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Aliaksandr Druz, Ph.D. - Publications

Affiliations: 
2013 Chemical and Biomolecular Engineering Johns Hopkins University, Baltimore, MD 
Area:
Chemical Engineering, Biochemistry, Cell Biology, Oncology
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47 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Gorman J, Chuang GY, Lai YT, Shen CH, Boyington JC, Druz A, Geng H, Louder MK, McKee K, Rawi R, Verardi R, Yang Y, Zhang B, Doria-Rose NA, Lin B, et al. Structure of Super-Potent Antibody CAP256-VRC26.25 in Complex with HIV-1 Envelope Reveals a Combined Mode of Trimer-Apex Recognition. Cell Reports. 31: 107488. PMID 32268107 DOI: 10.1016/J.Celrep.2020.03.052  0.388
2020 Ou L, Kong WP, Chuang GY, Ghosh M, Gulla K, O'Dell S, Varriale J, Barefoot N, Changela A, Chao CW, Cheng C, Druz A, Kong R, McKee K, Rawi R, et al. Preclinical Development of a Fusion Peptide Conjugate as an HIV Vaccine Immunogen. Scientific Reports. 10: 3032. PMID 32080235 DOI: 10.1038/S41598-020-59711-Y  0.371
2019 Krebs SJ, Kwon YD, Schramm CA, Law WH, Donofrio G, Zhou KH, Gift S, Dussupt V, Georgiev IS, Schätzle S, McDaniel JR, Lai YT, Sastry M, Zhang B, Jarosinski MC, ... ... Druz A, et al. Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual. Immunity. PMID 30876875 DOI: 10.1016/J.Immuni.2019.02.008  0.432
2019 Lai YT, Wang T, O’Dell S, Louder MK, Schön A, Cheung CSF, Chuang GY, Druz A, Lin B, McKee K, Peng D, Yang Y, Zhang B, Herschhorn A, Sodroski J, et al. Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry. Nature Communications. 10: 47-47. DOI: 10.2210/Pdb6Mu6/Pdb  0.35
2018 Stewart-Jones GBE, Chuang GY, Xu K, Zhou T, Acharya P, Tsybovsky Y, Ou L, Zhang B, Fernandez-Rodriguez B, Gilardi V, Silacci-Fregni C, Beltramello M, Baxa U, Druz A, Kong WP, et al. Structure-based design of a quadrivalent fusion glycoprotein vaccine for human parainfluenza virus types 1-4. Proceedings of the National Academy of Sciences of the United States of America. PMID 30420505 DOI: 10.1073/Pnas.1811980115  0.335
2018 Xu K, Acharya P, Kong R, Cheng C, Chuang GY, Liu K, Louder MK, O'Dell S, Rawi R, Sastry M, Shen CH, Zhang B, Zhou T, Asokan M, Bailer RT, ... ... Druz A, et al. Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1. Nature Medicine. PMID 29867235 DOI: 10.1038/s41591-018-0042-6  0.303
2018 Georgiev IS, Joyce MG, Chen RE, Leung K, McKee K, Druz A, Van Galen JG, Kanekiyo M, Tsybovsky Y, Yang ES, Yang Y, Acharya P, Pancera M, Thomas PV, Wanninger T, et al. Two-Component Ferritin Nanoparticles for Multimerization of Diverse Trimeric Antigens. Acs Infectious Diseases. PMID 29451984 DOI: 10.1021/Acsinfecdis.7B00192  0.332
2018 Xu K, Acharya P, Kong R, Cheng C, Chuang GY, Liu K, Louder MK, O'Dell S, Rawi R, Sastry M, Shen CH, Zhang B, Zhou T, Asokan M, Bailer RT, ... ... Druz A, et al. Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1. Nature Medicine. 24: 857-867. DOI: 10.2210/Pdb6Cdp/Pdb  0.415
