| Year |
Citation |
Score |
| 2024 |
Kambhampati S, Hubbard AH, Koley S, Gomez JD, Marsolais F, Evans BS, Young JD, Allen DK. SIMPEL: using stable isotopes to elucidate dynamics of context specific metabolism. Communications Biology. 7: 172. PMID 38347116 DOI: 10.1038/s42003-024-05844-z |
0.391 |
|
| 2023 |
Wang B, Zuniga C, Guarnieri MT, Zengler K, Betenbaugh M, Young JD. Metabolic engineering of Synechococcus elongatus 7942 for enhanced sucrose biosynthesis. Metabolic Engineering. PMID 37678664 DOI: 10.1016/j.ymben.2023.09.002 |
0.379 |
|
| 2023 |
Sacco SA, McAtee Pereira AG, Trenary I, Smith KD, Betenbaugh MJ, Young JD. Overexpression of peroxisome proliferator-activated receptor γ co-activator-1⍺ (PGC-1⍺) in Chinese hamster ovary cells increases oxidative metabolism and IgG productivity. Metabolic Engineering. PMID 37473833 DOI: 10.1016/j.ymben.2023.07.005 |
0.361 |
|
| 2023 |
Babele PK, Srivastava A, Young JD. Metabolic flux phenotyping of secondary metabolism in cyanobacteria. Trends in Microbiology. PMID 37331829 DOI: 10.1016/j.tim.2023.05.005 |
0.397 |
|
| 2022 |
Wang B, Young JD. C-Isotope-Assisted Assessment of Metabolic Quenching During Sample Collection from Suspension Cell Cultures. Analytical Chemistry. PMID 35613318 DOI: 10.1021/acs.analchem.1c05338 |
0.33 |
|
| 2022 |
Sacco SA, Tuckowski AM, Trenary I, Kraft L, Betenbaugh MJ, Young JD, Smith KD. Attenuation of glutamine synthetase selection marker improves product titer and reduces glutamine overflow in Chinese hamster ovary cells. Biotechnology and Bioengineering. PMID 35312045 DOI: 10.1002/bit.28084 |
0.302 |
|
| 2021 |
Rahim M, Ragavan M, Deja S, Merritt ME, Burgess SC, Young JD. INCA 2.0: A tool for integrated, dynamic modeling of NMR- and MS-based isotopomer measurements and rigorous metabolic flux analysis. Metabolic Engineering. 69: 275-285. PMID 34965470 DOI: 10.1016/j.ymben.2021.12.009 |
0.318 |
|
| 2021 |
Rahim M, Hasenour CM, Bednarski TK, Hughey CC, Wasserman DH, Young JD. Multitissue 2H/13C flux analysis reveals reciprocal upregulation of renal gluconeogenesis in hepatic PEPCK-C-knockout mice. Jci Insight. 6. PMID 34156032 DOI: 10.1172/jci.insight.149278 |
0.332 |
|
| 2021 |
Bednarski TK, Rahim M, Young JD. In vivoH/C flux analysis in metabolism research. Current Opinion in Biotechnology. 71: 1-8. PMID 34048994 DOI: 10.1016/j.copbio.2021.04.005 |
0.387 |
|
| 2021 |
Deja S, Kucejova B, Fu X, Browning JD, Young JD, Burgess S. In Vivo Estimation of Ketogenesis Using Metabolic Flux Analysis-Technical Aspects and Model Interpretation. Metabolites. 11. PMID 33924948 DOI: 10.3390/metabo11050279 |
0.304 |
|
| 2020 |
Pannala VR, Estes SK, Rahim M, Trenary I, O'Brien TP, Shiota C, Printz RL, Reifman J, Shiota M, Young JD, Wallqvist A. Toxicant-Induced Metabolic Alterations in Lipid and Amino Acid Pathways Are Predictive of Acute Liver Toxicity in Rats. International Journal of Molecular Sciences. 21. PMID 33158035 DOI: 10.3390/ijms21218250 |
0.313 |
|
| 2020 |
