Lude Hendrikus Franke - Publications

Affiliations: 
Genetics University of Groningen, Groningen, Netherlands 
Website:
https://www.rug.nl/staff/l.h.franke/cv

149 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Zhernakova DV, Le TH, Kurilshikov A, Atanasovska B, Bonder MJ, Sanna S, Claringbould A, Võsa U, Deelen P, Franke L, de Boer RA, Kuipers F, Netea MG, Hofker MH, Wijmenga C, et al. Author Correction: Individual variations in cardiovascular-disease-related protein levels are driven by genetics and gut microbiome. Nature Genetics. PMID 30341443 DOI: 10.1038/s41588-018-0275-9  1
2018 Zhernakova DV, Le TH, Kurilshikov A, Atanasovska B, Bonder MJ, Sanna S, Claringbould A, Võsa U, Deelen P, Franke L, de Boer RA, Kuipers F, Netea MG, et al. Individual variations in cardiovascular-disease-related protein levels are driven by genetics and gut microbiome. Nature Genetics. PMID 30250126 DOI: 10.1038/s41588-018-0224-7  1
2018 Luijk R, Wu H, Ward-Caviness CK, Hannon E, Carnero-Montoro E, Min JL, Mandaviya P, Müller-Nurasyid M, Mei H, van der Maarel SM, Relton C, Mill J, Waldenberger M, Bell JT, ... ... Franke L, et al. Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation. Nature Communications. 9: 3738. PMID 30218040 DOI: 10.1038/s41467-018-05714-3  1
2018 Luijk R, Dekkers KF, van Iterson M, Arindrarto W, Claringbould A, Hop P, Boomsma DI, van Duijn CM, van Greevenbroek MMJ, Veldink JH, Wijmenga C, Franke L, 't Hoen PAC, Jansen R, et al. Genome-wide identification of directed gene networks using large-scale population genomics data. Nature Communications. 9: 3097. PMID 30082726 DOI: 10.1038/s41467-018-05452-6  1
2018 van Setten J, Brody JA, Jamshidi Y, Swenson BR, Butler AM, Campbell H, Del Greco FM, Evans DS, Gibson Q, Gudbjartsson DF, Kerr KF, Krijthe BP, Lyytikäinen LP, Müller C, Müller-Nurasyid M, ... ... Franke L, et al. PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity. Nature Communications. 9: 2904. PMID 30046033 DOI: 10.1038/s41467-018-04766-9  1
2018 Wang J, Kurilshikov A, Radjabzadeh D, Turpin W, Croitoru K, Bonder MJ, Jackson MA, Medina-Gomez C, Frost F, Homuth G, Rühlemann M, Hughes D, Kim HN, Spector TD, ... ... Franke L, et al. Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative. Microbiome. 6: 101. PMID 29880062 DOI: 10.1186/s40168-018-0479-3  1
2018 Bakker OB, Aguirre-Gamboa R, Sanna S, Oosting M, Smeekens SP, Jaeger M, Zorro M, Võsa U, Withoff S, Netea-Maier RT, Koenen HJPM, Joosten I, Xavier RJ, Franke L, Joosten LAB, et al. Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses. Nature Immunology. PMID 29784908 DOI: 10.1038/s41590-018-0121-3  1
2018 van der Wijst MGP, Brugge H, de Vries DH, Deelen P, Swertz MA, Franke L. Single-cell RNA sequencing identifies celltype-specific cis-eQTLs and co-expression QTLs. Nature Genetics. 50: 493-497. PMID 29610479 DOI: 10.1038/s41588-018-0089-9  1
2018 Yousefi S, Abbassi-Daloii T, Kraaijenbrink T, Vermaat M, Mei H, van 't Hof P, van Iterson M, Zhernakova DV, Claringbould A, Franke L, 't Hart LM, Slieker RC, van der Heijden A, de Knijff P, et al. A SNP panel for identification of DNA and RNA specimens. Bmc Genomics. 19: 90. PMID 29370748 DOI: 10.1186/s12864-018-4482-7  1
2017 Karlsson Linnér R, Marioni RE, Rietveld CA, Simpkin AJ, Davies NM, Watanabe K, Armstrong NJ, Auro K, Baumbach C, Bonder MJ, Buchwald J, Fiorito G, Ismail K, Iurato S, Joensuu A, ... ... Franke L, et al. An epigenome-wide association study meta-analysis of educational attainment. Molecular Psychiatry. PMID 29086770 DOI: 10.1038/mp.2017.210  1
2017 Mandaviya PR, Joehanes R, Aïssi D, Kühnel B, Marioni RE, Truong V, Stolk L, Beekman M, Bonder MJ, Franke L, Gieger C, Huan T, Ikram MA, Kunze S, Liang L, et al. Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes. Plos One. 12: e0182472. PMID 29084233 DOI: 10.1371/journal.pone.0182472  1
2017 Nibbeling EAR, Duarri A, Verschuuren-Bemelmans CC, Fokkens MR, Karjalainen JM, Smeets CJLM, de Boer-Bergsma JJ, van der Vries G, Dooijes D, Bampi GB, van Diemen C, Brunt E, Ippel E, Kremer B, Vlak M, ... ... Franke L, et al. Exome sequencing and network analysis identifies shared mechanisms underlying spinocerebellar ataxia. Brain : a Journal of Neurology. PMID 29053796 DOI: 10.1093/brain/awx251  1
2017 Macé A, Tuke MA, Deelen P, Kristiansson K, Mattsson H, Nõukas M, Sapkota Y, Schick U, Porcu E, Rüeger S, McDaid AF, Porteous D, Winkler TW, Salvi E, Shrine N, ... ... Franke L, et al. CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits. Nature Communications. 8: 744. PMID 28963451 DOI: 10.1038/s41467-017-00556-x  1
2017 Matzaraki V, Gresnigt MS, Jaeger M, Ricaño-Ponce I, Johnson MD, Oosting M, Franke L, Withoff S, Perfect JR, Joosten LAB, Kullberg BJ, van de Veerdonk FL, Jonkers I, Li Y, Wijmenga C, et al. An integrative genomics approach identifies novel pathways that influence candidaemia susceptibility. Plos One. 12: e0180824. PMID 28727728 DOI: 10.1371/journal.pone.0180824  1
2017 Day FR, Thompson DJ, Helgason H, Chasman DI, Finucane H, Sulem P, Ruth KS, Whalen S, Sarkar AK, Albrecht E, Altmaier E, Amini M, Barbieri CM, Boutin T, Campbell A, ... ... Franke L, et al. Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. Nature Genetics. PMID 28436984 DOI: 10.1038/ng.3841  1
2017 Nolte IM, van der Most PJ, Alizadeh BZ, de Bakker PI, Boezen HM, Bruinenberg M, Franke L, van der Harst P, Navis G, Postma DS, Rots MG, Stolk RP, Swertz MA, Wolffenbuttel BH, Wijmenga C, et al. Missing heritability: is the gap closing? An analysis of 32 complex traits in the Lifelines Cohort Study. European Journal of Human Genetics : Ejhg. PMID 28401901 DOI: 10.1038/ejhg.2017.50  1
2017 Wild PS, Felix JF, Schillert A, Teumer A, Chen MH, Leening MJ, Völker U, Großmann V, Brody JA, Irvin MR, Shah SJ, Pramana S, Lieb W, Schmidt R, Stanton AV, ... ... Franke L, et al. Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function. The Journal of Clinical Investigation. PMID 28394258 DOI: 10.1172/JCI84840  1
2017 Kasela S, Kisand K, Tserel L, Kaleviste E, Remm A, Fischer K, Esko T, Westra HJ, Fairfax BP, Makino S, Knight JC, Franke L, Metspalu A, Peterson P, Milani L. Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4+ versus CD8+ T cells. Plos Genetics. 13: e1006643. PMID 28248954 DOI: 10.1371/journal.pgen.1006643  1
