| Year |
Citation |
Score |
| 2024 |
Liu G, Kim J, Nguyen NH, Zhou L, Dean A. Long noncoding RNA GATA2AS influences human erythropoiesis by transcription factor and chromatin landscape regulation. Blood. PMID 38447046 DOI: 10.1182/blood.2023021287 |
0.35 |
|
| 2023 |
Xie B, Dean A. Noncoding function of super enhancer derived mRNA in modulating neighboring gene expression and TAD interaction. Biorxiv : the Preprint Server For Biology. PMID 38105946 DOI: 10.1101/2023.12.05.570115 |
0.349 |
|
| 2022 |
Liu G, Wang L, Wess J, Dean A. Enhancer looping protein LDB1 regulates hepatocyte gene expression by cooperating with liver transcription factors. Nucleic Acids Research. PMID 36018801 DOI: 10.1093/nar/gkac707 |
0.356 |
|
| 2022 |
Guo X, Dean A, Zhao Y, Kim J. Hemogen /BRG1 cooperativity modulates promoter and enhancer activation during erythropoiesis. Blood. PMID 35297980 DOI: 10.1182/blood.2021014308 |
0.403 |
|
| 2021 |
Kim J, Dean A. A Zinc Finger Transcription Factor Faithfully Dedicated to Only a Single Target Gene in Erythroid Cells. Molecular Cell. 81: 218-219. PMID 33482089 DOI: 10.1016/j.molcel.2020.12.023 |
0.328 |
|
| 2020 |
Guo X, Plank-Bazinet J, Krivega I, Dale RK, Dean A. Embryonic erythropoiesis and hemoglobin switching require transcriptional repressor ETO2 to modulate chromatin organization. Nucleic Acids Research. PMID 32960220 DOI: 10.1093/Nar/Gkaa736 |
0.516 |
|
| 2020 |
Chambers CB, Gross J, Pratt K, Guo X, Byrnes C, Lee YT, Lavelle D, Dean A, Miller JL, Wilber A. The mRNA-Binding Protein IGF2BP1 Restores Fetal Hemoglobin in Cultured Erythroid Cells from Patients with β-Hemoglobin Disorders. Molecular Therapy. Methods & Clinical Development. 17: 429-440. PMID 32154328 DOI: 10.1016/J.Omtm.2020.01.011 |
0.401 |
|
| 2019 |
Wang H, Kim J, Wang Z, Yan XX, Dean A, Xu W. Crystal structure of human LDB1 in complex with SSBP2. Proceedings of the National Academy of Sciences of the United States of America. PMID 31892537 DOI: 10.2210/Pdb6Tyd/Pdb |
0.386 |
|
| 2019 |
Liu G, Dean A. Enhancer long-range contacts: The multi-adaptor protein LDB1 is the tie that binds. Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms. PMID 31022553 DOI: 10.1016/J.Bbagrm.2019.04.003 |
0.451 |
|
| 2018 |
Guo X, Dean A. CRISPR/Cas9 offers a new tool for studying the role of chromatin architecture in disease pathogenesis. Genome Biology. 19: 185. PMID 30400943 DOI: 10.1186/S13059-018-1569-Z |
0.329 |
|
| 2018 |
Ivaldi MS, Diaz LF, Chakalova L, Lee J, Krivega I, Dean A. Fetal γ-globin genes are regulated by the BGLT3 long non-coding RNA locus. Blood. PMID 30150205 DOI: 10.1182/Blood-2018-07-862003 |
0.486 |
|
| 2018 |
Krivega I, Dean A. Chromosome Conformation Capture (3C and Higher) with Erythroid Samples. Methods in Molecular Biology (Clifton, N.J.). 1698: 237-243. PMID 29076094 DOI: 10.1007/978-1-4939-7428-3_14 |
0.307 |
|
| 2018 |
Krivega I, Dean A. Chromatin Immunoprecipitation (ChIP) with Erythroid Samples. Methods in Molecular Biology (Clifton, N.J.). 1698: 229-236. PMID 29076093 DOI: 10.1007/978-1-4939-7428-3_13 |
0.336 |
|
| 2017 |
Krivega I, Dean A. CTCF fences make good neighbours. Nature Cell Biology. 19: 883-885. PMID 28752854 DOI: 10.1038/Ncb3584 |
