Dale Greiner - Publications

Affiliations: 
Diabetes University of Massachusetts Medical School, Worcester, MA, United States 

190 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Stadinski BD, Cleveland SB, Brehm MA, Greiner DL, Huseby PG, Huseby ES. I-A β56/57 polymorphisms regulate non-cognate negative selection to CD4 T cell orchestrators of type 1 diabetes. Nature Immunology. PMID 36807641 DOI: 10.1038/s41590-023-01441-0  0.36
2022 Derr AG, Arowosegbe A, Satish B, Redick SD, Qaisar N, Guo Z, Vanderleeden E, Trombly MI, Baer CE, Harlan DM, Greiner DL, Garber M, Wang JP. An Early Islet Transcriptional Signature is Associated with Local Inflammation in Autoimmune Diabetes. Diabetes. PMID 36346618 DOI: 10.2337/db22-0521  0.344
2020 Redick SD, Leehy L, Rittenhouse AR, Blodgett DM, Derr AG, Kucukural A, Garber MG, Shultz LD, Greiner DL, Wang JP, Harlan DM, Bortell R, Jurczyk A. Recovery of viable endocrine-specific cells and transcriptomes from human pancreatic islet-engrafted mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 34: 1901-1911. PMID 31914605 DOI: 10.1096/fj.201901022RR  0.312
2019 Keck JG, Cheng M, Brehm M, Greiner D, Shultz LJ, Rueter J, Ye C. A donor-dependent in vivo model for single agent and drug combination cytokine release syndrome safety evaluation. Journal of Clinical Oncology. 37: 2612-2612. DOI: 10.1200/Jco.2019.37.15_Suppl.2612  0.38
2019 Ye C, Cheng M, Brehm M, Greiner D, Shultz L, Keck JG. Abstract 4990: An in vivo method for determining cancer immunotherapy induced cytokine release syndrome utilizing PBMC humanized mice Cancer Research. 79: 4990-4990. DOI: 10.1158/1538-7445.Am2019-4990  0.393
2019 Ye C, Brehm M, Cheng M, Shultz L, Greiner D, Keck J. Abstract 3902: Increased sensitivity for detecting cytokine release syndrome with cancer immunotherapy using a PBMC humanized NSG-SGM3 mouse model Cancer Research. 79: 3902-3902. DOI: 10.1158/1538-7445.Am2019-3902  0.428
2018 Brehm MA, Kenney LL, Wiles MV, Low BE, Tisch RM, Burzenski L, Mueller C, Greiner DL, Shultz LD. Lack of acute xenogeneic graft- versus-host disease, but retention of T-cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class I and II expression. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201800636R. PMID 30383447 DOI: 10.1096/Fj.201800636R  0.316
2018 Yao L, Cheng M, Aryee K, Kumar P, Walsh N, Greiner D, Shultz L, Liu ET, Brehm M, Keck JG. Abstract 5676: Patient-derived tumor xenografts in humanized NSG-SGM3 mice: An improved immuno-oncology platform Cancer Research. 78: 5676-5676. DOI: 10.1158/1538-7445.Am2018-5676  0.385
2016 Ali R, Babad J, Follenzi A, Gebe JA, Brehm MA, Nepom GT, Shultz LD, Greiner DL, DiLorenzo TP. Genetically Modified Human CD4(+) T Cells Can Be Evaluated In Vivo Without Lethal Graft Versus Host Disease. Immunology. PMID 27124592 DOI: 10.1111/Imm.12613  0.328
2016 Vegas AJ, Veiseh O, Gürtler M, Millman JR, Pagliuca FW, Bader AR, Doloff JC, Li J, Chen M, Olejnik K, Tam HH, Jhunjhunwala S, Langan E, Aresta-Dasilva S, Gandham S, ... ... Greiner DL, et al. Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice. Nature Medicine. PMID 26808346 DOI: 10.1038/Nm.4030  0.303
2015 Presa M, Chen YG, Grier AE, Leiter EH, Brehm MA, Greiner DL, Shultz LD, Serreze DV. The Presence and Preferential Activation of Regulatory T Cells Diminish Adoptive Transfer of Autoimmune Diabetes by Polyclonal Nonobese Diabetic (NOD) T Cell Effectors into NSG versus NOD-scid Mice. Journal of Immunology (Baltimore, Md. : 1950). 195: 3011-9. PMID 26283479 DOI: 10.4049/Jimmunol.1402446  0.383
2015 Gallagher GR, Brehm MA, Finberg RW, Barton BA, Shultz LD, Greiner DL, Bortell R, Wang JP. Viral infection of engrafted human islets leads to diabetes. Diabetes. 64: 1358-69. PMID 25392246 DOI: 10.2337/Db14-1020  0.306
2015 Babad J, Mukherjee G, Follenzi A, Ali R, Roep BO, Shultz LD, Santamaria P, Yang OO, Goldstein H, Greiner DL, DiLorenzo TP. Generation of β cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic mice. Clinical and Experimental Immunology. 179: 398-413. PMID 25302633 DOI: 10.1111/Cei.12465  0.355
2015 Gerstein R, Zhou Z, Zhang H, Evens A, Walsh N, Shultz L, Bortell R, Brehm M, Cerny J, Whalen G, Leonard J, Woda B, Greiner D, Rosmarin AG. Patient-Derived Xenografts (PDX) of B Cell Lymphoma in NSG Mice: A Mouse Avatar for Developing Personalized Medicine Blood. 126: 5408-5408. DOI: 10.1182/Blood.V126.23.5408.5408  0.344
2014 Pagliuca FW, Millman JR, Gürtler M, Segel M, Van Dervort A, Ryu JH, Peterson QP, Greiner D, Melton DA. Generation of functional human pancreatic β cells in vitro. Cell. 159: 428-39. PMID 25303535 DOI: 10.1016/J.Cell.2014.09.040  0.376
2014 Kochupurakkal NM, Kruger AJ, Tripathi S, Zhu B, Adams LT, Rainbow DB, Rossini A, Greiner DL, Sayegh MH, Wicker LS, Guleria I. Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes. Plos One. 9: e89561. PMID 24586872 DOI: 10.1371/journal.pone.0089561  0.557
2014 Knoechel B, Roderick J, Williamson K, Zhu J, Lohr J, Cotton M, Gillespie S, Fernandez D, Ku M, Wang H, Piccioni F, Silver S, Jain M, Pearson D, Kluk M, ... ... Greiner D, et al. Abstract 4782: Epigenetic resistance to Notch inhibition in T cell acute lymphoblastic leukemia Cancer Research. 74: 4782-4782. DOI: 10.1158/1538-7445.Am2014-4782  0.348
2013 Jain N, Miu B, Jiang JK, McKinstry KK, Prince A, Swain SL, Greiner DL, Thomas CJ, Sanderson MJ, Berg LJ, Kang J. CD28 and ITK signals regulate autoreactive T cell trafficking. Nature Medicine. 19: 1632-7. PMID 24270545 DOI: 10.1038/Nm.3393  0.332
2013 Priyadharshini B, Thornley TB, Daniels KA, Cuthbert A, Welsh RM, Greiner DL, Brehm MA. Alloreactive CD8 T cells rescued from apoptosis during co-stimulation blockade by Toll-like receptor stimulation remain susceptible to Fas-induced cell death. Immunology. 138: 322-32. PMID 23190301 DOI: 10.1111/Imm.12044  0.326
2012 Unger WW, Pearson T, Abreu JR, Laban S, van der Slik AR, der Kracht SM, Kester MG, Serreze DV, Shultz LD, Griffioen M, Drijfhout JW, Greiner DL, Roep BO. Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice. Plos One. 7: e49213. PMID 23155466 DOI: 10.1371/journal.pone.0049213  0.354
2012 Liu Z, Cort L, Eberwine R, Herrmann T, Leif JH, Greiner DL, Yahalom B, Blankenhorn EP, Mordes JP. Prevention of type 1 diabetes in the rat with an allele-specific anti-T-cell receptor antibody: Vβ13 as a therapeutic target and biomarker. Diabetes. 61: 1160-8. PMID 22368175 DOI: 10.2337/Db11-0867  0.395
2011 Niens M, Grier AE, Marron M, Kay TWH, Greiner DL, Serreze DV. Prevention of "humanized" diabetogenic CD8 T-cell responses in HLA-transgenic NOD mice by a multipeptide coupled-cell approach Diabetes. 60: 1229-1236. PMID 21346176 DOI: 10.2337/db10-1523  0.379
