| Year |
Citation |
Score |
| 2023 |
Destro F, Joseph J, Srinivasan P, Kanter JM, Neufeld C, Wolfrum JM, Barone PW, Springs SL, Sinskey AJ, Cecchini S, Kotin RM, Braatz RD. Mechanistic modeling explains the production dynamics of recombinant adeno-associated virus with the baculovirus expression vector system. Molecular Therapy. Methods & Clinical Development. 30: 122-146. PMID 37746245 DOI: 10.1016/j.omtm.2023.05.019 |
0.333 |
|
| 2020 |
Hildebrandt E, Penzes JJ, Gifford RJ, Agbandje-Mckenna M, Kotin RM. Evolution of dependoparvoviruses across geological timescales-implications for design of AAV-based gene therapy vectors. Virus Evolution. 6: veaa043. PMID 32913662 DOI: 10.1093/Ve/Veaa043 |
0.444 |
|
| 2019 |
Kotin RM, Wright JF. Recombinant Adeno-Associated Virus Quality Control for Non-Clinical and Clinical Vectors: How an Unregulated Commercial Sector Can Compromise Development of New Gene Therapies. Human Gene Therapy. 30: 1447-1448. PMID 31860397 DOI: 10.1089/Hum.2019.29099.Rmk |
0.373 |
|
| 2017 |
Kotin RM, Snyder RO. Manufacturing clinical grade recombinant adeno-associated virus using invertebrate cell lines. Human Gene Therapy. PMID 28351174 DOI: 10.1089/Hum.2017.042 |
0.366 |
|
| 2016 |
Smith RH, Hallwirth CV, Westerman M, Hetherington NA, Tseng YS, Cecchini S, Virag T, Ziegler ML, Rogozin IB, Koonin EV, Agbandje-McKenna M, Kotin RM, Alexander IE. Germline viral "fossils" guide in silico reconstruction of a mid-Cenozoic era marsupial adeno-associated virus. Scientific Reports. 6: 28965. PMID 27377618 DOI: 10.1038/Srep28965 |
0.426 |
|
| 2016 |
Choudhury SR, Fitzpatrick Z, Harris AF, Maitland SA, Ferreira JS, Zhang Y, Ma S, Sharma RB, Gray-Edwards HL, Johnson JA, Johnson AK, Alonso LC, Punzo C, Wagner KR, Maguire CA, ... Kotin RM, et al. In vivo selection yields AAV-B1 capsid for CNS and muscle gene therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 27117222 DOI: 10.1038/Mt.2016.84 |
0.357 |
|
| 2016 |
Hallwirth CV, Smith RH, Westerman M, Hetherington NA, Tseng Y, Cecchini S, Virag T, Ziegler M, Rogozin IB, Koonin EV, Agbandje-McKenna M, Alexander IE, Kotin RM. 541. Use of Endogenous Viral Elements to Deduce the Sequence of an Ancient Adeno-Associated Virus That Circulated Amongst Australian Marsupials ~30 Million Years Ago Molecular Therapy. 24: S216. DOI: 10.1016/S1525-0016(16)33349-4 |
0.408 |
|
| 2014 |
Le Guiner C, Montus M, Servais L, Cherel Y, Francois V, Thibaud JL, Wary C, Matot B, Larcher T, Guigand L, Dutilleul M, Domenger C, Allais M, Beuvin M, Moraux A, ... ... Kotin RM, et al. Forelimb treatment in a large cohort of dystrophic dogs supports delivery of a recombinant AAV for exon skipping in Duchenne patients. Molecular Therapy : the Journal of the American Society of Gene Therapy. 22: 1923-35. PMID 25200009 DOI: 10.1038/Mt.2014.151 |
0.332 |
|
| 2013 |
Li L, Dimitriadis EK, Yang Y, Li J, Yuan Z, Qiao C, Beley C, Smith RH, Garcia L, Kotin RM. Production and characterization of novel recombinant adeno-associated virus replicative-form genomes: a eukaryotic source of DNA for gene transfer. Plos One. 8: e69879. PMID 23936358 DOI: 10.1371/Journal.Pone.0069879 |
0.516 |
|
| 2013 |
Airenne KJ, Hu YC, Kost TA, Smith RH, Kotin RM, Ono C, Matsuura Y, Wang S, Ylä-Herttuala S. Baculovirus: an insect-derived vector for diverse gene transfer applications. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 739-49. PMID 23439502 DOI: 10.1038/Mt.2012.286 |