Hasenour CM, Rahim M, Young JD. In Vivo Estimates of Liver Metabolic Flux Assessed by C-Propionate and C-Lactate Are Impacted by Tracer Recycling and Equilibrium Assumptions. Cell Reports. 32: 107986. PMID 32755580 DOI: 10.1016/J.Celrep.2020.107986 |
0.431 |
|
| 2020 |
Pannala VR, Estes SK, Rahim M, Trenary I, O'Brien TP, Shiota C, Printz RL, Reifman J, Oyama T, Shiota M, Young JD, Wallqvist A. Mechanism-based identification of plasma metabolites associated with liver toxicity. Toxicology. 152493. PMID 32479839 DOI: 10.1016/J.Tox.2020.152493 |
0.404 |
|
| 2020 |
Potter AD, Butrico CE, Ford CA, Curry JM, Trenary IA, Tummarakota SS, Hendrix AS, Young JD, Cassat JE. Host nutrient milieu drives an essential role for aspartate biosynthesis during invasive infection. Proceedings of the National Academy of Sciences of the United States of America. PMID 32414924 DOI: 10.1073/Pnas.1922211117 |
0.379 |
|
| 2020 |
Cheah YE, Xu Y, Sacco SA, Babele PK, Zheng AO, Johnson CH, Young JD. Systematic identification and elimination of flux bottlenecks in the aldehyde production pathway of Synechococcus elongatus PCC 7942. Metabolic Engineering. PMID 32222320 DOI: 10.1016/J.Ymben.2020.03.007 |
0.466 |
|
| 2020 |
Bosma KJ, Rahim M, Singh K, Goleva SB, Wall ML, Xia J, Syring KE, Oeser JK, Poffenberger G, McGuinness OP, Means AL, Powers AC, Lee WH, Davis LK, Young JD, et al. Pancreatic Islet Beta Cell-Specific Deletion of G6pc2 Reduces Fasting Blood Glucose. Journal of Molecular Endocrinology. PMID 32213654 DOI: 10.1530/Jme-20-0031 |
0.308 |
|
| 2020 |
Hasenour CM, Kennedy AJ, Bednarski T, Trenary IA, Eudy BJ, DaSilva RP, Boyd KL, Young JD. Vitamin E does not prevent Western diet-induced NASH progression and increases metabolic flux dysregulation in mice. Journal of Lipid Research. PMID 32086244 DOI: 10.1194/Jlr.Ra119000183 |
0.425 |
|
| 2020 |
Bednarski T, Rahim M, Young J. 74-OR: The Effect of SERCA2 Activation on Liver Metabolism and Diet-Induced Steatohepatitis in Mice Diabetes. 69. DOI: 10.2337/Db20-74-Or |
0.356 |
|
| 2020 |
Deja S, Duarte J, Fletcher JA, Kucejova B, Fu X, Vale G, Young J, Browning J, Burgess SC. 368-OR: Activation of Hepatic Gluconeogenesis Is Required to Suppress DNL and Stimulate Ketogenesis during Fasting Diabetes. 69. DOI: 10.2337/Db20-368-Or |
0.4 |
|
| 2020 |
Bednarski TK, Rahim M, Trenary I, Young JD. The effect of SERCA2 activation on liver metabolism during acute lipotoxicity
in vivo The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.06408 |
0.4 |
|
| 2019 |
Deja S, Fu X, Fletcher JA, Kucejova B, Browning JD, Young JD, Burgess SC. Simultaneous tracers and a unified model of positional and mass isotopomers for quantification of metabolic flux in liver. Metabolic Engineering. PMID 31891762 DOI: 10.1016/J.Ymben.2019.12.005 |
0.437 |
|
| 2019 |
Allen DK, Young JD. Tracing metabolic flux through time and space with isotope labeling experiments. Current Opinion in Biotechnology. 64: 92-100. PMID 31864070 DOI: 10.1016/J.Copbio.2019.11.003 |
0.458 |
|
| 2019 |