2011 Jurczyk A, Roy N, Bajwa R, Gut P, Lipson K, Yang C, Covassin L, Racki WJ, Rossini AA, Phillips N, Stainier DY, Greiner DL, Brehm MA, Bortell R, diIorio P. Dynamic glucoregulation and mammalian-like responses to metabolic and developmental disruption in zebrafish. General and Comparative Endocrinology. 170: 334-45. PMID 20965191 DOI: 10.1016/J.Ygcen.2010.10.010  0.465
2011 Kruger AJ, Yang C, Lipson KL, Pino SC, Leif JH, Hogan CM, Whalen BJ, Guberski DL, Lee Y, Unger RH, Greiner DL, Rossini AA, Bortell R. Leptin treatment confers clinical benefit at multiple stages of virally induced type 1 diabetes in BB rats. Autoimmunity. 44: 137-48. PMID 20695765 DOI: 10.3109/08916934.2010.482116  0.619
2011 Przyklenk K, Maynard M, Greiner DL, Whittaker P. Cardioprotection with postconditioning: loss of efficacy in murine models of type-2 and type-1 diabetes. Antioxidants & Redox Signaling. 14: 781-90. PMID 20578962 DOI: 10.1089/Ars.2010.3343  0.304
2010 Kruger AJ, Yang C, Tam SW, Hinerfeld D, Evans JE, Green KM, Leszyk J, Yang K, Guberski DL, Mordes JP, Greiner DL, Rossini AA, Bortell R. Haptoglobin as an early serum biomarker of virus-induced autoimmune type 1 diabetes in biobreeding diabetes resistant and LEW1.WR1 rats. Experimental Biology and Medicine (Maywood, N.J.). 235: 1328-37. PMID 20975081 DOI: 10.1258/Ebm.2010.010150  0.565
2010 Jurczyk A, Pino SC, O'Sullivan-Murphy B, Addorio M, Lidstone EA, Diiorio P, Lipson KL, Standley C, Fogarty K, Lifshitz L, Urano F, Mordes JP, Greiner DL, Rossini AA, Bortell R. A novel role for the centrosomal protein, pericentrin, in regulation of insulin secretory vesicle docking in mouse pancreatic beta-cells. Plos One. 5: e11812. PMID 20676397 DOI: 10.1371/journal.pone.0011812  0.552
2010 Brehm MA, Daniels KA, Priyadharshini B, Thornley TB, Greiner DL, Rossini AA, Welsh RM. Allografts stimulate cross-reactive virus-specific memory CD8 T cells with private specificity. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 10: 1738-48. PMID 20659086 DOI: 10.1111/J.1600-6143.2010.03161.X  0.59
2010 Brehm MA, Bortell R, Diiorio P, Leif J, Laning J, Cuthbert A, Yang C, Herlihy M, Burzenski L, Gott B, Foreman O, Powers AC, Greiner DL, Shultz LD. Human immune system development and rejection of human islet allografts in spontaneously diabetic NOD-Rag1null IL2rgammanull Ins2Akita mice. Diabetes. 59: 2265-70. PMID 20570944 DOI: 10.2337/Db10-0323  0.338
2010 Racki WJ, Covassin L, Brehm M, Pino S, Ignotz R, Dunn R, Laning J, Graves SK, Rossini AA, Shultz LD, Greiner DL. NOD-scid IL2rgamma(null) mouse model of human skin transplantation and allograft rejection. Transplantation. 89: 527-36. PMID 20134397 DOI: 10.1097/TP.0b013e3181c90242  0.549
2010 Brehm MA, Cuthbert A, Yang C, Miller DM, DiIorio P, Laning J, Burzenski L, Gott B, Foreman O, Kavirayani A, Herlihy M, Rossini AA, Shultz LD, Greiner DL. Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation. Clinical Immunology (Orlando, Fla.). 135: 84-98. PMID 20096637 DOI: 10.1016/J.Clim.2009.12.008  0.535
2010 Subramanya S, Kim SS, Abraham S, Yao J, Kumar M, Kumar P, Haridas V, Lee SK, Shultz LD, Greiner D, N M, Shankar P. Targeted delivery of small interfering RNA to human dendritic cells to suppress dengue virus infection and associated proinflammatory cytokine production. Journal of Virology. 84: 2490-501. PMID 20015996 DOI: 10.1128/Jvi.02105-08  0.302
2010 Tirabassi RS, Guberski DL, Blankenhorn EP, Leif JH, Woda BA, Liu Z, Winans D, Greiner DL, Mordes JP. Infection with viruses from several families triggers autoimmune diabetes in LEW*1WR1 rats: prevention of diabetes by maternal immunization. Diabetes. 59: 110-8. PMID 19794063 DOI: 10.2337/Db09-0255  0.306
2010 Jurczyk A, Pino S, O'Sullivan-Murphy B, Addorio M, Lidstone E, DiIorio P, Lipson K, Standley C, Fogarty K, Lifshitz L, Urano F, Doxsey S, Mordes J, Greiner D, Rossini A, et al. A novel role for the centrosome protein, pericentrin, in regulation of insulin granule docking F1000research. 1. DOI: 10.7490/F1000Research.21.1  0.507
2010 Mordes J, Guberski D, Liu Z, Herrmann T, Leif J, Greiner D, Blankenhorn E. Analysis of the Iddm14 Rat Diabetes Susceptibility Locus in Multiple Rat Strains: Identification of a Susceptibility Haplotype in the Tcrb-V13 Gene and Prevention of Diabetes by Depletion of Vbeta13+ T Cells Clinical Immunology. 135: S116. DOI: 10.1016/J.Clim.2010.03.348  0.449
2010 Mordes J, Greiner D, Guberski D, Blankenhorn E, Tirabassi R. Infection with Viruses from Several Families Triggers Autoimmune Diabetes in LEW.1WR1 Rats Clinical Immunology. 135: S111. DOI: 10.1016/J.Clim.2010.03.333  0.382
2009 Blankenhorn EP, Cort L, Greiner DL, Guberski DL, Mordes JP. Virus-induced autoimmune diabetes in the LEW.1WR1 rat requires Iddm14 and a genetic locus proximal to the major histocompatibility complex. Diabetes. 58: 2930-8. PMID 19720792 DOI: 10.2337/Db09-0387  0.303
2009 King MA, Covassin L, Brehm MA, Racki W, Pearson T, Leif J, Laning J, Fodor W, Foreman O, Burzenski L, Chase TH, Gott B, Rossini AA, Bortell R, Shultz LD, ... Greiner DL, et al. Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex. Clinical and Experimental Immunology. 157: 104-18. PMID 19659776 DOI: 10.1111/j.1365-2249.2009.03933.x  0.567
2009 Pino SC, O'Sullivan-Murphy B, Lidstone EA, Yang C, Lipson KL, Jurczyk A, diIorio P, Brehm MA, Mordes JP, Greiner DL, Rossini AA, Bortell R. CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells. Plos One. 4: e5468. PMID 19424493 DOI: 10.1371/Journal.Pone.0005468  0.566
2009 Chopra P, Diiorio P, Pino SC, Wilson SB, Phillips NE, Mordes JP, Rossini AA, Greiner DL, Shultz LD, Bortell R. Failure of alpha-galactosylceramide to prevent diabetes in virus-inducible models of type 1 diabetes in the rat. In Vivo (Athens, Greece). 23: 195-201. PMID 19414403  0.574
2009 Miller DM, Thornley TB, Pearson T, Kruger AJ, Yamazaki M, Shultz LD, Welsh RM, Brehm MA, Rossini AA, Greiner DL. TLR agonists prevent the establishment of allogeneic hematopoietic chimerism in mice treated with costimulation blockade. Journal of Immunology (Baltimore, Md. : 1950). 182: 5547-59. PMID 19380803 DOI: 10.4049/Jimmunol.0802077  0.589
2009 Bishop KD, Harris JE, Mordes JP, Greiner DL, Rossini AA, Czech MP, Phillips NE. Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4(+) T lymphocytes via an interleukin-2-dependent mechanism. Cellular Immunology. 256: 86-91. PMID 19230866 DOI: 10.1016/J.Cellimm.2009.01.008  0.686
2009 Mangada J, Pearson T, Brehm MA, Wicker LS, Peterson LB, Shultz LD, Serreze DV, Rossini AA, Greiner DL. Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice. Diabetes. 58: 165-73. PMID 18984741 DOI: 10.2337/db08-0275  0.591
2009 Subramanya S, Armant M, Kim S, Ye C, Leiberman J, Schultz L, Greiner D, Shankar P. P19-56 LB. Priming with SOCS-1 silenced Dendritic cells induces robust HIV-specific CTL response in a novel HLA-A2 transgenic humanized mouse model Retrovirology. 6. DOI: 10.1186/1742-4690-6-S3-P420  0.344
