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Scott Rothbart - Publications

Affiliations: 
2010-2015 Head, Laboratory of Chromatin and Epigenetic Regulation The Van Andel Institute 
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63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Tiedemann RL, Hrit J, Du Q, Wiseman AK, Eden HE, Dickson BM, Kong X, Chomiak AA, Vaughan RM, Hebert JM, David Y, Zhou W, Baylin SB, Jones PA, Clark SJ, ... Rothbart SB, et al. UHRF1 ubiquitin ligase activity supports the maintenance of low-density CpG methylation. Biorxiv : the Preprint Server For Biology. PMID 38405904 DOI: 10.1101/2024.02.13.580169  0.433
2023 Tibben BM, Rothbart SB. Mechanisms of DNA Methylation Regulatory Function and Crosstalk with Histone Lysine Methylation. Journal of Molecular Biology. 168394. PMID 38092287 DOI: 10.1016/j.jmb.2023.168394  0.46
2023 Cordeiro-Spinetti E, Rothbart SB. Lysine methylation signaling in skeletal muscle biology: from myogenesis to clinical insights. The Biochemical Journal. 480: 1969-1986. PMID 38054592 DOI: 10.1042/BCJ20230223  0.423
2023 Ferrand J, Dabin J, Chevallier O, Kupai A, Rothbart SB, Polo SE. Mitotic chromatin marking governs asymmetric segregation of DNA damage. Biorxiv : the Preprint Server For Biology. PMID 37732208 DOI: 10.1101/2023.09.04.556166  0.348
2023 Compton SE, Kitchen-Goosen SM, DeCamp LM, Lau KH, Mabvakure B, Vos M, Williams KS, Wong KK, Shi X, Rothbart SB, Krawczyk CM, Jones RG. LKB1 controls inflammatory potential through CRTC2-dependent histone acetylation. Molecular Cell. PMID 37172591 DOI: 10.1016/j.molcel.2023.04.017  0.337
2023 Kupai A, Vaughan RM, Rothbart SB, Dickson BM. Analysis of histone antibody specificity directly in sequencing data using siQ-ChIP. Biorxiv : the Preprint Server For Biology. PMID 36945621 DOI: 10.1101/2023.03.08.531745  0.433
2023 Berryhill CA, Hanquier JN, Doud EH, Cordeiro-Spinetti E, Dickson BM, Rothbart SB, Mosley AL, Cornett EM. Global lysine methylome profiling using systematically characterized affinity reagents. Scientific Reports. 13: 377. PMID 36611042 DOI: 10.1038/s41598-022-27175-x  0.44
2022 Reske JJ, Wilson MR, Armistead B, Harkins S, Perez C, Hrit J, Adams M, Rothbart SB, Missmer SA, Fazleabas AT, Chandler RL. ARID1A-dependent maintenance of H3.3 is required for repressive CHD4-ZMYND8 chromatin interactions at super-enhancers. Bmc Biology. 20: 209. PMID 36153585 DOI: 10.1186/s12915-022-01407-y  0.541
2021 Morgan MAJ, Popova IK, Vaidya A, Burg JM, Marunde MR, Rendleman EJ, Dumar ZJ, Watson R, Meiners MJ, Howard SA, Khalatyan N, Vaughan RM, Rothbart SB, Keogh MC, Shilatifard A. A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer. Genes & Development. PMID 34819353 DOI: 10.1101/gad.348766.121  0.512
2021 Enríquez P, Krajewski K, Strahl BD, Rothbart SB, Dowen RH, Rose RB. Binding specificity and function of the SWI/SNF subunit SMARCA4 bromodomain interaction with acetylated histone H3K14. The Journal of Biological Chemistry. 101145. PMID 34473995 DOI: 10.1016/j.jbc.2021.101145  0.724
