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Kanji Nakatsu - Publications

Affiliations: 
1973-2017 Pharmacology and Toxicology Queen's University, Canada, Kingston, Ontario, Canada 
Area:
Pharmacology, Biochemistry
Website:
https://www.researchgate.net/profile/Kanji_Nakatsu
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66 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Vukomanovic D, Jia Z, Nakatsu K, Smith GN, Ozolinš TRS. Riboflavin and pyrroloquinoline quinone generate carbon monoxide in the presence of tissue microsomes or recombinant human cytochrome P-450 oxidoreductase (CPR); implications for possible roles in gasotransmission. Canadian Journal of Physiology and Pharmacology. PMID 31825651 DOI: 10.1139/Cjpp-2019-0376  0.337
2018 Rahman MN, Vukomanovic D, Vlahakis JZ, Szarek WA, Nakatsu K, Jia Z. Structural Insights into Azole-based Inhibitors of Heme Oxygenase-1: Development of Selective Compounds for Therapeutic Applications. Current Medicinal Chemistry. PMID 30674243 DOI: 10.2174/0929867325666180606082512  0.355
2017 Hum M, McLaughlin BE, Kong X, Vlahakis JZ, Vukomanovic D, Szarek WA, Nakatsu K. Differential inhibition of rat and mouse microsome heme oxygenase by derivatives of imidazole and benzimidazole. Canadian Journal of Physiology and Pharmacology. PMID 28793202 DOI: 10.1139/Cjpp-2017-0236  0.386
2017 Vukomanovic D, Rahman MN, Jia Z, Nakatsu K. Drug-enhanced carbon monoxide production from heme by cytochrome P450 reductase. Medical Gas Research. 7: 37-44. PMID 28480030 DOI: 10.4103/2045-9912.202908  0.328
2016 Vukomanovic D, Rahman MN, Maines MD, Ozolinš TR, Szarek WA, Jia Z, Nakatsu K. Cysteine-independent activation/inhibition of heme oxygenase-2. Medical Gas Research. 6: 10-13. PMID 27826418 DOI: 10.4103/2045-9912.179341  0.396
2015 Kong X, Vukomanovic D, Nakatsu K, Szarek WA. Structure-Activity Relationships of 1,2-Disubstituted Benzimidazoles: Selective Inhibition of Heme Oxygenase-2 Activity. Chemmedchem. 10: 1435-41. PMID 26083133 DOI: 10.1002/Cmdc.201500128  0.341
2014 Vukomanovic D, Rahman MN, Bilokin Y, Golub AG, Brien JF, Szarek WA, Jia Z, Nakatsu K. In vitro Activation of heme oxygenase-2 by menadione and its analogs. Medical Gas Research. 4: 4. PMID 24533775 DOI: 10.1186/2045-9912-4-4  0.356
2014 Rahman M, Vukomanovic D, Vlahakis J, Szarek W, Nakatsu K, Jia Z. Structural insights into heme oxygenase-1 inhibition by azole-based compounds Acta Crystallographica Section a Foundations and Advances. 70: C831-C831. DOI: 10.1107/S2053273314091682  0.36
2013 Vlahakis JZ, Vukomanovic D, Nakatsu K, Szarek WA. Selective inhibition of heme oxygenase-2 activity by analogs of 1-(4-chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzimidazole (clemizole): Exploration of the effects of substituents at the N-1 position. Bioorganic & Medicinal Chemistry. 21: 6788-95. PMID 24021581 DOI: 10.1016/J.Bmc.2013.07.050  0.381
2013 Rahman MN, Vukomanovic D, Vlahakis JZ, Szarek WA, Nakatsu K, Jia Z. Structural insights into human heme oxygenase-1 inhibition by potent and selective azole-based compounds. J R Soc Interface. 10: 20120697. PMID 23097500 DOI: 10.1098/Rsif.2012.0697  0.363
