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Ken H. Cadwell, Ph.D. - Publications

Affiliations: 
2006 University of California, Berkeley, Berkeley, CA, United States 
Area:
Molecular mechanisms of immune evasion in viral infection
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68 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Jang KK, Heaney T, London M, Ding Y, Yeung F, Ercelen D, Chen YH, Axelrad J, Gurunathan S, Marijke Keestra-Gounder A, Griffin ME, Hang HC, Cadwell K. Antimicrobial overproduction sustains intestinal inflammation by inhibiting colonization. Biorxiv : the Preprint Server For Biology. PMID 36778381 DOI: 10.1101/2023.01.29.526128  0.309
2022 Pant A, Yao X, Lavedrine A, Viret C, Dockterman J, Chauhan S, Manjithaya R, Cadwell K, Kufer TA, Kehrl JH, Coers J, Sibley LD, Faure M, Taylor GA, Chauhan S. Interactions of Autophagy and the Immune System in Health and Diseases. Autophagy Reports. 1: 438-515. PMID 37425656 DOI: 10.1080/27694127.2022.2119743  0.325
2022 Matsuzawa-Ishimoto Y, Yao X, Koide A, Ueberheide BM, Axelrad JE, Reis BS, Parsa R, Neil JA, Devlin JC, Rudensky E, Dewan MZ, Cammer M, Blumberg RS, Ding Y, Ruggles KV, ... ... Cadwell K, et al. The γδ IEL effector API5 masks genetic susceptibility to Paneth cell death. Nature. PMID 36198790 DOI: 10.1038/s41586-022-05259-y  0.334
2021 Axelrad JE, Cadwell KH, Colombel JF, Shah SC. The role of gastrointestinal pathogens in inflammatory bowel disease: a systematic review. Therapeutic Advances in Gastroenterology. 14: 17562848211004493. PMID 33868457 DOI: 10.1177/17562848211004493  0.3
2020 Iliev ID, Cadwell K. Effects of Intestinal Fungi and Viruses on Immune Responses and Inflammatory Bowel Diseases. Gastroenterology. 160: 1050-1066. PMID 33347881 DOI: 10.1053/j.gastro.2020.06.100  0.308
2020 Yu S, Balasubramanian I, Laubitz D, Tong K, Bandyopadhyay S, Lin X, Flores J, Singh R, Liu Y, Macazana C, Zhao Y, Béguet-Crespel F, Patil K, Midura-Kiela MT, Wang D, ... ... Cadwell K, et al. Paneth Cell-Derived Lysozyme Defines the Composition of Mucolytic Microbiota and the Inflammatory Tone of the Intestine. Immunity. 53: 398-416.e8. PMID 32814028 DOI: 10.1016/J.Immuni.2020.07.010  0.424
2020 Ozkul C, Ruiz VE, Battaglia T, Xu J, Roubaud-Baudron C, Cadwell K, Perez-Perez GI, Blaser MJ. A single early-in-life antibiotic course increases susceptibility to DSS-induced colitis. Genome Medicine. 12: 65. PMID 32711559 DOI: 10.1186/S13073-020-00764-Z  0.366
2020 Axelrad JE, Cadwell KH, Colombel JF, Shah SC. Systematic review: gastrointestinal infection and incident inflammatory bowel disease. Alimentary Pharmacology & Therapeutics. PMID 32372471 DOI: 10.1111/Apt.15770  0.338
2020 Matsuzawa-Ishimoto Y, Hine A, Shono Y, Rudensky E, Lazrak A, Yeung F, Neil JA, Yao X, Chen YH, Heaney T, Schuster SL, Zwack EE, Axelrad JE, Hudesman D, Tsai JJ, ... ... Cadwell K, et al. An Intestinal Organoid-Based Platform That Recreates Susceptibility to T Cell-Mediated Tissue Injury. Blood. PMID 32232483 DOI: 10.1182/Blood.2019004116  0.382
2020 Yeung F, Chen YH, Lin JD, Leung JM, McCauley C, Devlin JC, Hansen C, Cronkite A, Stephens Z, Drake-Dunn C, Fulmer Y, Shopsin B, Ruggles KV, Round JL, Loke P, ... ... Cadwell K, et al. Altered Immunity of Laboratory Mice in the Natural Environment Is Associated with Fungal Colonization. Cell Host & Microbe. PMID 32209432 DOI: 10.1016/J.Chom.2020.02.015  0.365
