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Jan Karlseder - Publications

Affiliations: 
Molecular and Cell Biology Salk Institute for Biological Studies, La Jolla, CA, United States 
Website:
http://www.salk.edu/faculty/faculty_details.php?id=30
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65 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Moreno SP, Fusté JM, Kaiser M, Li JSZ, Nassour J, Haggblom C, Denchi EL, Karlseder J. TZAP overexpression induces telomere dysfunction and ALT-like activity in ATRX/DAXX-deficient cells. Iscience. 26: 106405. PMID 37013192 DOI: 10.1016/j.isci.2023.106405  0.495
2023 Jones CY, Williams CL, Moreno SP, Morris DK, Mondello C, Karlseder J, Bertuch AA. Hyperextended telomeres promote formation of C-circle DNA in telomerase positive human cells. The Journal of Biological Chemistry. 104665. PMID 37003504 DOI: 10.1016/j.jbc.2023.104665  0.413
2023 Nassour J, Aguiar LG, Correia A, Schmidt TT, Mainz L, Przetocka S, Haggblom C, Tadepalle N, Williams A, Shokhirev MN, Akincilar SC, Tergaonkar V, Shadel GS, Karlseder J. Telomere-to-mitochondria signalling by ZBP1 mediates replicative crisis. Nature. PMID 36755096 DOI: 10.1038/s41586-023-05710-8  0.428
2023 Jones CY, Williams CL, Moreno SP, Morris DK, Mondello C, Karlseder J, Bertuch AA. Hyperextended telomeres promote C-circle formation in telomerase positive human cells. Biorxiv : the Preprint Server For Biology. PMID 36747763 DOI: 10.1101/2023.01.26.525615  0.374
2021 Nassour J, Schmidt TT, Karlseder J. Telomeres and Cancer: Resolving the Paradox. Annual Review of Cancer Biology. 5: 59-77. PMID 34532611 DOI: 10.1146/annurev-cancerbio-050420-023410  0.426
2019 Masamsetti VP, Low RRJ, Mak KS, O'Connor A, Riffkin CD, Lamm N, Crabbe L, Karlseder J, Huang DCS, Hayashi MT, Cesare AJ. Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection. Nature Communications. 10: 4224. PMID 31530811 DOI: 10.1038/S41467-019-12255-W  0.434
2019 Nassour J, Radford R, Correia A, Fusté JM, Schoell B, Jauch A, Shaw RJ, Karlseder J. Autophagic cell death restricts chromosomal instability during replicative crisis. Nature. PMID 30675059 DOI: 10.1038/S41586-019-0885-0  0.535
2019 Karlseder J, Belayew A, Laurent B. Decision letter: Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment Elife. DOI: 10.7554/Elife.47333.Sa1  0.313
2018 Spinler K, Reya T, Bajaj J, Ito T, Zimdahl B, Ahmadi A, Koechlein C, Lytle N, Kwon HY, Anower-E-Khuda F, Kritzik M, Karlseder J, Park PW, Esko J. Identification of Syndecan-1 As a Key Dependency of Myeloid Leukemia Growth and Dissemination Blood. 132: 3003-3003. DOI: 10.1182/Blood-2018-99-115199  0.325
2017 Arnoult N, Correia A, Ma J, Merlo A, Garcia-Gomez S, Maric M, Tognetti M, Benner CW, Boulton SJ, Saghatelian A, Karlseder J. Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN. Nature. 549: 548-552. PMID 28959974 DOI: 10.1038/Nature24023  0.491
2017 Li JS, Miralles Fuste J, Simavorian T, Bartocci C, Tsai J, Karlseder J, Lazzerini Denchi E. TZAP: A telomere-associated protein involved in telomere length control. Science (New York, N.Y.). PMID 28082411 DOI: 10.1126/Science.Aah6752  0.763
2016 Rivera T, Haggblom C, Cosconati S, Karlseder J. A balance between elongation and trimming regulates telomere stability in stem cells. Nature Structural & Molecular Biology. PMID 27918544 DOI: 10.1038/Nsmb.3335  0.608
2015 Arnoult N, Karlseder J. Complex interactions between the DNA-damage response and mammalian telomeres. Nature Structural & Molecular Biology. 22: 859-66. PMID 26581520 DOI: 10.1038/Nsmb.3092  0.643
