Hans (Johannes Carolus) Clevers - Publications

Affiliations: 
1991- Utrecht University, Utrecht, Netherlands 
Area:
Molecular genetics, Molecular immunology
Website:
http://knaw.nl/nl/leden/leden/3984

363 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Rosenbluth JM, Schackmann RCJ, Gray GK, Selfors LM, Li CM, Boedicker M, Kuiken HJ, Richardson A, Brock J, Garber J, Dillon D, Sachs N, Clevers H, Brugge JS. Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages. Nature Communications. 11: 1711. PMID 32249764 DOI: 10.1038/s41467-020-15548-7  1
2020 Ringel T, Frey N, Ringnalda F, Janjuha S, Cherkaoui S, Butz S, Srivatsa S, Pirkl M, Russo G, Villiger L, Rogler G, Clevers H, Beerenwinkel N, Zamboni N, Baubec T, et al. Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-β Resistance. Cell Stem Cell. 26: 431-440.e8. PMID 32142663 DOI: 10.1016/j.stem.2020.02.007  1
2020 Battich N, Beumer J, de Barbanson B, Krenning L, Baron CS, Tanenbaum ME, Clevers H, van Oudenaarden A. Sequencing metabolically labeled transcripts in single cells reveals mRNA turnover strategies. Science (New York, N.Y.). 367: 1151-1156. PMID 32139547 DOI: 10.1126/science.aax3072  1
2020 Artegiani B, Hendriks D, Beumer J, Kok R, Zheng X, Joore I, Chuva de Sousa Lopes S, van Zon J, Tans S, Clevers H. Fast and efficient generation of knock-in human organoids using homology-independent CRISPR-Cas9 precision genome editing. Nature Cell Biology. PMID 32123335 DOI: 10.1038/s41556-020-0472-5  1
2020 Pleguezuelos-Manzano C, Puschhof J, Huber AR, van Hoeck A, Wood HM, Nomburg J, Gurjao C, Manders F, Dalmasso G, Stege PB, Paganelli FL, Geurts MH, Beumer J, Mizutani T, van der Linden R, ... ... Clevers H, et al. Mutational signature in colorectal cancer caused by genotoxic pks E. coli. Nature. PMID 32106218 DOI: 10.1038/s41586-020-2080-8  1
2020 Wiechmann S, Maisonneuve P, Grebbin BM, Hoffmeister M, Kaulich M, Clevers H, Rajalingam K, Kurinov I, Farin HF, Sicheri F, Ernst A. Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids. The Journal of Biological Chemistry. PMID 32086379 DOI: 10.1074/jbc.RA119.011025  1
2020 Geurts MH, de Poel E, Amatngalim GD, Oka R, Meijers FM, Kruisselbrink E, van Mourik P, Berkers G, de Winter-de Groot KM, Michel S, Muilwijk D, Aalbers BL, Mullenders J, Boj SF, Suen SWF, ... ... Clevers H, et al. CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank. Cell Stem Cell. PMID 32084388 DOI: 10.1016/j.stem.2020.01.019  1
2019 van Es JH, Wiebrands K, López-Iglesias C, van de Wetering M, Zeinstra L, van den Born M, Korving J, Sasaki N, Peters PJ, van Oudenaarden A, Clevers H. Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion. Proceedings of the National Academy of Sciences of the United States of America. PMID 31843916 DOI: 10.1073/pnas.1801888117  1
2019 Giobbe GG, Crowley C, Luni C, Campinoti S, Khedr M, Kretzschmar K, De Santis MM, Zambaiti E, Michielin F, Meran L, Hu Q, van Son G, Urbani L, Manfredi A, Giomo M, ... ... Clevers H, et al. Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture. Nature Communications. 10: 5658. PMID 31827102 DOI: 10.1038/s41467-019-13605-4  1
2019 Driehuis E, van Hoeck A, Moore K, Kolders S, Francies HE, Gulersonmez MC, Stigter ECA, Burgering B, Geurts V, Gracanin A, Bounova G, Morsink FH, Vries R, Boj S, van Es J, ... ... Clevers H, et al. Pancreatic cancer organoids recapitulate disease and allow personalized drug screening. Proceedings of the National Academy of Sciences of the United States of America. PMID 31818951 DOI: 10.1073/pnas.1911273116  1
2019 de Winter-de Groot KM, Berkers G, Marck-van der Wilt REP, van der Meer R, Vonk A, Dekkers JF, Geerdink M, Michel S, Kruisselbrink E, Vries R, Clevers H, Vleggaar FP, Elias SG, Heijerman HGM, van der Ent CK, et al. Forskolin-induced swelling of intestinal organoids correlates with disease severity in adults with cystic fibrosis and homozygous F508del mutations. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. PMID 31735562 DOI: 10.1016/j.jcf.2019.10.022  1
2019 Schneeberger K, Sánchez-Romero N, Ye S, van Steenbeek FG, Oosterhoff LA, Pla Palacin I, Chen C, van Wolferen ME, van Tienderen G, Lieshout R, Colemonts-Vroninks H, Schene I, Hoekstra R, Verstegen MMA, van der Laan LJW, ... ... Clevers H, et al. Large-scale Production of LGR5-positive Bipotential Human Liver Stem Cells. Hepatology (Baltimore, Md.). PMID 31715015 DOI: 10.1002/hep.31037  1
2019 Ooft SN, Weeber F, Dijkstra KK, McLean CM, Kaing S, van Werkhoven E, Schipper L, Hoes L, Vis DJ, van de Haar J, Prevoo W, Snaebjornsson P, van der Velden D, Klein M, Chalabi M, ... ... Clevers H, et al. Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients. Science Translational Medicine. 11. PMID 31597751 DOI: 10.1126/scitranslmed.aay2574  1
2019 Ganesh K, Wu C, O'Rourke KP, Szeglin BC, Zheng Y, Sauvé CG, Adileh M, Wasserman I, Marco MR, Kim AS, Shady M, Sanchez-Vega F, Karthaus WR, Won HH, Choi SH, ... ... Clevers H, et al. A rectal cancer organoid platform to study individual responses to chemoradiation. Nature Medicine. PMID 31591597 DOI: 10.1038/s41591-019-0584-2  1
2019 Han S, Fink J, Jörg DJ, Lee E, Yum MK, Chatzeli L, Merker SR, Josserand M, Trendafilova T, Andersson-Rolf A, Dabrowska C, Kim H, Naumann R, Lee JH, Sasaki N, ... ... Clevers H, et al. Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells. Cell Stem Cell. PMID 31422913 DOI: 10.1016/j.stem.2019.07.008  1
2019 Klotz BJ, Oosterhoff LA, Utomo L, Lim KS, Vallmajo-Martin Q, Clevers H, Woodfield TBF, Rosenberg AJWP, Malda J, Ehrbar M, Spee B, Gawlitta D. A Versatile Biosynthetic Hydrogel Platform for Engineering of Tissue Analogues. Advanced Healthcare Materials. e1900979. PMID 31402634 DOI: 10.1002/adhm.201900979  1
2019 Boonekamp KE, Kretzschmar K, Wiener DJ, Asra P, Derakhshan S, Puschhof J, López-Iglesias C, Peters PJ, Basak O, Clevers H. Long-term expansion and differentiation of adult murine epidermal stem cells in 3D organoid cultures. Proceedings of the National Academy of Sciences of the United States of America. PMID 31253707 DOI: 10.1073/pnas.1715272116  1
2019 Clevers H, Conder RK, Li VSW, Lutolf MP, Vallier L, Chan S, Grikscheit TC, Jensen KB, De Coppi P. Tissue-Engineering the Intestine: The Trials before the Trials. Cell Stem Cell. 24: 855-859. PMID 31173715 DOI: 10.1016/j.stem.2019.04.018  1
2019 Artegiani B, van Voorthuijsen L, Lindeboom RGH, Seinstra D, Heo I, Tapia P, López-Iglesias C, Postrach D, Dayton T, Oka R, Hu H, van Boxtel R, van Es JH, Offerhaus J, Peters PJ, ... ... Clevers H, et al. Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids. Cell Stem Cell. PMID 31130514 DOI: 10.1016/j.stem.2019.04.017  1
2019 Dekkers JF, Alieva M, Wellens LM, Ariese HCR, Jamieson PR, Vonk AM, Amatngalim GD, Hu H, Oost KC, Snippert HJG, Beekman JM, Wehrens EJ, Visvader JE, Clevers H, Rios AC. High-resolution 3D imaging of fixed and cleared organoids. Nature Protocols. PMID 31053799 DOI: 10.1038/s41596-019-0160-8  1
2019 Driehuis E, Kolders S, Spelier S, Lohmussaar K, Willems SM, Devriese LA, de Bree R, de Ruiter EJ, Korving J, Begthel H, Van Es JH, Geurts V, He GW, van Jaarsveld RH, Oka R, ... ... Clevers H, et al. Oral mucosal organoids as a potential platform for personalized cancer therapy. Cancer Discovery. PMID 31053628 DOI: 10.1158/2159-8290.CD-18-1522  1
2019 Bolhaqueiro ACF, Ponsioen B, Bakker B, Klaasen SJ, Kucukkose E, van Jaarsveld RH, Vivié J, Verlaan-Klink I, Hami N, Spierings DCJ, Sasaki N, Dutta D, Boj SF, Vries RGJ, Lansdorp PM, ... ... Clevers H, et al. Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids. Nature Genetics. PMID 31036964 DOI: 10.1038/s41588-019-0399-6  1
2019 Kopper O, de Witte CJ, Lõhmussaar K, Valle-Inclan JE, Hami N, Kester L, Balgobind AV, Korving J, Proost N, Begthel H, van Wijk LM, Revilla SA, Theeuwsen R, van de Ven M, van Roosmalen MJ, ... ... Clevers H, et al. An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity. Nature Medicine. PMID 31011202 DOI: 10.1038/s41591-019-0422-6  1
2019 Cabeza-Cabrerizo M, van Blijswijk J, Wienert S, Heim D, Jenkins RP, Chakravarty P, Rogers N, Frederico B, Acton S, Beerling E, van Rheenen J, Clevers H, Schraml BU, Bajénoff M, Gerner M, et al. Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors. Science Immunology. 4. PMID 30824528 DOI: 10.1126/sciimmunol.aaw1941  1
2019 Mullenders J, de Jongh E, Brousali A, Roosen M, Blom JPA, Begthel H, Korving J, Jonges T, Kranenburg O, Meijer R, Clevers HC. Mouse and human urothelial cancer organoids: A tool for bladder cancer research. Proceedings of the National Academy of Sciences of the United States of America. PMID 30787188 DOI: 10.1073/pnas.1803595116  1
2019 Berkers G, van Mourik P, Vonk AM, Kruisselbrink E, Dekkers JF, de Winter-de Groot KM, Arets HGM, Marck-van der Wilt REP, Dijkema JS, Vanderschuren MM, Houwen RHJ, Heijerman HGM, van de Graaf EA, Elias SG, Majoor CJ, ... ... Clevers HC, et al. Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis. Cell Reports. 26: 1701-1708.e3. PMID 30759382 DOI: 10.1016/j.celrep.2019.01.068  1
2019 Gehart H, van Es JH, Hamer K, Beumer J, Kretzschmar K, Dekkers JF, Rios A, Clevers H. Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping. Cell. PMID 30712869 DOI: 10.1016/j.cell.2018.12.029  1
2019 Basham KJ, Rodriguez S, Turcu AF, Lerario AM, Logan CY, Rysztak MR, Gomez-Sanchez CE, Breault DT, Koo BK, Clevers H, Nusse R, Val P, Hammer GD. A ZNRF3-dependent Wnt/β-catenin signaling gradient is required for adrenal homeostasis. Genes & Development. PMID 30692207 DOI: 10.1101/gad.317412.118  1
2019 Sachs N, Papaspyropoulos A, Zomer-van Ommen DD, Heo I, Böttinger L, Klay D, Weeber F, Huelsz-Prince G, Iakobachvili N, Amatngalim GD, de Ligt J, van Hoeck A, Proost N, Viveen MC, Lyubimova A, ... ... Clevers H, et al. Long-term expanding human airway organoids for disease modeling. The Embo Journal. PMID 30643021 DOI: 10.15252/embj.2018100300  1
2018 Kretzschmar K, Post Y, Bannier-Hélaouët M, Mattiotti A, Drost J, Basak O, Li VSW, van den Born M, Gunst QD, Versteeg D, Kooijman L, van der Elst S, van Es JH, van Rooij E, van den Hoff MJB, ... Clevers H, et al. Profiling proliferative cells and their progeny in damaged murine hearts. Proceedings of the National Academy of Sciences of the United States of America. 115: E12245-E12254. PMID 30530645 DOI: 10.1073/pnas.1805829115  1
2018 Yan HHN, Siu HC, Law S, Ho SL, Yue SSK, Tsui WY, Chan D, Chan AS, Ma S, Lam KO, Bartfeld S, Man AHY, Lee BCH, Chan ASY, Wong JWH, ... ... Clevers H, et al. A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening. Cell Stem Cell. PMID 30344100 DOI: 10.1016/j.stem.2018.09.016  1
2018 Chan LH, Zhou L, Ng KY, Wong TL, Lee TK, Sharma R, Loong JH, Ching YP, Yuan YF, Xie D, Lo CM, Man K, Artegiani B, Clevers H, Yan HH, et al. PRMT6 Regulates RAS/RAF Binding and MEK/ERK-Mediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation. Cell Reports. 25: 690-701.e8. PMID 30332648 DOI: 10.1016/j.celrep.2018.09.053  1
2018 de Winter-de Groot KM, Janssens HM, van Uum RT, Dekkers JF, Berkers G, Vonk A, Kruisselbrink E, Oppelaar H, Vries R, Clevers H, Houwen RHJ, Escher JC, Elias SG, de Jonge HR, de Rijke YB, et al. Stratifying infants with cystic fibrosis for disease severity using intestinal organoid swelling as biomarker of CFTR function. The European Respiratory Journal. PMID 30166324 DOI: 10.1183/13993003.02529-2017  1
2018 Beumer J, Artegiani B, Post Y, Reimann F, Gribble F, Nguyen TN, Zeng H, Van den Born M, Van Es JH, Clevers H. Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient. Nature Cell Biology. PMID 30038251 DOI: 10.1038/s41556-018-0143-y  1
2018 Hui KPY, Ching RHH, Chan SKH, Nicholls JM, Sachs N, Clevers H, Peiris JSM, Chan MCW. Tropism, replication competence, and innate immune responses of influenza virus: an analysis of human airway organoids and ex-vivo bronchus cultures. The Lancet. Respiratory Medicine. PMID 30001996 DOI: 10.1016/S2213-2600(18)30236-4  1
2018 Wiener DJ, Basak O, Asra P, Boonekamp KE, Kretzschmar K, Papaspyropoulos A, Clevers H. Establishment and characterization of a canine keratinocyte organoid culture system. Veterinary Dermatology. PMID 29963730 DOI: 10.1111/vde.12541  1