2012 Vlahakis JZ, Lazar C, Roman G, Vukomanovic D, Nakatsu K, Szarek WA. Heme oxygenase inhibition by α-(1H-imidazol-1-yl)-ω-phenylalkanes: effect of introduction of heteroatoms in the alkyl linker. Chemmedchem. 7: 897-902. PMID 22431362 DOI: 10.1002/Cmdc.201100602  0.332
2012 Rahman MN, Vlahakis JZ, Vukomanovic D, Lee W, Szarek WA, Nakatsu K, Jia Z. A novel, "double-clamp" binding mode for human heme oxygenase-1 inhibition. Plos One. 7: e29514. PMID 22276118 DOI: 10.1371/Journal.Pone.0029514  0.33
2011 Vukomanovic D, McLaughlin BE, Rahman MN, Szarek WA, Brien JF, Jia Z, Nakatsu K. Selective activation of heme oxygenase-2 by menadione. Canadian Journal of Physiology and Pharmacology. PMID 22039914 DOI: 10.1139/Y11-091  0.38
2011 Vlahakis JZ, Rahman MN, Roman G, Jia Z, Nakatsu K, Szarek WA. Rapid, convenient method for screening imidazole-containing compounds for heme oxygenase inhibition. Journal of Pharmacological and Toxicological Methods. 63: 79-88. PMID 20561893 DOI: 10.1016/J.Vascn.2010.05.015  0.32
2010 Roman G, Vlahakis JZ, Vukomanovic D, Nakatsu K, Szarek WA. Heme oxygenase inhibition by 1-aryl-2-(1h-imidazol-1-yl/1h-1,2,4-triazol-1-yl)ethanones and their derivatives. Chemmedchem. 5: 1541-55. PMID 20652928 DOI: 10.1002/Cmdc.201000120  0.357
2010 Hum M, McLaughlin BE, Roman G, Vlahakis JZ, Szarek WA, Nakatsu K. The effects of azole-based heme oxygenase inhibitors on rat cytochromes P450 2E1 and 3A1/2 and human cytochromes P450 3A4 and 2D6. The Journal of Pharmacology and Experimental Therapeutics. 334: 981-7. PMID 20501634 DOI: 10.1124/Jpet.110.168492  0.368
2010 Bourque SL, Benjamin CD, Adams MA, Nakatsu K. Lack of hemodynamic effects after extended heme synthesis inhibition by succinylacetone in rats. The Journal of Pharmacology and Experimental Therapeutics. 333: 290-6. PMID 20071481 DOI: 10.1124/Jpet.109.162966  0.358
2010 Roman G, Rahman MN, Vukomanovic D, Jia Z, Nakatsu K, Szarek WA. Heme oxygenase inhibition by 2-oxy-substituted 1-azolyl-4-phenylbutanes: effect of variation of the azole moiety. X-ray crystal structure of human heme oxygenase-1 in complex with 4-phenyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone. Chemical Biology & Drug Design. 75: 68-90. PMID 19954435 DOI: 10.1111/J.1747-0285.2009.00909.X  0.336
2010 Rahman MN, Vlahakis JZ, Roman G, Vukomanovic D, Szarek WA, Nakatsu K, Jia Z. Structural characterization of human heme oxygenase-1 in complex with azole-based inhibitors. Journal of Inorganic Biochemistry. 104: 324-30. PMID 19917515 DOI: 10.1016/J.Jinorgbio.2009.10.011  0.329
2009 Rahman MN, Vlahakis JZ, Vukomanovic D, Szarek WA, Nakatsu K, Jia Z. X-ray crystal structure of human heme oxygenase-1 with (2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4[((5-trifluoromethylpyridin-2-yl)thio)methyl]-1,3-dioxolane: a novel, inducible binding mode. Journal of Medicinal Chemistry. 52: 4946-50. PMID 19601578 DOI: 10.1021/Jm900434F  0.305
2009 Vlahakis JZ, Hum M, Rahman MN, Jia Z, Nakatsu K, Szarek WA. Synthesis and evaluation of imidazole-dioxolane compounds as selective heme oxygenase inhibitors: effect of substituents at the 4-position of the dioxolane ring. Bioorganic & Medicinal Chemistry. 17: 2461-75. PMID 19268600 DOI: 10.1016/J.Bmc.2009.01.078  0.314