2008 Miller DM, Rossini AA, Greiner DL. Role of innate immunity in transplantation tolerance. Critical Reviews in Immunology. 28: 403-39. PMID 19166387  0.521
2008 Miller DM, Thornley T, Pearson T, Yamazaki M, Brehm MA, Rossini AA, Greiner DL. TLR agonists abrogate co-stimulation blockade-induced mixed chimerism and transplantation tolerance. Annals of the New York Academy of Sciences. 1150: 149-51. PMID 19120285 DOI: 10.1196/annals.1447.034  0.602
2008 Bortell R, Pino SC, Greiner DL, Zipris D, Rossini AA. Closing the circle between the bedside and the bench: Toll-like receptors in models of virally induced diabetes. Annals of the New York Academy of Sciences. 1150: 112-22. PMID 19120279 DOI: 10.1196/annals.1447.025  0.564
2008 King M, Pearson T, Rossini AA, Shultz LD, Greiner DL. Humanized mice for the study of type 1 diabetes and beta cell function. Annals of the New York Academy of Sciences. 1150: 46-53. PMID 19120266 DOI: 10.1196/annals.1447.009  0.595
2008 Miller DM, Thornley TB, Greiner DL, Rossini AA. Viral infection: a potent barrier to transplantation tolerance. Clinical & Developmental Immunology. 2008: 742810. PMID 18815618 DOI: 10.1155/2008/742810  0.511
2008 Pearson T, Shultz LD, Miller D, King M, Laning J, Fodor W, Cuthbert A, Burzenski L, Gott B, Lyons B, Foreman O, Rossini AA, Greiner DL. Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment. Clinical and Experimental Immunology. 154: 270-84. PMID 18785974 DOI: 10.1111/j.1365-2249.2008.03753.x  0.578
2008 Giassi LJ, Pearson T, Shultz LD, Laning J, Biber K, Kraus M, Woda BA, Schmidt MR, Woodland RT, Rossini AA, Greiner DL. Expanded CD34+ human umbilical cord blood cells generate multiple lymphohematopoietic lineages in NOD-scid IL2rgamma(null) mice. Experimental Biology and Medicine (Maywood, N.J.). 233: 997-1012. PMID 18653783 DOI: 10.3181/0802-RM-70  0.617
2008 Pearson T, Shultz LD, Lief J, Burzenski L, Gott B, Chase T, Foreman O, Rossini AA, Bottino R, Trucco M, Greiner DL. A new immunodeficient hyperglycaemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function. Diabetologia. 51: 1449-56. PMID 18563383 DOI: 10.1007/S00125-008-1057-1  0.54
2008 Pino SC, O'Sullivan-Murphy B, Lidstone EA, Thornley TB, Jurczyk A, Urano F, Greiner DL, Mordes JP, Rossini AA, Bortell R. Protein kinase C signaling during T cell activation induces the endoplasmic reticulum stress response. Cell Stress & Chaperones. 13: 421-34. PMID 18418732 DOI: 10.1007/s12192-008-0038-0  0.532
2008 King M, Pearson T, Shultz LD, Leif J, Bottino R, Trucco M, Atkinson MA, Wasserfall C, Herold KC, Woodland RT, Schmidt MR, Woda BA, Thompson MJ, Rossini AA, Greiner DL. A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene. Clinical Immunology (Orlando, Fla.). 126: 303-14. PMID 18096436 DOI: 10.1016/J.Clim.2007.11.001  0.556
2008 Dash Y, Ramesh M, Greiner D, Shultz LD, Klei TR, Rajan TV. Determinants of memory in experimental filarial infections in mice. Parasite Immunology. 29: 567-74. PMID 17944746 DOI: 10.1111/J.1365-3024.2007.00977.X  0.391
2007 Thornley TB, Phillips NE, Beaudette-Zlatanova BC, Markees TG, Bahl K, Brehm MA, Shultz LD, Kurt-Jones EA, Mordes JP, Welsh RM, Rossini AA, Greiner DL. Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation tolerance. Journal of Immunology (Baltimore, Md. : 1950). 179: 6620-9. PMID 17982052 DOI: 10.4049/Jimmunol.179.10.6620  0.53
2007 Izawa A, Yamaura K, Albin MJ, Jurewicz M, Tanaka K, Clarkson MR, Ueno T, Habicht A, Freeman GJ, Yagita H, Abdi R, Pearson T, Greiner DL, Sayegh MH, Najafian N. A novel alloantigen-specific CD8+PD1+ regulatory T cell induced by ICOS-B7h blockade in vivo. Journal of Immunology (Baltimore, Md. : 1950). 179: 786-96. PMID 17617568 DOI: 10.4049/jimmunol.179.2.786  0.329
2007 Martens GW, Arikan MC, Lee J, Ren F, Greiner D, Kornfeld H. Tuberculosis susceptibility of diabetic mice. American Journal of Respiratory Cell and Molecular Biology. 37: 518-24. PMID 17585110 DOI: 10.1165/Rcmb.2006-0478Oc  0.428
2007 Yamazaki M, Pearson T, Brehm MA, Miller DM, Mangada JA, Markees TG, Shultz LD, Mordes JP, Rossini AA, Greiner DL. Different mechanisms control peripheral and central tolerance in hematopoietic chimeric mice. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 7: 1710-21. PMID 17564635 DOI: 10.1111/j.1600-6143.2007.01839.x  0.608
2007 Blankenhorn EP, Descipio C, Rodemich L, Cort L, Leif JH, Greiner DL, Mordes JP. Refinement of the Iddm4 diabetes susceptibility locus reveals TCRVbeta4 as a candidate gene. Annals of the New York Academy of Sciences. 1103: 128-31. PMID 17376830 DOI: 10.1196/Annals.1394.020  0.361
2007 Rossini AA, Greiner DL. Diabetes research in jeopardy: the extinction of clinical diabetes researchers. Annals of the New York Academy of Sciences. 1103: 33-44. PMID 17376823 DOI: 10.1196/annals.1394.016  0.508
2007 King M, Pearson T, Shultz LD, Leif J, Bottino R, Trucco M, Atkinson M, Wasserfall C, Herold K, Mordes JP, Rossini AA, Greiner DL. Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity Annals of the New York Academy of Sciences. 1103: 90-93. PMID 17376822 DOI: 10.1196/Annals.1394.011  0.533
2007 Shultz LD, Pearson T, King M, Giassi L, Carney L, Gott B, Lyons B, Rossini AA, Greiner DL. Humanized NOD/LtSz-scid IL2 receptor common gamma chain knockout mice in diabetes research. Annals of the New York Academy of Sciences. 1103: 77-89. PMID 17332083 DOI: 10.1196/annals.1394.002  0.579
2007 Zipris D, Lien E, Nair A, Xie JX, Greiner DL, Mordes JP, Rossini AA. TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat. Journal of Immunology (Baltimore, Md. : 1950). 178: 693-701. PMID 17202329  0.587
2007 Brehm MA, Mangada J, Markees TG, Pearson T, Daniels KA, Thornley TB, Welsh RM, Rossini AA, Greiner DL. Rapid quantification of naive alloreactive T cells by TNF-alpha production and correlation with allograft rejection in mice. Blood. 109: 819-26. PMID 16973964 DOI: 10.1182/Blood-2006-03-008219  0.562
2007 King MA, Pearson T, Shultz LD, Leif JH, Bottino R, Trucco M, Atkinson MA, Wasserfall C, Herold KC, Mordes JP, Rossini AA, Greiner DL. Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity Clinical Immunology. 123: 90. DOI: 10.1016/J.Clim.2007.03.374  0.523
2006 Hillebrands JL, Whalen B, Visser JT, Koning J, Bishop KD, Leif J, Rozing J, Mordes JP, Greiner DL, Rossini AA. A regulatory CD4+ T cell subset in the BB rat model of autoimmune diabetes expresses neither CD25 nor Foxp3. Journal of Immunology (Baltimore, Md. : 1950). 177: 7820-32. PMID 17114453 DOI: 10.4049/jimmunol.177.11.7820  0.608
2006 Serreze DV, Osborne MA, Chen YG, Chapman HD, Pearson T, Brehm MA, Greiner DL. Partial versus full allogeneic hemopoietic chimerization is a preferential means to inhibit type 1 diabetes as the latter induces generalized immunosuppression. Journal of Immunology (Baltimore, Md. : 1950). 177: 6675-84. PMID 17082580 DOI: 10.4049/Jimmunol.177.10.6675  0.387
