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Eckhard Mandelkow, PhD - Publications

Affiliations: 
Max-Planck Unit for Structural Molecular Biology at DESY, Hamburg, Hamburg, Hamburg, Germany 
Area:
http://www.researchprofiles.collexis.com/jad/expert.asp?u_id=60
Website:
http://www.mpg.de/299986/strukturelle_molekularbiologie_wissM2
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335 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Anglada-Huguet M, Endepols H, Sydow A, Hilgers R, Neumaier B, Drzezga A, Kaniyappan S, Mandelkow E, Mandelkow EM. Reversal of Tau-Dependent Cognitive Decay by Blocking Adenosine A1 Receptors: Comparison of Transgenic Mouse Models with Different Levels of Tauopathy. International Journal of Molecular Sciences. 24. PMID 37298211 DOI: 10.3390/ijms24119260  0.813
2023 Prince PR, Hochmair J, Brognaro H, Gevorgyan S, Franck M, Schubert R, Lorenzen K, Yazici S, Mandelkow E, Wegmann S, Betzel C. Initiation and modulation of Tau protein phase separation by the drug suramin. Scientific Reports. 13: 3963. PMID 36894559 DOI: 10.1038/s41598-023-29846-9  0.772
2022 Hochmair J, Exner C, Betzel C, Mandelkow E, Wegmann S. Light Microscopy and Dynamic Light Scattering to Study Liquid-Liquid Phase Separation of Tau Proteins In Vitro. Methods in Molecular Biology (Clifton, N.J.). 2551: 225-243. PMID 36310206 DOI: 10.1007/978-1-0716-2597-2_15  0.769
2022 Kaniyappan S, Balaji V, Wang Y, Mandelkow E. Microfluidic Chamber Technology to Study Missorting and Spreading of Tau Protein in Alzheimer's Disease. Methods in Molecular Biology (Clifton, N.J.). 2551: 111-123. PMID 36310200 DOI: 10.1007/978-1-0716-2597-2_9  0.819
2022 Hochmair J, Exner C, Franck M, Dominguez-Baquero A, Diez L, Brognaro H, Kraushar ML, Mielke T, Radbruch H, Kaniyappan S, Falke S, Mandelkow E, Betzel C, Wegmann S. Molecular crowding and RNA synergize to promote phase separation, microtubule interaction, and seeding of Tau condensates. The Embo Journal. e108882. PMID 35298090 DOI: 10.15252/embj.2021108882  0.849
2022 Wischhof L, Adhikari A, Mondal M, Marsal-Cots A, Biernat J, Mandelkow EM, Mandelkow E, Ehninger D, Nicotera P, Bano D. Unbiased proteomic profiling reveals the IP3R modulator AHCYL1/IRBIT as a novel interactor of microtubule-associated protein tau. The Journal of Biological Chemistry. 298: 101774. PMID 35218773 DOI: 10.1016/j.jbc.2022.101774  0.456
2022 Aillaud I, Kaniyappan S, Chandupatla RR, Ramirez LM, Alkhashrom S, Eichler J, Horn AHC, Zweckstetter M, Mandelkow E, Sticht H, Funke SA. A novel D-amino acid peptide with therapeutic potential (ISAD1) inhibits aggregation of neurotoxic disease-relevant mutant Tau and prevents Tau toxicity in vitro. Alzheimer's Research & Therapy. 14: 15. PMID 35063014 DOI: 10.1186/s13195-022-00959-z  0.816
2021 Sallaberry CA, Voss BJ, Majewski J, Biernat J, Mandelkow E, Chi EY, Vander Zanden CM. Tau and Membranes: Interactions That Promote Folding and Condensation. Frontiers in Cell and Developmental Biology. 9: 725241. PMID 34621743 DOI: 10.3389/fcell.2021.725241  0.391
2021 Malhis M, Kaniyappan S, Aillaud I, Chandupatla RR, Ramirez LM, Zweckstetter M, Horn AHC, Mandelkow E, Sticht H, Funke SA. Potent Tau aggregation inhibitor D-peptides selected against Tau-repeat 2 using mirror image phage display. Chembiochem : a European Journal of Chemical Biology. PMID 34375027 DOI: 10.1002/cbic.202100287  0.806
2021 Anglada-Huguet M, Rodrigues S, Hochgräfe K, Mandelkow E, Mandelkow EM. Inhibition of Tau aggregation with BSc3094 reduces Tau and decreases cognitive deficits in rTg4510 mice. Alzheimer's & Dementia (New York, N. Y.). 7: e12170. PMID 34095439 DOI: 10.1002/trc2.12170  0.494
2021 Wegmann S, Biernat J, Mandelkow E. A current view on Tau protein phosphorylation in Alzheimer's disease. Current Opinion in Neurobiology. 69: 131-138. PMID 33892381 DOI: 10.1016/j.conb.2021.03.003  0.777
2020 Drepper F, Biernat J, Kaniyappan S, Meyer HE, Mandelkow EM, Warscheid B, Mandelkow E. A combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human Tau but minimal levels of other key modifications. The Journal of Biological Chemistry. 295: 18213-18225. PMID 33453828 DOI: 10.1074/jbc.RA120.015882  0.403
2020 Savastano A, Jaipuria G, Andreas L, Mandelkow E, Zweckstetter M. Solid-state NMR investigation of the involvement of the P2 region in tau amyloid fibrils. Scientific Reports. 10: 21210. PMID 33273615 DOI: 10.1038/s41598-020-78161-0  0.49
2020 Drepper F, Biernat J, Kaniyappan S, Meyer HE, Mandelkow EM, Warscheid B, Mandelkow E. A combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human tau but minimal levels of other key modifications. The Journal of Biological Chemistry. PMID 33106314 DOI: 10.1074/jbc.RA120.015882  0.8
2020 Savastano A, Flores D, Kadavath H, Biernat J, Mandelkow E, Zweckstetter M. Disease-associated tau phosphorylation hinders tubulin assembly within tau condensates. Angewandte Chemie (International Ed. in English). PMID 33017094 DOI: 10.1002/anie.202011157  0.515
2020 Ukmar-Godec T, Fang P, Ibáñez de Opakua A, Henneberg F, Godec A, Pan KT, Cima-Omori MS, Chari A, Mandelkow E, Urlaub H, Zweckstetter M. Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution. Science Advances. 6: eaba3916. PMID 32832664 DOI: 10.1126/Sciadv.Aba3916  0.582