2020 Lin JD, Devlin JC, Yeung F, McCauley C, Leung JM, Chen YH, Cronkite A, Hansen C, Drake-Dunn C, Ruggles KV, Cadwell K, Graham AL, Loke P. Rewilding Nod2 and Atg16l1 Mutant Mice Uncovers Genetic and Environmental Contributions to Microbial Responses and Immune Cell Composition. Cell Host & Microbe. PMID 32209431 DOI: 10.1016/J.Chom.2020.03.001  0.347
2020 Keller MD, Ching KL, Liang FX, Dhabaria A, Tam K, Ueberheide BM, Unutmaz D, Torres VJ, Cadwell K. Decoy exosomes provide protection against bacterial toxins. Nature. PMID 32132711 DOI: 10.1038/S41586-020-2066-6  0.402
2020 Xie Y, Zhao Y, Shi L, Li W, Chen K, Li M, Chen X, Zhang H, Li T, Yu MI, Yao X, Shao D, Ke Z, Li J, Chen Y, ... ... Cadwell K, et al. Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer. The Journal of Clinical Investigation. PMID 31961824 DOI: 10.1172/Jci133264  0.398
2020 Keller MD, Torres VJ, Cadwell K. Autophagy and microbial pathogenesis. Cell Death and Differentiation. PMID 31896796 DOI: 10.1038/S41418-019-0481-8  0.444
2020 Martin PK, Cadwell K. Regulation of interferon signaling in response to gut microbes by autophagy. Gut Microbes. 11: 126-134. PMID 31119977 DOI: 10.1080/19490976.2019.1614395  0.361
2020 Dallari S, Heaney T, Rosas-Villegas A, Cadwell K. Abstract PR03: Functional characterization of the enteric animal virome as mediator of host health Cancer Research. 80. DOI: 10.1158/1538-7445.Mvc2020-Pr03  0.431
2020 Axelrad J, Hine A, Devlin J, Loke P, Cadwell K. P832 Gastrointestinal infections are associated with unique gut microbiome signatures in patients with inflammatory bowel disease Journal of Crohns & Colitis. 14. DOI: 10.1093/Ecco-Jcc/Jjz203.960  0.346
2019 Neil JA, Matsuzawa-Ishimoto Y, Kernbauer-Hölzl E, Schuster SL, Sota S, Venzon M, Dallari S, Galvao Neto A, Hine A, Hudesman D, Loke P, Nice TJ, Cadwell K. IFN-I and IL-22 mediate protective effects of intestinal viral infection. Nature Microbiology. PMID 31182797 DOI: 10.1038/S41564-019-0470-1  0.42
2019 Silva HM, Báfica A, Rodrigues-Luiz GF, Chi J, Santos PDA, Reis BS, Hoytema van Konijnenburg DP, Crane A, Arifa RDN, Martin P, Mendes DAGB, Mansur DS, Torres VJ, Cadwell K, Cohen P, et al. Vasculature-associated fat macrophages readily adapt to inflammatory and metabolic challenges. The Journal of Experimental Medicine. PMID 30862706 DOI: 10.1084/Jem.20181049  0.305
2019 Lubkin A, Lee WL, Alonzo F, Wang C, Aligo J, Keller M, Girgis NM, Reyes-Robles T, Chan R, O'Malley A, Buckley P, Vozhilla N, Vasquez MT, Su J, Sugiyama M, ... ... Cadwell K, et al. Staphylococcus aureus Leukocidins Target Endothelial DARC to Cause Lethality in Mice. Cell Host & Microbe. PMID 30799265 DOI: 10.1016/J.Chom.2019.01.015  0.326
2019 Matsuzawa Y, Cadwell K. 14 Autophagy Protein Atg16L1 Prevents Necroptosis In The Intestinal Epithelium Gastroenterology. 156. DOI: 10.1053/J.Gastro.2019.01.183  0.344
2018 Cadwell K. Sugar Turns Bacteria Sweet: A Peace Offering in the Gut. Cell. 175: 36-37. PMID 30241612 DOI: 10.1016/J.Cell.2018.08.053  0.374
2018 Wong SY, Cadwell K. There was collusion: Microbes in inflammatory bowel disease. Plos Pathogens. 14: e1007215. PMID 30235350 DOI: 10.1371/Journal.Ppat.1007215  0.416
2018 Martin PK, Marchiando A, Xu R, Rudensky E, Yeung F, Schuster SL, Kernbauer E, Cadwell K. Autophagy proteins suppress protective type I interferon signalling in response to the murine gut microbiota. Nature Microbiology. PMID 30202015 DOI: 10.1038/S41564-018-0229-0  0.447