2018 Heo I, Dutta D, Schaefer DA, Iakobachvili N, Artegiani B, Sachs N, Boonekamp KE, Bowden G, Hendrickx APA, Willems RJL, Peters PJ, Riggs MW, O'Connor R, Clevers H. Modelling Cryptosporidium infection in human small intestinal and lung organoids. Nature Microbiology. 3: 814-823. PMID 29946163 DOI: 10.1038/s41564-018-0177-8  1
2018 Zhou J, Li C, Sachs N, Chiu MC, Wong BH, Chu H, Poon VK, Wang D, Zhao X, Wen L, Song W, Yuan S, Wong KK, Chan JF, To KK, ... ... Clevers H, et al. Differentiated human airway organoids to assess infectivity of emerging influenza virus. Proceedings of the National Academy of Sciences of the United States of America. PMID 29891677 DOI: 10.1073/pnas.1806308115  1
2018 Tiriac H, Belleau P, Engle DD, Plenker D, Deschênes A, Somerville T, Froeling FEM, Burkhart RA, Denroche RE, Jang GH, Miyabayashi K, Young CM, Patel H, Ma M, LaComb JF, ... ... Clevers H, et al. Organoid profiling identifies common responders to chemotherapy in pancreatic cancer. Cancer Discovery. PMID 29853643 DOI: 10.1158/2159-8290.CD-18-0349  1
2018 Chen C, Jochems P, Salz L, Schneeberger K, Penning LC, van de Graaf SFJ, Beuers U, Clevers H, Geijsen N, Masereeuw R, Spee B. Bioengineered bile ducts recapitulate key cholangiocyte functions. Biofabrication. PMID 29848792 DOI: 10.1088/1758-5090/aac8fd  1
2018 Chakrabarti R, Celià-Terrassa T, Kumar S, Hang X, Wei Y, Choudhury A, Hwang J, Peng J, Nixon B, Grady JJ, DeCoste C, Gao J, van Es JH, Li MO, Aifantis I, ... Clevers H, et al. Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche. Science (New York, N.Y.). PMID 29773667 DOI: 10.1126/science.aan4153  1
2018 Grinenko T, Eugster A, Thielecke L, Ramasz B, Krüger A, Dietz S, Glauche I, Gerbaulet A, von Bonin M, Basak O, Clevers H, Chavakis T, Wielockx B. Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice. Nature Communications. 9: 1898. PMID 29765026 DOI: 10.1038/s41467-018-04188-7  1
2018 Harris A, Siggers P, Corrochano S, Warr N, Sagar D, Grimes DT, Suzuki M, Burdine RD, Cong F, Koo BK, Clevers H, Stévant I, Nef S, Wells S, Brauner R, et al. ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling. Proceedings of the National Academy of Sciences of the United States of America. PMID 29735715 DOI: 10.1073/pnas.1801223115  1
2018 Roerink SF, Sasaki N, Lee-Six H, Young MD, Alexandrov LB, Behjati S, Mitchell TJ, Grossmann S, Lightfoot H, Egan DA, Pronk A, Smakman N, van Gorp J, Anderson E, Gamble SJ, ... ... Clevers H, et al. Intra-tumour diversification in colorectal cancer at the single-cell level. Nature. PMID 29643510 DOI: 10.1038/s41586-018-0024-3  1
2018 Loomans CJM, Williams Giuliani N, Balak J, Ringnalda F, van Gurp L, Huch M, Boj SF, Sato T, Kester L, de Sousa Lopes SMC, Roost MS, Bonner-Weir S, Engelse MA, Rabelink TJ, Heimberg H, ... ... Clevers H, et al. Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential. Stem Cell Reports. 10: 712-724. PMID 29539434 DOI: 10.1016/j.stemcr.2018.02.005  1
2018 Basak O, Krieger TG, Muraro MJ, Wiebrands K, Stange DE, Frias-Aldeguer J, Rivron NC, van de Wetering M, van Es JH, van Oudenaarden A, Simons BD, Clevers H. Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy. Proceedings of the National Academy of Sciences of the United States of America. PMID 29311336 DOI: 10.1073/pnas.1715911114  1
2018 Sachs N, de Ligt J, Kopper O, Gogola E, Bounova G, Weeber F, Balgobind AV, Wind K, Gracanin A, Begthel H, Korving J, van Boxtel R, Duarte AA, Lelieveld D, van Hoeck A, ... ... Clevers H, et al. A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity. Cell. 172: 373-386.e10. PMID 29224780 DOI: 10.1016/j.cell.2017.11.010  1
2018 Jager M, Blokzijl F, Sasselli V, Boymans S, Janssen R, Besselink N, Clevers H, van Boxtel R, Cuppen E. Measuring mutation accumulation in single human adult stem cells by whole-genome sequencing of organoid cultures. Nature Protocols. 13: 59-78. PMID 29215633 DOI: 10.1038/nprot.2017.111  1
2017 Duarte AA, Gogola E, Sachs N, Barazas M, Annunziato S, R de Ruiter J, Velds A, Blatter S, Houthuijzen JM, van de Ven M, Clevers H, Borst P, Jonkers J, Rottenberg S. BRCA-deficient mouse mammary tumor organoids to study cancer-drug resistance. Nature Methods. PMID 29256493 DOI: 10.1038/nmeth.4535  1
2017 Artegiani B, Lyubimova A, Muraro M, van Es JH, van Oudenaarden A, Clevers H. A Single-Cell RNA Sequencing Study Reveals Cellular and Molecular Dynamics of the Hippocampal Neurogenic Niche. Cell Reports. 21: 3271-3284. PMID 29241552 DOI: 10.1016/j.celrep.2017.11.050  1
2017 Regev A, Teichmann SA, Lander ES, Amit I, Benoist C, Birney E, Bodenmiller B, Campbell PJ, Carninci P, Clatworthy M, Clevers H, Deplancke B, Dunham I, Eberwine J, Eils R, et al. Science Forum: The Human Cell Atlas. Elife. 6. PMID 29206104 DOI: 10.7554/eLife.27041  1
2017 Andersson ER, Chivukula IV, Hankeova S, Sjöqvist M, Tsoi YL, Ramsköld D, Masek J, Elmansuri A, Hoogendoorn A, Vazquez E, Storvall H, Netušilová J, Huch M, Fischler B, Ellis E, ... ... Clevers H, et al. Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations. Gastroenterology. PMID 29162437 DOI: 10.1053/j.gastro.2017.11.002  1
2017 Steinhart Z, Pavlovic Z, Chandrashekhar M, Hart T, Wang X, Zhang X, Robitaille M, Brown KR, Jaksani S, Overmeer R, Boj SF, Adams J, Pan J, Clevers H, Sidhu S, et al. Corrigendum: Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors. Nature Medicine. 23: 1384. PMID 29117169 DOI: 10.1038/nm1117-1384d  1
2017 Drost J, van Boxtel R, Blokzijl F, Mizutani T, Sasaki N, Sasselli V, de Ligt J, Behjati S, Grolleman JE, van Wezel T, Nik-Zainal S, Kuiper RP, Cuppen E, Clevers H. Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer. Science (New York, N.Y.). 358: 234-238. PMID 28912133 DOI: 10.1126/science.aao3130  1
2017 Noguchi S, Arakawa T, Fukuda S, Furuno M, Hasegawa A, Hori F, Ishikawa-Kato S, Kaida K, Kaiho A, Kanamori-Katayama M, Kawashima T, Kojima M, Kubosaki A, Manabe RI, Murata M, ... ... Clevers HC, et al. FANTOM5 CAGE profiles of human and mouse samples. Scientific Data. 4: 170112. PMID 28850106 DOI: 10.1038/sdata.2017.112  1
2017 Dutta D, Clevers H. Organoid culture systems to study host-pathogen interactions. Current Opinion in Immunology. 48: 15-22. PMID 28756233 DOI: 10.1016/j.coi.2017.07.012  1
2017 Joosten SPJ, Zeilstra J, van Andel H, Mijnals RC, Zaunbrecher J, Duivenvoorden AAM, van de Wetering M, Clevers H, Spaargaren M, Pals ST. MET Signaling Mediates Intestinal Crypt-Villus Development, Regeneration, and Adenoma Formation and Is Promoted by Stem Cell CD44 Isoforms. Gastroenterology. PMID 28716720 DOI: 10.1053/j.gastro.2017.07.008  1
2017 Naxerova K, Reiter JG, Brachtel E, Lennerz JK, van de Wetering M, Rowan A, Cai T, Clevers H, Swanton C, Nowak MA, Elledge SJ, Jain RK. Origins of lymphatic and distant metastases in human colorectal cancer. Science (New York, N.Y.). 357: 55-60. PMID 28684519 DOI: 10.1126/science.aai8515  1
2017 Beumer J, Clevers H. How the Gut Feels, Smells, and Talks. Cell. 170: 10-11. PMID 28666112 DOI: 10.1016/j.cell.2017.06.023  1
2017 Andersson-Rolf A, Zilbauer M, Koo BK, Clevers H. Stem Cells in Repair of Gastrointestinal Epithelia. Physiology (Bethesda, Md.). 32: 278-289. PMID 28615312 DOI: 10.1152/physiol.00005.2017  1
2017 Kretzschmar K, Clevers H. Wnt/β-catenin signaling in adult mammalian epithelial stem cells. Developmental Biology. 428: 273-282. PMID 28526587 DOI: 10.1016/j.ydbio.2017.05.015  1
2017 Mizutani T, Tsukamoto Y, Clevers H. Oncogene-inducible organoids as a miniature platform to assess cancer characteristics. The Journal of Cell Biology. 216: 1505-1507. PMID 28512141 DOI: 10.1083/jcb.201704014  1
2017 Morcos MNF, Schoedel KB, Hoppe A, Behrendt R, Basak O, Clevers HC, Roers A, Gerbaulet A. SCA-1 Expression Level Identifies Quiescent Hematopoietic Stem and Progenitor Cells. Stem Cell Reports. 8: 1472-1478. PMID 28506535 DOI: 10.1016/j.stemcr.2017.04.012  1
2017 Bartfeld S, Clevers H. Stem cell-derived organoids and their application for medical research and patient treatment. Journal of Molecular Medicine (Berlin, Germany). 95: 729-738. PMID 28391362 DOI: 10.1007/s00109-017-1531-7  1
2017 Kruitwagen HS, Oosterhoff LA, Vernooij IG, Schrall IM, van Wolferen ME, Bannink F, Roesch C, van Uden L, Molenaar MR, Helms JB, Grinwis GC, Verstegen MM, van der Laan LJ, Huch M, Geijsen N, ... ... Clevers H, et al. Long-Term Adult Feline Liver Organoid Cultures for Disease Modeling of Hepatic Steatosis. Stem Cell Reports. PMID 28344000 DOI: 10.1016/j.stemcr.2017.02.015  1
2017 Dutta D, Heo I, Clevers H. Disease Modeling in Stem Cell-Derived 3D Organoid Systems. Trends in Molecular Medicine. PMID 28341301 DOI: 10.1016/j.molmed.2017.02.007  1
2017 Kretzschmar K, Clevers H. Everything has its time: Id2 clocks embryonic specification of Lgr5(+) gut stem cells. The Embo Journal. 36: 837-839. PMID 28298434 DOI: 10.15252/embj.201796482  1
2017 Sachs N, Tsukamoto Y, Kujala P, Peters PJ, Clevers H. Intestinal epithelial organoids fuse to form self-organizing tubes in floating collagen gels. Development (Cambridge, England). 144: 1107-1112. PMID 28292848 DOI: 10.1242/dev.143933  1
2017 Drost J, Clevers H. Translational applications of adult stem cell-derived organoids. Development (Cambridge, England). 144: 968-975. PMID 28292843 DOI: 10.1242/dev.140566  1
2017 Boj SF, Vonk AM, Statia M, Su J, Vries RR, Beekman JM, Clevers H. Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients. Journal of Visualized Experiments : Jove. PMID 28287550 DOI: 10.3791/55159  1
2017 Fumagalli A, Drost J, Suijkerbuijk SJ, van Boxtel R, de Ligt J, Offerhaus GJ, Begthel H, Beerling E, Tan EH, Sansom OJ, Cuppen E, Clevers H, van Rheenen J. Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids. Proceedings of the National Academy of Sciences of the United States of America. PMID 28270604 DOI: 10.1073/pnas.1701219114  1
2017 Tüysüz N, van Bloois L, van den Brink S, Begthel H, Verstegen MM, Cruz LJ, Hui L, van der Laan LJ, de Jonge J, Vries R, Braakman E, Mastrobattista E, Cornelissen JJ, Clevers H, Ten Berge D. Lipid-mediated Wnt protein stabilization enables serum-free culture of human organ stem cells. Nature Communications. 8: 14578. PMID 28262686 DOI: 10.1038/ncomms14578  1
2017 Driehuis E, Clevers H. WNT signaling events near the cell membrane and their pharmacological targeting for the treatment of cancer. British Journal of Pharmacology. PMID 28244067 DOI: 10.1111/bph.13758  1
2017 Öhlund D, Handly-Santana A, Biffi G, Elyada E, Almeida AS, Ponz-Sarvise M, Corbo V, Oni TE, Hearn SA, Lee EJ, Chio II, Hwang CI, Tiriac H, Baker LA, Engle DD, ... ... Clevers H, et al. Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer. The Journal of Experimental Medicine. PMID 28232471 DOI: 10.1084/jem.20162024  1
2017 Schneeberger K, Spee B, Costa P, Sachs N, Clevers H, Malda J. Converging biofabrication and organoid technologies: the next frontier in hepatic and intestinal tissue engineering? Biofabrication. PMID 28211365 DOI: 10.1088/1758-5090/aa6121  1
2017 Mahmoudi T, Boj SF, Hatzis P, Li VS, Taouatas N, Vries RG, Teunissen H, Begthel H, Korving J, Mohammed S, Heck AJ, Clevers H. Correction: The Leukemia-Associated Mllt10/Af10-Dot1l Are Tcf4/β-Catenin Coactivators Essential for Intestinal Homeostasis. Plos Biology. 15: e1002596. PMID 28170393 DOI: 10.1371/journal.pbio.1002596  1
2017 Driehuis E, Clevers H. CRISPR/Cas 9 genome editing and its applications in organoids. American Journal of Physiology. Gastrointestinal and Liver Physiology. 312: G257-G265. PMID 28126704 DOI: 10.1152/ajpgi.00410.2016  1
2017 Bredenoord AL, Clevers H, Knoblich JA. Human tissues in a dish: The research and ethical implications of organoid technology. Science (New York, N.Y.). 355. PMID 28104841 DOI: 10.1126/science.aaf9414  1
2017 Hombrink P, Helbig C, Backer RA, Piet B, Oja AE, Stark R, Brasser G, Jongejan A, Jonkers RE, Nota B, Basak O, Clevers HC, Moerland PD, Amsen D, van Lier RA. Erratum: Programs for the persistence, vigilance and control of human CD8(+) lung-resident memory T cells. Nature Immunology. 18: 246. PMID 28102212 DOI: 10.1038/ni0217-246d  1
2017 Cristobal A, van den Toorn HW, van de Wetering M, Clevers H, Heck AJ, Mohammed S. Personalized Proteome Profiles of Healthy and Tumor Human Colon Organoids Reveal Both Individual Diversity and Basic Features of Colorectal Cancer. Cell Reports. 18: 263-274. PMID 28052255 DOI: 10.1016/j.celrep.2016.12.016  1