0.347 |
|
| 2017 |
Lee J, Krivega I, Dale RK, Dean A. The LDB1 Complex Co-opts CTCF for Erythroid Lineage-Specific Long-Range Enhancer Interactions. Cell Reports. 19: 2490-2502. PMID 28636938 DOI: 10.1016/J.Celrep.2017.05.072 |
0.462 |
|
| 2017 |
Krivega I, Dean A. LDB1-mediated enhancer looping can be established independent of mediator and cohesin. Nucleic Acids Research. 45: 8255-8268. PMID 28520978 DOI: 10.1093/Nar/Gkx433 |
0.485 |
|
| 2016 |
Krivega I, Dean A. Chromatin looping as a target for altering erythroid gene expression. Annals of the New York Academy of Sciences. 1368: 31-9. PMID 26918894 DOI: 10.1111/Nyas.13012 |
0.51 |
|
| 2016 |
Dean A, Lee J, Dale R, Krivega I. New Concepts in Genome Regulation Blood. 128. DOI: 10.1182/Blood.V128.22.Sci-47.Sci-47 |
0.521 |
|
| 2015 |
Krivega I, Byrnes C, de Vasconcellos JF, Lee YT, Kaushal M, Dean A, Miller JL. Inhibition of G9a methyltransferase stimulates fetal hemoglobin production by facilitating LCR/γ-globin looping. Blood. PMID 25979948 DOI: 10.1182/Blood-2015-02-629972 |
0.475 |
|
| 2014 |
Deng W, Rupon JW, Krivega I, Breda L, Motta I, Jahn KS, Reik A, Gregory PD, Rivella S, Dean A, Blobel GA. Reactivation of developmentally silenced globin genes by forced chromatin looping. Cell. 158: 849-60. PMID 25126789 DOI: 10.1016/J.Cell.2014.05.050 |
0.504 |
|
| 2014 |
Plank JL, Dean A. Enhancer function: Mechanistic and genome-wide insights come together Molecular Cell. 55: 5-14. PMID 24996062 DOI: 10.1016/J.Molcel.2014.06.015 |
0.437 |
|
| 2014 |
Krivega I, Dale RK, Dean A. Role of LDB1 in the transition from chromatin looping to transcription activation. Genes & Development. 28: 1278-90. PMID 24874989 DOI: 10.1186/1756-8935-6-S1-P41 |
0.469 |
|
| 2014 |
Yun WJ, Kim YW, Kang Y, Lee J, Dean A, Kim A. The hematopoietic regulator TAL1 is required for chromatin looping between the β-globin LCR and human γ-globin genes to activate transcription. Nucleic Acids Research. 42: 4283-93. PMID 24470145 DOI: 10.1093/nar/gku072 |
0.453 |
|
| 2014 |
Krivega I, Byrnes C, Vasconcellos JFd, Lee YT, Kaushal M, Dean A, Miller JL. Inhibition of G9a Methyltransferase in Adult Human Erythroblasts Stimulates Fetal Hemoglobin Production By Facilitating Looping Between LCR and γ-Globin Gene Blood. 124: 332-332. DOI: 10.1182/Blood.V124.21.332.332 |
0.515 |
|
| 2013 |
Li L, Freudenberg J, Cui K, Dale R, Song SH, Dean A, Zhao K, Jothi R, Love PE. Ldb1-nucleated transcription complexes function as primary mediators of global erythroid gene activation. Blood. 121: 4575-85. PMID 23610375 DOI: 10.1182/Blood-2013-01-479451 |
0.425 |
|
| 2013 |
Pennacchio LA, Bickmore W, Dean A, Nobrega MA, Bejerano G. Enhancers: five essential questions. Nature Reviews. Genetics. 14: 288-95. PMID 23503198 DOI: 10.1038/Nrg3458 |
0.31 |
|
| 2013 |
Rupon JW, Deng W, Wang H, Gregory PD, Reik A, Dean A, Blobel GA. Using Forced Chromatin Looping To Overcome Developmental Silencing Of Embryonic and Fetal β-Type Globin Genes In Adult Erythroid Cells Blood. 122: 433-433. DOI: 10.1182/Blood.V122.21.433.433 |
0.529 |
|
| 2013 |