2017 Joyce MG, Georgiev IS, Yang Y, Druz A, Geng H, Chuang GY, Kwon YD, Pancera M, Rawi R, Sastry M, Stewart-Jones GBE, Zheng A, Zhou T, Choe M, Van Galen JG, et al. Soluble Prefusion Closed DS-SOSIP.664-Env Trimers of Diverse HIV-1 Strains. Cell Reports. 21: 2992-3002. PMID 29212041 DOI: 10.1016/J.Celrep.2017.11.016  0.356
2017 Pancera M, Lai YT, Bylund T, Druz A, Narpala S, O'Dell S, Schön A, Bailer RT, Chuang GY, Geng H, Louder MK, Rawi R, Soumana DI, Finzi A, Herschhorn A, et al. Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529. Nature Chemical Biology. PMID 28825711 DOI: 10.1038/Nchembio.2460  0.362
2017 Cale EM, Gorman J, Radakovich NA, Crooks ET, Osawa K, Tong T, Li J, Nagarajan R, Ozorowski G, Ambrozak DR, Asokan M, Bailer RT, Bennici AK, Chen X, Doria-Rose NA, ... Druz A, et al. Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop. Immunity. 46: 777-791.e10. PMID 28514685 DOI: 10.1016/J.Immuni.2017.04.011  0.433
2017 Zhou T, Doria-Rose NA, Cheng C, Stewart-Jones GBE, Chuang GY, Chambers M, Druz A, Geng H, McKee K, Kwon YD, O'Dell S, Sastry M, Schmidt SD, Xu K, Chen L, et al. Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation. Cell Reports. 19: 719-732. PMID 28445724 DOI: 10.1016/J.Celrep.2017.04.013  0.403
2017 Alam SM, Aussedat B, Vohra Y, Ryan Meyerhoff R, Cale EM, Walkowicz WE, Radakovich NA, Anasti K, Armand L, Parks R, Sutherland L, Scearce R, Joyce MG, Pancera M, Druz A, et al. Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide. Science Translational Medicine. 9. PMID 28298421 DOI: 10.1126/Scitranslmed.Aai7521  0.381
2017 Chuang GY, Geng H, Pancera M, Xu K, Cheng C, Acharya P, Chambers M, Druz A, Tsybovsky Y, Wanninger TG, Yang Y, Doria-Rose NA, Georgiev IS, Gorman J, Joyce MG, et al. Structure-Based Design of a Soluble Prefusion-Closed HIV-1-Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity. Journal of Virology. PMID 28275193 DOI: 10.1128/Jvi.02268-16  0.422
2017 Liu Q, Acharya P, Dolan MA, Zhang P, Guzzo C, Lu J, Kwon A, Gururani D, Miao H, Bylund T, Chuang GY, Druz A, Zhou T, Rice WJ, Wigge C, et al. Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer. Nature Structural & Molecular Biology. PMID 28218750 DOI: 10.1038/Nsmb.3382  0.316
2017 Wibmer CK, Gorman J, Ozorowski G, Bhiman JN, Sheward DJ, Elliott DH, Rouelle J, Smira A, Joyce MG, Ndabambi N, Druz A, Asokan M, Burton DR, Connors M, Abdool Karim SS, et al. Structure and Recognition of a Novel HIV-1 gp120-gp41 Interface Antibody that Caused MPER Exposure through Viral Escape. Plos Pathogens. 13: e1006074. PMID 28076415 DOI: 10.1371/Journal.Ppat.1006074  0.412
2017 Pancera M, Soumana D, Narpala S, Schon A, Oʼdell S, Druz A, Chuang G, Louder M, Langley D, Freire E, Sodroski J, Mascola J, Mcdermott A, Kwong P. P-D3 Crystal structures of small-molecules HIV-1 entry ihibitor, BMS-378806 and BMS-626529, bound to BG505 SOSIP.664 HIV-1 Env trimer reveal an allosteric competitive etry inhibition mechanism Jaids Journal of Acquired Immune Deficiency Syndromes. 74: 90. DOI: 10.1097/01.Qai.0000513993.43764.Ae  0.337