2017 Kreiner E, Waage J, Standl M, Brix S, Pers TH, Couto Alves A, Warrington NM, Tiesler CM, Fuertes E, Franke L, Hirschhorn JN, James A, Simpson A, Tung JY, Koppelman GH, et al. Shared genetic variants suggest common pathways in allergy and autoimmune diseases. The Journal of Allergy and Clinical Immunology. PMID 28188724 DOI: 10.1016/j.jaci.2016.10.055  1
2017 van der Velde KJ, de Boer EN, van Diemen CC, Sikkema-Raddatz B, Abbott KM, Knopperts A, Franke L, Sijmons RH, de Koning TJ, Wijmenga C, Sinke RJ, Swertz MA. GAVIN: Gene-Aware Variant INterpretation for medical sequencing. Genome Biology. 18: 6. PMID 28093075 DOI: 10.1186/s13059-016-1141-7  1
2016 Wahl S, Drong A, Lehne B, Loh M, Scott WR, Kunze S, Tsai PC, Ried JS, Zhang W, Yang Y, Tan S, Fiorito G, Franke L, Guarrera S, Kasela S, et al. Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity. Nature. PMID 28002404 DOI: 10.1038/nature20784  1
2016 Amini M, Bashirova D, Prins BP, Corpeleijn E, Bruinenberg M, Franke L, Harst PV, Navis G, Wolffenbuttel BH, Stolk RP, Wijmenga C, Postma DS, Koppelman GH, Boezen HM, et al. Eosinophil Count Is a Common Factor for Complex Metabolic and Pulmonary Traits and Diseases: The LifeLines Cohort Study. Plos One. 11: e0168480. PMID 27978545 DOI: 10.1371/journal.pone.0168480  1
2016 Bonder MJ, Luijk R, Zhernakova DV, Moed M, Deelen P, Vermaat M, van Iterson M, van Dijk F, van Galen M, Bot J, Slieker RC, Jhamai PM, Verbiest M, Suchiman HE, Verkerk M, ... ... Franke L, et al. Disease variants alter transcription factor levels and methylation of their binding sites. Nature Genetics. PMID 27918535 DOI: 10.1038/ng.3721  1
2016 Zhernakova DV, Deelen P, Vermaat M, van Iterson M, van Galen M, Arindrarto W, van 't Hof P, Mei H, van Dijk F, Westra HJ, Bonder MJ, van Rooij J, Verkerk M, Jhamai PM, Moed M, ... ... Franke L, et al. Identification of context-dependent expression quantitative trait loci in whole blood. Nature Genetics. PMID 27918533 DOI: 10.1038/ng.3737  1
2016 Kogelman LJ, Fu J, Franke L, Greve JW, Hofker M, Rensen SS, Kadarmideen HN. Inter-Tissue Gene Co-Expression Networks between Metabolically Healthy and Unhealthy Obese Individuals. Plos One. 11: e0167519. PMID 27907186 DOI: 10.1371/journal.pone.0167519  1
2016 Okbay A, Baselmans BM, De Neve JE, Turley P, Nivard MG, Fontana MA, Meddens SF, Linnér RK, Rietveld CA, Derringer J, Gratten J, Lee JJ, Liu JZ, de Vlaming R, Ahluwalia TS, ... ... Franke L, et al. Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nature Genetics. 48: 1591. PMID 27898078 DOI: 10.1038/ng1216-1587b  1
2016 Aguirre-Gamboa R, Joosten I, Urbano PC, van der Molen RG, van Rijssen E, van Cranenbroek B, Oosting M, Smeekens S, Jaeger M, Zorro M, Withoff S, van Herwaarden AE, Sweep FC, Netea RT, Swertz MA, ... Franke L, et al. Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits. Cell Reports. PMID 27818087 DOI: 10.1016/j.celrep.2016.10.053  1
2016 Li Y, Oosting M, Smeekens SP, Jaeger M, Aguirre-Gamboa R, Le KT, Deelen P, Ricaño-Ponce I, Schoffelen T, Jansen AF, Swertz MA, Withoff S, van de Vosse E, van Deuren M, van de Veerdonk F, ... ... Franke L, et al. A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans. Cell. 167: 1099-1110.e14. PMID 27814507 DOI: 10.1016/j.cell.2016.10.017  1
2016 Imhann F, Vich Vila A, Bonder MJ, Fu J, Gevers D, Visschedijk MC, Spekhorst LM, Alberts R, Franke L, van Dullemen HM, Ter Steege RW, Huttenhower C, Dijkstra G, Xavier RJ, Festen EA, et al. Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease. Gut. PMID 27802154 DOI: 10.1136/gutjnl-2016-312135  1
2016 Barban N, Jansen R, de Vlaming R, Vaez A, Mandemakers JJ, Tropf FC, Shen X, Wilson JF, Chasman DI, Nolte IM, Tragante V, van der Laan SW, Perry JR, Kong A, ... ... Franke L, et al. Genome-wide analysis identifies 12 loci influencing human reproductive behavior. Nature Genetics. PMID 27798627 DOI: 10.1038/ng.3698  1
2016 Kassam I, Qi T, Lloyd-Jones L, Holloway A, Bonder MJ, Henders AK, Martin NG, Powell JE, Franke L, Montgomery GW, Visscher PM, McRae AF. Evidence for mitochondrial genetic control of autosomal gene expression. Human Molecular Genetics. PMID 27798101 DOI: 10.1093/hmg/ddw347  1
2016 Li Y, Oosting M, Deelen P, Ricaño-Ponce I, Smeekens S, Jaeger M, Matzaraki V, Swertz MA, Xavier RJ, Franke L, Wijmenga C, Joosten LA, Kumar V, Netea MG. Corrigendum: Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi. Nature Medicine. 22: 1192. PMID 27711068 DOI: 10.1038/nm1016-1192b  1
2016 Bonder MJ, Kurilshikov A, Tigchelaar EF, Mujagic Z, Imhann F, Vila AV, Deelen P, Vatanen T, Schirmer M, Smeekens SP, Zhernakova DV, Jankipersadsing SA, Jaeger M, Oosting M, Cenit MC, ... ... Franke L, et al. The effect of host genetics on the gut microbiome. Nature Genetics. PMID 27694959 DOI: 10.1038/ng.3663  1
2016 Gormley P, Anttila V, Winsvold BS, Palta P, Esko T, Pers TH, Farh KH, Cuenca-Leon E, Muona M, Furlotte NA, Kurth T, Ingason A, McMahon G, Ligthart L, Terwindt GM, ... ... Franke L, et al. Corrigendum: Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nature Genetics. 48: 1296. PMID 27681292 DOI: 10.1038/ng1016-1296c  1
2016 Iotchkova V, Huang J, Morris JA, Jain D, Barbieri C, Walter K, Min JL, Chen L, Astle W, Cocca M, Deelen P, Elding H, Farmaki AE, Franklin CS, Franberg M, ... ... Franke L, et al. Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps. Nature Genetics. PMID 27668658 DOI: 10.1038/ng.3668  1
2016 van der Harst P, van Setten J, Verweij N, Vogler G, Franke L, Maurano MT, Wang X, Mateo Leach I, Eijgelsheim M, Sotoodehnia N, Hayward C, Sorice R, Meirelles O, Lyytikäinen LP, Polašek O, et al. 52 Genetic Loci Influencing Myocardial Mass. Journal of the American College of Cardiology. 68: 1435-48. PMID 27659466 DOI: 10.1016/j.jacc.2016.07.729  1
2016 Slieker RC, van Iterson M, Luijk R, Beekman M, Zhernakova DV, Moed MH, Mei H, van Galen M, Deelen P, Bonder MJ, Zhernakova A, Uitterlinden AG, Tigchelaar EF, Stehouwer CD, Schalkwijk CG, ... ... Franke L, et al. Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms. Genome Biology. 17: 191. PMID 27654999 DOI: 10.1186/s13059-016-1053-6  1
