| Year |
Citation |
Score |
| 2023 |
Hill W, Lim EL, Weeden CE, Lee C, Augustine M, Chen K, Kuan FC, Marongiu F, Evans EJ, Moore DA, Rodrigues FS, Pich O, Bakker B, Cha H, Myers R, ... ... Downward J, et al. Lung adenocarcinoma promotion by air pollutants. Nature. 616: 159-167. PMID 37020004 DOI: 10.1038/s41586-023-05874-3 |
0.441 |
|
| 2020 |
Zecchin D, Moore C, Michailidis F, Horswell S, Rana S, Howell M, Downward J. Combined targeting of G protein-coupled receptor and EGF receptor signaling overcomes resistance to PI3K pathway inhibitors in PTEN-null triple negative breast cancer. Embo Molecular Medicine. e11987. PMID 32672423 DOI: 10.15252/Emmm.202011987 |
0.434 |
|
| 2020 |
Rodríguez-Martínez M, Boissiére T, Gonzalez MN, Litchfield K, Mitter R, Walker J, Kjœr S, Ismail M, Downward J, Swanton C, Svejstrup JQ. Evidence That STK19 Is Not an NRAS-dependent Melanoma Driver. Cell. 181: 1395-1405.e11. PMID 32531245 DOI: 10.1016/J.Cell.2020.04.014 |
0.342 |
|
| 2020 |
Wamaitha SE, Grybel KJ, Alanis-Lobato G, Gerri C, Ogushi S, McCarthy A, Mahadevaiah SK, Healy L, Lea RA, Molina-Arcas M, Devito LG, Elder K, Snell P, Christie L, Downward J, et al. IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche. Nature Communications. 11: 764. PMID 32034154 DOI: 10.1038/S41467-020-14629-X |
0.329 |
|
| 2020 |
Carné Sd, East P, Moore C, Downward J. Abstract B11: RAS orchestrates the increase of interstitial adenosine in lung adenocarcinoma to promote immune evasion Cancer Immunology Research. 8. DOI: 10.1158/2326-6074.Tumimm18-B11 |
0.387 |
|
| 2020 |
Jones GG, Rio IBD, Sari S, Sekerim A, Young LC, Hartig N, El-Bahrawy MA, Molina-Arcas M, Downward J, Rodriguez-Viciana P. Abstract B26: The SHOC2 phosphatase complex as a therapeutic target for ERK-pathway inhibition in RAS-driven tumors Molecular Cancer Research. 18. DOI: 10.1158/1557-3125.Ras18-B26 |
0.44 |
|
| 2020 |
Baer R, Rosewell I, Hancock D, Molina-Arcas M, Downward J. Abstract B19: New tools to study the role of RAS/CRAF interaction in RAS-driven lung cancer Molecular Cancer Research. 18. DOI: 10.1158/1557-3125.Ras18-B19 |
0.442 |
|
| 2019 |
Molina-Arcas M, Moore C, Rana S, van Maldegem F, Mugarza E, Romero-Clavijo P, Herbert E, Horswell S, Li LS, Janes MR, Hancock DC, Downward J. Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer. Science Translational Medicine. 11. PMID 31534020 DOI: 10.1126/Scitranslmed.Aaw7999 |
0.412 |
|
| 2019 |
Lionarons DA, Hancock DC, Rana S, East P, Moore C, Murillo MM, Carvalho J, Spencer-Dene B, Herbert E, Stamp G, Damry D, Calado DP, Rosewell I, Fritsch R, Neubig RR, ... ... Downward J, et al. RAC1 Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance. Cancer Cell. PMID 31257073 DOI: 10.1016/J.Ccell.2019.05.015 |
0.342 |
|
| 2019 |
Liu H, Ertay A, Peng P, Li J, Liu D, Xiong H, Zou Y, Qiu H, Hancock D, Yuan X, Huang WC, Ewing RM, Downward J, Wang Y. SGLT1 is required for the survival of triple negative breast cancer cells via potentiation of EGFR activity. Molecular Oncology. PMID 31199048 DOI: 10.1002/1878-0261.12530 |
0.373 |
|
| 2019 |
Jones GG, Del Río IB, Sari S, Sekerim A, Young LC, Hartig N, Areso Zubiaur I, El-Bahrawy MA, Hynds RE, Lei W, Molina-Arcas M, Downward J, Rodriguez-Viciana P. SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers. Nature Communications. 10: 2532. PMID 31182717 DOI: 10.1038/S41467-019-10367-X |
0.454 |
|
| 2019 |
Wang Y, Xiong H, Liu D, Hill C, Ertay A, Li J, Zou Y, Miller P, White E, Downward J, Goldin RD, Yuan X, Lu X. Autophagy inhibition specifically promotes epithelial-mesenchymal transition and invasion in RAS-mutated cancer cells. Autophagy. 1-14. PMID 30782064 DOI: 10.1080/15548627.2019.1569912 |
0.467 |
|
| 2019 |
Mugarza E, Maldegem Fv, Sopena ML, Arcas MM, Downward J. Abstract A145: Study of mechanisms of immune evasion of oncogenic KRAS in NSCLC Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-A145 |
0.324 |
|
| 2019 |
Molina-Arcas M, Moore C, Rana S, Maldegem FV, Mugarza E, Romero-Clavijo P, Horswell S, Hancock D, Downward J. Abstract B073: Development of combination therapies to potentiate the impact of KRAS-G12C inhibitors in lung cancer Molecular Cancer Therapeutics. 18. DOI: 10.1158/1535-7163.Targ-19-B073 |
0.416 |
|
| 2018 |
Murillo MM, Rana S, Spencer-Dene B, Nye E, Stamp G, Downward J. Disruption of the Interaction of RAS with PI 3-Kinase Induces Regression of EGFR-Mutant-Driven Lung Cancer. Cell Reports. 25: 3545-3553.e2. PMID 30590030 DOI: 10.1016/J.Celrep.2018.12.003 |
0.458 |
|
| 2018 |
Tsolakos N, Durrant TN, Chessa T, Suire SM, Oxley D, Kulkarni S, Downward J, Perisic O, Williams RL, Stephens L, Hawkins PT. Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors. Proceedings of the National Academy of Sciences of the United States of America. PMID 30442661 DOI: 10.1073/Pnas.1803446115 |
0.363 |
|
| 2018 |
Yao L, Conforti F, Hill C, Bell J, Drawater L, Li J, Liu D, Xiong H, Alzetani A, Chee SJ, Marshall BG, Fletcher SV, Hancock D, Coldwell M, Yuan X, ... ... Downward J, et al. Paracrine signalling during ZEB1-mediated epithelial-mesenchymal transition augments local myofibroblast differentiation in lung fibrosis. Cell Death and Differentiation. PMID 30050057 DOI: 10.1038/S41418-018-0175-7 |
0.358 |
|
| 2018 |
Soutar MPM, Kempthorne L, Miyakawa S, Annuario E, Melandri D, Harley J, O'Sullivan GA, Wray S, Hancock DC, Cookson MR, Downward J, Carlton M, Plun-Favreau H. AKT signalling selectively regulates PINK1 mitophagy in SHSY5Y cells and human iPSC-derived neurons. Scientific Reports. 8: 8855. PMID 29891871 DOI: 10.1038/S41598-018-26949-6 |
0.37 |
|
| 2018 |
Miess H, Dankworth B, Gouw AM, Rosenfeldt M, Schmitz W, Jiang M, Saunders B, Howell M, Downward J, Felsher DW, Peck B, Schulze A. The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma. Oncogene. PMID 29872221 DOI: 10.1038/S41388-018-0315-Z |
0.323 |
|
| 2018 |
Molina-Arcas M, Moore C, Rana S, Maldegem Fv, Horswell S, Hancock D, Downward J. Abstract 2987: Identification of new combination therapies for lung tumors harboring KRAS mutations Cancer Research. 78: 2987-2987. DOI: 10.1158/1538-7445.Am2018-2987 |
0.414 |
|
| 2018 |
Ismail MS, Downward J. Abstract LB-A17: Identification and Characterization of Cyclic Peptide Inhibitors for Ras/PI3K and Ras/Raf Protein Complexes Molecular Cancer Therapeutics. 17. DOI: 10.1158/1535-7163.Targ-17-Lb-A17 |
0.406 |
|
| 2018 |
Li H, Stokes WB, Chater E, Rupniewska E, Roy R, Mauri FA, Liu X, Kaliszczak M, Downward J, Aboagye E, Tang H, Wang Y, Seckl MJ, Pardo OE. Resistance to tyrosine kinase-targeted therapy in lung cancer: Autophagy and metabolic changes Meta Gene. 17: S10. DOI: 10.1016/J.Mgene.2018.05.044 |
0.396 |
|
| 2017 |
Coelho MA, de Carné Trécesson S, Rana S, Zecchin D, Moore C, Molina-Arcas M, East P, Spencer-Dene B, Nye E, Barnouin K, Snijders AP, Lai WS, Blackshear PJ, Downward J. Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA. Immunity. PMID 29246442 DOI: 10.1016/J.Immuni.2017.11.016 |
0.322 |
|
| 2017 |
Mancini M, Gal H, Gaborit N, Mazzeo L, Romaniello D, Salame TM, Lindzen M, Mahlknecht G, Enuka Y, Burton DG, Roth L, Noronha A, Marrocco I, Adreka D, Altstadter RE, ... ... Downward J, et al. An oligoclonal antibody durably overcomes resistance of lung cancer to third-generation EGFR inhibitors. Embo Molecular Medicine. PMID 29212784 DOI: 10.15252/Emmm.201708076 |
0.561 |
|
| 2016 |
Mathew G, Hannan A, Hertzler-Schaefer K, Wang F, Feng GS, Zhong J, Zhao JJ, Downward J, Zhang X. Targeting of Ras-mediated FGF signaling suppresses Pten-deficient skin tumor. Proceedings of the National Academy of Sciences of the United States of America. PMID 27799550 DOI: 10.1073/Pnas.1604450113 |
0.443 |
|
| 2016 |
Li H, Stokes W, Chater E, Roy R, de Bruin E, Hu Y, Liu Z, Smit EF, Heynen GJ, Downward J, Seckl MJ, Wang Y, Tang H, Pardo OE. Decreased glutathione biosynthesis contributes to EGFR T790M-driven erlotinib resistance in non-small cell lung cancer. Cell Discovery. 2: 16031. PMID 27721983 DOI: 10.1038/Celldisc.2016.31 |
0.342 |
|
| 2016 |
Houslay DM, Anderson KE, Chessa T, Kulkarni S, Fritsch R, Downward J, Backer JM, Stephens LR, Hawkins PT. Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells. Science Signaling. 9: ra82. PMID 27531651 DOI: 10.1126/Scisignal.Aae0453 |
