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Oscar P. Kuipers - Publications

Affiliations: 
University of Groningen, Groningen, Netherlands 
Area:
Molecular genetics of prokaryots
Website:
http://www.knaw.nl/nl/leden/leden/11671
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352 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Marcelli B, Karsens H, Nijland M, Oudshoorn R, Kuipers OP, Kok J. Employing lytic phage-mediated horizontal gene transfer in Lactococcus lactis. Plos One. 15: e0238988. PMID 32925946 DOI: 10.1371/Journal.Pone.0238988  0.332
2020 Deng J, Viel JH, Chen J, Kuipers OP. Synthesis and Characterization of Heterodimers and Fluorescent Nisin Species by Incorporation of Methionine Analogs and Subsequent Click Chemistry. Acs Synthetic Biology. PMID 32786360 DOI: 10.1021/Acssynbio.0C00308  0.318
2020 Hernandez-Valdes JA, Dalglish MM, Hermans J, Kuipers OP. Development of Biosensors for Detection of Sulfur-Containing Amino Acids. Frontiers in Microbiology. 11: 1654. PMID 32760389 DOI: 10.3389/Fmicb.2020.01654  0.345
2020 Zhao X, Li Z, Kuipers OP. Mimicry of a Non-ribosomally Produced Antimicrobial, Brevicidine, by Ribosomal Synthesis and Post-translational Modification. Cell Chemical Biology. PMID 32707039 DOI: 10.1016/J.Chembiol.2020.07.005  0.348
2020 Li Z, Chakraborty P, de Vries RH, Song C, Zhao X, Roelfes G, Scheffers DJ, Kuipers OP. Characterization of two relacidines belonging to a novel class of circular lipopeptides that act against Gram-negative bacterial pathogens. Environmental Microbiology. PMID 32608161 DOI: 10.1111/1462-2920.15145  0.342
2020 Xia Y, Weng Y, Xu C, Wang D, Pan X, Tian Z, Xia B, Li H, Chen R, Liu C, Jin Y, Bai F, Cheng Z, Kuipers OP, Wu W. Endoribonuclease YbeY Is Essential for RNA Processing and Virulence in Pseudomonas aeruginosa. Mbio. 11. PMID 32605982 DOI: 10.1128/Mbio.00659-20  0.375
2020 van Tilburg AY, van Heel AJ, Stülke J, de Kok NAW, Rueff AS, Kuipers OP. MiniBacillus PG10 as a convenient and effective production host for lantibiotics. Acs Synthetic Biology. PMID 32551553 DOI: 10.1021/Acssynbio.0C00194  0.358
2020 Hernandez-Valdes JA, Aan de Stegge M, Hermans J, Teunis J, van Tatenhove-Pel RJ, Teusink B, Bachmann H, Kuipers OP. Enhancement of amino acid production and secretion by using a droplet-based biosensing and selection system. Metabolic Engineering Communications. 11: e00133. PMID 32551230 DOI: 10.1016/J.Mec.2020.E00133  0.357
2020 Hernandez-Valdes JA, Huang C, Kok J, Kuipers OP. Another breaker of the wall: The biological function of the Usp45 protein of . Applied and Environmental Microbiology. PMID 32532874 DOI: 10.1128/Aem.00903-20  0.38
2020 Hernandez-Valdes JA, Solopova A, Kuipers OP. Development of Biosensors for Detection of Diacetyl. Frontiers in Microbiology. 11: 1032. PMID 32523575 DOI: 10.3389/Fmicb.2020.01032  0.333
2020 Zhao X, Cebrian R, Fu Y, Rink R, Bosma T, Moll GN, Kuipers OP. High-throughput screening for substrate specificity-adapted mutants of the nisin dehydratase NisB. Acs Synthetic Biology. PMID 32374981 DOI: 10.1021/Acssynbio.0C00130  0.345
2020 Boonstra M, Schaffer M, Sousa J, Morawska L, Holsappel S, Hildebrandt P, Sappa PK, Rath H, de Jong A, Lalk M, Mäder U, Völker U, Kuipers OP. Analyses of competent and non-competent subpopulations of Bacillus subtilis reveal yhfW, yhxC and ncRNAs as novel players in competence. Environmental Microbiology. PMID 32249531 DOI: 10.1111/1462-2920.15005  0.369
2020 Li Z, Song C, Yi Y, Kuipers OP. Characterization of plant growth-promoting rhizobacteria from perennial ryegrass and genome mining of novel antimicrobial gene clusters. Bmc Genomics. 21: 157. PMID 32050906 DOI: 10.1186/S12864-020-6563-7  0.321
2020 Huang C, Hernandez-Valdes JA, Kuipers OP, Kok J. Lysis of an Di-peptidase Mutant and Rescue by Mutation in the Pleiotropic Regulator CodY. Applied and Environmental Microbiology. PMID 32005740 DOI: 10.1128/Aem.02937-19  0.388
2019 Perez M, Calles-Enríquez M, Del Rio B, Redruello B, de Jong A, Kuipers OP, Kok J, Martin MC, Ladero V, Fernandez M, Alvarez MA. Construction and characterization of a double mutant of Enterococcus faecalis that does not produce biogenic amines. Scientific Reports. 9: 16881. PMID 31727936 DOI: 10.1038/S41598-019-53175-5  0.357
2019 Cebrián R, Macia-Valero A, Jati AP, Kuipers OP. Design and Expression of Specific Hybrid Lantibiotics Active Against Pathogenic spp. Frontiers in Microbiology. 10: 2154. PMID 31616392 DOI: 10.3389/Fmicb.2019.02154  0.37
2019 Motib AS, Al-Bayati FAY, Manzoor I, Shafeeq S, Kadam A, Kuipers OP, Hiller NL, Andrew PW, Yesilkaya H. TprA/PhrA Quorum Sensing System Has a Major Effect on Pneumococcal Survival in Respiratory Tract and Blood, and Its Activity Is Controlled by CcpA and GlnR. Frontiers in Cellular and Infection Microbiology. 9: 326. PMID 31572692 DOI: 10.3389/Fcimb.2019.00326  0.307
2019 de Vries RH, Viel JH, Oudshoorn R, Kuipers OP, Roelfes G. Selective Modification of Ribosomally Synthesized and Post-Translationally Modified Peptides (RiPPs) through Diels-Alder Cycloadditions on Dehydroalanine Residues. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 31361053 DOI: 10.1002/Chem.201902907  0.321
2019 Marcelli B, de Jong A, Karsens H, Janzen T, Kok J, Kuipers OP. A specific sugar moiety in the Lactococcus lactis cell wall pellicle is required for infection by CHPC971, a member of the rare 1706 phage species. Applied and Environmental Microbiology. PMID 31350317 DOI: 10.1128/Aem.01224-19  0.326
2019 Li Q, Montalban-Lopez M, Kuipers OP. Feasability of Introducing a Thioether Ring in Vasopressin by Co-expression in . Frontiers in Microbiology. 10: 1508. PMID 31333616 DOI: 10.3389/Fmicb.2019.01508  0.31
2019 van Tatenhove-Pel RJ, Zwering E, Solopova A, Kuipers OP, Bachmann H. Ampicillin-treated Lactococcus lactis MG1363 populations contain persisters as well as viable but non-culturable cells. Scientific Reports. 9: 9867. PMID 31285492 DOI: 10.1038/S41598-019-46344-Z  0.321
2019 Solopova A, van Tilburg AY, Foito A, Allwood JW, Stewart D, Kulakauskas S, Kuipers OP. Engineering Lactococcus lactis for the production of unusual anthocyanins using tea as substrate. Metabolic Engineering. 54: 160-169. PMID 30978503 DOI: 10.1016/J.Ymben.2019.04.002  0.303
2019 Schmitt S, Montalbán-López M, Peterhoff D, Deng J, Wagner R, Held M, Kuipers OP, Panke S. Analysis of modular bioengineered antimicrobial lanthipeptides at nanoliter scale. Nature Chemical Biology. PMID 30936500 DOI: 10.1038/S41589-019-0250-5  0.339
2019 Kaunietis A, Buivydas A, Čitavičius DJ, Kuipers OP. Heterologous biosynthesis and characterization of a glycocin from a thermophilic bacterium. Nature Communications. 10: 1115. PMID 30846700 DOI: 10.1038/S41467-019-09065-5  0.42
2019 van Tilburg AY, Cao H, van der Meulen SB, Solopova A, Kuipers OP. Metabolic engineering and synthetic biology employing Lactococcus lactis and Bacillus subtilis cell factories. Current Opinion in Biotechnology. 59: 1-7. PMID 30784872 DOI: 10.1016/J.Copbio.2019.01.007  0.315
2019 Morabbi Heravi K, Manzoor I, Watzlawick H, de Jong A, Kuipers OP, Altenbuchner J. Phosphosugar stress in : Intracellular accumulation of mannose 6-phosphate derepresed the - operon from repression by GlcR. Journal of Bacteriology. PMID 30782637 DOI: 10.1128/Jb.00732-18  0.317
2018 Bron PA, Marcelli B, Mulder J, van der Els S, Morawska LP, Kuipers OP, Kok J, Kleerebezem M. Renaissance of traditional DNA transfer strategies for improvement of industrial lactic acid bacteria. Current Opinion in Biotechnology. 56: 61-68. PMID 30317145 DOI: 10.1016/J.Copbio.2018.09.004  0.333
2018 Cao H, Kuipers OP. Influence of global gene regulatory networks on single cell heterogeneity of green fluorescent protein production in Bacillus subtilis. Microbial Cell Factories. 17: 134. PMID 30165856 DOI: 10.1186/S12934-018-0985-9  0.375
2018 Cao H, Villatoro-Hernandez J, Weme RDO, Frenzel E, Kuipers OP. Boosting heterologous protein production yield by adjusting global nitrogen and carbon metabolic regulatory networks in Bacillus subtilis. Metabolic Engineering. PMID 30096425 DOI: 10.1016/J.Ymben.2018.08.001  0.371
2018 Yi Y, Li Z, Song C, Kuipers OP. Exploring plant-microbe interactions of the rhizobacteria Bacillus subtilis and Bacillus mycoides by use of the CRISPR-Cas9 system. Environmental Microbiology. PMID 30051589 DOI: 10.1111/1462-2920.14305  0.312
2018 Yi Y, Li Z, Kuipers OP. Plant-Microbe Interaction: Transcriptional Response of Bacillus Mycoides to Potato Root Exudates. Journal of Visualized Experiments : Jove. PMID 30010657 DOI: 10.3791/57606  0.323
2018 Afzal M, Shafeeq S, Kuipers OP. NADH-Mediated Gene Expression in and Role of Rex as a Transcriptional Repressor of the Rex-Regulon. Frontiers in Microbiology. 9: 1300. PMID 29971050 DOI: 10.3389/Fmicb.2018.01300  0.383
2018 Nickling JH, Baumann T, Schmitt FJ, Bartholomae M, Kuipers OP, Friedrich T, Budisa N. Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids. Journal of Visualized Experiments : Jove. PMID 29781997 DOI: 10.3791/57551  0.401
2018 Mu D, Lu J, Qiao M, Kuipers OP, Zhu J, Li X, Yang P, Zhao Y, Luo S, Wu X, Jiang S, Zheng Z. Heterologous signal peptides-directing secretion of Streptomyces mobaraensis transglutaminase by Bacillus subtilis. Applied Microbiology and Biotechnology. PMID 29691630 DOI: 10.1007/S00253-018-9000-Y  0.368
2018 Zhi X, Abdullah IT, Gazioglu O, Manzoor I, Shafeeq S, Kuipers OP, Hiller NL, Andrew PW, Yesilkaya H. Rgg-Shp regulators are important for pneumococcal colonization and invasion through their effect on mannose utilization and capsule synthesis. Scientific Reports. 8: 6369. PMID 29686372 DOI: 10.1038/S41598-018-24910-1  0.353
2018 Bartholomae M, Baumann T, Nickling JH, Peterhoff D, Wagner R, Budisa N, Kuipers OP. Expanding the Genetic Code of and to Incorporate Non-canonical Amino Acids for Production of Modified Lantibiotics. Frontiers in Microbiology. 9: 657. PMID 29681891 DOI: 10.3389/Fmicb.2018.00657  0.347
2018 Fu Y, Mu D, Qiao W, Zhu D, Wang X, Liu F, Xu H, Saris P, Kuipers OP, Qiao M. Co-expression of Nisin Z and Leucocin C as a Basis for Effective Protection Against in Pasteurized Milk. Frontiers in Microbiology. 9: 547. PMID 29628920 DOI: 10.3389/Fmicb.2018.00547  0.322
2018 Li Q, Montalban-Lopez M, Kuipers OP. Increasing Antimicrobial Activity of Nisin-based Lantibiotics Against Gram-negative Pathogens. Applied and Environmental Microbiology. PMID 29625984 DOI: 10.1128/Aem.00052-18  0.348
2018 Carvalho SM, Kloosterman TG, Manzoor I, Caldas J, Vinga S, Martinussen J, Saraiva LM, Kuipers OP, Neves AR. Interplay Between Capsule Expression and Uracil Metabolism inD39. Frontiers in Microbiology. 9: 321. PMID 29599757 DOI: 10.3389/Fmicb.2018.00321  0.397
2018 Montalbán-López M, Deng J, van Heel AJ, Kuipers OP. Specificity and Application of the Lantibiotic Protease NisP. Frontiers in Microbiology. 9: 160. PMID 29479343 DOI: 10.3389/Fmicb.2018.00160  0.362
2018 Frenzel E, Legebeke J, van Stralen A, van Kranenburg R, Kuipers OP. In vivo selection of sfGFP variants with improved and reliable functionality in industrially important thermophilic bacteria. Biotechnology For Biofuels. 11: 8. PMID 29371884 DOI: 10.1186/S13068-017-1008-5  0.302
2018 Carvalho SM, Freitas CS, Kuipers OP, Saraiva LM. Staphylococcus aureus metabolic strategies to survive nitrosative stress Free Radical Biology and Medicine. 120: S149-S150. DOI: 10.1016/J.Freeradbiomed.2018.04.493  0.325
2017 van den Esker MH, Kovács ÁT, Kuipers OP. From Cell Death to Metabolism: Holin-Antiholin Homologues with New Functions. Mbio. 8. PMID 29208748 DOI: 10.1128/Mbio.01963-17  0.312
2017 Yi Y, Frenzel E, Spoelder J, Elzenga JTM, van Elsas JD, Kuipers OP. Optimized fluorescent proteins for the rhizosphere-associated bacterium Bacillus mycoides with endophytic and biocontrol agent potential. Environmental Microbiology Reports. PMID 29195004 DOI: 10.1111/1758-2229.12607  0.312
2017 Perez M, Ladero V, Del Rio B, Redruello B, de Jong A, Kuipers O, Kok J, Martin MC, Fernandez M, Alvarez MA. The Relationship among Tyrosine Decarboxylase and Agmatine Deiminase Pathways in Enterococcus faecalis. Frontiers in Microbiology. 8: 2107. PMID 29163401 DOI: 10.3389/Fmicb.2017.02107  0.359