2016 Netea MG, Joosten LA, Li Y, Kumar V, Oosting M, Smeekens S, Jaeger M, Ter Horst R, Schirmer M, Vlamakis H, Notebaart R, Pavelka N, Aguirre-Gamboa RR, Swertz MA, Tunjungputri RN, ... ... Franke L, et al. Understanding human immune function using the resources from the Human Functional Genomics Project. Nature Medicine. 22: 831-833. PMID 27490433 DOI: 10.1038/nm.4140  1
2016 Okbay A, Baselmans BM, Neve JE, Turley P, Nivard MG, Fontana MA, Meddens SF, Linnér RK, Rietveld CA, Derringer J, Gratten J, Lee JJ, Liu JZ, de Vlaming R, Ahluwalia TS, ... ... Franke L, et al. Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nature Genetics. 48: 970. PMID 27463399 DOI: 10.1038/ng0816-970c  1
2016 van Rheenen W, Shatunov A, Dekker AM, McLaughlin RL, Diekstra FP, Pulit SL, van der Spek RA, Võsa U, de Jong S, Robinson MR, Yang J, Fogh I, van Doormaal PT, Tazelaar GH, Koppers M, ... ... Franke L, et al. Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis. Nature Genetics. 48: 1043-8. PMID 27455348 DOI: 10.1038/ng.3622  1
2016 Li Y, Oosting M, Deelen P, Ricaño-Ponce I, Smeekens S, Jaeger M, Matzaraki V, Swertz MA, Xavier RJ, Franke L, Wijmenga C, Joosten LA, Kumar V, Netea MG. Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi. Nature Medicine. PMID 27376574 DOI: 10.1038/nm.4139  1
2016 Dekkers KF, van Iterson M, Slieker RC, Moed MH, Bonder MJ, van Galen M, Mei H, Zhernakova DV, van den Berg LH, Deelen J, van Dongen J, van Heemst D, Hofman A, Hottenga JJ, van der Kallen CJ, ... ... Franke L, et al. Blood lipids influence DNA methylation in circulating cells. Genome Biology. 17: 138. PMID 27350042 DOI: 10.1186/s13059-016-1000-6  1
2016 Gormley P, Anttila V, Winsvold BS, Palta P, Esko T, Pers TH, Farh KH, Cuenca-Leon E, Muona M, Furlotte NA, Kurth T, Ingason A, McMahon G, Ligthart L, Terwindt GM, ... ... Franke L, et al. Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nature Genetics. PMID 27322543 DOI: 10.1038/ng.3598  1
2016 Amin N, Allebrandt KV, van der Spek A, Müller-Myhsok B, Hek K, Teder-Laving M, Hayward C, Esko T, van Mill JG, Mbarek H, Watson NF, Melville SA, Del Greco FM, Byrne EM, Oole E, ... ... Franke L, et al. Genetic variants in RBFOX3 are associated with sleep latency. European Journal of Human Genetics : Ejhg. PMID 27142678 DOI: 10.1038/ejhg.2016.31  1
2016 Zhernakova A, Kurilshikov A, Bonder MJ, Tigchelaar EF, Schirmer M, Vatanen T, Mujagic Z, Vila AV, Falony G, Vieira-Silva S, Wang J, Imhann F, Brandsma E, Jankipersadsing SA, Joossens M, ... ... Franke L, et al. Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity. Science (New York, N.Y.). 352: 565-9. PMID 27126040 DOI: 10.1126/science.aad3369  1
2016 Okbay A, Baselmans BM, De Neve JE, Turley P, Nivard MG, Fontana MA, Meddens SF, Linnér RK, Rietveld CA, Derringer J, Gratten J, Lee JJ, Liu JZ, de Vlaming R, Ahluwalia TS, ... ... Franke L, et al. Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nature Genetics. PMID 27089181 DOI: 10.1038/ng.3552  1
2016 Ellinghaus D, Jostins L, Spain SL, Cortes A, Bethune J, Han B, Park YR, Raychaudhuri S, Pouget JG, Hübenthal M, Folseraas T, Wang Y, Esko T, Metspalu A, Westra HJ, ... Franke L, et al. Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. Nature Genetics. PMID 26974007 DOI: 10.1038/ng.3528  1
2016 Verweij N, Mateo Leach I, Isaacs A, Arking DE, Bis JC, Pers TH, van den Berg ME, Lyytikäinen LP, Barnett P, Wang X, Soliman EZ, van Duijn CM, Kähönen M, van Veldhuisen DJ, ... ... Franke L, et al. Twenty-eight genetic loci associated with ST-T wave amplitudes of the electrocardiogram. Human Molecular Genetics. PMID 26962151 DOI: 10.1093/hmg/ddw058  1
2016 Ricaño-Ponce I, Zhernakova DV, Deelen P, Luo O, Li X, Isaacs A, Karjalainen J, Di Tommaso J, Borek ZA, Zorro MM, Gutierrez-Achury J, Uitterlinden AG, Hofman A, van Meurs J, ... ... Franke L, et al. Refined mapping of autoimmune disease associated genetic variants with gene expression suggests an important role for non-coding RNAs. Journal of Autoimmunity. PMID 26898941 DOI: 10.1016/j.jaut.2016.01.002  1
2016 Pers TH, Timshel P, Ripke S, Lent S, Sullivan PF, O'Donovan MC, Franke L, Hirschhorn JN. Comprehensive analysis of schizophrenia-associated loci highlights ion channel pathways and biologically plausible candidate causal genes. Human Molecular Genetics. PMID 26755824 DOI: 10.1093/hmg/ddw007  1
2015 Imhann F, Bonder MJ, Vich Vila A, Fu J, Mujagic Z, Vork L, Tigchelaar EF, Jankipersadsing SA, Cenit MC, Harmsen HJ, Dijkstra G, Franke L, Xavier RJ, Jonkers D, Wijmenga C, et al. Proton pump inhibitors affect the gut microbiome. Gut. PMID 26657899 DOI: 10.1136/gutjnl-2015-310376  1
2015 Felix JF, Bradfield JP, Monnereau C, van der Valk RJ, Stergiakouli E, Chesi A, Gaillard R, Feenstra B, Thiering E, Kreiner-Møller E, Mahajan A, Pitkänen N, Joro R, Cavadino A, Huikari V, ... ... Franke L, et al. Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index. Human Molecular Genetics. PMID 26604143 DOI: 10.1093/hmg/ddv472  1
2015 Gutierrez-Achury J, Zorro MM, Ricaño-Ponce I, Zhernakova DV, Diogo D, Raychaudhuri S, Franke L, Trynka G, Wijmenga C, Zhernakova A. Functional implications of disease-specific variants in loci jointly associated to coeliac disease and rheumatoid arthritis. Human Molecular Genetics. PMID 26546613 DOI: 10.1093/hmg/ddv455  1
2015 Kogelman LJ, Zhernakova DV, Westra HJ, Cirera S, Fredholm M, Franke L, Kadarmideen HN. An integrative systems genetics approach reveals potential causal genes and pathways related to obesity. Genome Medicine. 7: 105. PMID 26482556 DOI: 10.1186/s13073-015-0229-0  1
2015 Day FR, Ruth KS, Thompson DJ, Lunetta KL, Pervjakova N, Chasman DI, Stolk L, Finucane HK, Sulem P, Bulik-Sullivan B, Esko T, Johnson AD, Elks CE, Franceschini N, He C, ... ... Franke LL, et al. Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. Nature Genetics. PMID 26414677 DOI: 10.1038/ng.3412  1
2015 Fu J, Bonder MJ, Cenit MC, Tigchelaar EF, Maatman A, Dekens JA, Brandsma E, Marczynska J, Imhann F, Weersma RK, Franke L, Poon TW, Xavier RJ, Gevers D, Hofker MH, et al. The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids. Circulation Research. 117: 817-24. PMID 26358192 DOI: 10.1161/CIRCRESAHA.115.306807  1
