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Wukun Liu, Ph.D. - Publications

Affiliations: 
2008-2012 School of Pharmacy Free University of Berlin 
 2012-2017 School of Medicine Johns Hopkins University, Baltimore, MD 
 2017- Nanjing University of Chinese Medicine 
Area:
Medicinal Chemistry
Website:
https://smls.njucm.edu.cn/2021/0728/c5309a79311/page.htm
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Year Citation  Score
2024 Zhou L, Lu Y, Liu W, Wang S, Wang L, Zheng P, Zi G, Liu H, Liu W, Wei S. Drug conjugates for the treatment of lung cancer: from drug discovery to clinical practice. Experimental Hematology & Oncology. 13: 26. PMID 38429828 DOI: 10.1186/s40164-024-00493-8  0.303
2024 Ma X, Wang Z, Li Y, Wang Y, Liu W. Metal complexes bearing EGFR-inhibiting ligands as promising anticancer agents. Medicinal Research Reviews. PMID 38279970 DOI: 10.1002/med.22021  0.32
2023 Lu Y, Sheng X, Liu C, Liang Z, Wang X, Liu L, Wen Z, Yang Z, Du Q, Liu W. SERD-NHC-Au(I) complexes for dual targeting ER and TrxR to induce ICD in breast cancer. Pharmacological Research. 106731. PMID 36933755 DOI: 10.1016/j.phrs.2023.106731  0.326
2022 Chang X, Bian M, Liu L, Yang J, Yang Z, Wang Z, Lu Y, Liu W. Induction of immunogenic cell death by novel platinum-based anticancer agents. Pharmacological Research. 187: 106556. PMID 36403722 DOI: 10.1016/j.phrs.2022.106556  0.372
2022 Lu Y, Ma X, Chang X, Liang Z, Lv L, Shan M, Lu Q, Wen Z, Gust R, Liu W. Recent development of gold(I) and gold(III) complexes as therapeutic agents for cancer diseases. Chemical Society Reviews. PMID 35699475 DOI: 10.1039/d1cs00933h  0.607
2022 Yang Z, Huang S, Liu Y, Chang X, Liang Y, Li X, Xu Z, Wang S, Lu Y, Liu Y, Liu W. Biotin-Targeted Au(I) Radiosensitizer for Cancer Synergistic Therapy by Intervening with Redox Homeostasis and Inducing Ferroptosis. Journal of Medicinal Chemistry. PMID 35687871 DOI: 10.1021/acs.jmedchem.2c00300  0.453
2022 Xu Z, Xu J, Sun S, Lin W, Li Y, Lu Q, Li F, Yang Z, Lu Y, Liu W. Mecheliolide elicits ROS-mediated ERS driven immunogenic cell death in hepatocellular carcinoma. Redox Biology. 54: 102351. PMID 35671636 DOI: 10.1016/j.redox.2022.102351  0.338
2022 Xiao Q, Liu Y, Jiang G, Liu Y, Huang Y, Liu W, Zhang Z. Heteroleptic Gold(I)-bisNHC complex with excellent activity in vitro, ex vivo and in vivo against endometrial cancer. European Journal of Medicinal Chemistry. 236: 114302. PMID 35395440 DOI: 10.1016/j.ejmech.2022.114302  0.459
2022 Liu Y, Lu Y, Xu Z, Ma X, Chen X, Liu W. Repurposing of the gold drug auranofin and a review of its derivatives as antibacterial therapeutics. Drug Discovery Today. PMID 35192926 DOI: 10.1016/j.drudis.2022.02.010  0.411
2022 Luo M, Ma X, Jiang W, Zhang J, Liu W, Wei S, Liu H. Novel phosphanegold(I) thiolate complexes suppress de novo lipid synthesis in human lung cancer. European Journal of Medicinal Chemistry. 232: 114168. PMID 35176564 DOI: 10.1016/j.ejmech.2022.114168  0.389