0.414 |
|
| 2013 |
Barbash IM, Cecchini S, Faranesh AZ, Virag T, Li L, Yang Y, Hoyt RF, Kornegay JN, Bogan JR, Garcia L, Lederman RJ, Kotin RM. MRI roadmap-guided transendocardial delivery of exon-skipping recombinant adeno-associated virus restores dystrophin expression in a canine model of Duchenne muscular dystrophy. Gene Therapy. 20: 274-82. PMID 22551778 DOI: 10.1038/Gt.2012.38 |
0.431 |
|
| 2012 |
Denard J, Beley C, Kotin R, Lai-Kuen R, Blot S, Leh H, Asokan A, Samulski RJ, Moullier P, Voit T, Garcia L, Svinartchouk F. Human galectin 3 binding protein interacts with recombinant adeno-associated virus type 6. Journal of Virology. 86: 6620-31. PMID 22496229 DOI: 10.1128/Jvi.00297-12 |
0.385 |
|
| 2012 |
Bish LT, Sleeper MM, Forbes SC, Wang B, Reynolds C, Singletary GE, Trafny D, Morine KJ, Sanmiguel J, Cecchini S, Virag T, Vulin A, Beley C, Bogan J, Wilson JM, ... ... Kotin RM, et al. Long-term restoration of cardiac dystrophin expression in golden retriever muscular dystrophy following rAAV6-mediated exon skipping. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 580-9. PMID 22146342 DOI: 10.1038/Mt.2011.264 |
0.306 |
|
| 2012 |
Händel EM, Gellhaus K, Khan K, Bednarski C, Cornu TI, Müller-Lerch F, Kotin RM, Heilbronn R, Cathomen T. Versatile and efficient genome editing in human cells by combining zinc-finger nucleases with adeno-associated viral vectors. Human Gene Therapy. 23: 321-9. PMID 21980922 DOI: 10.1089/Hum.2011.140 |
0.531 |
|
| 2011 |
Kotin RM. Large-scale recombinant adeno-associated virus production. Human Molecular Genetics. 20: R2-6. PMID 21531790 DOI: 10.1093/Hmg/Ddr141 |
0.443 |
|
| 2011 |
Cecchini S, Virag T, Kotin RM. Reproducible high yields of recombinant adeno-associated virus produced using invertebrate cells in 0.02- to 200-liter cultures. Human Gene Therapy. 22: 1021-30. PMID 21381980 DOI: 10.1089/Hum.2010.250 |
0.371 |
|
| 2009 |
Virag T, Cecchini S, Kotin RM. Producing recombinant adeno-associated virus in foster cells: overcoming production limitations using a baculovirus-insect cell expression strategy. Human Gene Therapy. 20: 807-17. PMID 19604040 DOI: 10.1089/Hum.2009.092 |
0.387 |
|
| 2009 |
Smith RH, Levy JR, Kotin RM. A simplified baculovirus-AAV expression vector system coupled with one-step affinity purification yields high-titer rAAV stocks from insect cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 1888-96. PMID 19532142 DOI: 10.1038/Mt.2009.128 |
0.439 |
|
| 2009 |
Cecchini S, Negrete A, Virag T, Graham BS, Cohen JI, Kotin RM. Evidence of prior exposure to human bocavirus as determined by a retrospective serological study of 404 serum samples from adults in the United States. Clinical and Vaccine Immunology : Cvi. 16: 597-604. PMID 19244471 DOI: 10.1128/Cvi.00470-08 |
0.408 |
|
| 2008 |
Negrete A, Kotin RM. Large-scale production of recombinant adeno-associated viral vectors. Methods in Molecular Biology (Clifton, N.J.). 433: 79-96. PMID 18679618 DOI: 10.1007/978-1-59745-237-3_5 |
0.442 |
|
| 2008 |
Negrete A, Kotin RM. Strategies for manufacturing recombinant adeno-associated virus vectors for gene therapy applications exploiting baculovirus technology. Briefings in Functional Genomics & Proteomics. 7: 303-11. PMID 18632744 DOI: 10.1093/Bfgp/Eln034 |