2015 Tigchelaar EF, Zhernakova A, Dekens JA, Hermes G, Baranska A, Mujagic Z, Swertz MA, Muñoz AM, Deelen P, Cénit MC, Franke L, Scholtens S, Stolk RP, Wijmenga C, Feskens EJ. Cohort profile: LifeLines DEEP, a prospective, general population cohort study in the northern Netherlands: study design and baseline characteristics. Bmj Open. 5: e006772. PMID 26319774 DOI: 10.1136/bmjopen-2014-006772  1
2015 Liu JZ, van Sommeren S, Huang H, Ng SC, Alberts R, Takahashi A, Ripke S, Lee JC, Jostins L, Shah T, Abedian S, Cheon JH, Cho J, Daryani NE, Franke L, et al. Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. Nature Genetics. PMID 26192919 DOI: 10.1038/ng.3359  1
2015 Shah S, Bonder MJ, Marioni RE, Zhu Z, McRae AF, Zhernakova A, Harris SE, Liewald D, Henders AK, Mendelson MM, Liu C, Joehanes R, Liang L, Levy D, ... ... Franke L, et al. Improving Phenotypic Prediction by Combining Genetic and Epigenetic Associations. American Journal of Human Genetics. 97: 75-85. PMID 26119815 DOI: 10.1016/j.ajhg.2015.05.014  1
2015 Draisma HH, Pool R, Kobl M, Jansen R, Petersen AK, Vaarhorst AA, Yet I, Haller T, Demirkan A, Esko T, Zhu G, Böhringer S, Beekman M, van Klinken JB, Römisch-Margl W, ... ... Franke L, et al. Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels. Nature Communications. 6: 7208. PMID 26068415 DOI: 10.1038/ncomms8208  1
2015 Franke L, El Bannoudi H, Jansen DT, Kok K, Trynka G, Diogo D, Swertz M, Fransen K, Knevel R, Gutierrez-Achury J, Ärlestig L, Greenberg JD, Kremer J, Pappas DA, Kanterakis A, et al. Association analysis of copy numbers of FC-gamma receptor genes for rheumatoid arthritis and other immune-mediated phenotypes. European Journal of Human Genetics : Ejhg. PMID 25966632 DOI: 10.1038/ejhg.2015.95  1
2015 Westra HJ, Arends D, Esko T, Peters MJ, Schurmann C, Schramm K, Kettunen J, Yaghootkar H, Fairfax BP, Andiappan AK, Li Y, Fu J, Karjalainen J, Platteel M, Visschedijk M, ... ... Franke L, et al. Cell Specific eQTL Analysis without Sorting Cells. Plos Genetics. 11: e1005223. PMID 25955312 DOI: 10.1371/journal.pgen.1005223  1
2015 Deelen P, Zhernakova DV, de Haan M, van der Sijde M, Bonder MJ, Karjalainen J, van der Velde KJ, Abbott KM, Fu J, Wijmenga C, Sinke RJ, Swertz MA, Franke L. Calling genotypes from public RNA-sequencing data enables identification of genetic variants that affect gene-expression levels. Genome Medicine. 7: 30. PMID 25954321 DOI: 10.1186/s13073-015-0152-4  1
2015 Chan Y, Salem RM, Hsu YH, McMahon G, Pers TH, Vedantam S, Esko T, Guo MH, Lim ET, Franke L, Smith GD, Strachan DP, Hirschhorn JN. Genome-wide Analysis of Body Proportion Classifies Height-Associated Variants by Mechanism of Action and Implicates Genes Important for Skeletal Development. American Journal of Human Genetics. 96: 695-708. PMID 25865494 DOI: 10.1016/j.ajhg.2015.02.018  1
2015 Benyamin B, Esko T, Ried JS, Radhakrishnan A, Vermeulen SH, Traglia M, Gögele M, Anderson D, Broer L, Podmore C, Luan J, Kutalik Z, Sanna S, van der Meer P, Tanaka T, ... ... Franke L, et al. Corrigendum: Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis. Nature Communications. 6: 6542. PMID 25817829 DOI: 10.1038/ncomms7542  1
2015 Wolfs MG, Gruben N, Rensen SS, Verdam FJ, Greve JW, Driessen A, Wijmenga C, Buurman WA, Franke L, Scheja L, Koonen DP, Shiri-Sverdlov R, van Haeften TW, Hofker MH, Fu J. Determining the association between adipokine expression in multiple tissues and phenotypic features of non-alcoholic fatty liver disease in obesity. Nutrition & Diabetes. 5: e146. PMID 25664838 DOI: 10.1038/nutd.2014.43  1
2015 Jin P, Andiappan AK, Quek JM, Lee B, Au B, Sio YY, Irwanto A, Schurmann C, Grabe HJ, Suri BK, Matta SA, Westra HJ, Franke L, Esko T, Sun L, et al. A functional brain-derived neurotrophic factor (BDNF) gene variant increases the risk of moderate-to-severe allergic rhinitis. The Journal of Allergy and Clinical Immunology. 135: 1486-1493.e8. PMID 25649076 DOI: 10.1016/j.jaci.2014.12.1870  1
2015 van Gerven NM, de Boer YS, Zwiers A, Verwer BJ, Drenth JP, van Hoek B, van Erpecum KJ, Beuers U, van Buuren HR, den Ouden JW, Verdonk RC, Koek GH, Brouwer JT, Guichelaar MM, Vrolijk JM, ... ... Franke L, et al. HLA-DRB1*03:01 and HLA-DRB1*04:01 modify the presentation and outcome in autoimmune hepatitis type-1. Genes and Immunity. 16: 247-52. PMID 25611558 DOI: 10.1038/gene.2014.82  1
2015 Pers TH, Karjalainen JM, Chan Y, Westra HJ, Wood AR, Yang J, Lui JC, Vedantam S, Gustafsson S, Esko T, Frayling T, Speliotes EK, Boehnke M, Raychaudhuri S, ... ... Franke L, et al. Biological interpretation of genome-wide association studies using predicted gene functions. Nature Communications. 6: 5890. PMID 25597830 DOI: 10.1038/ncomms6890  1
2015 Fehrmann RS, Karjalainen JM, Krajewska M, Westra HJ, Maloney D, Simeonov A, Pers TH, Hirschhorn JN, Jansen RC, Schultes EA, van Haagen HH, de Vries EG, te Meerman GJ, Wijmenga C, van Vugt MA, ... Franke L, et al. Gene expression analysis identifies global gene dosage sensitivity in cancer. Nature Genetics. 47: 115-25. PMID 25581432 DOI: 10.1038/ng.3173  1
2015 Kumar V, Gutierrez-Achury J, Kanduri K, Almeida R, Hrdlickova B, Zhernakova DV, Westra HJ, Karjalainen J, Ricaño-Ponce I, Li Y, Stachurska A, Tigchelaar EF, Abdulahad WH, Lähdesmäki H, Hofker MH, ... ... Franke L, et al. Systematic annotation of celiac disease loci refines pathological pathways and suggests a genetic explanation for increased interferon-gamma levels. Human Molecular Genetics. 24: 397-409. PMID 25190711 DOI: 10.1093/hmg/ddu453  1
2015 Andiappan AK, Narayanan S, Myers RA, Lee B, Nieuwenhuis MA, Nardin A, Park CS, Shin HD, Kim JH, Westra HJ, Franke L, Esko T, Metspalu A, Teo YY, Saw SM, et al. Genetic variants of inducible costimulator are associated with allergic asthma susceptibility. The Journal of Allergy and Clinical Immunology. 135: 556-8. PMID 25109803 DOI: 10.1016/j.jaci.2014.06.028  1
2015 Senapati S, Gutierrez-Achury J, Sood A, Midha V, Szperl A, Romanos J, Zhernakova A, Franke L, Alonso S, Thelma BK, Wijmenga C, Trynka G. Evaluation of European coeliac disease risk variants in a north Indian population. European Journal of Human Genetics : Ejhg. 23: 530-5. PMID 25052311 DOI: 10.1038/ejhg.2014.137  1