2017 Solopova A, Kok J, Kuipers OP. Disruption of a transcriptional repressor by an IS-element integration leads to the activation of a novel silent cellobiose transporter in Lactococcus lactis MG1363. Applied and Environmental Microbiology. PMID 28970222 DOI: 10.1128/Aem.01279-17  0.384
2017 Kok J, van Gijtenbeek LA, de Jong A, van der Meulen SB, Solopova A, Kuipers OP. The Evolution of gene regulation research in Lactococcus lactis. Fems Microbiology Reviews. 41: S220-S243. PMID 28830093 DOI: 10.1093/Femsre/Fux028  0.353
2017 Yi Y, de Jong A, Frenzel E, Kuipers OP. Comparative Transcriptomics of Bacillus mycoides Strains in Response to Potato-Root Exudates Reveals Different Genetic Adaptation of Endophytic and Soil Isolates. Frontiers in Microbiology. 8: 1487. PMID 28824604 DOI: 10.3389/Fmicb.2017.01487  0.334
2017 Bartholomae M, Buivydas A, Viel JH, Montalban-Lopez M, Kuipers OP. Major gene-regulatory mechanisms operating in ribosomally synthesized and post-translationally modified peptide (RiPP) biosynthesis. Molecular Microbiology. PMID 28787536 DOI: 10.1111/Mmi.13764  0.377
2017 Mulder J, Wels M, Kuipers OP, Kleerebezem M, Bron PA. Unleashing natural competence in Lactococcus lactis by induction of the competence regulator ComX. Applied and Environmental Microbiology. PMID 28778888 DOI: 10.1128/Aem.01320-17  0.354
2017 Carvalho SM, de Jong A, Kloosterman TG, Kuipers OP, Saraiva LM. The Staphylococcus aureus α-Acetolactate Synthase ALS Confers Resistance to Nitrosative Stress. Frontiers in Microbiology. 8: 1273. PMID 28744267 DOI: 10.3389/Fmicb.2017.01273  0.304
2017 Díez L, Solopova A, Fernández-Pérez R, González M, Tenorio C, Kuipers OP, Ruiz-Larrea F. Transcriptome analysis shows activation of the arginine deiminase pathway in Lactococcus lactis as a response to ethanol stress. International Journal of Food Microbiology. 257: 41-48. PMID 28644989 DOI: 10.1016/J.Ijfoodmicro.2017.05.017  0.317
2017 Hajaj B, Yesilkaya H, Shafeeq S, Zhi X, Benisty R, Tchalah S, Kuipers OP, Porat N. CodY Regulates Thiol Peroxidase Expression as Part of the Pneumococcal Defense Mechanism against H2O2 Stress. Frontiers in Cellular and Infection Microbiology. 7: 210. PMID 28596944 DOI: 10.3389/Fcimb.2017.00210  0.348
2017 Tracanna V, de Jong A, Medema MH, Kuipers OP. Mining prokaryotes for antimicrobial compounds: from diversity to function. Fems Microbiology Reviews. PMID 28402441 DOI: 10.1093/Femsre/Fux014  0.349
2017 Cao H, van Heel AJ, Ahmed H, Mols M, Kuipers OP. Cell surface engineering of Bacillus subtilis improves production yields of heterologously expressed α-amylases. Microbial Cell Factories. 16: 56. PMID 28376879 DOI: 10.1186/S12934-017-0674-0  0.31
2017 Afzal M, Kuipers OP, Shafeeq S. Niacin-mediated Gene Expression and Role of NiaR as a Transcriptional Repressor of niaX, nadC, and pnuC in Streptococcus pneumoniae. Frontiers in Cellular and Infection Microbiology. 7: 70. PMID 28337428 DOI: 10.3389/Fcimb.2017.00070  0.388
2017 Al-Bayati FA, Kahya HF, Damianou A, Shafeeq S, Kuipers OP, Andrew PW, Yesilkaya H. Pneumococcal galactose catabolism is controlled by multiple regulators acting on pyruvate formate lyase. Scientific Reports. 7: 43587. PMID 28240278 DOI: 10.1038/Srep43587  0.375
2017 Baumann T, Nickling JH, Bartholomae M, Buivydas A, Kuipers OP, Budisa N. Prospects of In vivo Incorporation of Non-canonical Amino Acids for the Chemical Diversification of Antimicrobial Peptides. Frontiers in Microbiology. 8: 124. PMID 28210246 DOI: 10.3389/Fmicb.2017.00124  0.345
2017 Krawczyk AO, de Jong A, Omony J, Holsappel S, Wells-Bennik MH, Kuipers OP, Eijlander RT. Spore heat-activation requirements and germination responses correlate with sequences of germinant receptors and with the presence of a specific spoVA2mob operon in food-borne strains of Bacillus subtilis. Applied and Environmental Microbiology. PMID 28130296 DOI: 10.1128/Aem.03122-16  0.318
2016 Afzal M, Manzoor I, Kuipers OP, Shafeeq S. Cysteine-Mediated Gene Expression and Characterization of the CmbR Regulon in Streptococcus pneumoniae. Frontiers in Microbiology. 7: 1929. PMID 27990139 DOI: 10.3389/Fmicb.2016.01929  0.38
2016 Afzal M, Shafeeq S, Manzoor I, Henriques-Normark B, Kuipers OP. N-acetylglucosamine-Mediated Expression of nagA and nagB in Streptococcus pneumoniae. Frontiers in Cellular and Infection Microbiology. 6: 158. PMID 27900287 DOI: 10.3389/Fcimb.2016.00158  0.339
2016 Eijlander RT, Holsappel S, de Jong A, Ghosh A, Christie G, Kuipers OP. SpoVT: From Fine-Tuning Regulator in Bacillus subtilis to Essential Sporulation Protein in Bacillus cereus. Frontiers in Microbiology. 7: 1607. PMID 27790204 DOI: 10.3389/Fmicb.2016.01607  0.398
2016 Nagler K, Krawczyk AO, De Jong A, Madela K, Hoffmann T, Laue M, Kuipers OP, Bremer E, Moeller R. Identification of Differentially Expressed Genes during Bacillus subtilis Spore Outgrowth in High-Salinity Environments Using RNA Sequencing. Frontiers in Microbiology. 7: 1564. PMID 27766092 DOI: 10.3389/Fmicb.2016.01564  0.357
2016 Afzal M, Shafeeq S, Ahmed H, Kuipers OP. N-acetylgalatosamine-Mediated Regulation of the aga Operon by AgaR in Streptococcus pneumoniae. Frontiers in Cellular and Infection Microbiology. 6: 101. PMID 27672623 DOI: 10.3389/Fcimb.2016.00101  0.352
2016 Visweswaran GR, Kurek D, Szeliga M, Pastrana FR, Kuipers OP, Kok J, Buist G. Expression of prophage-encoded endolysins contributes to autolysis of Lactococcus lactis. Applied Microbiology and Biotechnology. PMID 27660179 DOI: 10.1007/S00253-016-7822-Z  0.315
2016 Montalbán-López M, van Heel AJ, Kuipers OP. Employing the promiscuity of lantibiotic biosynthetic machineries to produce novel antimicrobials. Fems Microbiology Reviews. PMID 27591436 DOI: 10.1093/Femsre/Fuw034  0.322
2016 van den Esker MH, Kovács ÁT, Kuipers OP. YsbA and LytST are essential for pyruvate utilization in Bacillus subtilis. Environmental Microbiology. PMID 27422364 DOI: 10.1111/1462-2920.13454  0.344
2016 Perez M, Ladero V, Del Rio B, Redruello B, de Jong A, Kuipers OP, Kok J, Martin MC, Fernandez M, Alvarez MA. Transcriptome profiling of TDC cluster deletion mutant of Enterococcus faecalis V583. Genomics Data. 9: 67-9. PMID 27408815 DOI: 10.1016/J.Gdata.2016.06.012  0.365
2016 van Heel AJ, Kloosterman TG, Montalban-Lopez M, Deng JJ, Plat A, Baudu B, Hendriks D, Moll GN, Kuipers OP. Discovery, production and modification of 5 novel lantibiotics using the promiscuous nisin modification machinery. Acs Synthetic Biology. PMID 27294279 DOI: 10.1021/Acssynbio.6B00033  0.405
2016 Warda AK, Siezen RJ, Boekhorst J, Wells-Bennik MH, de Jong A, Kuipers OP, Nierop Groot MN, Abee T. Linking Bacillus cereus Genotypes and Carbohydrate Utilization Capacity. Plos One. 11: e0156796. PMID 27272929 DOI: 10.1371/Journal.Pone.0156796  0.329
2016 Mhatre E, Troszok A, Gallegos-Monterrosa R, Lindstädt S, Hölscher T, Kuipers OP, Kovács ÁT. The impact of manganese on biofilm development of Bacillus subtilis. Microbiology (Reading, England). PMID 27267987 DOI: 10.1099/Mic.0.000320  0.357
2016 Krawczyk AO, Berendsen EM, de Jong A, Boekhorst J, Wells-Bennik MH, Kuipers OP, Eijlander RT. A transposon present in specific strains of Bacillus subtilis negatively affects nutrient- and dodecylamine-induced spore germination. Environmental Microbiology. PMID 27234229 DOI: 10.1111/1462-2920.13386  0.371
2016 Krawczyk AO, de Jong A, Holsappel S, Eijlander RT, van Heel A, Berendsen EM, Wells-Bennik MH, Kuipers OP. Genome Sequences of 12 Spore-Forming Bacillus Species, Comprising Bacillus coagulans, Bacillus licheniformis, Bacillus amyloliquefaciens, Bacillus sporothermodurans, and Bacillus vallismortis, Isolated from Foods. Genome Announcements. 4. PMID 27174261 DOI: 10.1128/Genomea.00103-16  0.301
2016 Berendsen EM, Wells-Bennik MH, Krawczyk AO, de Jong A, van Heel A, Holsappel S, Eijlander RT, Kuipers OP. Draft Genome Sequences of Seven Thermophilic Spore-Forming Bacteria Isolated from Foods That Produce Highly Heat-Resistant Spores, Comprising Geobacillus spp., Caldibacillus debilis, and Anoxybacillus flavithermus. Genome Announcements. 4. PMID 27151781 DOI: 10.1128/Genomea.00105-16  0.321
2016 Berendsen EM, Boekhorst J, Kuipers OP, Wells-Bennik MH. A mobile genetic element profoundly increases heat resistance of bacterial spores. The Isme Journal. PMID 27105070 DOI: 10.1038/Ismej.2016.59  0.306
2016 Solopova A, Formosa-Dague C, Courtin P, Furlan S, Veiga P, Péchoux C, Armalytė J, Sadauskas M, Kok J, Hols P, Dufrêne YF, Kuipers OP, Chapot-Chartier MP, Kulakauskas S. Regulation of cell wall plasticity by nucleotide metabolism in Lactococcus lactis. The Journal of Biological Chemistry. PMID 27022026 DOI: 10.1074/Jbc.M116.714303  0.368
2016 Montalbán-López M, Kuipers OP. Posttranslational Peptide-Modification Enzymes in Action: Key Roles for Leaders and Glutamate. Cell Chemical Biology. 23: 318-9. PMID 26991100 DOI: 10.1016/J.Chembiol.2016.03.001  0.306
2016 Berendsen EM, Wells-Bennik MH, Krawczyk AO, de Jong A, van Heel A, Eijlander RT, Kuipers OP. Draft Genome Sequences of 10 Bacillus subtilis Strains That Form Spores with High or Low Heat Resistance. Genome Announcements. 4. PMID 26988043 DOI: 10.1128/Genomea.00124-16  0.312
2016 Del Rio B, Redruello B, Martin MC, Fernandez M, de Jong A, Kuipers OP, Ladero V, Alvarez MA. Transcriptome profiling of Lactococcus lactis subsp. cremoris CECT 8666 in response to agmatine. Genomics Data. 7: 112-4. PMID 26981381 DOI: 10.1016/J.Gdata.2015.12.003  0.396
2016 Yi Y, de Jong A, Spoelder J, Elzenga JT, van Elsas JD, Kuipers OP. Draft Genome Sequence of Bacillus mycoides M2E15, a Strain Isolated from the Endosphere of Potato. Genome Announcements. 4. PMID 26950325 DOI: 10.1128/Genomea.00031-16  0.345
2016 Zhou L, van Heel AJ, Montalban-Lopez M, Kuipers OP. Potentiating the Activity of Nisin against Escherichia coli. Frontiers in Cell and Developmental Biology. 4: 7. PMID 26904542 DOI: 10.3389/Fcell.2016.00007  0.348
2016 Zhou L, Shao J, Li Q, van Heel AJ, de Vries MP, Broos J, Kuipers OP. Incorporation of tryptophan analogues into the lantibiotic nisin. Amino Acids. PMID 26872656 DOI: 10.1007/S00726-016-2186-3  0.356
2016 Alvarez-Sieiro P, Montalbán-López M, Mu D, Kuipers OP. Bacteriocins of lactic acid bacteria: extending the family. Applied Microbiology and Biotechnology. PMID 26860942 DOI: 10.1007/S00253-016-7343-9  0.348
2015 Manzoor I, Shafeeq S, Afzal M, Kuipers OP. The Regulation of the AdcR Regulon in Streptococcus pneumoniae Depends Both on Zn(2+)- and Ni(2+)-Availability. Frontiers in Cellular and Infection Microbiology. 5: 91. PMID 26697415 DOI: 10.3389/Fcimb.2015.00091  0.322
2015 Del Rio B, Linares DM, Redruello B, Martin MC, Fernandez M, de Jong A, Kuipers OP, Ladero V, Alvarez MA. Transcriptomic profile of aguR deletion mutant of Lactococcus lactis subsp. cremoris CECT 8666. Genomics Data. 6: 228-30. PMID 26697381 DOI: 10.1016/J.Gdata.2015.10.002  0.403
2015 Manzoor I, Shafeeq S, Kuipers OP. Transcriptome analysis of Streptococcus pneumoniae D39 in the presence of cobalt. Genomics Data. 6: 151-3. PMID 26697359 DOI: 10.1016/J.Gdata.2015.08.033  0.387
2015 Manzoor I, Shafeeq S, Kuipers OP. Ni2+-Dependent and PsaR-Mediated Regulation of the Virulence Genes pcpA, psaBCA, and prtA in Streptococcus pneumoniae. Plos One. 10: e0142839. PMID 26562538 DOI: 10.1371/Journal.Pone.0142839  0.337
2015 Afzal M, Shafeeq S, Manzoor I, Kuipers OP. GalR Acts as a Transcriptional Activator of galKT in the Presence of Galactose in Streptococcus pneumoniae. Journal of Molecular Microbiology and Biotechnology. 25: 363-371. PMID 26544195 DOI: 10.1159/000439429  0.357
2015 Overkamp W, Kuipers OP. Transcriptional Profile of Bacillus subtilis sigF-Mutant during Vegetative Growth. Plos One. 10: e0141553. PMID 26506528 DOI: 10.1371/Journal.Pone.0141553  0.378
2015 Paixão L, Caldas J, Kloosterman TG, Kuipers OP, Vinga S, Neves AR. Transcriptional and metabolic effects of glucose on Streptococcus pneumoniae sugar metabolism. Frontiers in Microbiology. 6: 1041. PMID 26500614 DOI: 10.3389/Fmicb.2015.01041  0.317
