism Clinical Chemistry. 17: 795-801. DOI: 10.1093/Clinchem/17.8.795  0.313
1970 Kelley WN, Beardmore TD. Allopurinol: alteration in pyrimidine metabolism in man. Science. 169: 388-390. PMID 5450375 DOI: 10.1126/Science.169.3943.388  0.356
1970 Kelley WN, Wyngaarden JB. Effects of allopurinol and oxipurinol on purine synthesis in cultured human cells. The Journal of Clinical Investigation. 49: 602-9. PMID 5415686 DOI: 10.1172/Jci106271  0.322
1970 Kelley WN, Greene ML, Fox IH, Rosenbloom FM, Levy RI, Seegmiller JE. Effects of orotic acid on purine and lipoprotein metabolism in man. Metabolism: Clinical and Experimental. 19: 1025-35. PMID 4321643 DOI: 10.1016/0026-0495(70)90026-0  0.544
1970 Fox IH, Wyngaarden JB, Kelley WN. Depletion of erythrocyte phosphoribosylpyrophosphate in man. The New England Journal of Medicine. 283: 1177-82. PMID 4319625 DOI: 10.1056/Nejm197011262832201  0.31
1970 Kelley WN, Fox IH, Wyngaarden JB. Regulation of purine biosynthesis in cultured human cells. I. Effects of orotic acid. Biochimica Et Biophysica Acta. 215: 512-6. PMID 4319218 DOI: 10.1016/0304-4165(70)90101-7  0.365
1970 Kelley WN, Wyngaarden JB. Effect of Dietary Purine Restriction, Allupurinol, and Oxipurinol on Urinary Excretion of Ultraviolet-Absorbing Compounds Clinical Chemistry. 16: 707-713. DOI: 10.1093/Clinchem/16.8.707  0.309
1969 Henderson JF, Kelley WN, Rosenbloom FM, Seegmiller JE. Inheritance of purine phosphoribosyltransferases in man. American Journal of Human Genetics. 21: 61-70. PMID 5763607  0.464
1969 Kelley WN, Greene ML, Rosenbloom FM, Henderson JF, Seegmiller JE. Hypoxanthine-guanine phosphoribosyltransferase deficiency in gout. Annals of Internal Medicine. 70: 155-206. PMID 4884382 DOI: 10.7326/0003-4819-70-1-155  0.546
1968 Kelley WN, Levy RI, Rosenbloom FM, Henderson JF, Seegmiller JE. Adenine phosphoribosyltransferase deficiency: a previously undescribed genetic defect in man. The Journal of Clinical Investigation. 47: 2281-9. PMID 5676523 DOI: 10.1172/Jci105913  0.616
1968 Henderson JF, Miller HR, Kelley WN, Rosenbloom FM, Seegmiller JE. Kinetic studies of mutant human erythrocyte adenine phosphoribosyltransferases. Canadian Journal of Biochemistry. 46: 703-6. PMID 5665447 DOI: 10.1139/O68-108  0.57
1968 Henderson JF, Rosenbloom FM, Kelley WN, Seegmiller JE. Variations in purine metabolism of cultured skin fibroblasts from patients with gout. The Journal of Clinical Investigation. 47: 1511-6. PMID 5658584 DOI: 10.1172/Jci105844  0.539
1968 Henderson JF, Brox LW, Kelley WN, Rosenbloom FM, Seegmiller JE. Kinetic studies of hypoxanthine-guanine phosphoribosyltransferase. The Journal of Biological Chemistry. 243: 2514-22. PMID 5651638  0.417
1968 Rosenbloom FM, Henderson JF, Caldwell IC, Kelley WN, Seegmiller JE. Biochemical bases of accelerated purine biosynthesis de novo in human fibroblasts lacking hypoxanthine-guanine phosphoribosyltransferase. The Journal of Biological Chemistry. 243: 1166-73. PMID 5650894  0.466
1968 Kelley WN, Rosenbloom FM, Miller J, Seegmiller JE. An enzymatic basis for variation in response to allopurinol. Hypoxanthine-guanine phosphoribosyltransferase deficiency. The New England Journal of Medicine. 278: 287-93. PMID 5638346 DOI: 10.1056/NEJM196802082780601  0.439
1968 Kelley WN, Rosenbloom FM, Seegmiller JE, Howell RR. Excessive production of uric acid in type I glycogen storage disease. The Journal of Pediatrics. 72: 488-96. PMID 5239290 DOI: 10.1016/S0022-3476(68)80339-7  0.534
1967 Kelley WN, Rosenbloom FM, Seegmiller JE. The effects of azathioprine (imuran) on purine synthesis in clinical disorders of purine metabolism. The Journal of Clinical Investigation. 46: 1518-29. PMID 16695929 DOI: 10.1172/Jci105643  0.568