2016 Basak O, Beumer J, Wiebrands K, Seno H, van Oudenaarden A, Clevers H. Induced Quiescence of Lgr5+ Stem Cells in Intestinal Organoids Enables Differentiation of Hormone-Producing Enteroendocrine Cells. Cell Stem Cell. PMID 27939219 DOI: 10.1016/j.stem.2016.11.001  1
2016 Steinhart Z, Pavlovic Z, Chandrashekhar M, Hart T, Wang X, Zhang X, Robitaille M, Brown KR, Jaksani S, Overmeer R, Boj SF, Adams J, Pan J, Clevers H, Sidhu S, et al. Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors. Nature Medicine. PMID 27869803 DOI: 10.1038/nm.4219  1
2016 Gjorevski N, Sachs N, Manfrin A, Giger S, Bragina ME, Ordóñez-Morán P, Clevers H, Lutolf MP. Designer matrices for intestinal stem cell and organoid culture. Nature. PMID 27851739 DOI: 10.1038/nature20168  1
2016 Verissimo CS, Overmeer RM, Ponsioen B, Drost J, Mertens S, Verlaan-Klink I, van Gerwen B, van der Ven M, Van de Wetering M, Egan DA, Bernards R, Clevers H, Bos JL, Snippert HJ. Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening. Elife. 5. PMID 27845624 DOI: 10.7554/eLife.18489  1
2016 Beumer J, Clevers H. Regulation and plasticity of intestinal stem cells during homeostasis and regeneration. Development (Cambridge, England). 143: 3639-3649. PMID 27802133 DOI: 10.1242/dev.133132  1
2016 Hombrink P, Helbig C, Backer RA, Piet B, Oja AE, Stark R, Brasser G, Jongejan A, Jonkers RE, Nota B, Basak O, Clevers HC, Moerland PD, Amsen D, van Lier RA. Programs for the persistence, vigilance and control of human CD8(+) lung-resident memory T cells. Nature Immunology. 17: 1467-1478. PMID 27776108 DOI: 10.1038/ni.3589  1
2016 Tetteh PW, Kretzschmar K, Begthel H, van den Born M, Korving J, Morsink F, Farin H, van Es JH, Offerhaus GJ, Clevers H. Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research. Proceedings of the National Academy of Sciences of the United States of America. 113: 11859-11864. PMID 27708166 DOI: 10.1073/pnas.1614057113  1
2016 Blokzijl F, de Ligt J, Jager M, Sasselli V, Roerink S, Sasaki N, Huch M, Boymans S, Kuijk E, Prins P, Nijman IJ, Martincorena I, Mokry M, Wiegerinck CL, Middendorp S, ... ... Clevers H, et al. Tissue-specific mutation accumulation in human adult stem cells during life. Nature. PMID 27698416 DOI: 10.1038/nature19768  1
2016 Daly CS, Shaw P, Ordonez LD, Williams GT, Quist J, Grigoriadis A, Van Es JH, Clevers H, Clarke AR, Reed KR. Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium. Oncogene. PMID 27694902 DOI: 10.1038/onc.2016.342  1
2016 Kretzschmar K, Clevers H. Organoids: Modeling Development and the Stem Cell Niche in a Dish. Developmental Cell. 38: 590-600. PMID 27676432 DOI: 10.1016/j.devcel.2016.08.014  0.01
2016 Drost J, Artegiani B, Clevers H. The Generation of Organoids for Studying Wnt Signaling. Methods in Molecular Biology (Clifton, N.J.). 1481: 141-59. PMID 27590160 DOI: 10.1007/978-1-4939-6393-5_15  1
2016 Sasaki N, Sachs N, Wiebrands K, Ellenbroek SI, Fumagalli A, Lyubimova A, Begthel H, van den Born M, van Es JH, Karthaus WR, Li VS, López-Iglesias C, Peters PJ, van Rheenen J, van Oudenaarden A, ... Clevers H, et al. Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon. Proceedings of the National Academy of Sciences of the United States of America. PMID 27573849 DOI: 10.1073/pnas.1607327113  1
2016 Broutier L, Andersson-Rolf A, Hindley CJ, Boj SF, Clevers H, Koo BK, Huch M. Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation. Nature Protocols. 11: 1724-43. PMID 27560176 DOI: 10.1038/nprot.2016.097  1
2016 Cammareri P, Rose AM, Vincent DF, Wang J, Nagano A, Libertini S, Ridgway RA, Athineos D, Coates PJ, McHugh A, Pourreyron C, Dayal JH, Larsson J, Weidlich S, Spender LC, ... ... Clevers H, et al. Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma. Nature Communications. 7: 12493. PMID 27558455 DOI: 10.1038/ncomms12493  1
2016 Drost J, Clevers H. Who Is in the Driver's Seat: Tracing Cancer Genes Using CRISPR-Barcoding. Molecular Cell. 63: 352-4. PMID 27494556 DOI: 10.1016/j.molcel.2016.07.013  1
2016 Grün D, Muraro MJ, Boisset JC, Wiebrands K, Lyubimova A, Dharmadhikari G, van den Born M, van Es J, Jansen E, Clevers H, de Koning EJ, van Oudenaarden A. De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data. Cell Stem Cell. PMID 27345837 DOI: 10.1016/j.stem.2016.05.010  1
2016 Dekkers JF, Berkers G, Kruisselbrink E, Vonk A, de Jonge HR, Janssens HM, Bronsveld I, van de Graaf EA, Nieuwenhuis EE, Houwen RH, Vleggaar FP, Escher JC, de Rijke YB, Majoor CJ, Heijerman HG, ... ... Clevers H, et al. Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis. Science Translational Medicine. 8: 344ra84. PMID 27334259 DOI: 10.1126/scitranslmed.aad8278  1
2016 Yan HH, Lai JC, Ho SL, Leung WK, Law WL, Lee JF, Chan AK, Tsui WY, Chan AS, Lee BC, Yue SS, Man AH, Clevers H, Yuen ST, Leung SY. RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation. Gut. PMID 27329244 DOI: 10.1136/gutjnl-2016-311849  1
2016 Clevers H. Modeling Development and Disease with Organoids. Cell. 165: 1586-1597. PMID 27315476 DOI: 10.1016/j.cell.2016.05.082  0.01
2016 Boj SF, Hwang CI, Baker LA, Engle DD, Tuveson DA, Clevers H. Model organoids provide new research opportunities for ductal pancreatic cancer. Molecular & Cellular Oncology. 3: e1014757. PMID 27308531 DOI: 10.1080/23723556.2015.1014757  1
2016 Boers SN, van Delden JJ, Clevers H, Bredenoord AL. Organoid biobanking: identifying the ethics: Organoids revive old and raise new ethical challenges for basic research and therapeutic use. Embo Reports. 17: 938-41. PMID 27296278 DOI: 10.15252/embr.201642613  1
2016 Schwank G, Clevers H. CRISPR/Cas9-Mediated Genome Editing of Mouse Small Intestinal Organoids. Methods in Molecular Biology (Clifton, N.J.). 1422: 3-11. PMID 27246017 DOI: 10.1007/978-1-4939-3603-8_1  0.01
2016 Fessler E, Drost J, van Hooff SR, Linnekamp JF, Wang X, Jansen M, De Sousa E Melo F, Prasetyanti PR, IJspeert JE, Franitza M, Nürnberg P, van Noesel CJ, Dekker E, Vermeulen L, Clevers H, et al. TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype. Embo Molecular Medicine. PMID 27221051 DOI: 10.15252/emmm.201606184  1
2016 Dominguez-Brauer C, Hao Z, Elia AJ, Fortin JM, Nechanitzky R, Brauer PM, Sheng Y, Mana MD, Chio II, Haight J, Pollett A, Cairns R, Tworzyanski L, Inoue S, Reardon C, ... ... Clevers H, et al. Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation. Cell Stem Cell. PMID 27184401 DOI: 10.1016/j.stem.2016.04.002  1
2016 Baker LA, Tiriac H, Clevers H, Tuveson DA. Modeling pancreatic cancer with organoids. Trends in Cancer. 2: 176-190. PMID 27135056 DOI: 10.1016/j.trecan.2016.03.004  1
2016 Zhao C, Deng Y, Liu L, Yu K, Zhang L, Wang H, He X, Wang J, Lu C, Wu LN, Weng Q, Mao M, Li J, van Es JH, Xin M, ... ... Clevers H, et al. Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation. Nature Communications. 7: 10883. PMID 26955760 DOI: 10.1038/ncomms10883  1
2016 Kuijk EW, Rasmussen S, Blokzijl F, Huch M, Gehart H, Toonen P, Begthel H, Clevers H, Geurts AM, Cuppen E. Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure. Scientific Reports. 6: 22154. PMID 26915950 DOI: 10.1038/srep22154  1
2016 Farin HF, Jordens I, Mosa MH, Basak O, Korving J, Tauriello DV, de Punder K, Angers S, Peters PJ, Maurice MM, Clevers H. Visualization of a short-range Wnt gradient in the intestinal stem-cell niche. Nature. PMID 26863187 DOI: 10.1038/nature16937  1
2016 Tetteh PW, Basak O, Farin HF, Wiebrands K, Kretzschmar K, Begthel H, van den Born M, Korving J, de Sauvage F, van Es JH, van Oudenaarden A, Clevers H. Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters. Cell Stem Cell. 18: 203-13. PMID 26831517 DOI: 10.1016/j.stem.2016.01.001  1
2016 Drost J, Karthaus WR, Gao D, Driehuis E, Sawyers CL, Chen Y, Clevers H. Organoid culture systems for prostate epithelial and cancer tissue. Nature Protocols. 11: 347-58. PMID 26797458 DOI: 10.1038/nprot.2016.006  1
2016 Karin M, Clevers H. Reparative inflammation takes charge of tissue regeneration. Nature. 529: 307-15. PMID 26791721 DOI: 10.1038/nature17039  1
2016 Maimets M, Rocchi C, Bron R, Pringle S, Kuipers J, Giepmans BN, Vries RG, Clevers H, de Haan G, van Os R, Coppes RP. Long-Term In Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals. Stem Cell Reports. 6: 150-62. PMID 26724906 DOI: 10.1016/j.stemcr.2015.11.009  1
2016 Maimets M, Rocchi C, Bron R, Pringle S, Kuipers J, Giepmans BNG, Vries RGJ, Clevers H, De Haan G, Van Os R, Coppes RP. Long-Term in Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals Stem Cell Reports. 6: 150-162. DOI: 10.1016/j.stemcr.2015.11.009  1
2015 Bartfeld S, Clevers H. Organoids as Model for Infectious Diseases: Culture of Human and Murine Stomach Organoids and Microinjection of Helicobacter Pylori. Journal of Visualized Experiments : Jove. PMID 26650279 DOI: 10.3791/53359  1
2015 Agarwal S, Hynes PG, Tillman HS, Lake R, Abou-Kheir WG, Fang L, Casey OM, Ameri AH, Martin PL, Yin JJ, Iaquinta PJ, Karthaus WR, Clevers HC, Sawyers CL, Kelly K. Identification of Different Classes of Luminal Progenitor Cells within Prostate Tumors. Cell Reports. 13: 2147-58. PMID 26628377 DOI: 10.1016/j.celrep.2015.10.077  1
2015 Füllgrabe A, Joost S, Are A, Jacob T, Sivan U, Haegebarth A, Linnarsson S, Simons BD, Clevers H, Toftgård R, Kasper M. Dynamics of Lgr6(+) Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis. Stem Cell Reports. PMID 26607954 DOI: 10.1016/j.stemcr.2015.09.013  1
2015 Kabouridis PS, Lasrado R, McCallum S, Chng SH, Snippert HJ, Clevers H, Pettersson S, Pachnis V. The gut microbiota keeps enteric glial cells on the move; prospective roles of the gut epithelium and immune system. Gut Microbes. 0. PMID 26558327 DOI: 10.1080/19490976.2015.1109767  1
2015 Weeber F, van de Wetering M, Hoogstraat M, Dijkstra KK, Krijgsman O, Kuilman T, Gadellaa-van Hooijdonk CG, van der Velden DL, Peeper DS, Cuppen EP, Vries RG, Clevers H, Voest EE. Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases. Proceedings of the National Academy of Sciences of the United States of America. 112: 13308-11. PMID 26460009 DOI: 10.1073/pnas.1516689112  1
2015 Nantasanti S, Spee B, Kruitwagen HS, Chen C, Geijsen N, Oosterhoff LA, van Wolferen ME, Pelaez N, Fieten H, Wubbolts RW, Grinwis GC, Chan J, Huch M, Vries RR, Clevers H, et al. Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids. Stem Cell Reports. PMID 26455412 DOI: 10.1016/j.stemcr.2015.09.002  1
2015 Hwang CI, Boj SF, Clevers H, Tuveson DA. Pre-clinical Models of Pancreatic Ductal Adenocarcinoma. The Journal of Pathology. PMID 26419819 DOI: 10.1002/path.4651  1
2015 Schneeberger K, Vogel GF, Teunissen H, van Ommen DD, Begthel H, El Bouazzaoui L, van Vugt AH, Beekman JM, Klumperman J, Müller T, Janecke A, Gerner P, Huber LA, Hess MW, Clevers H, et al. An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral trafficking. Proceedings of the National Academy of Sciences of the United States of America. PMID 26392529 DOI: 10.1073/pnas.1516672112  1
2015 Grün D, Lyubimova A, Kester L, Wiebrands K, Basak O, Sasaki N, Clevers H, van Oudenaarden A. Single-cell messenger RNA sequencing reveals rare intestinal cell types. Nature. 525: 251-5. PMID 26287467 DOI: 10.1038/nature14966  1
2015 Rookmaaker MB, Schutgens F, Verhaar MC, Clevers H. Development and application of human adult stem or progenitor cell organoids. Nature Reviews. Nephrology. 11: 546-54. PMID 26215513 DOI: 10.1038/nrneph.2015.118  0.01
2015 Heo I, Clevers H. Expanding intestinal stem cells in culture. Cell Research. 25: 995-6. PMID 26169607 DOI: 10.1038/cr.2015.83  1
2015 Sato T, Clevers H. SnapShot: Growing Organoids from Stem Cells. Cell. 161: 1700-1700.e1. PMID 26091044 DOI: 10.1016/j.cell.2015.06.028  0.01
2015 Dow LE, O'Rourke KP, Simon J, Tschaharganeh DF, van Es JH, Clevers H, Lowe SW. Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer. Cell. 161: 1539-52. PMID 26091037 DOI: 10.1016/j.cell.2015.05.033  1
2015 Koo BK, van Es JH, van den Born M, Clevers H. Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia. Proceedings of the National Academy of Sciences of the United States of America. 112: 7548-50. PMID 26023187 DOI: 10.1073/pnas.1508113112  1