2015 Hayashi MT, Cesare AJ, Rivera T, Karlseder J. Cell death during crisis is mediated by mitotic telomere deprotection. Nature. 522: 492-6. PMID 26108857 DOI: 10.1038/Nature14513  0.515
2014 Arnoult N, Karlseder J. ALT telomeres borrow from meiosis to get moving. Cell. 159: 11-2. PMID 25259914 DOI: 10.1016/J.Cell.2014.09.013  0.567
2014 Karlseder J. Modern genome editing meets telomeres: the many functions of TPP1. Genes & Development. 28: 1857-8. PMID 25184673 DOI: 10.1101/Gad.250316.114  0.51
2014 Lackner DH, Hayashi MT, Cesare AJ, Karlseder J. A genomics approach identifies senescence-specific gene expression regulation. Aging Cell. 13: 946-50. PMID 24863242 DOI: 10.1111/Acel.12234  0.425
2014 O'Sullivan RJ, Arnoult N, Lackner DH, Oganesian L, Haggblom C, Corpet A, Almouzni G, Karlseder J. Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1. Nature Structural & Molecular Biology. 21: 167-74. PMID 24413054 DOI: 10.1038/Nsmb.2754  0.562
2014 Hayashi MT, Karlseder J. Abstract IA20: A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest Cancer Research. 74. DOI: 10.1158/1538-7445.Cansusc14-Ia20  0.639
2013 Lackner DH, Karlseder J. C. elegans survivors without telomerase. Worm. 2: e21073. PMID 24058854 DOI: 10.4161/worm.21073  0.464
2013 Cesare AJ, Hayashi MT, Crabbe L, Karlseder J. The telomere deprotection response is functionally distinct from the genomic DNA damage response. Molecular Cell. 51: 141-55. PMID 23850488 DOI: 10.1016/J.Molcel.2013.06.006  0.602
2013 Oganesian L, Karlseder J. 5' C-rich telomeric overhangs are an outcome of rapid telomere truncation events. Dna Repair. 12: 238-45. PMID 23347616 DOI: 10.1016/J.Dnarep.2012.12.008  0.615
2013 Hayashi MT, Karlseder J. DNA damage associated with mitosis and cytokinesis failure. Oncogene. 32: 4593-601. PMID 23318447 DOI: 10.1038/Onc.2012.615  0.541
2012 Crabbe L, Cesare AJ, Kasuboski JM, Fitzpatrick JA, Karlseder J. Human telomeres are tethered to the nuclear envelope during postmitotic nuclear assembly. Cell Reports. 2: 1521-9. PMID 23260663 DOI: 10.1016/J.Celrep.2012.11.019  0.506
2012 O'Sullivan RJ, Karlseder J. The great unravelling: chromatin as a modulator of the aging process. Trends in Biochemical Sciences. 37: 466-76. PMID 22959736 DOI: 10.1016/J.Tibs.2012.08.001  0.341
2012 Cesare AJ, Karlseder J. A three-state model of telomere control over human proliferative boundaries. Current Opinion in Cell Biology. 24: 731-8. PMID 22947495 DOI: 10.1016/J.Ceb.2012.08.007  0.467
2012 Barefield C, Karlseder J. The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structures. Nucleic Acids Research. 40: 7358-67. PMID 22576367 DOI: 10.1093/Nar/Gks407  0.64
2012 Lackner DH, Raices M, Maruyama H, Haggblom C, Karlseder J. Organismal propagation in the absence of a functional telomerase pathway in Caenorhabditis elegans. The Embo Journal. 31: 2024-33. PMID 22425786 DOI: 10.1038/Emboj.2012.61  0.515
2012 Hayashi MT, Cesare AJ, Fitzpatrick JA, Lazzerini-Denchi E, Karlseder J. A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest. Nature Structural & Molecular Biology. 19: 387-94. PMID 22407014 DOI: 10.1038/Nsmb.2245  0.641
2012 Hayashi M, Cesare A, Fitzpatrick J, Denchi EL, Karlseder J. Abstract SY23-02: A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest Molecular and Cellular Biology. DOI: 10.1158/1538-7445.Am2012-Sy23-02  0.572
2011 Lackner DH, Durocher D, Karlseder J. A siRNA-based screen for genes involved in chromosome end protection. Plos One. 6: e21407. PMID 21760879 DOI: 10.1371/Journal.Pone.0021407  0.634
2011 Oganesian L, Karlseder J. Mammalian 5' C-rich telomeric overhangs are a mark of recombination-dependent telomere maintenance. Molecular Cell. 42: 224-36. PMID 21504833 DOI: 10.1016/J.Molcel.2011.03.015  0.532