0.431 |
|
| 2008 |
Smith RH, Yang L, Kotin RM. Chromatography-based purification of adeno-associated virus. Methods in Molecular Biology (Clifton, N.J.). 434: 37-54. PMID 18470638 DOI: 10.1007/978-1-60327-248-3_4 |
0.462 |
|
| 2008 |
Cecchini S, Negrete A, Kotin RM. Toward exascale production of recombinant adeno-associated virus for gene transfer applications. Gene Therapy. 15: 823-30. PMID 18401433 DOI: 10.1038/Gt.2008.61 |
0.384 |
|
| 2007 |
Szerlip NJ, Walbridge S, Yang L, Morrison PF, Degen JW, Jarrell ST, Kouri J, Kerr PB, Kotin R, Oldfield EH, Lonser RR. Real-time imaging of convection-enhanced delivery of viruses and virus-sized particles. Journal of Neurosurgery. 107: 560-7. PMID 17886556 DOI: 10.3171/Jns-07/09/0560 |
0.312 |
|
| 2007 |
Negrete A, Yang LC, Mendez AF, Levy JR, Kotin RM. Economized large-scale production of high yield of rAAV for gene therapy applications exploiting baculovirus expression system. The Journal of Gene Medicine. 9: 938-48. PMID 17764098 DOI: 10.1002/Jgm.1092 |
0.374 |
|
| 2007 |
Negrete A, Esteban G, Kotin RM. Process optimization of large-scale production of recombinant adeno-associated vectors using dielectric spectroscopy. Applied Microbiology and Biotechnology. 76: 761-72. PMID 17680241 DOI: 10.1007/S00253-007-1030-9 |
0.334 |
|
| 2007 |
Negrete A, Kotin RM. Production of recombinant adeno-associated vectors using two bioreactor configurations at different scales. Journal of Virological Methods. 145: 155-61. PMID 17606302 DOI: 10.1016/J.Jviromet.2007.05.020 |
0.325 |
|
| 2007 |
Schirmer JM, Miyagi N, Rao VP, Ricci D, Federspiel MJ, Kotin RM, Russell SJ, McGregor CG. Recombinant adeno-associated virus vector for gene transfer to the transplanted rat heart. Transplant International : Official Journal of the European Society For Organ Transplantation. 20: 550-7. PMID 17403107 DOI: 10.1111/J.1432-2277.2007.00479.X |
0.343 |
|
| 2007 |
Li L, Yang L, Scudiero DA, Miller SA, Yu ZX, Stukenberg PT, Shoemaker RH, Kotin RM. Development of recombinant adeno-associated virus vectors carrying small interfering RNA (shHec1)-mediated depletion of kinetochore Hec1 protein in tumor cells. Gene Therapy. 14: 814-27. PMID 17330085 DOI: 10.1038/sj.gt.3302933 |
0.308 |
|
| 2006 |
Thorsen F, Afione S, Huszthy PC, Tysnes BB, Svendsen A, Bjerkvig R, Kotin RM, Lønning PE, Hoover F. Adeno-associated virus (AAV) serotypes 2, 4 and 5 display similar transduction profiles and penetrate solid tumor tissue in models of human glioma. The Journal of Gene Medicine. 8: 1131-40. PMID 16810631 DOI: 10.1002/Jgm.939 |
0.405 |
|
| 2006 |
Urabe M, Nakakura T, Xin KQ, Obara Y, Mizukami H, Kume A, Kotin RM, Ozawa K. Scalable generation of high-titer recombinant adeno-associated virus type 5 in insect cells. Journal of Virology. 80: 1874-85. PMID 16439543 DOI: 10.1128/Jvi.80.4.1874-1885.2006 |
0.5 |
|
| 2006 |
Negrete A, Urabe MU, Kotin RM. 505. Advances in Large-Scale Production of Recombinant Adeno-Associated Vectors Molecular Therapy. 13: S195. DOI: 10.1016/J.Ymthe.2006.08.575 |
0.404 |
|
| 2005 |
Huszthy PC, Svendsen A, Wilson JM, Kotin RM, Lønning PE, Bjerkvig R, Hoover F. Widespread dispersion of adeno-associated virus serotype 1 and adeno-associated virus serotype 6 vectors in the rat central nervous system and in human glioblastoma multiforme xenografts. Human Gene Therapy. 16: 381-92. PMID 15812233 DOI: 10.1089/Hum.2005.16.381 |