2020 Majewski J, Jones EM, Vander Zanden CM, Biernat J, Mandelkow E, Chi EY. Lipid membrane templated misfolding and self-assembly of intrinsically disordered tau protein. Scientific Reports. 10: 13324. PMID 32770092 DOI: 10.1038/S41598-020-70208-6  0.521
2020 Kaniyappan S, Tepper K, Biernat J, Chandupatla RR, Hübschmann S, Irsen S, Bicher S, Klatt C, Mandelkow EM, Mandelkow E. FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments. Molecular Neurodegeneration. 15: 39. PMID 32677995 DOI: 10.1186/S13024-020-00389-1  0.849
2019 Zempel H, Mandelkow E. Mechanisms of Axonal Sorting of Tau and Influence of the Axon Initial Segment on Tau Cell Polarity. Advances in Experimental Medicine and Biology. 1184: 69-77. PMID 32096029 DOI: 10.1007/978-981-32-9358-8_6  0.458
2019 Ambadipudi S, Reddy JG, Biernat J, Mandelkow E, Zweckstetter M. Residue-specific identification of phase separation hot spots of Alzheimer's-related protein tau. Chemical Science. 10: 6503-6507. PMID 31341602 DOI: 10.1039/C9Sc00531E  0.462
2019 Ukmar-Godec T, Hutten S, Grieshop MP, Rezaei-Ghaleh N, Cima-Omori MS, Biernat J, Mandelkow E, Söding J, Dormann D, Zweckstetter M. Lysine/RNA-interactions drive and regulate biomolecular condensation. Nature Communications. 10: 2909. PMID 31266957 DOI: 10.1038/S41467-019-10792-Y  0.351
2019 Green C, Sydow A, Vogel S, Anglada-Huguet M, Wiedermann D, Mandelkow E, Mandelkow EM, Hoehn M. Functional networks are impaired by elevated tau-protein but reversible in a regulatable Alzheimer's disease mouse model. Molecular Neurodegeneration. 14: 13. PMID 30917861 DOI: 10.1186/S13024-019-0316-6  0.555
2019 Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburg CR, ... ... Mandelkow E, et al. Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron. 101: 349. PMID 30653936 DOI: 10.1016/J.Neuron.2018.12.031  0.757
2018 Pickhardt M, Tassoni M, Denner P, Kurkowsky B, Kitanovic A, Möhl C, Fava E, Mandelkow E. Screening of a neuronal cell model of tau pathology for therapeutic compounds. Neurobiology of Aging. 76: 24-34. PMID 30640040 DOI: 10.1016/J.Neurobiolaging.2018.11.026  0.529
2018 Pellkofer H, Ihler F, Weiss BG, Trothe J, Kadavath H, Chongtham M, Kunadt M, Riedel D, Lornsen F, Wilken P, Bartels C, Hirschel S, Russo SG, Stransky E, Trojan L, ... ... Mandelkow E, et al. Evaluation of the methoxy-X04 derivative BSC4090 for diagnosis of prodromal and early Alzheimer's disease from bioptic olfactory mucosa. European Archives of Psychiatry and Clinical Neuroscience. PMID 30421149 DOI: 10.1007/s00406-018-0955-6  0.303
2018 Oroz J, Chang BJ, Wysoczanski P, Lee CT, Pérez-Lara Á, Chakraborty P, Hofele RV, Baker JD, Blair LJ, Biernat J, Urlaub H, Mandelkow E, Dickey CA, Zweckstetter M. Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex. Nature Communications. 9: 4532. PMID 30382094 DOI: 10.1038/s41467-018-06880-0  0.307
2018 Pir GJ, Choudhary B, Kaniyappan S, Chandupatla RR, Mandelkow E, Mandelkow EM, Wang Y. Suppressing Tau Aggregation and Toxicity by an Anti-Aggregant Tau Fragment. Molecular Neurobiology. PMID 30196394 DOI: 10.1007/S12035-018-1326-Z  0.841
2018 Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburgh CR, ... ... Mandelkow E, et al. Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron. 99: 925-940.e7. PMID 30189209 DOI: 10.1016/J.Neuron.2018.07.039  0.808
2018 Balaji V, Kaniyappan S, Mandelkow E, Wang Y, Mandelkow EM. Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems. Autophagy. PMID 30145931 DOI: 10.1080/15548627.2018.1509607  0.785
2018 Remmler D, Schwaar T, Pickhardt M, Donth C, Mandelkow E, Weller MG, Börner HG. On the way to precision formulation additives: 2D-screening to select solubilizers with tailored host and release capabilities. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 29964137 DOI: 10.1016/J.Jconrel.2018.06.032  0.366
2018 Kiss R, Csizmadia G, Solti K, Keresztes A, Zhu M, Pickhardt M, Mandelkow E, Toth G. The structural basis of small molecule targetability of monomeric Tau protein. Acs Chemical Neuroscience. PMID 29944336 DOI: 10.1021/Acschemneuro.8B00182  0.477
2018 Choudhary B, Mandelkow E, Mandelkow EM, Pir GJ. Glutamatergic nervous system degeneration in a C. elegans. Tau tauopathy model involves pathways of excitotoxicity and Ca dysregulation. Neurobiology of Disease. PMID 29894752 DOI: 10.1016/J.Nbd.2018.06.005  0.45
2018 Kaniyappan S, Chandupatla RR, Mandelkow E. Purification and Characterization of Low-n Tau Oligomers. Methods in Molecular Biology (Clifton, N.J.). 1779: 99-111. PMID 29886530 DOI: 10.1007/978-1-4939-7816-8_8  0.831
2018 Mari SA, Wegmann S, Tepper K, Hyman BT, Mandelkow EM, Mandelkow E, Müller DJ. Reversible Cation-Selective Attachment and Self-Assembly of Human Tau on Supported Brain Lipid Membranes. Nano Letters. PMID 29644863 DOI: 10.1021/Acs.Nanolett.8B01085  0.758
2018 Wegmann S, Eftekharzadeh B, Tepper K, Zoltowska KM, Bennett RE, Dujardin S, Laskowski PR, MacKenzie D, Kamath T, Commins C, Vanderburg C, Roe AD, Fan Z, Molliex AM, Hernandez-Vega A, ... ... Mandelkow E, et al. Tau protein liquid-liquid phase separation can initiate tau aggregation. The Embo Journal. PMID 29472250 DOI: 10.15252/Embj.201798049  0.799
2018 Kadavath H, Cabrales Fontela Y, Jaremko M, Jaremko L, Overkamp K, Biernat J, Mandelkow E, Zweckstetter M. The binding mode of a repeat-like Tau sequence with tubulin. Angewandte Chemie (International Ed. in English). PMID 29314492 DOI: 10.1002/Anie.201712089  0.504