2015 Brandsma CA, van den Berge M, Postma DS, Jonker MR, Brouwer S, Paré PD, Sin DD, Bossé Y, Laviolette M, Karjalainen J, Fehrmann RS, Nickle DC, Hao K, Spanjer AI, Timens W, ... Franke L, et al. A large lung gene expression study identifying fibulin-5 as a novel player in tissue repair in COPD. Thorax. 70: 21-32. PMID 24990664 DOI: 10.1136/thoraxjnl-2014-205091  1
2014 Deelen P, Bonder MJ, van der Velde KJ, Westra HJ, Winder E, Hendriksen D, Franke L, Swertz MA. Genotype harmonizer: automatic strand alignment and format conversion for genotype data integration. Bmc Research Notes. 7: 901. PMID 25495213 DOI: 10.1186/1756-0500-7-901  1
2014 Pierce BL, Tong L, Chen LS, Rahaman R, Argos M, Jasmine F, Roy S, Paul-Brutus R, Westra HJ, Franke L, Esko T, Zaman R, Islam T, Rahman M, Baron JA, et al. Mediation analysis demonstrates that trans-eQTLs are often explained by cis-mediation: a genome-wide analysis among 1,800 South Asians. Plos Genetics. 10: e1004818. PMID 25474530 DOI: 10.1371/journal.pgen.1004818  1
2014 Hrdlickova B, Kumar V, Kanduri K, Zhernakova DV, Tripathi S, Karjalainen J, Lund RJ, Li Y, Ullah U, Modderman R, Abdulahad W, Lähdesmäki H, Franke L, Lahesmaa R, Wijmenga C, et al. Expression profiles of long non-coding RNAs located in autoimmune disease-associated regions reveal immune cell-type specificity. Genome Medicine. 6: 88. PMID 25419237 DOI: 10.1186/s13073-014-0088-0  1
2014 Benyamin B, Esko T, Ried JS, Radhakrishnan A, Vermeulen SH, Traglia M, Gögele M, Anderson D, Broer L, Podmore C, Luan J, Kutalik Z, Sanna S, van der Meer P, Tanaka T, ... ... Franke L, et al. Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis. Nature Communications. 5: 4926. PMID 25352340 DOI: 10.1038/ncomms5926  1
2014 Bonder MJ, Kasela S, Kals M, Tamm R, Lokk K, Barragan I, Buurman WA, Deelen P, Greve JW, Ivanov M, Rensen SS, van Vliet-Ostaptchouk JV, Wolfs MG, Fu J, Hofker MH, ... ... Franke L, et al. Genetic and epigenetic regulation of gene expression in fetal and adult human livers. Bmc Genomics. 15: 860. PMID 25282492 DOI: 10.1186/1471-2164-15-860  1
2014 Hemani G, Shakhbazov K, Westra HJ, Esko T, Henders AK, McRae AF, Yang J, Gibson G, Martin NG, Metspalu A, Franke L, Montgomery GW, Visscher PM, Powell JE. Hemani et al. reply. Nature. 514: E5-6. PMID 25279929 DOI: 10.1038/nature13692  1
2014 Kogelman LJ, Cirera S, Zhernakova DV, Fredholm M, Franke L, Kadarmideen HN. Identification of co-expression gene networks, regulatory genes and pathways for obesity based on adipose tissue RNA Sequencing in a porcine model. Bmc Medical Genomics. 7: 57. PMID 25270054 DOI: 10.1186/1755-8794-7-57  1
2014 Rietveld CA, Esko T, Davies G, Pers TH, Turley P, Benyamin B, Chabris CF, Emilsson V, Johnson AD, Lee JJ, de Leeuw C, Marioni RE, Medland SE, Miller MB, Rostapshova O, ... ... Franke L, et al. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. Proceedings of the National Academy of Sciences of the United States of America. 111: 13790-4. PMID 25201988 DOI: 10.1073/pnas.1404623111  1
2014 Kumar V, Cheng SC, Johnson MD, Smeekens SP, Wojtowicz A, Giamarellos-Bourboulis E, Karjalainen J, Franke L, Withoff S, Plantinga TS, van de Veerdonk FL, van der Meer JW, Joosten LA, Sokol H, Bauer H, et al. Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia. Nature Communications. 5: 4675. PMID 25197941 DOI: 10.1038/ncomms5675  1
2014 Geller F, Feenstra B, Carstensen L, Pers TH, van Rooij IA, Körberg IB, Choudhry S, Karjalainen JM, Schnack TH, Hollegaard MV, Feitz WF, Roeleveld N, Hougaard DM, Hirschhorn JN, Franke L, et al. Genome-wide association analyses identify variants in developmental genes associated with hypospadias. Nature Genetics. 46: 957-63. PMID 25108383 DOI: 10.1038/ng.3063  1
2014 Hoggart CJ, Venturini G, Mangino M, Gomez F, Ascari G, Zhao JH, Teumer A, Winkler TW, TÅ¡ernikova N, Luan J, Mihailov E, Ehret GB, Zhang W, Lamparter D, Esko T, ... ... Franke L, et al. Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index. Plos Genetics. 10: e1004508. PMID 25078964 DOI: 10.1371/journal.pgen.1004508  1
2014 Gockel I, Becker J, Wouters MM, Niebisch S, Gockel HR, Hess T, Ramonet D, Zimmermann J, Vigo AG, Trynka G, de León AR, de la Serna JP, Urcelay E, Kumar V, Franke L, et al. Common variants in the HLA-DQ region confer susceptibility to idiopathic achalasia. Nature Genetics. 46: 901-4. PMID 24997987 DOI: 10.1038/ng.3029  1
2014 Smolonska J, Koppelman GH, Wijmenga C, Vonk JM, Zanen P, Bruinenberg M, Curjuric I, Imboden M, Thun GA, Franke L, Probst-Hensch NM, Nürnberg P, Riemersma RA, van Schayck CP, Loth DW, et al. Common genes underlying asthma and COPD? Genome-wide analysis on the Dutch hypothesis. The European Respiratory Journal. 44: 860-72. PMID 24993907 DOI: 10.1183/09031936.00001914  1
2014 Cozen W, Timofeeva MN, Li D, Diepstra A, Hazelett D, Delahaye-Sourdeix M, Edlund CK, Franke L, Rostgaard K, Van Den Berg DJ, Cortessis VK, Smedby KE, Glaser SL, Westra HJ, Robison LL, et al. A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus. Nature Communications. 5: 3856. PMID 24920014 DOI: 10.1038/ncomms4856  1
2014 Deelen P, Menelaou A, van Leeuwen EM, Kanterakis A, van Dijk F, Medina-Gomez C, Francioli LC, Hottenga JJ, Karssen LC, Estrada K, Kreiner-Møller E, Rivadeneira F, van Setten J, Gutierrez-Achury J, Westra HJ, ... Franke L, et al. Improved imputation quality of low-frequency and rare variants in European samples using the 'Genome of The Netherlands'. European Journal of Human Genetics : Ejhg. 22: 1321-6. PMID 24896149 DOI: 10.1038/ejhg.2014.19  1
2014 Westra HJ, Franke L. From genome to function by studying eQTLs. Biochimica Et Biophysica Acta. 1842: 1896-1902. PMID 24798236 DOI: 10.1016/j.bbadis.2014.04.024  1
2014 de Boer YS, van Gerven NM, Zwiers A, Verwer BJ, van Hoek B, van Erpecum KJ, Beuers U, van Buuren HR, Drenth JP, den Ouden JW, Verdonk RC, Koek GH, Brouwer JT, Guichelaar MM, Vrolijk JM, ... ... Franke L, et al. Genome-wide association study identifies variants associated with autoimmune hepatitis type 1. Gastroenterology. 147: 443-52.e5. PMID 24768677 DOI: 10.1053/j.gastro.2014.04.022  1
2014 Li H, Chan L, Bartuzi P, Melton SD, Weber A, Ben-Shlomo S, Varol C, Raetz M, Mao X, Starokadomskyy P, van Sommeren S, Mokadem M, Schneider H, Weisberg R, Westra HJ, ... ... Franke L, et al. Copper metabolism domain-containing 1 represses genes that promote inflammation and protects mice from colitis and colitis-associated cancer. Gastroenterology. 147: 184-195.e3. PMID 24727021 DOI: 10.1053/j.gastro.2014.04.007  1
