Ariel Judith Blocker, B. Sc.; PhD - Publications

Affiliations: 
1991-1995 Cell Biology European Molecular Biology Laborator (EMBL), Heidelberg, Baden-Württemberg, Germany 
 1996-2000 Bacteriology Institut Pasteur, Paris, Paris, France 
 2001-2007 Sir William Dunn School of Pathology University of Oxford, Oxford, United Kingdom 
 2008-2017 Cellulalr and Molecular Medicine University of Bristol, Bristol, England, United Kingdom 
 2017-2018 Antimicrobials, Severe Bacterial Infections Sanofi R&D 
 2018- Severe Bacterial Infections and Bacteriomics Evotec ID Lyon 
Area:
Bacteriology, anti-infectives, antibiotics

40 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Wolfson EB, Elvidge J, Tahoun A, Gillespie T, Mantell J, McAteer SP, Rossez Y, Paxton E, Lane F, Shaw DJ, Gill AC, Stevens J, Verkade P, Blocker A, Mahajan A, et al. The interaction of O157 :H7 and Typhimurium flagella with host cell membranes and cytoskeletal components. Microbiology (Reading, England). PMID 32886602 DOI: 10.1099/Mic.0.000959  0.405
2017 Bandara M, Skehel JM, Kadioglu A, Collinson I, Nobbs AH, Blocker AJ, Jenkinson HF. The accessory Sec system (SecY2A2) in Streptococcus pneumoniae is involved in export of pneumolysin toxin, adhesion and biofilm formation. Microbes and Infection. PMID 28456649 DOI: 10.1016/J.Micinf.2017.04.003  0.436
2017 Mattock E, Blocker AJ. How Do the Virulence Factors of Work Together to Cause Disease? Frontiers in Cellular and Infection Microbiology. 7: 64. PMID 28393050 DOI: 10.3389/Fcimb.2017.00064  0.328
2016 Roehrich AD, Bordignon E, Mode S, Shen DK, Liu X, Pain M, Murillo I, Martinez-Argudo I, Sessions RB, Blocker AJ. Steps for Shigella Gatekeeper MxiC Function in Hierarchical Type III Secretion Regulation. The Journal of Biological Chemistry. PMID 27974466 DOI: 10.1074/Jbc.M116.746826  0.483
2016 Makino F, Shen D, Kajimura N, Kawamoto A, Pissaridou P, Oswin H, Pain M, Murillo I, Namba K, Blocker AJ. The Architecture of the Cytoplasmic Region of Type III Secretion Systems. Scientific Reports. 6: 33341. PMID 27686865 DOI: 10.1038/Srep33341  0.493
2016 Bandara M, Corey RA, Martin R, Skehel JM, Blocker AJ, Jenkinson HF, Collinson I. Composition and activity of the non-canonical Gram-positive SecY2 complex. The Journal of Biological Chemistry. PMID 27551046 DOI: 10.1074/Jbc.M116.729806  0.43
2016 Murillo I, Martinez-Argudo I, Blocker AJ. Genetic Dissection of the Signaling Cascade that Controls Activation of the Shigella Type III Secretion System from the Needle Tip Scientific Reports. 6: 27649-27649. PMID 27277624 DOI: 10.1038/Srep27649  0.483
2016 Shen DK, Blocker AJ. MxiA, MxiC and IpaD Regulate Substrate Selection and Secretion Mode in the T3SS of Shigella flexneri. Plos One. 11: e0155141. PMID 27171191 DOI: 10.1371/Journal.Pone.0155141  0.469
2015 Verasdonck J, Shen DK, Treadgold A, Arthur C, Böckmann A, Meier BH, Blocker AJ. Reassessment of MxiH subunit orientation and fold within native Shigella T3SS needles using surface labelling and solid-state NMR. Journal of Structural Biology. PMID 26439285 DOI: 10.1016/J.Jsb.2015.10.005  0.301
2015 Perdu C, Huber P, Bouillot S, Blocker A, Elsen S, Attrée I, Faudry E. ExsB is required for correct assembly of the Pseudomonas aeruginosa type III secretion apparatus in the bacterial membrane and full virulence in vivo. Infection and Immunity. 83: 1789-98. PMID 25690097 DOI: 10.1128/Iai.00048-15  0.424
2015 Cheung M, Shen DK, Makino F, Kato T, Roehrich AD, Martinez-Argudo I, Walker ML, Murillo I, Liu X, Pain M, Brown J, Frazer G, Mantell J, Mina P, Todd T, ... ... Blocker AJ, et al. Three-dimensional electron microscopy reconstruction and cysteine-mediated crosslinking provide a model of the type III secretion system needle tip complex. Molecular Microbiology. 95: 31-50. PMID 25353930 DOI: 10.1111/Mmi.12843  0.464
2014 Kajimura N, Makino F, Cheung MP, Kato T, Blocker AJ, Namba K. 2P019 Structural analysis of needle complex from shigella flexneri by cryo electron microscopy(01A. Protein: Structure,Poster,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014)) Seibutsu Butsuri. 54. DOI: 10.2142/Biophys.54.S198_1  0.304