2022 Bian M, Fan R, Yang Z, Chen Y, Xu Z, Lu Y, Liu W. Pt(II)-NHC Complex Induces ROS-ERS-Related DAMP Balance to Harness Immunogenic Cell Death in Hepatocellular Carcinoma. Journal of Medicinal Chemistry. PMID 35025488 DOI: 10.1021/acs.jmedchem.1c01248  0.311
2021 Guo L, Mohanty J, Liu W, Yonar T, Sun H, Minami T, Soleymani J, Moosa B, Zhou Q. Editorial: Frontiers in Chemistry-Rising Stars: Asia. Frontiers in Chemistry. 9: 811459. PMID 34900950 DOI: 10.3389/fchem.2021.811459  0.203
2021 Huang S, Sheng X, Bian M, Yang Z, Lu Y, Liu W. Synthesis and in vitro anticancer activities of selenium N-heterocyclic carbene compounds. Chemical Biology & Drug Design. PMID 34051050 DOI: 10.1111/cbdd.13900  0.423
2021 Massai L, Grguric-Sipka S, Liu W, Bertrand B, Pratesi A. Editorial: The Golden Future in Medicinal Chemistry: Perspectives and Resources From Old and New Gold-Based Drug Candidates. Frontiers in Chemistry. 9: 665244. PMID 33816443 DOI: 10.3389/fchem.2021.665244  0.375
2020 Sun Y, Lu Y, Bian M, Yang Z, Ma X, Liu W. Pt(II) and Au(III) complexes containing Schiff-base ligands: A promising source for antitumor treatment. European Journal of Medicinal Chemistry. 211: 113098. PMID 33348237 DOI: 10.1016/j.ejmech.2020.113098  0.364
2020 Lu Y, Liu W. Selective Estrogen Receptor Degraders (SERDs): A Promising Strategy for Estrogen Receptor Positive Endocrine-Resistant Breast Cancer. Journal of Medicinal Chemistry. PMID 33138369 DOI: 10.1021/acs.jmedchem.0c00913  0.298
2020 Xu Z, Yang L, Zhang X, Zhang Q, Yang Z, Liu Y, Wei S, Liu W. Discovery of Potential Flavonoid Inhibitors Against COVID-19 3CL Proteinase Based on Virtual Screening Strategy. Frontiers in Molecular Biosciences. 7: 556481. PMID 33134310 DOI: 10.3389/fmolb.2020.556481  0.483
2020 Bian M, Fan R, Jiang G, Wang Y, Lu Y, Liu W. Halo and Pseudohalo Gold(I)-NHC Complexes Derived from 4,5-Diarylimidazoles with Excellent in Vitro and in Vivo Anticancer Activity Against HCC. Journal of Medicinal Chemistry. PMID 32787098 DOI: 10.1021/Acs.Jmedchem.0C00257  0.467
2020 Li Y, Pasunooti KK, Peng H, Li RJ, Shi WQ, Liu W, Cheng Z, Head SA, Liu JO. Design and Synthesis of Tetrazole- and Pyridine-Containing Itraconazole Analogs as Potent Angiogenesis Inhibitors. Acs Medicinal Chemistry Letters. 11: 1111-1117. PMID 32550989 DOI: 10.1021/Acsmedchemlett.9B00438  0.746
2020 Bian M, Wang X, Sun Y, Liu W. Synthesis and biological evaluation of gold(III) Schiff base complexes for the treatment of hepatocellular carcinoma through attenuating TrxR activity. European Journal of Medicinal Chemistry. 193: 112234. PMID 32213395 DOI: 10.1016/J.Ejmech.2020.112234  0.434
2020 Liu W, Bian M, Sun Y, Liu Y, Xu Z, Fan R, Liu Z. A Gold(I) Complex Containing an Oleanolic Acid Derivative as a Potential Anti-ovarian Cancer Agent via Inhibiting TrxR and Activating ROS-mediated ERS. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 32037581 DOI: 10.1002/Chem.202000045  0.521
2020 Yang Z, Jiang G, Xu Z, Zhao S, Liu W. Advances in alkynyl gold complexes for use as potential anticancer agents Coordination Chemistry Reviews. 423: 213492. DOI: 10.1016/J.Ccr.2020.213492  0.467