0.448 |
|
| 2005 |
Harper SQ, Staber PD, He X, Eliason SL, Martins IH, Mao Q, Yang L, Kotin RM, Paulson HL, Davidson BL. RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model. Proceedings of the National Academy of Sciences of the United States of America. 102: 5820-5. PMID 15811941 DOI: 10.1073/Pnas.0501507102 |
0.325 |
|
| 2005 |
Li L, Yang L, Kotin RM. The DNA minor groove binding agents Hoechst 33258 and 33342 enhance recombinant adeno-associated virus (rAAV) transgene expression. The Journal of Gene Medicine. 7: 420-31. PMID 15538728 DOI: 10.1002/Jgm.681 |
0.442 |
|
| 2005 |
Li L, Yang L, Scudiero DA, Shoemaker RH, Kotin RM. 716. Transducing Efficiency Screening for rAAV2, rAAV1, and rAAV5 in 56 Human Tumor Cell Lines Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.256 |
0.398 |
|
| 2005 |
Urabe M, Nakakura T, Mizukami H, Kume A, Kotin RM, Ozawa K. 517. Type 1 Rep52 Is Superior to Authentic Rep52 for Producing Recombinant Adeno-Associated Virus Type 5 in Insect Cells Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.057 |
0.513 |
|
| 2005 |
Harper SQ, Staber PD, He X, Martins IH, Mao Q, Paulson HL, Kotin RM, Davidson BL. 52. AAV-Delivered RNAi Improves Cellular and Motor Phenotypes in a Mouse Model for Huntington's Disease Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.080 |
0.333 |
|
| 2004 |
Xia H, Mao Q, Eliason SL, Harper SQ, Martins IH, Orr HT, Paulson HL, Yang L, Kotin RM, Davidson BL. RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia. Nature Medicine. 10: 816-20. PMID 15235598 DOI: 10.1038/Nm1076 |
0.342 |
|
| 2004 |
Hickman AB, Ronning DR, Perez ZN, Kotin RM, Dyda F. The nuclease domain of adeno-associated virus rep coordinates replication initiation using two distinct DNA recognition interfaces. Molecular Cell. 13: 403-14. PMID 14967147 DOI: 10.1016/S1097-2765(04)00023-1 |
0.467 |
|
| 2004 |
Xia H, Mao Q, Eliason SL, Kiewiet N, Critchfield J, Martins IH, Harper SQ, He X, Kotin RM, Zoghbi HY, Orr HT, Paulson HL, Davidson BL. 717. RNAi Therapy for Dominant Neurodegenerative Diseases Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.623 |
0.329 |
|
| 2004 |
Urabe M, Nakakura T, Ozawa K, Kotin RM. 419. Production of Recombinant Adeno-Associated Virus Type 5 in Insect Cells Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.337 |
0.426 |
|
| 2004 |
Liu G, Kotin RM, Chiorini JA, Davidson BL. 230. Neural Progenitor Cell Transduction with AAV Serotypes 1 and 4 Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.178 |
0.359 |
|
| 2003 |
Lotery AJ, Yang GS, Mullins RF, Russell SR, Schmidt M, Stone EM, Lindbloom JD, Chiorini JA, Kotin RM, Davidson BL. Adeno-associated virus type 5: transduction efficiency and cell-type specificity in the primate retina. Human Gene Therapy. 14: 1663-71. PMID 14633408 DOI: 10.1089/104303403322542301 |
0.377 |
|
| 2003 |
Smith RH, Ding C, Kotin RM. Serum-free production and column purification of adeno-associated virus type 5. Journal of Virological Methods. 114: 115-24. PMID 14625046 DOI: 10.1016/J.Jviromet.2003.09.002 |
0.431 |
|
| 2002 |
Urabe M, Ding C, Kotin RM. Insect cells as a factory to produce adeno-associated virus type 2 vectors. Human Gene Therapy. 13: 1935-43. PMID 12427305 DOI: 10.1089/10430340260355347 |