0.408 |
|
| 2016 |
Castellano E, Molina-Arcas M, Krygowska AA, East P, Warne P, Nicol A, Downward J. RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression. Nature Communications. 7: 11245. PMID 27071537 DOI: 10.1038/Ncomms11245 |
0.477 |
|
| 2016 |
Pardo OE, Arcaro A, Salerno G, Raguz S, Downward J, Seckl MJ. Fibroblast growth factor-2 induces translational regulation of Bcl-XL and Bcl-2 via a MEK-dependent pathway. Correlation with resistance to etoposide-induced apoptosis. The Journal of Biological Chemistry. 290: 15390. PMID 26092981 DOI: 10.1074/Jbc.A115.109006 |
0.452 |
|
| 2016 |
Pender A, Rana S, Garcia-Murillas I, Cutts R, Gonzalez D, O'Brien M, Bhosle J, Turner NC, Popat S, Downward J. Simultaneous EGFR mutation detection and copy number assessment in circulating tumour DNA (ctDNA) to inform molecular methods of therapy resistance and plasma ctDNA content in lung adenocarcinoma. Journal of Clinical Oncology. 34. DOI: 10.1200/Jco.2016.34.15_Suppl.E23027 |
0.314 |
|
| 2015 |
Godin-Heymann N, Brabetz S, Murillo MM, Saponaro M, Santos CR, Lobley A, East P, Chakravarty P, Matthews N, Kelly G, Jordan S, Castellano E, Downward J. Tumour-suppression function of KLF12 through regulation of anoikis. Oncogene. PMID 26455320 DOI: 10.1038/Onc.2015.394 |
0.37 |
|
| 2015 |
Mancini M, Gaborit N, Lindzen M, Salame TM, Dall'Ora M, Sevilla-Sharon M, Abdul-Hai A, Downward J, Yarden Y. Combining three antibodies nullifies feedback-mediated resistance to erlotinib in lung cancer. Science Signaling. 8: ra53. PMID 26038598 DOI: 10.1126/Scisignal.Aaa0725 |
0.587 |
|
| 2015 |
Downward J. RAS Synthetic Lethal Screens Revisited: Still Seeking the Elusive Prize? Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 1802-9. PMID 25878361 DOI: 10.1158/1078-0432.Ccr-14-2180 |
0.412 |
|
| 2015 |
Smith D, Armenteros E, Percy L, Kumar M, Lach A, Herledan G, Stubbs M, Downward J, Yong K. RAS mutation status and bortezomib therapy for relapsed multiple myeloma. British Journal of Haematology. 169: 905-8. PMID 25580780 DOI: 10.1111/Bjh.13258 |
0.312 |
|
| 2014 |
Wang Y, Bu F, Royer C, Serres S, Larkin JR, Soto MS, Sibson NR, Salter V, Fritzsche F, Turnquist C, Koch S, Zak J, Zhong S, Wu G, Liang A, ... ... Downward J, et al. ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1. Nature Cell Biology. 16: 1092-104. PMID 25344754 DOI: 10.1038/Ncb3050 |
0.323 |
|
| 2014 |
Murillo MM, Zelenay S, Nye E, Castellano E, Lassailly F, Stamp G, Downward J. RAS interaction with PI3K p110α is required for tumor-induced angiogenesis. The Journal of Clinical Investigation. 124: 3601-11. PMID 25003191 DOI: 10.1172/Jci74134 |
0.34 |
|
| 2014 |
Endesfelder D, Burrell RA, Kanu N, McGranahan N, Howell M, Parker PJ, Downward J, Swanton C, Kschischo M. Chromosomal instability selects gene copy-number variants encoding core regulators of proliferation in ER+ breast cancer. Cancer Research. 74: 4853-63. PMID 24970479 DOI: 10.1158/0008-5472.Can-13-2664 |
0.308 |
|
| 2014 |
de Bruin EC, Cowell C, Warne PH, Jiang M, Saunders RE, Melnick MA, Gettinger S, Walther Z, Wurtz A, Heynen GJ, Heideman DA, Gómez-Román J, García-Castaño A, Gong Y, Ladanyi M, ... ... Downward J, et al. Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer. Cancer Discovery. 4: 606-19. PMID 24535670 DOI: 10.1158/2159-8290.Cd-13-0741 |
0.399 |
|
| 2014 |
Downward J. RAS's cloak of invincibility slips at last? Cancer Cell. 25: 5-6. PMID 24434204 DOI: 10.1016/J.Ccr.2013.12.016 |
0.371 |
|
| 2014 |
Kumar MS, Armenteros-Monterroso E, East P, Chakravorty P, Matthews N, Winslow MM, Downward J. HMGA2 functions as a competing endogenous RNA to promote lung cancer progression. Nature. 505: 212-7. PMID 24305048 DOI: 10.1038/Nature12785 |
0.331 |
|
| 2014 |
Linch M, Sanz-Garcia M, Rosse C, Riou P, Peel N, Madsen CD, Sahai E, Downward J, Khwaja A, Dillon C, Roffey J, Cameron AJ, Parker PJ. Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids. Carcinogenesis. 35: 396-406. PMID 24072773 DOI: 10.1093/Carcin/Bgt313 |
0.408 |
|
| 2013 |
Sheridan C, Downward J. Inhibiting the RAS-PI3K Pathway in Cancer Therapy Enzymes. 34: 107-136. PMID 25034102 DOI: 10.1016/B978-0-12-420146-0.00005-6 |
0.451 |
|
| 2013 |
Castellano E, Sheridan C, Thin MZ, Nye E, Spencer-Dene B, Diefenbacher ME, Moore C, Kumar MS, Murillo MM, Grönroos E, Lassailly F, Stamp G, Downward J. Requirement for Interaction of PI3-Kinase p110α with RAS in Lung Tumor Maintenance Cancer Cell. 24: 617-630. PMID 24229709 DOI: 10.1016/J.Ccr.2013.09.012 |
0.414 |
|
| 2013 |
Fritsch R, de Krijger I, Fritsch K, George R, Reason B, Kumar MS, Diefenbacher M, Stamp G, Downward J. RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms. Cell. 153: 1050-63. PMID 23706742 DOI: 10.1016/J.Cell.2013.04.031 |
0.473 |
|
| 2013 |
Weigelt B, Warne PH, Lambros MB, Reis-Filho JS, Downward J. PI3K pathway dependencies in endometrioid endometrial cancer cell lines. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 3533-44. PMID 23674493 DOI: 10.1158/1078-0432.Ccr-12-3815 |
0.416 |
|
| 2013 |
Molina-Arcas M, Hancock DC, Sheridan C, Kumar MS, Downward J. Coordinate direct input of both KRAS and IGF1 receptor to activation of PI3 kinase in KRAS -mutant lung cancer Cancer Discovery. 3: 548-563. PMID 23454899 DOI: 10.1158/2159-8290.Cd-12-0446 |
0.461 |
|
| 2013 |
Sheridan C, Castellano E, Thin MZ, Murillo M, Lassailly F, Stamp G, Downward J. Abstract A54: Requirement for interaction of PI 3-kinase p110alpha with Ras in lung tumor maintenance Cancer Research. 73. DOI: 10.1158/1538-7445.Fbcr13-A54 |
0.428 |
|
| 2013 |
Downward J. Abstract SY25-02: Synthetic lethal approaches to targeting RAS mutant tumors: Is there an Achilles' heel. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Sy25-02 |
0.454 |
|
| 2013 |
Weigelt B, Warne PH, Lambros MB, Reis-Filho JS, Downward J. Abstract 4472: PI3K pathway dependencies in endometrioid endometrial cancer. Cancer Research. 73: 4472-4472. DOI: 10.1158/1538-7445.Am2013-4472 |
0.428 |
|
| 2013 |
Downward J. Abstract PL04-04: Synthetic lethal approaches to targeting Ras mutant cancers. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-Pl04-04 |
0.465 |
|
| 2013 |
Kumar MS, Armenteros-Monterroso E, East P, Chakravorty P, Matthews N, Winslow MM, Downward J. Abstract B221: Hmga2 furthers lung adenocarcinoma progression through function as a competing endogenous RNA. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-B221 |
0.339 |
|
| 2013 |
Kumar MS, Downward J. Abstract PR14: Targeting the GATA2 transcriptional network in K-Ras driven lung adenocarcinoma Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Pms-Pr14 |
0.37 |
|
| 2012 |
Weigelt B, Downward J. Genomic Determinants of PI3K Pathway Inhibitor Response in Cancer. Frontiers in Oncology. 2: 109. PMID 22970424 DOI: 10.3389/Fonc.2012.00109 |
0.378 |
|
| 2012 |
Bögel G, Gujdár A, Geiszt M, Lányi Ã, Fekete A, Sipeki S, Downward J, Buday L. Frank-ter Haar syndrome protein Tks4 regulates epidermal growth factor-dependent cell migration. The Journal of Biological Chemistry. 287: 31321-9. PMID 22829589 DOI: 10.1074/Jbc.M111.324897 |
0.453 |
|
| 2012 |
Steckel M, Molina-Arcas M, Weigelt B, Marani M, Warne PH, Kuznetsov H, Kelly G, Saunders B, Howell M, Downward J, Hancock DC. Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies. Cell Research. 22: 1227-45. PMID 22613949 DOI: 10.1038/Cr.2012.82 |
0.392 |
|
| 2012 |
Kumar MS, Hancock DC, Molina-Arcas M, Steckel M, East P, Diefenbacher M, Armenteros-Monterroso E, Lassailly F, Matthews N, Nye E, Stamp G, Behrens A, Downward J. The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer. Cell. 149: 642-55. PMID 22541434 DOI: 10.1016/J.Cell.2012.02.059 |
0.454 |
|
| 2012 |
Molina-Arcas M, Downward J. How to fool a wonder drug: truncate and dimerize. Cancer Cell. 21: 7-9. PMID 22264784 DOI: 10.1016/J.Ccr.2011.12.017 |
0.331 |
|
| 2012 |
Schulze A, Downward J. Flicking the Warburg switch-tyrosine phosphorylation of pyruvate dehydrogenase kinase regulates mitochondrial activity in cancer cells. Molecular Cell. 44: 846-8. PMID 22195959 DOI: 10.1016/J.Molcel.2011.12.004 |
0.387 |
|
| 2012 |
Cully M, Downward J. Assessing cell size and cell cycle regulation in cells with altered TOR activity. Methods in Molecular Biology (Clifton, N.J.). 821: 227-37. PMID 22125068 DOI: 10.1007/978-1-61779-430-8_13 |