2011 Flynn RL, Centore RC, O'Sullivan RJ, Rai R, Tse A, Songyang Z, Chang S, Karlseder J, Zou L. TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA. Nature. 471: 532-6. PMID 21399625 DOI: 10.1038/Nature09772  0.625
2011 Corpet A, De Koning L, Toedling J, Savignoni A, Berger F, Lemaître C, O'Sullivan RJ, Karlseder J, Barillot E, Asselain B, Sastre-Garau X, Almouzni G. Asf1b, the necessary Asf1 isoform for proliferation, is predictive of outcome in breast cancer. The Embo Journal. 30: 480-93. PMID 21179005 DOI: 10.1038/Emboj.2010.335  0.305
2011 Orazio NI, Naeger CM, Karlseder J, Weitzman MD. The adenovirus E1b55K/E4orf6 complex induces degradation of the Bloom helicase during infection. Journal of Virology. 85: 1887-92. PMID 21123383 DOI: 10.1128/Jvi.02134-10  0.326
2010 O'Sullivan RJ, Kubicek S, Schreiber SL, Karlseder J. Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres. Nature Structural & Molecular Biology. 17: 1218-25. PMID 20890289 DOI: 10.1038/Nsmb.1897  0.405
2010 Crabbe L, Karlseder J. Mammalian Rap1 widens its impact. Nature Cell Biology. 12: 733-5. PMID 20622867 DOI: 10.1038/Ncb2088  0.546
2010 O'Sullivan RJ, Karlseder J. Telomeres: protecting chromosomes against genome instability. Nature Reviews. Molecular Cell Biology. 11: 171-81. PMID 20125188 DOI: 10.1038/Nrm2848  0.634
2009 Begemann S, Galimi F, Karlseder J. Moderate expression of TRF2 in the hematopoietic system increases development of large cell blastic T-cell lymphomas. Aging. 1: 122-130. PMID 20046894  0.376
2009 Karlseder J. Chromosome end protection becomes even more complex. Nature Structural & Molecular Biology. 16: 1205-6. PMID 19956204 DOI: 10.1038/Nsmb1209-1205  0.578
2009 Oganesian L, Karlseder J. Telomeric armor: the layers of end protection. Journal of Cell Science. 122: 4013-25. PMID 19910493 DOI: 10.1242/Jcs.050567  0.607
2009 Sfeir A, Kosiyatrakul ST, Hockemeyer D, MacRae SL, Karlseder J, Schildkraut CL, de Lange T. Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell. 138: 90-103. PMID 19596237 DOI: 10.1016/J.Cell.2009.06.021  0.778
2008 Raices M, Verdun RE, Compton SA, Haggblom CI, Griffith JD, Dillin A, Karlseder J. C. elegans telomeres contain G-strand and C-strand overhangs that are bound by distinct proteins. Cell. 132: 745-57. PMID 18329362 DOI: 10.1016/J.Cell.2007.12.039  0.541
2007 Verdun RE, Karlseder J. Replication and protection of telomeres. Nature. 447: 924-31. PMID 17581575 DOI: 10.1038/Nature05976  0.631
2007 Karlseder J, Cooper JP. Of wombats and whales: telomere tales in Madrid. Conference on telomeres and telomerase. Embo Reports. 8: 542-6. PMID 17510654 DOI: 10.1038/Sj.Embor.7400985  0.53
2007 Crabbe L, Jauch A, Naeger CM, Holtgreve-Grez H, Karlseder J. Telomere dysfunction as a cause of genomic instability in Werner syndrome. Proceedings of the National Academy of Sciences of the United States of America. 104: 2205-10. PMID 17284601 DOI: 10.1073/Pnas.0609410104  0.567
2006 Verdun RE, Karlseder J. The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres. Cell. 127: 709-20. PMID 17110331 DOI: 10.1016/J.Cell.2006.09.034  0.658
2006 Karlseder J. Telomeric proteins: clearing the way for the replication fork. Nature Structural & Molecular Biology. 13: 386-7. PMID 16738605 DOI: 10.1038/Nsmb0506-386  0.503
2005 Verdun RE, Crabbe L, Haggblom C, Karlseder J. Functional human telomeres are recognized as DNA damage in G2 of the cell cycle. Molecular Cell. 20: 551-61. PMID 16307919 DOI: 10.1016/J.Molcel.2005.09.024  0.659