1967 Rosenbloom FM, Kelley WN, Miller J, Henderson JF, Seegmiller JE. Inherited disorder of purine metabolism. Correlation between central nervous system dysfunction and biochemical defects. Jama. 202: 175-7. PMID 6072350 DOI: 10.1001/Jama.1967.03130160049007  0.555
1967 Kelley WN, Rosenbloom FM, Henderson JF, Seegmiller JE. Xanthine phosphoribosyltransferase in man: relationship to hypoxanthine-guanine phosphoribosyltransferase. Biochemical and Biophysical Research Communications. 28: 340-5. PMID 6055161 DOI: 10.1016/0006-291X(67)90315-4  0.466
1967 Seegmiller JE, Rosenbloom FM, Kelley WN. Enzyme defect associated with a sex-linked human neurological disorder and excessive purine synthesis. Science (New York, N.Y.). 155: 1682-4. PMID 6020292 DOI: 10.1126/Science.155.3770.1682  0.582
1967 Kelley WN, Rosenbloom FM, Henderson JF, Seegmiller JE. A specific enzyme defect in gout associated with overproduction of uric acid. Proceedings of the National Academy of Sciences of the United States of America. 57: 1735-9. PMID 4291947 DOI: 10.1073/Pnas.57.6.1735  0.567
1967 Rosenbloom F, Kelley W, Henderson J, Seegmiller J. LYON HYPOTHESIS AND X-LINKED DISEASE The Lancet. 290: 305-306. DOI: 10.1016/S0140-6736(67)90137-7  0.458
Low-probability matches (unlikely to be authored by this person)
1972 Postlethwaite AE, Kelley WN. Studies on the mechanism of ethambutol-induced hyperuricemia. Arthritis & Rheumatism. 15: 403-409. PMID 5046470 DOI: 10.1002/Art.1780150411  0.299
1970 Feldman JM, Kelley WN, Lebovitz HE. Inhibition of glucose oxidase paper tests by reducing metabolites. Diabetes. 19: 337-43. PMID 5443435 DOI: 10.2337/Diab.19.5.337  0.298
1974 Rockson S, Stone R, Van Der Weyden M, Kelley WN. Lesch Nyhan syndrome: evidence for abnormal adrenergic function Science. 186: 934-935. PMID 4469689 DOI: 10.1126/Science.186.4167.934  0.297
1988 Palella TD, Silverman LJ, Schroll CT, Homa FL, Levine M, Kelley WN. Herpes simplex virus-mediated human hypoxanthine-guanine phosphoribosyltransferase gene transfer into neuronal cells. Molecular and Cellular Biology. 8: 457-60. PMID 2827006 DOI: 10.1128/Mcb.8.1.457  0.297
1981 Lloyd KG, Hornykiewicz O, Davidson L, Shannak K, Farley I, Goldstein M, Shibuya M, Kelley WN, Fox IH. Biochemical evidence of dysfunction of brain neurotransmitters in the Lesch-Nyhan syndrome. The New England Journal of Medicine. 305: 1106-11. PMID 6117011 DOI: 10.1056/Nejm198111053051902  0.296
1974 Holmes EW, Kelley WN. Reevaluation of the pyrazinamide suppression test Advances in Experimental Medicine and Biology. 41: 739-744. PMID 4832603 DOI: 10.1007/978-1-4757-1433-3_48  0.294
1972 Postlethwaite AE, Kelley WN. Radiocontrast agents and aspirin. Jama. 219: 1479. PMID 5066914 DOI: 10.1001/Jama.1972.03190370069027  0.292
1979 Fox IH, Kelley WN. Management of gout. Jama. 242: 361-4. PMID 448944 DOI: 10.1001/Jama.1979.03300040043027  0.29
1974 Holmes EW, Mason DH, Goldstein LI, Blount RE, Kelley WN. Xanthine oxidase deficiency: studies of a previously unreported case. Clinical Chemistry. 20: 1076-9. PMID 4369449 DOI: 10.1093/Clinchem/20.8.1076  0.289
1981 Kazmers IS, Mitchell BS, Dadonna PE, Wotring LL, Townsend LB, Kelley WN. Inhibition of purine nucleoside phosphorylase by 8-aminoguanosine: selective toxicity for T lymphoblasts. Science (New York, N.Y.). 214: 1137-9. PMID 6795718 DOI: 10.1126/Science.6795718  0.288
1978 Kelton J, Kelley WN, Holmes EW. A rapid method for the diagnosis of acute uric acid nephropathy. Archives of Internal Medicine. 138: 612-5. PMID 637642 DOI: 10.1001/Archinte.1978.03630280074023  0.288
1970 Beardmore T, Fox I, Kelley W. Effect of allopurinol on pyrimidine metabolism in the Lesch-Nyhan syndrome. The Lancet. 296: 830-831. PMID 4196060 DOI: 10.1016/S0140-6736(70)91504-7  0.286
1978 Fox IH, Kelley WN. The role of adenosine and 2'-deoxyadenosine in mammalian cells. Annual Review of Biochemistry. 47: 655-86. PMID 209731 DOI: 10.1146/Annurev.Bi.47.070178.003255  0.284