2021 Slaughter MJ, Shanle EK, Khan A, Chua KF, Hong T, Boxer LD, Allis CD, Josefowicz SZ, Garcia BA, Rothbart SB, Strahl BD, Davis IJ. HDAC inhibition results in widespread alteration of the histone acetylation landscape and BRD4 targeting to gene bodies. Cell Reports. 34: 108638. PMID 33472068 DOI: 10.1016/j.celrep.2020.108638  0.819
2020 Vaughan RM, Kupai A, Rothbart SB. Chromatin Regulation through Ubiquitin and Ubiquitin-like Histone Modifications. Trends in Biochemical Sciences. PMID 33308996 DOI: 10.1016/j.tibs.2020.11.005  0.546
2020 Franks JL, Martinez-Chacin RC, Wang X, Tiedemann RL, Bonacci T, Choudhury R, Bolhuis DL, Enrico TP, Mouery RD, Damrauer JS, Yan F, Harrison JS, Major MB, Hoadley KA, Suzuki A, ... Rothbart SB, et al. In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators. Plos Biology. 18: e3000975. PMID 33306668 DOI: 10.1371/journal.pbio.3000975  0.364
2020 Vaughan RM, Kupai A, Foley CA, Sagum CA, Tibben BM, Eden HE, Tiedemann RL, Berryhill CA, Patel V, Shaw KM, Krajewski K, Strahl BD, Bedford MT, Frye SV, Dickson BM, ... Rothbart SB, et al. The histone and non-histone methyllysine reader activities of the UHRF1 tandem Tudor domain are dispensable for the propagation of aberrant DNA methylation patterning in cancer cells. Epigenetics & Chromatin. 13: 44. PMID 33097091 DOI: 10.1186/s13072-020-00366-4  0.694
2020 Dickson BM, Tiedemann RL, Chomiak AA, Cornett EM, Vaughan RM, Rothbart SB. A physical basis for quantitative ChIP-sequencing. The Journal of Biological Chemistry. PMID 32994221 DOI: 10.1074/jbc.RA120.015353  0.302
2020 Armache A, Yang S, Martínez de Paz A, Robbins LE, Durmaz C, Cheong JQ, Ravishankar A, Daman AW, Ahimovic DJ, Klevorn T, Yue Y, Arslan T, Lin S, Panchenko T, Hrit J, ... ... Rothbart SB, et al. Histone H3.3 phosphorylation amplifies stimulation-induced transcription. Nature. PMID 32699416 DOI: 10.1038/S41586-020-2533-0  0.592
2020 Kupai A, Vaughan RM, Dickson BM, Rothbart SB. A Degenerate Peptide Library Approach to Reveal Sequence Determinants of Methyllysine-Driven Protein Interactions. Frontiers in Cell and Developmental Biology. 8: 241. PMID 32328492 DOI: 10.3389/Fcell.2020.00241  0.508
2020 Rothbart SB, Baylin SB. Epigenetic Therapy for Epithelioid Sarcoma. Cell. 181: 211. PMID 32302562 DOI: 10.1016/J.Cell.2020.03.042  0.307
2019 Colino-Sanguino Y, Cornett EM, Moulder D, Smith GC, Hrit J, Cordeiro-Spinetti E, Vaughan RM, Krajewski K, Rothbart SB, Clark SJ, Valdés-Mora F. A Read/Write Mechanism Connects p300 Bromodomain Function to H2A.Z Acetylation. Iscience. PMID 31727574 DOI: 10.1016/j.isci.2019.10.053  0.396
2019 Cornett EM, Ferry L, Defossez PA, Rothbart SB. Lysine Methylation Regulators Moonlighting outside the Epigenome. Molecular Cell. 75: 1092-1101. PMID 31539507 DOI: 10.1016/j.molcel.2019.08.026  0.515
2019 Vaughan RM, Rothbart SB, Dickson BM. The finger loop of the SRA domain in the E3 ligase UHRF1 is a regulator of ubiquitin targeting and is required for maintaining DNA methylation. The Journal of Biological Chemistry. PMID 31481468 DOI: 10.1074/Jbc.Ra119.010160  0.41