2008 Rahman MN, Vlahakis JZ, Szarek WA, Nakatsu K, Jia Z. X-ray crystal structure of human heme oxygenase-1 in complex with 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone: a common binding mode for imidazole-based heme oxygenase-1 inhibitors. Journal of Medicinal Chemistry. 51: 5943-52. PMID 18798608 DOI: 10.1021/Jm800505M  0.308
2007 Kinobe RT, Ji Y, Vlahakis JZ, Motterlini R, Brien JF, Szarek WA, Nakatsu K. Effectiveness of novel imidazole-dioxolane heme oxygenase inhibitors in renal proximal tubule epithelial cells. The Journal of Pharmacology and Experimental Therapeutics. 323: 763-70. PMID 17761847 DOI: 10.1124/Jpet.107.119800  0.386
2007 Roman G, Riley JG, Vlahakis JZ, Kinobe RT, Brien JF, Nakatsu K, Szarek WA. Heme oxygenase inhibition by 2-oxy-substituted 1-(1H-imidazol-1-yl)-4-phenylbutanes: effect of halogen substitution in the phenyl ring. Bioorganic & Medicinal Chemistry. 15: 3225-34. PMID 17339115 DOI: 10.1016/J.Bmc.2007.02.034  0.32
2006 Vlahakis JZ, Kinobe RT, Bowers RJ, Brien JF, Nakatsu K, Szarek WA. Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors. Journal of Medicinal Chemistry. 49: 4437-41. PMID 16821802 DOI: 10.1021/Jm0511435  0.331
2006 Kinobe RT, Dercho RA, Vlahakis JZ, Brien JF, Szarek WA, Nakatsu K. Inhibition of the enzymatic activity of heme oxygenases by azole-based antifungal drugs. The Journal of Pharmacology and Experimental Therapeutics. 319: 277-84. PMID 16807364 DOI: 10.1124/Jpet.106.102699  0.348
2006 Dercho RA, Nakatsu K, Wong RJ, Stevenson DK, Vreman HJ. Determination of in vivo carbon monoxide production in laboratory animals via exhaled air. Journal of Pharmacological and Toxicological Methods. 54: 288-95. PMID 16540352 DOI: 10.1016/J.Vascn.2006.01.004  0.3
2006 Vlahakis JZ, Kinobe RT, Nakatsu K, Szarek WA, Crandall IE. Anti-Plasmodium activity of imidazole-dioxolane compounds. Bioorganic & Medicinal Chemistry Letters. 16: 2396-406. PMID 16495054 DOI: 10.1016/J.Bmcl.2006.01.122  0.306
2006 Kinobe RT, Vlahakis JZ, Vreman HJ, Stevenson DK, Brien JF, Szarek WA, Nakatsu K. Selectivity of imidazole-dioxolane compounds for in vitro inhibition of microsomal haem oxygenase isoforms. British Journal of Pharmacology. 147: 307-15. PMID 16331285 DOI: 10.1038/Sj.Bjp.0706555  0.431
2005 Vlahakis JZ, Kinobe RT, Bowers RJ, Brien JF, Nakatsu K, Szarek WA. Synthesis and evaluation of azalanstat analogues as heme oxygenase inhibitors. Bioorganic & Medicinal Chemistry Letters. 15: 1457-61. PMID 15713406 DOI: 10.1016/J.Bmcl.2004.12.075  0.355
2004 Kinobe R, Ji Y, Nakatsu K. Peroxynitrite-mediated inactivation of heme oxygenases. Bmc Pharmacology. 4: 26. PMID 15498099 DOI: 10.1186/1471-2210-4-26  0.42
2004 Jaronczyk K, Bui L, Soong JM, McLaughlin BE, Marks GS, Brien JF, Nakatsu K. The source of heme for vascular heme oxygenase II: de novo heme biosynthesis in rat aorta. Canadian Journal of Physiology and Pharmacology. 82: 218-24. PMID 15181459 DOI: 10.1139/Y04-015  0.399