1973 Beardmore TD, Meade JC, Kelley WN. Increased activity of two enzymes of pyrimidine biosynthesis de novo in erythrocytes from patients with the Lesch-Nyhan syndrome The Journal of Laboratory and Clinical Medicine. 81: 43-52. PMID 4344924  0.283
1973 Fox IH, Kelley WN. Pharmacological alterations of intracellular phosphoribosylpyrophosphate (PP-ribose-P) in human tissues Advances in Experimental Medicine and Biology. 41: 93-99. PMID 4275443 DOI: 10.1007/978-1-4684-3294-7_12  0.281
1974 Fox IH, Kelley WN. Studies on the mechanism of fructose-induced hyperuricemia in man Advances in Experimental Medicine and Biology. 41: 463-470. PMID 4364978 DOI: 10.1016/0026-0495(72)90120-5  0.281
1973 Kelley WN, Arnold WJ. Human hypoxanthine guanine phosphoribosyltransferase: studies on the normal and mutant forms of the enzyme Federation Proceedings. 32: 1656-1659. PMID 4710877  0.28
1978 Daddona PE, Kelley WN. Adenosine deaminiase: characteristics of the normal and mutant forms of the human enzyme. Ciba Foundation Symposium. 177-91. PMID 387356  0.28
1987 Hidaka Y, Tarlé SA, O'Toole TE, Kelley WN, Palella TD. Nucleotide sequence of the human APRT gene. Nucleic Acids Research. 15: 9086. PMID 3684585 DOI: 10.1093/Nar/15.21.9086  0.28
1978 Mitchell BS, Mejias E, Daddona PE, Kelley WN. Purinogenic immunodeficiency diseases: selective toxicity of deoxyribonucleosides for T cells. Proceedings of the National Academy of Sciences of the United States of America. 75: 5011-4. PMID 311004 DOI: 10.1073/Pnas.75.10.5011  0.278
1974 Postlethwaite AE, Ramsdell CM, Kelley WN. Uricosuric effect of an anticholinergic agent in hyperuricemic subjects. Advances in Experimental Medicine and Biology. 41: 769-76. PMID 4832607 DOI: 10.1001/Archinte.1974.00320200080010  0.277
1972 Holmes EW, Kelley WN, Wyngaarden JB. Editorial: The kidney and uric acid excretion in man Kidney International. 2: 115-118. PMID 4360739 DOI: 10.1038/Ki.1972.81  0.275
1975 Holmes Hr. EW, Kelley WN. An analysis of the bidirectional transport of uric acid by the human nephron Arthritis and Rheumatism. 18: 811-815. PMID 1201125 DOI: 10.1002/Art.1780180726  0.275
1977 Kelley WN, Daddona PE, van der Weyden MB. Characterization of human adenosine deaminase. Ciba Foundation Symposium. 277-93. PMID 24530  0.274
1975 Kelley WN. Pharmacologic approach to the maintenance of urate homeostasis Nephron. 14: 99-115. PMID 1091870 DOI: 10.1159/000180439  0.27
1966 KELLEY WN. Acetazolamide in Phenobarbital Intoxication Archives of Internal Medicine. 117: 64. DOI: 10.1001/Archinte.1966.03870070078011  0.268
1984 Dalke AP, Kazmers IS, Kelley WN. Hypoxanthine-guanine phosphoribosyltransferase-independent toxicity of azathioprine in human lymphoblasts. Biochemical Pharmacology. 33: 2692-5. PMID 6540565 DOI: 10.1016/0006-2952(84)90648-8  0.266
1974 Leyva A, Kelley WN. Measurement of DNA in cultured human cells Analytical Biochemistry. 62: 173-179. PMID 4473914 DOI: 10.1016/0003-2697(74)90378-9  0.264
1974 Postlethwaite AE, Gutman RA, Kelley WN. Salicylate-mediated increase in urate removal during hemodialysis: Evidence for urate binding to protein in vivo Metabolism. 23: 771-777. PMID 4854190 DOI: 10.1016/0026-0495(74)90009-2  0.255
1983 Kazmers IS, Daddona PE, Dalke AP, Kelley WN. Effect of immunosuppressive agents on human T and B lymphoblasts. Biochemical Pharmacology. 32: 805-10. PMID 6404281 DOI: 10.1016/0006-2952(83)90580-4  0.254
1978 Holden JA, Kelley WN. Human hypoxanthine-guanine phosphoribosyltransferase. Evidence for tetrameric structure. The Journal of Biological Chemistry. 253: 4459-63. PMID 659426  0.254
1969 Kelley WN, Goldfinger SE, Hardy HL. Hyperuricemia in chronic beryllium disease. Annals of Internal Medicine. 70: 977-83. PMID 5769630 DOI: 10.7326/0003-4819-70-5-977  0.254