2013 Roehrich AD, Guillossou E, Blocker AJ, Martinez-Argudo I. Shigella IpaD has a dual role: signal transduction from the type III secretion system needle tip and intracellular secretion regulation. Molecular Microbiology. 87: 690-706. PMID 23305090 DOI: 10.1111/Mmi.12124  0.496
2013 Martinez-Argudo I, Veenendaal AKJ, Liu X, Roehrich AD, Ronessen MC, Franzoni G, Rietschoten KNv, Morimoto YV, Saijo-Hamano Y, Avison MB, Studholme DJ, Namba K, Minamino T, Blocker AJ. Isolation of Salmonella Mutants Resistant to the Inhibitory Effect of Salicylidene acylhydrazides on Flagella-Mediated Motility Plos One. 8. PMID 23300965 DOI: 10.1371/Journal.Pone.0052179  0.348
2013 Kajimura N, Cheung MP, Kato T, Blocker AJ, Namba K. 1P083 Structural analysis of needle complex from shigella flexineri by cryo electron microscopy(01E. Protein:Measurement & Analysis,Poster) Seibutsu Butsuri. 53. DOI: 10.2142/Biophys.53.S119_5  0.305
2012 Shen DK, Moriya N, Martinez-Argudo I, Blocker AJ. Needle length control and the secretion substrate specificity switch are only loosely coupled in the type III secretion apparatus of Shigella. Microbiology (Reading, England). 158: 1884-1896. PMID 22575894 DOI: 10.1099/Mic.0.059618-0  0.485
2012 Fujii T, Cheung M, Blanco A, Kato T, Blocker AJ, Namba K. Structure of a type III secretion needle at 7-Å resolution provides insights into its assembly and signaling mechanisms. Proceedings of the National Academy of Sciences of the United States of America. 109: 4461-6. PMID 22388746 DOI: 10.1073/Pnas.1116126109  0.474
2011 McDowell MA, Johnson S, Deane JE, Cheung M, Roehrich AD, Blocker AJ, McDonnell JM, Lea SM. Structural and functional studies on the N-terminal domain of the Shigella type III secretion protein MxiG. The Journal of Biological Chemistry. 286: 30606-14. PMID 21733840 DOI: 10.1074/Jbc.M111.243865  0.361
2010 Martinez-Argudo I, Blocker AJ. The Shigella T3SS needle transmits a signal for MxiC release, which controls secretion of effectors. Molecular Microbiology. 78: 1365-78. PMID 21143311 DOI: 10.1111/J.1365-2958.2010.07413.X  0.478
2010 Shen DK, Saurya S, Wagner C, Nishioka H, Blocker AJ. Domains of the Shigella flexneri type III secretion system IpaB protein involved in secretion regulation. Infection and Immunity. 78: 4999-5010. PMID 20937761 DOI: 10.1128/Iai.00470-10  0.44
2010 Roehrich AD, Martinez-Argudo I, Johnson S, Blocker AJ, Veenendaal AK. The extreme C terminus of Shigella flexneri IpaB is required for regulation of type III secretion, needle tip composition, and binding. Infection and Immunity. 78: 1682-91. PMID 20086081 DOI: 10.1128/Iai.00645-09  0.519
2009 Hodgkinson JL, Horsley A, Stabat D, Simon M, Johnson S, da Fonseca PC, Morris EP, Wall JS, Lea SM, Blocker AJ. Three-dimensional reconstruction of the Shigella T3SS transmembrane regions reveals 12-fold symmetry and novel features throughout. Nature Structural & Molecular Biology. 16: 477-85. PMID 19396171 DOI: 10.1038/nsmb.1599  0.344
2009 Veenendaal AK, Sundin C, Blocker AJ. Small-molecule type III secretion system inhibitors block assembly of the Shigella type III secreton. Journal of Bacteriology. 191: 563-70. PMID 18996990 DOI: 10.1128/JB.01004-08  0.344
2008 Blocker AJ, Deane JE, Veenendaal AK, Roversi P, Hodgkinson JL, Johnson S, Lea SM. What's the point of the type III secretion system needle? Proceedings of the National Academy of Sciences of the United States of America. 105: 6507-13. PMID 18458349 DOI: 10.1073/Pnas.0708344105  0.39
2007 Zenk SF, Stabat D, Hodgkinson JL, Veenendaal AKJ, Johnson S, Blocker AJ. Identification of minor inner-membrane components of the Shigella type III secretion system 'needle complex'. Microbiology (Reading, England). 153: 2405-2415. PMID 17660405 DOI: 10.1099/mic.0.2007/007781-0  0.359
2007 Veenendaal AK, Hodgkinson JL, Schwarzer L, Stabat D, Zenk SF, Blocker AJ. The type III secretion system needle tip complex mediates host cell sensing and translocon insertion. Molecular Microbiology. 63: 1719-30. PMID 17367391 DOI: 10.1111/J.1365-2958.2007.05620.X  0.497