2004 Bui L, Rish K, Jaronczyk K, Bourque S, McLaughlin BE, Brien JF, Marks GS, Smith A, Nakatsu K. The source of heme for vascular heme oxygenase I: heme uptake in rat aorta. Canadian Journal of Physiology and Pharmacology. 82: 209-17. PMID 15181458 DOI: 10.1139/Y04-014  0.376
2003 Appleton SD, Lash GE, Marks GS, Nakatsu K, Brien JF, Smith GN, Graham CH. Effect of glucose and oxygen deprivation on heme oxygenase expression in human chorionic villi explants and immortalized trophoblast cells. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 285: R1453-60. PMID 14615405 DOI: 10.1152/Ajpregu.00234.2003  0.732
2003 McLaughlin BE, Lash GE, Smith GN, Marks GS, Nakatsu K, Graham CH, Brien JF. Heme oxygenase expression in selected regions of term human placenta. Experimental Biology and Medicine (Maywood, N.J.). 228: 564-7. PMID 12709587 DOI: 10.1177/15353702-0322805-28  0.38
2003 Appleton SD, Marks GS, Nakatsu K, Brien JF, Smith GN, Graham CH, Lash GE. Effects of hypoxia on heme oxygenase expression in human chorionic villi explants and immortalized trophoblast cells. American Journal of Physiology. Heart and Circulatory Physiology. 284: H853-8. PMID 12578814 DOI: 10.1152/Ajpheart.00655.2002  0.727
2003 Gamble JT, Nakatsu K, Marks GS. Comparison of the formation of N-alkylprotoporphyrin IX after interaction of porphyrinogenic xenobiotics with single cDNA-expressed human P450 enzymes in microsomes prepared from baculovirus-infected insect cells and human lymphoblastoid cell lines. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 202-5. PMID 12527701 DOI: 10.1124/Dmd.31.2.202  0.302
2003 Lash GE, McLaughlin BE, MacDonald-Goodfellow SK, Smith GN, Brien JF, Marks GS, Nakatsu K, Graham CH. Relationship between tissue damage and heme oxygenase expression in chorionic villi of term human placenta. American Journal of Physiology. Heart and Circulatory Physiology. 284: H160-7. PMID 12388278 DOI: 10.1152/Ajpheart.00738.2002  0.352
2002 Gamble JT, Nakatsu K, Marks GS. Porphyrinogenic xenobiotic-induced N-alkylprotoporphyrin IX formation: a bioassay utilizing chick embryo hepatic ferrochelatase. Journal of Pharmacological and Toxicological Methods. 47: 25-32. PMID 12387936 DOI: 10.1016/S1056-8719(02)00190-9  0.31
2002 Bainbridge SA, Farley AE, McLaughlin BE, Graham CH, Marks GS, Nakatsu K, Brien JF, Smith GN. Carbon monoxide decreases perfusion pressure in isolated human placenta. Placenta. 23: 563-9. PMID 12361675 DOI: 10.1053/Plac.2002.0845  0.329
2002 Hosein S, Marks GS, Brien JF, McLaughlin BE, Nakatsu K. An extracellular source of heme can induce a significant heme oxygenase mediated relaxation in the rat aorta. Canadian Journal of Physiology and Pharmacology. 80: 761-5. PMID 12269785 DOI: 10.1139/Y02-086  0.366
2002 Marks GS, Vreman HJ, McLaughlin BE, Brien JF, Nakatsu K. Measurement of endogenous carbon monoxide formation in biological systems. Antioxidants & Redox Signaling. 4: 271-7. PMID 12006178 DOI: 10.1089/152308602753666325  0.31
2002 Appleton SD, Marks GS, Nakatsu K, Brien JF, Smith GN, Graham CH. Heme oxygenase activity in placenta: direct dependence on oxygen availability. American Journal of Physiology. Heart and Circulatory Physiology. 282: H2055-9. PMID 12003811 DOI: 10.1152/Ajpheart.01084.2001  0.733