2018 Kadavath H, Fontela YC, Jaremko M, Jaremko Ł, Overkamp K, Biernat J, Mandelkow E, Zweckstetter M. Der Bindungsmodus eines Tau-Peptids mit Tubulin Angewandte Chemie. 130: 3301-3305. DOI: 10.1002/Ange.201712089  0.401
2017 Mudher A, Colin M, Dujardin S, Medina M, Dewachter I, Naini SMA, Mandelkow EM, Mandelkow E, Buée L, Goedert M, Brion JP. What is the evidence that tau pathology spreads through prion-like propagation? Acta Neuropathologica Communications. 5: 99. PMID 29258615 DOI: 10.1186/S40478-017-0488-7  0.49
2017 Cabrales Fontela Y, Kadavath H, Biernat J, Riedel D, Mandelkow E, Zweckstetter M. Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau. Nature Communications. 8: 1981. PMID 29215007 DOI: 10.1038/S41467-017-02230-8  0.514
2017 Joseph M, Anglada-Huguet M, Paesler K, Mandelkow E, Mandelkow EM. Anti-aggregant tau mutant promotes neurogenesis. Molecular Neurodegeneration. 12: 88. PMID 29202785 DOI: 10.1186/s13024-017-0230-8  0.459
2017 Pir GJ, Choudhary B, Mandelkow E. Caenorhabditis elegans models of tauopathy. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 31: 5137-5148. PMID 29191965 DOI: 10.1096/fj.201701007  0.387
2017 Sotiropoulos I, Galas MC, Silva JM, Skoulakis E, Wegmann S, Maina MB, Blum D, Sayas CL, Mandelkow EM, Mandelkow E, Spillantini MG, Sousa N, Avila J, Medina M, Mudher A, et al. Atypical, non-standard functions of the microtubule associated Tau protein. Acta Neuropathologica Communications. 5: 91. PMID 29187252 DOI: 10.1186/S40478-017-0489-6  0.757
2017 Caballero B, Wang Y, Diaz A, Tasset I, Juste YR, Mandelkow EM, Mandelkow E, Cuervo AM. Interplay of pathogenic forms of human tau with different autophagic pathways. Aging Cell. PMID 29024336 DOI: 10.1111/Acel.12692  0.445
2017 Ambadipudi S, Biernat J, Riedel D, Mandelkow E, Zweckstetter M. Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau. Nature Communications. 8: 275. PMID 28819146 DOI: 10.1038/S41467-017-00480-0  0.524
2017 Baker JD, Shelton LB, Zheng D, Favretto F, Nordhues BA, Darling A, Sullivan LE, Sun Z, Solanki PK, Martin MD, Suntharalingam A, Sabbagh JJ, Becker S, Mandelkow E, Uversky VN, et al. Human cyclophilin 40 unravels neurotoxic amyloids. Plos Biology. 15: e2001336. PMID 28654636 DOI: 10.1371/Journal.Pbio.2001336  0.526
2017 Pickhardt M, Biernat J, Hübschmann S, Dennissen FJA, Timm T, Aho A, Mandelkow EM, Mandelkow E. Time course of Tau toxicity and pharmacologic prevention in a cell model of Tauopathy. Neurobiology of Aging. 57: 47-63. PMID 28600952 DOI: 10.1016/J.Neurobiolaging.2017.04.022  0.568
2017 Zempel H, Dennissen F, Kumar Y, Luedtke J, Biernat J, Mandelkow EM, Mandelkow E. Axodendritic sorting and pathological missorting of Tau is isoform specific and determined by axon initial segment architecture. The Journal of Biological Chemistry. PMID 28536263 DOI: 10.1074/Jbc.M117.784702  0.541
2017 Kaniyappan S, Chandupatla RR, Mandelkow EM, Mandelkow E. Extracellular low-n oligomers of tau cause selective synaptotoxicity without affecting cell viability. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 28528849 DOI: 10.1016/J.Jalz.2017.04.002  0.824
2017 Lawatscheck C, Pickhardt M, Grafl A, Linkert K, Polster F, Mandelkow E, Börner HG. Gaining Insights into Specific Drug Formulation Additives for Solubilizing a Potential Anti-Alzheimer Disease Drug B4A1. Macromolecular Bioscience. PMID 28488401 DOI: 10.1002/Mabi.201700109  0.301
2017 Pickhardt M, Lawatscheck C, Börner HG, Mandelkow E. Inhibition of Tau protein aggregation by rhodanine-based compounds solubilized via specific formulation additives to improve bioavailability and cell viability. Current Alzheimer Research. PMID 28155596 DOI: 10.2174/1567205014666170202103136  0.56
2017 Xiang S, Kulminskaya N, Habenstein B, Biernat J, Tepper K, Paulat M, Griesinger C, Becker S, Lange A, Mandelkow E, Linser R. A two-component adhesive: Tau fibrils arise from a combination of a well-defined motif and conformationally flexible interactions. Journal of the American Chemical Society. PMID 28124562 DOI: 10.1021/Jacs.6B09619  0.49
2017 Wang Y, Balaji V, Kaniyappan S, Krüger L, Irsen S, Tepper K, Chandupatla R, Maetzler W, Schneider A, Mandelkow E, Mandelkow EM. The release and trans-synaptic transmission of Tau via exosomes. Molecular Neurodegeneration. 12: 5. PMID 28086931 DOI: 10.1186/S13024-016-0143-Y  0.824
2016 Dammers C, Yolcu D, Kukuk L, Willbold D, Pickhardt M, Mandelkow E, Horn AH, Sticht H, Malhis MN, Will N, Schuster J, Funke SA. Selection and Characterization of Tau Binding ᴅ-Enantiomeric Peptides with Potential for Therapy of Alzheimer Disease. Plos One. 11: e0167432. PMID 28006031 DOI: 10.1371/Journal.Pone.0167432  0.494
2016 Dennissen FJ, Anglada-Huguet M, Sydow A, Mandelkow E, Mandelkow EM. Adenosine A1 receptor antagonist rolofylline alleviates axonopathy caused by human Tau ΔK280. Proceedings of the National Academy of Sciences of the United States of America. PMID 27671637 DOI: 10.1073/pnas.1603119113  0.442
2016 Holtzman DM, Carrillo MC, Hendrix JA, Bain LJ, Catafau AM, Gault LM, Goedert M, Mandelkow E, Mandelkow EM, Miller DS, Ostrowitzki S, Polydoro M, Smith S, Wittmann M, Hutton M. Tau: From research to clinical development. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27154059 DOI: 10.1016/J.Jalz.2016.03.018  0.498
2016 Pir GJ, Choudhary B, Mandelkow E, Mandelkow EM. Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model. Molecular Neurodegeneration. 11: 33. PMID 27118310 DOI: 10.1186/s13024-016-0096-1  0.476