2014 Fransen K, van Sommeren S, Westra HJ, Veenstra M, Lamberts LE, Modderman R, Dijkstra G, Fu J, Wijmenga C, Franke L, Weersma RK, van Diemen CC. Correlation of genetic risk and messenger RNA expression in a Th17/IL23 pathway analysis in inflammatory bowel disease. Inflammatory Bowel Diseases. 20: 777-82. PMID 24662057 DOI: 10.1097/MIB.0000000000000013  1
2014 Hemani G, Shakhbazov K, Westra HJ, Esko T, Henders AK, McRae AF, Yang J, Gibson G, Martin NG, Metspalu A, Franke L, Montgomery GW, Visscher PM, Powell JE. Detection and replication of epistasis influencing transcription in humans. Nature. 508: 249-53. PMID 24572353 DOI: 10.1038/nature13005  1
2014 Geremek M, Ziętkiewicz E, Bruinenberg M, Franke L, Pogorzelski A, Wijmenga C, Witt M. Ciliary genes are down-regulated in bronchial tissue of primary ciliary dyskinesia patients. Plos One. 9: e88216. PMID 24516614 DOI: 10.1371/journal.pone.0088216  1
2014 Almeida R, Ricaño-Ponce I, Kumar V, Deelen P, Szperl A, Trynka G, Gutierrez-Achury J, Kanterakis A, Westra HJ, Franke L, Swertz MA, Platteel M, Bilbao JR, Barisani D, Greco L, et al. Fine mapping of the celiac disease-associated LPP locus reveals a potential functional variant. Human Molecular Genetics. 23: 2481-9. PMID 24334606 DOI: 10.1093/hmg/ddt619  1
2014 Scholtens S, Postma DS, Moffatt MF, Panasevich S, Granell R, Henderson AJ, Melén E, Nyberg F, Pershagen G, Jarvis D, Ramasamy A, Wjst M, Svanes C, Bouzigon E, Demenais F, ... ... Franke L, et al. Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure. The Journal of Allergy and Clinical Immunology. 133: 885-8. PMID 24315450 DOI: 10.1016/j.jaci.2013.08.049  1
2014 Romanos J, Rosén A, Kumar V, Trynka G, Franke L, Szperl A, Gutierrez-Achury J, van Diemen CC, Kanninga R, Jankipersadsing SA, Steck A, Eisenbarth G, van Heel DA, Cukrowska B, Bruno V, et al. Improving coeliac disease risk prediction by testing non-HLA variants additional to HLA variants. Gut. 63: 415-22. PMID 23704318 DOI: 10.1136/gutjnl-2012-304110  1
2013 Westra HJ, Peters MJ, Esko T, Yaghootkar H, Schurmann C, Kettunen J, Christiansen MW, Fairfax BP, Schramm K, Powell JE, Zhernakova A, Zhernakova DV, Veldink JH, Van den Berg LH, Karjalainen J, ... ... Franke L, et al. Systematic identification of trans eQTLs as putative drivers of known disease associations. Nature Genetics. 45: 1238-43. PMID 24013639 DOI: 10.1038/ng.2756  1
2013 Zhernakova DV, de Klerk E, Westra HJ, Mastrokolias A, Amini S, Ariyurek Y, Jansen R, Penninx BW, Hottenga JJ, Willemsen G, de Geus EJ, Boomsma DI, Veldink JH, van den Berg LH, Wijmenga C, ... ... Franke L, et al. DeepSAGE reveals genetic variants associated with alternative polyadenylation and expression of coding and non-coding transcripts. Plos Genetics. 9: e1003594. PMID 23818875 DOI: 10.1371/journal.pgen.1003594  1
2013 Rietveld CA, Medland SE, Derringer J, Yang J, Esko T, Martin NW, Westra HJ, Shakhbazov K, Abdellaoui A, Agrawal A, Albrecht E, Alizadeh BZ, Amin N, Barnard J, Baumeister SE, ... ... Franke L, et al. GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science (New York, N.Y.). 340: 1467-71. PMID 23722424 DOI: 10.1126/science.1235488  0.01
2013 Trouw LA, Daha N, Kurreeman FA, Böhringer S, Goulielmos GN, Westra HJ, Zhernakova A, Franke L, Stahl EA, Levarht EW, Stoeken-Rijsbergen G, Verduijn W, Roos A, Li Y, Houwing-Duistermaat JJ, et al. Genetic variants in the region of the C1q genes are associated with rheumatoid arthritis. Clinical and Experimental Immunology. 173: 76-83. PMID 23607884 DOI: 10.1111/cei.12097  1
2013 den Hoed M, Eijgelsheim M, Esko T, Brundel BJ, Peal DS, Evans DM, Nolte IM, Segrè AV, Holm H, Handsaker RE, Westra HJ, Johnson T, Isaacs A, Yang J, Lundby A, ... ... Franke L, et al. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nature Genetics. 45: 621-31. PMID 23583979 DOI: 10.1038/ng.2610  0.01
2013 Cvejic A, Haer-Wigman L, Stephens JC, Kostadima M, Smethurst PA, Frontini M, van den Akker E, Bertone P, Bielczyk-MaczyÅ„ska E, Farrow S, Fehrmann RS, Gray A, de Haas M, Haver VG, Jordan G, ... ... Franke L, et al. SMIM1 underlies the Vel blood group and influences red blood cell traits. Nature Genetics. 45: 542-5. PMID 23563608 DOI: 10.1038/ng.2603  1
2013 Knevel R, Krabben A, Wilson AG, Brouwer E, Leijsma MK, Lindqvist E, de Rooy DP, Daha NA, van der Linden MP, Tsonaka S, Zhernakova A, Westra HJ, Franke L, Houwing-Duistermaat JJ, Toes RE, et al. A genetic variant in granzyme B is associated with progression of joint destruction in rheumatoid arthritis. Arthritis and Rheumatism. 65: 582-9. PMID 23440692 DOI: 10.1002/art.37808  1
2013 Kumar V, Westra HJ, Karjalainen J, Zhernakova DV, Esko T, Hrdlickova B, Almeida R, Zhernakova A, Reinmaa E, Võsa U, Hofker MH, Fehrmann RS, Fu J, Withoff S, Metspalu A, ... Franke L, et al. Human disease-associated genetic variation impacts large intergenic non-coding RNA expression. Plos Genetics. 9: e1003201. PMID 23341781 DOI: 10.1371/journal.pgen.1003201  1
2012 van der Harst P, Zhang W, Mateo Leach I, Rendon A, Verweij N, Sehmi J, Paul DS, Elling U, Allayee H, Li X, Radhakrishnan A, Tan ST, Voss K, Weichenberger CX, Albers CA, ... ... Franke L, et al. Seventy-five genetic loci influencing the human red blood cell. Nature. 492: 369-75. PMID 23222517 DOI: 10.1038/nature11677  1
2012 Eyre S, Bowes J, Diogo D, Lee A, Barton A, Martin P, Zhernakova A, Stahl E, Viatte S, McAllister K, Amos CI, Padyukov L, Toes RE, Huizinga TW, Wijmenga C, ... ... Franke L, et al. High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nature Genetics. 44: 1336-40. PMID 23143596 DOI: 10.1038/ng.2462  1
2012 de Boer RA, Verweij N, van Veldhuisen DJ, Westra HJ, Bakker SJ, Gansevoort RT, Muller Kobold AC, van Gilst WH, Franke L, Mateo Leach I, van der Harst P. A genome-wide association study of circulating galectin-3. Plos One. 7: e47385. PMID 23056639 DOI: 10.1371/journal.pone.0047385  1