2006 Phillips NE, Greiner DL, Mordes JP, Rossini AA. Costimulatory blockade induces hyporesponsiveness in T cells that recognize alloantigen via indirect antigen presentation. Transplantation. 82: 1085-92. PMID 17060858 DOI: 10.1097/01.tp.0000235521.83772.29  0.599
2006 Morrison AR, Moss J, Stevens LA, Evans JE, Farrell C, Merithew E, Lambright DG, Greiner DL, Mordes JP, Rossini AA, Bortell R. ART2, a T cell surface mono-ADP-ribosyltransferase, generates extracellular poly(ADP-ribose). The Journal of Biological Chemistry. 281: 33363-72. PMID 16931513 DOI: 10.1074/jbc.M607259200  0.492
2006 Masaki H, Appel MC, Leahy L, Leif J, Paquin L, Shultz LD, Mordes JP, Greiner DL, Rossini AA. Anti-mouse CD154 antibody treatment facilitates generation of mixed xenogeneic rat hematopoietic chimerism, prevents wasting disease and prolongs xenograft survival in mice. Xenotransplantation. 13: 224-32. PMID 16756565 DOI: 10.1111/j.1399-3089.2006.00290.x  0.584
2006 Beaudette-Zlatanova BC, Whalen B, Zipris D, Yagita H, Rozing J, Groen H, Benjamin CD, Hunig T, Drexhage HA, Ansari MJ, Leif J, Mordes JP, Greiner DL, Sayegh MH, Rossini AA. Costimulation and autoimmune diabetes in BB rats. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 6: 894-902. PMID 16611325 DOI: 10.1111/J.1600-6143.2005.01227.X  0.671
2006 Thornley TB, Brehm MA, Markees TG, Shultz LD, Mordes JP, Welsh RM, Rossini AA, Greiner DL. TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts. Journal of Immunology (Baltimore, Md. : 1950). 176: 1561-70. PMID 16424185 DOI: 10.4049/Jimmunol.176.3.1561  0.598
2006 Blankenhorn E, Leif J, Rodemich L, Greiner D, Mordes J. Su.16. The Iddm4 Rat Diabetes Susceptibility Locus: Tcrvβ4 As a Candidate Gene Clinical Immunology. 119: S165. DOI: 10.1016/J.Clim.2006.04.443  0.401
2006 Zipris D, Lien E, Nair A, Mordes J, Greiner D, Rossini A. OR.51. A Critical Role for the Innate Immune Response in Virus-Induced Autoimmune Diabetes Clinical Immunology. 119: S23. DOI: 10.1016/J.Clim.2006.04.207  0.588
2005 Mordes JP, Guberski DL, Leif JH, Woda BA, Flanagan JF, Greiner DL, Kislauskis EH, Tirabassi RS. LEW.1WR1 rats develop autoimmune diabetes spontaneously and in response to environmental perturbation. Diabetes. 54: 2727-33. PMID 16123363 DOI: 10.2337/DIABETES.54.9.2727  0.367
2005 Shultz LD, Lyons BL, Burzenski LM, Gott B, Chen X, Chaleff S, Kotb M, Gillies SD, King M, Mangada J, Greiner DL, Handgretinger R. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. Journal of Immunology (Baltimore, Md. : 1950). 174: 6477-89. PMID 15879151 DOI: 10.4049/jimmunol.174.10.6477  0.326
2005 Jaeschke A, Rincón M, Doran B, Reilly J, Neuberg D, Greiner DL, Shultz LD, Rossini AA, Flavell RA, Davis RJ. Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes. Proceedings of the National Academy of Sciences of the United States of America. 102: 6931-5. PMID 15867147 DOI: 10.1073/Pnas.0502143102  0.594
2005 Blankenhorn EP, Rodemich L, Martin-Fernandez C, Leif J, Greiner DL, Mordes JP. The rat diabetes susceptibility locus Iddm4 and at least one additional gene are required for autoimmune diabetes induced by viral infection. Diabetes. 54: 1233-7. PMID 15793267 DOI: 10.2337/Diabetes.54.4.1233  0.349
2005 Gordon EJ, Wicker LS, Peterson LB, Serreze DV, Markees TG, Shultz LD, Rossini AA, Greiner DL, Mordes JP. Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD mice. Diabetes. 54: 107-15. PMID 15616017 DOI: 10.2337/diabetes.54.1.107  0.605
2005 Zipris D, Lien E, Xie JX, Greiner DL, Mordes JP, Rossini AA. TLR activation synergizes with Kilham rat virus infection to induce diabetes in BBDR rats. Journal of Immunology (Baltimore, Md. : 1950). 174: 131-42. PMID 15611235 DOI: 10.4049/jimmunol.174.1.131  0.586
2005 Gyurkocza B, Plescia J, Toke M, Greiner D, Colombo G, Lowry PA, Altieri DC. Antileukemic Activity of Shepherdin, a Novel Targeted Inhibitor of the Survivin-Hsp90 Complex. Blood. 106: 242-242. DOI: 10.1182/Blood.V106.11.242.242  0.326
2004 Markees TG, Pearson T, Cuthbert A, Pearson AL, Shultz LD, Leif J, Phillips NE, Mordes JP, Greiner DL, Rossini AA. Evaluation of donor-specific transfusion sources: unique failure of bone marrow cells to induce prolonged skin allograft survival with anti-CD154 monoclonal antibody. Transplantation. 78: 1601-8. PMID 15591948 DOI: 10.1097/01.TP.0000140847.29917.65  0.59
2004 Harris JE, Bishop KD, Phillips NE, Mordes JP, Greiner DL, Rossini AA, Czech MP. Early growth response gene-2, a zinc-finger transcription factor, is required for full induction of clonal anergy in CD4+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 173: 7331-8. PMID 15585857 DOI: 10.4049/Jimmunol.173.12.7331  0.713
2004 Banuelos SJ, Markees TG, Phillips NE, Appel MC, Cuthbert A, Leif J, Mordes JP, Shultz LD, Rossini AA, Greiner DL. Regulation of skin and islet allograft survival in mice treated with costimulation blockade is mediated by different CD4+ cell subsets and different mechanisms. Transplantation. 78: 660-7. PMID 15371665 DOI: 10.1097/01.TP.0000130449.05412.96  0.585
2004 Banuelos SJ, Shultz LD, Greiner DL, Burzenski LM, Gott B, Lyons BL, Rossini AA, Appel MC. Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1 nullPrf1 null mice Clinical Immunology. 112: 273-283. PMID 15308121 DOI: 10.1016/j.clim.2004.04.006  0.578
2004 Pearson T, Weiser P, Markees TG, Serreze DV, Wicker LS, Peterson LB, Cumisky AM, Shultz LD, Mordes JP, Rossini AA, Greiner DL. Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3. Diabetes. 53: 1972-8. PMID 15277375 DOI: 10.2337/diabetes.53.8.1972  0.584
2004 Mordes JP, Bortell R, Blankenhorn EP, Rossini AA, Greiner DL. Rat models of type 1 diabetes: genetics, environment, and autoimmunity. Ilar Journal / National Research Council, Institute of Laboratory Animal Resources. 45: 278-91. PMID 15229375 DOI: 10.1093/Ilar.45.3.278  0.608
2004 Appel MC, Banuelos SJ, Greiner DL, Shultz LD, Mordes JP, Rossini AA. Prolonged survival of neonatal porcine islet xenografts in mice treated with a donor-specific transfusion and anti-CD154 antibody. Transplantation. 77: 1341-9. PMID 15167588 DOI: 10.1097/01.tp.0000116771.68839.c1  0.603
2004 Todd DJ, Forsberg EM, Greiner DL, Mordes JP, Rossini AA, Bortell R. Deficiencies in gut NK cell number and function precede diabetes onset in BB rats. Journal of Immunology (Baltimore, Md. : 1950). 172: 5356-62. PMID 15100275 DOI: 10.4049/jimmunol.172.9.5356  0.637
2004 Hornum L, DeScipio C, Markholst H, Troutman SA, Novak S, Leif J, Greiner D, Mordes JP, Blankenhorn EP. Comparative mapping of rat Iddm4 to segments on HSA7 and MMU6. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 15: 53-61. PMID 14727142 DOI: 10.1007/S00335-003-3023-Z  0.385
2004 Shultz L, Lyons BL, Burzenski LM, Gott B, Chen X, Chaleff S, Kotb M, Gillies SD, Greiner DL, Handgretinger R. Human Lymphoid and Myeloid Cell Development in NOD/LtSz-scid IL2rγnull Mice Engrafted with Mobilized Human Hematopoietic Stem Cells. Blood. 104: 248-248. DOI: 10.1182/BLOOD.V104.11.248.248  0.338