2016 Akoury E, Mukrasch MD, Biernat J, Tepper K, Ozenne V, Mandelkow E, Blackledge M, Zweckstetter M. Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer. Protein Science : a Publication of the Protein Society. PMID 26940799 DOI: 10.1002/pro.2911  0.531
2016 Gorsky MK, Burnouf S, Dols J, Mandelkow E, Partridge L. Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo. Scientific Reports. 6: 22685. PMID 26940749 DOI: 10.1038/srep22685  0.343
2016 Decker JM, Krüger L, Sydow A, Dennissen F, Siskovà Z, Mandelkow E, Mandelkow EM. The Tau/A152T mutation, a risk factor for frontotemporal-spectrum disorders, leads to NR2B receptor-mediated excitotoxicity. Embo Reports. PMID 26931569 DOI: 10.15252/Embr.201541439  0.353
2016 Mair W, Muntel J, Tepper K, Tang S, Biernat J, Seeley WW, Kosik KS, Mandelkow E, Steen H, Steen JA. FLEXITau: Quantifying Post-translational Modifications of Tau Protein in vitro and in Human Disease. Analytical Chemistry. PMID 26877193 DOI: 10.1021/Acs.Analchem.5B04509  0.496
2016 Xiang S, Biernat J, Mandelkow E, Becker S, Linser R. Backbone assignment for minimal protein amounts of low structural homogeneity in the absence of deuteration. Chemical Communications (Cambridge, England). PMID 26806645 DOI: 10.1039/C5Cc09160H  0.372
2016 Mandelkow E. Structural constraints for the spreading of tau pathology Neurobiology of Aging. 39: S24. DOI: 10.1016/J.Neurobiolaging.2016.01.108  0.507
2016 Funke S, Dammers C, Pickhardt M, Willbold D, Mandelkow E. Tau-specific D-enantiomeric peptides for therapeutic applications in Alzheimer’s disease Neurobiology of Aging. 39. DOI: 10.1016/J.Neurobiolaging.2016.01.066  0.375
2015 Wang Y, Mandelkow E. Tau in physiology and pathology. Nature Reviews. Neuroscience. PMID 26631930 DOI: 10.1038/Nrn.2015.1  0.623
2015 Pickhardt M, Neumann T, Schwizer D, Callaway K, Vendruscolo M, Schenk D, George-Hyslop PS, Mandelkow EM, Dobson CM, McConlogue L, Mandelkow E, Toth G. Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies. Current Alzheimer Research. 12: 814-28. PMID 26510979 DOI: 10.2174/156720501209151019104951  0.48
2015 Yamada K, Patel TK, Hochgräfe K, Mahan TE, Jiang H, Stewart FR, Mandelkow EM, Holtzman DM. Analysis of in vivo turnover of tau in a mouse model of tauopathy. Molecular Neurodegeneration. 10: 55. PMID 26502977 DOI: 10.1186/S13024-015-0052-5  0.473
2015 Krüger L, Mandelkow EM. Tau neurotoxicity and rescue in animal models of human Tauopathies. Current Opinion in Neurobiology. 36: 52-58. PMID 26431808 DOI: 10.1016/j.conb.2015.09.004  0.499
2015 Schwalbe M, Kadavath H, Biernat J, Ozenne V, Blackledge M, Mandelkow E, Zweckstetter M. Structural Impact of Tau Phosphorylation at Threonine 231. Structure (London, England : 1993). 23: 1448-58. PMID 26165593 DOI: 10.1016/J.Str.2015.06.002  0.529
2015 Kadavath H, Jaremko M, Jaremko Ł, Biernat J, Mandelkow E, Zweckstetter M. Folding of the Tau Protein on Microtubules. Angewandte Chemie (International Ed. in English). 54: 10347-51. PMID 26094605 DOI: 10.1002/Anie.201501714  0.551
2015 Kadavath H, Hofele RV, Biernat J, Kumar S, Tepper K, Urlaub H, Mandelkow E, Zweckstetter M. Tau stabilizes microtubules by binding at the interface between tubulin heterodimers. Proceedings of the National Academy of Sciences of the United States of America. 112: 7501-6. PMID 26034266 DOI: 10.1073/Pnas.1504081112  0.558
2015 Hochgräfe K, Sydow A, Matenia D, Cadinu D, Könen S, Petrova O, Pickhardt M, Goll P, Morellini F, Mandelkow E, Mandelkow EM. Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau. Acta Neuropathologica Communications. 3: 25. PMID 25958115 DOI: 10.1186/S40478-015-0204-4  0.529
2015 Shammas SL, Garcia GA, Kumar S, Kjaergaard M, Horrocks MH, Shivji N, Mandelkow E, Knowles TP, Mandelkow E, Klenerman D. A mechanistic model of tau amyloid aggregation based on direct observation of oligomers. Nature Communications. 6: 7025. PMID 25926130 DOI: 10.1038/Ncomms8025  0.559
2015 Decker JM, Krüger L, Sydow A, Zhao S, Frotscher M, Mandelkow E, Mandelkow EM. Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca(++) dysregulation. Acta Neuropathologica Communications. 3: 23. PMID 25853683 DOI: 10.1186/S40478-015-0193-3  0.498
2015 Saidi LJ, Polydoro M, Kay KR, Sanchez L, Mandelkow EM, Hyman BT, Spires-Jones TL. Carboxy terminus heat shock protein 70 interacting protein reduces tau-associated degenerative changes. Journal of Alzheimer's Disease : Jad. 44: 937-47. PMID 25374103 DOI: 10.3233/Jad-142094  0.637
2015 Zempel H, Mandelkow EM. Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia Molecular Neurodegeneration. 10. DOI: 10.1186/s13024-015-0064-1  0.47
2015 Kadavath H, Jaremko M, Jaremko L, Biernat J, Mandelkow E, Zweckstetter M. Folding of Tau on microtubules. Angewandte Chemie. DOI: 10.1002/Anie.201501714/Epdf  0.563
2015 Kadavath H, Jaremko M, Jaremko ?, Biernat J, Mandelkow E, Zweckstetter M. Folding of the Tau Protein on Microtubules Angewandte Chemie - International Edition. DOI: 10.1002/anie.201501714  0.445
2015 Kadavath H, Jaremko M, Jaremko Ł, Biernat J, Mandelkow E, Zweckstetter M. Faltungszustand des Proteins Tau bei Bindung an Mikrotubuli Angewandte Chemie. 127: 10488-10492. DOI: 10.1002/Ange.201501714  0.476