2019 Zhang Y, Jang Y, Lee JE, Ahn J, Xu L, Holden MR, Cornett EM, Krajewski K, Klein BJ, Wang SP, Dou Y, Roeder RG, Strahl BD, Rothbart SB, Shi X, et al. Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF. Nature Communications. 10: 2314. PMID 31127101 DOI: 10.1038/S41467-019-10324-8  0.703
2019 Kong X, Chen J, Xie W, Brown SM, Cai Y, Wu K, Fan D, Nie Y, Yegnasubramanian S, Tiedemann RL, Tao Y, Chiu Yen RW, Topper MJ, Zahnow CA, Easwaran H, ... Rothbart SB, et al. Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties. Cancer Cell. PMID 30956060 DOI: 10.1016/J.Ccell.2019.03.003  0.373
2018 Harris CJ, Scheibe M, Wongpalee SP, Liu W, Cornett EM, Vaughan RM, Li X, Chen W, Xue Y, Zhong Z, Yen L, Barshop WD, Rayatpisheh S, Gallego-Bartolome J, Groth M, ... ... Rothbart SB, et al. A DNA methylation reader complex that enhances gene transcription. Science (New York, N.Y.). 362: 1182-1186. PMID 30523112 DOI: 10.1126/Science.Aar7854  0.4
2018 Cornett EM, Dickson BM, Krajewski K, Spellmon N, Umstead A, Vaughan RM, Shaw KM, Versluis PP, Cowles MW, Brunzelle J, Yang Z, Vega IE, Sun ZW, Rothbart SB. A functional proteomics platform to reveal the sequence determinants of lysine methyltransferase substrate selectivity. Science Advances. 4: eaav2623. PMID 30498785 DOI: 10.1126/Sciadv.Aav2623  0.375
2018 Shah RN, Grzybowski AT, Cornett EM, Johnstone AL, Dickson BM, Boone BA, Cheek MA, Cowles MW, Maryanski D, Meiners MJ, Tiedemann RL, Vaughan RM, Arora N, Sun ZW, Rothbart SB, et al. Examining the Roles of H3K4 Methylation States with Systematically Characterized Antibodies. Molecular Cell. PMID 30244833 DOI: 10.1016/J.Molcel.2018.08.015  0.462
2018 Javasky E, Shamir I, Gandhi S, Egri S, Sandler O, Rothbart SB, Kaplan N, Jaffe JD, Goren A, Simon I. Study of mitotic chromatin supports a model of bookmarking by histone modifications and reveals nucleosome deposition patterns. Genome Research. PMID 30166406 DOI: 10.1101/Gr.230300.117  0.549
2018 Vaughan RM, Dickson BM, Whelihan MF, Johnstone AL, Cornett EM, Cheek MA, Ausherman CA, Cowles MW, Sun ZW, Rothbart SB. Chromatin structure and its chemical modifications regulate the ubiquitin ligase substrate selectivity of UHRF1. Proceedings of the National Academy of Sciences of the United States of America. PMID 30104358 DOI: 10.1073/Pnas.1806373115  0.51
2018 Vaughan RM, Dickson BM, Cornett EM, Harrison JS, Kuhlman B, Rothbart SB. Comparative biochemical analysis of UHRF proteins reveals molecular mechanisms that uncouple UHRF2 from DNA methylation maintenance. Nucleic Acids Research. PMID 29506131 DOI: 10.1093/Nar/Gky151  0.482
2018 Zhang ZM, Lu R, Wang P, Yu Y, Chen D, Gao L, Liu S, Ji D, Rothbart SB, Wang Y, Wang GG, Song J. Structural basis for DNMT3A-mediated de novo DNA methylation. Nature. PMID 29414941 DOI: 10.1038/Nature25477  0.35
2017 Veland N, Hardikar S, Zhong Y, Gayatri S, Dan J, Strahl BD, Rothbart SB, Bedford MT, Chen T. The Arginine Methyltransferase PRMT6 Regulates DNA Methylation and Contributes to Global DNA Hypomethylation in Cancer. Cell Reports. 21: 3390-3397. PMID 29262320 DOI: 10.1016/J.Celrep.2017.11.082  0.638
