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Eric A. Wold - Publications

Affiliations: 
University of Texas Medical Branch, Galveston, TX 
Area:
Medicinal Chemistry, 5-HT2C Receptor, CNS Drug Discovery
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21 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Chen J, Garcia EJ, Merritt CR, Zamora JC, Bolinger AA, Pazdrak K, Stafford SJ, Mifflin RC, Wold EA, Wild CT, Chen H, Anastasio NC, Cunningham KA, Zhou J. Discovery of Novel Oleamide Analogues as Brain-Penetrant Positive Allosteric Serotonin 5-HT Receptor and Dual 5-HT/5-HT Receptor Modulators. Journal of Medicinal Chemistry. PMID 37462530 DOI: 10.1021/acs.jmedchem.3c00908  0.43
2022 Liu Z, Li Y, Chen H, Lai HT, Wang P, Wu SY, Wold EA, Leonard PG, Joseph S, Hu H, Chiang CM, Brasier AR, Tian B, Zhou J. Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site. Journal of Medicinal Chemistry. PMID 34982556 DOI: 10.1021/acs.jmedchem.1c01851  0.45
2021 Liu Z, Wang P, Wold EA, Song Q, Zhao C, Wang C, Zhou J. Small-Molecule Inhibitors Targeting the Canonical WNT Signaling Pathway for the Treatment of Cancer. Journal of Medicinal Chemistry. PMID 33822624 DOI: 10.1021/acs.jmedchem.0c01799  0.469
2021 Xu J, Berastegui-Cabrera J, Carretero-Ledesma M, Chen H, Xue Y, Wold EA, Pachón J, Zhou J, Sánchez-Céspedes J. Discovery of a Small Molecule Inhibitor of Human Adenovirus Capable of Preventing Escape from the Endosome. International Journal of Molecular Sciences. 22. PMID 33562748 DOI: 10.3390/ijms22041617  0.397
2020 Ye N, Qin W, Tian S, Xu Q, Wold EA, Zhou J, Zhen XC. Small Molecules Selectively Targeting Sigma-1 Receptor for the Treatment of Neurological Diseases. Journal of Medicinal Chemistry. PMID 33111525 DOI: 10.1021/acs.jmedchem.0c01192  0.477
2020 Wold EA, Garcia EJ, Wild C, Miszkiel JM, Soto CA, Chen J, Pazdrak K, Fox RG, Anastasio NC, Cunningham KA, Zhou J. Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT2C Receptor Positive Allosteric Modulators with Enhanced Drug-Like Properties. Journal of Medicinal Chemistry. PMID 32567857 DOI: 10.1021/Acs.Jmedchem.9B01953  0.557
2020 Liu Z, Chen H, Wang P, Li Y, Wold EA, Leonard PG, Joseph S, Brasier AR, Tian B, Zhou J. Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffolding Hopping, Optimization and Pharmacological Evaluation. Journal of Medicinal Chemistry. PMID 32255647 DOI: 10.1021/Acs.Jmedchem.0C00035  0.538
2019 Wold EA, Wild CT, Cunningham KA, Zhou J. Targeting the 5-HT2C Receptor in Biological Context and the Current State of 5-HT2C Receptor Ligand Development. Current Topics in Medicinal Chemistry. PMID 31288724 DOI: 10.2174/1568026619666190709101449  0.514
2019 Liu G, Yin T, Kim H, Ding C, Yu Z, Wang H, Chen H, Yan R, Wold EA, Zou H, Liu X, Ding Y, Shen Q, Zhou J. Structure-activity relationship studies on Bax activator SMBA1 for the treatment of ER-positive and triple-negative breast cancer. European Journal of Medicinal Chemistry. 178: 589-605. PMID 31220676 DOI: 10.1016/J.Ejmech.2019.06.004  0.474
2019 Liu G, Wold EA, Zhou J. Applications of Bioorthogonal Chemistry in Tumor-Targeted Drug Discovery. Current Topics in Medicinal Chemistry. PMID 31074366 DOI: 10.2174/1568026619666190510091921  0.488
2018 Wold EA, Zhou J. GPCR Allosteric Modulators: Mechanistic Advantages and Therapeutic Applications. Current Topics in Medicinal Chemistry. 18: 2002-2006. PMID 30621563 DOI: 10.2174/1568026619999190101151837  0.486
2018 Ye N, Li B, Mao Q, Wold EA, Tian S, Allen JA, Zhou J. Orphan Receptor GPR88 as an Emerging Neurotherapeutic Target. Acs Chemical Neuroscience. PMID 30540906 DOI: 10.1021/Acschemneuro.8B00572  0.537
2018 Wold EA, Chen J, Cunningham KA, Zhou J. Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts. Journal of Medicinal Chemistry. PMID 30106578 DOI: 10.1021/Acs.Jmedchem.8B00875  0.571
2018 Wild CT, Miszkiel JM, Wold EA, Soto CA, Ding C, Hartley RM, White MA, Anastasio NC, Cunningham KA, Zhou J. Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-Carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT2C Receptor. Journal of Medicinal Chemistry. PMID 29620897 DOI: 10.1021/Acs.Jmedchem.8B00401  0.485
2018 Ding Y, Li D, Ding C, Wang P, Liu Z, Wold EA, Ye N, Chen H, White MA, Shen Q, Zhou J. Regio- and Stereospecific Synthesis of Oridonin D-ring Aziridinated Analogues for the Treatment of Triple-Negative Breast Cancer via Mediated Irreversible Covalent Warheads. Journal of Medicinal Chemistry. PMID 29528645 DOI: 10.1021/Acs.Jmedchem.7B01514  0.539
2018 Xu J, Wold EA, Ding Y, Shen Q, Zhou J. Therapeutic Potential of Oridonin and Its Analogs: From Anticancer and Antiinflammation to Neuroprotection. Molecules (Basel, Switzerland). 23. PMID 29470395 DOI: 10.3390/Molecules23020474  0.534
2018 Ding Y, Li D, Ding C, Liu Z, Wold EA, Ye N, Chen H, White MA, Shen Q, Zhou J. Abstract 2668: Regio- and stereospecific synthesis of oridonin D-ring aziridinated analogues for the treatment of triple-negative breast cancer via mediated irreversible covalent warheads Cancer Research. 78: 2668-2668. DOI: 10.1158/1538-7445.Am2018-2668  0.498
2017 Liu Z, Wang P, Chen H, Wold EA, Tian B, Brasier AR, Zhou J. Drug Discovery Targeting Bromodomain-Containing Protein 4 (BRD4). Journal of Medicinal Chemistry. PMID 28195723 DOI: 10.1021/Acs.Jmedchem.6B01761  0.533
2016 Ye N, Chen H, Wold EA, Shi PY, Zhou J. Therapeutic Potential of Spirooxindoles as Antiviral Agents. Acs Infectious Diseases. 2: 382-392. PMID 27627626 DOI: 10.1021/Acsinfecdis.6B00041  0.515
2016 Ding Y, Ding C, Ye N, Liu Z, Wold EA, Chen H, Wild C, Shen Q, Zhou J. Discovery and development of natural product oridonin-inspired anticancer agents. European Journal of Medicinal Chemistry. 122: 102-117. PMID 27344488 DOI: 10.1016/J.Ejmech.2016.06.015  0.566
2015 Liu Z, Wild C, Ding Y, Ye N, Chen H, Wold EA, Zhou J. BH4 domain of Bcl-2 as a novel target for cancer therapy. Drug Discovery Today. PMID 26631752 DOI: 10.1016/J.Drudis.2015.11.008  0.483
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