2015 Shafeeq S, Afzal M, Henriques-Normark B, Kuipers OP. Transcriptional profiling of UlaR-regulated genes in Streptococcus pneumoniae. Genomics Data. 4: 57-9. PMID 26484177 DOI: 10.1016/J.Gdata.2015.02.004  0.369
2015 Detert Oude Weme R, Seidel G, Kuipers OP. Probing the regulatory effects of specific mutations in three major binding domains of the pleiotropic regulator CcpA of Bacillus subtilis. Frontiers in Microbiology. 6: 1051. PMID 26483775 DOI: 10.3389/Fmicb.2015.01051  0.373
2015 Manzoor I, Shafeeq S, Kloosterman TG, Kuipers OP. Co(2+)-dependent gene expression in Streptococcus pneumoniae: opposite effect of Mn(2+) and Co(2+) on the expression of the virulence genes psaBCA, pcpA, and prtA. Frontiers in Microbiology. 6: 748. PMID 26257722 DOI: 10.3389/Fmicb.2015.00748  0.372
2015 Manzoor I, Shafeeq S, Afzal M, Kuipers OP. Fucose-Mediated Transcriptional Activation of the fcs Operon by FcsR in Streptococcus pneumoniae. Journal of Molecular Microbiology and Biotechnology. 25: 120-8. PMID 26159073 DOI: 10.1159/000377724  0.356
2015 Grau RR, de Oña P, Kunert M, Leñini C, Gallegos-Monterrosa R, Mhatre E, Vileta D, Donato V, Hölscher T, Boland W, Kuipers OP, Kovács ÁT. A Duo of Potassium-Responsive Histidine Kinases Govern the Multicellular Destiny of Bacillus subtilis. Mbio. 6: e00581. PMID 26152584 DOI: 10.1128/Mbio.00581-15  0.357
2015 Michels K, Heinke R, Schöne P, Kuipers OP, Arnold N, Wessjohann LA. A fluorescence-based bioassay for antibacterials and its application in screening natural product extracts. The Journal of Antibiotics. PMID 26152282 DOI: 10.1038/Ja.2015.71  0.307
2015 Back A, Borges F, Mangavel C, Paris C, Rondags E, Kapel R, Aymes A, Rogniaux H, Pavlović M, van Heel AJ, Kuipers OP, Revol-Junelles AM, Cailliez-Grimal C. Recombinant pediocin in Lactococcus lactis: increased production by propeptide fusion and improved potency by co-production with PedC. Microbial Biotechnology. PMID 26147827 DOI: 10.1111/1751-7915.12285  0.374
2015 Linares DM, Del Rio B, Redruello B, Ladero V, Martin MC, de Jong A, Kuipers OP, Fernandez M, Alvarez MA. AguR is a transmembrane transcription activator of the putrescine biosynthesis operon in Lactococcus lactis, and acts in response to agmatine concentration. Applied and Environmental Microbiology. PMID 26116671 DOI: 10.1128/Aem.00959-15  0.416
2015 Ercan O, Bisschops MM, Overkamp W, Jørgensen TR, Ram AF, Smid EJ, Pronk JT, Kuipers OP, Daran-Lapujade P, Kleerebezem M. Physiological and transcriptional responses of different industrial microbes at near-zero specific growth rates. Applied and Environmental Microbiology. PMID 26048933 DOI: 10.1128/Aem.00944-15  0.345
2015 Afzal M, Shafeeq S, Manzoor I, Kuipers OP. Maltose-Dependent Transcriptional Regulation of the mal Regulon by MalR in Streptococcus pneumoniae. Plos One. 10: e0127579. PMID 26030923 DOI: 10.1371/Journal.Pone.0127579  0.375
2015 Afzal M, Manzoor I, Kuipers OP. A Fast and Reliable Pipeline for Bacterial Transcriptome Analysis Case study: Serine-dependent Gene Regulation in Streptococcus pneumoniae. Journal of Visualized Experiments : Jove. PMID 25938895 DOI: 10.3791/52649  0.371
2015 Schneider J, Klein T, Mielich-Süss B, Koch G, Franke C, Kuipers OP, Kovács ÁT, Sauer M, Lopez D. Spatio-temporal remodeling of functional membrane microdomains organizes the signaling networks of a bacterium. Plos Genetics. 11: e1005140. PMID 25909364 DOI: 10.1371/Journal.Pgen.1005140  0.308
2015 Goel A, Eckhardt TH, Puri P, de Jong A, Branco Dos Santos F, Giera M, Fusetti F, de Vos WM, Kok J, Poolman B, Molenaar D, Kuipers OP, Teusink B. Protein costs do not explain evolution of metabolic strategies and regulation of ribosomal content: does protein investment explain an anaerobic bacterial Crabtree effect? Molecular Microbiology. 97: 77-92. PMID 25828364 DOI: 10.1111/Mmi.13012  0.334
2015 Krawczyk AO, Berendsen EM, Eijlander RT, de Jong A, Wells-Bennik MH, Kuipers OP. Draft Genome Sequences of Four Bacillus thermoamylovorans Strains Isolated from Milk and Acacia Gum, a Food Ingredient. Genome Announcements. 3. PMID 25814599 DOI: 10.1128/Genomea.00165-15  0.31
2015 Mu D, Montalbán-López M, Deng J, Kuipers OP. Lantibiotic Reductase LtnJ Substrate Selectivity Assessed with a Collection of Nisin Derivatives as Substrates. Applied and Environmental Microbiology. 81: 3679-87. PMID 25795677 DOI: 10.1128/Aem.00475-15  0.369
2015 Khusainov R, van Heel AJ, Lubelski J, Moll GN, Kuipers OP. Identification of essential amino acid residues in the nisin dehydratase NisB. Frontiers in Microbiology. 6: 102. PMID 25767464 DOI: 10.3389/Fmicb.2015.00102  0.365
2015 Zhao X, de Jong A, Zhou Z, Kuipers OP. Complete Genome Sequence of Bacillus amyloliquefaciens Strain BH072, Isolated from Honey. Genome Announcements. 3. PMID 25767235 DOI: 10.1128/Genomea.00098-15  0.352
2015 Afzal M, Shafeeq S, Ahmed H, Kuipers OP. Sialic acid-mediated gene expression in Streptococcus pneumoniae and role of NanR as a transcriptional activator of the nan gene cluster. Applied and Environmental Microbiology. 81: 3121-31. PMID 25724955 DOI: 10.1128/Aem.00499-15  0.378
2015 Afzal M, Shafeeq S, Kuipers OP. Ascorbic acid-dependent gene expression in Streptococcus pneumoniae and the activator function of the transcriptional regulator UlaR2. Frontiers in Microbiology. 6: 72. PMID 25717320 DOI: 10.3389/Fmicb.2015.00072  0.383
2015 Zhou L, van Heel AJ, Kuipers OP. The length of a lantibiotic hinge region has profound influence on antimicrobial activity and host specificity. Frontiers in Microbiology. 6: 11. PMID 25688235 DOI: 10.3389/Fmicb.2015.00011  0.377
2015 Kuipers OP. Back to nature: a revival of natural strain improvement methodologies. Microbial Biotechnology. 8: 17-8. PMID 25488414 DOI: 10.1111/1751-7915.12232  0.334
2015 Afzal M, Shafeeq S, Henriques-Normark B, Kuipers OP. UlaR activates expression of the ula operon in Streptococcus pneumoniae in the presence of ascorbic acid. Microbiology (Reading, England). 161: 41-9. PMID 25355938 DOI: 10.1099/Mic.0.083899-0  0.384
2015 Benoit I, van den Esker MH, Patyshakuliyeva A, Mattern DJ, Blei F, Zhou M, Dijksterhuis J, Brakhage AA, Kuipers OP, de Vries RP, Kovács ÁT. Bacillus subtilis attachment to Aspergillus niger hyphae results in mutually altered metabolism. Environmental Microbiology. 17: 2099-113. PMID 25040940 DOI: 10.1111/1462-2920.12564  0.329
2015 Sorg RA, Kuipers OP, Veening JW. Gene expression platform for synthetic biology in the human pathogen Streptococcus pneumoniae. Acs Synthetic Biology. 4: 228-39. PMID 24845455 DOI: 10.1021/Sb500229S  0.389
2014 Daszczuk A, Dessalegne Y, Drenth I, Hendriks E, Jo E, van Lente T, Oldebesten A, Parrish J, Poljakova W, Purwanto AA, van Raaphorst R, Boonstra M, van Heel A, Herber M, van der Meulen S, ... ... Kuipers OP, et al. Bacillus subtilis biosensor engineered to assess meat spoilage. Acs Synthetic Biology. 3: 999-1002. PMID 25524109 DOI: 10.1021/Sb5000252  0.386
2014 Yuzenkova Y, Gamba P, Herber M, Attaiech L, Shafeeq S, Kuipers OP, Klumpp S, Zenkin N, Veening JW. Control of transcription elongation by GreA determines rate of gene expression in Streptococcus pneumoniae. Nucleic Acids Research. 42: 10987-99. PMID 25190458 DOI: 10.1093/Nar/Gku790  0.361
2014 Bakker D, Buckley AM, de Jong A, van Winden VJ, Verhoeks JP, Kuipers OP, Douce GR, Kuijper EJ, Smits WK, Corver J. The HtrA-like protease CD3284 modulates virulence of Clostridium difficile. Infection and Immunity. 82: 4222-32. PMID 25047848 DOI: 10.1128/Iai.02336-14  0.353
2014 Afzal M, Shafeeq S, Kuipers OP. LacR is a repressor of lacABCD and LacT is an activator of lacTFEG, constituting the lac gene cluster in Streptococcus pneumoniae. Applied and Environmental Microbiology. 80: 5349-58. PMID 24951784 DOI: 10.1128/Aem.01370-14  0.379
2014 Smith CM, Sandrini S, Datta S, Freestone P, Shafeeq S, Radhakrishnan P, Williams G, Glenn SM, Kuipers OP, Hirst RA, Easton AJ, Andrew PW, O'Callaghan C. Respiratory syncytial virus increases the virulence of Streptococcus pneumoniae by binding to penicillin binding protein 1a. A new paradigm in respiratory infection. American Journal of Respiratory and Critical Care Medicine. 190: 196-207. PMID 24941423 DOI: 10.1164/Rccm.201311-2110Oc  0.324
2014 Mehne FM, Schröder-Tittmann K, Eijlander RT, Herzberg C, Hewitt L, Kaever V, Lewis RJ, Kuipers OP, Tittmann K, Stülke J. Control of the diadenylate cyclase CdaS in Bacillus subtilis: an autoinhibitory domain limits cyclic di-AMP production. The Journal of Biological Chemistry. 289: 21098-107. PMID 24939848 DOI: 10.1074/Jbc.M114.562066  0.33
2014 van Gestel J, Weissing FJ, Kuipers OP, Kovács AT. Density of founder cells affects spatial pattern formation and cooperation in Bacillus subtilis biofilms. The Isme Journal. 8: 2069-79. PMID 24694715 DOI: 10.1038/Ismej.2014.52  0.304
2014 Irigül-Sönmez Ö, Köro?lu TE, Öztürk B, Kovács ÁT, Kuipers OP, Yazgan-Karata? A. In Bacillus subtilis LutR is part of the global complex regulatory network governing the adaptation to the transition from exponential growth to stationary phase. Microbiology (Reading, England). 160: 243-60. PMID 24196425 DOI: 10.1099/Mic.0.064675-0  0.417
2014 Eijlander RT, de Jong A, Krawczyk AO, Holsappel S, Kuipers OP. SporeWeb: an interactive journey through the complete sporulation cycle of Bacillus subtilis. Nucleic Acids Research. 42: D685-91. PMID 24170806 DOI: 10.1093/Nar/Gkt1007  0.333
2014 Diethmaier C, Newman JA, Kovács AT, Kaever V, Herzberg C, Rodrigues C, Boonstra M, Kuipers OP, Lewis RJ, Stülke J. The YmdB phosphodiesterase is a global regulator of late adaptive responses in Bacillus subtilis. Journal of Bacteriology. 196: 265-75. PMID 24163345 DOI: 10.1128/Jb.00826-13  0.402
2014 Puentes-Téllez PE, Kovács ÁT, Kuipers OP, van Elsas JD. Comparative genomics and transcriptomics analysis of experimentally evolved Escherichia coli MC1000 in complex environments. Environmental Microbiology. 16: 856-70. PMID 24033913 DOI: 10.1111/1462-2920.12239  0.341
2014 Siebring J, Elema MJ, Drubi Vega F, Kovács AT, Haccou P, Kuipers OP. Repeated triggering of sporulation in Bacillus subtilis selects against a protein that affects the timing of cell division. The Isme Journal. 8: 77-87. PMID 23924781 DOI: 10.1038/Ismej.2013.128  0.348
2013 Khusainov R, Kuipers OP. The presence of modifiable residues in the core peptide part of precursor nisin is not crucial for precursor nisin interactions with NisB- and NisC. Plos One. 8: e74890. PMID 24040355 DOI: 10.1371/Journal.Pone.0074890  0.321
2013 Overkamp W, Beilharz K, Detert Oude Weme R, Solopova A, Karsens H, Kovács Á, Kok J, Kuipers OP, Veening JW. Benchmarking various green fluorescent protein variants in Bacillus subtilis, Streptococcus pneumoniae, and Lactococcus lactis for live cell imaging. Applied and Environmental Microbiology. 79: 6481-90. PMID 23956387 DOI: 10.1128/Aem.02033-13  0.346
2013 Visweswaran GR, Steen A, Leenhouts K, Szeliga M, Ruban B, Hesseling-Meinders A, Dijkstra BW, Kuipers OP, Kok J, Buist G. AcmD, a homolog of the major autolysin AcmA of Lactococcus lactis, binds to the cell wall and contributes to cell separation and autolysis. Plos One. 8: e72167. PMID 23951292 DOI: 10.1371/Journal.Pone.0072167  0.357
2013 Abts A, Montalban-Lopez M, Kuipers OP, Smits SH, Schmitt L. NisC binds the FxLx motif of the nisin leader peptide. Biochemistry. 52: 5387-95. PMID 23869662 DOI: 10.1021/Bi4008116  0.328
2013 Eijlander RT, Kuipers OP. Live-cell imaging tool optimization to study gene expression levels and dynamics in single cells of Bacillus cereus. Applied and Environmental Microbiology. 79: 5643-51. PMID 23851094 DOI: 10.1128/Aem.01347-13  0.327
2013 Carvalho SM, Farshchi Andisi V, Gradstedt H, Neef J, Kuipers OP, Neves AR, Bijlsma JJ. Pyruvate oxidase influences the sugar utilization pattern and capsule production in Streptococcus pneumoniae. Plos One. 8: e68277. PMID 23844180 DOI: 10.1371/Journal.Pone.0068277  0.351