0.342 |
|
| 2012 |
Lee AJ, Roylance R, Sander J, Gorman P, Endesfelder D, Kschischo M, Jones NP, East P, Nicke B, Spassieva S, Obeid LM, Birkbak NJ, Szallasi Z, McKnight NC, Rowan AJ, ... ... Downward J, et al. CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction. The Journal of Pathology. 226: 482-94. PMID 21953249 DOI: 10.1002/Path.2998 |
0.335 |
|
| 2012 |
Downward J. Abstract IA12: Targeting unique dependencies of RAS mutant tumors. Cancer Research. 72. DOI: 10.1158/1538-7445.Panca2012-Ia12 |
0.444 |
|
| 2012 |
Gerlinger M, Rowan A, Horswell S, Larkin J, Endesfelder D, Gronroos E, Martinez P, Matthews N, Stewart A, Tarpey P, Varela I, Phillimore B, Begum S, McDonald N, Butler A, ... ... Downward J, et al. Abstract 964: Intra-tumor heterogeneity and Darwinian selection revealed by multi-region exome sequencing of renal cell carcinomas Cancer Research. 72: 964-964. DOI: 10.1158/1538-7445.Am2012-964 |
0.303 |
|
| 2012 |
Weigelt B, Warne PH, Lambros M, Reis-Filho JS, Downward J. Abstract 4835: Genetic determinants of mTOR inhibitor response in breast and endometrial cancer Cancer Research. 72: 4835-4835. DOI: 10.1158/1538-7445.Am2012-4835 |
0.393 |
|
| 2012 |
Molina-Arcas M, Hancock D, Steckel M, Downward J. Abstract 4163: Determination of synthetic lethal interactions in KRAS oncogene dependent cancer cells reveals novel therapeutic targeting strategies Cancer Research. 72: 4163-4163. DOI: 10.1158/1538-7445.Am2012-4163 |
0.472 |
|
| 2012 |
Cowell CF, De Bruin EC, Howell M, Downward J. Abstract A17: Loss of DEPTOR increases resistance to EGFR tyrosine kinase inhibitors by upregulating EGFR and MAPK signaling Clinical Cancer Research. 18: A17-A17. DOI: 10.1158/1078-0432.Mechres-A17 |
0.414 |
|
| 2012 |
Kumar MS, Downward J. Abstract A26: GATA2 is necessary for oncogene-mutant non-small cell lung tumorigenesis Clinical Cancer Research. 18: A26-A26. DOI: 10.1158/1078-0432.12Aacriaslc-A26 |
0.409 |
|
| 2012 |
Molina Arcas M, Hancock D, Steckel M, Downward J. 374 Determination of Synthetic Lethal Interactions in KRAS Oncogene Dependent Cancer Cells Reveals Novel Therapeutic Targeting Strategies European Journal of Cancer. 48: S90-S91. DOI: 10.1016/S0959-8049(12)71060-2 |
0.332 |
|
| 2012 |
Zeller KS, Idevall-Hagren O, Stefansson A, Velling T, Jackson SP, Downward J, Tengholm A, Johansson S. Corrigendum to “PI3-kinase p110α mediates β1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading” [Cell. Signal. 22 (2010) 1838–1848] Cellular Signalling. 24: 971-972. DOI: 10.1016/J.Cellsig.2011.12.010 |
0.39 |
|
| 2011 |
Castellano E, Downward J. RAS Interaction with PI3K: More Than Just Another Effector Pathway. Genes & Cancer. 2: 261-74. PMID 21779497 DOI: 10.1177/1947601911408079 |
0.461 |
|
| 2011 |
Lara R, Mauri FA, Taylor H, Derua R, Shia A, Gray C, Nicols A, Shiner RJ, Schofield E, Bates PA, Waelkens E, Dallman M, Lamb J, Zicha D, Downward J, et al. An siRNA screen identifies RSK1 as a key modulator of lung cancer metastasis. Oncogene. 30: 3513-21. PMID 21423205 DOI: 10.1038/Onc.2011.61 |
0.363 |
|
| 2011 |
Downward J. Targeting RAF: trials and tribulations. Nature Medicine. 17: 286-8. PMID 21383738 DOI: 10.1038/Nm0311-286 |
0.34 |
|
| 2011 |
Lee AJ, Endesfelder D, Rowan AJ, Walther A, Birkbak NJ, Futreal PA, Downward J, Szallasi Z, Tomlinson IP, Howell M, Kschischo M, Swanton C. Chromosomal instability confers intrinsic multidrug resistance. Cancer Research. 71: 1858-70. PMID 21363922 DOI: 10.1158/0008-5472.Can-10-3604 |
0.337 |
|
| 2011 |
Weigelt B, Warne PH, Downward J. PIK3CA mutation, but not PTEN loss of function, determines the sensitivity of breast cancer cells to mTOR inhibitory drugs. Oncogene. 30: 3222-33. PMID 21358673 DOI: 10.1038/Onc.2011.42 |
0.416 |
|
| 2011 |
Castellano E, Downward J. Role of RAS in the regulation of PI 3-kinase. Current Topics in Microbiology and Immunology. 346: 143-69. PMID 20563706 DOI: 10.1007/82_2010_56 |
0.475 |
|
| 2011 |
Bruin ECd, Cowell CF, Howell M, Varmus HE, Politi K, Downward J. Abstract LB-398: Identification of novel mechanisms of resistance to EGFR tyrosine kinase inhibitors in non-small cell lung cancer Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-398 |
0.404 |
|
| 2011 |
Lara R, Mauri FA, Taylor H, Derua R, Shia A, Gray C, Nicols A, Shiner RJ, Schofield E, Bates PA, Waelkens E, Dallman M, Lamb J, Zicha D, Downward J, et al. Abstract LB-356: An siRNA screen identifies Rsk1 as a key modulator of lung cancer metastasis Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-356 |
0.369 |
|
| 2011 |
Murillo MM, Tilley F, Lassailly F, Downward J. Abstract A169: The role of the RAS-PI3K interaction in tumor maintenance and metastasis. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-A169 |
0.386 |
|
| 2010 |
Vento MT, Zazzu V, Loffreda A, Cross JR, Downward J, Stoppelli MP, Iaccarino I. Praf2 is a novel Bcl-xL/Bcl-2 interacting protein with the ability to modulate survival of cancer cells. Plos One. 5: e15636. PMID 21203533 DOI: 10.1371/Journal.Pone.0015636 |
0.624 |
|
| 2010 |
Zeller KS, Idevall-Hagren O, Stefansson A, Velling T, Jackson SP, Downward J, Tengholm A, Johansson S. PI3-kinase p110α mediates β1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading. Cellular Signalling. 22: 1838-48. PMID 20667469 DOI: 10.1016/J.Cellsig.2010.07.011 |
0.444 |
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| 2010 |
Wang Y, Ngo VN, Marani M, Yang Y, Wright G, Staudt LM, Downward J. Critical role for transcriptional repressor Snail2 in transformation by oncogenic RAS in colorectal carcinoma cells. Oncogene. 29: 4658-70. PMID 20562906 DOI: 10.1038/Onc.2010.218 |
0.414 |
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| 2010 |
Alfano D, Votta G, Schulze A, Downward J, Caputi M, Stoppelli MP, Iaccarino I. Modulation of cellular migration and survival by c-Myc through the downregulation of urokinase (uPA) and uPA receptor. Molecular and Cellular Biology. 30: 1838-51. PMID 20123981 DOI: 10.1128/Mcb.01442-09 |
0.361 |
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| 2010 |
Cully M, Genevet A, Warne P, Treins C, Liu T, Bastien J, Baum B, Tapon N, Leevers SJ, Downward J. A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1. Molecular and Cellular Biology. 30: 481-95. PMID 19917724 DOI: 10.1128/Mcb.00688-09 |
0.414 |
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| 2010 |
Treins C, Downward J. 5 - mTORC2: The Other Facet of mTOR The Enzymes. 28: 99-124. DOI: 10.1016/S1874-6047(10)28005-8 |
0.363 |
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| 2009 |
Chua BT, Gallego-Ortega D, Ramirez de Molina A, Ullrich A, Lacal JC, Downward J. Regulation of Akt(ser473) phosphorylation by choline kinase in breast carcinoma cells. Molecular Cancer. 8: 131. PMID 20042122 DOI: 10.1186/1476-4598-8-131 |
0.439 |
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| 2009 |
Treins C, Warne PH, Magnuson MA, Pende M, Downward J. Rictor is a novel target of p70 S6 kinase-1. Oncogene. 29: 1003-16. PMID 19935711 DOI: 10.1038/Onc.2009.401 |
0.409 |
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| 2009 |
Downward J. Cancer: A tumour gene's fatal flaws. Nature. 462: 44-5. PMID 19890318 DOI: 10.1038/462044A |
0.351 |
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| 2009 |
Swanton C, Nicke B, Schuett M, Eklund AC, Ng C, Li Q, Hardcastle T, Lee A, Roy R, East P, Kschischo M, Endesfelder D, Wylie P, Kim SN, Chen JG, ... ... Downward J, et al. Chromosomal instability determines taxane response. Proceedings of the National Academy of Sciences of the United States of America. 106: 8671-6. PMID 19458043 DOI: 10.1073/Pnas.0811835106 |
0.311 |
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| 2009 |
Downward J, Hahn WC. Genetic and cellular mechanisms of oncogenesis Current Opinion in Genetics and Development. 19: 1-3. PMID 19208465 DOI: 10.1016/J.Gde.2009.01.001 |
0.415 |
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| 2009 |
Burrell RA, McClelland SE, Juul NS, Downward J, Szallasi ZI, Swanton C. Regulators of Mitotic Transition Determine Paclitaxel Resistance In Vitro and Predict Poor Prognosis in Breast Cancer In Vivo. Cancer Research. 69: 2151-2151. DOI: 10.1158/0008-5472.Sabcs-09-2151 |