2001 McLaughlin BE, Lash GE, Graham CH, Smith GN, Vreman HJ, Stevenson DK, Marks GS, Nakatsu K, Brien JF. Endogenous carbon monoxide formation by chorionic villi of term human placenta. Placenta. 22: 886-8. PMID 11718578 DOI: 10.1053/Plac.2001.0729  0.326
2000 McLaughlin BE, Hutchinson JM, Graham CH, Smith GN, Marks GS, Nakatsu K, Brien JF. Heme oxygenase activity in term human placenta. Placenta. 21: 870-3. PMID 11095937 DOI: 10.1053/Plac.2000.0574  0.42
2000 McLaughlin BE, Chretien ML, Choi C, Brien JF, Nakatsu K, Marks GS. Potentiation of carbon monoxide-induced relaxation of rat aorta by YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole] Canadian Journal of Physiology and Pharmacology. 78: 343-349. DOI: 10.1139/Y99-145  0.391
1999 Appleton SD, Chretien ML, McLaughlin BE, Vreman HJ, Stevenson DK, Brien JF, Nakatsu K, Maurice DH, Marks GS. Selective inhibition of heme oxygenase, without inhibition of nitric oxide synthase or soluble guanylyl cyclase, by metalloporphyrins at low concentrations. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 27: 1214-9. PMID 10497150  0.732
1998 Odrcich MJ, Graham CH, Kimura KA, McLaughlin BE, Marks GS, Nakatsu K, Brien JF. Heme oxygenase and nitric oxide synthase in the placenta of the guinea-pig during gestation. Placenta. 19: 509-16. PMID 9778124 DOI: 10.1016/S0143-4004(98)91044-X  0.402
1997 Marks GS, McLaughlin BE, Vreman HJ, Stevenson DK, Nakatsu K, Brien JF, Pang SC. Heme oxygenase activity and immunohistochemical localization in bovine pulmonary artery and vein. Journal of Cardiovascular Pharmacology. 30: 1-6. PMID 9268214 DOI: 10.1097/00005344-199707000-00001  0.395
1997 Cook MN, Marks GS, Vreman HJ, Nakatsu K, Stevenson DK, Brien JF. Ontogeny of heme oxygenase activity in the hippocampus, frontal cerebral cortex, and cerebellum of the guinea pig. Brain Research. Developmental Brain Research. 92: 18-23. PMID 8861718 DOI: 10.1016/0165-3806(95)00194-8  0.351
1995 Liu ZG, McLaughlin BE, Marks GS, Brien JF, Nakatsu K. Sulfhydryl involvement in nitric oxide sequestration and nitric oxide induced guanylyl cyclase activation in vascular smooth muscle. Canadian Journal of Physiology and Pharmacology. 73: 1144-8. PMID 8564882 DOI: 10.1139/Y95-163  0.341
1995 Hussain AS, Poklewska-Koziell M, Brien JF, Marks GS, Nakatsu K. Nitric oxide formation from glyceryl trinitrate by rabbit aortic strip: detection by rabbit taenia coli concurrent with vasorelaxation. British Journal of Pharmacology. 113: 1508-14. PMID 7889309 DOI: 10.1111/J.1476-5381.1994.Tb17167.X  0.302
1995 Bozinovski J, Brien JF, Marks GS, Nakatsu K. Inhibition of nitrovasodilators by pyocyanin and methylene blue is dissociated from nitric oxide formation. Canadian Journal of Physiology and Pharmacology. 72: 746-52. PMID 7828082 DOI: 10.1139/Y94-106  0.362
1995 Cook MN, Nakatsu K, Marks GS, McLaughlin BE, Vreman HJ, Stevenson DK, Brien JF. Heme oxygenase activity in the adult rat aorta and liver as measured by carbon monoxide formation. Canadian Journal of Physiology and Pharmacology. 73: 515-8. PMID 7671194 DOI: 10.1139/Y95-065  0.38