2017 Acharya P, Liu Q, Ma X, Lu M, Dandey V, Eng ET, Rice WJ, Wigge C, Bylund T, Chuang G, Druz A, Geng H, Gorman J, Zhou T, Mothes W, et al. Conformational Changes in HIV-1 Env Trimer Induced by a Single CD4 as Revealed by Cryo-EM Microscopy and Microanalysis. 23: 1190-1191. DOI: 10.1017/S1431927617006614  0.339
2016 Huang J, Kang BH, Ishida E, Zhou T, Griesman T, Sheng Z, Wu F, Doria-Rose NA, Zhang B, McKee K, O'Dell S, Chuang GY, Druz A, Georgiev IS, Schramm CA, et al. Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth. Immunity. 45: 1108-1121. PMID 27851912 DOI: 10.1016/J.Immuni.2016.10.027  0.4
2016 Lee J, Boutz DR, Chromikova V, Joyce MG, Vollmers C, Leung K, Horton AP, DeKosky BJ, Lee CH, Lavinder JJ, Murrin EM, Chrysostomou C, Hoi KH, Tsybovsky Y, Thomas PV, ... Druz A, et al. Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination. Nature Medicine. PMID 27820605 DOI: 10.1038/Nm.4224  0.351
2016 Wibmer CK, Gorman J, Anthony CS, Mkhize NN, Druz A, York T, Schmidt SD, Labuschagne P, Louder MK, Bailer RT, Abdool Karim SS, Mascola JR, Williamson C, Moore PL, Kwong PD, et al. Structure of an N276-dependent HIV-1 Neutralizing Antibody Targeting a Rare V5 Glycan Hole adjacent to the CD4 Binding Site. Journal of Virology. PMID 27581986 DOI: 10.1128/Jvi.01357-16  0.408
2016 Kabanova A, Marcandalli J, Zhou T, Bianchi S, Baxa U, Tsybovsky Y, Lilleri D, Silacci-Fregni C, Foglierini M, Fernandez-Rodriguez BM, Druz A, Zhang B, Geiger R, Pagani M, Sallusto F, et al. Platelet-derived growth factor-α receptor is the cellular receptor for human cytomegalovirus gHgLgO trimer. Nature Microbiology. 1: 16082. PMID 27573107 DOI: 10.1038/Nmicrobiol.2016.82  0.313
2016 Joyce MG, Zhang B, Ou L, Chen M, Chuang GY, Druz A, Kong WP, Lai YT, Rundlet EJ, Tsybovsky Y, Yang Y, Georgiev IS, Guttman M, Lees CR, Pancera M, et al. Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV. Nature Structural & Molecular Biology. PMID 27478931 DOI: 10.1038/Nsmb.3267  0.308
2016 Boyington JC, Joyce MG, Sastry M, Stewart-Jones GB, Chen M, Kong WP, Ngwuta JO, Thomas PV, Tsybovsky Y, Yang Y, Zhang B, Chen L, Druz A, Georgiev IS, Ko K, et al. Structure-Based Design of Head-Only Fusion Glycoprotein Immunogens for Respiratory Syncytial Virus. Plos One. 11: e0159709. PMID 27463224 DOI: 10.1371/Journal.Pone.0159709  0.309
2016 Joyce MG, Wheatley AK, Thomas PV, Chuang GY, Soto C, Bailer RT, Druz A, Georgiev IS, Gillespie RA, Kanekiyo M, Kong WP, Leung K, Narpala SN, Prabhakaran MS, Yang ES, et al. Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses. Cell. PMID 27453470 DOI: 10.1016/J.Cell.2016.06.043  0.336
2016 Kong R, Xu K, Zhou T, Acharya P, Lemmin T, Liu K, Ozorowski G, Soto C, Taft JD, Bailer RT, Cale EM, Chen L, Choi CW, Chuang GY, Doria-Rose NA, ... Druz A, et al. Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody. Science (New York, N.Y.). 352: 828-33. PMID 27174988 DOI: 10.1126/Science.Aae0474  0.341
2016 Stewart-Jones GB, Soto C, Lemmin T, Chuang GY, Druz A, Kong R, Thomas PV, Wagh K, Zhou T, Behrens AJ, Bylund T, Choi CW, Davison JR, Georgiev IS, Joyce MG, et al. Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G. Cell. PMID 27114034 DOI: 10.1016/J.Cell.2016.04.010  0.408