2003 Pearson T, Markees TG, Serreze DV, Pierce MA, Wicker LS, Peterson LB, Shultz LD, Mordes JP, Rossini AA, Greiner DL. Islet cell autoimmunity and transplantation tolerance: two distinct mechanisms? Annals of the New York Academy of Sciences. 1005: 148-56. PMID 14679049 DOI: 10.1196/annals.1288.016  0.589
2003 Shultz LD, Banuelos S, Lyons B, Samuels R, Burzenski L, Gott B, Lang P, Leif J, Appel M, Rossini A, Greiner DL. NOD/LtSz-Rag1nullPfpnull mice: a new model system with increased levels of human peripheral leukocyte and hematopoietic stem-cell engraftment. Transplantation. 76: 1036-42. PMID 14557749 DOI: 10.1097/01.Tp.0000083041.44829.2C  0.593
2003 Turgeon NA, Banuelos SJ, Shultz LD, Lyons BL, Iwakoshi N, Greiner DL, Mordes JP, Rossini AA, Appel MC. Alloimmune injury and rejection of human skin grafts on human peripheral blood lymphocyte-reconstituted non-obese diabetic severe combined immunodeficient β2-microglobulin-null mice Experimental Biology and Medicine. 228: 1096-1104. PMID 14530522  0.607
2003 Pearson T, Markees TG, Serreze DV, Pierce MA, Wicker LS, Peterson LB, Shultz LD, Mordes JP, Rossini AA, Greiner DL. Genetic separation of the transplantation tolerance and autoimmune phenotypes in NOD mice. Reviews in Endocrine & Metabolic Disorders. 4: 255-61. PMID 14501176 DOI: 10.1023/A:1025152312496  0.527
2003 Seung E, Mordes JP, Rossini AA, Greiner DL. Hematopoietic chimerism and central tolerance created by peripheral-tolerance induction without myeloablative conditioning. The Journal of Clinical Investigation. 112: 795-808. PMID 12952928 DOI: 10.1172/JCI18599  0.584
2003 Pandarpurkar M, Wilson-Fritch L, Corvera S, Markholst H, Hornum L, Greiner DL, Mordes JP, Rossini AA, Bortell R. Ian4 is required for mitochondrial integrity and T cell survival. Proceedings of the National Academy of Sciences of the United States of America. 100: 10382-7. PMID 12930893 DOI: 10.1073/Pnas.1832170100  0.536
2003 Seung E, Mordes JP, Greiner DL, Rossini AA. Induction of tolerance for islet transplantation for type 1 diabetes. Current Diabetes Reports. 3: 329-35. PMID 12866997 DOI: 10.1007/s11892-003-0026-9  0.593
2003 Pearson T, Markees TG, Serreze DV, Pierce MA, Marron MP, Wicker LS, Peterson LB, Shultz LD, Mordes JP, Rossini AA, Greiner DL. Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice. Journal of Immunology (Baltimore, Md. : 1950). 171: 185-95. PMID 12816997  0.615
2003 Brehm MA, Markees TG, Daniels KA, Greiner DL, Rossini AA, Welsh RM. Direct visualization of cross-reactive effector and memory allo-specific CD8 T cells generated in response to viral infections. Journal of Immunology (Baltimore, Md. : 1950). 170: 4077-86. PMID 12682237 DOI: 10.4049/Jimmunol.170.8.4077  0.571
2003 Zipris D, Hillebrands JL, Welsh RM, Rozing J, Xie JX, Mordes JP, Greiner DL, Rossini AA. Infections that induce autoimmune diabetes in BBDR rats modulate CD4+CD25+ T cell populations. Journal of Immunology (Baltimore, Md. : 1950). 170: 3592-602. PMID 12646622 DOI: 10.4049/Jimmunol.170.7.3592  0.621
2003 Phillips NE, Markees TG, Mordes JP, Greiner DL, Rossini AA. Blockade of CD40-mediated signaling is sufficient for inducing islet but not skin transplantation tolerance. Journal of Immunology (Baltimore, Md. : 1950). 170: 3015-23. PMID 12626555  0.58
2003 Whalen BJ, Marounek J, Mordes JP, Rossini AA, Greiner DL. Type 1 cytokines polarize thymocytes during T cell development in adult thymus organ cultures. Journal of Autoimmunity. 20: 27-42. PMID 12604310 DOI: 10.1016/S0896-8411(02)00091-4  0.57
2003 Pearson T, Markees TG, Wicker LS, Serreze DV, Peterson LB, Mordes JP, Rossini AA, Greiner DL. NOD congenic mice genetically protected from autoimmune diabetes remain resistant to transplantation tolerance induction. Diabetes. 52: 321-6. PMID 12540603 DOI: 10.2337/diabetes.52.2.321  0.616
2003 Waegell W, Babineau M, Hart M, Dixon K, McRae B, Wallace C, Leach M, Ratnofsky S, Belanger A, Hirst G, Rossini A, Appel M, Mordes J, Greiner D, Banerjee S. A420983, a novel, small molecule inhibitor of LCK prevents allograft rejection. Transplantation Proceedings. 34: 1411-7. PMID 12176420 DOI: 10.1016/S0041-1345(02)02909-3  0.5
2002 Mordes JP, Leif J, Novak S, DeScipio C, Greiner DL, Blankenhorn EP. The iddm4 locus segregates with diabetes susceptibility in congenic WF.iddm4 rats. Diabetes. 51: 3254-62. PMID 12401717 DOI: 10.2337/Diabetes.51.11.3254  0.339
2002 Forman D, Welsh RM, Markees TG, Woda BA, Mordes JP, Rossini AA, Greiner DL. Viral abrogation of stem cell transplantation tolerance causes graft rejection and host death by different mechanisms. Journal of Immunology (Baltimore, Md. : 1950). 168: 6047-56. PMID 12055213 DOI: 10.4049/Jimmunol.168.12.6047  0.562
2001 Iwakoshi NN, Markees TG, Turgeon N, Thornley T, Cuthbert A, Leif J, Phillips NE, Mordes JP, Greiner DL, Rossini AA. Skin allograft maintenance in a new synchimeric model system of tolerance. Journal of Immunology (Baltimore, Md. : 1950). 167: 6623-30. PMID 11714833 DOI: 10.4049/jimmunol.167.11.6623  0.61
2001 Bortell R, Waite DJ, Whalen BJ, Todd D, Leif JH, Lesma E, Moss J, Mordes JP, Rossini AA, Greiner DL. Levels of art2+ cells but not soluble art2 protein correlate with expression of autoimmune diabetes in the BB rat Autoimmunity. 33: 199-211. PMID 11683379 DOI: 10.3109/08916930109008047  0.619
2001 Todd DJ, Greiner DL, Rossini AA, Mordes JP, Bortell R. An atypical population of NK cells that spontaneously secrete IFN-gamma and IL-4 is present in the intraepithelial lymphoid compartment of the rat. Journal of Immunology (Baltimore, Md. : 1950). 167: 3600-9. PMID 11564772 DOI: 10.4049/jimmunol.167.7.3600  0.575
2001 Bortell R, Moss J, McKenna RC, Rigby MR, Niedzwiecki D, Stevens LA, Patton WA, Mordes JP, Greiner DL, Rossini AA. Nicotinamide adenine dinucleotide (NAD) and its metabolites inhibit T lymphocyte proliferation: role of cell surface NAD glycohydrolase and pyrophosphatase activities. Journal of Immunology (Baltimore, Md. : 1950). 167: 2049-59. PMID 11489987 DOI: 10.4049/jimmunol.167.4.2049  0.551
2001 Ballen KK, Valinski H, Greiner D, Shultz LD, Becker PS, Hsieh CC, Stewart FM, Quesenberry PJ. Variables to predict engraftment of umbilical cord blood into immunodeficient mice: usefulness of the non-obese diabetic--severe combined immunodeficient assay. British Journal of Haematology. 114: 211-8. PMID 11472370 DOI: 10.1046/J.1365-2141.2001.02904.X  0.394
2001 Greiner DL, Rossini AA, Mordes JP. Translating data from animal models into methods for preventing human autoimmune diabetes mellitus: caveat emptor and primum non nocere. Clinical Immunology (Orlando, Fla.). 100: 134-43. PMID 11465941 DOI: 10.1006/CLIM.2001.5075  0.561