0.353 |
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| 2009 |
Juul NS, Eklund AC, Li Q, Downward J, Burrell R, Szallasi ZI, Swanton C. A Functional Metagene Incorporating TTK Protein Kinase, Aurora Kinase B and Glucosylceramide Synthase Predicts Response to Treatment in Primary Breast Cancer Cancer Research. 69: 2032-2032. DOI: 10.1158/0008-5472.Sabcs-09-2032 |
0.324 |
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| 2008 |
Downward J. Targeting RAS and PI3K in lung cancer. Nature Medicine. 14: 1315-6. PMID 19057554 DOI: 10.1038/Nm1208-1315 |
0.458 |
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| 2008 |
Swanton C, Szallasi Z, Brenton JD, Downward J. Functional genomic analysis of drug sensitivity pathways to guide adjuvant strategies in breast cancer. Breast Cancer Research : Bcr. 10: 214. PMID 18986507 DOI: 10.1186/Bcr2159 |
0.305 |
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| 2008 |
Cully M, Downward J. SnapShot: Ras Signaling. Cell. 133: 1292-1292.e1. PMID 18585361 DOI: 10.1016/J.Cell.2008.06.020 |
0.453 |
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| 2008 |
Buday L, Downward J. Many faces of Ras activation. Biochimica Et Biophysica Acta. 1786: 178-87. PMID 18541156 DOI: 10.1016/J.Bbcan.2008.05.001 |
0.414 |
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| 2008 |
Cross JR, Postigo A, Blight K, Downward J. Viral pro-survival proteins block separate stages in Bax activation but changes in mitochondrial ultrastructure still occur. Cell Death and Differentiation. 15: 997-1008. PMID 18274554 DOI: 10.1038/Cdd.2008.14 |
0.602 |
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| 2008 |
Swanton C, Downward J. Unraveling the complexity of endocrine resistance in breast cancer by functional genomics. Cancer Cell. 13: 83-5. PMID 18242507 DOI: 10.1016/J.Ccr.2008.01.021 |
0.328 |
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| 2007 |
Ahmed AA, Mills AD, Ibrahim AE, Temple J, Blenkiron C, Vias M, Massie CE, Iyer NG, McGeoch A, Crawford R, Nicke B, Downward J, Swanton C, Bell SD, Earl HM, et al. The extracellular matrix protein TGFBI induces microtubule stabilization and sensitizes ovarian cancers to paclitaxel. Cancer Cell. 12: 514-27. PMID 18068629 DOI: 10.1016/J.Ccr.2007.11.014 |
0.342 |
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| 2007 |
Ramjaun AR, Downward J. Ras and phosphoinositide 3-kinase: partners in development and tumorigenesis. Cell Cycle (Georgetown, Tex.). 6: 2902-5. PMID 17993782 DOI: 10.4161/Cc.6.23.4996 |
0.454 |
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| 2007 |
Plun-Favreau H, Klupsch K, Moisoi N, Gandhi S, Kjaer S, Frith D, Harvey K, Deas E, Harvey RJ, McDonald N, Wood NW, Martins LM, Downward J. The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. Nature Cell Biology. 9: 1243-52. PMID 17906618 DOI: 10.1038/Ncb1644 |
0.337 |
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| 2007 |
Wells V, Downward J, Mallucci L. Functional inhibition of PI3K by the βGBP molecule suppresses Ras-MAPK signalling to block cell proliferation Oncogene. 26: 7709-7714. PMID 17603562 DOI: 10.1038/Sj.Onc.1210580 |
0.478 |
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| 2007 |
Swanton C, Marani M, Pardo O, Warne PH, Kelly G, Sahai E, Elustondo F, Chang J, Temple J, Ahmed AA, Brenton JD, Downward J, Nicke B. Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs. Cancer Cell. 11: 498-512. PMID 17560332 DOI: 10.1016/J.Ccr.2007.04.011 |
0.322 |
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| 2007 |
Gupta S, Ramjaun AR, Haiko P, Wang Y, Warne PH, Nicke B, Nye E, Stamp G, Alitalo K, Downward J. Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice. Cell. 129: 957-68. PMID 17540175 DOI: 10.1016/J.Cell.2007.03.051 |
0.448 |
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| 2007 |
Delpuech O, Griffiths B, East P, Essafi A, Lam EW, Burgering B, Downward J, Schulze A. Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expression. Molecular and Cellular Biology. 27: 4917-30. PMID 17452451 DOI: 10.1128/Mcb.01789-06 |
0.413 |
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| 2007 |
Calleja V, Alcor D, Laguerre M, Park J, Vojnovic B, Hemmings BA, Downward J, Parker PJ, Larijani B. Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo. Plos Biology. 5: e95. PMID 17407381 DOI: 10.1371/Journal.Pbio.0050095 |
0.391 |
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| 2007 |
Buday L, Downward J. Roles of cortactin in tumor pathogenesis. Biochimica Et Biophysica Acta. 1775: 263-73. PMID 17292556 DOI: 10.1016/J.Bbcan.2006.12.002 |
0.372 |
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| 2007 |
Ripka S, König A, Buchholz M, Wagner M, Sipos B, Klöppel G, Downward J, Gress TM, Michl P. WNT5A - Target of CUTL1 and potent modulator of tumor cell migration and invasion in pancreatic cancer Carcinogenesis. 28: 1178-1187. PMID 17227781 DOI: 10.1093/Carcin/Bgl255 |
0.312 |
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| 2007 |
Ramjaun AR, Tomlinson S, Eddaoudi A, Downward J. Upregulation of two BH3-only proteins, Bmf and Bim, during TGF beta-induced apoptosis. Oncogene. 26: 970-81. PMID 16909112 DOI: 10.1038/Sj.Onc.1209852 |
0.347 |
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| 2006 |
Downward J. Signal transduction. Prelude to an anniversary for the RAS oncogene. Science (New York, N.Y.). 314: 433-4. PMID 17053139 DOI: 10.1126/Science.1134727 |
0.381 |
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| 2006 |
Echeverri CJ, Beachy PA, Baum B, Boutros M, Buchholz F, Chanda SK, Downward J, Ellenberg J, Fraser AG, Hacohen N, Hahn WC, Jackson AL, Kiger A, Linsley PS, Lum L, et al. Minimizing the risk of reporting false positives in large-scale RNAi screens. Nature Methods. 3: 777-9. PMID 16990807 DOI: 10.1038/Nmeth1006-777 |
0.408 |
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| 2006 |
Pardo OE, Wellbrock C, Khanzada UK, Aubert M, Arozarena I, Davidson S, Bowen F, Parker PJ, Filonenko VV, Gout IT, Sebire N, Marais R, Downward J, Seckl MJ. FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2. The Embo Journal. 25: 3078-88. PMID 16810323 DOI: 10.1038/Sj.Emboj.7601198 |
0.41 |
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| 2006 |
Katso RM, Pardo OE, Palamidessi A, Franz CM, Marinov M, De Laurentiis A, Downward J, Scita G, Ridley AJ, Waterfield MD, Arcaro A. Phosphoinositide 3-Kinase C2beta regulates cytoskeletal organization and cell migration via Rac-dependent mechanisms. Molecular Biology of the Cell. 17: 3729-44. PMID 16775008 DOI: 10.1091/Mbc.E05-11-1083 |
0.619 |
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| 2006 |
Janda E, Nevolo M, Lehmann K, Downward J, Beug H, Grieco M. Raf plus TGFbeta-dependent EMT is initiated by endocytosis and lysosomal degradation of E-cadherin. Oncogene. 25: 7117-30. PMID 16751808 DOI: 10.1038/Sj.Onc.1209701 |
0.329 |
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| 2006 |
Swanton C, Tomlinson I, Downward J. Chromosomal instability, colorectal cancer and taxane resistance. Cell Cycle (Georgetown, Tex.). 5: 818-23. PMID 16628000 DOI: 10.4161/Cc.5.8.2682 |
0.301 |
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| 2006 |
Jansson AL, Yasmin L, Warne P, Downward J, Palmer RH, Hallberg B. Exoenzyme S of Pseudomonas aeruginosa is not able to induce apoptosis when cells express activated proteins, such as Ras or protein kinase B/Akt. Cellular Microbiology. 8: 815-22. PMID 16611230 DOI: 10.1111/J.1462-5822.2005.00668.X |
0.453 |
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| 2006 |
Michl P, Knobel B, Downward J. CUTL1 is phosphorylated by protein kinase A, modulating its effects on cell proliferation and motility. The Journal of Biological Chemistry. 281: 15138-44. PMID 16574653 DOI: 10.1074/Jbc.M600908200 |
0.422 |
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| 2006 |
Shin SY, Bahk YY, Ko J, Chung IY, Lee YS, Downward J, Eibel H, Sharma PM, Olefsky JM, Kim YH, Lee B, Lee YH. Suppression of Egr-1 transcription through targeting of the serum response factor by oncogenic H-Ras. The Embo Journal. 25: 1093-103. PMID 16456537 DOI: 10.1038/Sj.Emboj.7600987 |
0.434 |
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| 2006 |
