Hans (Johannes Carolus) Clevers - Publications

Affiliations: 
1991- Utrecht University, Utrecht, Netherlands 
Area:
Molecular genetics, Molecular immunology
Website:
http://knaw.nl/nl/leden/leden/3984

134 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Mullenders J, de Jongh E, Brousali A, Roosen M, Blom JPA, Begthel H, Korving J, Jonges T, Kranenburg O, Meijer R, Clevers HC. Mouse and human urothelial cancer organoids: A tool for bladder cancer research. Proceedings of the National Academy of Sciences of the United States of America. PMID 30787188 DOI: 10.1073/pnas.1803595116  1
2019 Berkers G, van Mourik P, Vonk AM, Kruisselbrink E, Dekkers JF, de Winter-de Groot KM, Arets HGM, Marck-van der Wilt REP, Dijkema JS, Vanderschuren MM, Houwen RHJ, Heijerman HGM, van de Graaf EA, Elias SG, Majoor CJ, ... ... Clevers HC, et al. Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis. Cell Reports. 26: 1701-1708.e3. PMID 30759382 DOI: 10.1016/j.celrep.2019.01.068  1
2017 Noguchi S, Arakawa T, Fukuda S, Furuno M, Hasegawa A, Hori F, Ishikawa-Kato S, Kaida K, Kaiho A, Kanamori-Katayama M, Kawashima T, Kojima M, Kubosaki A, Manabe RI, Murata M, ... ... Clevers HC, et al. FANTOM5 CAGE profiles of human and mouse samples. Scientific Data. 4: 170112. PMID 28850106 DOI: 10.1038/sdata.2017.112  1
2017 Dutta D, Clevers H. Organoid culture systems to study host-pathogen interactions. Current Opinion in Immunology. 48: 15-22. PMID 28756233 DOI: 10.1016/j.coi.2017.07.012  1
2017 Joosten SPJ, Zeilstra J, van Andel H, Mijnals RC, Zaunbrecher J, Duivenvoorden AAM, van de Wetering M, Clevers H, Spaargaren M, Pals ST. MET Signaling Mediates Intestinal Crypt-Villus Development, Regeneration, and Adenoma Formation and Is Promoted by Stem Cell CD44 Isoforms. Gastroenterology. PMID 28716720 DOI: 10.1053/j.gastro.2017.07.008  1
2017 Naxerova K, Reiter JG, Brachtel E, Lennerz JK, van de Wetering M, Rowan A, Cai T, Clevers H, Swanton C, Nowak MA, Elledge SJ, Jain RK. Origins of lymphatic and distant metastases in human colorectal cancer. Science (New York, N.Y.). 357: 55-60. PMID 28684519 DOI: 10.1126/science.aai8515  1
2017 Beumer J, Clevers H. How the Gut Feels, Smells, and Talks. Cell. 170: 10-11. PMID 28666112 DOI: 10.1016/j.cell.2017.06.023  1
2017 Andersson-Rolf A, Zilbauer M, Koo BK, Clevers H. Stem Cells in Repair of Gastrointestinal Epithelia. Physiology (Bethesda, Md.). 32: 278-289. PMID 28615312 DOI: 10.1152/physiol.00005.2017  1
2017 Kretzschmar K, Clevers H. Wnt/β-catenin signaling in adult mammalian epithelial stem cells. Developmental Biology. 428: 273-282. PMID 28526587 DOI: 10.1016/j.ydbio.2017.05.015  1
2017 Mizutani T, Tsukamoto Y, Clevers H. Oncogene-inducible organoids as a miniature platform to assess cancer characteristics. The Journal of Cell Biology. 216: 1505-1507. PMID 28512141 DOI: 10.1083/jcb.201704014  1
2017 Morcos MNF, Schoedel KB, Hoppe A, Behrendt R, Basak O, Clevers HC, Roers A, Gerbaulet A. SCA-1 Expression Level Identifies Quiescent Hematopoietic Stem and Progenitor Cells. Stem Cell Reports. 8: 1472-1478. PMID 28506535 DOI: 10.1016/j.stemcr.2017.04.012  1
2017 Bartfeld S, Clevers H. Stem cell-derived organoids and their application for medical research and patient treatment. Journal of Molecular Medicine (Berlin, Germany). 95: 729-738. PMID 28391362 DOI: 10.1007/s00109-017-1531-7  1
2017 Kruitwagen HS, Oosterhoff LA, Vernooij IG, Schrall IM, van Wolferen ME, Bannink F, Roesch C, van Uden L, Molenaar MR, Helms JB, Grinwis GC, Verstegen MM, van der Laan LJ, Huch M, Geijsen N, ... ... Clevers H, et al. Long-Term Adult Feline Liver Organoid Cultures for Disease Modeling of Hepatic Steatosis. Stem Cell Reports. PMID 28344000 DOI: 10.1016/j.stemcr.2017.02.015  1
2017 Dutta D, Heo I, Clevers H. Disease Modeling in Stem Cell-Derived 3D Organoid Systems. Trends in Molecular Medicine. PMID 28341301 DOI: 10.1016/j.molmed.2017.02.007  1
2017 Kretzschmar K, Clevers H. Everything has its time: Id2 clocks embryonic specification of Lgr5(+) gut stem cells. The Embo Journal. 36: 837-839. PMID 28298434 DOI: 10.15252/embj.201796482  1
2017 Sachs N, Tsukamoto Y, Kujala P, Peters PJ, Clevers H. Intestinal epithelial organoids fuse to form self-organizing tubes in floating collagen gels. Development (Cambridge, England). 144: 1107-1112. PMID 28292848 DOI: 10.1242/dev.143933  1