2013 Khusainov R, Moll GN, Kuipers OP. Identification of distinct nisin leader peptide regions that determine interactions with the modification enzymes NisB and NisC. Febs Open Bio. 3: 237-42. PMID 23772400 DOI: 10.1016/J.Fob.2013.05.001  0.306
2013 van Heel AJ, de Jong A, Montalbán-López M, Kok J, Kuipers OP. BAGEL3: Automated identification of genes encoding bacteriocins and (non-)bactericidal posttranslationally modified peptides. Nucleic Acids Research. 41: W448-53. PMID 23677608 DOI: 10.1093/Nar/Gkt391  0.347
2013 Mu D, Montalbán-López M, Masuda Y, Kuipers OP. Zirex: a novel zinc-regulated expression system for Lactococcus lactis. Applied and Environmental Microbiology. 79: 4503-8. PMID 23666339 DOI: 10.1128/Aem.00866-13  0.339
2013 van Heel AJ, Mu D, Montalbán-López M, Hendriks D, Kuipers OP. Designing and producing modified, new-to-nature peptides with antimicrobial activity by use of a combination of various lantibiotic modification enzymes. Acs Synthetic Biology. 2: 397-404. PMID 23654279 DOI: 10.1021/Sb3001084  0.338
2013 Carvalho SM, Kuipers OP, Neves AR. Environmental and nutritional factors that affect growth and metabolism of the pneumococcal serotype 2 strain D39 and its nonencapsulated derivative strain R6. Plos One. 8: e58492. PMID 23505518 DOI: 10.1371/Journal.Pone.0058492  0.306
2013 Shafeeq S, Kuipers OP, Kloosterman TG. Cellobiose-mediated gene expression in Streptococcus pneumoniae: a repressor function of the novel GntR-type regulator BguR. Plos One. 8: e57586. PMID 23469031 DOI: 10.1371/Journal.Pone.0057586  0.393
2013 de Jong A, Hansen ME, Kuipers OP, Kilstrup M, Kok J. The transcriptional and gene regulatory network of Lactococcus lactis MG1363 during growth in milk. Plos One. 8: e53085. PMID 23349698 DOI: 10.1371/Journal.Pone.0053085  0.336
2013 Kovács ÁT, Eckhardt TH, van Hartskamp M, van Kranenburg R, Kuipers OP. Functional analysis of the ComK protein of Bacillus coagulans. Plos One. 8: e53471. PMID 23301076 DOI: 10.1371/Journal.Pone.0053471  0.343
2013 Eckhardt TH, Skotnicka D, Kok J, Kuipers OP. Transcriptional regulation of fatty acid biosynthesis in Lactococcus lactis. Journal of Bacteriology. 195: 1081-9. PMID 23275247 DOI: 10.1128/Jb.02043-12  0.386
2012 Fibriansah G, Kovács ÁT, Pool TJ, Boonstra M, Kuipers OP, Thunnissen AM. Crystal structures of two transcriptional regulators from Bacillus cereus define the conserved structural features of a PadR subfamily. Plos One. 7: e48015. PMID 23189126 DOI: 10.1371/Journal.Pone.0048015  0.403
2012 Shafeeq S, Kloosterman TG, Rajendran V, Kuipers OP. Characterization of the ROK-family transcriptional regulator RokA of Streptococcus pneumoniae D39. Microbiology (Reading, England). 158: 2917-26. PMID 23082033 DOI: 10.1099/Mic.0.062919-0  0.378
2012 Khusainov R, Kuipers OP. When the leader gets loose: in vivo biosynthesis of a leaderless prenisin is stimulated by a trans-acting leader peptide. Chembiochem : a European Journal of Chemical Biology. 13: 2433-8. PMID 23070977 DOI: 10.1002/Cbic.201200437  0.323
2012 de Jong IG, Veening JW, Kuipers OP. Single cell analysis of gene expression patterns during carbon starvation in Bacillus subtilis reveals large phenotypic variation. Environmental Microbiology. 14: 3110-21. PMID 23033921 DOI: 10.1111/J.1462-2920.2012.02892.X  0.319
2012 Marciniak BC, Pabijaniak M, de Jong A, D?hring R, Seidel G, Hillen W, Kuipers OP. High- and low-affinity cre boxes for CcpA binding in Bacillus subtilis revealed by genome-wide analysis. Bmc Genomics. 13: 401. PMID 22900538 DOI: 10.1186/1471-2164-13-401  0.358
2012 Roces C, Pérez V, Campelo AB, Blanco D, Kok J, Kuipers OP, Rodríguez A, Martínez B. The putative lactococcal extracytoplasmic function anti-sigma factor llmg2447 determines resistance to the cell wall-active bacteriocin lcn972. Antimicrobial Agents and Chemotherapy. 56: 5520-7. PMID 22890757 DOI: 10.1128/Aac.01206-12  0.362
2012 de Jong A, Pietersma H, Cordes M, Kuipers OP, Kok J. PePPER: a webserver for prediction of prokaryote promoter elements and regulons. Bmc Genomics. 13: 299. PMID 22747501 DOI: 10.1186/1471-2164-13-299  0.319
2012 Montalbán-López M, Zhou L, Buivydas A, van Heel AJ, Kuipers OP. Increasing the success rate of lantibiotic drug discovery by Synthetic Biology. Expert Opinion On Drug Discovery. 7: 695-709. PMID 22680308 DOI: 10.1517/17460441.2012.693476  0.361
2012 Solopova A, Bachmann H, Teusink B, Kok J, Neves AR, Kuipers OP. A specific mutation in the promoter region of the silent cel cluster accounts for the appearance of lactose-utilizing Lactococcus lactis MG1363. Applied and Environmental Microbiology. 78: 5612-21. PMID 22660716 DOI: 10.1128/Aem.00455-12  0.313
2012 Marciniak BC, Trip H, van-der Veek PJ, Kuipers OP. Comparative transcriptional analysis of Bacillus subtilis cells overproducing either secreted proteins, lipoproteins or membrane proteins. Microbial Cell Factories. 11: 66. PMID 22624725 DOI: 10.1186/1475-2859-11-66  0.346
2012 Kovács AT, van Gestel J, Kuipers OP. The protective layer of biofilm: a repellent function for a new class of amphiphilic proteins. Molecular Microbiology. 85: 8-11. PMID 22607588 DOI: 10.1111/J.1365-2958.2012.08101.X  0.322
2012 Lindbäck T, Mols M, Basset C, Granum PE, Kuipers OP, Kovács ÁT. CodY, a pleiotropic regulator, influences multicellular behaviour and efficient production of virulence factors in Bacillus cereus. Environmental Microbiology. 14: 2233-46. PMID 22540344 DOI: 10.1111/J.1462-2920.2012.02766.X  0.407
2012 Marciniak BC, Trip H, Fusetti F, Kuipers OP. Regulation of ykrL (htpX) by Rok and YkrK, a novel type of regulator in Bacillus subtilis. Journal of Bacteriology. 194: 2837-45. PMID 22447908 DOI: 10.1128/Jb.00324-12  0.368
2012 Andisi VF, Hinojosa CA, de Jong A, Kuipers OP, Orihuela CJ, Bijlsma JJ. Pneumococcal gene complex involved in resistance to extracellular oxidative stress. Infection and Immunity. 80: 1037-49. PMID 22215735 DOI: 10.1128/Iai.05563-11  0.311
2012 Villatoro-Hernández J, Kuipers OP, Saucedo-Cárdenas O, Montes-de-Oca-Luna R. Heterologous protein expression by Lactococcus lactis. Methods in Molecular Biology (Clifton, N.J.). 824: 155-65. PMID 22160898 DOI: 10.1007/978-1-61779-433-9_8  0.319
2011 Blom EJ, Ridder AN, Lulko AT, Roerdink JB, Kuipers OP. Time-resolved transcriptomics and bioinformatic analyses reveal intrinsic stress responses during batch culture of Bacillus subtilis. Plos One. 6: e27160. PMID 22087258 DOI: 10.1371/Journal.Pone.0027160  0.337
2011 Kloosterman TG, Kuipers OP. Regulation of arginine acquisition and virulence gene expression in the human pathogen Streptococcus pneumoniae by transcription regulators ArgR1 and AhrC. The Journal of Biological Chemistry. 286: 44594-605. PMID 22084243 DOI: 10.1074/Jbc.M111.295832  0.408
2011 Carvalho SM, Kloosterman TG, Kuipers OP, Neves AR. CcpA ensures optimal metabolic fitness of Streptococcus pneumoniae. Plos One. 6: e26707. PMID 22039538 DOI: 10.1371/Journal.Pone.0026707  0.37
2011 Khusainov R, Heils R, Lubelski J, Moll GN, Kuipers OP. Determining sites of interaction between prenisin and its modification enzymes NisB and NisC. Molecular Microbiology. 82: 706-18. PMID 22011325 DOI: 10.1111/J.1365-2958.2011.07846.X  0.318
2011 Mellegård H, Kovács ÁT, Lindbäck T, Christensen BE, Kuipers OP, Granum PE. Transcriptional responses of Bacillus cereus towards challenges with the polysaccharide chitosan. Plos One. 6: e24304. PMID 21931677 DOI: 10.1371/Journal.Pone.0024304  0.388
2011 Marreddy RK, Pinto JP, Wolters JC, Geertsma ER, Fusetti F, Permentier HP, Kuipers OP, Kok J, Poolman B. The response of Lactococcus lactis to membrane protein production. Plos One. 6: e24060. PMID 21904605 DOI: 10.1371/Journal.Pone.0024060  0.308
2011 Campelo AB, Gaspar P, Roces C, Rodríguez A, Kok J, Kuipers OP, Neves AR, Martínez B. The Lcn972 bacteriocin-encoding plasmid pBL1 impairs cellobiose metabolism in Lactococcus lactis. Applied and Environmental Microbiology. 77: 7576-85. PMID 21890668 DOI: 10.1128/Aem.06107-11  0.378
2011 Pinto JP, Kuipers OP, Marreddy RK, Poolman B, Kok J. Efficient overproduction of membrane proteins in Lactococcus lactis requires the cell envelope stress sensor/regulator couple CesSR. Plos One. 6: e21873. PMID 21818275 DOI: 10.1371/Journal.Pone.0021873  0.336
2011 Shafeeq S, Kloosterman TG, Kuipers OP. CelR-mediated activation of the cellobiose-utilization gene cluster in Streptococcus pneumoniae. Microbiology (Reading, England). 157: 2854-61. PMID 21778207 DOI: 10.1099/Mic.0.051359-0  0.398
2011 Miro?czuk AM, Ma?u A, Kuipers OP, Kovács AT. Distinct roles of ComK1 and ComK2 in gene regulation in Bacillus cereus. Plos One. 6: e21859. PMID 21747963 DOI: 10.1371/Journal.Pone.0021859  0.37
2011 Shafeeq S, Yesilkaya H, Kloosterman TG, Narayanan G, Wandel M, Andrew PW, Kuipers OP, Morrissey JA. The cop operon is required for copper homeostasis and contributes to virulence in Streptococcus pneumoniae. Molecular Microbiology. 81: 1255-70. PMID 21736642 DOI: 10.1111/J.1365-2958.2011.07758.X  0.347
2011 Trip H, van der Veek PJ, Renniers TC, Meima R, Sagt CM, Mohrmann L, Kuipers OP. A novel screening system for secretion of heterologous proteins in Bacillus subtilis. Microbial Biotechnology. 4: 673-82. PMID 21624103 DOI: 10.1111/J.1751-7915.2011.00270.X  0.367
2011 Shafeeq S, Kloosterman TG, Kuipers OP. Transcriptional response of Streptococcus pneumoniae to Zn2+) limitation and the repressor/activator function of AdcR. Metallomics : Integrated Biometal Science. 3: 609-18. PMID 21603707 DOI: 10.1039/C1Mt00030F  0.365
2011 Bertram R, Rigali S, Wood N, Lulko AT, Kuipers OP, Titgemeyer F. Regulon of the N-acetylglucosamine utilization regulator NagR in Bacillus subtilis. Journal of Bacteriology. 193: 3525-36. PMID 21602348 DOI: 10.1128/Jb.00264-11  0.4
2011 Neef J, Andisi VF, Kim KS, Kuipers OP, Bijlsma JJ. Deletion of a cation transporter promotes lysis in Streptococcus pneumoniae. Infection and Immunity. 79: 2314-23. PMID 21422174 DOI: 10.1128/Iai.00677-10  0.319
2011 Kovács AT, Kuipers OP. Rok regulates yuaB expression during architecturally complex colony development of Bacillus subtilis 168. Journal of Bacteriology. 193: 998-1002. PMID 21097620 DOI: 10.1128/Jb.01170-10  0.364
2010 Westenberg MA, Roerdink JB, Kuipers OP, van Hijum SA. SpotXplore: a Cytoscape plugin for visual exploration of hotspot expression in gene regulatory networks. Bioinformatics (Oxford, England). 26: 2922-3. PMID 20861033 DOI: 10.1093/Bioinformatics/Btq535  0.315
2010 Neves AR, Pool WA, Solopova A, Kok J, Santos H, Kuipers OP. Towards enhanced galactose utilization by Lactococcus lactis. Applied and Environmental Microbiology. 76: 7048-60. PMID 20817811 DOI: 10.1128/Aem.01195-10  0.369
2010 Hyyryläinen HL, Marciniak BC, Dahncke K, Pietiäinen M, Courtin P, Vitikainen M, Seppala R, Otto A, Becher D, Chapot-Chartier MP, Kuipers OP, Kontinen VP. Penicillin-binding protein folding is dependent on the PrsA peptidyl-prolyl cis-trans isomerase in Bacillus subtilis Molecular Microbiology. 77: 108-127. PMID 20487272 DOI: 10.1111/J.1365-2958.2010.07188.X  0.347
2010 de Jong A, van Heel AJ, Kok J, Kuipers OP. BAGEL2: Mining for bacteriocins in genomic data Nucleic Acids Research. 38: W647-W651. PMID 20462861 DOI: 10.1093/Nar/Gkq365  0.318
2010 Kovács AT, Van Hartskamp M, Kuipers OP, Van Kranenburg R. Genetic tool development for a new host for biotechnology, the thermotolerant bacterium bacillus coagulans Applied and Environmental Microbiology. 76: 4085-4088. PMID 20400555 DOI: 10.1128/Aem.03060-09  0.34
2010 Veening JW, Kuipers OP. Gene position within a long transcript as a determinant for stochastic switching in bacteria Molecular Microbiology. 76: 269-272. PMID 20233302 DOI: 10.1111/J.1365-2958.2010.07113.X  0.389
2010 De Jong IG, Veening JW, Kuipers OP. Heterochronic phosphorelay gene expression as a source of heterogeneity in bacillus subtilis spore formation Journal of Bacteriology. 192: 2053-2067. PMID 20154131 DOI: 10.1128/Jb.01484-09  0.385