2017 Cornett EM, Dickson BM, Rothbart SB. Analysis of Histone Antibody Specificity with Peptide Microarrays. Journal of Visualized Experiments : Jove. PMID 28809825 DOI: 10.3791/55912  0.497
2017 Ma H, Duan J, Ke J, He Y, Gu X, Xu TH, Yu H, Wang Y, Brunzelle JS, Jiang Y, Rothbart SB, Xu HE, Li J, Melcher K. A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex. Science Advances. 3: e1601217. PMID 28630893 DOI: 10.1126/Sciadv.1601217  0.401
2017 Shanle EK, Shinsky SA, Bridgers JB, Bae N, Sagum C, Krajewski K, Rothbart SB, Bedford MT, Strahl BD. Histone peptide microarray screen of chromo and Tudor domains defines new histone lysine methylation interactions. Epigenetics & Chromatin. 10: 12. PMID 28293301 DOI: 10.1186/S13072-017-0117-5  0.811
2016 Strikoudis A, Lazaris C, Trimarchi T, Galvao Neto AL, Yang Y, Ntziachristos P, Rothbart S, Buckley S, Dolgalev I, Stadtfeld M, Strahl BD, Dynlacht BD, Tsirigos A, Aifantis I. Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a. Nature Cell Biology. PMID 27749823 DOI: 10.1038/Ncb3424  0.579
2016 Andrews FH, Tong Q, Sullivan KD, Cornett EM, Zhang Y, Ali M, Ahn J, Pandey A, Guo AH, Strahl BD, Costello JC, Espinosa JM, Rothbart SB, Kutateladze TG. Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase. Cell Reports. 16: 3195-207. PMID 27653685 DOI: 10.1016/J.Celrep.2016.08.050  0.647
2016 Harrison JS, Cornett EM, Goldfarb D, DaRosa PA, Li ZM, Yan F, Dickson BM, Guo AH, Cantu DV, Kaustov L, Brown PJ, Arrowsmith CH, Erie DA, Major MB, Klevit RE, ... ... Rothbart SB, et al. Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1. Elife. 5. PMID 27595565 DOI: 10.7554/Elife.17101  0.68
2016 Zhang Z, Rothbart SB, Allison DF, Harrison JS, Wang Y, Strahl BD, Wang GG, Song J. Allosteric Regulation of UHRF1 for DNA Methylation Maintenance Biophysical Journal. 110: 513a. DOI: 10.1016/J.Bpj.2015.11.2742  0.688
2016 Cornett EM, Dickson BM, Vaughan RM, Krishnan S, Trievel RC, Strahl BD, Rothbart SB. Substrate Specificity Profiling of Histone-Modifying Enzymes by Peptide Microarray Methods in Enzymology. DOI: 10.1016/bs.mie.2016.01.008  0.595
2015 Cliffe AR, Arbuckle JH, Vogel JL, Geden MJ, Rothbart SB, Cusack CL, Strahl BD, Kristie TM, Deshmukh M. Neuronal Stress Pathway Mediating a Histone Methyl/Phospho Switch Is Required for Herpes Simplex Virus Reactivation. Cell Host & Microbe. 18: 649-58. PMID 26651941 DOI: 10.1016/J.Chom.2015.11.007  0.575
2015 Simon JM, Parker JS, Liu F, Rothbart SB, Ait-Si-Ali S, Strahl BD, Jin J, Davis IJ, Mosley AL, Pattenden SG. A Role for Widely Interspaced Zinc Finger (WIZ) in Retention of the G9a Methyltransferase on Chromatin. The Journal of Biological Chemistry. 290: 26088-102. PMID 26338712 DOI: 10.1074/Jbc.M115.654459  0.618
2015 Zhang ZM, Rothbart SB, Allison DF, Cai Q, Harrison JS, Li L, Wang Y, Strahl BD, Wang GG, Song J. An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1. Cell Reports. 12: 1400-6. PMID 26299963 DOI: 10.1016/J.Celrep.2015.07.046  0.655