Dean A. Functional organization of β-globin locus chromatin loop over long distances Experimental Hematology. 41. DOI: 10.1016/J.Exphem.2013.05.030 |
0.323 |
|
| 2012 |
Junier I, Dale RK, Hou C, Képès F, Dean A. CTCF-mediated transcriptional regulation through cell type-specific chromosome organization in the β-globin locus. Nucleic Acids Research. 40: 7718-27. PMID 22705794 DOI: 10.1093/Nar/Gks536 |
0.515 |
|
| 2012 |
Deng W, Lee J, Wang H, Miller J, Reik A, Gregory PD, Dean A, Blobel GA. Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor. Cell. 149: 1233-44. PMID 22682246 DOI: 10.1016/J.Cell.2012.03.051 |
0.452 |
|
| 2012 |
Kim A, Dean A. Chromatin loop formation in the β-globin locus and its role in globin gene transcription. Molecules and Cells. 34: 1-5. PMID 22610406 DOI: 10.1007/S10059-012-0048-8 |
0.511 |
|
| 2012 |
Song SH, Kim A, Dale R, Dean A. Ldb1 regulates carbonic anhydrase 1 during erythroid differentiation. Biochimica Et Biophysica Acta. 1819: 885-91. PMID 22609543 DOI: 10.1016/J.Bbagrm.2012.05.001 |
0.451 |
|
| 2012 |
Bender MA, Ragoczy T, Lee J, Byron R, Telling A, Dean A, Groudine M. The hypersensitive sites of the murine β-globin locus control region act independently to affect nuclear localization and transcriptional elongation. Blood. 119: 3820-7. PMID 22378846 DOI: 10.1182/Blood-2011-09-380485 |
0.464 |
|
| 2012 |
Kiefer CM, Dean A. Monitoring the effects of chromatin remodelers on long-range interactions in vivo. Methods in Molecular Biology (Clifton, N.J.). 833: 29-45. PMID 22183586 DOI: 10.1007/978-1-61779-477-3_3 |
0.426 |
|
| 2012 |
Krivega I, Dean A. Enhancer and promoter interactions-long distance calls. Current Opinion in Genetics & Development. 22: 79-85. PMID 22169023 DOI: 10.1016/J.Gde.2011.11.001 |
0.445 |
|
| 2011 |
Kiefer CM, Lee J, Hou C, Dale RK, Lee YT, Meier ER, Miller JL, Dean A. Distinct Ldb1/NLI complexes orchestrate γ-globin repression and reactivation through ETO2 in human adult erythroid cells. Blood. 118: 6200-8. PMID 22010104 DOI: 10.1182/Blood-2011-06-363101 |
0.487 |
|
| 2011 |
Krivega M, Dean A. Insulators organize chromatin: emerging rules of the game. Molecular Cell. 44: 1-2. PMID 21981911 DOI: 10.1016/J.Molcel.2011.09.009 |
0.326 |
|
| 2011 |
Lienert F, Wirbelauer C, Som I, Dean A, Mohn F, Schübeler D. Identification of genetic elements that autonomously determine DNA methylation states. Nature Genetics. 43: 1091-7. PMID 21964573 DOI: 10.1038/Ng.946 |
0.323 |
|
| 2011 |
Dean A. In the loop: long range chromatin interactions and gene regulation. Briefings in Functional Genomics. 10: 3-10. PMID 21258045 DOI: 10.1093/Bfgp/Elq033 |
0.437 |
|
| 2010 |
Li L, Lee JY, Gross J, Song SH, Dean A, Love PE. A requirement for Lim domain binding protein 1 in erythropoiesis. The Journal of Experimental Medicine. 207: 2543-50. PMID 21041453 DOI: 10.1084/Jem.20100504 |
0.397 |
|
| 2010 |
Song SH, Kim A, Ragoczy T, Bender MA, Groudine M, Dean A. Multiple functions of Ldb1 required for beta-globin activation during erythroid differentiation. Blood. 116: 2356-64. PMID 20570862 DOI: 10.1182/Blood-2010-03-272252 |
0.51 |
|
| 2010 |