Babele PK, Young JD. Applications of stable isotope-based metabolomics and fluxomics toward synthetic biology of cyanobacteria. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. e1472. PMID 31816180 DOI: 10.1002/Wsbm.1472 |
0.501 |
|
| 2019 |
Pannala VR, Vinnakota KC, Estes SK, Trenary I, OˈBrien TP, Printz RL, Papin JA, Reifman J, Oyama T, Shiota M, Young JD, Wallqvist A. Genome-scale model-based identification of metabolite indicators for early detection of kidney toxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 31722432 DOI: 10.1093/Toxsci/Kfz228 |
0.394 |
|
| 2019 |
Pannala VR, Vinnakota KC, Rawls KD, Estes SK, O'Brien TP, Printz RL, Papin JA, Reifman J, Shiota M, Young JD, Wallqvist A. Mechanistic identification of biofluid metabolite changes as markers of acetaminophen-induced liver toxicity in rats. Toxicology and Applied Pharmacology. PMID 30974156 DOI: 10.1016/J.Taap.2019.04.001 |
0.388 |
|
| 2019 |
Vinnakota KC, Pannala VR, Wall ML, Rahim M, Estes SK, Trenary I, O'Brien TP, Printz RL, Reifman J, Shiota M, Young JD, Wallqvist A. Network Modeling of Liver Metabolism to Predict Plasma Metabolite Changes During Short-Term Fasting in the Laboratory Rat. Frontiers in Physiology. 10: 161. PMID 30881311 DOI: 10.3389/Fphys.2019.00161 |
0.422 |
|
| 2019 |
BEDNARSKI T, RAHIM M, YOUNG J. 285-LB: Short-Term Effect of Saturated and Monounsaturated Fatty Acids on Hepatic Energy Metabolism Diabetes. 68: 285-LB. DOI: 10.2337/Db19-285-Lb |
0.389 |
|
| 2018 |
Egnatchik RA, Leamy AK, Sacco SA, Cheah YE, Shiota M, Young JD. Glutamate-oxaloacetate transaminase activity promotes palmitate lipotoxicity in rat hepatocytes by enhancing anaplerosis and citric acid cycle flux. The Journal of Biological Chemistry. PMID 30563841 DOI: 10.1074/Jbc.Ra118.004869 |
0.377 |
|
| 2018 |
Pannala VR, Wall ML, Estes SK, Trenary I, O'Brien TP, Printz RL, Vinnakota KC, Reifman J, Shiota M, Young JD, Wallqvist A. Metabolic network-based predictions of toxicant-induced metabolite changes in the laboratory rat. Scientific Reports. 8: 11678. PMID 30076366 DOI: 10.1038/S41598-018-30149-7 |
0.4 |
|
| 2018 |
Ji X, Qian J, Rahman SMJ, Siska PJ, Zou Y, Harris BK, Hoeksema MD, Trenary IA, Heidi C, Eisenberg R, Rathmell JC, Young JD, Massion PP. xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression. Oncogene. PMID 29789716 DOI: 10.1038/S41388-018-0307-Z |
0.357 |
|
| 2018 |
Fensterheim BA, Young JD, Luan L, Kleinbard RR, Stothers CL, Patil NK, McAtee-Pereira AG, Guo Y, Trenary I, Hernandez A, Fults JB, Williams DL, Sherwood ER, Bohannon JK. The TLR4 Agonist Monophosphoryl Lipid A Drives Broad Resistance to Infection via Dynamic Reprogramming of Macrophage Metabolism. Journal of Immunology (Baltimore, Md. : 1950). PMID 29686054 DOI: 10.4049/Jimmunol.1800085 |
0.364 |
|
| 2018 |
Cheah YE, Young JD. Isotopically nonstationary metabolic flux analysis (INST-MFA): putting theory into practice. Current Opinion in Biotechnology. 54: 80-87. PMID 29522915 DOI: 10.1016/J.Copbio.2018.02.013 |
0.464 |
|
| 2018 |