0.454 |
|
| 2002 |
Hickman AB, Ronning DR, Kotin RM, Dyda F. Structural unity among viral origin binding proteins: crystal structure of the nuclease domain of adeno-associated virus Rep. Molecular Cell. 10: 327-37. PMID 12191478 DOI: 10.1016/S1097-2765(02)00592-0 |
0.486 |
|
| 2002 |
Smith RH, Afione SA, Kotin RM. Transposase-mediated construction of an integrated adeno-associated virus type 5 helper plasmid. Biotechniques. 33: 204-6, 208, 210-1. PMID 12139247 DOI: 10.2144/02331Dd04 |
0.487 |
|
| 2002 |
Mastakov MY, Baer K, Symes CW, Leichtlein CB, Kotin RM, During MJ. Immunological aspects of recombinant adeno-associated virus delivery to the mammalian brain. Journal of Virology. 76: 8446-54. PMID 12134047 DOI: 10.1128/Jvi.76.16.8446-8454.2002 |
0.434 |
|
| 2002 |
Yang GS, Schmidt M, Yan Z, Lindbloom JD, Harding TC, Donahue BA, Engelhardt JF, Kotin R, Davidson BL. Virus-mediated transduction of murine retina with adeno-associated virus: effects of viral capsid and genome size. Journal of Virology. 76: 7651-60. PMID 12097579 DOI: 10.1128/Jvi.76.15.7651-7660.2002 |
0.429 |
|
| 2002 |
Mastakov MY, Baer K, Kotin RM, During MJ. Recombinant adeno-associated virus serotypes 2- and 5-mediated gene transfer in the mammalian brain: quantitative analysis of heparin co-infusion. Molecular Therapy : the Journal of the American Society of Gene Therapy. 5: 371-80. PMID 11945063 DOI: 10.1006/Mthe.2002.0564 |
0.43 |
|
| 2002 |
Yamano S, Huang LY, Ding C, Chiorini JA, Goldsmith CM, Wellner RB, Golding B, Kotin RM, Scott DE, Baum BJ. Recombinant adeno-associated virus serotype 2 vectors mediate stable interleukin 10 secretion from salivary glands into the bloodstream. Human Gene Therapy. 13: 287-98. PMID 11812284 DOI: 10.1089/10430340252769806 |
0.408 |
|
| 2002 |
Ding C, Urabe M, Bergoin M, Kotin RM. Biochemical characterization of Junonia coenia densovirus nonstructural protein NS-1. Journal of Virology. 76: 338-45. PMID 11739698 DOI: 10.1128/Jvi.76.1.338-345.2002 |
0.427 |
|
| 2000 |
Yang YW, Kotin RM. Glucose-responsive gene delivery in pancreatic Islet cells via recombinant adeno-associated viral vectors. Pharmaceutical Research. 17: 1056-61. PMID 11087036 DOI: 10.1023/A:1026445426982 |
0.366 |
|
| 2000 |
Schmidt M, Afione S, Kotin RM. Adeno-associated virus type 2 Rep78 induces apoptosis through caspase activation independently of p53. Journal of Virology. 74: 9441-50. PMID 11000213 DOI: 10.1128/Jvi.74.20.9441-9450.2000 |
0.339 |
|
| 2000 |
Zabner J, Seiler M, Walters R, Kotin RM, Fulgeras W, Davidson BL, Chiorini JA. Adeno-associated virus type 5 (AAV5) but not AAV2 binds to the apical surfaces of airway epithelia and facilitates gene transfer. Journal of Virology. 74: 3852-8. PMID 10729159 DOI: 10.1128/Jvi.74.8.3852-3858.2000 |
0.417 |
|
| 2000 |
Smith RH, Kotin RM. An adeno-associated virus (AAV) initiator protein, Rep78, catalyzes the cleavage and ligation of single-stranded AAV ori DNA. Journal of Virology. 74: 3122-9. PMID 10708427 DOI: 10.1128/Jvi.74.7.3122-3129.2000 |
0.48 |
|
| 2000 |
Davidson BL, Stein CS, Heth JA, Martins I, Kotin RM, Derksen TA, Zabner J, Ghodsi A, Chiorini JA. Recombinant adeno-associated virus type 2, 4, and 5 vectors: transduction of variant cell types and regions in the mammalian central nervous system. Proceedings of the National Academy of Sciences of the United States of America. 97: 3428-32. PMID 10688913 DOI: 10.1073/Pnas.050581197 |