2014 Tepper K, Biernat J, Kumar S, Wegmann S, Timm T, Hübschmann S, Redecke L, Mandelkow EM, Müller DJ, Mandelkow E. Oligomer formation of tau protein hyperphosphorylated in cells. The Journal of Biological Chemistry. 289: 34389-407. PMID 25339173 DOI: 10.1074/Jbc.M114.611368  0.779
2014 Zempel H, Mandelkow E. Lost after translation: missorting of Tau protein and consequences for Alzheimer disease. Trends in Neurosciences. 37: 721-32. PMID 25223701 DOI: 10.1016/J.Tins.2014.08.004  0.616
2014 Grüning CS, Mirecka EA, Klein AN, Mandelkow E, Willbold D, Marino SF, Stoldt M, Hoyer W. Alternative conformations of the Tau repeat domain in complex with an engineered binding protein. The Journal of Biological Chemistry. 289: 23209-18. PMID 24966331 DOI: 10.1074/Jbc.M114.560920  0.559
2014 Kumar S, Tepper K, Kaniyappan S, Biernat J, Wegmann S, Mandelkow EM, Müller DJ, Mandelkow E. Stages and conformations of the Tau repeat domain during aggregation and its effect on neuronal toxicity. The Journal of Biological Chemistry. 289: 20318-32. PMID 24825901 DOI: 10.1074/Jbc.M114.554725  0.836
2014 Scholz T, Mandelkow E. Transport and diffusion of Tau protein in neurons. Cellular and Molecular Life Sciences : Cmls. 71: 3139-50. PMID 24687422 DOI: 10.1007/S00018-014-1610-7  0.44
2014 Karagöz GE, Duarte AM, Akoury E, Ippel H, Biernat J, Morán Luengo T, Radli M, Didenko T, Nordhues BA, Veprintsev DB, Dickey CA, Mandelkow E, Zweckstetter M, Boelens R, Madl T, et al. Hsp90-Tau complex reveals molecular basis for specificity in chaperone action. Cell. 156: 963-74. PMID 24581495 DOI: 10.1016/J.Cell.2014.01.037  0.365
2014 Yamada K, Holth JK, Liao F, Stewart FR, Mahan TE, Jiang H, Cirrito JR, Patel TK, Hochgräfe K, Mandelkow EM, Holtzman DM. Neuronal activity regulates extracellular tau in vivo. The Journal of Experimental Medicine. 211: 387-93. PMID 24534188 DOI: 10.1085/Jgp.1434Oia12  0.384
2014 Schwalbe M, Ozenne V, Bibow S, Jaremko M, Jaremko L, Gajda M, Jensen MR, Biernat J, Becker S, Mandelkow E, Zweckstetter M, Blackledge M. Predictive atomic resolution descriptions of intrinsically disordered hTau40 and α-synuclein in solution from NMR and small angle scattering. Structure (London, England : 1993). 22: 238-49. PMID 24361273 DOI: 10.1016/J.Str.2013.10.020  0.354
2014 Michel CH, Kumar S, Pinotsi D, Tunnacliffe A, St George-Hyslop P, Mandelkow E, Mandelkow EM, Kaminski CF, Kaminski Schierle GS. Extracellular monomeric tau protein is sufficient to initiate the spread of tau protein pathology. The Journal of Biological Chemistry. 289: 956-67. PMID 24235150 DOI: 10.1074/Jbc.M113.515445  0.628
2013 Schwalbe M, Biernat J, Bibow S, Ozenne V, Jensen MR, Kadavath H, Blackledge M, Mandelkow E, Zweckstetter M. Phosphorylation of human Tau protein by microtubule affinity-regulating kinase 2. Biochemistry. 52: 9068-79. PMID 24251416 DOI: 10.1021/Bi401266N  0.558
2013 Zempel H, Luedtke J, Kumar Y, Biernat J, Dawson H, Mandelkow E, Mandelkow EM. Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin. The Embo Journal. 32: 2920-37. PMID 24065130 DOI: 10.1038/Emboj.2013.207  0.589
2013 Hochgräfe K, Sydow A, Mandelkow EM. Regulatable transgenic mouse models of Alzheimer disease: onset, reversibility and spreading of Tau pathology. The Febs Journal. 280: 4371-81. PMID 23517246 DOI: 10.1111/febs.12250  0.515
2013 Bulic B, Pickhardt M, Mandelkow E. Progress and developments in tau aggregation inhibitors for Alzheimer disease. Journal of Medicinal Chemistry. 56: 4135-55. PMID 23484434 DOI: 10.1021/Jm3017317  0.504
2013 Akoury E, Pickhardt M, Gajda M, Biernat J, Mandelkow E, Zweckstetter M. Mechanistic basis of phenothiazine-driven inhibition of Tau aggregation. Angewandte Chemie (International Ed. in English). 52: 3511-5. PMID 23401175 DOI: 10.1002/Anie.201208290  0.522
2013 Akoury E, Gajda M, Pickhardt M, Biernat J, Soraya P, Griesinger C, Mandelkow E, Zweckstetter M. Inhibition of tau filament formation by conformational modulation. Journal of the American Chemical Society. 135: 2853-62. PMID 23360400 DOI: 10.1021/Ja312471H  0.6
2013 Jinwal UK, Akoury E, Abisambra JF, O'Leary JC, Thompson AD, Blair LJ, Jin Y, Bacon J, Nordhues BA, Cockman M, Zhang J, Li P, Zhang B, Borysov S, Uversky VN, ... ... Mandelkow E, et al. Imbalance of Hsp70 family variants fosters tau accumulation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 1450-9. PMID 23271055 DOI: 10.1096/Fj.12-220889  0.482
2013 Wegmann S, Medalsy ID, Mandelkow E, Müller DJ. The fuzzy coat of pathological human Tau fibrils is a two-layered polyelectrolyte brush. Proceedings of the National Academy of Sciences of the United States of America. 110: E313-21. PMID 23269837 DOI: 10.1073/Pnas.1212100110  0.74
2013 Messing L, Decker JM, Joseph M, Mandelkow E, Mandelkow EM. Cascade of tau toxicity in inducible hippocampal brain slices and prevention by aggregation inhibitors. Neurobiology of Aging. 34: 1343-54. PMID 23158765 DOI: 10.1016/J.Neurobiolaging.2012.10.024  0.559
2013 Mandelkow EM, Sydow A, Hochgräfe K, Kumar Y, Zempel H, Mandelkow E. S.04.02 Tau, axonal transport and Alzheimer's disease European Neuropsychopharmacology. 23. DOI: 10.1016/S0924-977X(13)70135-4  0.403
2012 Holtzman DM, Mandelkow E, Selkoe DJ. Alzheimer disease in 2020. Cold Spring Harbor Perspectives in Medicine. 2. PMID 23125202 DOI: 10.1101/Cshperspect.A011585  0.335
2012 Hinrichs MH, Jalal A, Brenner B, Mandelkow E, Kumar S, Scholz T. Tau protein diffuses along the microtubule lattice. The Journal of Biological Chemistry. 287: 38559-68. PMID 23019339 DOI: 10.1074/Jbc.M112.369785  0.48