Pereira AGM, Walther JL, Hollenbach M, Young JD. 13 C flux analysis reveals that rebalancing medium amino acid composition can reduce ammonia production while preserving central carbon metabolism of CHO cell cultures. Biotechnology Journal. PMID 29405605 DOI: 10.1002/Biot.201700518 |
0.462 |
|
| 2018 |
Williams IM, Valenzuela FA, Kahl SD, Ramkrishna D, Mezo AR, Young JD, Wells KS, Wasserman DH. Insulin exits skeletal muscle capillaries by fluid-phase transport. The Journal of Clinical Investigation. PMID 29309051 DOI: 10.1172/Jci94053 |
0.456 |
|
| 2018 |
HASENOUR C, RAHIM M, YOUNG J. Assessment and Expansion of Models for13C-Metabolic Flux Analysis (MFA) In Vivo Diabetes. 67: 258-LB. DOI: 10.2337/Db18-258-Lb |
0.48 |
|
| 2018 |
HASENOUR C, YOUNG J. Vitamin E Supplementation during Nonalcoholic Steatohepatitis (NASH) Pathogenesis in High-Sucrose, High-Fat-Fed Genetically Obese Mice Diabetes. 67: 257-LB. DOI: 10.2337/Db18-257-Lb |
0.377 |
|
| 2018 |
DEJA S, FLETCHER JA, KUCEJOVA B, FU X, YOUNG J, BURGESS SC. Simultaneous2H and13C Metabolic Flux Analysis of Liver Metabolism Using NMR and GC-MS—Methods Validation and New Applications Diabetes. 67: 1876-P. DOI: 10.2337/Db18-1876-P |
0.465 |
|
| 2018 |
Rahman J, Ji X, Patel C, Young J, Massion PP. Abstract IA06: Molecular mechanisms of lung cancer development: Between metabolic reprogramming and genomic instability in the field of cancerization Clinical Cancer Research. 24. DOI: 10.1158/1557-3265.Aacriaslc18-Ia06 |
0.37 |
|
| 2018 |
Templeton N, Young JD. Biochemical and metabolic engineering approaches to enhance production of therapeutic proteins in animal cell cultures Biochemical Engineering Journal. 136: 40-50. DOI: 10.1016/J.Bej.2018.04.008 |
0.376 |
|
| 2017 |
Hughey CC, James FD, Bracy DP, Donahue EP, Young JD, Viollet B, Foretz M, Wasserman DH. Loss of hepatic AMP-activated protein kinase impedes the rate of glycogenolysis but not gluconeogenic fluxes in exercising mice. The Journal of Biological Chemistry. PMID 29038293 DOI: 10.1074/Jbc.M117.811547 |
0.365 |
|
| 2017 |
Faubert B, Li KY, Cai L, Hensley CT, Kim J, Zacharias LG, Yang C, Do QN, Doucette S, Burguete D, Li H, Huet G, Yuan Q, Wigal T, Butt Y, ... ... Young JD, et al. Lactate Metabolism in Human Lung Tumors. Cell. 171: 358-371.e9. PMID 28985563 DOI: 10.1016/J.Cell.2017.09.019 |
0.403 |
|
| 2017 |
Ma F, Jazmin LJ, Young JD, Allen DK. Isotopically Nonstationary Metabolic Flux Analysis (INST-MFA) of Photosynthesis and Photorespiration in Plants. Methods in Molecular Biology (Clifton, N.J.). 1653: 167-194. PMID 28822133 DOI: 10.1007/978-1-4939-7225-8_12 |
0.481 |
|
| 2017 |
Egnatchik RA, Brittain EL, Shah AT, Fares WH, Ford HJ, Monahan K, Kang CJ, Kocurek EG, Zhu S, Luong T, Nguyen TT, Hysinger E, Austin ED, Skala MC, Young JD, et al. Dysfunctional BMPR2 signaling drives an abnormal endothelial requirement for glutamine in pulmonary arterial hypertension. Pulmonary Circulation. 7: 186-199. PMID 28680578 DOI: 10.1086/690236 |
0.414 |
|
| 2017 |