2001 Whalen BJ, Marounek J, Weiser P, Appel MC, Greiner DL, Mordes JP, Rossini AA. BB rat thymocytes cultured in the presence of islets lose their ability to transfer autoimmune diabetes. Diabetes. 50: 972-9. PMID 11334440 DOI: 10.2337/DIABETES.50.5.972  0.631
2001 Kecha-Kamoun O, Achour I, Martens H, Collette J, Lefebvre PJ, Greiner DL, Geenen V. Thymic expression of insulin-related genes in an animal model of autoimmune type 1 diabetes. Diabetes/Metabolism Research and Reviews. 17: 146-52. PMID 11307180 DOI: 10.1002/dmrr.182  0.309
2001 Gordon EJ, Woda BA, Shultz LD, Rossini AA, Greiner DL, Mordes JP. Rat xenograft survival in mice treated with donor-specific transfusion and anti-CD154 antibody is enhanced by elimination of host CD4+ cells. Transplantation. 71: 319-27. PMID 11213080 DOI: 10.1097/00007890-200101270-00026  0.592
2000 Turgeon NA, Iwakoshi NN, Phillips NE, Meyers WC, Welsh RM, Greiner DL, Mordes JP, Rossini AA. Viral infection abrogates CD8(+) T-cell deletion induced by costimulation blockade. The Journal of Surgical Research. 93: 63-9. PMID 10945944 DOI: 10.1006/Jsre.2000.5962  0.595
2000 Wagar EJ, Cromwell MA, Shultz LD, Woda BA, Sullivan JL, Hesselton RM, Greiner DL. Regulation of human cell engraftment and development of EBV-related lymphoproliferative disorders in Hu-PBL-scid mice. Journal of Immunology (Baltimore, Md. : 1950). 165: 518-27. PMID 10861091 DOI: 10.4049/jimmunol.165.1.518  0.304
2000 Kollet O, Peled A, Byk T, Ben-Hur H, Greiner D, Shultz L, Lapidot T. β2 microglobulin-deficient (B2m(null)) NOD/SCID mice are excellent recipients for studying human stem cell function Blood. 95: 3102-3105. PMID 10807775 DOI: 10.1182/Blood.V95.10.3102.010K14_3102_3105  0.39
2000 Ballen K, Becker PS, Greiner D, Valinski H, Shearin D, Berrios V, Dooner G, Hsieh CC, Wuu J, Shultz L, Cerny J, Leif J, Stewart FM, Quesenberry P. Effect of ex vivo cytokine treatment on human cord blood engraftment in NOD-scid mice British Journal of Haematology. 108: 629-640. PMID 10759723 DOI: 10.1046/J.1365-2141.2000.01865.X  0.331
2000 Shultz LD, Lang PA, Christianson SW, Gott B, Lyons B, Umeda S, Leiter E, Hesselton RA, Wagar EJ, Leif JH, Kollet O, Lapidot T, Greiner DL. NOD/LtSz-Rag1(null) mice: An immunodeficient and radioresistant model for engraftment of human hematolymphoid cells, HIV infection, and adoptive transfer of NOD mouse diabetogenic T cells Journal of Immunology. 164: 2496-2507. PMID 10679087 DOI: 10.4049/Jimmunol.164.5.2496  0.322
2000 Welsh RM, Markees TG, Woda BA, Daniels KA, Brehm MA, Mordes JP, Greiner DL, Rossini AA. Virus-induced abrogation of transplantation tolerance induced by donor-specific transfusion and anti-CD154 antibody. Journal of Virology. 74: 2210-8. PMID 10666251 DOI: 10.1128/Jvi.74.5.2210-2218.2000  0.574
2000 Iwakoshi NN, Mordes JP, Markees TG, Phillips NE, Rossini AA, Greiner DL. Treatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8+ T cells and prolonged graft survival in a CTLA4-dependent manner. Journal of Immunology (Baltimore, Md. : 1950). 164: 512-21. PMID 10605049 DOI: 10.4049/jimmunol.164.1.512  0.581
2000 Iwakoshi NN, Greiner DL, Rossini AA, Mordes JP. Diabetes prone BB rats are severely deficient in natural killer T cells. Autoimmunity. 31: 1-14. PMID 10593564 DOI: 10.3109/08916939908993854  0.647
2000 Seung E, Iwakoshi N, Woda BA, Markees TG, Mordes JP, Rossini AA, Greiner DL. Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD154 antibody: absence of graft-versus-host disease, induction of skin allograft tolerance, and prevention of recurrent autoimmunity in islet-allografted NOD/Lt mice Blood. 95: 2175-2182. DOI: 10.1182/BLOOD.V95.6.2175  0.616
2000 Turgeon NA, Iwakoshi NN, Harland RC, Welsh RM, Greiner DL, Mordes JM, Rossini AA. TREATMENT WITH POLYINOSINIC:POLYCYTIDYLIC ACID (POLY I:C) PREVENTS THE DELETION OF CD8+T CELLS BY COSTIMULATION BLOCKADE INVOLVED IN THE INDUCTION OF ALLOGRAFT TOLERANCE.: Abstract# 718 Transplantation. 69. DOI: 10.1097/00007890-200004271-00718  0.557
2000 Turgeon NA, Iwakoshi NN, Meyers WC, Dahl DM, Shultz LD, Greiner DL, Rossini AA. Human skin allograft rejection in a small animal model Journal of the American College of Surgeons. 191: S97. DOI: 10.1016/S1072-7515(00)00679-7  0.485
1999 Melander A, Olsson J, Lindberg G, Salzman A, Howard T, Stang P, Lydick E, Emslie-Smith A, Boyle DI, Evans JM, Macdonald TM, Bain J, Sullivan F, Juhl C, ... ... Greiner D, et al. 35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999. Diabetologia. 42: A1-A330. PMID 27770183 DOI: 10.1007/Bf03375458  0.365
1999 Martin AM, Maxson MN, Leif J, Mordes JP, Greiner DL, Blankenhorn EP. Diabetes-prone and diabetes-resistant BB rats share a common major diabetes susceptibility locus, iddm4: additional evidence for a "universal autoimmunity locus" on rat chromosome 4. Diabetes. 48: 2138-44. PMID 10535446 DOI: 10.2337/Diabetes.48.11.2138  0.323
1999 Todd D, Singh AJ, Greiner DL, Mordes JP, Rossini AA, Bortell R. A new isolation method for rat intraepithelial lymphocytes Journal of Immunological Methods. 224: 111-127. PMID 10357212 DOI: 10.1016/S0022-1759(99)00015-0  0.583
1999 Markees TG, Serreze DV, Phillips NE, Sorli CH, Gordon EJ, Shultz LD, Noelle RJ, Woda BA, Greiner DL, Mordes JP, Rossini AA. NOD mice have a generalized defect in their response to transplantation tolerance induction. Diabetes. 48: 967-74. PMID 10331399 DOI: 10.2337/Diabetes.48.5.967  0.639
1999 Whalen BJ, Love LC, Mordes JP, Rossini AA, Greiner DL. Intravital dye-labeled diabetogenic rat T cells retain dye, home to the pancreas, and induce diabetes. Transplantation Proceedings. 31: 1611-4. PMID 10331021 DOI: 10.1016/S0041-1345(99)00057-3  0.608
1999 Markees TG, Phillips NE, Gordon EJ, Noelle RJ, Maliszewski C, Mordes JP, Greiner DL, Rossini AA. Prolonged skin allograft survival in mice treated with Flt3-ligand-induced dendritic cells and anti-CD154 monoclonal antibody. Transplantation Proceedings. 31: 884-5. PMID 10083387 DOI: 10.1016/S0041-1345(98)01817-X  0.565
1999 Rossini AA, Mordes JP, Markees TG, Phillips NE, Gordon EJ, Greiner DL. Induction of islet transplantation tolerance using donor specific transfusion and anti-CD154 monoclonal antibody. Transplantation Proceedings. 31: 629-32. PMID 10083269 DOI: 10.1016/S0041-1345(98)01589-9  0.551
1999 Rossini AA, Greiner DL, Mordes JP. Induction of immunologic tolerance for transplantation. Physiological Reviews. 79: 99-141. PMID 9922369 DOI: 10.1152/PHYSREV.1999.79.1.99  0.523
1999 Bortell R, Kanaitsuka T, Stevens LA, Moss J, Mordes JP, Rossini AA, Greiner DL. Molecular and Cellular Biochemistry. 193: 61-68. DOI: 10.1023/A:1006951809531  0.473
1998 Markees T, Phillips N, Gordon E, Noelle RJ, Mordes JP, Greiner DL, Rossini AA. Improved skin allograft tolerance induced by treatment with donor splenocytes and an extended course of anti-CD154 monoclonal antibody. Transplantation Proceedings. 30: 2444-6. PMID 9723531 DOI: 10.1016/S0041-1345(98)00680-0  0.532