2010 Majchrzykiewicz JA, Lubelski J, Moll GN, Kuipers A, Bijlsma JJ, Kuipers OP, Rink R. Production of a class II two-component lantibiotic of Streptococcus pneumoniae using the class I nisin synthetic machinery and leader sequence. Antimicrobial Agents and Chemotherapy. 54: 1498-505. PMID 20100873 DOI: 10.1128/Aac.00883-09  0.364
2010 van Zutphen T, Baerends RJS, Susanna KA, de Jong A, Kuipers OP, Veenhuis M, van der Klei IJ. Adaptation of Hansenula polymorpha to methanol: A transcriptome analysis Bmc Genomics. 11. PMID 20044946 DOI: 10.1186/1471-2164-11-1  0.378
2010 Majchrzykiewicz JA, Kuipers OP, Bijlsma JJE. Generic and specific adaptive responses of Streptococcus pneumoniae to challenge with three distinct antimicrobial peptides, bacitracin, LL-37, and nisin Antimicrobial Agents and Chemotherapy. 54: 440-451. DOI: 10.1128/Aac.00769-09  0.359
2009 Grande Burgos MJ, Kovács AT, Mirończuk AM, Abriouel H, Gálvez A, Kuipers OP. Response of Bacillus cereus ATCC 14579 to challenges with sublethal concentrations of enterocin AS-48 Bmc Microbiology. 9. PMID 19863785 DOI: 10.1186/1471-2180-9-227  0.382
2009 Van Hijum SAFT, Medema MH, Kuipers OP. Mechanisms and evolution of control logic in prokaryotic transcriptional regulation Microbiology and Molecular Biology Reviews. 73: 481-509. PMID 19721087 DOI: 10.1128/Mmbr.00037-08  0.355
2009 Lubelski J, Khusainov R, Kuipers OP. Directionality and coordination of dehydration and ring formation during biosynthesis of the lantibiotic nisin Journal of Biological Chemistry. 284: 25962-25972. PMID 19620240 DOI: 10.1074/Jbc.M109.026690  0.319
2009 Kovács AT, Smits WK, Miro?czuk AM, Kuipers OP. Ubiquitous late competence genes in Bacillus species indicate the presence of functional DNA uptake machineries. Environmental Microbiology. 11: 1911-22. PMID 19453701 DOI: 10.1111/J.1462-2920.2009.01937.X  0.337
2009 Ridder ANJA, De Jong EJ, Jongbloed JDH, Kuipers OP. Subcellular localization of TatAd of Bacillus subtilis depends on the presence of TatCd or TatCy Journal of Bacteriology. 191: 4410-4418. PMID 19395490 DOI: 10.1128/Jb.00215-09  0.319
2009 Hendriksen WT, Bootsma HJ, van Diepen A, Estevão S, Kuipers OP, de Groot R, Hermans PWM. Strain-specific impact of PsaR of Streptococcus pneumoniae on global gene expression and virulence Microbiology. 155: 1569-1579. PMID 19372167 DOI: 10.1099/Mic.0.025072-0  0.334
2009 Blom EJ, Roerdink JB, Kuipers OP, van Hijum SA. MOTIFATOR: detection and characterization of regulatory motifs using prokaryote transcriptome data. Bioinformatics (Oxford, England). 25: 550-1. PMID 19168910 DOI: 10.1093/Bioinformatics/Btp013  0.323
2009 Chillappagari S, Miethke M, Trip H, Kuipers OP, Marahiel MA. Copper acquisition is mediated by YcnJ and regulated by YcnK and CsoR in bacillus subtilis Journal of Bacteriology. 191: 2362-2370. PMID 19168619 DOI: 10.1128/Jb.01616-08  0.33
2009 Barnett JP, Van Der Ploeg R, Eijlander RT, Nenninger A, Mendel S, Rozeboom R, Kuipers OP, Van Dijl JM, Robinson C. The twin-arginine translocation (Tat) systems from Bacillus subtilis display a conserved mode of complex organization and similar substrate recognition requirements Febs Journal. 276: 232-243. PMID 19049517 DOI: 10.1111/J.1742-4658.2008.06776.X  0.336
2009 Eijlander RT, Jongbloed JDH, Kuipers OP. Relaxed specificity of the Bacillus subtilis TatAdCd translocase in Tat-dependent protein secretion Journal of Bacteriology. 91: 196-202. PMID 18978042 DOI: 10.1128/Jb.01264-08  0.328
2009 Eijlander RT, Kolbusz MA, Berendsen EM, Kuipers OP. Effects of altered TatC proteins on protein secretion efficiency via the twin-arginine translocation pathway of Bacillus subtilis Microbiology. 155: 1776-1785. DOI: 10.1099/Mic.0.027987-0  0.354
2008 Mirończuk AM, Kovács AT, Kuipers OP. Induction of natural competence in Bacillus cereus ATCC14579 Microbial Biotechnology. 1: 226-235. PMID 21261842 DOI: 10.1111/J.1751-7915.2008.00023.X  0.327
2008 Nijland R, Kuipers OP. Optimization of protein secretion by Bacillus subtilis Recent Patents On Biotechnology. 2: 79-87. PMID 19075856 DOI: 10.2174/187220808784619694  0.34
2008 Blom EJ, Breitling R, Hofstede KJ, Roerdink JB, van Hijum SA, Kuipers OP. Prosecutor: parameter-free inference of gene function for prokaryotes using DNA microarray data, genomic context and multiple gene annotation sources. Bmc Genomics. 9: 495. PMID 18939968 DOI: 10.1186/1471-2164-9-495  0.343
2008 Zaidi AH, Bakkes PJ, Lubelski J, Agustiandari H, Kuipers OP, Driessen AJ. The ABC-type multidrug resistance transporter LmrCD is responsible for an extrusion-based mechanism of bile acid resistance in Lactococcus lactis. Journal of Bacteriology. 190: 7357-66. PMID 18790870 DOI: 10.1128/Jb.00485-08  0.316
2008 Kuipers OP, Poolman B, Hugenholtz J. 9th International Symposium on Lactic Acid Bacteria. Applied and Environmental Microbiology. 74: 4589. PMID 18586976 DOI: 10.1128/Aem.01384-08  0.327
2008 Lubelski J, Overkamp W, Kluskens LD, Moll GN, Kuipers OP. Influence of shifting positions of Ser, Thr, and Cys residues in prenisin on the efficiency of modification reactions and on the antimicrobial activities of the modified prepeptides. Applied and Environmental Microbiology. 74: 4680-5. PMID 18539792 DOI: 10.1128/Aem.00112-08  0.334
2008 Larsen R, Van Hijum SAFT, Martinussen J, Kuipers OP, Kok J. Transcriptome analysis of the Lactococcus lactis ArgR and AhrC regulons Applied and Environmental Microbiology. 74: 4768-4771. PMID 18539789 DOI: 10.1128/Aem.00117-08  0.349
2008 Kramer NE, Hasper HE, van den Bogaard PT, Morath S, de Kruijff B, Hartung T, Smid EJ, Breukink E, Kok J, Kuipers OP. Increased D-alanylation of lipoteichoic acid and a thickened septum are main determinants in the nisin resistance mechanism of Lactococcus lactis. Microbiology (Reading, England). 154: 1755-62. PMID 18524930 DOI: 10.1099/Mic.0.2007/015412-0  0.321
2008 Kloosterman TG, Witwicki RM, Van Der Kooi-Pol MM, Bijlsma JJE, Kuipers OP. Opposite effects of Mn2+ and Zn2+ on PsaR-mediated expression of the virulence genes pcpA, prtA, and psaBCA of Streptococcus pneumoniae Journal of Bacteriology. 190: 5382-5393. PMID 18515418 DOI: 10.1128/Jb.00307-08  0.357
2008 Buist G, Steen A, Kok J, Kuipers OP. LysM, a widely distributed protein motif for binding to (peptido)glycans Molecular Microbiology. 68: 838-847. PMID 18430080 DOI: 10.1111/J.1365-2958.2008.06211.X  0.347
2008 Van Der Voort M, Kuipers OP, Buist G, De Vos WM, Abee T. Assessment of CcpA-mediated catabolite control of gene expression in Bacillus cereus ATCC 14579 Bmc Microbiology. 8. PMID 18416820 DOI: 10.1186/1471-2180-8-62  0.401
2008 Veening JW, Igoshin OA, Eijlander RT, Nijland R, Hamoen LW, Kuipers OP. Transient heterogeneity in extracellular protease production by Bacillus subtilis. Molecular Systems Biology. 4: 184. PMID 18414485 DOI: 10.1038/Msb.2008.18  0.35
2008 van Hijum SAFT, Baerends RJS, Zomer AL, Karsens HA, Martin-Requena V, Trelles O, Kok J, Kuipers OP. Supervised Lowess normalization of comparative genome hybridization data - Application to lactococcal strain comparisons Bmc Bioinformatics. 9. PMID 18267014 DOI: 10.1186/1471-2105-9-93  0.32
2008 Hendriksen WT, Kloosterman TG, Bootsma HJ, Estevão S, De Groot R, Kuipers OP, Hermans PWM. Site-specific contributions of glutamine-dependent regulator GlnR and GlnR-regulated genes to virulence of Streptococcus pneumoniae Infection and Immunity. 76: 1230-1238. PMID 18174343 DOI: 10.1128/Iai.01004-07  0.374
2008 Widdick DA, Eijlander RT, van Dijl JM, Kuipers OP, Palmer T. A facile reporter system for the experimental identification of twin-arginine translocation (Tat) signal peptides from all kingdoms of life. Journal of Molecular Biology. 375: 595-603. PMID 18054046 DOI: 10.1016/J.Jmb.2007.11.002  0.31
2008 Mendel S, McCarthy A, Barnett JP, Eijlander RT, Nenninger A, Kuipers OP, Robinson C. The Escherichia coli TatABC System and a Bacillus subtilis TatAC-type System Recognise Three Distinct Targeting Determinants in Twin-arginine Signal Peptides Journal of Molecular Biology. 375: 661-672. PMID 18036542 DOI: 10.1016/J.Jmb.2007.09.087  0.353
2008 Barnett JP, Eijlander RT, Kuipers OP, Robinson C. A minimal Tat system from a gram-positive organism: a bifunctional TatA subunit participates in discrete TatAC and TatA complexes. The Journal of Biological Chemistry. 283: 2534-42. PMID 18029357 DOI: 10.1074/Jbc.M708134200  0.332
2008 Hendriksen WT, Bootsma HJ, Estevão S, Hoogenboezem T, De Jong A, De Groot R, Kuipers OP, Hermans PWM. CodY of Streptococcus pneumoniae: Link between nutritional gene regulation and colonization Journal of Bacteriology. 190: 590-601. PMID 18024519 DOI: 10.1128/Jb.00917-07  0.409
2008 Agustiandari H, Lubelski J, Van Den Berg Van Saparoea HB, Kuipers OP, Driessen AJM. LmrR is a transcriptional repressor of expression of the multidrug ABC transporter LmrCD in Lactococcus lactis Journal of Bacteriology. 190: 759-763. PMID 17993533 DOI: 10.1128/Jb.01151-07  0.326
2008 Lubelski J, Rink R, Khusainov R, Moll GN, Kuipers OP. Biosynthesis, immunity, regulation, mode of action and engineering of the model lantibiotic nisin. Cellular and Molecular Life Sciences : Cmls. 65: 455-76. PMID 17965835 DOI: 10.1007/S00018-007-7171-2  0.31
2007 Rink R, Wierenga J, Kuipers A, Kluskens LD, Driessen AJ, Kuipers OP, Moll GN. Dissection and modulation of the four distinct activities of nisin by mutagenesis of rings A and B and by C-terminal truncation. Applied and Environmental Microbiology. 73: 5809-16. PMID 17660303 DOI: 10.1128/Aem.01104-07  0.338
2007 Kloosterman TG, Van Der Kooi-Pol MM, Bijlsma JJE, Kuipers OP. The novel transcriptional regulator SczA mediates protection against Zn2+ stress by activation of the Zn2+-resistance gene czcD in Streptococcus pneumoniae Molecular Microbiology. 65: 1049-1063. PMID 17640279 DOI: 10.1111/J.1365-2958.2007.05849.X  0.362
2007 Burghout P, Bootsma HJ, Kloosterman TG, Bijlsma JJE, De Jongh CE, Kuipers OP, Hermans PWM. Search for genes essential for pneumococcal transformation: The RadA DNA repair protein plays a role in genomic recombination of donor DNA Journal of Bacteriology. 189: 6540-6550. PMID 17631629 DOI: 10.1128/Jb.00573-07  0.357
2007 Lulko AT, Veening JW, Buist G, Smits WK, Blom EJ, Beekman AC, Bron S, Kuipers OP. Production and secretion stress caused by overexpression of heterologous alpha-amylase leads to inhibition of sporulation and a prolonged motile phase in Bacillus subtilis. Applied and Environmental Microbiology. 73: 5354-62. PMID 17586671 DOI: 10.1128/Aem.00472-07  0.385
2007 Smits WK, Bongiorni C, Veening JW, Hamoen LW, Kuipers OP, Perego M. Temporal separation of distinct differentiation pathways by a dual specificity Rap-Phr system in Bacillus subtilis. Molecular Microbiology. 65: 103-20. PMID 17581123 DOI: 10.1111/J.1365-2958.2007.05776.X  0.334
2007 Varhimo E, Savijoki K, Jalava J, Kuipers OP, Varmanen P. Identification of a novel streptococcal gene cassette mediating SOS mutagenesis in Streptococcus uteris Journal of Bacteriology. 189: 5210-5222. PMID 17513475 DOI: 10.1128/Jb.00473-07  0.366
2007 Martínez B, Zomer AL, Rodríguez A, Kok J, Kuipers OP. Cell envelope stress induced by the bacteriocin Lcn972 is sensed by the lactococcal two-component system CesSR Molecular Microbiology. 64: 473-486. PMID 17493129 DOI: 10.1111/J.1365-2958.2007.05668.X  0.38
2007 Smits WK, Hoa TT, Hamoen LW, Kuipers OP, Dubnau D. Antirepression as a second mechanism of transcriptional activation by a minor groove binding protein. Molecular Microbiology. 64: 368-81. PMID 17493123 DOI: 10.1111/J.1365-2958.2007.05662.X  0.333
2007 Veiga P, Bulbarela-Sampieri C, Furlan S, Maisons A, Chapot-Chartier MP, Erkelenz M, Mervelet P, Noirot P, Frees D, Kuipers OP, Kok J, Gruss A, Buist G, Kulakauskas S. SpxB regulates O-acetylation-dependent resistance of Lactococcus lactis peptidoglycan to hydrolysis Journal of Biological Chemistry. 282: 19342-19354. PMID 17485463 DOI: 10.1074/Jbc.M611308200  0.349
2007 Susanna KA, Mironczuk AM, Smits WK, Hamoen LW, Kuipers OP. A single, specific thymine mutation in the ComK-binding site severely decreases binding and transcription activation by the competence transcription factor ComK of Bacillus subtilis. Journal of Bacteriology. 189: 4718-28. PMID 17468244 DOI: 10.1128/Jb.00281-07  0.307