1971 Fox IH, Kelley WN. Phosphoribosylpyrophosphate in man: biochemical and clinical significance. Annals of Internal Medicine. 74: 424-33. PMID 4324023 DOI: 10.7326/0003-4819-74-3-424  0.254
1991 Kelley WN. Gene therapy in humans: a new era begins. Annals of Internal Medicine. 114: 697-8. PMID 2003718 DOI: 10.7326/0003-4819-114-8-697  0.254
1979 Daddona PE, Kelley WN. Human adenosine deaminase. Stoichiometry of the adenosine deaminase-binding protein complex. Biochimica Et Biophysica Acta. 580: 302-11. PMID 518903 DOI: 10.1016/0005-2795(79)90143-0  0.254
1975 Kelley WN. Disorders of purine metabolism in man Biochemical Society Transactions. 3: 1202-1205. DOI: 10.1042/Bst0031202  0.253
1976 Van der Weyden MB, Kelley WN. Human adenosine deaminase. Distribution and properties. The Journal of Biological Chemistry. 251: 5448-56. PMID 9388  0.249
1984 Daddona PE, Shewach DS, Kelley WN, Argos P, Markham AF, Orkin SH. Human adenosine deaminase. cDNA and complete primary amino acid sequence. The Journal of Biological Chemistry. 259: 12101-6. PMID 6090454  0.247
1974 Kelley WN, Wyngaarden JB. Enzymology of gout Advances in Enzymology and Related Areas of Molecular Biology. 41: 1-33. PMID 4608588 DOI: 10.1002/9780470122860.Ch1  0.246
2012 Kelley WN. A personal perspective on the early, early history of in vivo (DNA-based) gene therapy. Human Gene Therapy. 23: 541-6. PMID 22490204 DOI: 10.1089/Hum.2012.028  0.246
1974 Skyler JS, Neelon FA, Arnold WJ, Kelley WN, Lebovitz HE. Growth retardation in the Lesch-Nyhan syndrome. European Journal of Endocrinology. 75: 3-10. PMID 4363845 DOI: 10.1530/Acta.0.0750003  0.244
1974 Postlethwaite AE, Bartel AG, Kelley WN. Hyperuricemia induced by ethambutol Advances in Experimental Medicine and Biology. 41: 763-767. PMID 4832606 DOI: 10.1007/978-1-4757-1433-3_52  0.243
1979 Holden JA, Meredith GS, Kelley WN. Human adenine phosphoribosyltransferase. Affinity purification, subunit structure, amino acid composition, and peptide mapping. The Journal of Biological Chemistry. 254: 6951-5. PMID 457664  0.241
1972 Crawhall JC, Henderson JF, Kelley WN. Diagnosis and treatment of the Lesch-Nyhan syndrome. Pediatric Research. 6: 504-13. PMID 4558815 DOI: 10.1203/00006450-197205000-00004  0.238
1988 Palella TD, Silverman LJ, Levine M, Kelley WN. 107 HERPES SIMPLEX VIRUS (HSV-1) MEDIATED HUMAN HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE (HPRT) GENE TRANSFER INTO NEURONAL CELLS Pediatric Research. 24: 129-129. DOI: 10.1203/00006450-198807000-00131  0.232
2008 Kelley WN. ASCI: reflections on the first 100 years and a proposal for the next. The Journal of Clinical Investigation. 118: 1217-9. PMID 18382724 DOI: 10.1172/Jci34652  0.232
1977 Daddona PE, Kelley WN. Human adenosine deaminase. Purification and subunit structure. The Journal of Biological Chemistry. 252: 110-5. PMID 13062  0.231
1987 Kelley WN. A new role for the ARA in guiding our destiny. Arthritis and Rheumatism. 30: 1201-4. PMID 3689458 DOI: 10.1002/Art.1780301101  0.228
1984 Daddona PE, Wiesmann WP, Lambros C, Kelley WN, Webster HK. Human malaria parasite adenosine deaminase. Characterization in host enzyme-deficient erythrocyte culture. The Journal of Biological Chemistry. 259: 1472-5. PMID 6363411  0.223
1995 Kelley WN. Human embryo research deserves public support. Nature Medicine. 1: 2. PMID 7584943 DOI: 10.1038/Nm0195-2A  0.223
2009 Kelley WN. Tapping the riches of science Journal of Clinical Investigation. 119: 2118-2118. DOI: 10.1172/Jci40271  0.222
1991 Mimori A, Hidaka Y, Wu VC, Tarlé SA, Kamatani N, Kelley WN, Pallela TD. A mutant allele common to the type I adenine phosphoribosyltransferase deficiency in Japanese subjects. American Journal of Human Genetics. 48: 103-7. PMID 1985452  0.218