2017 Drost J, Clevers H. Translational applications of adult stem cell-derived organoids. Development (Cambridge, England). 144: 968-975. PMID 28292843 DOI: 10.1242/dev.140566  1
2017 Boj SF, Vonk AM, Statia M, Su J, Vries RR, Beekman JM, Clevers H. Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients. Journal of Visualized Experiments : Jove. PMID 28287550 DOI: 10.3791/55159  1
2017 Fumagalli A, Drost J, Suijkerbuijk SJ, van Boxtel R, de Ligt J, Offerhaus GJ, Begthel H, Beerling E, Tan EH, Sansom OJ, Cuppen E, Clevers H, van Rheenen J. Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids. Proceedings of the National Academy of Sciences of the United States of America. PMID 28270604 DOI: 10.1073/pnas.1701219114  1
2017 Tüysüz N, van Bloois L, van den Brink S, Begthel H, Verstegen MM, Cruz LJ, Hui L, van der Laan LJ, de Jonge J, Vries R, Braakman E, Mastrobattista E, Cornelissen JJ, Clevers H, Ten Berge D. Lipid-mediated Wnt protein stabilization enables serum-free culture of human organ stem cells. Nature Communications. 8: 14578. PMID 28262686 DOI: 10.1038/ncomms14578  1
2017 Driehuis E, Clevers H. WNT signaling events near the cell membrane and their pharmacological targeting for the treatment of cancer. British Journal of Pharmacology. PMID 28244067 DOI: 10.1111/bph.13758  1
2017 Öhlund D, Handly-Santana A, Biffi G, Elyada E, Almeida AS, Ponz-Sarvise M, Corbo V, Oni TE, Hearn SA, Lee EJ, Chio II, Hwang CI, Tiriac H, Baker LA, Engle DD, ... ... Clevers H, et al. Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer. The Journal of Experimental Medicine. PMID 28232471 DOI: 10.1084/jem.20162024  1
2017 Schneeberger K, Spee B, Costa P, Sachs N, Clevers H, Malda J. Converging biofabrication and organoid technologies: the next frontier in hepatic and intestinal tissue engineering? Biofabrication. PMID 28211365 DOI: 10.1088/1758-5090/aa6121  1
2017 Mahmoudi T, Boj SF, Hatzis P, Li VS, Taouatas N, Vries RG, Teunissen H, Begthel H, Korving J, Mohammed S, Heck AJ, Clevers H. Correction: The Leukemia-Associated Mllt10/Af10-Dot1l Are Tcf4/β-Catenin Coactivators Essential for Intestinal Homeostasis. Plos Biology. 15: e1002596. PMID 28170393 DOI: 10.1371/journal.pbio.1002596  1
2017 Driehuis E, Clevers H. CRISPR/Cas 9 genome editing and its applications in organoids. American Journal of Physiology. Gastrointestinal and Liver Physiology. 312: G257-G265. PMID 28126704 DOI: 10.1152/ajpgi.00410.2016  1
2017 Bredenoord AL, Clevers H, Knoblich JA. Human tissues in a dish: The research and ethical implications of organoid technology. Science (New York, N.Y.). 355. PMID 28104841 DOI: 10.1126/science.aaf9414  1
2017 Hombrink P, Helbig C, Backer RA, Piet B, Oja AE, Stark R, Brasser G, Jongejan A, Jonkers RE, Nota B, Basak O, Clevers HC, Moerland PD, Amsen D, van Lier RA. Erratum: Programs for the persistence, vigilance and control of human CD8(+) lung-resident memory T cells. Nature Immunology. 18: 246. PMID 28102212 DOI: 10.1038/ni0217-246d  1
2017 Cristobal A, van den Toorn HW, van de Wetering M, Clevers H, Heck AJ, Mohammed S. Personalized Proteome Profiles of Healthy and Tumor Human Colon Organoids Reveal Both Individual Diversity and Basic Features of Colorectal Cancer. Cell Reports. 18: 263-274. PMID 28052255 DOI: 10.1016/j.celrep.2016.12.016  1
2016 Basak O, Beumer J, Wiebrands K, Seno H, van Oudenaarden A, Clevers H. Induced Quiescence of Lgr5+ Stem Cells in Intestinal Organoids Enables Differentiation of Hormone-Producing Enteroendocrine Cells. Cell Stem Cell. PMID 27939219 DOI: 10.1016/j.stem.2016.11.001  1
2016 Steinhart Z, Pavlovic Z, Chandrashekhar M, Hart T, Wang X, Zhang X, Robitaille M, Brown KR, Jaksani S, Overmeer R, Boj SF, Adams J, Pan J, Clevers H, Sidhu S, et al. Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors. Nature Medicine. PMID 27869803 DOI: 10.1038/nm.4219  1
2016 Gjorevski N, Sachs N, Manfrin A, Giger S, Bragina ME, Ordóñez-Morán P, Clevers H, Lutolf MP. Designer matrices for intestinal stem cell and organoid culture. Nature. PMID 27851739 DOI: 10.1038/nature20168  1