2015 Ali M, Daze KD, Strongin DE, Rothbart SB, Rincon-Arano H, Allen HF, Li J, Strahl BD, Hof F, Kutateladze TG. Molecular insight into inhibition of the methylated histone-plant homeodomain complexes by calixarenes. The Journal of Biological Chemistry. PMID 26229108 DOI: 10.1074/Jbc.M115.669333  0.732
2015 Rothbart SB, Dickson BM, Raab JR, Grzybowski AT, Krajewski K, Guo AH, Shanle EK, Josefowicz SZ, Fuchs SM, Allis CD, Magnuson TR, Ruthenburg AJ, Strahl BD. An Interactive Database for the Assessment of Histone Antibody Specificity. Molecular Cell. 59: 502-11. PMID 26212453 DOI: 10.1016/J.Molcel.2015.06.022  0.769
2015 Rothbart SB, Dickson BM, Strahl BD. From histones to ribosomes: a chromatin regulator tangoes with translation. Cancer Discovery. 5: 228-30. PMID 25749972 DOI: 10.1158/2159-8290.Cd-15-0073  0.702
2015 Tong Q, Mazur SJ, Rincon-Arano H, Rothbart SB, Kuznetsov DM, Cui G, Liu WH, Gete Y, Klein BJ, Jenkins L, Mer G, Kutateladze AG, Strahl BD, Groudine M, Appella E, et al. An acetyl-methyl switch drives a conformational change in p53. Structure (London, England : 1993). 23: 322-31. PMID 25651062 DOI: 10.1016/J.Str.2014.12.010  0.558
2015 Perfetti MT, Baughman BM, Dickson BM, Mu Y, Cui G, Mader P, Dong A, Norris JL, Rothbart SB, Strahl BD, Brown PJ, Janzen WP, Arrowsmith CH, Mer G, McBride KM, et al. Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1. Acs Chemical Biology. 10: 1072-81. PMID 25590533 DOI: 10.1021/Cb500956G  0.654
2015 Tong Q, Cui G, Botuyan MV, Rothbart SB, Hayashi R, Musselman CA, Singh N, Appella E, Strahl BD, Mer G, Kutateladze TG. Structural plasticity of methyllysine recognition by the tandem tudor domain of 53BP1. Structure (London, England : 1993). 23: 312-21. PMID 25579814 DOI: 10.1016/J.Str.2014.11.013  0.597
2015 Rothbart SB, Dickson BM, Raab JR, Grzybowski AT, Krajewski K, Guo AH, Shanle EK, Josefowicz SZ, Fuchs SM, Allis CD, Magnuson TR, Ruthenburg AJ, Strahl BD. An Interactive Database for the Assessment of Histone Antibody Specificity Molecular Cell. 59: 502-511. DOI: 10.1016/j.molcel.2015.06.022  0.77
2014 Shanle EK, Rothbart SB, Strahl BD. Chromatin biochemistry enters the next generation of code 'seq-ing'. Nature Methods. 11: 799-800. PMID 25075906 DOI: 10.1038/Nmeth.3044  0.806
2014 Greer EL, Beese-Sims SE, Brookes E, Spadafora R, Zhu Y, Rothbart SB, Aristizábal-Corrales D, Chen S, Badeaux AI, Jin Q, Wang W, Strahl BD, Colaiácovo MP, Shi Y. A histone methylation network regulates transgenerational epigenetic memory in C. elegans. Cell Reports. 7: 113-26. PMID 24685137 DOI: 10.1016/J.Celrep.2014.02.044  0.685
2014 Rothbart SB, Strahl BD. Interpreting the language of histone and DNA modifications. Biochimica Et Biophysica Acta. 1839: 627-43. PMID 24631868 DOI: 10.1016/J.Bbagrm.2014.03.001  0.7
2014 Kim HS, Mukhopadhyay R, Rothbart SB, Silva AC, Vanoosthuyse V, Radovani E, Kislinger T, Roguev A, Ryan CJ, Xu J, Jahari H, Hardwick KG, Greenblatt JF, Krogan NJ, Fillingham JS, et al. Identification of a BET family bromodomain/casein kinase II/TAF-containing complex as a regulator of mitotic condensin function. Cell Reports. 6: 892-905. PMID 24565511 DOI: 10.1016/J.Celrep.2014.01.029  0.583