2007 Johnson S, Roversi P, Espina M, Olive A, Deane JE, Birket S, Field T, Picking WD, Blocker AJ, Galyov EE, Picking WL, Lea SM. Self-chaperoning of the type III secretion system needle tip proteins IpaD and BipD. The Journal of Biological Chemistry. 282: 4035-44. PMID 17077085 DOI: 10.1074/Jbc.M607945200  0.443
2006 Deane JE, Roversi P, Cordes FS, Johnson S, Kenjale R, Daniell S, Booy F, Picking WD, Picking WL, Blocker AJ, Lea SM. Molecular model of a type III secretion system needle: Implications for host-cell sensing. Proceedings of the National Academy of Sciences of the United States of America. 103: 12529-33. PMID 16888041 DOI: 10.1073/Pnas.0602689103  0.502
2005 Cordes FS, Daniell S, Kenjale R, Saurya S, Picking WL, Picking WD, Booy F, Lea SM, Blocker A. Helical packing of needles from functionally altered Shigella type III secretion systems. Journal of Molecular Biology. 354: 206-11. PMID 16243352 DOI: 10.1016/J.Jmb.2005.09.062  0.38
2005 Kenjale R, Wilson J, Zenk SF, Saurya S, Picking WL, Picking WD, Blocker A. The needle component of the type III secreton of Shigella regulates the activity of the secretion apparatus. The Journal of Biological Chemistry. 280: 42929-37. PMID 16227202 DOI: 10.1074/Jbc.M508377200  0.503
2005 Picking WL, Nishioka H, Hearn PD, Baxter MA, Harrington AT, Blocker A, Picking WD. IpaD of Shigella flexneri is independently required for regulation of Ipa protein secretion and efficient insertion of IpaB and IpaC into host membranes. Infection and Immunity. 73: 1432-40. PMID 15731041 DOI: 10.1128/Iai.73.3.1432-1440.2005  0.376
2003 Cordes FS, Komoriya K, Larquet E, Yang S, Egelman EH, Blocker A, Lea SM. Helical structure of the needle of the type III secretion system of Shigella flexneri. The Journal of Biological Chemistry. 278: 17103-7. PMID 12571230 DOI: 10.1074/Jbc.M300091200  0.328
2002 Magdalena J, Hachani A, Chamekh M, Jouihri N, Gounon P, Blocker A, Allaoui A. Spa32 regulates a switch in substrate specificity of the type III secreton of Shigella flexneri from needle components to Ipa proteins. Journal of Bacteriology. 184: 3433-41. PMID 12057936 DOI: 10.1128/jb.184.13.3433-3441.2002  0.353
2001 Al-Haddad A, Shonn MA, Redlich B, Blocker A, Burkhardt JK, Yu H, Hammer JA, Weiss DG, Steffen W, Griffiths G, Kuznetsov SA. Myosin Va bound to phagosomes binds to F-actin and delays microtubule-dependent motility. Molecular Biology of the Cell. 12: 2742-55. PMID 11553713 DOI: 10.1091/Mbc.12.9.2742  0.571
2001 Blocker A, Jouihri N, Larquet E, Gounon P, Ebel F, Parsot C, Sansonetti P, Allaoui A. Structure and composition of the Shigella flexneri "needle complex", a part of its type III secreton. Molecular Microbiology. 39: 652-663. PMID 11169106 DOI: 10.1046/J.1365-2958.2001.02200.X  0.525
2000 Nhieu GTV, Bourdet‐Sicard R, Duménil G, Blocker A, Sansonetti PJ. Bacterial signals and cell responses during Shigella entry into epithelial cells. Cellular Microbiology. 2: 187-193. PMID 11207575 DOI: 10.1046/J.1462-5822.2000.00046.X  0.541
1999 Blocker A, Gounon P, Larquet E, Niebuhr K, Cabiaux V, Parsot C, Sansonetti P. The tripartite type III secreton of Shigella flexneri inserts IpaB and IpaC into host membranes. The Journal of Cell Biology. 147: 683-93. PMID 10545510 DOI: 10.1083/Jcb.147.3.683  0.555
1998 Blocker A, Parsot C, Sansonetti P. Shigella IPA proteins: Biochemistry and interactions with host cells Biology of the Cell. 90: 114-114. DOI: 10.1016/S0248-4900(98)80271-2  0.48
1997 Blocker A, Severin FF, Burkhardt JK, Bingham JB, Yu H, Olivo JC, Schroer TA, Hyman AA, Griffiths G. Molecular requirements for bi-directional movement of phagosomes along microtubules. The Journal of Cell Biology. 137: 113-29. PMID 9105041 DOI: 10.1083/Jcb.137.1.113  0.562
1996 Blocker A, Severin FF, Habermann A, Hyman AA, Griffiths G, Burkhardt JK. Microtubule-associated protein-dependent binding of phagosomes to microtubules Journal of Biological Chemistry. 271: 3803-3811. PMID 8631997 DOI: 10.1074/Jbc.271.7.3803  0.383
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