2012 Daebel V, Chinnathambi S, Biernat J, Schwalbe M, Habenstein B, Loquet A, Akoury E, Tepper K, Müller H, Baldus M, Griesinger C, Zweckstetter M, Mandelkow E, Vijayan V, Lange A. β-Sheet core of tau paired helical filaments revealed by solid-state NMR. Journal of the American Chemical Society. 134: 13982-9. PMID 22862303 DOI: 10.1021/Ja305470P  0.484
2012 Wang Y, Mandelkow E. Degradation of tau protein by autophagy and proteasomal pathways. Biochemical Society Transactions. 40: 644-52. PMID 22817709 DOI: 10.1042/Bst20120071  0.593
2012 Mandelkow EM, Mandelkow E. Biochemistry and cell biology of tau protein in neurofibrillary degeneration. Cold Spring Harbor Perspectives in Medicine. 2: a006247. PMID 22762014 DOI: 10.1101/Cshperspect.A006247  0.618
2012 Fatouros C, Pir GJ, Biernat J, Koushika SP, Mandelkow E, Mandelkow EM, Schmidt E, Baumeister R. Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity. Human Molecular Genetics. 21: 3587-603. PMID 22611162 DOI: 10.1093/Hmg/Dds190  0.576
2012 Coppola G, Chinnathambi S, Lee JJ, Dombroski BA, Baker MC, Soto-Ortolaza AI, Lee SE, Klein E, Huang AY, Sears R, Lane JR, Karydas AM, Kenet RO, Biernat J, Wang LS, ... ... Mandelkow EM, ... ... Mandelkow E, et al. Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Human Molecular Genetics. 21: 3500-12. PMID 22556362 DOI: 10.1093/Hmg/Dds161  0.489
2012 Van der Jeugd A, Hochgräfe K, Ahmed T, Decker JM, Sydow A, Hofmann A, Wu D, Messing L, Balschun D, D'Hooge R, Mandelkow EM. Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau. Acta Neuropathologica. 123: 787-805. PMID 22532069 DOI: 10.1007/s00401-012-0987-3  0.392
2012 Wegmann S, Muller DJ, Mandelkow E. Investigating fibrillar aggregates of Tau protein by atomic force microscopy. Methods in Molecular Biology (Clifton, N.J.). 849: 169-83. PMID 22528090 DOI: 10.1007/978-1-61779-551-0_12  0.709
2012 Jeganathan S, Chinnathambi S, Mandelkow EM, Mandelkow E. Conformations of microtubule-associated protein Tau mapped by fluorescence resonance energy transfer. Methods in Molecular Biology (Clifton, N.J.). 849: 85-99. PMID 22528085 DOI: 10.1007/978-1-61779-551-0_7  0.585
2012 Jones EM, Dubey M, Camp PJ, Vernon BC, Biernat J, Mandelkow E, Majewski J, Chi EY. Interaction of tau protein with model lipid membranes induces tau structural compaction and membrane disruption. Biochemistry. 51: 2539-50. PMID 22401494 DOI: 10.1021/Bi201857V  0.451
2012 Selkoe D, Mandelkow E, Holtzman D. Deciphering Alzheimer disease. Cold Spring Harbor Perspectives in Medicine. 2: a011460. PMID 22315723 DOI: 10.1101/Cshperspect.A011460  0.345
2012 Sapir T, Frotscher M, Levy T, Mandelkow EM, Reiner O. Tau's role in the developing brain: implications for intellectual disability. Human Molecular Genetics. 21: 1681-92. PMID 22194194 DOI: 10.1093/Hmg/Ddr603  0.353
2012 Krüger U, Wang Y, Kumar S, Mandelkow EM. Autophagic degradation of tau in primary neurons and its enhancement by trehalose. Neurobiology of Aging. 33: 2291-305. PMID 22169203 DOI: 10.1016/j.neurobiolaging.2011.11.009  0.494
2012 Zempel H, Mandelkow EM. Linking amyloid-β and tau: amyloid-β induced synaptic dysfunction via local wreckage of the neuronal cytoskeleton. Neuro-Degenerative Diseases. 10: 64-72. PMID 22156588 DOI: 10.1159/000332816  0.474
2012 Hinrichs MH, Jalal A, Brenner B, Mandelkow E, Scholz T. One-Dimensional Diffusion of Tau Protein Guided by the Microtubule Lattice Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.3802  0.489
2011 Li X, Kumar Y, Zempel H, Mandelkow EM, Biernat J, Mandelkow E. Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration. The Embo Journal. 30: 4825-37. PMID 22009197 DOI: 10.1038/Emboj.2011.376  0.522
2011 Bibow S, Mukrasch MD, Chinnathambi S, Biernat J, Griesinger C, Mandelkow E, Zweckstetter M. The dynamic structure of filamentous tau. Angewandte Chemie (International Ed. in English). 50: 11520-4. PMID 21990182 DOI: 10.1002/Anie.201105493  0.461
2011 Timm T, von Kries JP, Li X, Zempel H, Mandelkow E, Mandelkow EM. Microtubule affinity regulating kinase activity in living neurons was examined by a genetically encoded fluorescence resonance energy transfer/fluorescence lifetime imaging-based biosensor: inhibitors with therapeutic potential. The Journal of Biological Chemistry. 286: 41711-22. PMID 21984823 DOI: 10.1074/Jbc.M111.257865  0.401
2011 Yamada K, Cirrito JR, Stewart FR, Jiang H, Finn MB, Holmes BB, Binder LI, Mandelkow EM, Diamond MI, Lee VM, Holtzman DM. In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 13110-7. PMID 21917794 DOI: 10.1523/Jneurosci.2569-11.2011  0.497
2011 Bibow S, Ozenne V, Biernat J, Blackledge M, Mandelkow E, Zweckstetter M. Structural impact of proline-directed pseudophosphorylation at AT8, AT100, and PHF1 epitopes on 441-residue tau. Journal of the American Chemical Society. 133: 15842-5. PMID 21910444 DOI: 10.1021/Ja205836J  0.551
2011 Taghavi A, Nasir S, Pickhardt M, Heyny-von Haussen R, Mall G, Mandelkow E, Mandelkow EM, Schmidt B. N'-benzylidene-benzohydrazides as novel and selective tau-PHF ligands. Journal of Alzheimer's Disease : Jad. 27: 835-43. PMID 21891864 DOI: 10.3233/Jad-2011-111238  0.533
2011 Sydow A, Van der Jeugd A, Zheng F, Ahmed T, Balschun D, Petrova O, Drexler D, Zhou L, Rune G, Mandelkow E, D'Hooge R, Alzheimer C, Mandelkow EM. Reversibility of Tau-related cognitive defects in a regulatable FTD mouse model. Journal of Molecular Neuroscience : Mn. 45: 432-7. PMID 21822709 DOI: 10.1007/S12031-011-9604-5  0.56