1992 Kelley WN, Stross JK. Faculty tracks and academic success. Annals of Internal Medicine. 116: 654-9. PMID 1546867 DOI: 10.7326/0003-4819-116-8-654  0.217
2009 Kelley WN. Academic medicine and real health care reform. The Journal of Clinical Investigation. 119: 2852. PMID 20069709 DOI: 10.1172/Jci40986  0.213
1972 Postlethwaite AE, Bartel AG, Kelley WN. Hyperuricemia due to ethambutol. The New England Journal of Medicine. 286: 761-2. PMID 5025779 DOI: 10.1056/Nejm197204062861407  0.213
2014 Thier SO, Kelley WN, Pardes H, Knight AW, Wietecha M. Success factors in merging teaching hospitals. Academic Medicine : Journal of the Association of American Medical Colleges. 89: 219-23. PMID 24362373 DOI: 10.1097/Acm.0000000000000094  0.21
1974 Leyva A, Kelley WN. Differential effect of cycloheximide and puromycin on enzyme activity and protein degradation in cultured human cells Federation Proceedings. 33: No. 1210.  0.21
2003 Kelley WN. From the double helix to genomic medicine. Annals of Internal Medicine. 138: 603-4. PMID 12667033 DOI: 10.7326/0003-4819-138-7-200304010-00019  0.208
1984 Kelley WN. Clinical investigation and the clinical investigator: the past, present, and future. The Journal of Clinical Investigation. 74: 1117-22. PMID 6381538 DOI: 10.1172/Jci111481  0.207
1989 McMahon LF, Creighton FA, Bernard AM, Pittinger WB, Kelley WN. The integrated inpatient management model. A new approach to clinical practice. Annals of Internal Medicine. 111: 318-26. PMID 2502941 DOI: 10.7326/0003-4819-111-4-318  0.207
1971 Postlethwaite AE, Kelley WN. Uricosuric effect of radiocontrast agents. A study in man of four commonly used preparations. Annals of Internal Medicine. 74: 845-52. PMID 5580635 DOI: 10.7326/0003-4819-74-6-845  0.206
1995 Kelley WN. Two plans. The Pennsylvania strategy. Archives of Surgery (Chicago, Ill. : 1960). 130: 933-4. PMID 7661671 DOI: 10.1001/Archsurg.1995.01430090019007  0.205
1971 Kelley WN. Uricosuria and x-ray contrast agents. The New England Journal of Medicine. 284: 975-6. PMID 5573284 DOI: 10.1056/Nejm197104292841712  0.204
2019 Weinblatt ME, Kelley WN. In Memoriam: Shaun Ruddy, MD, 1935-2019. Arthritis & Rheumatology (Hoboken, N.J.). 71: 1215-1216. PMID 31353873 DOI: 10.1002/Art.40916  0.203
1975 Weinshilboum RM, Goldstein JL, Kelley WN. Prolonged hypouricemia associated with acute chlorprothixene ingestion Arthritis and Rheumatism. 18: 739-741. PMID 1201117 DOI: 10.1002/Art.1780180716  0.202
1976 Van der Weyden MB, Kelley WN. Adenosine deaminase and immune function. British Journal of Haematology. 34: 159-65. PMID 788771 DOI: 10.1111/J.1365-2141.1976.Tb00187.X  0.201
1996 Fogelman AM, Goode LD, Behrens BL, DeAngelis CD, Forsyth JD, Gewertz BL, Houpt JL, Hutton JJ, Kelley WN, Korn D, Marton LJ, Tartaglia AP, Wallace AG, Wallin WR, Walters FM. Preserving medical schools' academic mission in a competitive marketplace. Academic Medicine : Journal of the Association of American Medical Colleges. 71: 1168-99. PMID 9217507 DOI: 10.1097/00001888-199611000-00015  0.199
1994 Kelley WN. The impact of gene therapy on medicine and society. Annals of the New York Academy of Sciences. 716: 12-8; discussion 18-. PMID 8024190 DOI: 10.1111/J.1749-6632.1994.Tb21700.X  0.197
1996 Ralston HJ, Beattie DS, Berns KI, Goode LD, Kelley WN, Lennarz WJ, Marton LJ, Prange AJ, Shipp AC. Capturing the promise of science in medical schools. Academic Medicine : Journal of the Association of American Medical Colleges. 71: 1314-23. PMID 9114889 DOI: 10.1097/00001888-199612000-00013  0.195
2005 Kelley WN. 2005 Association Of American Physicians Kober medal. Acceptance of the 2005 Kober medal. The Journal of Clinical Investigation. 115: 2952-3. PMID 16200217 DOI: 10.1172/Jci26872  0.195