Hou C, Dale R, Dean A. Cell type specificity of chromatin organization mediated by CTCF and cohesin. Proceedings of the National Academy of Sciences of the United States of America. 107: 3651-6. PMID 20133600 DOI: 10.1073/Pnas.0912087107 |
0.48 |
|
| 2009 |
Sripichai O, Kiefer CM, Bhanu NV, Tanno T, Noh SJ, Goh SH, Russell JE, Rognerud CL, Ou CN, Oneal PA, Meier ER, Gantt NM, Byrnes C, Lee YT, Dean A, et al. Cytokine-mediated increases in fetal hemoglobin are associated with globin gene histone modification and transcription factor reprogramming. Blood. 114: 2299-306. PMID 19597182 DOI: 10.1182/Blood-2009-05-219386 |
0.496 |
|
| 2009 |
Bhatia H, Hallock JL, Dutta A, Karkashon S, Sterner LS, Miyazaki T, Dean A, Little JA. Short-chain fatty acid-mediated effects on erythropoiesis in primary definitive erythroid cells. Blood. 113: 6440-8. PMID 19380871 DOI: 10.1182/Blood-2008-09-171728 |
0.668 |
|
| 2009 |
Kim SI, Bultman SJ, Kiefer CM, Dean A, Bresnick EH. BRG1 requirement for long-range interaction of a locus control region with a downstream promoter. Proceedings of the National Academy of Sciences of the United States of America. 106: 2259-64. PMID 19171905 DOI: 10.1073/Pnas.0806420106 |
0.436 |
|
| 2009 |
Sripichai O, Kiefer CM, Lee YT, Meier ER, Byrnes C, Dean A, Miller JL. During Terminal Differentiation, HbF-Inducing Cytokines Cause Decreased Expression and Reduced Globin Locus Occupancy of BCL11A in Human Erythroblasts. Blood. 114: 457-457. DOI: 10.1182/Blood.V114.22.457.457 |
0.448 |
|
| 2008 |
Hou C, Zhao H, Tanimoto K, Dean A. CTCF-dependent enhancer-blocking by alternative chromatin loop formation. Proceedings of the National Academy of Sciences of the United States of America. 105: 20398-403. PMID 19074263 DOI: 10.1073/Pnas.0808506106 |
0.442 |
|
| 2008 |
Kiefer CM, Hou C, Little JA, Dean A. Epigenetics of beta-globin gene regulation. Mutation Research. 647: 68-76. PMID 18760288 DOI: 10.1016/J.Mrfmmm.2008.07.014 |
0.665 |
|
| 2008 |
Cho Y, Song SH, Lee JJ, Choi N, Kim CG, Dean A, Kim A. The role of transcriptional activator GATA-1 at human beta-globin HS2. Nucleic Acids Research. 36: 4521-8. PMID 18586828 DOI: 10.1093/nar/gkn368 |
0.368 |
|
| 2008 |
Bhatia H, Hallock JL, Sterner LE, Karkashon S, Dutta A, Miyazaki T, Dean A, Little J. A Novel Model of Short Chain Fatty Acid (SCFA)- Mediated up-Regulation of Embryonic/Fetal Globin Genes during Definitive Erythropoiesis. Blood. 112: 1878-1878. DOI: 10.1182/Blood.V112.11.1878.1878 |
0.63 |
|
| 2007 |
Song SH, Hou C, Dean A. A positive role for NLI/Ldb1 in long-range beta-globin locus control region function. Molecular Cell. 28: 810-22. PMID 18082606 DOI: 10.1016/J.Molcel.2007.09.025 |
0.488 |
|
| 2007 |
Kim A, Song SH, Brand M, Dean A. Nucleosome and transcription activator antagonism at human beta-globin locus control region DNase I hypersensitive sites. Nucleic Acids Research. 35: 5831-8. PMID 17720709 DOI: 10.1093/nar/gkm620 |
0.36 |
|
| 2007 |
Kim A, Zhao H, Ifrim I, Dean A. Beta-globin intergenic transcription and histone acetylation dependent on an enhancer. Molecular and Cellular Biology. 27: 2980-6. PMID 17283048 DOI: 10.1128/Mcb.02337-06 |
0.466 |
|
| 2007 |