2019 Liu JO, Guo Z, Cheng Z, Wang J, Liu W, Peng H, Wang Y, Rao S, Li R, Ying X, Korangath P, Liberti M, Li Y, Xie Y, Hong S, et al. Discovery of a potent GLUT inhibitor using rapafucin 3D microarrays. Angewandte Chemie (International Ed. in English). PMID 31591797 DOI: 10.1002/Anie.201905578  0.702
2019 Fan R, Bian M, Hu L, Liu W. A new rhodium(I) NHC complex inhibits TrxR: In vitro cytotoxicity and in vivo hepatocellular carcinoma suppression. European Journal of Medicinal Chemistry. 183: 111721. PMID 31577978 DOI: 10.1016/J.Ejmech.2019.111721  0.491
2019 Bian M, Fan R, Zhao S, Liu W. Targeting the thioredoxin system as a strategy for cancer therapy. Journal of Medicinal Chemistry. PMID 30963763 DOI: 10.1021/Acs.Jmedchem.8B01595  0.533
2018 Guo Z, Hong SY, Wang J, Rehan S, Liu W, Peng H, Das M, Li W, Bhat S, Peiffer B, Ullman BR, Tse CM, Tarmakova Z, Schiene-Fischer C, Fischer G, et al. Rapamycin-inspired macrocycles with new target specificity. Nature Chemistry. PMID 30532015 DOI: 10.1038/S41557-018-0187-4  0.659
2018 Li Y, Pasunooti KK, Li RJ, Liu W, Head SA, Shi WQ, Liu JO. Novel Tetrazole-containing Analogs of Itraconazole as Potent Anti-angiogenic Agents with Reduced CYP3A4 Inhibition. Journal of Medicinal Chemistry. PMID 30481027 DOI: 10.1021/Acs.Jmedchem.8B01252  0.759
2016 Liu W, Gust R. Update on metal N-heterocyclic carbene complexes as potential anti-tumor metallodrugs Coordination Chemistry Reviews. 329: 191-213. DOI: 10.1016/J.Ccr.2016.09.004  0.46
2015 Liu HR, Zhou C, Fan HQ, Tang JJ, Liu LB, Gao XH, Wang QA, Liu WK. Novel Potent and Selective Acetylcholinesterase Inhibitors as Potential Drugs for the Treatment of Alzheimer's Disease: Synthesis, Pharmacological Evaluation, and Molecular Modeling of Amino-Alkyl-Substituted Fluoro-Chalcones Derivatives. Chemical Biology & Drug Design. PMID 25588967 DOI: 10.1111/cbdd.12514  0.356
2014 Proetto MT, Liu W, Molchanov A, Sheldrick WS, Hagenbach A, Abram U, Gust R. Synthesis, characterization, and in vitro antiproliferative activity of [salophene]platinum(II) complexes. Chemmedchem. 9: 1176-87. PMID 24844419 DOI: 10.1002/Cmdc.201402123  0.655
2013 Liu W, Gust R. Metal N-heterocyclic carbene complexes as potential antitumor metallodrugs. Chemical Society Reviews. 42: 755-73. PMID 23147001 DOI: 10.1039/C2Cs35314H  0.632
2012 Liu W, Zhou J, Zhang T, Zhang H, Zhu H, Cheng Y, Gust R. Synthesis and biological evaluation of cyanoguanidine derivatives of loratadine. Bioorganic & Medicinal Chemistry Letters. 22: 6076-80. PMID 22959205 DOI: 10.1016/J.Bmcl.2012.08.041  0.684
2012 Liu W, Hua J, Zhou J, Zhang H, Zhu H, Cheng Y, Gust R. Synthesis and in vitro antitumor activity of novel scopoletin derivatives. Bioorganic & Medicinal Chemistry Letters. 22: 5008-12. PMID 22765897 DOI: 10.1016/J.Bmcl.2012.06.014  0.669