2007 Romero D, De Vicente A, Rakotoaly RH, Dufour SE, Veening JW, Arrebola E, Cazorla FM, Kuipers OP, Paquot M, Pérez-García A. The iturin and fengycin families of lipopeptides are key factors in antagonism of Bacillus subtilis toward Podosphaera fusca Molecular Plant-Microbe Interactions. 20: 430-440. PMID 17427813 DOI: 10.1094/Mpmi-20-4-0430  0.343
2007 Duitman EH, Wyczawski D, Boven LG, Venema G, Kuipers OP, Hamoen LW. Novel methods for genetic transformation of natural Bacillus subtilis isolates used to study the regulation of the mycosubtilin and surfactin synthetases Applied and Environmental Microbiology. 73: 3490-3496. PMID 17416694 DOI: 10.1128/Aem.02751-06  0.364
2007 Wegmann U, O'Connell-Motherway M, Zomer A, Buist G, Shearman C, Canchaya C, Ventura M, Goesmann A, Gasson MJ, Kuipers OP, Van Sinderen D, Kok J. Complete genome sequence of the prototype lactic acid bacterium Lactococcus lactis subsp. cremoris MG1363 Journal of Bacteriology. 189: 3256-3270. PMID 17307855 DOI: 10.1128/Jb.01768-06  0.345
2007 Nijland R, Veening JW, Kuipers OP. A derepression system based on the Bacillus subtilis sporulation pathway offers dynamic control of heterologous gene expression Applied and Environmental Microbiology. 73: 2390-2393. PMID 17293533 DOI: 10.1128/Aem.02266-06  0.337
2007 Bijlsma JJE, Burghout P, Kloosterman TG, Bootsma HJ, De Jong A, Hermans PWM, Kuipers OP. Development of genomic array footprinting for identification of conditionally essential genes in Streptococcus pneumoniae Applied and Environmental Microbiology. 73: 1514-1524. PMID 17261526 DOI: 10.1128/Aem.01900-06  0.364
2007 Rink R, Wierenga J, Kuipers A, Kluskens LD, Driessen AJ, Kuipers OP, Moll GN. Production of dehydroamino acid-containing peptides by Lactococcus lactis. Applied and Environmental Microbiology. 73: 1792-6. PMID 17261515 DOI: 10.1128/Aem.02350-06  0.332
2007 Darmon E, Dorenbos R, Meens J, Freudl R, Antelmann H, Hecker M, Kuipers OP, Bron S, Quax WJ, Dubois JY, van Dijl JM. A disulfide bond-containing alkaline phosphatase triggers a BdbC-dependent secretion stress response in Bacillus subtilis. Applied and Environmental Microbiology. 72: 6876-85. PMID 17088376 DOI: 10.1128/Aem.01176-06  0.323
2007 Hendriksen WT, Silva N, Bootsma HJ, Blue CE, Paterson GK, Kerr AR, de Jong A, Kuipers OP, Hermans PW, Mitchell TJ. Regulation of gene expression in Streptococcus pneumoniae by response regulator 09 is strain dependent. Journal of Bacteriology. 189: 1382-9. PMID 17085554 DOI: 10.1128/Jb.01144-06  0.371
2007 Zomer AL, Buist G, Larsen R, Kok J, Kuipers OP. Time-resolved determination of the CcpA regulon of Lactococcus lactis subsp. cremons MG1363 Journal of Bacteriology. 189: 1366-1381. PMID 17028270 DOI: 10.1128/Jb.01013-06  0.385
2007 Buist G, Ridder AN, Kok J, Kuipers OP. Different subcellular locations of secretome components of Gram-positive bacteria. Microbiology (Reading, England). 152: 2867-74. PMID 17005968 DOI: 10.1099/Mic.0.29113-0  0.314
2007 Nijland R, Lindner C, van Hartskamp M, Hamoen LW, Kuipers OP. Heterologous production and secretion of Clostridium perfringens β-toxoid in closely related Gram-positive hosts Journal of Biotechnology. 127: 361-372. PMID 16959352 DOI: 10.1016/J.Jbiotec.2006.07.014  0.331
2007 Steen A, van Schalkwijk S, Buist G, Twigt M, Szeliga M, Meijer W, Kuipers OP, Kok J, Hugenholtz J. Lytr, a phage-derived amidase is most effective in induced lysis of Lactococcus lactis compared with other lactococcal amidases and glucosaminidases International Dairy Journal. 17: 926-936. DOI: 10.1016/J.Idairyj.2006.12.007  0.38
2007 Reviriego C, Fernández L, Kuipers OP, Kok J, Rodríguez JM. Enhanced production of pediocin PA-1 in wild nisin- and non-nisin-producing Lactococcus lactis strains of dairy origin International Dairy Journal. 17: 574-577. DOI: 10.1016/J.Idairyj.2006.05.013  0.312
2006 Lulko AT, Buist G, Kok J, Kuipers OP. Transcriptome analysis of temporal regulation of carbon metabolism by CcpA in Bacillus subtilis reveals additional target genes Journal of Molecular Microbiology and Biotechnology. 12: 82-95. PMID 17183215 DOI: 10.1159/000096463  0.417
2006 Kuipers A, Wierenga J, Rink R, Kluskens LD, Driessen AJ, Kuipers OP, Moll GN. Sec-mediated transport of posttranslationally dehydrated peptides in Lactococcus lactis. Applied and Environmental Microbiology. 72: 7626-33. PMID 17041158 DOI: 10.1128/Aem.01802-06  0.331
2006 Miethke M, Westers H, Blom EJ, Kuipers OP, Marahiel MA. Iron starvation triggers the stringent response and induces amino acid biosynthesis for bacillibactin production in Bacillus subtilis Journal of Bacteriology. 188: 8655-8657. PMID 17012385 DOI: 10.1128/Jb.01049-06  0.341
2006 Hasper HE, Kramer NE, Smith JL, Hillman JD, Zachariah C, Kuipers OP, de Kruijff B, Breukink E. An alternative bactericidal mechanism of action for lantibiotic peptides that target lipid II. Science (New York, N.Y.). 313: 1636-7. PMID 16973881 DOI: 10.1126/Science.1129818  0.302
2006 Veening JW, Smits WK, Hamoen LW, Kuipers OP. Single cell analysis of gene expression patterns of competence development and initiation of sporulation in Bacillus subtilis grown on chemically defined media. Journal of Applied Microbiology. 101: 531-41. PMID 16907804 DOI: 10.1111/J.1365-2672.2006.02911.X  0.322
2006 Lubelski J, de Jong A, van Merkerk R, Agustiandari H, Kuipers OP, Kok J, Driessen AJ. LmrCD is a major multidrug resistance transporter in Lactococcus lactis. Molecular Microbiology. 61: 771-81. PMID 16879641 DOI: 10.1111/J.1365-2958.2006.05267.X  0.335
2006 de Jong A, van Hijum SA, Bijlsma JJ, Kok J, Kuipers OP. BAGEL: a web-based bacteriocin genome mining tool. Nucleic Acids Research. 34: W273-9. PMID 16845009 DOI: 10.1093/Nar/Gkl237  0.379
2006 Pool WA, Neves AR, Kok J, Santos H, Kuipers OP. Natural sweetening of food products by engineering Lactococcus lactis for glucose production. Metabolic Engineering. 8: 456-64. PMID 16844396 DOI: 10.1016/J.Ymben.2006.05.003  0.314
2006 Larsen R, Kloosterman TG, Kok J, Kuipers OP. GlnR-mediated regulation of nitrogen metabolism in Lactococcus lactis. Journal of Bacteriology. 188: 4978-82. PMID 16788206 DOI: 10.1128/Jb.00025-06  0.327
2006 Kloosterman TG, Hendriksen WT, Bijlsma JJ, Bootsma HJ, van Hijum SA, Kok J, Hermans PW, Kuipers OP. Regulation of glutamine and glutamate metabolism by GlnR and GlnA in Streptococcus pneumoniae. The Journal of Biological Chemistry. 281: 25097-109. PMID 16787930 DOI: 10.1074/Jbc.M601661200  0.402
2006 Kramer NE, van Hijum SA, Knol J, Kok J, Kuipers OP. Transcriptome analysis reveals mechanisms by which Lactococcus lactis acquires nisin resistance. Antimicrobial Agents and Chemotherapy. 50: 1753-61. PMID 16641446 DOI: 10.1128/Aac.50.5.1753-1761.2006  0.364
2006 den Hengst CD, Groeneveld M, Kuipers OP, Kok J. Identification and functional characterization of the Lactococcus lactis CodY-regulated branched-chain amino acid permease BcaP (CtrA). Journal of Bacteriology. 188: 3280-9. PMID 16621821 DOI: 10.1128/Jb.188.9.3280-3289.2006  0.339
2006 Veening JW, Kuipers OP, Brul S, Hellingwerf KJ, Kort R. Effects of phosphorelay perturbations on architecture, sporulation, and spore resistance in biofilms of Bacillus subtilis. Journal of Bacteriology. 188: 3099-109. PMID 16585769 DOI: 10.1128/Jb.188.8.3099-3109.2006  0.359
2006 Smits WK, Kuipers OP, Veening JW. Phenotypic variation in bacteria: the role of feedback regulation. Nature Reviews. Microbiology. 4: 259-71. PMID 16541134 DOI: 10.1038/Nrmicro1381  0.318
2006 Susanna KA, Fusetti F, Thunnissen AM, Hamoen LW, Kuipers OP. Functional analysis of the competence transcription factor ComK of Bacillus subtilis by characterization of truncation variants. Microbiology (Reading, England). 152: 473-83. PMID 16436435 DOI: 10.1099/Mic.0.28357-0  0.361
2006 Kloosterman TG, Bijlsma JJ, Kok J, Kuipers OP. To have neighbour's fare: extending the molecular toolbox for Streptococcus pneumoniae. Microbiology (Reading, England). 152: 351-9. PMID 16436423 DOI: 10.1099/Mic.0.28521-0  0.382
2006 Bosma T, Kanninga R, Neef J, Audouy SAL, Van Roosmalen ML, Steen A, Buist G, Kok J, Kuipers OP, Robillard G, Leenhouts K. Novel surface display system for proteins on non-genetically modified gram-positive bacteria Applied and Environmental Microbiology. 72: 880-889. PMID 16391130 DOI: 10.1128/Aem.72.1.880-889.2006  0.32
2006 Susanna KA, den Hengst CD, Hamoen LW, Kuipers OP. Expression of transcription activator ComK of Bacillus subtilis in the heterologous host Lactococcus lactis leads to a genome-wide repression pattern: a case study of horizontal gene transfer. Applied and Environmental Microbiology. 72: 404-11. PMID 16391071 DOI: 10.1128/Aem.72.1.404-411.2006  0.396
2006 Bongers RS, Veening JW, Van Wieringen M, Kuipers OP, Kleerebezem M. Development and characterization of a subtilin-regulated expression system in Bacillus subtilis: strict control of gene expression by addition of subtilin. Applied and Environmental Microbiology. 71: 8818-24. PMID 16332878 DOI: 10.1128/Aem.71.12.8818-8824.2005  0.373
2005 Kluskens LD, Kuipers A, Rink R, de Boef E, Fekken S, Driessen AJ, Kuipers OP, Moll GN. Post-translational modification of therapeutic peptides by NisB, the dehydratase of the lantibiotic nisin. Biochemistry. 44: 12827-34. PMID 16171398 DOI: 10.1021/Bi050805P  0.328
2005 den Hengst CD, van Hijum SA, Geurts JM, Nauta A, Kok J, Kuipers OP. The Lactococcus lactis CodY regulon: identification of a conserved cis-regulatory element. The Journal of Biological Chemistry. 280: 34332-42. PMID 16040604 DOI: 10.1074/Jbc.M502349200  0.438
2005 Rink R, Kuipers A, de Boef E, Leenhouts KJ, Driessen AJ, Moll GN, Kuipers OP. Lantibiotic structures as guidelines for the design of peptides that can be modified by lantibiotic enzymes. Biochemistry. 44: 8873-82. PMID 15952794 DOI: 10.1021/Bi050081H  0.328
2005 Steen A, Buist G, Horsburgh GJ, Venema G, Kuipers OP, Foster SJ, Kok J. AcmA of Lactococcus lactis is an N-acetylglucosaminidase with an optimal number of LysM domains for proper functioning. The Febs Journal. 272: 2854-68. PMID 15943817 DOI: 10.1111/J.1742-4658.2005.04706.X  0.307
2005 Smits WK, Dubois JY, Bron S, van Dijl JM, Kuipers OP. Tricksy business: transcriptome analysis reveals the involvement of thioredoxin A in redox homeostasis, oxidative stress, sulfur metabolism, and cellular differentiation in Bacillus subtilis. Journal of Bacteriology. 187: 3921-30. PMID 15937154 DOI: 10.1128/Jb.187.12.3921-3930.2005  0.357
2005 Veening JW, Hamoen LW, Kuipers OP. Phosphatases modulate the bistable sporulation gene expression pattern in Bacillus subtilis. Molecular Microbiology. 56: 1481-94. PMID 15916600 DOI: 10.1111/J.1365-2958.2005.04659.X  0.362
2005 Barrière C, Veiga-da-Cunha M, Pons N, Guédon E, van Hijum SA, Kok J, Kuipers OP, Ehrlich DS, Renault P. Fructose utilization in Lactococcus lactis as a model for low-GC gram-positive bacteria: its regulator, signal, and DNA-binding site. Journal of Bacteriology. 187: 3752-61. PMID 15901699 DOI: 10.1128/Jb.187.11.3752-3761.2005  0.402
2005 Smits WK, Eschevins CC, Susanna KA, Bron S, Kuipers OP, Hamoen LW. Stripping Bacillus: ComK auto-stimulation is responsible for the bistable response in competence development. Molecular Microbiology. 56: 604-14. PMID 15819618 DOI: 10.1111/J.1365-2958.2005.04488.X  0.337
2005 Larsen R, Kok J, Kuipers OP. Interaction between ArgR and AhrC controls regulation of arginine metabolism in Lactococcus lactis. The Journal of Biological Chemistry. 280: 19319-30. PMID 15749710 DOI: 10.1074/Jbc.M413983200  0.373
2005 Albano M, Smits WK, Ho LT, Kraigher B, Mandic-Mulec I, Kuipers OP, Dubnau D. The Rok protein of Bacillus subtilis represses genes for cell surface and extracellular functions. Journal of Bacteriology. 187: 2010-9. PMID 15743949 DOI: 10.1128/Jb.187.6.2010-2019.2005  0.383
2005 den Hengst CD, Curley P, Larsen R, Buist G, Nauta A, van Sinderen D, Kuipers OP, Kok J. Probing direct interactions between CodY and the oppD promoter of Lactococcus lactis. Journal of Bacteriology. 187: 512-21. PMID 15629923 DOI: 10.1128/Jb.187.2.512-521.2005  0.385