2012 Franceschini N, van Rooij FJ, Prins BP, Feitosa MF, Karakas M, Eckfeldt JH, Folsom AR, Kopp J, Vaez A, Andrews JS, Baumert J, Boraska V, Broer L, Hayward C, Ngwa JS, ... ... Franke L, et al. Discovery and fine mapping of serum protein loci through transethnic meta-analysis. American Journal of Human Genetics. 91: 744-53. PMID 23022100 DOI: 10.1016/j.ajhg.2012.08.021  1
2012 Fu J, Wolfs MG, Deelen P, Westra HJ, Fehrmann RS, Te Meerman GJ, Buurman WA, Rensen SS, Groen HJ, Weersma RK, van den Berg LH, Veldink J, Ophoff RA, Snieder H, van Heel D, ... ... Franke L, et al. Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression. Plos Genetics. 8: e1002431. PMID 22275870 DOI: 10.1371/journal.pgen.1002431  1
2011 Trynka G, Hunt KA, Bockett NA, Romanos J, Mistry V, Szperl A, Bakker SF, Bardella MT, Bhaw-Rosun L, Castillejo G, de la Concha EG, de Almeida RC, Dias KR, van Diemen CC, Dubois PC, ... ... Franke L, et al. Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease. Nature Genetics. 43: 1193-201. PMID 22057235 DOI: 10.1038/ng.998  1
2011 Sampietro ML, Trompet S, Verschuren JJ, Talens RP, Deelen J, Heijmans BT, de Winter RJ, Tio RA, Doevendans PA, Ganesh SK, Nabel EG, Westra HJ, Franke L, van den Akker EB, Westendorp RG, et al. A genome-wide association study identifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention. Human Molecular Genetics. 20: 4748-57. PMID 21878436 DOI: 10.1093/hmg/ddr389  1
2011 Fehrmann RS, Jansen RC, Veldink JH, Westra HJ, Arends D, Bonder MJ, Fu J, Deelen P, Groen HJ, Smolonska A, Weersma RK, Hofstra RM, Buurman WA, Rensen S, Wolfs MG, ... ... Franke L, et al. Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA. Plos Genetics. 7: e1002197. PMID 21829388 DOI: 10.1371/journal.pgen.1002197  1
2011 Dolmans GH, Werker PM, Hennies HC, Furniss D, Festen EA, Franke L, Becker K, van der Vlies P, Wolffenbuttel BH, Tinschert S, Toliat MR, Nothnagel M, Franke A, Klopp N, Wichmann HE, et al. Wnt signaling and Dupuytren's disease. The New England Journal of Medicine. 365: 307-17. PMID 21732829 DOI: 10.1056/NEJMoa1101029  1
2011 Westra HJ, Jansen RC, Fehrmann RS, te Meerman GJ, van Heel D, Wijmenga C, Franke L. MixupMapper: correcting sample mix-ups in genome-wide datasets increases power to detect small genetic effects. Bioinformatics (Oxford, England). 27: 2104-11. PMID 21653519 DOI: 10.1093/bioinformatics/btr323  1
2011 Hrdlickova B, Westra HJ, Franke L, Wijmenga C. Celiac disease: moving from genetic associations to causal variants. Clinical Genetics. 80: 203-313. PMID 21595655 DOI: 10.1111/j.1399-0004.2011.01707.x  1
2011 Janse M, Lamberts LE, Franke L, Raychaudhuri S, Ellinghaus E, Muri Boberg K, Melum E, Folseraas T, Schrumpf E, Bergquist A, Björnsson E, Fu J, Jan Westra H, Groen HJ, Fehrmann RS, et al. Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9. Hepatology (Baltimore, Md.). 53: 1977-85. PMID 21425313 DOI: 10.1002/hep.24307  1
2011 Zhernakova A, Stahl EA, Trynka G, Raychaudhuri S, Festen EA, Franke L, Westra HJ, Fehrmann RS, Kurreeman FA, Thomson B, Gupta N, Romanos J, McManus R, Ryan AW, Turner G, et al. Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. Plos Genetics. 7: e1002004. PMID 21383967 DOI: 10.1371/journal.pgen.1002004  1
2011 Knauff EA, Blauw HM, Pearson PL, Kok K, Wijmenga C, Veldink JH, van den Berg LH, Bouchard P, Fauser BC, Franke L. Copy number variants on the X chromosome in women with primary ovarian insufficiency. Fertility and Sterility. 95: 1584-8.e1. PMID 21316664 DOI: 10.1016/j.fertnstert.2011.01.018  1
2011 van Disseldorp J, Franke L, Eijkemans R, Broekmans F, Macklon N, Wijmenga C, Fauser B. Genome-wide analysis shows no genomic predictors of ovarian response to stimulation by exogenous FSH for IVF. Reproductive Biomedicine Online. 22: 382-8. PMID 21316307 DOI: 10.1016/j.rbmo.2010.12.006  1
2011 Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M, Taylor KD, Lee JC, Goyette P, Imielinski M, Latiano A, Lagacé C, Scott R, Amininejad L, Bumpstead S, Baidoo L, ... ... Franke L, et al. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nature Genetics. 43: 246-52. PMID 21297633 DOI: 10.1038/ng.764  1
2010 Wolfs MG, Rensen SS, Bruin-Van Dijk EJ, Verdam FJ, Greve JW, Sanjabi B, Bruinenberg M, Wijmenga C, van Haeften TW, Buurman WA, Franke L, Hofker MH. Co-expressed immune and metabolic genes in visceral and subcutaneous adipose tissue from severely obese individuals are associated with plasma HDL and glucose levels: a microarray study. Bmc Medical Genomics. 3: 34. PMID 20687939 DOI: 10.1186/1755-8794-3-34  1
2010 Fransen K, Visschedijk MC, van Sommeren S, Fu JY, Franke L, Festen EA, Stokkers PC, van Bodegraven AA, Crusius JB, Hommes DW, Zanen P, de Jong DJ, Wijmenga C, van Diemen CC, Weersma RK. Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease. Human Molecular Genetics. 19: 3482-8. PMID 20601676 DOI: 10.1093/hmg/ddq264  1
2010 Zhernakova A, Elbers CC, Ferwerda B, Romanos J, Trynka G, Dubois PC, de Kovel CG, Franke L, Oosting M, Barisani D, Bardella MT, Joosten LA, Saavalainen P, van Heel DA, et al. Evolutionary and functional analysis of celiac risk loci reveals SH2B3 as a protective factor against bacterial infection. American Journal of Human Genetics. 86: 970-7. PMID 20560212 DOI: 10.1016/j.ajhg.2010.05.004  1
2010 Dubois PC, Trynka G, Franke L, Hunt KA, Romanos J, Curtotti A, Zhernakova A, Heap GA, Adány R, Aromaa A, Bardella MT, van den Berg LH, Bockett NA, de la Concha EG, Dema B, et al. Multiple common variants for celiac disease influencing immune gene expression. Nature Genetics. 42: 295-302. PMID 20190752 DOI: 10.1038/ng.543  1
2010 Buizer-Voskamp JE, Franke L, Staal WG, van Daalen E, Kemner C, Ophoff RA, Vorstman JA, van Engeland H, Wijmenga C. Systematic genotype-phenotype analysis of autism susceptibility loci implicates additional symptoms to co-occur with autism. European Journal of Human Genetics : Ejhg. 18: 588-95. PMID 19935830 DOI: 10.1038/ejhg.2009.206  1
2009 Knauff EA, Franke L, van Es MA, van den Berg LH, van der Schouw YT, Laven JS, Lambalk CB, Hoek A, Goverde AJ, Christin-Maitre S, Hsueh AJ, Wijmenga C, Fauser BC. Genome-wide association study in premature ovarian failure patients suggests ADAMTS19 as a possible candidate gene. Human Reproduction (Oxford, England). 24: 2372-8. PMID 19508998 DOI: 10.1093/humrep/dep197  1