1993 Liu L, Nakatsu K, Massey TE. In vitro cytochrome P450 monooxygenase and prostaglandin H-synthase mediated aflatoxin B1 biotransformation in guinea pig tissues: effects of beta-naphthoflavone treatment. Archives of Toxicology. 67: 379-85. PMID 8215906 DOI: 10.1007/Bf01977398  0.318
1993 Beaton ED, Liu Z, McLaughlin BE, Brien JF, Nakatsu K, Marks GS. A novel method for detection of nitric oxide binding sites by using a chemiluminescence-headspace gas technique. Journal of Pharmacological and Toxicological Methods. 30: 217-22. PMID 8123903 DOI: 10.1016/1056-8719(93)90020-F  0.305
1992 Liu Z, Brien JF, Marks GS, McLaughlin BE, Nakatsu K. Carbon monoxide does not inhibit glyceryl trinitrate biotransformation by or relaxation of aorta. European Journal of Pharmacology. 211: 129-32. PMID 1618261 DOI: 10.1016/0014-2999(92)90275-9  0.3
1992 Marks GS, McLaughlin BE, Nakatsu K, Brien JF. Direct evidence for nitric oxide formation from glyceryl trinitrate during incubation with intact bovine pulmonary artery. Canadian Journal of Physiology and Pharmacology. 70: 308-11. PMID 1521184 DOI: 10.1139/Y92-039  0.333
1992 Marks GS, McLaughlin BE, Nakatsu K, Brien JF. Biotransformation of glyceryl trinitrate by rat brain homogenate. Canadian Journal of Physiology and Pharmacology. 70: 935-7. PMID 1423038 DOI: 10.1139/Y92-127  0.336
1991 Marks GS, McLaughlin BE, Brown LB, Beaton DE, Booth BP, Nakatsu K, Brien JF. Interaction of glyceryl trinitrate and sodium nitroprusside with bovine pulmonary vein homogenate and 10,000 x g supernatant: biotransformation and nitric oxide formation. Canadian Journal of Physiology and Pharmacology. 69: 889-92. PMID 1913335 DOI: 10.1139/Y91-135  0.322
1991 Brien JF, McLaughlin BE, Nakatsu K, Marks GS. Quantitation of nitric oxide formation from nitrovasodilator drugs by chemiluminescence analysis of headspace gas. Journal of Pharmacological Methods. 25: 19-27. PMID 1903171 DOI: 10.1016/0160-5402(91)90019-2  0.309
1991 Marks GS, Brien JF, Nakatsu K, McLaughlin BE. Does carbon monoxide have a physiological function? Trends in Pharmacological Sciences. 12: 185-8. PMID 1862533 DOI: 10.1016/0165-6147(91)90544-3  0.321
1989 Slack CJ, McLaughlin BE, Brien JF, Marks GS, Nakatsu K. Biotransformation of glyceryl trinitrate and isosorbide dinitrate in vascular smooth muscle made tolerant to organic nitrates. Canadian Journal of Physiology and Pharmacology. 67: 1381-5. PMID 2516767 DOI: 10.1139/Y89-221  0.316
1989 Marks GS, McLaughlin BE, MacMillan HF, Nakatsu K, Brien JF. Differential biotransformation of glyceryl trinitrate by red blood cell-supernatant fraction and pulmonary vein homogenate. Canadian Journal of Physiology and Pharmacology. 67: 417-22. PMID 2504466 DOI: 10.1139/Y89-066  0.345
1988 Slack CJ, McLaughlin BE, Nakatsu K, Marks GS, Brien JF. Nitric oxide-induced vasodilation of organic nitrate-tolerant rabbit aorta. Canadian Journal of Physiology and Pharmacology. 66: 1344-6. PMID 3149205 DOI: 10.1139/Y88-220  0.34
1972 Nakatsu K, Drummond GI. Adenylate metabolism and adenosine formation in the heart. The American Journal of Physiology. 223: 1119-27. PMID 4654345 DOI: 10.1152/Ajplegacy.1972.223.5.1119  0.543
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