0.421 |
|
| 1999 |
Chiorini JA, Afione S, Kotin RM. Adeno-associated virus (AAV) type 5 Rep protein cleaves a unique terminal resolution site compared with other AAV serotypes. Journal of Virology. 73: 4293-8. PMID 10196327 DOI: 10.1128/Jvi.73.5.4293-4298.1999 |
0.528 |
|
| 1999 |
Chiorini JA, Kim F, Yang L, Kotin RM. Cloning and characterization of adeno-associated virus type 5. Journal of Virology. 73: 1309-19. PMID 9882336 DOI: 10.1128/Jvi.73.2.1309-1319.1999 |
0.524 |
|
| 1998 |
Braddon VR, Chiorini JA, Wang S, Kotin RM, Baum BJ. Adenoassociated virus-mediated transfer of a functional water channel into salivary epithelial cells in vitro and in vivo. Human Gene Therapy. 9: 2777-85. PMID 9874275 DOI: 10.1089/Hum.1998.9.18-2777 |
0.424 |
|
| 1998 |
Chiorini JA, Zimmermann B, Yang L, Smith RH, Ahearn A, Herberg F, Kotin RM. Inhibition of PrKX, a novel protein kinase, and the cyclic AMP-dependent protein kinase PKA by the regulatory proteins of adeno-associated virus type 2. Molecular and Cellular Biology. 18: 5921-9. PMID 9742109 DOI: 10.1128/Mcb.18.10.5921 |
0.377 |
|
| 1998 |
Maass G, Bogedain C, Scheer U, Michl D, Hörer M, Braun-Falco M, Volkenandt M, Schadendorf D, Wendtner CM, Winnacker EL, Kotin RM, Hallek M. Recombinant adeno-associated virus for the generation of autologous, gene-modified tumor vaccines: evidence for a high transduction efficiency into primary epithelial cancer cells. Human Gene Therapy. 9: 1049-59. PMID 9607416 DOI: 10.1089/Hum.1998.9.7-1049 |
0.375 |
|
| 1998 |
Smith RH, Kotin RM. The Rep52 gene product of adeno-associated virus is a DNA helicase with 3'-to-5' polarity. Journal of Virology. 72: 4874-81. PMID 9573254 DOI: 10.1128/Jvi.72.6.4874-4881.1998 |
0.458 |
|
| 1997 |
Chiorini JA, Yang L, Liu Y, Safer B, Kotin RM. Cloning of adeno-associated virus type 4 (AAV4) and generation of recombinant AAV4 particles. Journal of Virology. 71: 6823-33. PMID 9261407 DOI: 10.1128/Jvi.71.9.6823-6833.1997 |
0.489 |
|
| 1997 |
Smith RH, Spano AJ, Kotin RM. The Rep78 gene product of adeno-associated virus (AAV) self-associates to form a hexameric complex in the presence of AAV ori sequences. Journal of Virology. 71: 4461-71. PMID 9151837 DOI: 10.1128/Jvi.71.6.4461-4471.1997 |
0.475 |
|
| 1996 |
Chiorini JA, Wiener SM, Yang L, Smith RH, Safer B, Kilcoin NP, Liu Y, Urcelay E, Kotin RM. The roles of AAV Rep proteins in gene expression and targeted integration. Current Topics in Microbiology and Immunology. 218: 25-33. PMID 8794243 DOI: 10.1007/978-3-642-80207-2_2 |
0.513 |
|
| 1995 |
Chiorini JA, Wendtner CM, Urcelay E, Safer B, Hallek M, Kotin RM. High-efficiency transfer of the T cell co-stimulatory molecule B7-2 to lymphoid cells using high-titer recombinant adeno-associated virus vectors. Human Gene Therapy. 6: 1531-41. PMID 8664378 DOI: 10.1089/Hum.1995.6.12-1531 |
0.453 |
|
| 1995 |
Urcelay E, Ward P, Wiener SM, Safer B, Kotin RM. Asymmetric replication in vitro from a human sequence element is dependent on adeno-associated virus Rep protein. Journal of Virology. 69: 2038-46. PMID 7884849 DOI: 10.1128/Jvi.69.4.2038-2046.1995 |
0.519 |
|
| 1995 |