2016 Kwon YD, Georgiev IS, Ofek G, Zhang B, Asokan M, Bailer RT, Bao A, Caruso W, Chen X, Choe M, Druz A, Ko SY, Louder MK, McKee K, O'Dell S, et al. Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design. Journal of Virology. PMID 27053554 DOI: 10.1128/Jvi.03246-15  0.36
2016 Bonsignori M, Zhou T, Sheng Z, Chen L, Gao F, Joyce MG, Ozorowski G, Chuang GY, Schramm CA, Wiehe K, Alam SM, Bradley T, Gladden MA, Hwang KK, Iyengar S, ... ... Druz A, et al. Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody. Cell. PMID 26949186 DOI: 10.1016/J.Cell.2016.02.022  0.373
2015 Cheng C, Pancera M, Bossert A, Schmidt SD, Chen R, Chen X, Druz A, Narpala S, Doria-Rose NA, McDermott AB, Kwong PD, Mascola JR. Immunogenicity of a Prefusion HIV-1-Envelope Trimer in Complex with a Quaternary-Specific Antibody. Journal of Virology. PMID 26719262 DOI: 10.1128/Jvi.02380-15  0.42
2015 Gorman J, Soto C, Yang MM, Davenport TM, Guttman M, Bailer RT, Chambers M, Chuang GY, DeKosky BJ, Doria-Rose NA, Druz A, Ernandes MJ, Georgiev IS, Jarosinski MC, Joyce MG, et al. Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design. Nature Structural & Molecular Biology. PMID 26689967 DOI: 10.1038/Nsmb.3144  0.407
2015 Doria-Rose NA, Bhiman JN, Roark RS, Schramm CA, Gorman J, Chuang GY, Pancera M, Cale EM, Ernandes MJ, Louder MK, Asokan M, Bailer RT, Druz A, Fraschilla IR, Garrett NJ, et al. A new member of the V1V2-directed CAP256-VRC26 lineage that shows increased breadth and exceptional potency. Journal of Virology. PMID 26468542 DOI: 10.1128/Jvi.01791-15  0.411
2015 Ngwuta JO, Chen M, Modjarrad K, Joyce MG, Kanekiyo M, Kumar A, Yassine HM, Moin SM, Killikelly AM, Chuang GY, Druz A, Georgiev IS, Rundlet EJ, Sastry M, Stewart-Jones GB, et al. Prefusion F-specific antibodies determine the magnitude of RSV neutralizing activity in human sera. Science Translational Medicine. 7: 309ra162. PMID 26468324 DOI: 10.1126/Scitranslmed.Aac4241  0.327
2015 Do Kwon Y, Pancera M, Acharya P, Georgiev IS, Crooks ET, Gorman J, Joyce MG, Guttman M, Ma X, Narpala S, Soto C, Terry DS, Yang Y, Zhou T, Ahlsen G, ... ... Druz A, et al. Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env. Nature Structural & Molecular Biology. 22: 522-31. PMID 26098315 DOI: 10.1038/Nsmb.3051  0.412
2015 Zhou T, Lynch RM, Chen L, Acharya P, Wu X, Doria-Rose NA, Joyce MG, Lingwood D, Soto C, Bailer RT, Ernandes MJ, Kong R, Longo NS, Louder MK, McKee K, ... ... Druz A, et al. Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors. Cell. 161: 1280-92. PMID 26004070 DOI: 10.1016/J.Cell.2015.05.007  0.419
2015 Georgiev IS, Joyce MG, Yang Y, Sastry M, Zhang B, Baxa U, Chen RE, Druz A, Lees CR, Narpala S, Schön A, Van Galen J, Chuang GY, Gorman J, Harned A, et al. Single-Chain Soluble BG505.SOSIP gp140 Trimers as Structural and Antigenic Mimics of Mature Closed HIV-1 Env. Journal of Virology. 89: 5318-29. PMID 25740988 DOI: 10.1128/Jvi.03451-14  0.343