2005 Steen A, Palumbo E, Deghorain M, Cocconcelli PS, Delcour J, Kuipers OP, Kok J, Buist G, Hols P. Autolysis of Lactococcus lactis is increased upon D-alanine depletion of peptidoglycan and lipoteichoic acids. Journal of Bacteriology. 187: 114-24. PMID 15601695 DOI: 10.1128/Jb.187.1.114-124.2005  0.329
2005 Kleerebezem M, Bongers R, Rutten G, de Vos WM, Kuipers OP. Autoregulation of subtilin biosynthesis in Bacillus subtilis: the role of the spa-box in subtilin-responsive promoters. Peptides. 25: 1415-24. PMID 15374645 DOI: 10.1016/J.Peptides.2003.11.025  0.388
2005 Kok J, Buist G, Zomer AL, van Hijum SA, Kuipers OP. Comparative and functional genomics of lactococci Fems Microbiology Reviews. 29: 411-433. DOI: 10.1016/J.Fmrre.2005.04.004  0.333
2004 Veening JW, Smits WK, Hamoen LW, Jongbloed JD, Kuipers OP. Visualization of differential gene expression by improved cyan fluorescent protein and yellow fluorescent protein production in Bacillus subtilis. Applied and Environmental Microbiology. 70: 6809-15. PMID 15528548 DOI: 10.1128/Aem.70.11.6809-6815.2004  0.358
2004 Campo N, Tjalsma H, Buist G, Stepniak D, Meijer M, Veenhuis M, Westermann M, Müller JP, Bron S, Kok J, Kuipers OP, Jongbloed JD. Subcellular sites for bacterial protein export. Molecular Microbiology. 53: 1583-99. PMID 15341641 DOI: 10.1111/J.1365-2958.2004.04278.X  0.311
2004 Tjalsma H, Antelmann H, Jongbloed JD, Braun PG, Darmon E, Dorenbos R, Dubois JY, Westers H, Zanen G, Quax WJ, Kuipers OP, Bron S, Hecker M, van Dijl JM. Proteomics of protein secretion by Bacillus subtilis: separating the "secrets" of the secretome. Microbiology and Molecular Biology Reviews : Mmbr. 68: 207-33. PMID 15187182 DOI: 10.1128/Mmbr.68.2.207-233.2004  0.336
2004 van den Bogaard PT, Hols P, Kuipers OP, Kleerebezem M, de Vos WM. Sugar utilisation and conservation of the gal-lac gene cluster in Streptococcus thermophilus. Systematic and Applied Microbiology. 27: 10-7. PMID 15053316 DOI: 10.1078/0723-2020-00258  0.353
2004 Kuipers A, de Boef E, Rink R, Fekken S, Kluskens LD, Driessen AJ, Leenhouts K, Kuipers OP, Moll GN. NisT, the transporter of the lantibiotic nisin, can transport fully modified, dehydrated, and unmodified prenisin and fusions of the leader peptide with non-lantibiotic peptides. The Journal of Biological Chemistry. 279: 22176-82. PMID 15044440 DOI: 10.1074/Jbc.M312789200  0.334
2004 Tjalsma H, Koetje EJ, Kiewiet R, Kuipers OP, Kolkman M, van der Laan J, Daskin R, Ferrari E, Bron S. Engineering of quorum-sensing systems for improved production of alkaline protease by Bacillus subtilis. Journal of Applied Microbiology. 96: 569-78. PMID 14962137 DOI: 10.1111/J.1365-2672.2004.02179.X  0.304
2004 Larsen R, Buist G, Kuipers OP, Kok J. ArgR and AhrC are both required for regulation of arginine metabolism in Lactococcus lactis. Journal of Bacteriology. 186: 1147-57. PMID 14762010 DOI: 10.1128/Jb.186.4.1147-1157.2004  0.392
2004 Susanna KA, van der Werff AF, den Hengst CD, Calles B, Salas M, Venema G, Hamoen LW, Kuipers OP. Mechanism of transcription activation at the comG promoter by the competence transcription factor ComK of Bacillus subtilis. Journal of Bacteriology. 186: 1120-8. PMID 14762007 DOI: 10.1128/Jb.186.4.1120-1128.2004  0.334
2004 Lindner C, Nijland R, van Hartskamp M, Bron S, Hamoen LW, Kuipers OP. Differential expression of two paralogous genes of Bacillus subtilis encoding single-stranded DNA binding protein. Journal of Bacteriology. 186: 1097-105. PMID 14762004 DOI: 10.1128/Jb.186.4.1097-1105.2004  0.398
2004 Kemperman R, Jonker M, Nauta A, Kuipers OP, Kok J. Functional analysis of the gene cluster involved in production of the bacteriocin circularin A by Clostridium beijerinckii ATCC 25752. Applied and Environmental Microbiology. 69: 5839-48. PMID 14532033 DOI: 10.1128/Aem.69.10.5839-5848.2003  0.409
2004 Antelmann H, Darmon E, Noone D, Veening JW, Westers H, Bron S, Kuipers OP, Devine KM, Hecker M, van Dijl JM. The extracellular proteome of Bacillus subtilis under secretion stress conditions. Molecular Microbiology. 49: 143-56. PMID 12823817 DOI: 10.1046/J.1365-2958.2003.03565.X  0.345
2004 Kuipers OP. Genomics and bioinformatics enhance research on food and gut bacteria Current Opinion in Biotechnology. 15: 83-85. DOI: 10.1016/J.Copbio.2004.03.003  0.366
2003 Westers H, Dorenbos R, van Dijl JM, Kabel J, Flanagan T, Devine KM, Jude F, Seror SJ, Beekman AC, Darmon E, Eschevins C, de Jong A, Bron S, Kuipers OP, Albertini AM, et al. Genome engineering reveals large dispensable regions in Bacillus subtilis. Molecular Biology and Evolution. 20: 2076-90. PMID 12949151 DOI: 10.1093/Molbev/Msg219  0.383
2003 Gajic O, Buist G, Kojic M, Topisirovic L, Kuipers OP, Kok J. Novel mechanism of bacteriocin secretion and immunity carried out by lactococcal multidrug resistance proteins. The Journal of Biological Chemistry. 278: 34291-8. PMID 12801935 DOI: 10.1074/Jbc.M211100200  0.395
2003 Steen A, Buist G, Leenhouts KJ, El Khattabi M, Grijpstra F, Zomer AL, Venema G, Kuipers OP, Kok J. Cell wall attachment of a widely distributed peptidoglycan binding domain is hindered by cell wall constituents. The Journal of Biological Chemistry. 278: 23874-81. PMID 12684515 DOI: 10.1074/Jbc.M211055200  0.303
2003 Kemperman R, Kuipers A, Karsens H, Nauta A, Kuipers O, Kok J. Identification and characterization of two novel clostridial bacteriocins, circularin A and closticin 574. Applied and Environmental Microbiology. 69: 1589-97. PMID 12620847 DOI: 10.1128/Aem.69.3.1589-1597.2003  0.362
2003 Hamoen LW, Venema G, Kuipers OP. Controlling competence in Bacillus subtilis: shared use of regulators. Microbiology (Reading, England). 149: 9-17. PMID 12576575 DOI: 10.1099/Mic.0.26003-0  0.33
2003 Kleerebezem M, Boekhorst J, van Kranenburg R, Molenaar D, Kuipers OP, Leer R, Tarchini R, Peters SA, Sandbrink HM, Fiers MW, Stiekema W, Lankhorst RM, Bron PA, Hoffer SM, Groot MN, et al. Complete genome sequence of Lactobacillus plantarum WCFS1. Proceedings of the National Academy of Sciences of the United States of America. 100: 1990-5. PMID 12566566 DOI: 10.1073/Pnas.0337704100  0.402
2002 Hamoen LW, Smits WK, de Jong A, Holsappel S, Kuipers OP. Improving the predictive value of the competence transcription factor (ComK) binding site in Bacillus subtilis using a genomic approach. Nucleic Acids Research. 30: 5517-28. PMID 12490720 DOI: 10.1093/Nar/Gkf698  0.351
2002 Klaenhammer T, Altermann E, Arigoni F, Bolotin A, Breidt F, Broadbent J, Cano R, Chaillou S, Deutscher J, Gasson M, van de Guchte M, Guzzo J, Hartke A, Hawkins T, Hols P, ... ... Kuipers O, et al. Discovering lactic acid bacteria by genomics. Antonie Van Leeuwenhoek. 82: 29-58. PMID 12369195 DOI: 10.1023/A:1020638309912  0.304
2002 Darmon E, Noone D, Masson A, Bron S, Kuipers OP, Devine KM, van Dijl JM. A novel class of heat and secretion stress-responsive genes is controlled by the autoregulated CssRS two-component system of Bacillus subtilis. Journal of Bacteriology. 184: 5661-71. PMID 12270824 DOI: 10.1128/Jb.184.20.5661-5671.2002  0.341
2002 Fernández M, Kleerebezem M, Kuipers OP, Siezen RJ, van Kranenburg R. Regulation of the metC-cysK operon, involved in sulfur metabolism in Lactococcus lactis. Journal of Bacteriology. 184: 82-90. PMID 11741847 DOI: 10.1128/Jb.184.1.82-90.2002  0.427
2002 Wouters JA, Frenkiel H, de Vos WM, Kuipers OP, Abee T. Cold shock proteins of Lactococcus lactis MG1363 are involved in cryoprotection and in the production of cold-induced proteins. Applied and Environmental Microbiology. 67: 5171-8. PMID 11679342 DOI: 10.1128/Aem.67.11.5171-5178.2001  0.36
2002 Kuipers OP, de Jong A, Baerends RJ, van Hijum SA, Zomer AL, Karsens HA, den Hengst CD, Kramer NE, Buist G, Kok J. Antonie Van Leeuwenhoek. 82: 113-122. DOI: 10.1023/A:1020691801251  0.306
2001 Miladinov N, Kuipers OP, Topisirovic L. Casitone-mediated expression of the prtP and prtM genes in Lactococcus lactis subsp. lactis BGIS29. Archives of Microbiology. 177: 54-61. PMID 11797045 DOI: 10.1007/S00203-001-0361-7  0.363
2001 Kleerebezem M, Kuipers OP, de Vos WM, Stiles ME, Quadri LE. A two-component signal-transduction cascade in Carnobacterium piscicola LV17B: two signaling peptides and one sensor-transmitter. Peptides. 22: 1597-601. PMID 11587787 DOI: 10.1016/S0196-9781(01)00494-6  0.304
2001 Monedero V, Kuipers OP, Jamet E, Deutscher J. Regulatory functions of serine-46-phosphorylated HPr in Lactococcus lactis. Journal of Bacteriology. 183: 3391-8. PMID 11344147 DOI: 10.1128/Jb.183.11.3391-3398.2001  0.301
2001 Kuipers OP. Complete DNA sequence of Lactococcus lactis adds flavor to genomics. Genome Research. 11: 673-4. PMID 11337466 DOI: 10.1101/Gr.188501  0.366
2001 Vaughan EE, van den Bogaard PT, Catzeddu P, Kuipers OP, de Vos WM. Activation of silent gal genes in the lac-gal regulon of Streptococcus thermophilus. Journal of Bacteriology. 183: 1184-94. PMID 11157930 DOI: 10.1128/Jb.183.4.1184-1194.2001  0.415
2001 Wiedemann I, Breukink E, van Kraaij C, Kuipers OP, Bierbaum G, de Kruijff B, Sahl HG. Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity. The Journal of Biological Chemistry. 276: 1772-9. PMID 11038353 DOI: 10.1074/Jbc.M006770200  0.33
2000 van den Bogaard PT, Kleerebezem M, Kuipers OP, de Vos WM. Control of lactose transport, beta-galactosidase activity, and glycolysis by CcpA in Streptococcus thermophilus: evidence for carbon catabolite repression by a non-phosphoenolpyruvate-dependent phosphotransferase system sugar. Journal of Bacteriology. 182: 5982-9. PMID 11029416 DOI: 10.1128/Jb.182.21.5982-5989.2000  0.352
2000 Wouters JA, Mailhes M, Rombouts FM, de Vos WM, Kuipers OP, Abee T. Physiological and regulatory effects of controlled overproduction of five cold shock proteins of Lactococcus lactis MG1363. Applied and Environmental Microbiology. 66: 3756-63. PMID 10966387 DOI: 10.1128/Aem.66.9.3756-3763.2000  0.318
2000 Wouters JA, Kamphuis HH, Hugenholtz J, Kuipers OP, de Vos WM, Abee T. Changes in glycolytic activity of Lactococcus lactis induced by low temperature. Applied and Environmental Microbiology. 66: 3686-91. PMID 10966377 DOI: 10.1128/Aem.66.9.3686-3691.2000  0.347
2000 Koebmann BJ, Nilsson D, Kuipers OP, Jensen PR. The membrane-bound H(+)-ATPase complex is essential for growth of Lactococcus lactis. Journal of Bacteriology. 182: 4738-43. PMID 10940012 DOI: 10.1128/Jb.182.17.4738-4743.2000  0.356
2000 Wouters JA, Rombouts FM, Kuipers OP, de Vos WM, Abee T. The role of cold-shock proteins in low-temperature adaptation of food-related bacteria. Systematic and Applied Microbiology. 23: 165-73. PMID 10930067 DOI: 10.1016/S0723-2020(00)80001-6  0.32
2000 Fernández L, Beerthuyzen MM, Brown J, Siezen RJ, Coolbear T, Holland R, Kuipers OP. Cloning, characterization, controlled overexpression, and inactivation of the major tributyrin esterase gene of Lactococcus lactis. Applied and Environmental Microbiology. 66: 1360-8. PMID 10742212 DOI: 10.1128/Aem.66.4.1360-1368.2000  0.411
2000 van Kraaij C, Breukink E, Rollema HS, Bongers RS, Kosters HA, de Kruijff B, Kuipers OP. Engineering a disulfide bond and free thiols in the lantibiotic nisin Z. European Journal of Biochemistry / Febs. 267: 901-9. PMID 10651829 DOI: 10.1046/J.1432-1327.2000.01075.X  0.342
2000 Fernández M, van Doesburg W, Rutten GA, Marugg JD, Alting AC, van Kranenburg R, Kuipers OP. Molecular and functional analyses of the metC gene of Lactococcus lactis, encoding cystathionine beta-lyase. Applied and Environmental Microbiology. 66: 42-8. PMID 10618201 DOI: 10.1128/Aem.66.1.42-48.2000  0.362
1999 Breukink E, Wiedemann I, van Kraaij C, Kuipers OP, Sahl HG, de Kruijff B. Use of the cell wall precursor lipid II by a pore-forming peptide antibiotic. Science (New York, N.Y.). 286: 2361-4. PMID 10600751 DOI: 10.1126/Science.286.5448.2361  0.308
1999 Wouters JA, Jeynov B, Rombouts FM, de Vos WM, Kuipers OP, Abee T. Analysis of the role of 7 kDa cold-shock proteins of Lactococcus lactis MG1363 in cryoprotection. Microbiology (Reading, England). 145: 3185-94. PMID 10589727 DOI: 10.1099/00221287-145-11-3185  0.307