Chiorini JA, Yang L, Safer B, Kotin RM. Determination of adeno-associated virus Rep68 and Rep78 binding sites by random sequence oligonucleotide selection. Journal of Virology. 69: 7334-8. PMID 7474165 DOI: 10.1128/Jvi.69.11.7334-7338.1995 |
0.439 |
|
| 1994 |
Chiorini JA, Weitzman MD, Owens RA, Urcelay E, Safer B, Kotin RM. Biologically active Rep proteins of adeno-associated virus type 2 produced as fusion proteins in Escherichia coli. Journal of Virology. 68: 797-804. PMID 8289383 DOI: 10.1128/Jvi.68.2.797-804.1994 |
0.488 |
|
| 1994 |
Ward P, Urcelay E, Kotin R, Safer B, Berns KI. Adeno-associated virus DNA replication in vitro: activation by a maltose binding protein/Rep 68 fusion protein. Journal of Virology. 68: 6029-37. PMID 8057478 DOI: 10.1128/Jvi.68.9.6029-6037.1994 |
0.673 |
|
| 1994 |
Weitzman MD, Kyöstiö SR, Kotin RM, Owens RA. Adeno-associated virus (AAV) Rep proteins mediate complex formation between AAV DNA and its integration site in human DNA. Proceedings of the National Academy of Sciences of the United States of America. 91: 5808-12. PMID 8016070 DOI: 10.1073/Pnas.91.13.5808 |
0.51 |
|
| 1994 |
Kotin RM. Prospects for the use of adeno-associated virus as a vector for human gene therapy. Human Gene Therapy. 5: 793-801. PMID 7981305 DOI: 10.1089/Hum.1994.5.7-793 |
0.428 |
|
| 1994 |
Batchu RB, Kotin RM, Hermonat PL. The regulatory rep protein of adeno-associated virus binds to sequences within the c-H-ras promoter. Cancer Letters. 86: 23-31. PMID 7954351 DOI: 10.1016/0304-3835(94)90176-7 |
0.401 |
|
| 1994 |
Chiorini JA, Wiener SM, Owens RA, Kyöstió SR, Kotin RM, Safer B. Sequence requirements for stable binding and function of Rep68 on the adeno-associated virus type 2 inverted terminal repeats. Journal of Virology. 68: 7448-57. PMID 7933128 DOI: 10.1128/Jvi.68.11.7448-7457.1994 |
0.39 |
|
| 1992 |
Kotin RM, Linden RM, Berns KI. Characterization of a preferred site on human chromosome 19q for integration of adeno-associated virus DNA by non-homologous recombination. The Embo Journal. 11: 5071-8. PMID 1334463 DOI: 10.1002/J.1460-2075.1992.Tb05614.X |
0.696 |
|
| 1991 |
Kotin RM, Menninger JC, Ward DC, Berns KI. Mapping and direct visualization of a region-specific viral DNA integration site on chromosome 19q13-qter. Genomics. 10: 831-4. PMID 1653762 DOI: 10.1016/0888-7543(91)90470-Y |
0.655 |
|
| 1990 |
Kotin RM, Siniscalco M, Samulski RJ, Zhu XD, Hunter L, Laughlin CA, McLaughlin S, Muzyczka N, Rocchi M, Berns KI. Site-specific integration by adeno-associated virus. Proceedings of the National Academy of Sciences of the United States of America. 87: 2211-5. PMID 2156265 DOI: 10.1073/Pnas.87.6.2211 |
0.638 |
|
| 1989 |
Kotin RM, Berns KI. Organization of adeno-associated virus DNA in latently infected Detroit 6 cells. Virology. 170: 460-7. PMID 2543124 DOI: 10.1016/0042-6822(89)90437-6 |
0.683 |
|
| 1988 |
Berns KI, Kotin RM, Labow MA. Regulation of adeno-associated virus DNA replication. Biochimica Et Biophysica Acta. 951: 425-9. PMID 2850017 DOI: 10.1016/0167-4781(88)90116-9 |
0.649 |
|
| 1984 |
Kotin RM, Dubin DT. Sequences around the 3'-end of a ribosomal RNA gene of hamster mitochondria. Further support for the 'transcriptional attenuation' model. Biochimica Et Biophysica Acta. 782: 106-8. PMID 6722155 DOI: 10.1016/0167-4781(84)90112-X |
0.349 |
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