1995 Kelley WN, Randolph MA. Careers in clinical research: Obstacles and opportunities Journal of the American Medical Association. 273: 12. DOI: 10.1001/Jama.1995.03520250026008  0.195
1982 Davis WK, Kelley WN. Factors influencing decisions to enter careers in clinical investigation. Journal of Medical Education. 57: 275-81. PMID 7062322 DOI: 10.1097/00001888-198204000-00001  0.195
2007 Neill US, Thompson CB, Feldmann M, Kelley WN. A new JCI conflict-of-interest policy. The Journal of Clinical Investigation. 117: 506-8. PMID 17332875 DOI: 10.1172/Jci31587  0.192
1970 Kelley WN, Fox IH, Feldman JM, Wyngaarden JB. Glycosuria in alkaptonuria--a dilemma. Lancet (London, England). 2: 1363-4. PMID 4188122 DOI: 10.1016/S0140-6736(69)90903-9  0.191
1995 Kelley WN. Presentation of the 1995 Robert H. Williams Distinguished Chair of Medicine Award to William Nimmons Kelley, MD The American Journal of Medicine. 98: 425-428. PMID 7733118 DOI: 10.1016/S0002-9343(99)80339-8  0.189
1983 Orkin SH, Daddona PE, Shewach DS, Markham AF, Bruns GA, Goff SC, Kelley WN. Molecular cloning of human adenosine deaminase gene sequences. The Journal of Biological Chemistry. 258: 12753-6. PMID 6688808  0.185
1976 Kelley WN. Current therapy of gout and hyperuricemia. Hospital Practice. 11: 69-76. PMID 1027698 DOI: 10.1080/21548331.1976.11706934  0.185
1996 Genel M, Kelley WN, Chesney RW, Starfield B, Cohen HJ, Murray TH. 1995 Public Policy Plenary Symposium: "the crisis in clinical research". Pediatric Research. 39: 902-13. PMID 8726249 DOI: 10.1203/00006450-199605000-00027  0.183
1992 Kelley WN. Primary care and subspecialty medicine: fostering a unified internal medicine. Journal of General Internal Medicine. 7: 221-4. PMID 1487771 DOI: 10.1007/Bf02598019  0.179
1980 Daddona PE, Frohman MA, Kelley WN. Human adenosine deaminase and its binding protein in normal and adenosine deaminase-deficient fibroblast cell strains. The Journal of Biological Chemistry. 255: 5681-7. PMID 7380831  0.171
1986 Daddona PE, Orkin SH, Kelley WN. Expression defects of mutant human adenosine deaminase. Advances in Experimental Medicine and Biology. 195: 217-22. PMID 3755276  0.161
1973 Thomas CB, Arnold WJ, Kelley WN. Human adenine phosphoribosyltransferase. Purification, subunit structure, and substrate specificity Journal of Biological Chemistry. 248: 2529-2535. PMID 4349039  0.16
1973 Holmes EW, Wyngaarden JB, Kelley WN. Human glutamine phosphoribosylpyrophosphate amidotransferase. Two molecular forms interconvertible by purine ribonucleotides and phosphoribosylpyrophosphate Journal of Biological Chemistry. 248: 6035-6040. PMID 4726295  0.153
1984 Palella TD, Kelley WN. An approach to hyperuricemia and gout. Geriatrics. 39: 89-92, 95-6, 101-2. PMID 6489762  0.15
1976 Groebner W, Kelley WN. The effect of nucleotides on the molecular size of human orotate phosphoribosyltransferase and orotidine 5 phosphate decarboxylase Journal of Clinical Chemistry and Clinical Biochemistry. 14: 292.  0.148
1978 Arnold WJ, Kelley WN. [77] Adenine phosphoribosyltransferase Methods in Enzymology. 51: 568-574. DOI: 10.1016/S0076-6879(78)51079-3  0.142
1978 Daddona PE, Kelley WN. Human adenosine deaminase binding protein. Assay, purification, and properties. The Journal of Biological Chemistry. 253: 4617-23. PMID 659438  0.142
1973 Holmes EW, McDonald JA, McCord JM, Wyngaarden JB, Kelley WN. Human glutamine phosphoribosylpyrophosphate amidotransferase. Kinetic and regulatory properties Journal of Biological Chemistry. 248: 144-150. PMID 4348202  0.134
1973 Postlethwaite AE, Gutman RA, Kelley WN. Salicylate mediated increase in uric acid removal during hemodialysis: evidence for urate binding in vivo Israel Journal of Medical Sciences. 9: 1110.  0.131
1975 Rockson SG, Stone R, VanderWeyden M, Kelley WN. Abnormal adrenergic function in the Lesch Nyhan syndrome Clinical Research. 23: 14A.  0.127