Postigo A, Cross JR, Downward J, Way M. Interaction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosis Cell Death and Differentiation. 13: 1651-1662. PMID 16439990 DOI: 10.1038/Sj.Cdd.4401853 |
0.6 |
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| 2006 |
Michl P, Downward J. CUTL1: a key mediator of TGFbeta-induced tumor invasion. Cell Cycle (Georgetown, Tex.). 5: 132-4. PMID 16357536 DOI: 10.4161/Cc.5.2.2311 |
0.362 |
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| 2006 |
Khanzada UK, Pardo OE, Meier C, Downward J, Seckl MJ, Arcaro A. Potent inhibition of small-cell lung cancer cell growth by simvastatin reveals selective functions of Ras isoforms in growth factor signalling. Oncogene. 25: 877-87. PMID 16170339 DOI: 10.1038/Sj.Onc.1209117 |
0.475 |
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| 2005 |
Nicke B, Bastien J, Khanna SJ, Warne PH, Cowling V, Cook SJ, Peters G, Delpuech O, Schulze A, Berns K, Mullenders J, Beijersbergen RL, Bernards R, Ganesan TS, Downward J, et al. Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells. Molecular Cell. 20: 673-85. PMID 16337592 DOI: 10.1016/J.Molcel.2005.10.038 |
0.485 |
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| 2005 |
Michl P, Downward J. Mechanisms of disease: PI3K/AKT signaling in gastrointestinal cancers. Zeitschrift Fur Gastroenterologie. 43: 1133-9. PMID 16220453 DOI: 10.1055/S-2005-858638 |
0.453 |
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| 2005 |
Porstmann T, Griffiths B, Chung YL, Delpuech O, Griffiths JR, Downward J, Schulze A. PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP. Oncogene. 24: 6465-81. PMID 16007182 DOI: 10.1038/Sj.Onc.1208802 |
0.352 |
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| 2005 |
Michl P, Ramjaun AR, Pardo OE, Warne PH, Wagner M, Poulsom R, D'Arrigo C, Ryder K, Menke A, Gress T, Downward J. CUTL1 is a target of TGF(beta) signaling that enhances cancer cell motility and invasiveness. Cancer Cell. 7: 521-32. PMID 15950902 DOI: 10.1016/J.Ccr.2005.05.018 |
0.356 |
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| 2005 |
Baksh S, Tommasi S, Fenton S, Yu VC, Martins LM, Pfeifer GP, Latif F, Downward J, Neel BG. The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to bax conformational change and cell death Molecular Cell. 18: 637-650. PMID 15949439 DOI: 10.1016/J.Molcel.2005.05.010 |
0.309 |
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| 2005 |
Stoll V, Calleja V, Vassaux G, Downward J, Lemoine NR. Dominant negative inhibitors of signalling through the phosphoinositol 3-kinase pathway for gene therapy of pancreatic cancer Gut. 54: 109-116. PMID 15591514 DOI: 10.1136/Gut.2004.046706 |
0.439 |
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| 2005 |
Downward J. Ras regulation: putting back the GTP. Current Biology : Cb. 2: 329-31. PMID 15335949 DOI: 10.1016/0960-9822(92)90897-J |
0.401 |
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| 2004 |
Martins LM, Morrison A, Klupsch K, Fedele V, Moisoi N, Teismann P, Abuin A, Grau E, Geppert M, Livi GP, Creasy CL, Martin A, Hargreaves I, Heales SJ, Okada H, ... ... Downward J, et al. Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice. Molecular and Cellular Biology. 24: 9848-62. PMID 15509788 DOI: 10.1128/Mcb.24.22.9848-9862.2004 |
0.335 |
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| 2004 |
Downward J. PI 3-kinase, Akt and cell survival. Seminars in Cell & Developmental Biology. 15: 177-82. PMID 15209377 DOI: 10.1016/J.Semcdb.2004.01.002 |
0.464 |
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| 2004 |
Dallol A, Agathanggelou A, Fenton SL, Ahmed-Choudhury J, Hesson L, Vos MD, Clark GJ, Downward J, Maher ER, Latif F. RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics. Cancer Research. 64: 4112-6. PMID 15205320 DOI: 10.1158/0008-5472.Can-04-0267 |
0.331 |
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| 2004 |
Schulze A, Nicke B, Warne PH, Tomlinson S, Downward J. The transcriptional response to Raf activation is almost completely dependent on Mitogen-activated Protein Kinase Kinase activity and shows a major autocrine component. Molecular Biology of the Cell. 15: 3450-63. PMID 15090615 DOI: 10.1091/Mbc.E03-11-0807 |
0.47 |
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| 2004 |
Fenton SL, Dallol A, Agathanggelou A, Hesson L, Ahmed-Choudhury J, Baksh S, Sardet C, Dammann R, Minna JD, Downward J, Maher ER, Latif F. Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene. Cancer Research. 64: 102-7. PMID 14729613 DOI: 10.1158/0008-5472.Can-03-2622 |
0.367 |
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| 2004 |
Marani M, Hancock D, Lopes R, Tenev T, Downward J, Lemoine NR. Role of Bim in the survival pathway induced by Raf in epithelial cells Oncogene. 23: 2431-2441. PMID 14676826 DOI: 10.1038/Sj.Onc.1207364 |
0.459 |
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| 2004 |
Downward J. Role of receptor tyrosine kinases in G-protein-coupled receptor regulation of Ras: transactivation or parallel pathways? The Biochemical Journal. 376: e9-10. PMID 14656216 DOI: 10.1042/Bj20031745 |
0.425 |
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| 2004 |
Downward J. Use of RNA interference libraries to investigate oncogenic signalling in mammalian cells Oncogene. 23: 8376-8383. DOI: 10.1038/Sj.Onc.1208073 |
0.312 |
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| 2003 |
Pardo OE, Lesay A, Arcaro A, Lopes R, Ng BL, Warne PH, McNeish IA, Tetley TD, Lemoine NR, Mehmet H, Seckl MJ, Downward J. Fibroblast Growth Factor 2-Mediated Translational Control of IAPs Blocks Mitochondrial Release of Smac/DIABLO and Apoptosis in Small Cell Lung Cancer Cells Molecular and Cellular Biology. 23: 7600-7610. PMID 14560006 DOI: 10.1128/Mcb.23.21.7600-7610.2003 |
0.395 |
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| 2003 |
Martins LM, Turk BE, Cowling V, Borg A, Jarrell ET, Cantley LC, Downward J. Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi. The Journal of Biological Chemistry. 278: 49417-27. PMID 14512424 DOI: 10.1074/Jbc.M308659200 |
0.347 |
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| 2003 |
Calleja V, Ameer-Beg SM, Vojnovic B, Woscholski R, Downward J, Larijani B. Monitoring conformational changes of proteins in cells by fluorescence lifetime imaging microscopy. The Biochemical Journal. 372: 33-40. PMID 12662152 DOI: 10.1042/Bj20030358 |
0.332 |
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| 2003 |
Basu S, Totty NF, Irwin MS, Sudol M, Downward J. Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis. Molecular Cell. 11: 11-23. PMID 12535517 DOI: 10.1016/S1097-2765(02)00776-1 |
0.407 |
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| 2003 |
Downward J. Targeting RAS signalling pathways in cancer therapy. Nature Reviews. Cancer. 3: 11-22. PMID 12509763 DOI: 10.1038/Nrc969 |
0.418 |
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| 2003 |
Tamás P, Solti Z, Bauer P, Illés A, Sipeki S, Bauer A, Faragó A, Downward J, Buday L. Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide exchange factor for Rac. The Journal of Biological Chemistry. 278: 5163-71. PMID 12454019 DOI: 10.1074/Jbc.M207555200 |
0.463 |
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| 2003 |
Khanna S, Warnasuriya GD, Downward J, Naaby-Hansen S. RNAi and 2DE, a promising combination for analysis of phospho-signalling and substrate identification Letters in Peptide Science. 10: 437-445. DOI: 10.1007/S10989-004-3533-X |
0.443 |
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| 2002 |
Nicolás FJ, Lehmann K, Warne PH, Hill CS, Downward J. Epithelial to mesenchymal transition in Madin-Darby canine kidney cells is accompanied by down-regulation of Smad3 expression, leading to resistance to transforming growth factor-beta-induced growth arrest. The Journal of Biological Chemistry. 278: 3251-6. PMID 12435725 DOI: 10.1074/Jbc.M209019200 |
0.312 |
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| 2002 |
Vyas S, Béchade C, Riveau B, Downward J, Triller A. Involvement of survival motor neuron (SMN) protein in cell death. Human Molecular Genetics. 11: 2751-64. PMID 12374765 DOI: 10.1093/Hmg/11.22.2751 |
0.34 |
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| 2002 |