2005 Raices M, Maruyama H, Dillin A, Karlseder J. Uncoupling of longevity and telomere length in C. elegans. Plos Genetics. 1: e30. PMID 16151516 DOI: 10.1371/Journal.Pgen.0010030  0.49
2005 Crabbe L, Karlseder J. In the end, it's all structure. Current Molecular Medicine. 5: 135-43. PMID 15974866 DOI: 10.2174/1566524053586527  0.649
2005 Raices M, Maruyama H, Dillin A, Karlseder J. Correction: Uncoupling of Longevity and Telomere Length in C. elegans Plos Genetics. 1: e81. DOI: 10.1371/Journal.Pgen.0010081  0.376
2004 Crabbe L, Verdun RE, Haggblom CI, Karlseder J. Defective telomere lagging strand synthesis in cells lacking WRN helicase activity. Science (New York, N.Y.). 306: 1951-3. PMID 15591207 DOI: 10.1126/Science.1103619  0.596
2004 Karlseder J, Hoke K, Mirzoeva OK, Bakkenist C, Kastan MB, Petrini JH, de Lange T. The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. Plos Biology. 2: E240. PMID 15314656 DOI: 10.1371/Journal.Pbio.0020240  0.721
2003 Karlseder J, Kachatrian L, Takai H, Mercer K, Hingorani S, Jacks T, de Lange T. Targeted deletion reveals an essential function for the telomere length regulator Trf1. Molecular and Cellular Biology. 23: 6533-41. PMID 12944479 DOI: 10.1128/Mcb.23.18.6533-6541.2003  0.741
2003 Karlseder J. Telomere repeat binding factors: keeping the ends in check. Cancer Letters. 194: 189-97. PMID 12757977 DOI: 10.1016/S0304-3835(02)00706-1  0.668
2002 Smogorzewska A, Karlseder J, Holtgreve-Grez H, Jauch A, de Lange T. DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2. Current Biology : Cb. 12: 1635-44. PMID 12361565 DOI: 10.1016/S0960-9822(02)01179-X  0.796
2002 Karlseder J, Smogorzewska A, de Lange T. Senescence induced by altered telomere state, not telomere loss. Science (New York, N.Y.). 295: 2446-9. PMID 11923537 DOI: 10.1126/Science.1069523  0.784
1999 Karlseder J, Broccoli D, Dai Y, Hardy S, de Lange T. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science (New York, N.Y.). 283: 1321-5. PMID 10037601 DOI: 10.1126/Science.283.5406.1321  0.767
1998 Wolschek MF, Narendja F, Karlseder J, Kubicek CP, Scazzocchio C, Strauss J. In situ detection of protein-DNA interactions in filamentous fungi by in vivo footprinting. Nucleic Acids Research. 26: 3862-4. PMID 9685506 DOI: 10.1093/Nar/26.16.3862  0.396
1997 Orel L, Simon MM, Karlseder J, Bhardwaj R, Trautinger F, Schwarz T, Luger TA. alpha-Melanocyte stimulating hormone downregulates differentiation-driven heat shock protein 70 expression in keratinocytes. The Journal of Investigative Dermatology. 108: 401-5. PMID 9077466 DOI: 10.1111/1523-1747.Ep12289699  0.313
1996 Sutterluety H, Bartl S, Karlseder J, Wintersberger E, Seiser C. Carboxy-terminal residues of mouse thymidine kinase are essential for rapid degradation in quiescent cells. Journal of Molecular Biology. 259: 383-92. PMID 8676376 DOI: 10.1006/Jmbi.1996.0327  0.337
1996 Karlseder J, Rotheneder H, Wintersberger E. Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F. Molecular and Cellular Biology. 16: 1659-67. PMID 8657141 DOI: 10.1128/Mcb.16.4.1659  0.336
1996 Karlseder J, Wissing D, Holzer G, Orel L, Sliutz G, Auer H, Jäättelä M, Simon MM. HSP70 overexpression mediates the escape of a doxorubicin-induced G2 cell cycle arrest. Biochemical and Biophysical Research Communications. 220: 153-9. PMID 8602836 DOI: 10.1006/Bbrc.1996.0373  0.393
1994 Karlseder J, Zeillinger R, Schneeberger C, Czerwenka K, Speiser P, Kubista E, Birnbaum D, Gaudray P, Theillet C. Patterns of DNA amplification at band q13 of chromosome 11 in human breast cancer. Genes, Chromosomes & Cancer. 9: 42-8. PMID 7507699 DOI: 10.1002/Gcc.2870090108  0.392
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