1974 Kelley WN. Pathophysiology of purine metabolism in man Enzyme. 18: 161-175. PMID 4841658  0.124
1984 Wiesmann WP, Webster HK, Lambros C, Kelley WN, Daddona PE. Adenosine deaminase in malaria infected erythrocytes: unique parasite enzyme presents a new therapeutic target. Progress in Clinical and Biological Research. 165: 325-42. PMID 6334315  0.122
1971 Kelley WN, Fox IH, Beardmore TD, Meade JC. Allopurinol and oxipurinol: alteration of purine and pyrimidine metabolism in cell culture. Annals of the New York Academy of Sciences. 179: 588-95. PMID 4328264 DOI: 10.1111/j.1749-6632.1971.tb46935.x  0.121
1974 Groebner W, Kelley WN, Zoellner N. Effect of allopurinol on pyrimidine metabolism | ZUM EINFLUSS VON ALLOPURINOL AUF DEN PYRIMIDINSTOFFWECHSEL Verhandlungen Der Deutschen Gesellschaft Fur Innere Medizin. 1235-1237. PMID 4454384  0.116
1979 Kovarsky J, Holmes EW, Kelley WN. Absence of significant urate binding to human serum proteins. The Journal of Laboratory and Clinical Medicine. 93: 85-91. PMID 759530  0.106
1975 Kelley WN. Effects of drugs on uric acid in man Annual Review of Pharmacology. 15: 327-350. PMID 1096789  0.106
1975 Kelley WN. Hypouricemia Arthritis and Rheumatism. 18: 731-737. PMID 1239291  0.102
1973 Fox IH, Kelley WN. Pharmacological alterations of intracellular phosphoribosylpyrophosphate in human tissues Israel Journal of Medical Sciences. 9: 1094.  0.096
1994 Walters L, Areen J, Brewer MF, Capron A, Childress JF, Epstein CJ, Erickson RP, Gellert MF, Kelley WN, Leventhal BG, McIvor RS, Meyers AS, Miller DA, Murray RF, Neiman PE, et al. Minutes of the Human Gene Therapy Subcommittee meeting, November 21-22, 1991 Human Gene Therapy. 5: 229-262.  0.092
2021 Linderman MD, Paudyal C, Shakeel M, Kelley W, Bashir A, Gelb BD. NPSV: A simulation-driven approach to genotyping structural variants in whole-genome sequencing data. Gigascience. 10. PMID 34195837 DOI: 10.1093/gigascience/giab046  0.091
1976 Holmes EW, Kelley WN, Wyngaarden JB. Control of purine biosynthesis in normal and pathologic states Bulletin On the Rheumatic Diseases. 26: 848-853. PMID 1061631  0.087
1988 Kelley WN, Palella TD. The Jeremiah Metzger lecture. Current status of human gene therapy. Transactions of the American Clinical and Climatological Association. 99: 152-69. PMID 3332518  0.087
1989 Hidaka Y, Kelley WN, Levine M, Glorioso J, Silverman LJ, Palella TD. Expression of human hypoxanthine guanine phosphoribosyltransferase mRNA in brains of mice infected with a recombinant herpes simplex virus type 1. Transactions of the Association of American Physicians. 102: 91-100. PMID 2561645  0.079
2014 Zuo XN, Anderson JS, Bellec P, Birn RM, Biswal BB, Blautzik J, Breitner JC, Buckner RL, Calhoun VD, Castellanos FX, Chen A, Chen B, Chen J, Chen X, Colcombe SJ, ... ... Kelley W, et al. An open science resource for establishing reliability and reproducibility in functional connectomics. Scientific Data. 1: 140049. PMID 25977800 DOI: 10.1038/Sdata.2014.49  0.073
2016 Kosa P, Ghazali D, Tanigawa M, Barbour C, Cortese I, Kelley W, Snyder B, Ohayon J, Fenton K, Lehky T, Wu T, Greenwood M, Nair G, Bielekova B. Development of a Sensitive Outcome for Economical Drug Screening for Progressive Multiple Sclerosis Treatment. Frontiers in Neurology. 7: 131. PMID 27574516 DOI: 10.3389/Fneur.2016.00131  0.072
1973 Fox IH, Kelley WN. Studies of the mechanism of fructose induced hyperuricemia in man Israel Journal of Medical Sciences. 9: 1093.  0.061
2010 Perez AM, Pauszek SJ, Jimenez D, Kelley WN, Whedbee Z, Rodriguez LL. Spatial and phylogenetic analysis of vesicular stomatitis virus over-wintering in the United States. Preventive Veterinary Medicine. 93: 258-64. PMID 19962205 DOI: 10.1016/J.Prevetmed.2009.11.003  0.059