Cowling V, Downward J. Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: absolute requirement for removal of caspase-6 prodomain. Cell Death and Differentiation. 9: 1046-56. PMID 12232792 DOI: 10.1038/Sj.Cdd.4401065 |
0.303 |
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| 2002 |
Janda E, Litos G, Grünert S, Downward J, Beug H. Oncogenic Ras/Her-2 mediate hyperproliferation of polarized epithelial cells in 3D cultures and rapid tumor growth via the PI3K pathway. Oncogene. 21: 5148-59. PMID 12140765 DOI: 10.1038/Sj.Onc.1205661 |
0.44 |
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| 2002 |
Edme N, Downward J, Thiery JP, Boyer B. Ras induces NBT-II epithelial cell scattering through the coordinate activities of Rac and MAPK pathways. Journal of Cell Science. 115: 2591-601. PMID 12045229 DOI: 10.1242/jcs.115.12.2591 |
0.339 |
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| 2002 |
Marani M, Tenev T, Hancock D, Downward J, Lemoine NR. Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis. Molecular and Cellular Biology. 22: 3577-89. PMID 11997495 DOI: 10.1128/Mcb.22.11.3577-3589.2002 |
0.344 |
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| 2002 |
Reynolds LF, Smyth LA, Norton T, Freshney N, Downward J, Kioussis D, Tybulewicz VL. Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways. The Journal of Experimental Medicine. 195: 1103-14. PMID 11994416 DOI: 10.1084/Jem.20011663 |
0.398 |
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| 2002 |
Pardo OE, Arcaro A, Salerno G, Raguz S, Downward J, Seckl MJ. Fibroblast growth factor-2 induces translational regulation of Bcl-XL and Bcl-2 via a MEK-dependent pathway: correlation with resistance to etoposide-induced apoptosis. The Journal of Biological Chemistry. 277: 12040-6. PMID 11815602 DOI: 10.1074/jbc.M109006200 |
0.341 |
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| 2002 |
Inabe K, Ishiai M, Scharenberg AM, Freshney N, Downward J, Kurosaki T. Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation. The Journal of Experimental Medicine. 195: 189-200. PMID 11805146 DOI: 10.1084/Jem.20011571 |
0.425 |
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| 2002 |
Janda E, Lehmann K, Killisch I, Jechlinger M, Herzig M, Downward J, Beug H, Grünert S. Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways. The Journal of Cell Biology. 156: 299-313. PMID 11790801 DOI: 10.1083/Jcb.200109037 |
0.459 |
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| 2002 |
Martins LM, Iaccarino I, Tenev T, Gschmeissner S, Totty NF, Lemoine NR, Savopoulos J, Gray CW, Creasy CL, Dingwall C, Downward J. The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif. The Journal of Biological Chemistry. 277: 439-44. PMID 11602612 DOI: 10.1074/Jbc.M109784200 |
0.342 |
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| 2001 |
Scibetta AG, Albanese I, Morris J, Cooper L, Downward J, Rowe PP, Taylor-Papadimitriou J. Regulation of MUC1 expression in human mammary cell lines by the c-ErbB2 and ras signaling pathways. Dna and Cell Biology. 20: 265-74. PMID 11410163 DOI: 10.1089/104454901750232463 |
0.433 |
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| 2001 |
Rodriguez-Viciana P, Downward J. Ras activation of phosphatidylinositol 3-kinase and Akt. Methods in Enzymology. 333: 37-44. PMID 11400352 DOI: 10.1016/S0076-6879(01)33042-2 |
0.429 |
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| 2001 |
Schulze A, Lehmann K, Jefferies HBJ, McMahon M, Downward J. Analysis of the transcriptional program induced by Raf in epithelial cells Genes & Development. 15: 981-994. PMID 11316792 DOI: 10.1101/Gad.191101 |
0.445 |
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| 2001 |
Berrier AL, Mastrangelo AM, Downward J, Ginsberg M, LaFlamme SE. Activated R-ras, Rac1, PI 3-kinase and PKCepsilon can each restore cell spreading inhibited by isolated integrin beta1 cytoplasmic domains. The Journal of Cell Biology. 151: 1549-60. PMID 11134082 DOI: 10.1083/Jcb.151.7.1549 |
0.439 |
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| 2001 |
Downward J, Leevers SJ. Trachealess—A New Transcription Factor Target for PKB/Akt Developmental Cell. 1: 726-728. DOI: 10.1016/S1534-5807(01)00099-5 |
0.336 |
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| 2001 |
Rubio I, Downward J. Ras activation revisited Signal Transduction. 1: 11-24. DOI: 10.1002/1615-4061(200101)1:1+<11::Aid-Sita11>3.0.Co;2-J |
0.378 |
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| 2000 |
Oertli B, Han J, Marte BM, Sethi T, Downward J, Ginsberg M, Hughes PE. The effector loop and prenylation site of R-Ras are involved in the regulation of integrin function Oncogene. 19: 4961-4969. PMID 11042683 DOI: 10.1038/Sj.Onc.1203876 |
0.397 |
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| 2000 |
Lehmann K, Janda E, Pierreux CE, Rytömaa M, Schulze A, McMahon M, Hill CS, Beug H, Downward J. Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells. Genes & Development. 14: 2610-2622. PMID 11040215 DOI: 10.1101/Gad.181700 |
0.456 |
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| 2000 |
Rytömaa M, Lehmann K, Downward J. Matrix detachment induces caspase-dependent cytochrome c release from mitochondria: inhibition by PKB/Akt but not Raf signalling. Oncogene. 19: 4461-8. PMID 11002418 DOI: 10.1038/Sj.Onc.1203805 |
0.379 |
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| 2000 |
Odajima J, Matsumura I, Sonoyama J, Daino H, Kawasaki A, Tanaka H, Inohara N, Kitamura T, Downward J, Nakajima K, Hirano T, Kanakura Y. Full oncogenic activities of v-Src are mediated by multiple signaling pathways. Ras as an essential mediator for cell survival. The Journal of Biological Chemistry. 275: 24096-105. PMID 10918073 DOI: 10.1074/Jbc.M001606200 |
0.462 |
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| 2000 |
Kinashi T, Katagiri K, Watanabe S, Vanhaesebroeck B, Downward J, Takatsu K. Distinct mechanisms of alpha 5beta 1 integrin activation by Ha-Ras and R-Ras. The Journal of Biological Chemistry. 275: 22590-6. PMID 10801791 DOI: 10.1074/Jbc.M000633200 |
0.42 |
|
| 2000 |
Rubio I, Wittig U, Meyer C, Heinze R, Kadereit D, Waldmann H, Downward J, Wetzker R. Farnesylation of Ras is important for the interaction with phosphoinositide 3-kinase gamma. European Journal of Biochemistry. 266: 70-82. PMID 10542052 DOI: 10.1046/J.1432-1327.1999.00815.X |
0.402 |
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| 2000 |
Rytömaa M, Martins LM, Downward J. Involvement of FADD and caspase-8 signalling in detachment-induced apoptosis. Current Biology : Cb. 9: 1043-6. PMID 10508619 DOI: 10.1016/S0960-9822(99)80454-0 |
0.39 |
|
| 2000 |
Clissi B, D’Ambrosio D, Geginat J, Colantonio L, Morrot A, Freshney NW, Downward J, Sinigaglia F, Pardi R. Chemokines Fail to Up-Regulate β1Integrin-Dependent Adhesion in Human Th2 T Lymphocytes The Journal of Immunology. 164: 3292-3300. DOI: 10.4049/Jimmunol.164.6.3292 |
0.358 |
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| 1999 |
Downward J. How BAD phosphorylation is good for survival. Nature Cell Biology. 1: E33-5. PMID 10559890 DOI: 10.1038/10026 |
0.353 |
|
| 1999 |
Altiok S, Batt D, Altiok N, Papautsky A, Downward J, Roberts TM, Avraham H. Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells. The Journal of Biological Chemistry. 274: 32274-8. PMID 10542266 DOI: 10.1074/Jbc.274.45.32274 |
0.423 |
|
| 1999 |
Ashcroft M, Stephens RM, Hallberg B, Downward J, Kaplan DR. The selective and inducible activation of endogenous PI 3-kinase in PC12 cells results in efficient NGF-mediated survival but defective neurite outgrowth Oncogene. 18: 4586-4597. PMID 10467403 DOI: 10.1038/Sj.Onc.1202814 |
0.433 |
|
| 1999 |
Gille H, Downward J. Multiple ras effector pathways contribute to G(1) cell cycle progression. The Journal of Biological Chemistry. 274: 22033-40. PMID 10419529 DOI: 10.1074/Jbc.274.31.22033 |
0.461 |
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| 1999 |
Wunderlich L, Gohér A, Faragó A, Downward J, Buday L. Requirement of multiple SH3 domains of Nck for ligand binding. Cellular Signalling. 11: 253-62. PMID 10372803 DOI: 10.1016/S0898-6568(98)00054-0 |
0.335 |
|
| 1999 |