2015 van de Wetering M, Francies HE, Francis JM, Bounova G, Iorio F, Pronk A, van Houdt W, van Gorp J, Taylor-Weiner A, Kester L, McLaren-Douglas A, Blokker J, Jaksani S, Bartfeld S, Volckman R, ... ... Clevers H, et al. Prospective derivation of a living organoid biobank of colorectal cancer patients. Cell. 161: 933-45. PMID 25957691 DOI: 10.1016/j.cell.2015.03.053  1
2015 Drost J, van Jaarsveld RH, Ponsioen B, Zimberlin C, van Boxtel R, Buijs A, Sachs N, Overmeer RM, Offerhaus GJ, Begthel H, Korving J, van de Wetering M, Schwank G, Logtenberg M, Cuppen E, ... ... Clevers H, et al. Sequential cancer mutations in cultured human intestinal stem cells. Nature. 521: 43-7. PMID 25924068 DOI: 10.1038/nature14415  1
2015 D'Astolfo DS, Pagliero RJ, Pras A, Karthaus WR, Clevers H, Prasad V, Lebbink RJ, Rehmann H, Geijsen N. Efficient intracellular delivery of native proteins. Cell. 161: 674-90. PMID 25910214 DOI: 10.1016/j.cell.2015.03.028  1
2015 Flanagan DJ, Phesse TJ, Barker N, Schwab RH, Amin N, Malaterre J, Stange DE, Nowell CJ, Currie SA, Saw JT, Beuchert E, Ramsay RG, Sansom OJ, Ernst M, Clevers H, et al. Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5(+) stem cells. Stem Cell Reports. 4: 759-67. PMID 25892522 DOI: 10.1016/j.stemcr.2015.03.003  1
2015 Kundu P, Genander M, Strååt K, Classon J, Ridgway RA, Tan EH, Björk J, Martling A, van Es J, Sansom OJ, Clevers H, Pettersson S, Frisén J. An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth. Science Translational Medicine. 7: 281ra44. PMID 25834110 DOI: 10.1126/scitranslmed.3010567  1
2015 Baggiolini A, Varum S, Mateos JM, Bettosini D, John N, Bonalli M, Ziegler U, Dimou L, Clevers H, Furrer R, Sommer L. Premigratory and migratory neural crest cells are multipotent in vivo. Cell Stem Cell. 16: 314-22. PMID 25748934 DOI: 10.1016/j.stem.2015.02.017  1
2015 Weren RD, Venkatachalam R, Cazier JB, Farin HF, Kets CM, de Voer RM, Vreede L, Verwiel ET, van Asseldonk M, Kamping EJ, Kiemeney LA, Neveling K, Aben KK, Carvajal-Carmona L, Nagtegaal ID, ... ... Clevers H, et al. Germline deletions in the tumour suppressor gene FOCAD are associated with polyposis and colorectal cancer development. The Journal of Pathology. 236: 155-64. PMID 25712196 DOI: 10.1002/path.4520  1
2015 van Es JH, Clevers H. Generation and analysis of mouse intestinal tumors and organoids harboring APC and K-Ras mutations. Methods in Molecular Biology (Clifton, N.J.). 1267: 125-44. PMID 25636467 DOI: 10.1007/978-1-4939-2297-0_6  1
2015 Schuijers J, Junker JP, Mokry M, Hatzis P, Koo BK, Sasselli V, van der Flier LG, Cuppen E, van Oudenaarden A, Clevers H. Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts. Cell Stem Cell. 16: 158-70. PMID 25620640 DOI: 10.1016/j.stem.2014.12.006  1
2015 Kabouridis PS, Lasrado R, McCallum S, Chng SH, Snippert HJ, Clevers H, Pettersson S, Pachnis V. Microbiota controls the homeostasis of glial cells in the gut lamina propria. Neuron. 85: 289-95. PMID 25578362 DOI: 10.1016/j.neuron.2014.12.037  1
2015 Boj SF, Hwang CI, Baker LA, Chio II, Engle DD, Corbo V, Jager M, Ponz-Sarvise M, Tiriac H, Spector MS, Gracanin A, Oni T, Yu KH, van Boxtel R, Huch M, ... ... Clevers H, et al. Organoid models of human and mouse ductal pancreatic cancer. Cell. 160: 324-38. PMID 25557080 DOI: 10.1016/j.cell.2014.12.021  1
2015 Huch M, Gehart H, van Boxtel R, Hamer K, Blokzijl F, Verstegen MM, Ellis E, van Wenum M, Fuchs SA, de Ligt J, van de Wetering M, Sasaki N, Boers SJ, Kemperman H, de Jonge J, ... ... Clevers H, et al. Long-term culture of genome-stable bipotent stem cells from adult human liver. Cell. 160: 299-312. PMID 25533785 DOI: 10.1016/j.cell.2014.11.050  1
2015 Petersen N, Reimann F, van Es JH, van den Berg BM, Kroone C, Pais R, Jansen E, Clevers H, Gribble FM, de Koning EJ. Targeting development of incretin-producing cells increases insulin secretion. The Journal of Clinical Investigation. 125: 379-85. PMID 25500886 DOI: 10.1172/JCI75838  1
2014 Simmini S, Bialecka M, Huch M, Kester L, van de Wetering M, Sato T, Beck F, van Oudenaarden A, Clevers H, Deschamps J. Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2. Nature Communications. 5: 5728. PMID 25500896 DOI: 10.1038/ncomms6728  1
2014 Vermunt MW, Reinink P, Korving J, de Bruijn E, Creyghton PM, Basak O, Geeven G, Toonen PW, Lansu N, Meunier C, van Heesch S, Clevers H, de Laat W, Cuppen E, Creyghton MP. Large-scale identification of coregulated enhancer networks in the adult human brain Cell Reports. 9: 767-779. PMID 25373911 DOI: 10.1016/j.celrep.2014.09.023  1
2014 Clevers H, Loh KM, Nusse R. Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control. Science (New York, N.Y.). 346: 1248012. PMID 25278615 DOI: 10.1126/science.1248012  1
2014 Vereecke L, Vieira-Silva S, Billiet T, van Es JH, Mc Guire C, Slowicka K, Sze M, van den Born M, De Hertogh G, Clevers H, Raes J, Rutgeerts P, Vermeire S, Beyaert R, van Loo G. A20 controls intestinal homeostasis through cell-specific activities. Nature Communications. 5: 5103. PMID 25267258 DOI: 10.1038/ncomms6103  1
2014 Bolden JE, Tasdemir N, Dow LE, van Es JH, Wilkinson JE, Zhao Z, Clevers H, Lowe SW. Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition. Cell Reports. 8: 1919-29. PMID 25242322 DOI: 10.1016/j.celrep.2014.08.025  1
2014 Gao D, Vela I, Sboner A, Iaquinta PJ, Karthaus WR, Gopalan A, Dowling C, Wanjala JN, Undvall EA, Arora VK, Wongvipat J, Kossai M, Ramazanoglu S, Barboza LP, Di W, ... ... Clevers H, et al. Organoid cultures derived from patients with advanced prostate cancer. Cell. 159: 176-87. PMID 25201530 DOI: 10.1016/j.cell.2014.08.016  1
2014 Karthaus WR, Iaquinta PJ, Drost J, Gracanin A, van Boxtel R, Wongvipat J, Dowling CM, Gao D, Begthel H, Sachs N, Vries RG, Cuppen E, Chen Y, Sawyers CL, Clevers HC. Identification of multipotent luminal progenitor cells in human prostate organoid cultures. Cell. 159: 163-75. PMID 25201529 DOI: 10.1016/j.cell.2014.08.017  1
2014 Lemoine R, Pachlopnik-Schmid J, Farin HF, Bigorgne A, Debré M, Sepulveda F, Héritier S, Lemale J, Talbotec C, Rieux-Laucat F, Ruemmele F, Morali A, Cathebras P, Nitschke P, Bole-Feysot C, ... ... Clevers H, et al. Immune deficiency-related enteropathy-lymphocytopenia-alopecia syndrome results from tetratricopeptide repeat domain 7A deficiency. The Journal of Allergy and Clinical Immunology. 134: 1354-1364.e6. PMID 25174867 DOI: 10.1016/j.jaci.2014.07.019  1
2014 Basak O, van de Born M, Korving J, Beumer J, van der Elst S, van Es JH, Clevers H. Mapping early fate determination in Lgr5+ crypt stem cells using a novel Ki67-RFP allele. The Embo Journal. 33: 2057-68. PMID 25092767 DOI: 10.15252/embj.201488017  1
2014 Kaukua N, Shahidi MK, Konstantinidou C, Dyachuk V, Kaucka M, Furlan A, An Z, Wang L, Hultman I, Ahrlund-Richter L, Blom H, Brismar H, Lopes NA, Pachnis V, Suter U, ... Clevers H, et al. Glial origin of mesenchymal stem cells in a tooth model system. Nature. 513: 551-4. PMID 25079316 DOI: 10.1038/nature13536  1
2014 Behjati S, Huch M, van Boxtel R, Karthaus W, Wedge DC, Tamuri AU, Martincorena I, Petljak M, Alexandrov LB, Gundem G, Tarpey PS, Roerink S, Blokker J, Maddison M, Mudie L, ... ... Clevers H, et al. Genome sequencing of normal cells reveals developmental lineages and mutational processes. Nature. 513: 422-5. PMID 25043003 DOI: 10.1038/nature13448  1
2014 Liu D, He XC, Qian P, Barker N, Trainor PA, Clevers H, Liu H, Li L. Leucine-rich repeat-containing G-protein-coupled Receptor 5 marks short-term hematopoietic stem and progenitor cells during mouse embryonic development. The Journal of Biological Chemistry. 289: 23809-16. PMID 24966324 DOI: 10.1074/jbc.M114.568170  1
2014 Forster R, Chiba K, Schaeffer L, Regalado SG, Lai CS, Gao Q, Kiani S, Farin HF, Clevers H, Cost GJ, Chan A, Rebar EJ, Urnov FD, Gregory PD, Pachter L, et al. Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells. Stem Cell Reports. 2: 838-52. PMID 24936470 DOI: 10.1016/j.stemcr.2014.05.001  1
2014 Clevers JC. [Stop the compulsive PhD trajectory for junior doctors]. Nederlands Tijdschrift Voor Geneeskunde. 158: A7669. PMID 24893817  0.48
2014 Koo BK, Clevers H. Stem cells marked by the r-spondin receptor LGR5 Gastroenterology. 147: 289-302. PMID 24859206 DOI: 10.1053/j.gastro.2014.05.007  1
2014 Wang K, Yuen ST, Xu J, Lee SP, Yan HH, Shi ST, Siu HC, Deng S, Chu KM, Law S, Chan KH, Chan AS, Tsui WY, Ho SL, Chan AK, ... ... Clevers H, et al. Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer. Nature Genetics. 46: 573-82. PMID 24816253 DOI: 10.1038/ng.2983  1
2014 Wiegerinck CL, Janecke AR, Schneeberger K, Vogel GF, van Haaften-Visser DY, Escher JC, Adam R, Thöni CE, Pfaller K, Jordan AJ, Weis CA, Nijman IJ, Monroe GR, van Hasselt PM, Cutz E, ... ... Clevers H, et al. Loss of syntaxin 3 causes variant microvillus inclusion disease. Gastroenterology. 147: 65-68.e10. PMID 24726755 DOI: 10.1053/j.gastro.2014.04.002  1
2014 Verhaegh W, Van Ooijen H, Inda MA, Hatzis P, Versteeg R, Smid M, Martens J, Foekens J, Van De Wiel P, Clevers H, Van De Stolpe A. Selection of personalized patient therapy through the use of knowledge-based computational models that identify tumor-driving signal transduction pathways Cancer Research. 74: 2936-2945. PMID 24695361 DOI: 10.1158/0008-5472.CAN-13-2515  1
2014 Forrest AR, Kawaji H, Rehli M, Baillie JK, de Hoon MJ, Haberle V, Lassmann T, Kulakovskiy IV, Lizio M, Itoh M, Andersson R, Mungall CJ, Meehan TF, Schmeier S, ... ... Clevers HC, et al. A promoter-level mammalian expression atlas. Nature. 507: 462-70. PMID 24670764 DOI: 10.1038/nature13182  1
2014 Nakaya T, Ogawa S, Manabe I, Tanaka M, Sanada M, Sato T, Taketo MM, Nakao K, Clevers H, Fukayama M, Kuroda M, Nagai R. KLF5 regulates the integrity and oncogenicity of intestinal stem cells. Cancer Research. 74: 2882-91. PMID 24626089 DOI: 10.1158/0008-5472.CAN-13-2574  1
2014 Veleva-Rotse BO, Smart JL, Baas AF, Edmonds B, Zhao ZM, Brown A, Klug LR, Hansen K, Reilly G, Gardner AP, Subbiah K, Gaucher EA, Clevers H, Barnes AP. STRAD pseudokinases regulate axogenesis and LKB1 stability. Neural Development. 9: 5. PMID 24594058 DOI: 10.1186/1749-8104-9-5  1
2014 de Lau W, Peng WC, Gros P, Clevers H. The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength. Genes & Development. 28: 305-16. PMID 24532711 DOI: 10.1101/gad.235473.113  1
2014 Ritsma L, Ellenbroek SI, Zomer A, Snippert HJ, de Sauvage FJ, Simons BD, Clevers H, van Rheenen J. Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging. Nature. 507: 362-5. PMID 24531760 DOI: 10.1038/nature12972  1
2014 Sun X, Terakawa J, Clevers H, Barker N, Daikoku T, Dey SK. Ovarian LGR5 is critical for successful pregnancy. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 2380-9. PMID 24469993 DOI: 10.1096/fj.13-248344  1
2014 Snippert HJ, Schepers AG, van Es JH, Simons BD, Clevers H. Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion. Embo Reports. 15: 62-9. PMID 24355609 DOI: 10.1002/embr.201337799  1
2014 Mokry M, Middendorp S, Wiegerinck CL, Witte M, Teunissen H, Meddens CA, Cuppen E, Clevers H, Nieuwenhuis EE. Many inflammatory bowel disease risk loci include regions that regulate gene expression in immune cells and the intestinal epithelium. Gastroenterology. 146: 1040-7. PMID 24333384 DOI: 10.1053/j.gastro.2013.12.003  1
2014 Bigorgne AE, Farin HF, Lemoine R, Mahlaoui N, Lambert N, Gil M, Schulz A, Philippet P, Schlesser P, Abrahamsen TG, Oymar K, Davies EG, Ellingsen CL, Leteurtre E, Moreau-Massart B, ... ... Clevers H, et al. TTC7A mutations disrupt intestinal epithelial apicobasal polarity. The Journal of Clinical Investigation. 124: 328-37. PMID 24292712 DOI: 10.1172/JCI71471  1
2014 Yin X, Farin HF, van Es JH, Clevers H, Langer R, Karp JM. Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny. Nature Methods. 11: 106-12. PMID 24292484 DOI: 10.1038/nmeth.2737  1
2014 Hirsch D, Barker N, McNeil N, Hu Y, Camps J, McKinnon K, Clevers H, Ried T, Gaiser T. LGR5 positivity defines stem-like cells in colorectal cancer. Carcinogenesis. 35: 849-58. PMID 24282287 DOI: 10.1093/carcin/bgt377  1
2014 Petersen N, Reimann F, Bartfeld S, Farin HF, Ringnalda FC, Vries RG, van den Brink S, Clevers H, Gribble FM, de Koning EJ. Generation of L cells in mouse and human small intestine organoids. Diabetes. 63: 410-20. PMID 24130334 DOI: 10.2337/db13-0991  1