1985 Kelley WN. Personnel needs for clinical research: role of the clinical investigator. Clinical Research. 33: 100-4. PMID 3987193  0.055
1974 Postlethwaite AE, Ramsdell CM, Kelley WN. Uricosuric effect of anticholinergic agent in hyperuricemic subjects. Archives of Internal Medicine. 134: 270-5. PMID 4843194 DOI: 10.1001/archinte.1974.00320200080010  0.053
1988 Goldfinger SE, Benson JA, Eisenberg JM, Fallon HJ, Glassock RJ, Hazzard WR, Kelley WN, Langdon LO, Scherr L, Thier SO, Webster GD. The future internist Annals of Internal Medicine. 108: 139-141. PMID 3337491  0.053
1988 Kelley WN. Are we about to enter the golden era of clinical investigation? The Journal of Laboratory and Clinical Medicine. 111: 365-70. PMID 3280711  0.047
1982 Ginn RE, Case RA, Packard VS, Tatini SR, Bone E, Brizendine M, Curme A, Danilowier PR, Fuqua R, Grant HH, Heady J, Henrickson H, Kelley WN, Leslie JE, Schneider DE, et al. Quantitative estimates of beta-lactam residues in raw milk around a reference standard: collaborative study. Journal - Association of Official Analytical Chemists. 65: 1407-12. PMID 7174583  0.045
1982 Kelley WN. Qualitative ampule and multitest for beta-lactam residues in fluid milk products: collaborative study. Journal - Association of Official Analytical Chemists. 65: 1193-207. PMID 7130092  0.044
1974 Ramsdell CM, Kelley WN. The clinical significance of hypouricemia. Advances in Experimental Medicine and Biology. 41: 709-16. PMID 4832599  0.044
1978 Kelley WN. Improved automated optical somatic cell counting method for raw milk: collaborative study. Journal - Association of Official Analytical Chemists. 61: 1328-34. PMID 730636  0.041
2024 Kelley W, Zreik K, Gergen A, Williams J, Jacobson LE, Nahmias J, Tatar A, Murry J, Grigorian A, Ong A, Stein DM, Scalea TM, Lauerman MH. Early Pharmacologic Therapy in Patients With Blunt Cerebrovascular Injury and TBI: Is it Safe and Effective? An EAST Multicenter Study. The American Surgeon. 31348241230094. PMID 38253324 DOI: 10.1177/00031348241230094  0.041
2024 Kelley W, Ngo N, Dalca AV, Fischl B, Zöllei L, Hoffmann M. Boosting Skull-Stripping Performance for Pediatric Brain Images. Arxiv. PMID 38463507  0.038
2007 Rainwater-Lovett K, Pauszek SJ, Kelley WN, Rodriguez LL. Molecular epidemiology of vesicular stomatitis New Jersey virus from the 2004-2005 US outbreak indicates a common origin with Mexican strains. The Journal of General Virology. 88: 2042-51. PMID 17554039 DOI: 10.1099/vir.0.82644-0  0.037
2012 Ross S, Rosemurgy A, Albrink M, Choung E, Dapri G, Gallagher S, Hernandez J, Horgan S, Kelley W, Kia M, Marks J, Martinez J, Mintz Y, Oleynikov D, Pryor A, et al. Consensus statement of the consortium for LESS cholecystectomy. Surgical Endoscopy. 26: 2711-6. PMID 22936433 DOI: 10.1007/s00464-012-2478-y  0.029
1986 Chappell GS, Houglum JE, Kelley WN. Determination of oxytetracycline in premixes and veterinary products by liquid chromatography. Journal - Association of Official Analytical Chemists. 69: 28-30. PMID 3949693  0.025
1977 Wortmann RL, Kelley WN. Gout and hyperuricemia: A rational approach to management Clinical Therapeutics. 1: 159-184.  0.022
2001 Kelley WN, Tannen RL, Williams HC. Blueprint for discovery in academic medicine: plans, process and outcomes. Transactions of the American Clinical and Climatological Association. 112: 34-47; discussion 47. PMID 11413781  0.018
1974 Ramsdell CM, Postlethwaite AE, Kelley WN. Uricosuric effect of glyceryl guaiacolate. The Journal of Rheumatology. 1: 114-6. PMID 4617771  0.017
1995 Kelley WN, Randolph MA. From the Institute of Medicine. Jama. 273: 12. PMID 7996636  0.014
1962 Larson OK, Geddes NB, Kelley W. Miracle in the Evening Educational Theatre Journal. 14: 261. DOI: 10.2307/3204468  0.01
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