2011 Shkumatov AV, Chinnathambi S, Mandelkow E, Svergun DI. Structural memory of natively unfolded tau protein detected by small-angle X-ray scattering. Proteins. 79: 2122-31. PMID 21560166 DOI: 10.1002/Prot.23033  0.507
2011 Wegmann S, Schöler J, Bippes CA, Mandelkow E, Muller DJ. Competing interactions stabilize pro- and anti-aggregant conformations of human Tau. The Journal of Biological Chemistry. 286: 20512-24. PMID 21498513 DOI: 10.1074/Jbc.M111.237875  0.756
2011 Sydow A, Van der Jeugd A, Zheng F, Ahmed T, Balschun D, Petrova O, Drexler D, Zhou L, Rune G, Mandelkow E, D'Hooge R, Alzheimer C, Mandelkow EM. Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 2511-25. PMID 21325519 DOI: 10.1523/Jneurosci.5245-10.2011  0.497
2011 Schirmer RH, Adler H, Pickhardt M, Mandelkow E. "Lest we forget you--methylene blue...". Neurobiology of Aging. 32: 2325.e7-16. PMID 21316815 DOI: 10.1016/J.Neurobiolaging.2010.12.012  0.384
2011 Garg S, Timm T, Mandelkow EM, Mandelkow E, Wang Y. Cleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragment. Neurobiology of Aging. 32: 1-14. PMID 20961659 DOI: 10.1016/J.Neurobiolaging.2010.09.008  0.577
2011 Korhonen P, van Groen T, Thornell A, Kyrylenko S, Soininen ML, Ojala J, Peltomaa E, Tanila H, Salminen A, Mandelkow EM, Soininen H. Characterization of a novel transgenic rat carrying human tau with mutation P301L. Neurobiology of Aging. 32: 2314-5. PMID 20097445 DOI: 10.1016/j.neurobiolaging.2009.12.022  0.32
2011 Mandelkow E, Li X, Marx A, Mandelkow E, Biernat J. O4-04-03: A novel mechanism for axonal sorting of tau protein: A retrograde barrier at the axon initial segment Alzheimer's & Dementia. 7: S689-S689. DOI: 10.1016/J.Jalz.2011.05.1991  0.311
2011 Garg S, Timm T, Mandelkow E, Mandelkow E, Wang Y. Tau cleavage by calpain: The intermediate at Mr 17kD / MW 11kD is metastable but not toxic Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.1576  0.478
2011 Pickhardt M, Mandelkow E, Mandelkow E. P3-057: A novel approach for monitoring tau aggregation in cell models of tauopathy by fluorescence-activated cell sorting (FACS) Alzheimer's & Dementia. 7: S532-S532. DOI: 10.1016/J.Jalz.2011.05.1496  0.393
2010 Zempel H, Thies E, Mandelkow E, Mandelkow EM. Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 11938-50. PMID 20826658 DOI: 10.1523/Jneurosci.2357-10.2010  0.583
2010 Haass C, Mandelkow E. Fyn-tau-amyloid: a toxic triad. Cell. 142: 356-8. PMID 20691893 DOI: 10.1016/J.Cell.2010.07.032  0.537
2010 Narayanan RL, Dürr UH, Bibow S, Biernat J, Mandelkow E, Zweckstetter M. Automatic assignment of the intrinsically disordered protein Tau with 441-residues. Journal of the American Chemical Society. 132: 11906-7. PMID 20687558 DOI: 10.1021/Ja105657F  0.453
2010 Wang Y, Garg S, Mandelkow EM, Mandelkow E. Proteolytic processing of tau. Biochemical Society Transactions. 38: 955-61. PMID 20658984 DOI: 10.1042/Bst0380955  0.621
2010 Wegmann S, Jung YJ, Chinnathambi S, Mandelkow EM, Mandelkow E, Muller DJ. Human Tau isoforms assemble into ribbon-like fibrils that display polymorphic structure and stability. The Journal of Biological Chemistry. 285: 27302-13. PMID 20566652 DOI: 10.1074/Jbc.M110.145318  0.756
2010 Wang Y, Krüger U, Mandelkow E, Mandelkow EM. Generation of tau aggregates and clearance by autophagy in an inducible cell model of tauopathy. Neuro-Degenerative Diseases. 7: 103-7. PMID 20173337 DOI: 10.1159/000285516  0.521
2010 Sydow A, Mandelkow EM. 'Prion-like' propagation of mouse and human tau aggregates in an inducible mouse model of tauopathy. Neuro-Degenerative Diseases. 7: 28-31. PMID 20160454 DOI: 10.1159/000283479  0.471
2010 Bulic B, Pickhardt M, Mandelkow EM, Mandelkow E. Tau protein and tau aggregation inhibitors. Neuropharmacology. 59: 276-89. PMID 20149808 DOI: 10.1016/J.Neuropharm.2010.01.016  0.526
2010 Marx A, Nugoor C, Panneerselvam S, Mandelkow E. Structure and function of polarity-inducing kinase family MARK/Par-1 within the branch of AMPK/Snf1-related kinases. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 1637-48. PMID 20071654 DOI: 10.1096/Fj.09-148064  0.475
2010 Wang Y, Martinez-Vicente M, Krüger U, Kaushik S, Wong E, Mandelkow EM, Cuervo AM, Mandelkow E. Synergy and antagonism of macroautophagy and chaperone-mediated autophagy in a cell model of pathological tau aggregation. Autophagy. 6: 182-3. PMID 20023429 DOI: 10.4161/Auto.6.1.10815  0.584
2010 Mandelkow E, Thies E, Sydow A, Wang Y, Biernat J, Mandelkow E. S.02.03 Tau toxicity in cell and animal models European Neuropsychopharmacology. 20: S162-S163. DOI: 10.1016/S0924-977X(10)70122-X  0.411
2010 Sydow A, Jeugd AVd, Ahmed T, Balschun D, Zheng F, Petrova O, Drexler D, Zhou L, Rune G, Mandelkow E, D'Hooge R, Alzheimer C, Mandelkow EM. Tau-induced defects in hippocampal neuroplasticity, learning and memory are reversible in a regulatable transgenic mouse model Alzheimers & Dementia. 6: 147-148. DOI: 10.1016/J.Jalz.2010.05.489  0.322
2010 Zempel H, Thies E, Mandelkow E, Mandelkow EM. O2-03-08: Abeta oligomers cause local missorting of endogenous tau into dendrites, tau phosphorylation, destruction of microtubules and spines Alzheimer's & Dementia. 6: S102-S102. DOI: 10.1016/J.Jalz.2010.05.321  0.523