1999 Wegmann U, Klein JR, Drumm I, Kuipers OP, Henrich B. Introduction of peptidase genes from Lactobacillus delbrueckii subsp. lactis into Lactococcus lactis and controlled expression. Applied and Environmental Microbiology. 65: 4729-33. PMID 10543778 DOI: 10.1128/Aem.65.11.4729-4733.1999  0.431
1999 Wouters JA, Rombouts FM, de Vos WM, Kuipers OP, Abee T. Cold shock proteins and low-temperature response of Streptococcus thermophilus CNRZ302. Applied and Environmental Microbiology. 65: 4436-42. PMID 10508072 DOI: 10.1128/Aem.65.10.4436-4442.1999  0.318
1999 Ra R, Beerthuyzen MM, de Vos WM, Saris PEJ, Kuipers OP. Effects of gene disruptions in the nisin gene cluster of Lactococcus lactis on nisin production and producer immunity. Microbiology (Reading, England). 1227-1233. PMID 10376839 DOI: 10.1099/13500872-145-5-1227  0.363
1999 Luesink EJ, van Herpen RE, Grossiord BP, Kuipers OP, de Vos WM. Transcriptional activation of the glycolytic las operon and catabolite repression of the gal operon in Lactococcus lactis are mediated by the catabolite control protein CcpA. Molecular Microbiology. 30: 789-98. PMID 10094627 DOI: 10.1046/J.1365-2958.1998.01111.X  0.42
1999 Luesink EJ, Marugg JD, Kuipers OP, de Vos WM. Characterization of the divergent sacBK and sacAR operons, involved in sucrose utilization by Lactococcus lactis. Journal of Bacteriology. 181: 1924-6. PMID 10074089 DOI: 10.1128/Jb.181.6.1924-1926.1999  0.352
1999 Wouters JA, Sanders JW, Kok J, de Vos WM, Kuipers OP, Abee T. Clustered organization and transcriptional analysis of a family of five csp genes of Lactococcus lactis MG1363. Microbiology (Reading, England). 2885-93. PMID 9802030 DOI: 10.1099/00221287-144-10-2885  0.368
1999 Luesink EJ, Beumer CMA, Kuipers OP, De Vos WM. Molecular Characterization of the Lactococcus lactis ptsHI Operon and Analysis of the Regulatory Role of HPr Journal of Bacteriology. 181: 764-771. DOI: 10.1128/Jb.181.3.764-771.1999  0.412
1999 Wegmann U, Klein JR, Drumm I, Kuipers OP, Henrich B. Introduction of Peptidase Genes from Lactobacillus delbrueckii subsp. lactis into Lactococcus lactis and Controlled Expression Applied and Environmental Microbiology. 65: 4729-4733. DOI: 10.1128/aem.65.11.4729-4733.1999  0.318
1998 Eichenbaum Z, Federle MJ, Marra D, de Vos WM, Kuipers OP, Kleerebezem M, Scott JR. Use of the lactococcal nisA promoter to regulate gene expression in gram-positive bacteria: comparison of induction level and promoter strength. Applied and Environmental Microbiology. 64: 2763-9. PMID 9687428 DOI: 10.1128/Aem.64.8.2763-2769.1998  0.383
1998 Vos WMd, Hols P, Kranenburg Rv, Luesink E, Kuipers OP, Oost Jvd, Kleerebezem M, Hugenholtz J. Making more of milk sugar by engineering lactic acid bacteria International Dairy Journal. 8: 227-233. DOI: 10.1016/S0958-6946(98)00049-1  0.306
1998 Kuipers OP, de Ruyter PG, Kleerebezem M, de Vos WM. Quorum sensing-controlled gene expression in lactic acid bacteria Journal of Biotechnology. 64: 15-21. DOI: 10.1016/S0168-1656(98)00100-X  0.415
1997 van den Hooven HW, Rollema HS, Siezen RJ, Hilbers CW, Kuipers OP. Structural features of the final intermediate in the biosynthesis of the lantibiotic nisin. Influence of the leader peptide. Biochemistry. 36: 14137-45. PMID 9369486 DOI: 10.1021/Bi9713106  0.311
1997 de Vos WM, Kleerebezem M, Kuipers OP. Expression systems for industrial Gram-positive bacteria with low guanine and cytosine content. Current Opinion in Biotechnology. 8: 547-53. PMID 9353236 DOI: 10.1016/S0958-1669(97)80027-4  0.36
1997 de Ruyter PG, Kuipers OP, Meijer WC, de Vos WM. Food-grade controlled lysis of Lactococcus lactis for accelerated cheese ripening. Nature Biotechnology. 15: 976-9. PMID 9335048 DOI: 10.1038/Nbt1097-976  0.352
1997 Quadri LE, Kleerebezem M, Kuipers OP, de Vos WM, Roy KL, Vederas JC, Stiles ME. Characterization of a locus from Carnobacterium piscicola LV17B involved in bacteriocin production and immunity: evidence for global inducer-mediated transcriptional regulation. Journal of Bacteriology. 179: 6163-71. PMID 9324267 DOI: 10.1128/Jb.179.19.6163-6171.1997  0.377
1997 Van Kraaij C, Breukink E, Rollema HS, Siezen RJ, Demel RA, De Kruijff B, Kuipers OP. Influence of charge differences in the C-terminal part of nisin on antimicrobial activity and signaling capacity European Journal of Biochemistry. 247: 114-120. PMID 9249016 DOI: 10.1111/J.1432-1033.1997.00114.X  0.332
1997 Kleerebezem M, Quadri LE, Kuipers OP, de Vos WM. Quorum sensing by peptide pheromones and two-component signal-transduction systems in Gram-positive bacteria. Molecular Microbiology. 24: 895-904. PMID 9219998 DOI: 10.1046/J.1365-2958.1997.4251782.X  0.359
1997 Kuipers OP, de Ruyter PG, Kleerebezem M, de Vos WM. Controlled overproduction of proteins by lactic acid bacteria. Trends in Biotechnology. 15: 135-40. PMID 9131833 DOI: 10.1016/S0167-7799(97)01029-9  0.345
1997 Rollema HS, Metzger JW, Both P, Kuipers OP, Siezen RJ. Structure and biological activity of chemically modified nisin A species. European Journal of Biochemistry. 241: 716-22. PMID 8944757 DOI: 10.1111/J.1432-1033.1996.00716.X  0.309
1997 Kuipers OP, Bierbaum G, Ottenwälder B, Dodd HM, Horn N, Metzger J, Kupke T, Gnau V, Bongers R, van den Bogaard P, Kosters H, Rollema HS, de Vos WM, Siezen RJ, Jung G, et al. Protein engineering of lantibiotics. Antonie Van Leeuwenhoek. 69: 161-69. PMID 8775976 DOI: 10.1007/Bf00399421  0.381
1997 Kleerebezem M, Beerthuyzen MM, Vaughan EE, de Vos WM, Kuipers OP. Controlled gene expression systems for lactic acid bacteria: transferable nisin-inducible expression cassettes for Lactococcus, Leuconostoc, and Lactobacillus spp. Applied and Environmental Microbiology. 63: 4581-4584. DOI: 10.1128/Aem.63.11.4581-4584.1997  0.381
1996 Siezen RJ, Kuipers OP, de Vos WM. Comparison of lantibiotic gene clusters and encoded proteins. Antonie Van Leeuwenhoek. 69: 171-84. PMID 8775977 DOI: 10.1007/Bf00399422  0.346
1996 de Ruyter PG, Kuipers OP, Beerthuyzen MM, van Alen-Boerrigter I, de Vos WM. Functional analysis of promoters in the nisin gene cluster of Lactococcus lactis. Journal of Bacteriology. 178: 3434-9. PMID 8655538 DOI: 10.1128/Jb.178.12.3434-3439.1996  0.382
1996 de Vos WM, Kuipers OP, van der Meer JR, Siezen RJ. Maturation pathway of nisin and other lantibiotics: post-translationally modified antimicrobial peptides exported by gram-positive bacteria. Molecular Microbiology. 17: 427-37. PMID 8559062 DOI: 10.1111/J.1365-2958.1995.Mmi_17030427.X  0.383
1996 de Ruyter PG, Kuipers OP, de Vos WM. Controlled gene expression systems for Lactococcus lactis with the food-grade inducer nisin. Applied and Environmental Microbiology. 62: 3662-3667. DOI: 10.1128/Aem.62.10.3662-3667.1996  0.376
1995 Siezen RJ, Rollema HS, Kuipers OP, de Vos WM. Homology modelling of the Lactococcus lactis leader peptidase NisP and its interaction with the precursor of the lantibiotic nisin. Protein Engineering. 8: 117-25. PMID 7630881 DOI: 10.1093/Protein/8.2.117  0.309
1995 van de Kamp M, van den Hooven HW, Konings RN, Bierbaum G, Sahl HG, Kuipers OP, Siezen RJ, de Vos WM, Hilbers CW, van de Ven FJ. Elucidation of the primary structure of the lantibiotic epilancin K7 from Staphylococcus epidermidis K7. Cloning and characterisation of the epilancin-K7-encoding gene and NMR analysis of mature epilancin K7. European Journal of Biochemistry / Febs. 230: 587-600. PMID 7607233 DOI: 10.1111/J.1432-1033.1995.Tb20600.X  0.302
1995 Kuipers OP, Beerthuyzen MM, de Ruyter PG, Luesink EJ, de Vos WM. Autoregulation of nisin biosynthesis in Lactococcus lactis by signal transduction. The Journal of Biological Chemistry. 270: 27299-304. PMID 7592991 DOI: 10.1074/Jbc.270.45.27299  0.4
1995 Kamp MVD, Hooven HWVD, Konings RNH, Bierbaum G, Sahl H, Kuipers OP, Siezen RJ, Vos WMD, Hilbers CW, Ven FJMVD. Elucidation of the Primary Structure of the Lantibiotic Epilancin K7 from Staphylococcus epidermidis K7 Febs Journal. 230: 587-600. DOI: 10.1111/J.1432-1033.1995.0587H.X  0.305
1995 Kuipers O, Rollema HS, Beerthuyzen MM, Siezen RJ, Vos WMd. Protein engineering and biosynthesis of nisin and regulation of transcription of the structural nisA gene International Dairy Journal. 5: 785-795. DOI: 10.1016/0958-6946(95)00032-1  0.413
1993 van der Meer JR, Polman J, Beerthuyzen MM, Siezen RJ, Kuipers OP, De Vos WM. Characterization of the Lactococcus lactis nisin A operon genes nisP, encoding a subtilisin-like serine protease involved in precursor processing, and nisR, encoding a regulatory protein involved in nisin biosynthesis. Journal of Bacteriology. 175: 2578-88. PMID 8478324 DOI: 10.1128/Jb.175.9.2578-2588.1993  0.388
1993 Kuipers OP, Rollema HS, de Vos WM, Siezen RJ. Biosynthesis and secretion of a precursor of nisin Z by Lactococcus lactis, directed by the leader peptide of the homologous lantibiotic subtilin from Bacillus subtilis. Febs Letters. 330: 23-7. PMID 8370453 DOI: 10.1016/0014-5793(93)80911-D  0.38
1993 Kuipers OP, Beerthuyzen MM, Siezen RJ, De Vos WM. Characterization of the nisin gene cluster nisABTCIPR of Lactococcus lactis. Requirement of expression of the nisA and nisI genes for development of immunity. European Journal of Biochemistry. 216: 281-91. PMID 7689965 DOI: 10.1111/J.1432-1033.1993.Tb18143.X  0.422
1993 de Vos WM, Mulders JW, Siezen RJ, Hugenholtz J, Kuipers OP. Properties of nisin Z and distribution of its gene, nisZ, in Lactococcus lactis. Applied and Environmental Microbiology. 59: 213-218. DOI: 10.1128/Aem.59.1.213-218.1993  0.353
1991 Kuipers OP, Vincent M, Brochon JC, Verheij HM, de Haas GH, Gallay J. Insight into the conformational dynamics of specific regions of porcine pancreatic phospholipase A2 from a time-resolved fluorescence study of a genetically inserted single tryptophan residue. Biochemistry. 30: 8771-85. PMID 1888737 DOI: 10.1021/Bi00100A008  0.554
1990 Kuipers OP, Kerver J, van Meersbergen J, Vis R, Dijkman R, Verheij HM, de Haas GH. Influence of size and polarity of residue 31 in porcine pancreatic phospholipase A2 on catalytic properties. Protein Engineering. 3: 599-603. PMID 2217133 DOI: 10.1093/Protein/3.7.599  0.558
1990 Thunnissen MM, Ab E, Kalk KH, Drenth J, Dijkstra BW, Kuipers OP, Dijkman R, de Haas GH, Verheij HM. X-ray structure of phospholipase A2 complexed with a substrate-derived inhibitor. Nature. 347: 689-91. PMID 2215698 DOI: 10.1038/347689A0  0.524
1990 Kuipers OP, Dekker N, Verheij HM, de Haas GH. Activities of native and tyrosine-69 mutant phospholipases A2 on phospholipid analogues. A reevaluation of the minimal substrate requirements. Biochemistry. 29: 6094-102. PMID 2116905 DOI: 10.1021/Bi00477A029  0.564
1990 Kuipers OP, van den Bergh CJ, Verheij HM, de Haas GH. Probing the mechanism of pancreatic phospholipase A2 with the aid of recombinant DNA techniques. Advances in Experimental Medicine and Biology. 279: 65-84. PMID 2096701 DOI: 10.1007/978-1-4613-0651-1_5  0.547
1990 Kuipers OP, Franken PA, Hendriks R, Verheij HM, de Haas GH. Function of the fully conserved residues Asp99, Tyr52 and Tyr73 in phospholipase A2. Protein Engineering. 4: 199-204. PMID 2075195 DOI: 10.1093/Protein/4.2.199  0.552
1989 Kuipers OP, Dijkman R, Pals CE, Verheij HM, de Haas GH. Evidence for the involvement of tyrosine-69 in the control of stereospecificity of porcine pancreatic phospholipase A2. Protein Engineering. 2: 467-71. PMID 2710783 DOI: 10.1093/Protein/2.6.467  0.552
1989 Kuipers OP, Thunnissen MM, de Geus P, Dijkstra BW, Drenth J, Verheij HM, de Haas GH. Enhanced activity and altered specificity of phospholipase A2 by deletion of a surface loop. Science (New York, N.Y.). 244: 82-5. PMID 2704992 DOI: 10.1126/Science.2704992  0.55
1987 de Geus P, van den Bergh CJ, Kuipers O, Verheij HM, Hoekstra WP, de Haas GH. Expression of porcine pancreatic phospholipase A2. Generation of active enzyme by sequence-specific cleavage of a hybrid protein from Escherichia coli. Nucleic Acids Research. 15: 3743-59. PMID 3295782 DOI: 10.1093/Nar/15.9.3743  0.577
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