2016 Verissimo CS, Overmeer RM, Ponsioen B, Drost J, Mertens S, Verlaan-Klink I, van Gerwen B, van der Ven M, Van de Wetering M, Egan DA, Bernards R, Clevers H, Bos JL, Snippert HJ. Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening. Elife. 5. PMID 27845624 DOI: 10.7554/eLife.18489  1
2016 Beumer J, Clevers H. Regulation and plasticity of intestinal stem cells during homeostasis and regeneration. Development (Cambridge, England). 143: 3639-3649. PMID 27802133 DOI: 10.1242/dev.133132  1
2016 Hombrink P, Helbig C, Backer RA, Piet B, Oja AE, Stark R, Brasser G, Jongejan A, Jonkers RE, Nota B, Basak O, Clevers HC, Moerland PD, Amsen D, van Lier RA. Programs for the persistence, vigilance and control of human CD8(+) lung-resident memory T cells. Nature Immunology. 17: 1467-1478. PMID 27776108 DOI: 10.1038/ni.3589  1
2016 Tetteh PW, Kretzschmar K, Begthel H, van den Born M, Korving J, Morsink F, Farin H, van Es JH, Offerhaus GJ, Clevers H. Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research. Proceedings of the National Academy of Sciences of the United States of America. 113: 11859-11864. PMID 27708166 DOI: 10.1073/pnas.1614057113  1
2016 Blokzijl F, de Ligt J, Jager M, Sasselli V, Roerink S, Sasaki N, Huch M, Boymans S, Kuijk E, Prins P, Nijman IJ, Martincorena I, Mokry M, Wiegerinck CL, Middendorp S, ... ... Clevers H, et al. Tissue-specific mutation accumulation in human adult stem cells during life. Nature. PMID 27698416 DOI: 10.1038/nature19768  1
2016 Kretzschmar K, Clevers H. Organoids: Modeling Development and the Stem Cell Niche in a Dish. Developmental Cell. 38: 590-600. PMID 27676432 DOI: 10.1016/j.devcel.2016.08.014  0.01
2016 Drost J, Artegiani B, Clevers H. The Generation of Organoids for Studying Wnt Signaling. Methods in Molecular Biology (Clifton, N.J.). 1481: 141-59. PMID 27590160 DOI: 10.1007/978-1-4939-6393-5_15  1
2016 Sasaki N, Sachs N, Wiebrands K, Ellenbroek SI, Fumagalli A, Lyubimova A, Begthel H, van den Born M, van Es JH, Karthaus WR, Li VS, López-Iglesias C, Peters PJ, van Rheenen J, van Oudenaarden A, ... Clevers H, et al. Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon. Proceedings of the National Academy of Sciences of the United States of America. PMID 27573849 DOI: 10.1073/pnas.1607327113  1
2016 Broutier L, Andersson-Rolf A, Hindley CJ, Boj SF, Clevers H, Koo BK, Huch M. Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation. Nature Protocols. 11: 1724-43. PMID 27560176 DOI: 10.1038/nprot.2016.097  1
2016 Cammareri P, Rose AM, Vincent DF, Wang J, Nagano A, Libertini S, Ridgway RA, Athineos D, Coates PJ, McHugh A, Pourreyron C, Dayal JH, Larsson J, Weidlich S, Spender LC, ... ... Clevers H, et al. Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma. Nature Communications. 7: 12493. PMID 27558455 DOI: 10.1038/ncomms12493  1
2016 Drost J, Clevers H. Who Is in the Driver's Seat: Tracing Cancer Genes Using CRISPR-Barcoding. Molecular Cell. 63: 352-4. PMID 27494556 DOI: 10.1016/j.molcel.2016.07.013  1
2016 Grün D, Muraro MJ, Boisset JC, Wiebrands K, Lyubimova A, Dharmadhikari G, van den Born M, van Es J, Jansen E, Clevers H, de Koning EJ, van Oudenaarden A. De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data. Cell Stem Cell. PMID 27345837 DOI: 10.1016/j.stem.2016.05.010  1
2016 Dekkers JF, Berkers G, Kruisselbrink E, Vonk A, de Jonge HR, Janssens HM, Bronsveld I, van de Graaf EA, Nieuwenhuis EE, Houwen RH, Vleggaar FP, Escher JC, de Rijke YB, Majoor CJ, Heijerman HG, ... ... Clevers H, et al. Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis. Science Translational Medicine. 8: 344ra84. PMID 27334259 DOI: 10.1126/scitranslmed.aad8278  1
2016 Yan HH, Lai JC, Ho SL, Leung WK, Law WL, Lee JF, Chan AK, Tsui WY, Chan AS, Lee BC, Yue SS, Man AH, Clevers H, Yuen ST, Leung SY. RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation. Gut. PMID 27329244 DOI: 10.1136/gutjnl-2016-311849  1
2016 Clevers H. Modeling Development and Disease with Organoids. Cell. 165: 1586-1597. PMID 27315476 DOI: 10.1016/j.cell.2016.05.082  0.01
2016 Boj SF, Hwang CI, Baker LA, Engle DD, Tuveson DA, Clevers H. Model organoids provide new research opportunities for ductal pancreatic cancer. Molecular & Cellular Oncology. 3: e1014757. PMID 27308531 DOI: 10.1080/23723556.2015.1014757  1