2014 Klein BJ, Piao L, Xi Y, Rincon-Arano H, Rothbart SB, Peng D, Wen H, Larson C, Zhang X, Zheng X, Cortazar MA, Peña PV, Mangan A, Bentley DL, Strahl BD, et al. The histone-H3K4-specific demethylase KDM5B binds to its substrate and product through distinct PHD fingers. Cell Reports. 6: 325-35. PMID 24412361 DOI: 10.1016/J.Celrep.2013.12.021  0.676
2013 Kinkelin K, Wozniak GG, Rothbart SB, Lidschreiber M, Strahl BD, Cramer P. Structures of RNA polymerase II complexes with Bye1, a chromatin-binding PHF3/DIDO homologue. Proceedings of the National Academy of Sciences of the United States of America. 110: 15277-82. PMID 24003114 DOI: 10.1073/Pnas.1311010110  0.775
2013 Gatchalian J, Fütterer A, Rothbart SB, Tong Q, Rincon-Arano H, Sánchez de Diego A, Groudine M, Strahl BD, Martínez-A C, van Wely KH, Kutateladze TG. Dido3 PHD modulates cell differentiation and division. Cell Reports. 4: 148-58. PMID 23831028 DOI: 10.1016/J.Celrep.2013.06.014  0.595
2013 Ali M, Rincón-Arano H, Zhao W, Rothbart SB, Tong Q, Parkhurst SM, Strahl BD, Deng LW, Groudine M, Kutateladze TG. Molecular basis for chromatin binding and regulation of MLL5. Proceedings of the National Academy of Sciences of the United States of America. 110: 11296-301. PMID 23798402 DOI: 10.1073/Pnas.1310156110  0.642
2013 Rothbart SB, Dickson BM, Ong MS, Krajewski K, Houliston S, Kireev DB, Arrowsmith CH, Strahl BD. Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation. Genes & Development. 27: 1288-98. PMID 23752590 DOI: 10.1101/Gad.220467.113  0.746
2013 Cai L, Rothbart SB, Lu R, Xu B, Chen WY, Tripathy A, Rockowitz S, Zheng D, Patel DJ, Allis CD, Strahl BD, Song J, Wang GG. An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting. Molecular Cell. 49: 571-82. PMID 23273982 DOI: 10.1016/J.Molcel.2012.11.026  0.772
2012 Ali M, Yan K, Lalonde ME, Degerny C, Rothbart SB, Strahl BD, Côté J, Yang XJ, Kutateladze TG. Tandem PHD fingers of MORF/MOZ acetyltransferases display selectivity for acetylated histone H3 and are required for the association with chromatin. Journal of Molecular Biology. 424: 328-38. PMID 23063713 DOI: 10.1016/J.Jmb.2012.10.004  0.715
2012 Rothbart SB, Krajewski K, Nady N, Tempel W, Xue S, Badeaux AI, Barsyte-Lovejoy D, Martinez JY, Bedford MT, Fuchs SM, Arrowsmith CH, Strahl BD. Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation. Nature Structural & Molecular Biology. 19: 1155-60. PMID 23022729 DOI: 10.1038/Nsmb.2391  0.759
2012 Rothbart SB, Krajewski K, Strahl BD, Fuchs SM. Peptide microarrays to interrogate the "histone code". Methods in Enzymology. 512: 107-35. PMID 22910205 DOI: 10.1016/B978-0-12-391940-3.00006-8  0.817
2012 Rothbart SB, Lin S, Britton LM, Krajewski K, Keogh MC, Garcia BA, Strahl BD. Poly-acetylated chromatin signatures are preferred epitopes for site-specific histone H4 acetyl antibodies. Scientific Reports. 2: 489. PMID 22761995 DOI: 10.1038/Srep00489  0.698
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