Kim A, Kiefer CM, Dean A. Distinctive signatures of histone methylation in transcribed coding and noncoding human beta-globin sequences. Molecular and Cellular Biology. 27: 1271-9. PMID 17158930 DOI: 10.1128/Mcb.01684-06 |
0.414 |
|
| 2007 |
Bhatia H, Hallock J, Sterner L, Miyazaki T, Dean A, Little J. Endogenous Elevations of Short Chain Fatty Acids (SCFAs) Can Up-Regulate Embryonic Globin Gene Expression. Blood. 110: 1770-1770. DOI: 10.1182/Blood.V110.11.1770.1770 |
0.643 |
|
| 2007 |
Kim A, Kiefer CM, Dean A. Chromatin structure and epigenetic modification in the human β-globin locus Blood Cells Molecules and Diseases. 38: 135. DOI: 10.1016/J.Bcmd.2006.10.038 |
0.354 |
|
| 2006 |
Zhao H, Kim A, Song SH, Dean A. Enhancer blocking by chicken beta-globin 5'-HS4: role of enhancer strength and insulator nucleosome depletion. The Journal of Biological Chemistry. 281: 30573-80. PMID 16877759 DOI: 10.1074/Jbc.M606803200 |
0.466 |
|
| 2006 |
Dean A. On a chromosome far, far away: LCRs and gene expression. Trends in Genetics : Tig. 22: 38-45. PMID 16309780 DOI: 10.1016/J.Tig.2005.11.001 |
0.497 |
|
| 2004 |
Zhao H, Dean A. An insulator blocks spreading of histone acetylation and interferes with RNA polymerase II transfer between an enhancer and gene. Nucleic Acids Research. 32: 4903-19. PMID 15371553 DOI: 10.1093/Nar/Gkh832 |
0.475 |
|
| 2004 |
Dean A. Chromatin remodelling and the interaction between enhancers and promoters in the beta-globin locus. Briefings in Functional Genomics & Proteomics. 2: 344-54. PMID 15163369 DOI: 10.1093/bfgp/2.4.344 |
0.353 |
|
| 2004 |
Kim A, Dean A. Developmental stage differences in chromatin subdomains of the beta-globin locus. Proceedings of the National Academy of Sciences of the United States of America. 101: 7028-33. PMID 15105444 DOI: 10.1073/Pnas.0307985101 |
0.512 |
|
| 2004 |
Sterner L, Miyazaki T, Swift L, Dean A, Little J. Endogenous Elevations of Short Chain Fatty Acids Up-Regulate Embryonic Globin Gene Expression during Primitive Erythropoiesis. Blood. 104: 1210-1210. DOI: 10.1182/Blood.V104.11.1210.1210 |
0.641 |
|
| 2003 |
Kim A, Dean A. A human globin enhancer causes both discrete and widespread alterations in chromatin structure. Molecular and Cellular Biology. 23: 8099-109. PMID 14585970 DOI: 10.1128/Mcb.23.22.8099-8109.2003 |
0.443 |
|
| 2003 |
Gui Cy, Dean A. A major role for the TATA box in recruitment of chromatin modifying complexes to a globin gene promoter Proceedings of the National Academy of Sciences of the United States of America. 100: 7009-7014. PMID 12773626 DOI: 10.1073/Pnas.1236499100 |
0.46 |
|
| 2003 |
Jackson DA, McDowell JC, Dean A. Beta-globin locus control region HS2 and HS3 interact structurally and functionally. Nucleic Acids Research. 31: 1180-90. PMID 12582237 DOI: 10.1093/Nar/Gkg217 |
0.458 |
|
| 2001 |
Gui CY, Dean A. Acetylation of a specific promoter nucleosome accompanies activation of the ε-globin gene by β-globin locus control region HS2 Molecular and Cellular Biology. 21: 1155-1163. PMID 11158302 DOI: 10.1128/Mcb.21.4.1155-1163.2001 |
0.394 |
|
| 1999 |