Jazmin LJ, Xu Y, Cheah YE, Adebiyi AO, Johnson CH, Young JD. Isotopically nonstationary (13)C flux analysis of cyanobacterial isobutyraldehyde production. Metabolic Engineering. PMID 28479191 DOI: 10.1016/J.Ymben.2017.05.001 |
0.45 |
|
| 2017 |
Hardeman KN, Peng C, Paudel BB, Meyer CT, Luong T, Tyson DR, Young JD, Quaranta V, Fessel JP. Dependence On Glycolysis Sensitizes BRAF-mutated Melanomas For Increased Response To Targeted BRAF Inhibition. Scientific Reports. 7: 42604. PMID 28205616 DOI: 10.1038/Srep42604 |
0.426 |
|
| 2017 |
Templeton N, Smith KD, McAtee-Pereira AG, Dorai H, Betenbaugh MJ, Lang SE, Young JD. Application of (13)C flux analysis to identify high-productivity CHO metabolic phenotypes. Metabolic Engineering. PMID 28122259 DOI: 10.1016/J.Ymben.2017.01.008 |
0.464 |
|
| 2016 |
Rahman SM, Ji X, Zimmerman LJ, Li M, Harris BK, Hoeksema MD, Trenary IA, Zou Y, Qian J, Slebos RJ, Beane J, Spira A, Shyr Y, Eisenberg R, Liebler DC, ... Young JD, et al. The airway epithelium undergoes metabolic reprogramming in individuals at high risk for lung cancer. Jci Insight. 1: e88814. PMID 27882349 DOI: 10.1172/Jci.Insight.88814 |
0.382 |
|
| 2016 |
Hutton JE, Wang X, Zimmerman LJ, Slebos RJ, Trenary IA, Young JD, Li M, Liebler DC. Oncogenic KRAS and BRAF drive metabolic reprogramming in colorectal cancer. Molecular & Cellular Proteomics : McP. PMID 27340238 DOI: 10.1074/Mcp.M116.058925 |
0.467 |
|
| 2016 |
McCloskey D, Young JD, Xu S, Palsson BØ, Feist AM. A modeling method for increased precision and scope of directly measurable fluxes at a genome-scale. Analytical Chemistry. PMID 26981784 DOI: 10.1021/Acs.Analchem.5B04914 |
0.415 |
|
| 2016 |
Hardeman KN, Peng C, Paudel B, Tyson D, Young JD, Quaranta V, Fessel JP. Abstract A43: BRAF-mutated melanomas exhibit distinct metabolic programs that may determine therapeutic response Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Metca15-A43 |
0.44 |
|
| 2015 |
McCloskey D, Young JD, Xu S, Palsson BØ, Feist AM. MID Max: A LC-MS/MS method for measuring the precursor and product mass isotopomer distributions (MIDs) of metabolic intermediates and cofactors for metabolic flux analysis (MFA) applications. Analytical Chemistry. PMID 26666286 DOI: 10.1021/Acs.Analchem.5B03887 |
0.447 |
|
| 2015 |
McAtee AG, Jazmin LJ, Young JD. Application of isotope labeling experiments and (13)C flux analysis to enable rational pathway engineering. Current Opinion in Biotechnology. 36: 50-56. PMID 26319894 DOI: 10.1016/J.Copbio.2015.08.004 |
0.451 |
|
| 2015 |
Whang YM, Park SI, Trenary IA, Egnatchik RA, Fessel JP, Kaufman JM, Carbone DP, Young JD. LKB1 deficiency enhances sensitivity to energetic stress induced by erlotinib treatment in non-small-cell lung cancer (NSCLC) cells. Oncogene. PMID 26119936 DOI: 10.1038/Onc.2015.140 |
0.354 |
|
| 2015 |
Hasenour CM, Wall ML, Ridley DE, Hughey CC, James FD, Wasserman DH, Young JD. Mass spectrometry-based microassay of (2)H and (13)C plasma glucose labeling to quantify liver metabolic fluxes in vivo. American Journal of Physiology. Endocrinology and Metabolism. 309: E191-203. PMID 25991647 DOI: 10.1152/Ajpendo.00003.2015 |