2016 Boers SN, van Delden JJ, Clevers H, Bredenoord AL. Organoid biobanking: identifying the ethics: Organoids revive old and raise new ethical challenges for basic research and therapeutic use. Embo Reports. 17: 938-41. PMID 27296278 DOI: 10.15252/embr.201642613  1
2016 Schwank G, Clevers H. CRISPR/Cas9-Mediated Genome Editing of Mouse Small Intestinal Organoids. Methods in Molecular Biology (Clifton, N.J.). 1422: 3-11. PMID 27246017 DOI: 10.1007/978-1-4939-3603-8_1  0.01
2016 Fessler E, Drost J, van Hooff SR, Linnekamp JF, Wang X, Jansen M, De Sousa E Melo F, Prasetyanti PR, IJspeert JE, Franitza M, Nürnberg P, van Noesel CJ, Dekker E, Vermeulen L, Clevers H, et al. TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype. Embo Molecular Medicine. PMID 27221051 DOI: 10.15252/emmm.201606184  1
2016 Dominguez-Brauer C, Hao Z, Elia AJ, Fortin JM, Nechanitzky R, Brauer PM, Sheng Y, Mana MD, Chio II, Haight J, Pollett A, Cairns R, Tworzyanski L, Inoue S, Reardon C, ... ... Clevers H, et al. Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation. Cell Stem Cell. PMID 27184401 DOI: 10.1016/j.stem.2016.04.002  1
2016 Baker LA, Tiriac H, Clevers H, Tuveson DA. Modeling pancreatic cancer with organoids. Trends in Cancer. 2: 176-190. PMID 27135056 DOI: 10.1016/j.trecan.2016.03.004  1
2016 Zhao C, Deng Y, Liu L, Yu K, Zhang L, Wang H, He X, Wang J, Lu C, Wu LN, Weng Q, Mao M, Li J, van Es JH, Xin M, ... ... Clevers H, et al. Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation. Nature Communications. 7: 10883. PMID 26955760 DOI: 10.1038/ncomms10883  1
2016 Kuijk EW, Rasmussen S, Blokzijl F, Huch M, Gehart H, Toonen P, Begthel H, Clevers H, Geurts AM, Cuppen E. Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure. Scientific Reports. 6: 22154. PMID 26915950 DOI: 10.1038/srep22154  1
2016 Farin HF, Jordens I, Mosa MH, Basak O, Korving J, Tauriello DV, de Punder K, Angers S, Peters PJ, Maurice MM, Clevers H. Visualization of a short-range Wnt gradient in the intestinal stem-cell niche. Nature. PMID 26863187 DOI: 10.1038/nature16937  1
2016 Tetteh PW, Basak O, Farin HF, Wiebrands K, Kretzschmar K, Begthel H, van den Born M, Korving J, de Sauvage F, van Es JH, van Oudenaarden A, Clevers H. Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters. Cell Stem Cell. 18: 203-13. PMID 26831517 DOI: 10.1016/j.stem.2016.01.001  1
2016 Drost J, Karthaus WR, Gao D, Driehuis E, Sawyers CL, Chen Y, Clevers H. Organoid culture systems for prostate epithelial and cancer tissue. Nature Protocols. 11: 347-58. PMID 26797458 DOI: 10.1038/nprot.2016.006  1
2016 Karin M, Clevers H. Reparative inflammation takes charge of tissue regeneration. Nature. 529: 307-15. PMID 26791721 DOI: 10.1038/nature17039  1
2016 Maimets M, Rocchi C, Bron R, Pringle S, Kuipers J, Giepmans BN, Vries RG, Clevers H, de Haan G, van Os R, Coppes RP. Long-Term In Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals. Stem Cell Reports. 6: 150-62. PMID 26724906 DOI: 10.1016/j.stemcr.2015.11.009  1
2015 Bartfeld S, Clevers H. Organoids as Model for Infectious Diseases: Culture of Human and Murine Stomach Organoids and Microinjection of Helicobacter Pylori. Journal of Visualized Experiments : Jove. PMID 26650279 DOI: 10.3791/53359  1
2015 Agarwal S, Hynes PG, Tillman HS, Lake R, Abou-Kheir WG, Fang L, Casey OM, Ameri AH, Martin PL, Yin JJ, Iaquinta PJ, Karthaus WR, Clevers HC, Sawyers CL, Kelly K. Identification of Different Classes of Luminal Progenitor Cells within Prostate Tumors. Cell Reports. 13: 2147-58. PMID 26628377 DOI: 10.1016/j.celrep.2015.10.077  1
2015 Füllgrabe A, Joost S, Are A, Jacob T, Sivan U, Haegebarth A, Linnarsson S, Simons BD, Clevers H, Toftgård R, Kasper M. Dynamics of Lgr6(+) Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis. Stem Cell Reports. PMID 26607954 DOI: 10.1016/j.stemcr.2015.09.013  1
2015 Kabouridis PS, Lasrado R, McCallum S, Chng SH, Snippert HJ, Clevers H, Pettersson S, Pachnis V. The gut microbiota keeps enteric glial cells on the move; prospective roles of the gut epithelium and immune system. Gut Microbes. 0. PMID 26558327 DOI: 10.1080/19490976.2015.1109767  1