2018 Neil JA, Cadwell K. The Intestinal Virome and Immunity Journal of Immunology. 201: 1615-1624. PMID 30181300 DOI: 10.4049/Jimmunol.1800631  0.394
2018 Axelrad JE, Joelson A, Green PHR, Lawlor G, Lichtiger S, Cadwell K, Lebwohl B. Enteric Infections Are Common in Patients with Flares of Inflammatory Bowel Disease. The American Journal of Gastroenterology. PMID 30072777 DOI: 10.1038/S41395-018-0211-8  0.334
2018 Wong SY, Coffre M, Ramanan D, Hines MJ, Gomez LE, Peters LA, Schadt EE, Koralov SB, Cadwell K. B Cell Defects Observed in Knockout Mice Are a Consequence of a Mutation Frequently Found in Inbred Strains. Journal of Immunology (Baltimore, Md. : 1950). PMID 30012848 DOI: 10.4049/Jimmunol.1800014  0.308
2018 Axelrad JE, Lebwohl B, Cuaresma E, Cadwell K, Green PHR, Freedberg DE. Gut colonization with vancomycin-resistant and risk for subsequent enteric infection. Gut Pathogens. 10: 28. PMID 30002733 DOI: 10.1186/S13099-018-0259-4  0.312
2018 Cadwell K. A20 and ABIN-1 team up against intestinal epithelial cell death. Journal of Experimental Medicine. 215: 1771-1773. PMID 29934322 DOI: 10.1084/Jem.20180953  0.317
2018 Wilen CB, Lee S, Hsieh LL, Orchard RC, Desai C, Hykes BL, McAllaster MR, Balce DR, Feehley T, Brestoff JR, Hickey CA, Yokoyama CC, Wang YT, MacDuff DA, Kreamalmayer D, ... ... Cadwell K, et al. Tropism for tuft cells determines immune promotion of norovirus pathogenesis. Science (New York, N.Y.). 360: 204-208. PMID 29650672 DOI: 10.1126/Science.Aar3799  0.414
2018 Wong S, Ramanan D, Cadwell K. 348 - Host-Microbe and Intra-Microbiome Interactions Leading to Small Intestinal Inflammation in a Genetically-Susceptible Host Gastroenterology. 154. DOI: 10.1016/S0016-5085(18)34438-X  0.351
2017 Cadwell K, Debnath J. Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins. The Journal of Cell Biology. PMID 29237720 DOI: 10.1083/Jcb.201706157  0.362
2017 Matsuzawa-Ishimoto Y, Hwang S, Cadwell K. Autophagy and Inflammation. Annual Review of Immunology. PMID 29144836 DOI: 10.1146/Annurev-Immunol-042617-053253  0.412
2017 Matsuzawa-Ishimoto Y, Shono Y, Gomez LE, Hubbard-Lucey VM, Cammer M, Neil J, Dewan MZ, Lieberman SR, Lazrak A, Marinis JM, Beal A, Harris PA, Bertin J, Liu C, Ding Y, ... ... Cadwell K, et al. Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium. The Journal of Experimental Medicine. PMID 29089374 DOI: 10.1084/Jem.20170558  0.39
2017 Ruiz VE, Battaglia T, Kurtz ZD, Bijnens L, Ou A, Engstrand I, Zheng X, Iizumi T, Mullins BJ, Müller CL, Cadwell K, Bonneau R, Perez-Perez GI, Blaser MJ. A single early-in-life macrolide course has lasting effects on murine microbial network topology and immunity. Nature Communications. 8: 518. PMID 28894149 DOI: 10.1038/S41467-017-00531-6  0.346
2017 Alissafi T, Banos A, Boon L, Sparwasser T, Ghigo A, Wing K, Vassilopoulos D, Boumpas D, Chavakis T, Cadwell K, Verginis P. Tregs restrain dendritic cell autophagy to ameliorate autoimmunity. The Journal of Clinical Investigation. PMID 28581446 DOI: 10.1172/Jci92079  0.359
2017 Alissafi T, Banos A, Boon L, Sparwasser T, Vassilopoulos D, Boumpas D, Chavakis T, Cadwell K, Verginis P. 03.16 Regulatory t cells restrain autophagy in dendritic cells to ameliorate autoimmunity in a ctla4 dependent fashion Annals of the Rheumatic Diseases. 76. DOI: 10.1136/Annrheumdis-2016-211049.16  0.335
2017 Matsuzawa Y, Gomez LE, Cadwell K. Autophagy Protein ATG16L1 Confers Tolerance to a Commensal Virus by Preventing Cell Death in the Intestinal Epithelium Gastroenterology. 152. DOI: 10.1016/S0016-5085(17)30923-X  0.348