2014 Pancera M, Zhou T, Druz A, Georgiev IS, Soto C, Gorman J, Huang J, Acharya P, Chuang GY, Ofek G, Stewart-Jones GB, Stuckey J, Bailer RT, Joyce MG, Louder MK, et al. Structure and immune recognition of trimeric pre-fusion HIV-1 Env. Nature. 514: 455-61. PMID 25296255 DOI: 10.1038/Nature13808  0.401
2014 Huang J, Kang BH, Pancera M, Lee JH, Tong T, Feng Y, Imamichi H, Georgiev IS, Chuang GY, Druz A, Doria-Rose NA, Laub L, Sliepen K, van Gils MJ, de la Peña AT, et al. Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface. Nature. 515: 138-42. PMID 25186731 DOI: 10.1038/Nature13601  0.403
2014 Rudicell RS, Kwon YD, Ko SY, Pegu A, Louder MK, Georgiev IS, Wu X, Zhu J, Boyington JC, Chen X, Shi W, Yang ZY, Doria-Rose NA, McKee K, O'Dell S, ... ... Druz A, et al. Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo. Journal of Virology. 88: 12669-82. PMID 25142607 DOI: 10.1128/Jvi.02213-14  0.415
2014 Zhou T, Zhu J, Yang Y, Gorman J, Ofek G, Srivatsan S, Druz A, Lees CR, Lu G, Soto C, Stuckey J, Burton DR, Koff WC, Connors M, Kwong PD, et al. Transplanting supersites of HIV-1 vulnerability. Plos One. 9: e99881. PMID 24992528 DOI: 10.1371/Journal.Pone.0099881  0.408
2014 Doria-Rose NA, Schramm CA, Gorman J, Moore PL, Bhiman JN, DeKosky BJ, Ernandes MJ, Georgiev IS, Kim HJ, Pancera M, Staupe RP, Altae-Tran HR, Bailer RT, Crooks ET, Cupo A, ... Druz A, et al. Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies. Nature. 509: 55-62. PMID 24590074 DOI: 10.1038/Nature13036  0.456
2013 Jadhav V, Hackl M, Druz A, Shridhar S, Chung CY, Heffner KM, Kreil DP, Betenbaugh M, Shiloach J, Barron N, Grillari J, Borth N. CHO microRNA engineering is growing up: recent successes and future challenges. Biotechnology Advances. 31: 1501-13. PMID 23916872 DOI: 10.1016/J.Biotechadv.2013.07.007  0.511
2013 Druz A, Son YJ, Betenbaugh M, Shiloach J. Stable inhibition of mmu-miR-466h-5p improves apoptosis resistance and protein production in CHO cells. Metabolic Engineering. 16: 87-94. PMID 23376592 DOI: 10.1016/J.Ymben.2012.12.004  0.623
2013 Druz A, Chen YC, Guha R, Betenbaugh M, Martin SE, Shiloach J. Large-scale screening identifies a novel microRNA, miR-15a-3p, which induces apoptosis in human cancer cell lines. Rna Biology. 10: 287-300. PMID 23353574 DOI: 10.4161/Rna.23339  0.584
2012 Druz A, Betenbaugh M, Shiloach J. Glucose depletion activates mmu-miR-466h-5p expression through oxidative stress and inhibition of histone deacetylation. Nucleic Acids Research. 40: 7291-302. PMID 22638581 DOI: 10.1093/Nar/Gks452  0.596
2012 Shiloach J, Druz A, Betenbaugh M. MicroRNAs as engineering targets: Pathway manipulation to impact bioprocess phenotypes Micrornas as Tools in Biopharmaceutical Production. 2147483647: 65-85. DOI: 10.1007/978-94-007-5128-6_5  0.479
2011 Druz A, Chu C, Majors B, Santuary R, Betenbaugh M, Shiloach J. A novel microRNA mmu-miR-466h affects apoptosis regulation in mammalian cells. Biotechnology and Bioengineering. 108: 1651-61. PMID 21337326 DOI: 10.1002/Bit.23092  0.596
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