1998 Gordon EJ, Markees TG, Phillips NE, Noelle RJ, Shultz LD, Mordes JP, Rossini AA, Greiner DL. Prolonged survival of rat islet and skin xenografts in mice treated with donor splenocytes and anti-CD154 monoclonal antibody. Diabetes. 47: 1199-206. PMID 9703317 DOI: 10.2337/Diab.47.8.1199  0.615
1998 Markees TG, Phillips NE, Gordon EJ, Noelle RJ, Shultz LD, Mordes JP, Greiner DL, Rossini AA. Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA4. The Journal of Clinical Investigation. 101: 2446-55. PMID 9616216 DOI: 10.1172/Jci2703  0.59
1998 Kosuda LL, Whalen B, Greiner DL, Bigazzi PE. Mercury-induced autoimmunity in Brown Norway rats: kinetics of changes in RT6+ T lymphocytes correlated with IgG isotypes of circulating autoantibodies to laminin 1. Toxicology. 125: 215-31. PMID 9570334 DOI: 10.1016/S0300-483X(97)00180-7  0.337
1998 Kosuda LL, Greiner DL, Bigazzi PE. Effects of HgCl2 on the expression of autoimmune responses and disease in diabetes-prone (DP) BB rats. Autoimmunity. 26: 173-87. PMID 9550285 DOI: 10.3109/08916939708994739  0.308
1998 Foy TM, McIlraith M, Masters SR, Dunn JJ, Rossini AA, Shultz LD, Hesselton RA, Wagar EJ, Lipsky PE, Noelle RJ, Greiner DL. Blockade of CD40-CD154 interferes with human T cell engraftment in scid mice. Cell Transplantation. 7: 25-35. PMID 9489760 DOI: 10.1016/S0963-6897(97)00113-9  0.604
1998 Foy TM, Mcilraith M, Masters SR, Dunn JJ, Rossini AA, Shultz LD, Hesselton RAM, Wagar EJ, Lipsky PE, Noelle RJ, Greiner DL. Blockade of Cd40-Cd154 Interferes with Human T cell Engraftment in Scid Mice Cell Transplantation. 7: 25-35. DOI: 10.1177/096368979800700105  0.571
1997 Markees TG, Phillips NE, Noelle RJ, Shultz LD, Mordes JP, Greiner DL, Rossini AA. Prolonged survival of mouse skin allografts in recipients treated with donor splenocytes and antibody to CD40 ligand. Transplantation. 64: 329-35. PMID 9256196 DOI: 10.1097/00007890-199707270-00026  0.56
1997 Malkani S, Nompleggi D, Hansen JW, Greiner DL, Mordes JP, Rossini AA. Dietary cow's milk protein does not alter the frequency of diabetes in the BB rat. Diabetes. 46: 1133-40. PMID 9200647 DOI: 10.2337/diab.46.7.1133  0.574
1997 Greiner DL, Malkani S, Kanaitsuka T, Bortell R, Doukas J, Rigby M, Whalen B, Stevens LA, Moss J, Mordes JP, Rossini AA. The T cell marker RT6 in a rat model of autoimmune diabetes. Advances in Experimental Medicine and Biology. 419: 209-16. PMID 9193656 DOI: 10.1007/978-1-4419-8632-0_26  0.58
1997 Whalen BJ, Doukas J, Mordes JP, Rossini AA, Greiner DL. Induction of insulin-dependent diabetes mellitus in PVG.RT1u rats. Transplantation Proceedings. 29: 1684-5. PMID 9142232 DOI: 10.1016/S0041-1345(97)00015-8  0.575
1997 Moss J, Stevens LA, Cavanaugh E, Okazaki IJ, Bortell R, Kanaitsuka T, Mordes JP, Greiner DL, Rossini AA. Characterization of mouse Rt6.1 NAD:arginine ADP-ribosyltransferase. The Journal of Biological Chemistry. 272: 4342-6. PMID 9020154 DOI: 10.1074/jbc.272.7.4342  0.516
1997 Mordes JP, Bortell R, Doukas J, Rigby M, Whalen B, Zipris D, Greiner DL, Rossini AA. The BB/Wor rat and the balance hypothesis of autoimmunity. Diabetes/Metabolism Reviews. 12: 103-9. PMID 8877279 DOI: 10.1002/(sici)1099-0895(199607)12:2<103::aid-dmr161>3.0.co;2-2  0.514
1996 Zadeh HH, Greiner DL, Wu DY, Tausche F, Goldschneider I. Abnormalities in the export and fate of recent thymic emigrants in diabetes-prone BB/W rats. Autoimmunity. 24: 35-46. PMID 8937686 DOI: 10.3109/08916939608995355  0.366
1996 Rigby MR, Bortell R, Greiner DL, Czech MP, Klarlund JK, Mordes JP, Rossini AA. The rat T-cell surface protein RT6 is associated with src family tyrosine kinases and generates an activation signal. Diabetes. 45: 1419-26. PMID 8826980 DOI: 10.2337/Diab.45.10.1419  0.673
1996 Rossini AA, Parker DC, Phillips NE, Durie FH, Noelle RJ, Mordes JP, Greiner DL. Induction of immunological tolerance to islet allografts. Cell Transplantation. 5: 49-52. PMID 8665076 DOI: 10.1016/0963-6897(95)02010-1  0.603
1996 Mordes JP, Schirf B, Roipko D, Greiner DL, Weiner H, Nelson P, Rossini AA. Oral insulin does not prevent insulin-dependent diabetes mellitus in BB rats. Annals of the New York Academy of Sciences. 778: 418-21. PMID 8611008 DOI: 10.1111/j.1749-6632.1996.tb21161.x  0.542
1996 Rossini AA, Parker DC, Phillips NE, Durie FH, Noelle RJ, Mordes JP, Greiner DL. Induction of Immunological Tolerance to Islet Allografts Cell Transplantation. 5: 49-52. DOI: 10.1177/096368979600500109  0.536
1996 Mordes JP, Bortell R, Doukas J, Rigby M, Whalen B, Zipris D, Greiner DL, Rossini AA. The BB/Wor Rat and the Balance Hypothesis of Autoimmunity Diabetes/Metabolism Reviews. 12: 103-109. DOI: 10.1002/(SICI)1099-0895(199607)12:2<103::AID-DMR157>3.0.CO;2-2  0.514
1995 Rossini AA, Handler ES, Mordes JP, Greiner DL. Human autoimmune diabetes mellitus: lessons from BB rats and NOD mice--Caveat emptor. Clinical Immunology and Immunopathology. 74: 2-9. PMID 7994922 DOI: 10.1006/CLIN.1995.1002  0.614
1995 Whalen BJ, Rossini AA, Mordes JP, Greiner DL. DR-BB rat thymus contains thymocyte populations predisposed to autoreactivity. Diabetes. 44: 963-7. PMID 7622003 DOI: 10.2337/diab.44.8.963  0.617
1995 Serreze DV, Leiter EH, Hanson MS, Christianson SW, Shultz LD, Hesselton RM, Greiner DL. Emv30(null) NOD-scid mice: An improved host for adoptive transfer of autoimmune diabetes and growth of human lymphohematopoietic cells Diabetes. 44: 1392-1398. PMID 7589844 DOI: 10.2337/diab.44.12.1392  0.307
1995 Parker DC, Greiner DL, Phillips NE, Appel MC, Steele AW, Durie FH, Noelle RJ, Mordes JP, Rossini AA. Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand. Proceedings of the National Academy of Sciences of the United States of America. 92: 9560-4. PMID 7568172 DOI: 10.1073/Pnas.92.21.9560  0.595
1994 Serreze DV, Leiter EH, Christianson GJ, Greiner D, Roopenian DC. Major histocompatibility complex class I-deficient NOD-B2mnull mice are diabetes and insulitis resistant. Diabetes. 43: 505-9. PMID 8314025 DOI: 10.2337/Diab.43.3.505  0.459
1994 Gerling IC, Friedman H, Greiner DL, Shultz LD, Leiter EH. Multiple low-dose streptozocin-induced diabetes in NOD-scid/scid mice in the absence of functional lymphocytes. Diabetes. 43: 433-40. PMID 8314017 DOI: 10.2337/diab.43.3.433  0.354
1994 Battan R, Mordes JP, Abreau S, Greiner DL, Handler ES, Rossini AA. Evidence that intrathymic islet transplantation does not prevent diabetes or subsequent islet graft destruction in RT6-depleted, diabetes-resistant BioBreeding/Worcester rats. Transplantation. 57: 731-6. PMID 8140636 DOI: 10.1097/00007890-199403150-00016  0.63
1994 Whalen BJ, Greiner DL, Mordes JP, Rossini AA. Adoptive transfer of autoimmune diabetes mellitus to athymic rats: synergy of CD4+ and CD8+ T cells and prevention by RT6+ T cells. Journal of Autoimmunity. 7: 819-31. PMID 7888038 DOI: 10.1006/jaut.1994.1065  0.646