2014 Fischer JM, Schepers AG, Clevers H, Shibata D, Liskay RM. Occult progression by Apc-deficient intestinal crypts as a target for chemoprevention. Carcinogenesis. 35: 237-46. PMID 23996931 DOI: 10.1093/carcin/bgt296  1
2014 Zeilstra J, Joosten SP, van Andel H, Tolg C, Berns A, Snoek M, van de Wetering M, Spaargaren M, Clevers H, Pals ST. Stem cell CD44v isoforms promote intestinal cancer formation in Apc(min) mice downstream of Wnt signaling. Oncogene. 33: 665-70. PMID 23318432 DOI: 10.1038/onc.2012.611  1
2013 Peng WC, de Lau W, Madoori PK, Forneris F, Granneman JC, Clevers H, Gros P. Structures of Wnt-antagonist ZNRF3 and its complex with R-spondin 1 and implications for signaling. Plos One. 8: e83110. PMID 24349440 DOI: 10.1371/journal.pone.0083110  1
2013 Schwank G, Koo BK, Sasselli V, Dekkers JF, Heo I, Demircan T, Sasaki N, Boymans S, Cuppen E, van der Ent CK, Nieuwenhuis EE, Beekman JM, Clevers H. Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell Stem Cell. 13: 653-8. PMID 24315439 DOI: 10.1016/j.stem.2013.11.002  1
2013 Schwank G, Andersson-Rolf A, Koo BK, Sasaki N, Clevers H. Generation of BAC transgenic epithelial organoids. Plos One. 8: e76871. PMID 24204693 DOI: 10.1371/journal.pone.0076871  1
2013 de Groot RE, Farin HF, Macůrková M, van Es JH, Clevers HC, Korswagen HC. Retromer dependent recycling of the Wnt secretion factor Wls is dispensable for stem cell maintenance in the mammalian intestinal epithelium. Plos One. 8: e76971. PMID 24130821 DOI: 10.1371/journal.pone.0076971  1
2013 Stange DE, Koo BK, Huch M, Sibbel G, Basak O, Lyubimova A, Kujala P, Bartfeld S, Koster J, Geahlen JH, Peters PJ, Van Es JH, Van De Wetering M, Mills JC, Clevers H. XDifferentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium Cell. 155. PMID 24120136 DOI: 10.1016/j.cell.2013.09.008  1
2013 Huch M, Bonfanti P, Boj SF, Sato T, Loomans CJ, van de Wetering M, Sojoodi M, Li VS, Schuijers J, Gracanin A, Ringnalda F, Begthel H, Hamer K, Mulder J, van Es JH, ... ... Clevers H, et al. Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis. The Embo Journal. 32: 2708-21. PMID 24045232 DOI: 10.1038/emboj.2013.204  1
2013 Sone M, Oyama K, Mohri Y, Hayashi R, Clevers H, Nishimori K. LGR4 expressed in uterine epithelium is necessary for uterine gland development and contributes to decidualization in mice Faseb Journal. 27: 4917-4928. PMID 23975934 DOI: 10.1096/fj.13-232215  1
2013 Pilz GA, Shitamukai A, Reillo I, Pacary E, Schwausch J, Stahl R, Ninkovic J, Snippert HJ, Clevers H, Godinho L, Guillemot F, Borrell V, Matsuzaki F, Götz M. Amplification of progenitors in the mammalian telencephalon includes a new radial glial cell type. Nature Communications. 4: 2125. PMID 23839311 DOI: 10.1038/ncomms3125  1
2013 Peng WC, de Lau W, Forneris F, Granneman JC, Huch M, Clevers H, Gros P. Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5. Cell Reports. 3: 1885-92. PMID 23809763 DOI: 10.1016/j.celrep.2013.06.009  1
2013 Dekkers JF, Wiegerinck CL, de Jonge HR, Bronsveld I, Janssens HM, de Winter-de Groot KM, Brandsma AM, de Jong NW, Bijvelds MJ, Scholte BJ, Nieuwenhuis EE, van den Brink S, Clevers H, van der Ent CK, Middendorp S, et al. A functional CFTR assay using primary cystic fibrosis intestinal organoids. Nature Medicine. 19: 939-45. PMID 23727931 DOI: 10.1038/nm.3201  1
2013 Kaaij LT, van de Wetering M, Fang F, Decato B, Molaro A, van de Werken HJ, van Es JH, Schuijers J, de Wit E, de Laat W, Hannon GJ, Clevers HC, Smith AD, Ketting RF. DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus. Genome Biology. 14: R50. PMID 23714178 DOI: 10.1186/gb-2013-14-5-r50  1
2013 Marko CK, Menon BB, Chen G, Whitsett JA, Clevers H, Gipson IK. Spdef null mice lack conjunctival goblet cells and provide a model of dry eye. The American Journal of Pathology. 183: 35-48. PMID 23665202 DOI: 10.1016/j.ajpath.2013.03.017  1
2013 Bianco P, Barker R, Brüstle O, Cattaneo E, Clevers H, Daley GQ, De Luca M, Goldstein L, Lindvall O, Mummery C, Robey PG, Sattler de Sousa E Brito C, Smith A. Regulation of stem cell therapies under attack in Europe: for whom the bell tolls. The Embo Journal. 32: 1489-95. PMID 23644381 DOI: 10.1038/emboj.2013.114  1
2013 Lu J, Zhang S, Nakano H, Simmons DG, Wang S, Kong S, Wang Q, Shen L, Tu Z, Wang W, Wang B, Wang H, Wang Y, van Es JH, Clevers H, et al. A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta. Plos Biology. 11: e1001536. PMID 23610556 DOI: 10.1371/journal.pbio.1001536  1
2013 Heijmans J, van Lidth de Jeude JF, Koo BK, Rosekrans SL, Wielenga MC, van de Wetering M, Ferrante M, Lee AS, Onderwater JJ, Paton JC, Paton AW, Mommaas AM, Kodach LL, Hardwick JC, Hommes DW, ... Clevers H, et al. ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response. Cell Reports. 3: 1128-39. PMID 23545496 DOI: 10.1016/j.celrep.2013.02.031  1
2013 Bardehle S, Krüger M, Buggenthin F, Schwausch J, Ninkovic J, Clevers H, Snippert HJ, Theis FJ, Meyer-Luehmann M, Bechmann I, Dimou L, Götz M. Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation. Nature Neuroscience. 16: 580-6. PMID 23542688 DOI: 10.1038/nn.3371  1
2013 Clevers HC, Bevins CL. Paneth cells: maestros of the small intestinal crypts. Annual Review of Physiology. 75: 289-311. PMID 23398152 DOI: 10.1146/annurev-physiol-030212-183744  0.08
2013 Huch M, Dorrell C, Boj SF, van Es JH, Li VS, van de Wetering M, Sato T, Hamer K, Sasaki N, Finegold MJ, Haft A, Vries RG, Grompe M, Clevers H. In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature. 494: 247-50. PMID 23354049 DOI: 10.1038/nature11826  1
2012 Boj SF, van Es JH, Huch M, Li VS, José A, Hatzis P, Mokry M, Haegebarth A, van den Born M, Chambon P, Voshol P, Dor Y, Cuppen E, Fillat C, Clevers H. Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell. 151: 1595-607. PMID 23260145 DOI: 10.1016/j.cell.2012.10.053  1
2012 Tiemessen MM, Baert MR, Schonewille T, Brugman MH, Famili F, Salvatori DC, Meijerink JP, Ozbek U, Clevers H, van Dongen JJ, Staal FJ. The nuclear effector of Wnt-signaling, Tcf1, functions as a T-cell-specific tumor suppressor for development of lymphomas. Plos Biology. 10: e1001430. PMID 23185135 DOI: 10.1371/journal.pbio.1001430  1
2012 Staal FJ, Clevers H. Tales of the unexpected: Tcf1 functions as a tumor suppressor for leukemias. Immunity. 37: 761-3. PMID 23159221 DOI: 10.1016/j.immuni.2012.10.008  1
2012 Barker N, van Oudenaarden A, Clevers H. Identifying the stem cell of the intestinal crypt: strategies and pitfalls. Cell Stem Cell. 11: 452-60. PMID 23040474 DOI: 10.1016/j.stem.2012.09.009  1
2012 van Es JH, Sato T, van de Wetering M, Lyubimova A, Nee AN, Gregorieff A, Sasaki N, Zeinstra L, van den Born M, Korving J, Martens AC, Barker N, van Oudenaarden A, Clevers H. Dll1+ secretory progenitor cells revert to stem cells upon crypt damage. Nature Cell Biology. 14: 1099-104. PMID 23000963 DOI: 10.1038/ncb2581  1
2012 Kemper K, Prasetyanti PR, De Lau W, Rodermond H, Clevers H, Medema JP. Monoclonal antibodies against Lgr5 identify human colorectal cancer stem cells Stem Cells. 30: 2378-2386. PMID 22969042 DOI: 10.1002/stem.1233  1
2012 de Visser KE, Ciampricotti M, Michalak EM, Tan DW, Speksnijder EN, Hau CS, Clevers H, Barker N, Jonkers J. Developmental stage-specific contribution of LGR5(+) cells to basal and luminal epithelial lineages in the postnatal mammary gland. The Journal of Pathology. 228: 300-9. PMID 22926799 DOI: 10.1002/path.4096  1
2012 Koo BK, Spit M, Jordens I, Low TY, Stange DE, van de Wetering M, van Es JH, Mohammed S, Heck AJ, Maurice MM, Clevers H. Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors. Nature. 488: 665-9. PMID 22895187 DOI: 10.1038/nature11308  1
2012 Shaked H, Hofseth LJ, Chumanevich A, Chumanevich AA, Wang J, Wang Y, Taniguchi K, Guma M, Shenouda S, Clevers H, Harris CC, Karin M. Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation. Proceedings of the National Academy of Sciences of the United States of America. 109: 14007-12. PMID 22893683 DOI: 10.1073/pnas.1211509109  1
2012 Schepers AG, Snippert HJ, Stange DE, van den Born M, van Es JH, van de Wetering M, Clevers H. Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Science (New York, N.Y.). 337: 730-5. PMID 22855427 DOI: 10.1126/science.1224676  1
2012 Hashimoto T, Perlot T, Rehman A, Trichereau J, Ishiguro H, Paolino M, Sigl V, Hanada T, Hanada R, Lipinski S, Wild B, Camargo SM, Singer D, Richter A, Kuba K, ... ... Clevers H, et al. ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature. 487: 477-81. PMID 22837003 DOI: 10.1038/nature11228  1
2012 Gloerich M, ten Klooster JP, Vliem MJ, Koorman T, Zwartkruis FJ, Clevers H, Bos JL. Rap2A links intestinal cell polarity to brush border formation. Nature Cell Biology. 14: 793-801. PMID 22797597 DOI: 10.1038/ncb2537  1
2012 de Lau W, Kujala P, Schneeberger K, Middendorp S, Li VS, Barker N, Martens A, Hofhuis F, DeKoter RP, Peters PJ, Nieuwenhuis E, Clevers H. Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts". Molecular and Cellular Biology. 32: 3639-47. PMID 22778137 DOI: 10.1128/MCB.00434-12  1
2012 Muñoz J, Stange DE, Schepers AG, van de Wetering M, Koo BK, Itzkovitz S, Volckmann R, Kung KS, Koster J, Radulescu S, Myant K, Versteeg R, Sansom OJ, van Es JH, Barker N, ... ... Clevers H, et al. The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers. The Embo Journal. 31: 3079-91. PMID 22692129 DOI: 10.1038/emboj.2012.166  1
2012 Li VS, Ng SS, Boersema PJ, Low TY, Karthaus WR, Gerlach JP, Mohammed S, Heck AJ, Maurice MM, Mahmoudi T, Clevers H. Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex. Cell. 149: 1245-56. PMID 22682247 DOI: 10.1016/j.cell.2012.05.002  1
2012 Clevers H, Nusse R. Wnt/β-catenin signaling and disease. Cell. 149: 1192-205. PMID 22682243 DOI: 10.1016/j.cell.2012.05.012  1
2012 de Lau WB, Snel B, Clevers HC. The R-spondin protein family. Genome Biology. 13: 242. PMID 22439850 DOI: 10.1186/gb-2012-13-3-242  1
2012 Yui S, Nakamura T, Sato T, Nemoto Y, Mizutani T, Zheng X, Ichinose S, Nagaishi T, Okamoto R, Tsuchiya K, Clevers H, Watanabe M. Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell. Nature Medicine. 18: 618-23. PMID 22406745 DOI: 10.1038/nm.2695  1
2012 Lander AD, Kimble J, Clevers H, Fuchs E, Montarras D, Buckingham M, Calof AL, Trumpp A, Oskarsson T. What does the concept of the stem cell niche really mean today? Bmc Biology. 10: 19. PMID 22405133 DOI: 10.1186/1741-7007-10-19  1
2012 van Es JH, Haegebarth A, Kujala P, Itzkovitz S, Koo BK, Boj SF, Korving J, van den Born M, van Oudenaarden A, Robine S, Clevers H. A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal. Molecular and Cellular Biology. 32: 1918-27. PMID 22393260 DOI: 10.1128/MCB.06288-11  1
2012 Wong VW, Stange DE, Page ME, Buczacki S, Wabik A, Itami S, van de Wetering M, Poulsom R, Wright NA, Trotter MW, Watt FM, Winton DJ, Clevers H, Jensen KB. Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling. Nature Cell Biology. 14: 401-8. PMID 22388892 DOI: 10.1038/ncb2464  1
2012 Itzkovitz S, Blat IC, Jacks T, Clevers H, van Oudenaarden A. Optimality in the development of intestinal crypts. Cell. 148: 608-19. PMID 22304925 DOI: 10.1016/j.cell.2011.12.025  1
2012 Stringer EJ, Duluc I, Saandi T, Davidson I, Bialecka M, Sato T, Barker N, Clevers H, Pritchard CA, Winton DJ, Wright NA, Freund JN, Deschamps J, Beck F. Cdx2 determines the fate of postnatal intestinal endoderm. Development (Cambridge, England). 139: 465-74. PMID 22190642 DOI: 10.1242/dev.070722  1
2012 Nieuwenhuis MH, Douma KF, Bleiker EM, Aaronson NK, Clevers H, Vasen HF. Clinical evidence for an association between familial adenomatous polyposis and type II diabetes. International Journal of Cancer. Journal International Du Cancer. 131: 1488-9. PMID 22120196 DOI: 10.1002/ijc.27370  1
2012 Itzkovitz S, Lyubimova A, Blat IC, Maynard M, van Es J, Lees J, Jacks T, Clevers H, van Oudenaarden A. Single-molecule transcript counting of stem-cell markers in the mouse intestine. Nature Cell Biology. 14: 106-14. PMID 22119784 DOI: 10.1038/ncb2384  1
2011 Dalerba P, Kalisky T, Sahoo D, Rajendran PS, Rothenberg ME, Leyrat AA, Sim S, Okamoto J, Johnston DM, Qian D, Zabala M, Bueno J, Neff NF, Wang J, Shelton AA, ... ... Clevers H, et al. Single-cell dissection of transcriptional heterogeneity in human colon tumors. Nature Biotechnology. 29: 1120-7. PMID 22081019 DOI: 10.1038/nbt.2038  1