2015 Weeber F, van de Wetering M, Hoogstraat M, Dijkstra KK, Krijgsman O, Kuilman T, Gadellaa-van Hooijdonk CG, van der Velden DL, Peeper DS, Cuppen EP, Vries RG, Clevers H, Voest EE. Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases. Proceedings of the National Academy of Sciences of the United States of America. 112: 13308-11. PMID 26460009 DOI: 10.1073/pnas.1516689112  1
2015 Nantasanti S, Spee B, Kruitwagen HS, Chen C, Geijsen N, Oosterhoff LA, van Wolferen ME, Pelaez N, Fieten H, Wubbolts RW, Grinwis GC, Chan J, Huch M, Vries RR, Clevers H, et al. Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids. Stem Cell Reports. PMID 26455412 DOI: 10.1016/j.stemcr.2015.09.002  1
2015 Hwang CI, Boj SF, Clevers H, Tuveson DA. Pre-clinical Models of Pancreatic Ductal Adenocarcinoma. The Journal of Pathology. PMID 26419819 DOI: 10.1002/path.4651  1
2015 Schneeberger K, Vogel GF, Teunissen H, van Ommen DD, Begthel H, El Bouazzaoui L, van Vugt AH, Beekman JM, Klumperman J, Müller T, Janecke A, Gerner P, Huber LA, Hess MW, Clevers H, et al. An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral trafficking. Proceedings of the National Academy of Sciences of the United States of America. PMID 26392529 DOI: 10.1073/pnas.1516672112  1
2015 Grün D, Lyubimova A, Kester L, Wiebrands K, Basak O, Sasaki N, Clevers H, van Oudenaarden A. Single-cell messenger RNA sequencing reveals rare intestinal cell types. Nature. 525: 251-5. PMID 26287467 DOI: 10.1038/nature14966  1
2015 Rookmaaker MB, Schutgens F, Verhaar MC, Clevers H. Development and application of human adult stem or progenitor cell organoids. Nature Reviews. Nephrology. 11: 546-54. PMID 26215513 DOI: 10.1038/nrneph.2015.118  0.01
2015 Heo I, Clevers H. Expanding intestinal stem cells in culture. Cell Research. 25: 995-6. PMID 26169607 DOI: 10.1038/cr.2015.83  1
2015 Sato T, Clevers H. SnapShot: Growing Organoids from Stem Cells. Cell. 161: 1700-1700.e1. PMID 26091044 DOI: 10.1016/j.cell.2015.06.028  0.01
2015 Dow LE, O'Rourke KP, Simon J, Tschaharganeh DF, van Es JH, Clevers H, Lowe SW. Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer. Cell. 161: 1539-52. PMID 26091037 DOI: 10.1016/j.cell.2015.05.033  1
2015 Koo BK, van Es JH, van den Born M, Clevers H. Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia. Proceedings of the National Academy of Sciences of the United States of America. 112: 7548-50. PMID 26023187 DOI: 10.1073/pnas.1508113112  1
2015 van de Wetering M, Francies HE, Francis JM, Bounova G, Iorio F, Pronk A, van Houdt W, van Gorp J, Taylor-Weiner A, Kester L, McLaren-Douglas A, Blokker J, Jaksani S, Bartfeld S, Volckman R, ... ... Clevers H, et al. Prospective derivation of a living organoid biobank of colorectal cancer patients. Cell. 161: 933-45. PMID 25957691 DOI: 10.1016/j.cell.2015.03.053  1
2015 Drost J, van Jaarsveld RH, Ponsioen B, Zimberlin C, van Boxtel R, Buijs A, Sachs N, Overmeer RM, Offerhaus GJ, Begthel H, Korving J, van de Wetering M, Schwank G, Logtenberg M, Cuppen E, ... ... Clevers H, et al. Sequential cancer mutations in cultured human intestinal stem cells. Nature. 521: 43-7. PMID 25924068 DOI: 10.1038/nature14415  1
2015 D'Astolfo DS, Pagliero RJ, Pras A, Karthaus WR, Clevers H, Prasad V, Lebbink RJ, Rehmann H, Geijsen N. Efficient intracellular delivery of native proteins. Cell. 161: 674-90. PMID 25910214 DOI: 10.1016/j.cell.2015.03.028  1
2015 Flanagan DJ, Phesse TJ, Barker N, Schwab RH, Amin N, Malaterre J, Stange DE, Nowell CJ, Currie SA, Saw JT, Beuchert E, Ramsay RG, Sansom OJ, Ernst M, Clevers H, et al. Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5(+) stem cells. Stem Cell Reports. 4: 759-67. PMID 25892522 DOI: 10.1016/j.stemcr.2015.03.003  1
2015 Kundu P, Genander M, Strååt K, Classon J, Ridgway RA, Tan EH, Björk J, Martling A, van Es J, Sansom OJ, Clevers H, Pettersson S, Frisén J. An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth. Science Translational Medicine. 7: 281ra44. PMID 25834110 DOI: 10.1126/scitranslmed.3010567  1
2015 Baggiolini A, Varum S, Mateos JM, Bettosini D, John N, Bonalli M, Ziegler U, Dimou L, Clevers H, Furrer R, Sommer L. Premigratory and migratory neural crest cells are multipotent in vivo. Cell Stem Cell. 16: 314-22. PMID 25748934 DOI: 10.1016/j.stem.2015.02.017  1