2016 Livanos AE, Greiner TU, Vangay P, Pathmasiri W, Stewart D, McRitchie S, Li H, Chung J, Sohn J, Kim S, Gao Z, Barber C, Kim J, Ng S, Rogers AB, ... ... Cadwell K, et al. Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Nature Microbiology. 1: 16140. PMID 27782139 DOI: 10.1038/Nmicrobiol.2016.140  0.326
2016 Cadwell K. Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis Nature Reviews Immunology. 16: 661-675. PMID 27694913 DOI: 10.1038/Nri.2016.100  0.367
2016 Ramanan D, Bowcutt R, Lee SC, Tang MS, Kurtz ZD, Ding Y, Honda K, Gause WC, Blaser MJ, Bonneau RA, Lim YA, Loke P, Cadwell K. Helminth infection promotes colonization resistance via type 2 immunity. Science (New York, N.Y.). PMID 27080105 DOI: 10.1126/Science.Aaf3229  0.427
2016 Ramanan D, Cadwell K. Intrinsic Defense Mechanisms of the Intestinal Epithelium. Cell Host & Microbe. PMID 27049583 DOI: 10.1016/J.Chom.2016.03.003  0.371
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Cadwell K, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356  0.32
2015 Sakowski ET, Koster S, Portal Celhay C, Park HS, Shrestha E, Hetzenecker SE, Maurer K, Cadwell K, Philips JA. Ubiquilin 1 Promotes IFN-γ-Induced Xenophagy of Mycobacterium tuberculosis. Plos Pathogens. 11: e1005076. PMID 26225865 DOI: 10.1371/Journal.Ppat.1005076  0.36
2015 Maurer K, Torres VJ, Cadwell K. Autophagy is a key tolerance mechanism during Staphylococcus aureus infection. Autophagy. 11: 1184-6. PMID 26046478 DOI: 10.1080/15548627.2015.1058685  0.387
2015 Cadwell K. The virome in host health and disease Immunity. 42: 805-813. PMID 25992857 DOI: 10.1016/J.Immuni.2015.05.003  0.378
2015 Maurer K, Reyes-Robles T, Alonzo F, Durbin J, Torres VJ, Cadwell K. Autophagy mediates tolerance to Staphylococcus aureus alpha-toxin. Cell Host & Microbe. 17: 429-40. PMID 25816775 DOI: 10.1016/J.Chom.2015.03.001  0.383
2015 Cadwell K. Expanding the Role of the Virome: Commensalism in the Gut Journal of Virology. 89: 1951-1953. PMID 25505079 DOI: 10.1128/Jvi.02966-14  0.378
2015 Kernbauer E, Maurer K, Torres VJ, Shopsin B, Cadwell K. Gastrointestinal dissemination and transmission of Staphylococcus aureus following bacteremia. Infection and Immunity. 83: 372-8. PMID 25385792 DOI: 10.1128/Iai.02272-14  0.349
2014 Kernbauer E, Ding Y, Cadwell K. An enteric virus can replace the beneficial function of commensal bacteria. Nature. 516: 94-8. PMID 25409145 DOI: 10.1038/Nature13960  0.433
2014 Hubbard-Lucey VM, Shono Y, Maurer K, West ML, Singer NV, Ziegler CG, Lezcano C, Motta AC, Schmid K, Levi SM, Murphy GF, Liu C, Winkler JD, Amaravadi RK, Rogler G, ... ... Cadwell K, et al. Autophagy gene Atg16L1 prevents lethal T cell alloreactivity mediated by dendritic cells. Immunity. 41: 579-91. PMID 25308334 DOI: 10.1016/J.Immuni.2014.09.011  0.398
2014 Kernbauer E, Cadwell K. Autophagy, viruses, and intestinal immunity. Current Opinion in Gastroenterology. 30: 539-546. PMID 25291356 DOI: 10.1097/Mog.0000000000000121  0.459
2014 Ramanan D, Tang MS, Bowcutt R, Loke P, Cadwell K. Bacterial sensor Nod2 prevents inflammation of the small intestine by restricting the expansion of the commensal Bacteroides vulgatus. Immunity. 41: 311-24. PMID 25088769 DOI: 10.1016/J.Immuni.2014.06.015  0.409
2014 Yu HB, Croxen MA, Marchiando AM, Ferreira RB, Cadwell K, Foster LJ, Finlay BB. Autophagy facilitates Salmonella replication in HeLa cells. Mbio. 5: e00865-14. PMID 24618251 DOI: 10.1128/Mbio.00865-14  0.383