McDowell JC, Dean A. Structural and Functional Cross-Talk between a Distant Enhancer and the ɛ-Globin Gene Promoter Shows Interdependence of the Two Elements in Chromatin Molecular and Cellular Biology. 19: 7600-7609. PMID 10523648 DOI: 10.1128/Mcb.19.11.7600 |
0.53 |
|
| 1996 |
Gong QH, McDowell JC, Dean A. Essential role of NF-E2 in remodeling of chromatin structure and transcriptional activation of the epsilon-globin gene in vivo by 5' hypersensitive site 2 of the beta-globin locus control region. Molecular and Cellular Biology. 16: 6055-64. PMID 8887635 DOI: 10.1128/MCB.16.11.6055 |
0.431 |
|
| 1993 |
Gong Q, Dean A. Enhancer-Dependent Transcription of the ε-Globin Promoter Requires Promoter-Bound GATA-1 and Enhancer-Bound AP-1/NF-E2 Molecular and Cellular Biology. 13: 911-917. PMID 8423810 DOI: 10.1128/Mcb.13.2.911 |
0.409 |
|
| 1991 |
Gong Q, Stern J, Dean A. Transcriptional role of a conserved GATA-1 site in the human epsilon-globin gene promoter. Molecular and Cellular Biology. 11: 2558-2566. PMID 2017165 DOI: 10.1128/Mcb.11.5.2558 |
0.479 |
|
| 1989 |
Dean A, Pederson DS, Simpson RT. Isolation of yeast plasmid chromatin. Methods in Enzymology. 170: 26-41. PMID 2671602 DOI: 10.1016/0076-6879(89)70041-0 |
0.334 |
|
| 1984 |
Fordis CM, Anagnou NP, Dean A, Nienhuis AW, Schechter AN. A beta-globin gene, inactive in the K562 leukemic cell, functions normally in a heterologous expression system Proceedings of the National Academy of Sciences of the United States of America. 81: 4485-4489. PMID 6205398 DOI: 10.1073/Pnas.81.14.4485 |
0.564 |
|
| 1984 |
Wu Y, Dean A, Egan W, Schechter AN. Control of oxygen affinity of hemoglobin in K562 cells induced by hemin. Blood. 63: 1447-1452. DOI: 10.1182/Blood.V63.6.1447.1447 |
0.523 |
|
| 1983 |
Dean A, Ley TJ, Humphries RK, Fordis M, Schechter AN. Inducible transcription of five globin genes in K562 human leukemia cells Proceedings of the National Academy of Sciences of the United States of America. 80: 5515-5519. PMID 6310580 DOI: 10.1073/Pnas.80.18.5515 |
0.56 |
|
| 1983 |
Klausner RD, Van Renswoude J, Ashwell G, Kempf C, Schechter AN, Dean A, Bridges KR. Receptor-mediated endocytosis of transferrin in K562 cells. Journal of Biological Chemistry. 258: 4715-4724. DOI: 10.1016/s0021-9258(18)32481-5 |
0.418 |
|
| 1981 |
Dean A, Erard F, Schneider AB, Schechter AN. Induction of hemoglobin accumulation in human K562 cells by hemin is reversible Science. 212: 459-461. PMID 6163216 DOI: 10.1126/Science.6163216 |
0.532 |
|
| 1981 |
Erard F, Dean A, Schechter A. Inhibitors of cell division reversibly modify hemoglobin concentration in human erythroleukemia K562 cells Blood. 58: 1236-1239. DOI: 10.1182/Blood.V58.6.1236.Bloodjournal5861236 |
0.552 |
|
| 1981 |
Dean A, Schechter A, Papayannopoulou T, Stamatoyannopoulos G. Heterogeneity of erythroid precursor cells. Hemoglobin quantitation in single clones by radioimmunoassay. Journal of Biological Chemistry. 256: 2447-2453. DOI: 10.1016/s0021-9258(19)69801-7 |
0.451 |
|
| 1980 |
Alston K, Dean A, Schechter AN. The immunochemical effects of metal substitution in the prosthetic group of hemoglobin. Molecular Immunology. 17: 1475-85. PMID 6170875 DOI: 10.1016/0161-5890(80)90173-X |
0.44 |
|
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