2012 Liu W, Zhou J, Zheng Y, Qi F, Zhang H, Qian H, Wang J, Cheng Y, Gust R. Design, synthesis and antiproliferative activity of 2-acetamidothiazole-5-carboxamide derivatives. Medicinal Chemistry (ShāRiqah (United Arab Emirates)). 8: 587-94. PMID 22548338 DOI: 10.2174/157340612801216418  0.704
2012 Proetto M, Liu W, Hagenbach A, Abram U, Gust R. Synthesis, characterization and in vitro antitumour activity of a series of novel platinum(II) complexes bearing Schiff base ligands. European Journal of Medicinal Chemistry. 53: 168-75. PMID 22534185 DOI: 10.1016/J.Ejmech.2012.03.053  0.625
2012 Liu W, Chen X, Gust R. Synthesis, antitumor, and antibacterial activity of bis[4,5-diarylimidazol-2-ylidene]methane derivatives. Archiv Der Pharmazie. 345: 557-64. PMID 22467535 DOI: 10.1002/Ardp.201100474  0.702
2012 Liu W, Zhou J, Zhang T, Zhu H, Qian H, Zhang H, Huang W, Gust R. Design and synthesis of thiourea derivatives containing a benzo[5,6]cyclohepta[1,2-b]pyridine moiety as potential antitumor and anti-inflammatory agents. Bioorganic & Medicinal Chemistry Letters. 22: 2701-4. PMID 22450132 DOI: 10.1016/J.Bmcl.2012.03.002  0.677
2012 Liu W, Bensdorf K, Proetto M, Hagenbach A, Abram U, Gust R. Synthesis, characterization, and in vitro studies of bis[1,3-diethyl-4,5-diarylimidazol-2-ylidene]gold(I/III) complexes. Journal of Medicinal Chemistry. 55: 3713-24. PMID 22424185 DOI: 10.1021/Jm3000196  0.649
2011 Liu W, Bensdorf K, Proetto M, Abram U, Hagenbach A, Gust R. NHC gold halide complexes derived from 4,5-diarylimidazoles: synthesis, structural analysis, and pharmacological investigations as potential antitumor agents. Journal of Medicinal Chemistry. 54: 8605-15. PMID 22091836 DOI: 10.1021/Jm201156X  0.705
2011 Liu W, Bensdorf K, Hagenbach A, Abram U, Niu B, Mariappan A, Gust R. Synthesis and biological studies of silver N-heterocyclic carbene complexes derived from 4,5-diarylimidazole. European Journal of Medicinal Chemistry. 46: 5927-34. PMID 22019187 DOI: 10.1016/J.Ejmech.2011.10.002  0.684
2011 Liu W, Zhou J, Liu Y, Liu H, Bensdorf K, Guo C, Gust R. Licofelone-nitric oxide donors as anticancer agents. Archiv Der Pharmazie. 344: 487-93. PMID 21681808 DOI: 10.1002/Ardp.201000397  0.676
2011 Liu W, Zhou J, Qi F, Bensdorf K, Li Z, Zhang H, Qian H, Huang W, Cai X, Cao P, Wellner A, Gust R. Synthesis and biological activities of 2-amino-thiazole-5-carboxylic acid phenylamide derivatives. Archiv Der Pharmazie. 344: 451-8. PMID 21598297 DOI: 10.1002/Ardp.201000281  0.69
2011 Liu W, Zhou J, Bensdorf K, Zhang H, Liu H, Wang Y, Qian H, Zhang Y, Wellner A, Rubner G, Huang W, Guo C, Gust R. Investigations on cytotoxicity and anti-inflammatory potency of licofelone derivatives. European Journal of Medicinal Chemistry. 46: 907-13. PMID 21295381 DOI: 10.1016/J.Ejmech.2011.01.002  0.685
2011 Liu W, Zhou J, Zhang H, Qian H, Yin J, Bensdorf K, Gust R. Synthesis and Biological Evaluation of Licofelone Derivatives as Anticancer and Anti-inflammatory Agents Letters in Drug Design & Discovery. 8: 911-917. DOI: 10.2174/157018011797655223  0.443
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