2013 Patel KK, Miyoshi H, Beatty WL, Head RD, Malvin NP, Cadwell K, Guan JL, Saitoh T, Akira S, Seglen PO, Dinauer MC, Virgin HW, Stappenbeck TS. Autophagy proteins control goblet cell function by potentiating reactive oxygen species production. The Embo Journal. 32: 3130-44. PMID 24185898 DOI: 10.1038/Emboj.2013.233  0.347
2013 Cadwell K, Philips JA. Autophagy meets phagocytosis. Immunity. 39: 425-7. PMID 24054324 DOI: 10.1016/J.Immuni.2013.08.027  0.343
2013 Marchiando AM, Ramanan D, Ding Y, Gomez LE, Hubbard-Lucey VM, Maurer K, Wang C, Ziel JW, van Rooijen N, Nuñez G, Finlay BB, Mysorekar IU, Cadwell K. A deficiency in the autophagy gene Atg16L1 enhances resistance to enteric bacterial infection. Cell Host & Microbe. 14: 216-24. PMID 23954160 DOI: 10.1016/J.Chom.2013.07.013  0.446
2013 Cadwell K. Bacteria, it’s What’s for Dinner Cell Host & Microbe. 13: 627-628. PMID 23768486 DOI: 10.1016/J.Chom.2013.05.011  0.367
2012 Wang C, Mendonsa GR, Symington JW, Zhang Q, Cadwell K, Virgin HW, Mysorekar IU. Atg16L1 deficiency confers protection from uropathogenic Escherichia coli infection in vivo. Proceedings of the National Academy of Sciences of the United States of America. 109: 11008-13. PMID 22715292 DOI: 10.1073/Pnas.1203952109  0.438
2011 Hubbard VM, Cadwell K. Viruses, autophagy genes, and Crohn's disease. Viruses. 3: 1281-311. PMID 21994779 DOI: 10.3390/V3071281  0.386
2010 Cadwell K, Patel KK, Maloney NS, Liu TC, Ng AC, Storer CE, Head RD, Xavier R, Stappenbeck TS, Virgin HW. Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine. Cell. 141: 1135-45. PMID 20602997 DOI: 10.1016/J.Cell.2010.05.009  0.348
2009 Cadwell K, Stappenbeck TS, Virgin HW. Role of autophagy and autophagy genes in inflammatory bowel disease. Current Topics in Microbiology and Immunology. 335: 141-67. PMID 19802564 DOI: 10.1007/978-3-642-00302-8_7  0.44
2009 Ju JS, Miller SE, Jackson E, Cadwell K, Piwnica-Worms D, Weihl CC. Quantitation of selective autophagic protein aggregate degradation in vitro and in vivo using luciferase reporters. Autophagy. 5: 511-9. PMID 19305149 DOI: 10.4161/Auto.5.4.7761  0.309
2009 Cadwell K, Patel KK, Komatsu M, Virgin HW, Stappenbeck TS. A common role for Atg16L1, Atg5 and Atg7 in small intestinal Paneth cells and Crohn disease. Autophagy. 5: 250-2. PMID 19139628 DOI: 10.4161/Auto.5.2.7560  0.388
2008 Zhao Z, Fux B, Goodwin M, Dunay IR, Strong D, Miller BC, Cadwell K, Delgado MA, Ponpuak M, Green KG, Schmidt RE, Mizushima N, Deretic V, Sibley LD, Virgin HW. Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens. Cell Host & Microbe. 4: 458-69. PMID 18996346 DOI: 10.1016/J.Chom.2008.10.003  0.402
2008 Cadwell K, Liu JY, Brown SL, Miyoshi H, Loh J, Lennerz JK, Kishi C, Kc W, Carrero JA, Hunt S, Stone CD, Brunt EM, Xavier RJ, Sleckman BP, Li E, et al. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature. 456: 259-63. PMID 18849966 DOI: 10.1038/Nature07416  0.417
2008 Cadwell K, Coscoy L. The specificities of Kaposi's sarcoma-associated herpesvirus-encoded E3 ubiquitin ligases are determined by the positions of lysine or cysteine residues within the intracytoplasmic domains of their targets. Journal of Virology. 82: 4184-9. PMID 18272573 DOI: 10.1128/Jvi.02264-07  0.621
2005 Cadwell K, Coscoy L. Ubiquitination on nonlysine residues by a viral E3 ubiquitin ligase. Science (New York, N.Y.). 309: 127-30. PMID 15994556 DOI: 10.1126/Science.1110340  0.62
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