2011 Jung P, Sato T, Merlos-Suárez A, Barriga FM, Iglesias M, Rossell D, Auer H, Gallardo M, Blasco MA, Sancho E, Clevers H, Batlle E. Isolation and in vitro expansion of human colonic stem cells. Nature Medicine. 17: 1225-7. PMID 21892181 DOI: 10.1038/nm.2470  1
2011 Sato T, Stange DE, Ferrante M, Vries RG, Van Es JH, Van den Brink S, Van Houdt WJ, Pronk A, Van Gorp J, Siersema PD, Clevers H. Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium. Gastroenterology. 141: 1762-72. PMID 21889923 DOI: 10.1053/j.gastro.2011.07.050  1
2011 Sylva M, Li VS, Buffing AA, van Es JH, van den Born M, van der Velden S, Gunst Q, Koolstra JH, Moorman AF, Clevers H, van den Hoff MJ. The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis. Plos One. 6: e22616. PMID 21826198 DOI: 10.1371/journal.pone.0022616  1
2011 Simons BD, Clevers H. Stem cell self-renewal in intestinal crypt. Experimental Cell Research. 317: 2719-24. PMID 21787769 DOI: 10.1016/j.yexcr.2011.07.010  1
2011 de Lau W, Barker N, Low TY, Koo BK, Li VS, Teunissen H, Kujala P, Haegebarth A, Peters PJ, van de Wetering M, Stange DE, van Es JE, Guardavaccaro D, Schasfoort RB, Mohri Y, ... ... Clevers H, et al. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature. 476: 293-7. PMID 21727895 DOI: 10.1038/nature10337  1
2011 Froeling FE, Feig C, Chelala C, Dobson R, Mein CE, Tuveson DA, Clevers H, Hart IR, Kocher HM. Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-β-catenin signaling to slow tumor progression. Gastroenterology. 141: 1486-97, 1497.e1-14. PMID 21704588 DOI: 10.1053/j.gastro.2011.06.047  1
2011 Di Palma S, Stange D, van de Wetering M, Clevers H, Heck AJ, Mohammed S. Highly sensitive proteome analysis of FACS-sorted adult colon stem cells. Journal of Proteome Research. 10: 3814-9. PMID 21696214 DOI: 10.1021/pr200367p  1
2011 Simons BD, Clevers H. Strategies for homeostatic stem cell self-renewal in adult tissues. Cell. 145: 851-62. PMID 21663791 DOI: 10.1016/j.cell.2011.05.033  1
2011 Merlos-Suárez A, Barriga FM, Jung P, Iglesias M, Céspedes MV, Rossell D, Sevillano M, Hernando-Momblona X, da Silva-Diz V, Muñoz P, Clevers H, Sancho E, Mangues R, Batlle E. The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. Cell Stem Cell. 8: 511-24. PMID 21419747 DOI: 10.1016/j.stem.2011.02.020  1
2011 Gerbe F, van Es JH, Makrini L, Brulin B, Mellitzer G, Robine S, Romagnolo B, Shroyer NF, Bourgaux JF, Pignodel C, Clevers H, Jay P. Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium. The Journal of Cell Biology. 192: 767-80. PMID 21383077 DOI: 10.1083/jcb.201010127  1
2011 Schepers AG, Vries R, van den Born M, van de Wetering M, Clevers H. Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes. The Embo Journal. 30: 1104-9. PMID 21297579 DOI: 10.1038/emboj.2011.26  1
2011 Sato T, van Es JH, Snippert HJ, Stange DE, Vries RG, van den Born M, Barker N, Shroyer NF, van de Wetering M, Clevers H. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature. 469: 415-8. PMID 21113151 DOI: 10.1038/nature09637  1
2011 Demarque MD, Nacerddine K, Neyret-Kahn H, Andrieux A, Danenberg E, Jouvion G, Bomme P, Hamard G, Romagnolo B, Terris B, Cumano A, Barker N, Clevers H, Dejean A. Sumoylation by Ubc9 regulates the stem cell compartment and structure and function of the intestinal epithelium in mice. Gastroenterology. 140: 286-96. PMID 20951138 DOI: 10.1053/j.gastro.2010.10.002  1
2010 Mokry M, Hatzis P, de Bruijn E, Koster J, Versteeg R, Schuijers J, van de Wetering M, Guryev V, Clevers H, Cuppen E. Efficient double fragmentation ChiP-seq provides nucleotide resolution protein-DNA binding profiles Plos One. 5. PMID 21152096 DOI: 10.1371/journal.pone.0015092  1
2010 Mahmoudi T, Boj SF, Hatzis P, Li VS, Taouatas N, Vries RG, Teunissen H, Begthel H, Korving J, Mohammed S, Heck AJ, Clevers H. The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis. Plos Biology. 8: e1000539. PMID 21103407 DOI: 10.1371/journal.pbio.1000539  1
2010 Qiu W, Wang X, Leibowitz B, Liu H, Barker N, Okada H, Oue N, Yasui W, Clevers H, Schoen RE, Yu J, Zhang L. Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 107: 20027-32. PMID 21041628 DOI: 10.1073/pnas.1010430107  1
2010 Cole AM, Ridgway RA, Derkits SE, Parry L, Barker N, Clevers H, Clarke AR, Sansom OJ. P21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium Embo Molecular Medicine. 2: 472-486. PMID 20976827 DOI: 10.1002/emmm.201000101  1
2010 van Es JH, de Geest N, van de Born M, Clevers H, Hassan BA. Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors. Nature Communications. 1: 18. PMID 20975679 DOI: 10.1038/ncomms1017  1
2010 Snippert HJ, van der Flier LG, Sato T, van Es JH, van den Born M, Kroon-Veenboer C, Barker N, Klein AM, van Rheenen J, Simons BD, Clevers H. Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. Cell. 143: 134-44. PMID 20887898 DOI: 10.1016/j.cell.2010.09.016  1
2010 Cole AM, Myant K, Reed KR, Ridgway RA, Athineos D, Van den Brink GR, Muncan V, Clevers H, Clarke AR, Sicinski P, Sansom OJ. Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss. Cancer Research. 70: 8149-58. PMID 20736363 DOI: 10.1158/0008-5472.CAN-10-0315  1
2010 Ashton GH, Morton JP, Myant K, Phesse TJ, Ridgway RA, Marsh V, Wilkins JA, Athineos D, Muncan V, Kemp R, Neufeld K, Clevers H, Brunton V, Winton DJ, Wang X, et al. Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Developmental Cell. 19: 259-69. PMID 20708588 DOI: 10.1016/j.devcel.2010.07.015  1
2010 Verzi MP, Hatzis P, Sulahian R, Philips J, Schuijers J, Shin H, Freed E, Lynch JP, Dang DT, Brown M, Clevers H, Liu XS, Shivdasani RA. TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions. Proceedings of the National Academy of Sciences of the United States of America. 107: 15157-62. PMID 20696899 DOI: 10.1073/pnas.1003822107  1
2010 Verheyen EM, Clevers H. Wnts as self-renewal factors: mammary stem cells and beyond. Cell Stem Cell. 6: 494-5. PMID 20569681 DOI: 10.1016/j.stem.2010.05.004  1
2010 Kosinski C, Stange DE, Xu C, Chan AS, Ho C, Yuen ST, Mifflin RC, Powell DW, Clevers H, Leung SY, Chen X. Indian hedgehog regulates intestinal stem cell fate through epithelial-mesenchymal interactions during development. Gastroenterology. 139: 893-903. PMID 20542037 DOI: 10.1053/j.gastro.2010.06.014  1
2010 Snippert HJ, Haegebarth A, Kasper M, Jaks V, van Es JH, Barker N, van de Wetering M, van den Born M, Begthel H, Vries RG, Stange DE, Toftgård R, Clevers H. Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science (New York, N.Y.). 327: 1385-9. PMID 20223988 DOI: 10.1126/science.1184733  1
2010 Quyn AJ, Appleton PL, Carey FA, Steele RJ, Barker N, Clevers H, Ridgway RA, Sansom OJ, Näthke IS. Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue. Cell Stem Cell. 6: 175-81. PMID 20144789 DOI: 10.1016/j.stem.2009.12.007  1
2010 Sue Ng S, Mahmoudi T, Li VS, Hatzis P, Boersema PJ, Mohammed S, Heck AJ, Clevers H. MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway. Biological Chemistry. 391: 171-80. PMID 20128690 DOI: 10.1515/BC.2010.028  1
2010 Barker N, Huch M, Kujala P, van de Wetering M, Snippert HJ, van Es JH, Sato T, Stange DE, Begthel H, van den Born M, Danenberg E, van den Brink S, Korving J, Abo A, Peters PJ, ... ... Clevers H, et al. Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Cell Stem Cell. 6: 25-36. PMID 20085740 DOI: 10.1016/j.stem.2009.11.013  1
2010 Menke V, van Es JH, de Lau W, van den Born M, Kuipers EJ, Siersema PD, de Bruin RW, Kusters JG, Clevers H. Conversion of metaplastic Barrett's epithelium into post-mitotic goblet cells by gamma-secretase inhibition. Disease Models & Mechanisms. 3: 104-10. PMID 20075383 DOI: 10.1242/dmm.003012  1
2010 Hollestelle A, Nagel JH, Smid M, Lam S, Elstrodt F, Wasielewski M, Ng SS, French PJ, Peeters JK, Rozendaal MJ, Riaz M, Koopman DG, Ten Hagen TL, de Leeuw BH, Zwarthoff EC, ... ... Clevers H, et al. Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines. Breast Cancer Research and Treatment. 121: 53-64. PMID 19593635 DOI: 10.1007/s10549-009-0460-8  1
2009 Faro A, Boj SF, Clevers H. Fishing for intestinal cancer models: unraveling gastrointestinal homeostasis and tumorigenesis in zebrafish. Zebrafish. 6: 361-76. PMID 19929219 DOI: 10.1089/zeb.2009.0617  1
2009 Mahmoudi T, Li VS, Ng SS, Taouatas N, Vries RG, Mohammed S, Heck AJ, Clevers H. The kinase TNIK is an essential activator of Wnt target genes. The Embo Journal. 28: 3329-40. PMID 19816403 DOI: 10.1038/emboj.2009.285  1
2009 Fu H, Cai J, Clevers H, Fast E, Gray S, Greenberg R, Jain MK, Ma Q, Qiu M, Rowitch DH, Taylor CM, Stiles CD. A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 11399-408. PMID 19741146 DOI: 10.1523/JNEUROSCI.0160-09.2009  1
2009 Jansen M, Ten Klooster JP, Offerhaus GJ, Clevers H. LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism. Physiological Reviews. 89: 777-98. PMID 19584313 DOI: 10.1152/physrev.00026.2008  1
2009 Gregorieff A, Stange DE, Kujala P, Begthel H, van den Born M, Korving J, Peters PJ, Clevers H. The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium. Gastroenterology. 137: 1333-45.e1-3. PMID 19549527 DOI: 10.1053/j.gastro.2009.06.044  1
2009 Ye F, Chen Y, Hoang T, Montgomery RL, Zhao XH, Bu H, Hu T, Taketo MM, Van Es JH, Clevers H, Hsieh J, Bassel-Duby R, Olson EN, Lu QR. HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the Β-catenin-TCF interaction Nature Neuroscience. 12: 829-838. PMID 19503085 DOI: 10.1038/nn.2333  1
2009 ten Klooster JP, Jansen M, Yuan J, Oorschot V, Begthel H, Di Giacomo V, Colland F, de Koning J, Maurice MM, Hornbeck P, Clevers H. Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex. Developmental Cell. 16: 551-62. PMID 19386264 DOI: 10.1016/j.devcel.2009.01.016  1
2009 Faro A, Boj SF, Ambrósio R, van den Broek O, Korving J, Clevers H. T-cell factor 4 (tcf7l2) is the main effector of Wnt signaling during zebrafish intestine organogenesis. Zebrafish. 6: 59-68. PMID 19374549 DOI: 10.1089/zeb.2009.0580  1
2009 Snippert HJ, van Es JH, van den Born M, Begthel H, Stange DE, Barker N, Clevers H. Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine. Gastroenterology. 136: 2187-2194.e1. PMID 19324043 DOI: 10.1053/j.gastro.2009.03.002  1
2009 van der Flier LG, van Gijn ME, Hatzis P, Kujala P, Haegebarth A, Stange DE, Begthel H, van den Born M, Guryev V, Oving I, van Es JH, Barker N, Peters PJ, van de Wetering M, Clevers H. Transcription factor achaete scute-like 2 controls intestinal stem cell fate. Cell. 136: 903-12. PMID 19269367 DOI: 10.1016/j.cell.2009.01.031  1
2009 Barker N, Ridgway RA, van Es JH, van de Wetering M, Begthel H, van den Born M, Danenberg E, Clarke AR, Sansom OJ, Clevers H. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature. 457: 608-11. PMID 19092804 DOI: 10.1038/nature07602  1
2009 van Stralen E, van de Wetering M, Agnelli L, Neri A, Clevers HC, Bast BJ. Identification of primary MAFB target genes in multiple myeloma. Experimental Hematology. 37: 78-86. PMID 19013005 DOI: 10.1016/j.exphem.2008.08.006  1
2008 Goessling W, North TE, Lord AM, Ceol C, Lee S, Weidinger G, Bourque C, Strijbosch R, Haramis AP, Puder M, Clevers H, Moon RT, Zon LI. APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. Developmental Biology. 320: 161-74. PMID 18585699 DOI: 10.1016/j.ydbio.2008.05.526  1
2008 Burns CJ, Zhang J, Brown EC, Van Bibber AM, Van Es J, Clevers H, Ishikawa TO, Taketo MM, Vetter ML, Fuhrmann S. Investigation of Frizzled-5 during embryonic neural development in mouse. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 237: 1614-26. PMID 18489003 DOI: 10.1002/dvdy.21565  1
2008 Riccio O, van Gijn ME, Bezdek AC, Pellegrinet L, van Es JH, Zimber-Strobl U, Strobl LJ, Honjo T, Clevers H, Radtke F. Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2 Embo Reports. 9: 377-383. PMID 18274550 DOI: 10.1038/embor.2008.7  1
2007 Sabates-Bellver J, Van der Flier LG, de Palo M, Cattaneo E, Maake C, Rehrauer H, Laczko E, Kurowski MA, Bujnicki JM, Menigatti M, Luz J, Ranalli TV, Gomes V, Pastorelli A, Faggiani R, ... ... Clevers H, et al. Transcriptome profile of human colorectal adenomas. Molecular Cancer Research : McR. 5: 1263-75. PMID 18171984 DOI: 10.1158/1541-7786.MCR-07-0267  1
2007 Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, Haegebarth A, Korving J, Begthel H, Peters PJ, Clevers H. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature. 449: 1003-7. PMID 17934449 DOI: 10.1038/nature06196  1