2015 Weren RD, Venkatachalam R, Cazier JB, Farin HF, Kets CM, de Voer RM, Vreede L, Verwiel ET, van Asseldonk M, Kamping EJ, Kiemeney LA, Neveling K, Aben KK, Carvajal-Carmona L, Nagtegaal ID, ... ... Clevers H, et al. Germline deletions in the tumour suppressor gene FOCAD are associated with polyposis and colorectal cancer development. The Journal of Pathology. 236: 155-64. PMID 25712196 DOI: 10.1002/path.4520  1
2015 van Es JH, Clevers H. Generation and analysis of mouse intestinal tumors and organoids harboring APC and K-Ras mutations. Methods in Molecular Biology (Clifton, N.J.). 1267: 125-44. PMID 25636467 DOI: 10.1007/978-1-4939-2297-0_6  1
2015 Schuijers J, Junker JP, Mokry M, Hatzis P, Koo BK, Sasselli V, van der Flier LG, Cuppen E, van Oudenaarden A, Clevers H. Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts. Cell Stem Cell. 16: 158-70. PMID 25620640 DOI: 10.1016/j.stem.2014.12.006  1
2015 Kabouridis PS, Lasrado R, McCallum S, Chng SH, Snippert HJ, Clevers H, Pettersson S, Pachnis V. Microbiota controls the homeostasis of glial cells in the gut lamina propria. Neuron. 85: 289-95. PMID 25578362 DOI: 10.1016/j.neuron.2014.12.037  1
2015 Boj SF, Hwang CI, Baker LA, Chio II, Engle DD, Corbo V, Jager M, Ponz-Sarvise M, Tiriac H, Spector MS, Gracanin A, Oni T, Yu KH, van Boxtel R, Huch M, ... ... Clevers H, et al. Organoid models of human and mouse ductal pancreatic cancer. Cell. 160: 324-38. PMID 25557080 DOI: 10.1016/j.cell.2014.12.021  1
2014 Karthaus WR, Iaquinta PJ, Drost J, Gracanin A, van Boxtel R, Wongvipat J, Dowling CM, Gao D, Begthel H, Sachs N, Vries RG, Cuppen E, Chen Y, Sawyers CL, Clevers HC. Identification of multipotent luminal progenitor cells in human prostate organoid cultures. Cell. 159: 163-75. PMID 25201529 DOI: 10.1016/j.cell.2014.08.017  1
2014 Clevers JC. [Stop the compulsive PhD trajectory for junior doctors]. Nederlands Tijdschrift Voor Geneeskunde. 158: A7669. PMID 24893817  0.48
2014 Forrest AR, Kawaji H, Rehli M, Baillie JK, de Hoon MJ, Haberle V, Lassmann T, Kulakovskiy IV, Lizio M, Itoh M, Andersson R, Mungall CJ, Meehan TF, Schmeier S, ... ... Clevers HC, et al. A promoter-level mammalian expression atlas. Nature. 507: 462-70. PMID 24670764 DOI: 10.1038/nature13182  1
2013 de Groot RE, Farin HF, Macůrková M, van Es JH, Clevers HC, Korswagen HC. Retromer dependent recycling of the Wnt secretion factor Wls is dispensable for stem cell maintenance in the mammalian intestinal epithelium. Plos One. 8: e76971. PMID 24130821 DOI: 10.1371/journal.pone.0076971  1
2013 Kaaij LT, van de Wetering M, Fang F, Decato B, Molaro A, van de Werken HJ, van Es JH, Schuijers J, de Wit E, de Laat W, Hannon GJ, Clevers HC, Smith AD, Ketting RF. DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus. Genome Biology. 14: R50. PMID 23714178 DOI: 10.1186/gb-2013-14-5-r50  1
2013 Clevers HC, Bevins CL. Paneth cells: maestros of the small intestinal crypts. Annual Review of Physiology. 75: 289-311. PMID 23398152 DOI: 10.1146/annurev-physiol-030212-183744  0.08
2012 de Lau WB, Snel B, Clevers HC. The R-spondin protein family. Genome Biology. 13: 242. PMID 22439850 DOI: 10.1186/gb-2012-13-3-242  1
2009 van Stralen E, van de Wetering M, Agnelli L, Neri A, Clevers HC, Bast BJ. Identification of primary MAFB target genes in multiple myeloma. Experimental Hematology. 37: 78-86. PMID 19013005 DOI: 10.1016/j.exphem.2008.08.006  1
2007 van Noort M, Weerkamp F, Clevers HC, Staal FJ. Wnt signaling and phosphorylation status of beta-catenin: importance of the correct antibody tools. Blood. 110: 2778-9. PMID 17881649 DOI: 10.1182/blood-2007-05-092445  1
2006 Haramis AP, Hurlstone A, van der Velden Y, Begthel H, van den Born M, Offerhaus GJ, Clevers HC. Adenomatous polyposis coli-deficient zebrafish are susceptible to digestive tract neoplasia. Embo Reports. 7: 444-9. PMID 16439994 DOI: 10.1038/sj.embor.7400638  1
2005 Staal FJ, Clevers HC. WNT signalling and haematopoiesis: a WNT-WNT situation. Nature Reviews. Immunology. 5: 21-30. PMID 15630426 DOI: 10.1038/nri1529  1
2004 Boersma-Vreugdenhil GR, Kuipers J, Van Stralen E, Peeters T, Michaux L, Hagemeijer A, Pearson PL, Clevers HC, Bast BJ. The recurrent translocation t(14;20)(q32;q12) in multiple myeloma results in aberrant expression of MAFB: a molecular and genetic analysis of the chromosomal breakpoint. British Journal of Haematology. 126: 355-63. PMID 15257707 DOI: 10.1111/j.1365-2141.2004.05050.x  1