1993 Tafuri A, Bowers WE, Handler ES, Appel M, Lew R, Greiner D, Mordes JP, Rossini AA. High stimulatory activity of dendritic cells from diabetes-prone BioBreeding/Worcester rats exposed to macrophage-derived factors. The Journal of Clinical Investigation. 91: 2040-8. PMID 8486773 DOI: 10.1172/JCI116426  0.528
1993 Waite DJ, Handler ES, Mordes JP, Rossini AA, Greiner DL. The RT6 rat lymphocyte alloantigen circulates in soluble form Cellular Immunology. 152: 82-95. PMID 8242775 DOI: 10.1006/cimm.1993.1269  0.63
1993 Crisá L, Sarkar P, Waite DJ, Friedrich FH, Koch-Nolte, Rajan TV, Mordes JP, Handler ES, Thiele HG, Rossini AA, Greiner DL. An RT6a gene is transcribed and translated in lymphopenic diabetes-prone BB rats Diabetes. 42: 688-695. PMID 7683289 DOI: 10.2337/diab.42.5.688  0.625
1992 Mojcik CF, Greiner DL, Goldschneider I. Characterization of RT6-bearing rat lymphocytes. II. Developmental relationships of RT6- and RT6+ T cells. Developmental Immunology. 1: 191-201. PMID 1821696 DOI: 10.1155/1991/87067  0.309
1992 Kitagawa Y, Greiner DL, Reynolds CW, Ortaldo JR, Toccafondi R, Handler ES, van der Meide PH, Mordes JP, Rossini AA. Islet cells but not thyrocytes are susceptible to lysis by NK cells. Journal of Autoimmunity. 4: 703-16. PMID 1797021 DOI: 10.1016/0896-8411(91)90167-B  0.578
1991 Handler ES, Mordes JP, McKeever U, Nakamura N, Bernhard J, Greiner DL, Rossini AA. Effects of irradiation on diabetes in the BB/Wor rat. Autoimmunity. 4: 21-30. PMID 2491639 DOI: 10.3109/08916938909034356  0.601
1991 Kosuda LL, Wayne A, Nahounou M, Greiner DL, Bigazzi PE. Reduction of the RT6.2+ subset of T lymphocytes in brown Norway rats with mercury-induced renal autoimmunity. Cellular Immunology. 135: 154-67. PMID 2018977 DOI: 10.1016/0008-8749(91)90262-A  0.32
1991 Rossini AA, Handler ES, Greiner DL, Mordes JP. Insulin dependent diabetes mellitus hypothesis of autoimmunity. Autoimmunity. 8: 221-35. PMID 1932509 DOI: 10.3109/08916939108997110  0.553
1991 Greiner DL, Shultz LD, Rossini AA, Mordes JP, Handler ES, Rajan TV. Recapitulation of normal and abnormal BB rat immune system development in scid mouse/rat lymphohemopoietic chimeras. The Journal of Clinical Investigation. 88: 717-9. PMID 1864981 DOI: 10.1172/JCI115359  0.601
1991 Gottlieb PA, Handler ES, Appel MC, Greiner DL, Mordes JP, Rossini AA. Insulin treatment prevents diabetes mellitus but not thyroiditis in RT6-depleted diabetes resistant BB/Wor rats. Diabetologia. 34: 296-300. PMID 1864483 DOI: 10.1007/BF00404999  0.599
1991 Greiner DL, Angelillo M, Wayne AL, Fitzgerald KM, Rozenski D, Cutler LS. Experimental autoallergic sialadenitis in the LEW rat. III. Role of CD4+ T cells in EAS induction. Cellular Immunology. 135: 354-9. PMID 1828009 DOI: 10.1016/0008-8749(91)90280-O  0.32
1991 Woda BA, Handler ES, Greiner DL, Reynolds C, Mordes JP, Rossini AA. T-lymphocyte requirement for diabetes in RT6-depleted diabetes-resistant BB rats. Diabetes. 40: 423-8. PMID 1707018 DOI: 10.2337/diab.40.4.423  0.658
1991 Thomas VA, Woda BA, Handler ES, Greiner DL, Mordes JP, Rossini AA. Altered expression of diabetes in BB/Wor rats by exposure to viral pathogens. Diabetes. 40: 255-8. PMID 1703973 DOI: 10.2337/diab.40.2.255  0.605
1990 Rossini AA, Mordes JP, Greiner DL. The pathogenesis of autoimmune diabetes mellitus. Current Opinion in Immunology. 2: 598-603. PMID 2700903 DOI: 10.1016/0952-7915(90)90017-B  0.621
1990 Lefkowith J, Schreiner G, Cormier J, Handler ES, Driscoll HK, Greiner D, Mordes JP, Rossini AA. Prevention of diabetes in the BB rat by essential fatty acid deficiency. Relationship between physiological and biochemical changes. The Journal of Experimental Medicine. 171: 729-43. PMID 2307932 DOI: 10.1084/Jem.171.3.729  0.627
1990 McKeever U, Mordes JP, Greiner DL, Appel MC, Rozing J, Handler ES, Rossini AA. Adoptive transfer of autoimmune diabetes and thyroiditis to athymic rats. Proceedings of the National Academy of Sciences of the United States of America. 87: 7618-22. PMID 2217193 DOI: 10.1073/PNAS.87.19.7618  0.631
1990 Crisá L, Greiner DL, Mordes JP, MacDonald RG, Handler ES, Czech MP, Rossini AA. Biochemical studies of RT6 alloantigens in BB/wor and normal rats: Evidence for intact unexpressed RT6a structural gene in diabetes-prone BB rats Diabetes. 39: 1279-1288. PMID 2210079 DOI: 10.2337/Diab.39.10.1279  0.696
1990 Nakamura N, Woda BA, Tafuri A, Greiner DL, Reynolds CW, Ortaldo J, Chick W, Handler ES, Mordes JP, Rossini AA. Intrinsic cytotoxicity of natural killer cells to pancreatic islets in vitro. Diabetes. 39: 836-43. PMID 2191887 DOI: 10.2337/diab.39.7.836  0.626
1990 Gottlieb PA, Berrios JP, Mariani G, Handler ES, Greiner D, Mordes JP, Rossini AA. Autoimmune destruction of islets transplanted into RT6-depleted diabetes-resistant BB/Wor rats. Diabetes. 39: 643-5. PMID 1970541 DOI: 10.2337/Diab.39.5.643  0.668
1989 Greiner DL, Angelillo M, Mordes JP, Handler ES, Mojcik CF, Nakamura N, Rossini AA. Regulatory T cell control of autoimmune destruction of beta cells in the BB rat. Advances in Experimental Medicine and Biology. 246: 379-85. PMID 3266909 DOI: 10.1007/978-1-4684-5616-5_46  0.55
1989 Burstein D, Mordes JP, Greiner DL, Stein D, Nakamura N, Handler ES, Rossini AA. Prevention of diabetes in BB/Wor rat by single transfusion of spleen cells. Parameters that affect degree of protection. Diabetes. 38: 24-30. PMID 2642432 DOI: 10.2337/diab.38.1.24  0.646
1988 Nakano K, Mordes JP, Handler ES, Greiner DL, Rossini AA. Role of host immune system in BB/Wor rat. Predisposition to diabetes resides in bone marrow. Diabetes. 37: 520-5. PMID 3282942 DOI: 10.2337/diab.37.5.520  0.606
1988 Mojcik CF, Greiner DL, Medlock ES, Komschlies KL, Goldschneider I. Characterization of RT6 bearing rat lymphocytes. I. Ontogeny of the RT6+ subset. Cellular Immunology. 114: 336-46. PMID 3260542 DOI: 10.1016/0008-8749(88)90326-7  0.309
1987 Greiner DL, Mordes JP, Handler ES, Angelillo M, Nakamura N, Rossini AA. Depletion of RT6.1+ T lymphocytes induces diabetes in resistant biobreeding/Worcester (BB/W) rats. The Journal of Experimental Medicine. 166: 461-75. PMID 3496416 DOI: 10.1084/JEM.166.2.461  0.638
1987 Mordes JP, Gallina DL, Handler ES, Greiner DL, Nakamura N, Pelletier A, Rossini AA. Transfusions enriched for W3/25+ helper/inducer T lymphocytes prevent spontaneous diabetes in the BB/W rat. Diabetologia. 30: 22-6. PMID 2952538 DOI: 10.1007/BF01788902  0.644
1986 Rossini AA, Mordes JP, Greiner DL, Nakano K, Appel MC, Handler ES. Spleen cell transfusion in the Bio-Breeding/Worcester rat. Prevention of diabetes, major histocompatibility complex restriction, and long-term persistence of transfused cells. The Journal of Clinical Investigation. 77: 1399-401. PMID 3958191 DOI: 10.1172/JCI112448  0.637
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