Sethi T, Ginsberg MH, Downward J, Hughes PE. The small GTP-binding protein R-Ras can influence integrin activation by antagonizing a Ras/Raf-initiated integrin suppression pathway Molecular Biology of the Cell. 10: 1799-1809. PMID 10359597 DOI: 10.1091/Mbc.10.6.1799 |
0.402 |
|
| 1999 |
Wennström S, Downward J. Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor. Molecular and Cellular Biology. 19: 4279-88. PMID 10330169 DOI: 10.1128/Mcb.19.6.4279 |
0.472 |
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| 1999 |
Wunderlich L, Faragó A, Downward J, Buday L. Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes. European Journal of Immunology. 29: 1068-75. PMID 10229072 DOI: 10.1002/(Sici)1521-4141(199904)29:04<1068::Aid-Immu1068>3.0.Co;2-P |
0.385 |
|
| 1999 |
Watton SJ, Downward J. Akt/PKB localisation and 3' phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction Current Biology. 9: 433-436. PMID 10226029 DOI: 10.1016/S0960-9822(99)80192-4 |
0.454 |
|
| 1999 |
Lockyer PJ, Wennström S, Kupzig S, Venkateswarlu K, Downward J, Cullen PJ. Identification of the ras GTPase-activating protein GAP1(m) as a phosphatidylinositol-3,4,5-trisphosphate-binding protein in vivo. Current Biology : Cb. 9: 265-8. PMID 10074452 DOI: 10.1016/S0960-9822(99)80116-X |
0.359 |
|
| 1999 |
McNeill H, Downward J. Apoptosis: Ras to the rescue in the fly eye. Current Biology : Cb. 9: R176-9. PMID 10074440 DOI: 10.1016/S0960-9822(99)80107-9 |
0.373 |
|
| 1999 |
Matsumura I, Kitamura T, Wakao H, Tanaka H, Hashimoto K, Albanese C, Downward J, Pestell RG, Kanakura Y. Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells. The Embo Journal. 18: 1367-77. PMID 10064602 DOI: 10.1093/Emboj/18.5.1367 |
0.358 |
|
| 1999 |
Lockyer PJ, Wennström S, Kupzig S, Venkateswarlu K, Downward J, Cullen PJ. Identification of the Ras GTPase-activating protein GAP1m as an in vivo phosphatidylinositol 3,4,5-trisphosphate-binding protein Biochemical Society Transactions. 27: A104-A104. DOI: 10.1042/Bst027A104A |
0.371 |
|
| 1998 |
Downward J. Signal transduction. New exchange, new target. Nature. 396: 416-7. PMID 9853744 DOI: 10.1038/24743 |
0.368 |
|
| 1998 |
Arcaro A, Volinia S, Zvelebil MJ, Stein R, Watton SJ, Layton MJ, Gout I, Ahmadi K, Downward J, Waterfield MD. Human phosphoinositide 3-kinase C2β, the role of calcium and the C2 domain in enzyme activity Journal of Biological Chemistry. 273: 33082-33090. PMID 9830063 DOI: 10.1074/Jbc.273.49.33082 |
0.584 |
|
| 1998 |
Roche S, Downward J, Raynal P, Courtneidge SA. A function for phosphatidylinositol 3-kinase β (p85α-p110β) in fibroblasts during mitogenesis: Requirement for insulin- and lysophosphatidic acid-mediated signal transduction Molecular and Cellular Biology. 18: 7119-7129. PMID 9819398 DOI: 10.1128/Mcb.18.12.7119 |
0.434 |
|
| 1998 |
Fuller SJ, Finn SG, Downward J, Sugden PH. Stimulation of gene expression in neonatal rat ventricular myocytes by Ras is mediated by Ral guanine nucleotide dissociation stimulator (Ral.GDS) and phosphatidylinositol 3-kinase in addition to Raf Biochemical Journal. 335: 241-246. PMID 9761720 DOI: 10.1042/Bj3350241 |
0.39 |
|
| 1998 |
Hallberg B, Ashcroft M, Loeb DM, Kaplan DR, Downward J. Nerve growth factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide 3-OH kinase Oncogene. 17: 691-697. PMID 9715270 DOI: 10.1038/Sj.Onc.1201980 |
0.475 |
|
| 1998 |
Khwaja A, Lehmann K, Marte BM, Downward J. Phosphoinositide 3-kinase induces scattering and tubulogenesis in epithelial cells through a novel pathway. The Journal of Biological Chemistry. 273: 18793-801. PMID 9668053 DOI: 10.1074/Jbc.273.30.18793 |
0.449 |
|
| 1998 |
Downward J. Mechanisms and consequences of activation of protein kinase B/Akt. Current Opinion in Cell Biology. 10: 262-267. PMID 9561851 DOI: 10.1016/S0955-0674(98)80149-X |
0.436 |
|
| 1998 |
Downward J. Ras signalling and apoptosis. Current Opinion in Genetics & Development. 8: 49-54. PMID 9529605 DOI: 10.1016/S0959-437X(98)80061-0 |
0.467 |
|
| 1998 |
Van Weering DHJ, De Rooij J, Marte B, Downward J, Bos JL, Burgering BMT. Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras Molecular and Cellular Biology. 18: 1802-1811. PMID 9528752 DOI: 10.1128/Mcb.18.4.1802 |
0.478 |
|
| 1998 |
Downward J. Lipid-regulated kinases: some common themes at last. Science (New York, N.Y.). 279: 673-4. PMID 9471728 DOI: 10.1126/Science.279.5351.673 |
0.346 |
|
| 1998 |
Jimenez C, Jones DR, RodrÃguez-Viciana P, Gonzalez-GarcÃa A, Leonardo E, Wennström S, von Kobbe C, Toran JL, R-Borlado L, Calvo V, Copin SG, Albar JP, Gaspar ML, Diez E, Marcos MA, ... Downward J, et al. Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase. The Embo Journal. 17: 743-53. PMID 9450999 DOI: 10.1093/Emboj/17.3.743 |
0.42 |
|
| 1998 |
Denouel-Galy A, Douville EM, Warne PH, Papin C, Laugier D, Calothy G, Downward J, Eychène A. Murine Ksr interacts with MEK and inhibits Ras-induced transformation. Current Biology : Cb. 8: 46-55. PMID 9427625 DOI: 10.1016/S0960-9822(98)70019-3 |
0.449 |
|
| 1997 |
Khwaja A, Downward J. Lack of correlation between activation of Jun-NH2-terminal kinase and induction of apoptosis after detachment of epithelial cells. The Journal of Cell Biology. 139: 1017-23. PMID 9362519 DOI: 10.1083/Jcb.139.4.1017 |
0.445 |
|
| 1997 |
Downward J. Role of phosphoinositide-3-OH kinase in Ras signaling. Advances in Second Messenger and Phosphoprotein Research. 31: 1-10. PMID 9344237 DOI: 10.1016/S1040-7952(97)80004-3 |
0.302 |
|
| 1997 |
Rubio I, Rodriguez-Viciana P, Downward J, Wetzker R. Interaction of Ras with phosphoinositide 3-kinase gamma. The Biochemical Journal. 891-5. PMID 9307042 DOI: 10.1042/Bj3260891 |
0.426 |
|
| 1997 |
Marte BM, Downward J. PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond. Trends in Biochemical Sciences. 22: 355-8. PMID 9301337 DOI: 10.1016/S0968-0004(97)01097-9 |
0.436 |
|
| 1997 |
Douville E, Downward J. EGF induced SOS phosphorylation in PC12 cells involves P90 RSK-2. Oncogene. 15: 373-83. PMID 9242373 DOI: 10.1038/Sj.Onc.1201214 |
0.422 |
|
| 1997 |
Khwaja A, Rodriguez-Viciana P, Wennström S, Warne PH, Downward J. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. The Embo Journal. 16: 2783-93. PMID 9184223 DOI: 10.1093/Emboj/16.10.2783 |
0.479 |
|
| 1997 |
Downward J. Cell cycle: routine role for Ras. Current Biology : Cb. 7: R258-60. PMID 9162506 DOI: 10.1016/S0960-9822(06)00116-3 |
0.387 |
|
| 1997 |
Rodriguez-Viciana P, Warne PH, Khwaja A, Marte BM, Pappin D, Das P, Waterfield MD, Ridley A, Downward J. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell. 89: 457-67. PMID 9150145 DOI: 10.1016/S0092-8674(00)80226-3 |
0.632 |
|
| 1997 |
Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, Higashi K, Volinia S, Downward J, Waterfield MD. P110delta, a novel phosphoinositide 3-kinase in leukocytes. Proceedings of the National Academy of Sciences of the United States of America. 94: 4330-5. PMID 9113989 DOI: 10.1073/Pnas.94.9.4330 |
0.622 |
|
| 1997 |
Kauffmann-Zeh A, Rodriguez-Viciana P, Ulrich E, Gilbert C, Coffer P, Downward J, Evan G. Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB Nature. 385: 544-548. PMID 9020362 DOI: 10.1038/385544A0 |
0.453 |
|
| 1997 |
Marte BM, Rodriguez-Viciana P, Wennström S, Warne PH, Downward J. R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways. Current Biology : Cb. 7: 63-70. PMID 8999998 DOI: 10.1016/S0960-9822(06)00028-5 |
0.398 |
|
| 1996 |
Rodriguez-Viciana P, Warne PH, Vanhaesebroeck B, Waterfield MD, Downward J. Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation. The Embo Journal. 15: 2442-51. PMID 8665852 DOI: 10.1002/J.1460-2075.1996.Tb00602.X |
0.635 |
|
| 1996 |
Rodriguez-Viciana P, Marte BM, Warne PH, Downward J. Phosphatidylinositol 3' kinase: one of the effectors of Ras. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 351: 225-31; discussion 2. PMID 8650270 DOI: 10.1098/RSTB.1996.0020 |
0.354 |
|
| 1996 |
Buday L, Khwaja A, Sipeki S, Faragó A, Downward J. Interactions of Cbl with two adapter proteins, Grb2 and Crk, upon T cell activation. The Journal of Biological Chemistry. 271: 6159-63. PMID 8626404 DOI: 10.1074/Jbc.271.11.6159 |
0.417 |
|
| 1996 |
Downward J. KSR: a novel player in the RAS pathway. Cell. 83: 831-4. PMID 8521506 DOI: 10.1016/0092-8674(95)90198-1 |
0.438 |
|
| 1996 |