2004 Baas AF, Kuipers J, van der Wel NN, Batlle E, Koerten HK, Peters PJ, Clevers HC. Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. Cell. 116: 457-66. PMID 15016379  1
2003 Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, Prescott AR, Clevers HC, Alessi DR. MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. The Embo Journal. 22: 5102-14. PMID 14517248 DOI: 10.1093/emboj/cdg490  1
2003 Baas AF, Boudeau J, Sapkota GP, Smit L, Medema R, Morrice NA, Alessi DR, Clevers HC. Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD Embo Journal. 22: 3062-3072. PMID 12805220 DOI: 10.1093/emboj/cdg292  1
2003 Staal FJ, Clevers HC. Wnt signaling in the thymus. Current Opinion in Immunology. 15: 204-8. PMID 12633671  1
2002 Oving IM, Clevers HC. Molecular causes of colon cancer. European Journal of Clinical Investigation. 32: 448-57. PMID 12059991  0.01
2002 Korswagen HC, Coudreuse DY, Betist MC, van de Water S, Zivkovic D, Clevers HC. The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans. Genes & Development. 16: 1291-302. PMID 12023307 DOI: 10.1101/gad.981802  1
2002 Staal FJ, van Noort M, Strous GJ, Clevers HC. Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin. Embo Reports. 3: 63-8. PMID 11751573 DOI: 10.1093/embo-reports/kvf002  1
2001 van Es JH, Giles RH, Clevers HC. The many faces of the tumor suppressor gene APC. Experimental Cell Research. 264: 126-34. PMID 11237529 DOI: 10.1006/excr.2000.5142  1
2000 Korswagen HC, Herman MA, Clevers HC. Distinct beta-catenins mediate adhesion and signalling functions in C. elegans. Nature. 406: 527-32. PMID 10952315 DOI: 10.1038/35020099  1
1999 Korswagen HC, Clevers HC. Activation and repression of wingless/Wnt target genes by the TCF/LEF-1 family of transcription factors. Cold Spring Harbor Symposia On Quantitative Biology. 64: 141-7. PMID 11232279  1
1999 Staal FJ, Burgering BM, van de Wetering M, Clevers HC. Tcf-1-mediated transcription in T lymphocytes: differential role for glycogen synthase kinase-3 in fibroblasts and T cells. International Immunology. 11: 317-23. PMID 10221643  1
1998 de Lau WB, Hurenkamp J, Berendes P, Touw IP, Clevers HC, van Dijk MA. The gene encoding the granulocyte colony-stimulating factor receptor is a target for deregulation in pre-B ALL by the t(1;19)-specific oncoprotein E2A-Pbx1. Oncogene. 17: 503-10. PMID 9696044 DOI: 10.1038/sj.onc.1201967  1
1997 Schilham MW, Moerer P, Cumano A, Clevers HC. Sox-4 facilitates thymocyte differentiation. European Journal of Immunology. 27: 1292-5. PMID 9174623 DOI: 10.1002/eji.1830270534  1
1996 Petersen EJ, Rozenberg-Arska M, Dekker AW, Clevers HC, Verdonck LF. Allogeneic bone marrow transplantation can restore CD4+ T-lymphocyte count and immune function in idiopathic CD4+ T-lymphocytopenia. Bone Marrow Transplantation. 18: 813-5. PMID 8899203  1
1996 Clevers HC, Grosschedl R. Transcriptional control of lymphoid development: lessons from gene targeting. Immunology Today. 17: 336-43. PMID 8763820  0.04
1994 Wijngaard PL, MacHugh ND, Metzelaar MJ, Romberg S, Bensaid A, Pepin L, Davis WC, Clevers HC. Members of the novel WC1 gene family are differentially expressed on subsets of bovine CD4-CD8- gamma delta T lymphocytes. Journal of Immunology (Baltimore, Md. : 1950). 152: 3476-82. PMID 7511649  1
1993 Schilham MW, van Eijk M, van de Wetering M, Clevers HC. The murine Sox-4 protein is encoded on a single exon. Nucleic Acids Research. 21: 2009. PMID 8493110  1
1993 Schuurman HJ, Hu HZ, de Weger RA, Clevers HC. Thoughts on the thymus and the T-lymphocyte repertoire. Relevance to the tolerance of the immune response. The Netherlands Journal of Medicine. 43: 38-54. PMID 8232693  0.04
1993 Clevers HC, Oosterwegel MA, Georgopoulos K. Transcription factors in early T-cell development. Immunology Today. 14: 591-6. PMID 7905739 DOI: 10.1016/0167-5699(93)90198-T  1
1992 Gastrop J, Hoevenagel R, Young JR, Clevers HC. A common ancestor of the mammalian transcription factors TCF-1 and TCF-1 alpha/LEF-1 expressed in chicken T cells. European Journal of Immunology. 22: 1327-30. PMID 1577072 DOI: 10.1002/eji.1830220531  0.01