0.414 |
|
| 2015 |
Buescher JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H, Clish CB, DeBerardinis RJ, Feron O, Frezza C, Ghesquiere B, Gottlieb E, Hiller K, Jones RG, Kamphorst JJ, Kibbey RG, ... ... Young JD, et al. A roadmap for interpreting (13)C metabolite labeling patterns from cells. Current Opinion in Biotechnology. 34: 189-201. PMID 25731751 DOI: 10.1016/J.Copbio.2015.02.003 |
0.413 |
|
| 2015 |
Wall ML, Pound LD, Trenary I, O'Brien RM, Young JD. Novel stable isotope analyses demonstrate significant rates of glucose cycling in mouse pancreatic islets. Diabetes. 64: 2129-37. PMID 25552595 DOI: 10.2337/Db14-0745 |
0.31 |
|
| 2015 |
Young JD. Learning from the Steersman: A Natural History of Cybernetic Models Industrial and Engineering Chemistry Research. 54: 10162-10169. DOI: 10.1021/Acs.Iecr.5B01315 |
0.365 |
|
| 2014 |
Young JD. (13)C metabolic flux analysis of recombinant expression hosts. Current Opinion in Biotechnology. 30: 238-45. PMID 25456032 DOI: 10.1016/J.Copbio.2014.10.004 |
0.482 |
|
| 2014 |
Ma F, Jazmin LJ, Young JD, Allen DK. Isotopically nonstationary 13C flux analysis of changes in Arabidopsis thaliana leaf metabolism due to high light acclimation. Proceedings of the National Academy of Sciences of the United States of America. 111: 16967-72. PMID 25368168 DOI: 10.1073/Pnas.1319485111 |
0.43 |
|
| 2014 |
Adebiyi AO, Jazmin LJ, Young JD. (13)C flux analysis of cyanobacterial metabolism. Photosynthesis Research. PMID 25280933 DOI: 10.1007/S11120-014-0045-1 |
0.454 |
|
| 2014 |
Egnatchik RA, Leamy AK, Jacobson DA, Shiota M, Young JD. ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to palmitate overload. Molecular Metabolism. 3: 544-53. PMID 25061559 DOI: 10.1016/J.Molmet.2014.05.004 |
0.346 |
|
| 2014 |
Templeton N, Lewis A, Dorai H, Qian EA, Campbell MP, Smith KD, Lang SE, Betenbaugh MJ, Young JD. The impact of anti-apoptotic gene Bcl-2∆ expression on CHO central metabolism. Metabolic Engineering. 25: 92-102. PMID 25014175 DOI: 10.1016/J.Ymben.2014.06.010 |
0.443 |
|
| 2014 |
Leamy AK, Egnatchik RA, Shiota M, Ivanova PT, Myers DS, Brown HA, Young JD. Enhanced synthesis of saturated phospholipids is associated with ER stress and lipotoxicity in palmitate treated hepatic cells. Journal of Lipid Research. 55: 1478-1488. PMID 24859739 DOI: 10.1194/Jlr.M050237 |
0.342 |
|
| 2014 |
Young JD. INCA: a computational platform for isotopically non-stationary metabolic flux analysis. Bioinformatics (Oxford, England). 30: 1333-5. PMID 24413674 DOI: 10.1093/Bioinformatics/Btu015 |
0.467 |
|
| 2014 |
Egnatchik RA, Leamy AK, Noguchi Y, Shiota M, Young JD. Palmitate-induced activation of mitochondrial metabolism promotes oxidative stress and apoptosis in H4IIEC3 rat hepatocytes. Metabolism: Clinical and Experimental. 63: 283-95. PMID 24286856 DOI: 10.1016/J.Metabol.2013.10.009 |
0.343 |
|
| 2014 |