2007 Kessler BM, Fortunati E, Melis M, Pals CE, Clevers H, Maurice MM. Proteome changes induced by knock-down of the deubiquitylating enzyme HAUSP/USP7. Journal of Proteome Research. 6: 4163-72. PMID 17927229 DOI: 10.1021/pr0702161  1
2007 van Noort M, Weerkamp F, Clevers HC, Staal FJ. Wnt signaling and phosphorylation status of beta-catenin: importance of the correct antibody tools. Blood. 110: 2778-9. PMID 17881649 DOI: 10.1182/blood-2007-05-092445  1
2007 De Leng WWJ, Jansen M, Keller JJ, De Gijsel M, Milne ANA, Morsink FHM, Weterman MAJ, Iacobuzio-Donahue CA, Clevers HC, Giardiello FM, Offerhaus GJA. Peutz-Jeghers syndrome polyps are polyclonal with expanded progenitor cell compartment [5] Gut. 56: 1475-1476. PMID 17872577 DOI: 10.1136/gut.2007.128132  1
2007 Muncan V, Faro A, Haramis AP, Hurlstone AF, Wienholds E, van Es J, Korving J, Begthel H, Zivkovic D, Clevers H. T-cell factor 4 (Tcf7l2) maintains proliferative compartments in zebrafish intestine. Embo Reports. 8: 966-73. PMID 17823612 DOI: 10.1038/sj.embor.7401071  1
2007 Wehkamp J, Wang G, Kübler I, Nuding S, Gregorieff A, Schnabel A, Kays RJ, Fellermann K, Burk O, Schwab M, Clevers H, Bevins CL, Stange EF. The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4. Journal of Immunology (Baltimore, Md. : 1950). 179: 3109-18. PMID 17709525 DOI: 10.4049/jimmunol.179.5.3109  1
2007 Brugmann SA, Goodnough LH, Gregorieff A, Leucht P, ten Berge D, Fuerer C, Clevers H, Nusse R, Helms JA. Wnt signaling mediates regional specification in the vertebrate face. Development (Cambridge, England). 134: 3283-95. PMID 17699607 DOI: 10.1242/dev.005132  1
2007 Mori-Akiyama Y, van den Born M, van Es JH, Hamilton SR, Adams HP, Zhang J, Clevers H, de Crombrugghe B. SOX9 is required for the differentiation of paneth cells in the intestinal epithelium. Gastroenterology. 133: 539-46. PMID 17681175 DOI: 10.1053/j.gastro.2007.05.020  1
2007 Sansom OJ, Meniel VS, Muncan V, Phesse TJ, Wilkins JA, Reed KR, Vass JK, Athineos D, Clevers H, Clarke AR. Myc deletion rescues Apc deficiency in the small intestine Nature. 446: 676-679. PMID 17377531 DOI: 10.1038/nature05674  1
2007 Vooijs M, Ong CT, Hadland B, Huppert S, Liu Z, Korving J, van den Born M, Stappenbeck T, Wu Y, Clevers H, Kopan R. Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE. Development (Cambridge, England). 134: 535-44. PMID 17215306 DOI: 10.1242/dev.02733  1
2006 Muncan V, Sansom OJ, Tertoolen L, Phesse TJ, Begthel H, Sancho E, Cole AM, Gregorieff A, Moreno De Alboran I, Clevers H, Clarke AR. Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc Molecular and Cellular Biology. 26: 8418-8426. PMID 16954380 DOI: 10.1128/MCB.00821-06  1
2006 Markiewicz E, Tilgner K, Barker N, van de Wetering M, Clevers H, Dorobek M, Hausmanowa-Petrusewicz I, Ramaekers FC, Broers JL, Blankesteijn WM, Salpingidou G, Wilson RG, Ellis JA, Hutchison CJ. The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus. The Embo Journal. 25: 3275-85. PMID 16858403 DOI: 10.1038/sj.emboj.7601230  1
2006 Haramis AP, Hurlstone A, van der Velden Y, Begthel H, van den Born M, Offerhaus GJ, Clevers HC. Adenomatous polyposis coli-deficient zebrafish are susceptible to digestive tract neoplasia. Embo Reports. 7: 444-9. PMID 16439994 DOI: 10.1038/sj.embor.7400638  1
2005 Batlle E, Bacani J, Begthel H, Jonkheer S, Jonkeer S, Gregorieff A, van de Born M, Malats N, Sancho E, Boon E, Pawson T, Gallinger S, Pals S, Clevers H. EphB receptor activity suppresses colorectal cancer progression. Nature. 435: 1126-30. PMID 15973414 DOI: 10.1038/nature03626  1
2005 van Es JH, van Gijn ME, Riccio O, van den Born M, Vooijs M, Begthel H, Cozijnsen M, Robine S, Winton DJ, Radtke F, Clevers H. Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature. 435: 959-63. PMID 15959515 DOI: 10.1038/nature03659  1
2005 Sansom OJ, Reed KR, Van De Wetering M, Muncan V, Winton DJ, Clevers H, Clarke AR. Cyclin D1 is not an immediate target of β-catenin following Apc loss in the intestine Journal of Biological Chemistry. 280: 28463-28467. PMID 15946945 DOI: 10.1074/jbc.M500191200  1
2005 Pinto D, Clevers H. Wnt control of stem cells and differentiation in the intestinal epithelium. Experimental Cell Research. 306: 357-63. PMID 15925592 DOI: 10.1016/j.yexcr.2005.02.022  1
2005 Glass DA, Bialek P, Ahn JD, Starbuck M, Patel MS, Clevers H, Taketo MM, Long F, McMahon AP, Lang RA, Karsenty G. Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Developmental Cell. 8: 751-64. PMID 15866165 DOI: 10.1016/j.devcel.2005.02.017  1
2005 van Es JH, Jay P, Gregorieff A, van Gijn ME, Jonkheer S, Hatzis P, Thiele A, van den Born M, Begthel H, Brabletz T, Taketo MM, Clevers H. Wnt signalling induces maturation of Paneth cells in intestinal crypts. Nature Cell Biology. 7: 381-6. PMID 15778706 DOI: 10.1038/ncb1240  1
2005 Riedl JA, Brandt DT, Batlle E, Price LS, Clevers H, Bos JL. Down-regulation of Rap1 activity is involved in ephrinB1-induced cell contraction. The Biochemical Journal. 389: 465-9. PMID 15725075 DOI: 10.1042/BJ20050048  1
2005 Pinto D, Clevers H. Wnt, stem cells and cancer in the intestine. Biology of the Cell / Under the Auspices of the European Cell Biology Organization. 97: 185-96. PMID 15715524 DOI: 10.1042/BC20040094  1
2005 Staal FJ, Clevers HC. WNT signalling and haematopoiesis: a WNT-WNT situation. Nature Reviews. Immunology. 5: 21-30. PMID 15630426 DOI: 10.1038/nri1529  1
2004 Boersma-Vreugdenhil GR, Kuipers J, Van Stralen E, Peeters T, Michaux L, Hagemeijer A, Pearson PL, Clevers HC, Bast BJ. The recurrent translocation t(14;20)(q32;q12) in multiple myeloma results in aberrant expression of MAFB: a molecular and genetic analysis of the chromosomal breakpoint. British Journal of Haematology. 126: 355-63. PMID 15257707 DOI: 10.1111/j.1365-2141.2004.05050.x  1
2004 Blache P, van de Wetering M, Duluc I, Domon C, Berta P, Freund JN, Clevers H, Jay P. SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes. The Journal of Cell Biology. 166: 37-47. PMID 15240568 DOI: 10.1083/jcb.200311021  1
2004 Derksen PW, Tjin E, Meijer HP, Klok MD, MacGillavry HD, van Oers MH, Lokhorst HM, Bloem AC, Clevers H, Nusse R, van der Neut R, Spaargaren M, Pals ST. Illegitimate WNT signaling promotes proliferation of multiple myeloma cells. Proceedings of the National Academy of Sciences of the United States of America. 101: 6122-7. PMID 15067127 DOI: 10.1073/pnas.0305855101  1
2004 Gregorieff A, Grosschedl R, Clevers H. Hindgut defects and transformation of the gastro-intestinal tract in Tcf4(-/-)/Tcf1(-/-) embryos. The Embo Journal. 23: 1825-33. PMID 15057272 DOI: 10.1038/sj.emboj.7600191  1
2004 Haramis AP, Begthel H, van den Born M, van Es J, Jonkheer S, Offerhaus GJ, Clevers H. De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine. Science (New York, N.Y.). 303: 1684-6. PMID 15017003 DOI: 10.1126/science.1093587  1
2004 Baas AF, Kuipers J, van der Wel NN, Batlle E, Koerten HK, Peters PJ, Clevers HC. Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. Cell. 116: 457-66. PMID 15016379  1
2004 Smit L, Baas A, Kuipers J, Korswagen H, van de Wetering M, Clevers H. Wnt activates the Tak1/Nemo-like kinase pathway. The Journal of Biological Chemistry. 279: 17232-40. PMID 14960582 DOI: 10.1074/jbc.M307801200  1
2003 Morkel M, Huelsken J, Wakamiya M, Ding J, van de Wetering M, Clevers H, Taketo MM, Behringer RR, Shen MM, Birchmeier W. Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation. Development (Cambridge, England). 130: 6283-94. PMID 14623818 DOI: 10.1242/dev.00859  1
2003 Hurlstone AF, Haramis AP, Wienholds E, Begthel H, Korving J, Van Eeden F, Cuppen E, Zivkovic D, Plasterk RH, Clevers H. The Wnt/beta-catenin pathway regulates cardiac valve formation. Nature. 425: 633-7. PMID 14534590 DOI: 10.1038/nature02028  1
2003 Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, Prescott AR, Clevers HC, Alessi DR. MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. The Embo Journal. 22: 5102-14. PMID 14517248 DOI: 10.1093/emboj/cdg490  1
2003 Brinkmeier ML, Potok MA, Cha KB, Gridley T, Stifani S, Meeldijk J, Clevers H, Camper SA. TCF and Groucho-related genes influence pituitary growth and development. Molecular Endocrinology (Baltimore, Md.). 17: 2152-61. PMID 12907761 DOI: 10.1210/me.2003-0225  1
2003 Pinto D, Gregorieff A, Begthel H, Clevers H. Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes & Development. 17: 1709-13. PMID 12865297 DOI: 10.1101/gad.267103  1
2003 Baas AF, Boudeau J, Sapkota GP, Smit L, Medema R, Morrice NA, Alessi DR, Clevers HC. Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD Embo Journal. 22: 3062-3072. PMID 12805220 DOI: 10.1093/emboj/cdg292  1
2003 Held W, Clevers H, Grosschedl R. Redundant functions of TCF-1 and LEF-1 during T and NK cell development, but unique role of TCF-1 for Ly49 NK cell receptor acquisition. European Journal of Immunology. 33: 1393-8. PMID 12731066 DOI: 10.1002/eji.200323840  1
2003 Bienz M, Clevers H. Armadillo/beta-catenin signals in the nucleus--proof beyond a reasonable doubt? Nature Cell Biology. 5: 179-82. PMID 12646868 DOI: 10.1038/ncb0303-179  1
2003 Staal FJ, Clevers HC. Wnt signaling in the thymus. Current Opinion in Immunology. 15: 204-8. PMID 12633671  1
2002 Oving IM, Clevers HC. Molecular causes of colon cancer. European Journal of Clinical Investigation. 32: 448-57. PMID 12059991  0.01
2002 Korswagen HC, Coudreuse DY, Betist MC, van de Water S, Zivkovic D, Clevers HC. The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans. Genes & Development. 16: 1291-302. PMID 12023307 DOI: 10.1101/gad.981802  1
2002 Cheon SS, Cheah AY, Turley S, Nadesan P, Poon R, Clevers H, Alman BA. beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds. Proceedings of the National Academy of Sciences of the United States of America. 99: 6973-8. PMID 11983872 DOI: 10.1073/pnas.102657399  1
2002 Lustig B, Jerchow B, Sachs M, Weiler S, Pietsch T, Karsten U, van de Wetering M, Clevers H, Schlag PM, Birchmeier W, Behrens J. Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Molecular and Cellular Biology. 22: 1184-93. PMID 11809809 DOI: 10.1128/MCB.22.4.1184-1193.2002  1
2002 Staal FJ, van Noort M, Strous GJ, Clevers HC. Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin. Embo Reports. 3: 63-8. PMID 11751573 DOI: 10.1093/embo-reports/kvf002  1
2001 Barker N, Hurlstone A, Musisi H, Miles A, Bienz M, Clevers H. The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation. The Embo Journal. 20: 4935-43. PMID 11532957 DOI: 10.1093/emboj/20.17.4935  1
2001 Meyaard L, van der Vuurst de Vries AR, de Ruiter T, Lanier LL, Phillips JH, Clevers H. The epithelial cellular adhesion molecule (Ep-CAM) is a ligand for the leukocyte-associated immunoglobulin-like receptor (LAIR). The Journal of Experimental Medicine. 194: 107-12. PMID 11435477 DOI: 10.1084/jem.194.1.107  1
2001 van Es JH, Giles RH, Clevers HC. The many faces of the tumor suppressor gene APC. Experimental Cell Research. 264: 126-34. PMID 11237529 DOI: 10.1006/excr.2000.5142  1
2000 Bienz M, Clevers H. Linking colorectal cancer to Wnt signaling. Cell. 103: 311-20. PMID 11057903  1
2000 Korswagen HC, Herman MA, Clevers HC. Distinct beta-catenins mediate adhesion and signalling functions in C. elegans. Nature. 406: 527-32. PMID 10952315 DOI: 10.1038/35020099  1
2000 Molenaar M, Brian E, Roose J, Clevers H, Destrée O. Differential expression of the Groucho-related genes 4 and 5 during early development of Xenopus laevis. Mechanisms of Development. 91: 311-5. PMID 10704855 DOI: 10.1016/S0925-4773(99)00259-2  1
2000 Barker N, Morin PJ, Clevers H. The Yin-Yang of TCF/β-catenin signaling Advances in Cancer Research. 77: 1-24. PMID 10549354 DOI: 10.1016/S0065-230X(08)60783-6  1
1999 Korswagen HC, Clevers HC. Activation and repression of wingless/Wnt target genes by the TCF/LEF-1 family of transcription factors. Cold Spring Harbor Symposia On Quantitative Biology. 64: 141-7. PMID 11232279  1
1999 van der Vuurst de Vries AR, Clevers H, Logtenberg T, Meyaard L. Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is differentially expressed during human B cell differentiation and inhibits B cell receptor-mediated signaling. European Journal of Immunology. 29: 3160-7. PMID 10540327 DOI: 10.1002/(SICI)1521-4141(199910)29:10<3160::AID-IMMU3160>3.0.CO;2-S  0.4