1992 Metzelaar MJ, Clevers HC. Lysosomal membrane glycoproteins in platelets. Thrombosis and Haemostasis. 68: 378-82. PMID 1448767  1
1992 Wijngaard PL, Metzelaar MJ, MacHugh ND, Morrison WI, Clevers HC. Molecular characterization of the WC1 antigen expressed specifically on bovine CD4-CD8- gamma delta T lymphocytes. Journal of Immunology (Baltimore, Md. : 1950). 149: 3273-7. PMID 1431105  1
1991 Metzelaar MJ, Wijngaard PL, Peters PJ, Sixma JJ, Nieuwenhuis HK, Clevers HC. CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells. The Journal of Biological Chemistry. 266: 3239-45. PMID 1993697  1
1991 Oosterwegel MA, van de Wetering ML, Holstege FC, Prosser HM, Owen MJ, Clevers HC. TCF-1, a T cell-specific transcription factor of the HMG box family, interacts with sequence motifs in the TCR beta and TCR delta enhancers. International Immunology. 3: 1189-92. PMID 1836958  1
1991 Clevers HC, Owen MJ. Towards a molecular understanding of T-cell differentiation. Immunology Today. 12: 86-92. PMID 1676267 DOI: 10.1016/0167-5699(91)90163-N  1
1989 Peters PJ, Geuze HJ, Van der Donk HA, Slot JW, Griffith JM, Stam NJ, Clevers HC, Borst J. Molecules relevant for T cell-target cell interaction are present in cytolytic granules of human T lymphocytes. European Journal of Immunology. 19: 1469-75. PMID 2789142 DOI: 10.1002/eji.1830190819  1
1989 Clevers H, Lonberg N, Dunlap S, Lacy E, Terhorst C. An enhancer located in a CpG-island 3' to the TCR/CD3-epsilon gene confers T lymphocyte-specificity to its promoter. The Embo Journal. 8: 2527-35. PMID 2583122  1
1988 Clevers H, Alarcon B, Wileman T, Terhorst C. The T cell receptor/CD3 complex: a dynamic protein ensemble. Annual Review of Immunology. 6: 629-62. PMID 3289580 DOI: 10.1146/annurev.iy.06.040188.003213  1
1988 Clevers HC, Dunlap S, Wileman TE, Terhorst C. Human CD3-epsilon gene contains three miniexons and is transcribed from a non-TATA promoter. Proceedings of the National Academy of Sciences of the United States of America. 85: 8156-60. PMID 3267235  1
1988 Clevers H, Dunlap S, Saito H, Georgopoulos K, Wileman T, Terhorst C. Characterization and expression of the murine CD3-epsilon gene. Proceedings of the National Academy of Sciences of the United States of America. 85: 8623-7. PMID 2973066  1
1988 Clevers H, Dunlap S, Terhorst C. The transmembrane orientation of the epsilon chain of the TcR/CD3 complex. European Journal of Immunology. 18: 705-10. PMID 2967760 DOI: 10.1002/eji.1830180508  1
1987 Gold DP, Clevers H, Alarcon B, Dunlap S, Novotny J, Williams AF, Terhorst C. Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family. Proceedings of the National Academy of Sciences of the United States of America. 84: 7649-53. PMID 3478717  1
1987 Saito H, Koyama T, Georgopoulos K, Clevers H, Haser WG, LeBien T, Tonegawa S, Terhorst C. Close linkage of the mouse and human CD3 gamma- and delta-chain genes suggests that their transcription is controlled by common regulatory elements. Proceedings of the National Academy of Sciences of the United States of America. 84: 9131-4. PMID 2827170  1
1986 Bloem AC, Clevers JC, Bast EJ, Ballieux RE. T cells in B cell chronic lymphocytic leukaemia. I. Decreased frequency of T lymphocytes secreting suppressor factor. Clinical and Experimental Immunology. 63: 188-93. PMID 3485483  0.48
1986 Clevers HC, de Bresser A, Kleinveld H, Gmelig-Meyling FH, Ballieux RE. Wheat germ agglutinin activates human T lymphocytes by stimulation of phosphoinositide hydrolysis. Journal of Immunology (Baltimore, Md. : 1950). 136: 3180-3. PMID 3007612  1
1985 Clevers HC, Hoeksema M, Gmelig-Meyling FH, Ballieux RE. Calcium ionophore A23187 induces interleukin 2 reactivity in human T cells. Scandinavian Journal of Immunology. 22: 633-8. PMID 3937226  1
1985 Clevers HC, Versteegen JM, Logtenberg T, Gmelig-Meyling FH, Ballieux RE. Synergistic action of A23187 and phorbol ester on human B cell activation. Journal of Immunology (Baltimore, Md. : 1950). 135: 3827-30. PMID 3934268  1
1985 Clevers HC, Bloem AC, Gmelig-Meyling F, Ballieux RE. Ligands of surface Ig raise cytoplasmic free Ca++ in human B cells. Scandinavian Journal of Immunology. 22: 557-62. PMID 3878580  1
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