Jazmin LJ, O'Grady JP, Ma F, Allen DK, Morgan JA, Young JD. Isotopically nonstationary MFA (INST-MFA) of autotrophic metabolism. Methods in Molecular Biology (Clifton, N.J.). 1090: 181-210. PMID 24222417 DOI: 10.1007/978-1-62703-688-7_12 |
0.448 |
|
| 2014 |
Young JD, Allen DK, Morgan JA. Isotopomer measurement techniques in metabolic flux analysis II: mass spectrometry. Methods in Molecular Biology (Clifton, N.J.). 1083: 85-108. PMID 24218212 DOI: 10.1007/978-1-62703-661-0_7 |
0.42 |
|
| 2014 |
McAtee AG, Templeton N, Young JD. Role of Chinese hamster ovary central carbon metabolism in controlling the quality of secreted biotherapeutic proteins Pharmaceutical Bioprocessing. 2: 63-74. DOI: 10.4155/Pbp.13.65 |
0.391 |
|
| 2014 |
Whang YM, Park SI, Trenary IA, Lee C, Kaufman JM, Carbone DP, Young JD. Abstract 1839: LKB1 deficiency enhances sensitivity to energetic stress induced by erlotinib treatment in non-small cell lung cancer (NSCLC) cells Cancer Research. 74: 1839-1839. DOI: 10.1158/1538-7445.Am2014-1839 |
0.37 |
|
| 2013 |
Duckwall CS, Murphy TA, Young JD. Mapping cancer cell metabolism with(13)C flux analysis: Recent progress and future challenges. Journal of Carcinogenesis. 12: 13. PMID 23961260 DOI: 10.4103/1477-3163.115422 |
0.447 |
|
| 2013 |
Young JD. Metabolic flux rewiring in mammalian cell cultures. Current Opinion in Biotechnology. 24: 1108-15. PMID 23726154 DOI: 10.1016/J.Copbio.2013.04.016 |
0.515 |
|
| 2013 |
Jazmin LJ, Young JD. Isotopically nonstationary 13C metabolic flux analysis. Methods in Molecular Biology (Clifton, N.J.). 985: 367-90. PMID 23417813 DOI: 10.1007/978-1-62703-299-5_18 |
0.442 |
|
| 2013 |
Templeton N, Dean J, Reddy P, Young JD. Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed-batch CHO cell culture. Biotechnology and Bioengineering. 110: 2013-24. PMID 23381838 DOI: 10.1002/Bit.24858 |
0.41 |
|
| 2013 |
Allen DK, Young JD. Carbon and nitrogen provisions alter the metabolic flux in developing soybean embryos. Plant Physiology. 161: 1458-75. PMID 23314943 DOI: 10.1104/Pp.112.203299 |
0.409 |
|
| 2013 |
Murphy TA, Young JD. ETA: robust software for determination of cell specific rates from extracellular time courses. Biotechnology and Bioengineering. 110: 1748-58. PMID 23296385 DOI: 10.1002/Bit.24836 |
0.435 |
|
| 2013 |
Leamy AK, Egnatchik RA, Young JD. Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver disease. Progress in Lipid Research. 52: 165-74. PMID 23178552 DOI: 10.1016/J.Plipres.2012.10.004 |
0.323 |
|
| 2013 |
Murphy TA, Dang CV, Young JD. Isotopically nonstationary 13C flux analysis of Myc-induced metabolic reprogramming in B-cells Metabolic Engineering. 15: 206-217. PMID 22898717 DOI: 10.1016/J.Ymben.2012.07.008 |
0.496 |
|
| 2012 |
Strand DW, Jiang M, Murphy TA, Yi Y, Konvinse KC, Franco OE, Wang Y, Young JD, Hayward SW. PPARγ isoforms differentially regulate metabolic networks to mediate mouse prostatic epithelial differentiation. Cell Death & Disease. 3: e361. PMID 22874998 DOI: 10.1038/Cddis.2012.99 |
0.37 |
|
| 2012 |