Downward J. The Protein Kinase Facts Book (Parts I and II) Immunology Today. 17: 49-50. DOI: 10.1016/0167-5699(96)80572-X |
0.334 |
|
| 1995 |
Wang W, Fisher EM, Jia Q, Dunn JM, Porfiri E, Downward J, Egan SE. The Grb2 binding domain of mSos1 is not required for downstream signal transduction. Nature Genetics. 10: 294-300. PMID 7670467 DOI: 10.1038/Ng0795-294 |
0.37 |
|
| 1995 |
Downward J. Signal transduction. A target for PI(3) kinase. Nature. 376: 553-4. PMID 7637799 DOI: 10.1038/376553A0 |
0.355 |
|
| 1995 |
Downward J. The Oncogene FactsBook Trends in Biochemical Sciences. 20: 486. DOI: 10.1016/S0968-0004(00)89109-4 |
0.372 |
|
| 1994 |
Downward J. The GRB2/Sem-5 adaptor protein. Febs Letters. 338: 113-7. PMID 8307166 DOI: 10.1016/0014-5793(94)80346-3 |
0.412 |
|
| 1994 |
Pronk GJ, de Vries-Smits AM, Buday L, Downward J, Maassen JA, Medema RH, Bos JL. Involvement of Shc in insulin- and epidermal growth factor-induced activation of p21ras. Molecular and Cellular Biology. 14: 1575-81. PMID 8114695 DOI: 10.1128/Mcb.14.3.1575 |
0.542 |
|
| 1994 |
Downward J. Signal transduction. Regulating S6 kinase. Nature. 371: 378-9. PMID 8090217 DOI: 10.1038/371378A0 |
0.353 |
|
| 1994 |
Rodriguez-Viciana P, Warne PH, Dhand R, Vanhaesebroeck B, Gout I, Fry MJ, Waterfield MD, Downward J. Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature. 370: 527-32. PMID 8052307 DOI: 10.1038/370527A0 |
0.622 |
|
| 1994 |
Arvidsson AK, Rupp E, Nånberg E, Downward J, Rönnstrand L, Wennström S, Schlessinger J, Heldin CH, Claesson-Welsh L. Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation. Molecular and Cellular Biology. 14: 6715-26. PMID 7935391 DOI: 10.1128/Mcb.14.10.6715 |
0.414 |
|
| 1993 |
Buday L, Downward J. Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor Cell. 73: 611-620. PMID 8490966 DOI: 10.1016/0092-8674(93)90146-H |
0.419 |
|
| 1993 |
Buday L, Downward J. Epidermal growth factor regulates the exchange rate of guanine nucleotides on p21ras in fibroblasts. Molecular and Cellular Biology. 13: 1903-1910. PMID 8441421 DOI: 10.1128/Mcb.13.3.1903 |
0.446 |
|
| 1993 |
Warne PH, Viciana PR, Downward J. Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro. Nature. 364: 352-5. PMID 8332195 DOI: 10.1038/364352A0 |
0.415 |
|
| 1993 |
Simon M, Dodson G, Rubin G, Olivier J, Egan S, Giddings B, Brooks M, Buday L, Sizeland A, Weinberg R, Rozakis-Adcock M, Fernley R, Wade J, Pawson T, Bowtell D, ... ... Downward J, et al. Tyrosine kinases to Ras Trends in Cell Biology. 3: 228. DOI: 10.1016/0962-8924(93)90117-J |
0.723 |
|
| 1993 |
Zhang X, Warne P, Viciana P, Downward J, Hughes D. Ras to raf to MAPKK Trends in Cell Biology. 3: 333. DOI: 10.1016/0962-8924(93)90098-L |
0.338 |
|
| 1992 |
Downward J. Regulation of p21ras by GTPase activating proteins and guanine nucleotide exchange proteins. Current Opinion in Genetics & Development. 2: 13-8. PMID 1633420 DOI: 10.1016/S0959-437X(05)80315-6 |
0.368 |
|
| 1992 |
Downward J, Graves J, Cantrell D. The regulation and function of p21ras in T cells. Immunology Today. 13: 89-92. PMID 1622545 DOI: 10.1016/0167-5699(92)90148-Z |
0.335 |
|
| 1992 |
Izquierdo M, Downward J, Graves JD, Cantrell DA. Role of protein kinase C in T-cell antigen receptor regulation of p21ras: evidence that two p21ras regulatory pathways coexist in T cells. Molecular and Cellular Biology. 12: 3305-12. PMID 1620132 DOI: 10.1128/Mcb.12.7.3305 |
0.414 |
|
| 1992 |
Basu TN, Gutmann DH, Fletcher JA, Glover TW, Collins FS, Downward J. Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients. Nature. 356: 713-5. PMID 1570015 DOI: 10.1038/356713A0 |
0.389 |
|
| 1992 |
Downward J. Regulation of p21ras by GTPase activating proteins and guanine nucleotide exchange proteins Current Biology. 2: 165. DOI: 10.1016/0960-9822(92)90282-F |
0.315 |
|
| 1992 |
Rayter S, Woodrow M, Lucas S, Cantrell D, Downward J. p21ras mediates control of IL-2 gene promoter function in T cell activation. The Embo Journal. 11: 4549-4556. DOI: 10.1002/J.1460-2075.1992.Tb05556.X |
0.406 |
|
| 1992 |
Downward J. Regulatory mechanisms forras proteins Bioessays. 14: 177-184. DOI: 10.1002/Bies.950140308 |
0.43 |
|
| 1991 |
Wang XF, Lin HY, Ng-Eaton E, Downward J, Lodish HF, Weinberg RA. Expression cloning and characterization of the TGF-beta type III receptor. Cell. 67: 797-805. PMID 1657407 DOI: 10.1016/0092-8674(91)90074-9 |
0.483 |
|
| 1990 |
Downward J, Riehl R, Wu L, Weinberg RA. Identification of a nucleotide exchange-promoting activity for p21ras. Proceedings of the National Academy of Sciences of the United States of America. 87: 5998-6002. PMID 2116014 DOI: 10.1073/Pnas.87.15.5998 |
0.546 |
|
| 1990 |
Downward J, Graves JD, Warne PH, Rayter S, Cantrell DA. Stimulation of p21ras upon T-cell activation Nature. 346: 719-723. DOI: 10.1038/346719A0 |
0.41 |
|
| 1990 |
Downward J. The ras superfamily of small GTP-binding proteins Trends in Biochemical Sciences. 15: 469-472. DOI: 10.1016/0968-0004(90)90300-Z |
0.373 |
|
| 1989 |
Hsuan JJ, Downward J, Clark S, Waterfield MD. Proteolytic generation of constitutive tyrosine kinase activity of the human insulin receptor. The Biochemical Journal. 259: 519-27. PMID 2719663 DOI: 10.1042/Bj2590519 |
0.566 |
|
| 1988 |
Collins MK, Downward J, Miyajima A, Maruyama K, Arai K, Mulligan RC. Transfer of functional EGF receptors to an IL3-dependent cell line. Journal of Cellular Physiology. 137: 293-8. PMID 3263970 DOI: 10.1002/Jcp.1041370212 |
0.388 |
|
| 1988 |
Downward J, Weinberg RA. Influence of p21ras on phosphatidylinositol turnover. Cold Spring Harbor Symposia On Quantitative Biology. 53: 883-92. PMID 2908199 DOI: 10.1101/Sqb.1988.053.01.101 |
0.452 |
|
| 1988 |
Downward J, de Gunzburg J, Riehl R, Weinberg RA. p21ras-induced responsiveness of phosphatidylinositol turnover to bradykinin is a receptor number effect. Proceedings of the National Academy of Sciences of the United States of America. 85: 5774-8. PMID 2901087 DOI: 10.1073/Pnas.85.16.5774 |
0.544 |
|
| 1987 |
Berger MS, Greenfield C, Gullick WJ, Haley J, Downward J, Neal DE, Harris AL, Waterfield MD. Evaluation of epidermal growth factor receptors in bladder tumours. British Journal of Cancer. 56: 533-7. PMID 3426916 DOI: 10.1038/Bjc.1987.238 |
0.549 |
|
| 1986 |
Gullick WJ, Downward J, Foulkes JG, Waterfield MD. Antibodies to the ATP-binding site of the human epidermal growth factor (EGF) receptor as specific inhibitors of EGF-stimulated protein-tyrosine kinase activity. European Journal of Biochemistry. 158: 245-53. PMID 3015611 DOI: 10.1111/J.1432-1033.1986.Tb09744.X |
0.593 |
|
| 1985 |
Gullick WJ, Marsden JJ, Downward J, Waterfield MD. The use of anti-synthetic peptide antibodies to study the v-erb B protein from chicken and rat cells transformed by avian erythroblastosis virus Journal of Cell Science. 151-160. PMID 3914991 DOI: 10.1242/Jcs.1985.Supplement_3.15 |
0.543 |
|
| 1985 |
Gullick WJ, Downward J, Parker PJ, Whittle N, Kris R, Schlessinger J, Ullrich A, Waterfield MD. The structure and function of the epidermal growth factor receptor studied by using antisynthetic peptide antibodies. Proceedings of the Royal Society of London. Series B, Biological Sciences. 226: 127-34. PMID 2866520 DOI: 10.1098/Rspb.1985.0087 |
0.554 |
|
| 1985 |
Gullick WJ, Downward J, Waterfield MD. Antibodies to the autophosphorylation sites of the epidermal growth factor receptor protein-tyrosine kinase as probes of structure and function. The Embo Journal. 4: 2869-77. PMID 2415353 DOI: 10.1002/J.1460-2075.1985.Tb04016.X |
0.569 |
|
| 1985 |
Downward J, Waterfield MD, Parker PJ. Autophosphorylation and protein kinase C phosphorylation of the epidermal growth factor receptor. Effect on tyrosine kinase activity and ligand binding affinity. Journal of Biological Chemistry. 260: 14538-14546. DOI: 10.1016/s0021-9258(17)38602-7 |
0.547 |
|
| 1984 |
Downward J, Yarden Y, Mayes E, Scrace G, Totty N, Stockwell P, Ullrich A, Schlessinger J, Waterfield MD. Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences. Nature. 307: 521-7. PMID 6320011 DOI: 10.1038/307521A0 |
0.643 |
|
| 1984 |
Downward J, Parker P, Waterfield MD. Autophosphorylation sites on the epidermal growth factor receptor. Nature. 311: 483-5. PMID 6090945 DOI: 10.1038/311483A0 |
0.597 |
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