2009 van der Zwaag B, Franke L, Poot M, Hochstenbach R, Spierenburg HA, Vorstman JA, van Daalen E, de Jonge MV, Verbeek NE, Brilstra EH, van 't Slot R, Ophoff RA, van Es MA, Blauw HM, Veldink JH, et al. Gene-network analysis identifies susceptibility genes related to glycobiology in autism. Plos One. 4: e5324. PMID 19492091 DOI: 10.1371/journal.pone.0005324  1
2009 Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, et al. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. Gut. 58: 1078-83. PMID 19240061 DOI: 10.1136/gut.2008.169052  1
2009 Elbers CC, van Eijk KR, Franke L, Mulder F, van der Schouw YT, Wijmenga C, Onland-Moret NC. Using genome-wide pathway analysis to unravel the etiology of complex diseases. Genetic Epidemiology. 33: 419-31. PMID 19235186 DOI: 10.1002/gepi.20395  1
2009 Heap GA, Trynka G, Jansen RC, Bruinenberg M, Swertz MA, Dinesen LC, Hunt KA, Wijmenga C, Vanheel DA, Franke L. Complex nature of SNP genotype effects on gene expression in primary human leucocytes. Bmc Medical Genomics. 2: 1. PMID 19128478 DOI: 10.1186/1755-8794-2-1  1
2008 Franke L, de Kovel CG, Aulchenko YS, Trynka G, Zhernakova A, Hunt KA, Blauw HM, van den Berg LH, Ophoff R, Deloukas P, van Heel DA, Wijmenga C. Detection, imputation, and association analysis of small deletions and null alleles on oligonucleotide arrays. American Journal of Human Genetics. 82: 1316-33. PMID 18519066 DOI: 10.1016/j.ajhg.2008.05.008  1
2008 Hunt KA, Franke L, Deloukas P, Wijmenga C, van Heel DA. No evidence in a large UK collection for celiac disease risk variants reported by a Spanish study. Gastroenterology. 134: 1629-30; author repl. PMID 18471539 DOI: 10.1053/j.gastro.2008.03.068  1
2008 Zhernakova A, Festen EM, Franke L, Trynka G, van Diemen CC, Monsuur AJ, Bevova M, Nijmeijer RM, van 't Slot R, Heijmans R, Boezen HM, van Heel DA, van Bodegraven AA, Stokkers PC, Wijmenga C, et al. Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP. American Journal of Human Genetics. 82: 1202-10. PMID 18439550 DOI: 10.1016/j.ajhg.2008.03.016  1
2008 Hunt KA, Zhernakova A, Turner G, Heap GA, Franke L, Bruinenberg M, Romanos J, Dinesen LC, Ryan AW, Panesar D, Gwilliam R, Takeuchi F, McLaren WM, Holmes GK, Howdle PD, et al. Newly identified genetic risk variants for celiac disease related to the immune response. Nature Genetics. 40: 395-402. PMID 18311140 DOI: 10.1038/ng.102  1
2008 van Vliet-Ostaptchouk JV, Onland-Moret NC, van Haeften TW, Franke L, Elbers CC, Shiri-Sverdlov R, van der Schouw YT, Hofker MH, Wijmenga C. HHEX gene polymorphisms are associated with type 2 diabetes in the Dutch Breda cohort. European Journal of Human Genetics : Ejhg. 16: 652-6. PMID 18231124 DOI: 10.1038/sj.ejhg.5202008  1
2008 van Es MA, van Vught PW, Blauw HM, Franke L, Saris CG, Van den Bosch L, de Jong SW, de Jong V, Baas F, van't Slot R, Lemmens R, Schelhaas HJ, Birve A, Sleegers K, Van Broeckhoven C, et al. Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis. Nature Genetics. 40: 29-31. PMID 18084291 DOI: 10.1038/ng.2007.52  1
2007 Zhernakova A, Alizadeh BZ, Bevova M, van Leeuwen MA, Coenen MJ, Franke B, Franke L, Posthumus MD, van Heel DA, van der Steege G, Radstake TR, Barrera P, Roep BO, Koeleman BP, Wijmenga C. Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases. American Journal of Human Genetics. 81: 1284-8. PMID 17999365 DOI: 10.1086/522037  1
2007 van Es MA, Van Vught PW, Blauw HM, Franke L, Saris CG, Andersen PM, Van Den Bosch L, de Jong SW, van 't Slot R, Birve A, Lemmens R, de Jong V, Baas F, Schelhaas HJ, Sleegers K, et al. ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study. The Lancet. Neurology. 6: 869-77. PMID 17827064 DOI: 10.1016/S1474-4422(07)70222-3  1
2007 van Heel DA, Franke L, Hunt KA, Gwilliam R, Zhernakova A, Inouye M, Wapenaar MC, Barnardo MC, Bethel G, Holmes GK, Feighery C, Jewell D, Kelleher D, Kumar P, Travis S, et al. A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21. Nature Genetics. 39: 827-9. PMID 17558408 DOI: 10.1038/ng2058  1
2007 Diosdado B, van Bakel H, Strengman E, Franke L, van Oort E, Mulder CJ, Wijmenga C, Wapenaar MC. Neutrophil recruitment and barrier impairment in celiac disease: a genomic study. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. 5: 574-81. PMID 17336591 DOI: 10.1016/j.cgh.2006.11.014  1
2007 Elbers CC, Onland-Moret NC, Franke L, Niehoff AG, van der Schouw YT, Wijmenga C. A strategy to search for common obesity and type 2 diabetes genes. Trends in Endocrinology and Metabolism: Tem. 18: 19-26. PMID 17126559 DOI: 10.1016/j.tem.2006.11.003  1
2006 Franke L, van Bakel H, Fokkens L, de Jong ED, Egmont-Petersen M, Wijmenga C. Reconstruction of a functional human gene network, with an application for prioritizing positional candidate genes. American Journal of Human Genetics. 78: 1011-25. PMID 16685651 DOI: 10.1086/504300  1
2005 Monsuur AJ, de Bakker PI, Alizadeh BZ, Zhernakova A, Bevova MR, Strengman E, Franke L, van't Slot R, van Belzen MJ, Lavrijsen IC, Diosdado B, Daly MJ, Mulder CJ, Mearin ML, Meijer JW, et al. Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect. Nature Genetics. 37: 1341-4. PMID 16282976 DOI: 10.1038/ng1680  1
2005 Diosdado B, Stepniak DT, Monsuur AJ, Franke L, Wapenaar MC, Mearin ML, Koning F, Wijmenga C. No genetic association of the human prolyl endopeptidase gene in the Dutch celiac disease population. American Journal of Physiology. Gastrointestinal and Liver Physiology. 289: G495-500. PMID 15890709 DOI: 10.1152/ajpgi.00056.2005  1
2004 Diosdado B, Wapenaar MC, Franke L, Duran KJ, Goerres MJ, Hadithi M, Crusius JB, Meijer JW, Duggan DJ, Mulder CJ, Holstege FC, Wijmenga C. A microarray screen for novel candidate genes in coeliac disease pathogenesis. Gut. 53: 944-51. PMID 15194641  1
2004 Franke L, van Bakel H, Diosdado B, van Belzen M, Wapenaar M, Wijmenga C. TEAM: a tool for the integration of expression, and linkage and association maps. European Journal of Human Genetics : Ejhg. 12: 633-8. PMID 15114375 DOI: 10.1038/sj.ejhg.5201215  1
2003 van Tilburg JH, Sandkuijl LA, Franke L, Strengman E, Pearson PL, van Haeften TW, Wijmenga C. Genome-wide screen in obese pedigrees with type 2 diabetes mellitus from a defined Dutch population. European Journal of Clinical Investigation. 33: 1070-4. PMID 14636289  1
Show low-probability matches.