Young JD, Shastri AA, Stephanopoulos G, Morgan JA. Corrigendum to “Mapping photoautotrophic metabolism with isotopically nonstationary 13C flux analysis” [Metab. Eng. 13 (2011) 656–665] Metabolic Engineering. 14: 185. DOI: 10.1016/J.Ymben.2012.01.005 |
0.448 |
|
| 2011 |
Young JD, Shastri AA, Stephanopoulos G, Morgan JA. Mapping photoautotrophic metabolism with isotopically nonstationary (13)C flux analysis. Metabolic Engineering. 13: 656-65. PMID 21907300 DOI: 10.1016/J.Ymben.2011.08.002 |
0.464 |
|
| 2011 |
Srour O, Young JD, Eldar YC. Fluxomers: a new approach for 13C metabolic flux analysis. Bmc Systems Biology. 5: 129. PMID 21846358 DOI: 10.1186/1752-0509-5-129 |
0.465 |
|
| 2011 |
Noguchi Y, Young JD, Aleman JO, Hansen ME, Kelleher JK, Stephanopoulos G. Tracking cellular metabolomics in lipoapoptosis- and steatosis-developing liver cells. Molecular Biosystems. 7: 1409-19. PMID 21327189 DOI: 10.1039/C0Mb00309C |
0.436 |
|
| 2010 |
Reed JL, Senger RS, Antoniewicz MR, Young JD. Computational approaches in metabolic engineering. Journal of Biomedicine & Biotechnology. 2010: 207414. PMID 21584279 DOI: 10.1155/2010/207414 |
0.42 |
|
| 2010 |
Noguchi Y, Nishikata N, Shikata N, Kimura Y, Aleman JO, Young JD, Koyama N, Kelleher JK, Takahashi M, Stephanopoulos G. Ketogenic essential amino acids modulate lipid synthetic pathways and prevent hepatic steatosis in mice. Plos One. 5: e12057. PMID 20706589 DOI: 10.1371/Journal.Pone.0012057 |
0.35 |
|
| 2009 |
Noguchi Y, Young JD, Aleman JO, Hansen ME, Kelleher JK, Stephanopoulos G. Effect of anaplerotic fluxes and amino acid availability on hepatic lipoapoptosis. The Journal of Biological Chemistry. 284: 33425-36. PMID 19758988 DOI: 10.1074/Jbc.M109.049478 |
0.367 |
|
| 2008 |
Young JD, Henne KL, Morgan JA, Konopka AE, Ramkrishna D. Integrating cybernetic modeling with pathway analysis provides a dynamic, systems-level description of metabolic control. Biotechnology and Bioengineering. 100: 542-59. PMID 18438875 DOI: 10.1002/Bit.21780 |
0.605 |
|
| 2008 |
Young JD, Walther JL, Antoniewicz MR, Yoo H, Stephanopoulos G. An elementary metabolite unit (EMU) based method of isotopically nonstationary flux analysis. Biotechnology and Bioengineering. 99: 686-99. PMID 17787013 DOI: 10.1002/Bit.21632 |
0.369 |
|
| 2008 |
Young JD, Henne KL, Morgan JA, Konopka AE, Ramkrishna D. Integrating cybernetic modeling with pathway analysis provides a dynamic, systems-level description of metabolic control Biotechnology and Bioengineering. 100: 542-559. DOI: 10.1002/bit.21780 |
0.53 |
|
| 2007 |
Young JD, Ramkrishna D. On the matching and proportional laws of cybernetic models Biotechnology Progress. 23: 83-99. PMID 17269675 DOI: 10.1021/Bp060176Q |
0.517 |
|
| 2004 |
Young J, Henne K, Morgan J, Konopka A, Ramkrishna D. Cybernetic modeling of metabolism: Towards a framework for rational design of recombinant organisms Chemical Engineering Science. 59: 5041-5049. DOI: 10.1016/J.Ces.2004.09.037 |
0.618 |
|
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