1999 Ishitani T, Ninomiya-Tsuji J, Nagai S, Nishita M, Meneghini M, Barker N, Waterman M, Bowerman B, Clevers H, Shibuya H, Matsumoto K. The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF. Nature. 399: 798-802. PMID 10391247 DOI: 10.1038/21674  1
1999 Staal FJ, Burgering BM, van de Wetering M, Clevers HC. Tcf-1-mediated transcription in T lymphocytes: differential role for glycogen synthase kinase-3 in fibroblasts and T cells. International Immunology. 11: 317-23. PMID 10221643  1
1999 Galceran J, Fariñas I, Depew MJ, Clevers H, Grosschedl R. Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice. Genes & Development. 13: 709-17. PMID 10090727 DOI: 10.1101/GAD.13.6.709  1
1999 Kuipers J, Vaandrager JW, Weghuis DO, Pearson PL, Scheres J, Lokhorst HM, Clevers H, Bast BJ. Fluorescence in situ hybridization analysis shows the frequent occurrence of 14q32.3 rearrangements with involvement of immunoglobulin switch regions in myeloma cell lines. Cancer Genetics and Cytogenetics. 109: 99-107. PMID 10087940 DOI: 10.1016/S0165-4608(98)00157-5  1
1999 van Es JH, Kirkpatrick C, van de Wetering M, Molenaar M, Miles A, Kuipers J, Destrée O, Peifer M, Clevers H. Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor. Current Biology : Cb. 9: 105-8. PMID 10021369 DOI: 10.1016/S0960-9822(99)80024-4  1
1998 Zhang Z, Hartmann H, Do VM, Abramowski D, Sturchler-Pierrat C, Staufenbiel M, Sommer B, van de Wetering M, Clevers H, Saftig P, De Strooper B, He X, Yankner BA. Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature. 395: 698-702. PMID 9790190 DOI: 10.1038/27208  1
1998 Cavallo RA, Cox RT, Moline MM, Roose J, Polevoy GA, Clevers H, Peifer M, Bejsovec A. Drosophila Tcf and Groucho interact to repress Wingless signalling activity. Nature. 395: 604-8. PMID 9783586 DOI: 10.1038/26982  1
1998 van Beest M, Mortin M, Clevers H. Drosophila RpS3a, a novel Minute gene situated between the segment polarity genescubitus interruptus and dTCF. Nucleic Acids Research. 26: 4471-5. PMID 9742251 DOI: 10.1093/nar/26.19.4471  1
1998 de Lau WB, Hurenkamp J, Berendes P, Touw IP, Clevers HC, van Dijk MA. The gene encoding the granulocyte colony-stimulating factor receptor is a target for deregulation in pre-B ALL by the t(1;19)-specific oncoprotein E2A-Pbx1. Oncogene. 17: 503-10. PMID 9696044 DOI: 10.1038/sj.onc.1201967  1
1998 Dooijes D, van Beest M, van de Wetering M, Boulanger G, Jones T, Clevers H, Mortin MA. Genomic organization of the segment polarity gene pan in Drosophila melanogaster. Molecular & General Genetics : Mgg. 258: 45-52. PMID 9613571 DOI: 10.1007/s004380050705  1
1998 Korinek V, Barker N, Willert K, Molenaar M, Roose J, Wagenaar G, Markman M, Lamers W, Destree O, Clevers H. Two members of the Tcf family implicated in Wnt/β-catenin signaling during embryogenesis in the mouse Molecular and Cellular Biology. 18: 1248-1256. PMID 9488439  1
1997 Korver W, Roose J, Heinen K, Weghuis DO, de Bruijn D, van Kessel AG, Clevers H. The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization. Genomics. 46: 435-42. PMID 9441747 DOI: 10.1006/geno.1997.5065  1
1997 Schilham MW, Moerer P, Cumano A, Clevers HC. Sox-4 facilitates thymocyte differentiation. European Journal of Immunology. 27: 1292-5. PMID 9174623 DOI: 10.1002/eji.1830270534  1
1997 van de Wetering M, Cavallo R, Dooijes D, van Beest M, van Es J, Loureiro J, Ypma A, Hursh D, Jones T, Bejsovec A, Peifer M, Mortin M, Clevers H. Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF. Cell. 88: 789-99. PMID 9118222 DOI: 10.1016/S0092-8674(00)81925-X  1
1997 Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, Vogelstein B, Kinzler KW. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC Science. 275: 1787-1790. PMID 9065402 DOI: 10.1126/science.275.5307.1787  1
1997 Korinek V, Barker N, Morin PJ, Van Wichen D, De Weger R, Kinzler KW, Vogelstein B, Clevers H. Constitutive transcriptional activation by a β-catenin-Tcf complex in APC(-/-) colon carcinoma Science. 275: 1784-1787. PMID 9065401 DOI: 10.1126/science.275.5307.1784  1
1996 Petersen EJ, Rozenberg-Arska M, Dekker AW, Clevers HC, Verdonck LF. Allogeneic bone marrow transplantation can restore CD4+ T-lymphocyte count and immune function in idiopathic CD4+ T-lymphocytopenia. Bone Marrow Transplantation. 18: 813-5. PMID 8899203  1
1996 Clevers HC, Grosschedl R. Transcriptional control of lymphoid development: lessons from gene targeting. Immunology Today. 17: 336-43. PMID 8763820  0.04
1996 Hagens G, Galley Y, Glaser I, Davis WC, Baldwin CL, Clevers H, Dobbelaere DAE. Cloning, sequencing and expression of the bovine CD3ε and TCR-ζ chains, two invariant components of the T-cell receptor complex Gene. 169: 165-171. PMID 8647441 DOI: 10.1016/0378-1119(95)00769-5  1
1995 van Houte LP, Chuprina VP, van der Wetering M, Boelens R, Kaptein R, Clevers H. Solution structure of the sequence-specific HMG box of the lymphocyte transcriptional activator Sox-4. The Journal of Biological Chemistry. 270: 30516-24. PMID 8530483 DOI: 10.1074/jbc.270.51.30516  1
1994 Wijngaard PL, MacHugh ND, Metzelaar MJ, Romberg S, Bensaid A, Pepin L, Davis WC, Clevers HC. Members of the novel WC1 gene family are differentially expressed on subsets of bovine CD4-CD8- gamma delta T lymphocytes. Journal of Immunology (Baltimore, Md. : 1950). 152: 3476-82. PMID 7511649  1
1993 Schilham MW, van Eijk M, van de Wetering M, Clevers HC. The murine Sox-4 protein is encoded on a single exon. Nucleic Acids Research. 21: 2009. PMID 8493110  1
1993 Schuurman HJ, Hu HZ, de Weger RA, Clevers HC. Thoughts on the thymus and the T-lymphocyte repertoire. Relevance to the tolerance of the immune response. The Netherlands Journal of Medicine. 43: 38-54. PMID 8232693  0.04
1993 Clevers HC, Oosterwegel MA, Georgopoulos K. Transcription factors in early T-cell development. Immunology Today. 14: 591-6. PMID 7905739 DOI: 10.1016/0167-5699(93)90198-T  1
1992 Gastrop J, Hoevenagel R, Young JR, Clevers HC. A common ancestor of the mammalian transcription factors TCF-1 and TCF-1 alpha/LEF-1 expressed in chicken T cells. European Journal of Immunology. 22: 1327-30. PMID 1577072 DOI: 10.1002/eji.1830220531  0.01
1992 Metzelaar MJ, Clevers HC. Lysosomal membrane glycoproteins in platelets. Thrombosis and Haemostasis. 68: 378-82. PMID 1448767  1
1992 Wijngaard PL, Metzelaar MJ, MacHugh ND, Morrison WI, Clevers HC. Molecular characterization of the WC1 antigen expressed specifically on bovine CD4-CD8- gamma delta T lymphocytes. Journal of Immunology (Baltimore, Md. : 1950). 149: 3273-7. PMID 1431105  1
1992 Demetrick DJ, Herlyn D, Tretiak M, Creasey D, Clevers H, Donoso LA, Vennegoor CJ, Dixon WT, Jerry LM. ME491 melanoma-associated glycoprotein family: antigenic identity of ME491, NKI/C-3, neuroglandular antigen (NGA), and CD63 proteins. Journal of the National Cancer Institute. 84: 422-9. PMID 1371549 DOI: 10.1093/JNCI/84.6.422  1
1992 Oosterwegel M, Timmerman J, Leiden J, Clevers H. Expression of GATA-3 during lymphocyte differentiation and mouse embryogenesis Developmental Immunology. 3: 1-11. PMID 1343100 DOI: 10.1155/1992/27903  1
1991 Bensaid A, Kaushal A, Baldwin CL, Clevers H, Young JR, Kemp SJ, MacHugh ND, Toye PG, Teale AJ. Identification of expressed bovine class I MHC genes at two loci and demonstration of physical linkage. Immunogenetics. 33: 247-54. PMID 2026460 DOI: 10.1007/BF00230502  1
1991 Metzelaar MJ, Wijngaard PL, Peters PJ, Sixma JJ, Nieuwenhuis HK, Clevers HC. CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells. The Journal of Biological Chemistry. 266: 3239-45. PMID 1993697  1
1991 Oosterwegel MA, van de Wetering ML, Holstege FC, Prosser HM, Owen MJ, Clevers HC. TCF-1, a T cell-specific transcription factor of the HMG box family, interacts with sequence motifs in the TCR beta and TCR delta enhancers. International Immunology. 3: 1189-92. PMID 1836958  1
1991 Oosterwegel M, van de Wetering M, Dooijes D, Klomp L, Winoto A, Georgopoulos K, Meijlink F, Clevers H. Cloning of murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and T cell receptor alpha enhancers. The Journal of Experimental Medicine. 173: 1133-42. PMID 1827138 DOI: 10.1084/JEM.173.5.1133  1
1991 Clevers HC, Owen MJ. Towards a molecular understanding of T-cell differentiation. Immunology Today. 12: 86-92. PMID 1676267 DOI: 10.1016/0167-5699(91)90163-N  1
1990 Dobbelaere DAE, Prospero TD, Roditi IJ, Kelke C, Baumann I, Eichhorn M, Williams RO, Ahmed JS, Baldwin CL, Clevers H, Morrison WI. Expression of Tac antigen component of bovine interleukin-2 receptor in different leukocyte populations infected with Theileria parva or Theileria annulata Infection and Immunity. 58: 3847-3855. PMID 1979317  1
1990 Clevers H, MacHugh ND, Bensaid A, Dunlap S, Baldwin CL, Kaushal A, Iams K, Howard CJ, Morrison WI. Identification of a bovine surface antigen uniquely expressed on CD4-CD8- T cell receptor gamma/delta+ T lymphocytes. European Journal of Immunology. 20: 809-17. PMID 1971793 DOI: 10.1002/eji.1830200415  1
1989 Peters PJ, Geuze HJ, Van der Donk HA, Slot JW, Griffith JM, Stam NJ, Clevers HC, Borst J. Molecules relevant for T cell-target cell interaction are present in cytolytic granules of human T lymphocytes. European Journal of Immunology. 19: 1469-75. PMID 2789142 DOI: 10.1002/eji.1830190819  1
1989 Clevers H, Lonberg N, Dunlap S, Lacy E, Terhorst C. An enhancer located in a CpG-island 3' to the TCR/CD3-epsilon gene confers T lymphocyte-specificity to its promoter. The Embo Journal. 8: 2527-35. PMID 2583122  1
1988 Clevers H, Alarcon B, Wileman T, Terhorst C. The T cell receptor/CD3 complex: a dynamic protein ensemble. Annual Review of Immunology. 6: 629-62. PMID 3289580 DOI: 10.1146/annurev.iy.06.040188.003213  1
1988 Clevers HC, Dunlap S, Wileman TE, Terhorst C. Human CD3-epsilon gene contains three miniexons and is transcribed from a non-TATA promoter. Proceedings of the National Academy of Sciences of the United States of America. 85: 8156-60. PMID 3267235  1
1988 Clevers H, Dunlap S, Saito H, Georgopoulos K, Wileman T, Terhorst C. Characterization and expression of the murine CD3-epsilon gene. Proceedings of the National Academy of Sciences of the United States of America. 85: 8623-7. PMID 2973066  1
1988 Clevers H, Dunlap S, Terhorst C. The transmembrane orientation of the epsilon chain of the TcR/CD3 complex. European Journal of Immunology. 18: 705-10. PMID 2967760 DOI: 10.1002/eji.1830180508  1
1987 Gold DP, Clevers H, Alarcon B, Dunlap S, Novotny J, Williams AF, Terhorst C. Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family. Proceedings of the National Academy of Sciences of the United States of America. 84: 7649-53. PMID 3478717  1
1987 Saito H, Koyama T, Georgopoulos K, Clevers H, Haser WG, LeBien T, Tonegawa S, Terhorst C. Close linkage of the mouse and human CD3 gamma- and delta-chain genes suggests that their transcription is controlled by common regulatory elements. Proceedings of the National Academy of Sciences of the United States of America. 84: 9131-4. PMID 2827170  1
1986 Bloem AC, Clevers JC, Bast EJ, Ballieux RE. T cells in B cell chronic lymphocytic leukaemia. I. Decreased frequency of T lymphocytes secreting suppressor factor. Clinical and Experimental Immunology. 63: 188-93. PMID 3485483  0.48
1986 Clevers HC, de Bresser A, Kleinveld H, Gmelig-Meyling FH, Ballieux RE. Wheat germ agglutinin activates human T lymphocytes by stimulation of phosphoinositide hydrolysis. Journal of Immunology (Baltimore, Md. : 1950). 136: 3180-3. PMID 3007612  1
1985 Clevers HC, Hoeksema M, Gmelig-Meyling FH, Ballieux RE. Calcium ionophore A23187 induces interleukin 2 reactivity in human T cells. Scandinavian Journal of Immunology. 22: 633-8. PMID 3937226  1
1985 Clevers HC, Versteegen JM, Logtenberg T, Gmelig-Meyling FH, Ballieux RE. Synergistic action of A23187 and phorbol ester on human B cell activation. Journal of Immunology (Baltimore, Md. : 1950). 135: 3827-30. PMID 3934268  1
1985 Clevers HC, Bloem AC, Gmelig-Meyling F, Ballieux RE. Ligands of surface Ig raise cytoplasmic free Ca++ in human B cells. Scandinavian Journal of Immunology. 22: 557-62. PMID 3878580  1
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