2010 Camp P, Biernat J, Mandelkow E, Majewski J, Chi EY. Lipid-Membrane Mediated Tau Misfolding and Aggregation Biophysical Journal. 98: 239a-240a. DOI: 10.1016/J.Bpj.2009.12.1300  0.476
2009 Fischer D, Mukrasch MD, Biernat J, Bibow S, Blackledge M, Griesinger C, Mandelkow E, Zweckstetter M. Conformational changes specific for pseudophosphorylation at serine 262 selectively impair binding of tau to microtubules. Biochemistry. 48: 10047-55. PMID 19769346 DOI: 10.1021/Bi901090M  0.579
2009 Wang Y, Martinez-Vicente M, Krüger U, Kaushik S, Wong E, Mandelkow EM, Cuervo AM, Mandelkow E. Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing. Human Molecular Genetics. 18: 4153-70. PMID 19654187 DOI: 10.1093/Hmg/Ddp367  0.605
2009 Matenia D, Mandelkow EM. The tau of MARK: a polarized view of the cytoskeleton. Trends in Biochemical Sciences. 34: 332-42. PMID 19559622 DOI: 10.1016/j.tibs.2009.03.008  0.401
2009 Schmitt-Ulms G, Matenia D, Drewes G, Mandelkow EM. Interactions of MAP/microtubule affinity regulating kinases with the adaptor complex AP-2 of clathrin-coated vesicles. Cell Motility and the Cytoskeleton. 66: 661-72. PMID 19536824 DOI: 10.1002/Cm.20394  0.625
2009 Marx A, Hoenger A, Mandelkow E. Structures of kinesin motor proteins. Cell Motility and the Cytoskeleton. 66: 958-66. PMID 19530174 DOI: 10.1002/Cm.20392  0.319
2009 Paquet D, Bhat R, Sydow A, Mandelkow EM, Berg S, Hellberg S, Fälting J, Distel M, Köster RW, Schmid B, Haass C. A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation. The Journal of Clinical Investigation. 119: 1382-95. PMID 19363289 DOI: 10.1172/Jci37537  0.433
2009 Mukrasch MD, Bibow S, Korukottu J, Jeganathan S, Biernat J, Griesinger C, Mandelkow E, Zweckstetter M. Structural polymorphism of 441-residue tau at single residue resolution. Plos Biology. 7: e34. PMID 19226187 DOI: 10.1371/Journal.Pbio.1000034  0.555
2009 Bulic B, Pickhardt M, Schmidt B, Mandelkow EM, Waldmann H, Mandelkow E. Development of tau aggregation inhibitors for Alzheimer's disease. Angewandte Chemie (International Ed. in English). 48: 1740-52. PMID 19189357 DOI: 10.1002/Anie.200802621  0.436
2009 Mandelkow E. PL-02-02: Tau and Alzheimer's disease: From structure to transgenic mice and aggregation inhibitors Alzheimer's & Dementia. 5: P92-P92. DOI: 10.1016/J.Jalz.2009.05.242  0.478
2009 Bulic B, Pickhardt M, Schmidt B, Mandelkow E, Waldmann H, Mandelkow E. ChemInform Abstract: Development of Tau Aggregation Inhibitors for Alzheimer′s Disease. Cheminform. 40. DOI: 10.1002/CHIN.200920218  0.384
2009 Bulic B, Pickhardt M, Schmidt B, Mandelkow E, Waldmann H, Mandelkow E. Entwicklung von Inhibitoren der Tau-Aggregation bei Morbus Alzheimer Angewandte Chemie. 121: 1772-1785. DOI: 10.1002/Ange.200802621  0.564
2008 Timm T, Marx A, Panneerselvam S, Mandelkow E, Mandelkow EM. Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein. Bmc Neuroscience. 9: S9. PMID 19090997 DOI: 10.1186/1471-2202-9-S2-S9  0.537
2008 Soragni A, Zambelli B, Mukrasch MD, Biernat J, Jeganathan S, Griesinger C, Ciurli S, Mandelkow E, Zweckstetter M. Structural characterization of binding of Cu(II) to tau protein. Biochemistry. 47: 10841-51. PMID 18803399 DOI: 10.1021/Bi8008856  0.372
2008 Jeganathan S, von Bergen M, Mandelkow EM, Mandelkow E. The natively unfolded character of tau and its aggregation to Alzheimer-like paired helical filaments. Biochemistry. 47: 10526-39. PMID 18783251 DOI: 10.1021/Bi800783D  0.588
2008 Mylonas E, Hascher A, Bernadó P, Blackledge M, Mandelkow E, Svergun DI. Domain conformation of tau protein studied by solution small-angle X-ray scattering. Biochemistry. 47: 10345-53. PMID 18771286 DOI: 10.1021/Bi800900D  0.471
2008 Jeganathan S, Hascher A, Chinnathambi S, Biernat J, Mandelkow EM, Mandelkow E. Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation. The Journal of Biological Chemistry. 283: 32066-76. PMID 18725412 DOI: 10.1074/Jbc.M805300200  0.551
2008 Schneider A, Mandelkow E. Tau-based treatment strategies in neurodegenerative diseases. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 5: 443-57. PMID 18625456 DOI: 10.1016/J.Nurt.2008.05.006  0.625
2008 Timm T, Balusamy K, Li X, Biernat J, Mandelkow E, Mandelkow EM. Glycogen synthase kinase (GSK) 3beta directly phosphorylates Serine 212 in the regulatory loop and inhibits microtubule affinity-regulating kinase (MARK) 2. The Journal of Biological Chemistry. 283: 18873-82. PMID 18424437 DOI: 10.1074/Jbc.M706596200  0.452
2008 Andronesi OC, von Bergen M, Biernat J, Seidel K, Griesinger C, Mandelkow E, Baldus M. Characterization of Alzheimer's-like paired helical filaments from the core domain of tau protein using solid-state NMR spectroscopy. Journal of the American Chemical Society. 130: 5922-8. PMID 18386894 DOI: 10.1021/Ja7100517  0.486
2008 Johne C, Matenia D, Li XY, Timm T, Balusamy K, Mandelkow EM. Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton. Molecular Biology of the Cell. 19: 1391-403. PMID 18216281 DOI: 10.1091/mbc.E07-07-0730  0.313
2008 Marx A, Müller J, Mandelkow EM, Woehlke G, Bouchet-Marquis C, Hoenger A, Mandelkow E. X-ray structure and microtubule interaction of the motor domain of Neurospora crassa NcKin3, a kinesin with unusual processivity. Biochemistry. 47: 1848-61. PMID 18205396 DOI: 10.1021/Bi701483H  0.344
2008 Mocanu MM, Nissen A, Eckermann K, Khlistunova I, Biernat J, Drexler D, Petrova O, Schönig K, Bujard H, Mandelkow E, Zhou L, Rune G, Mandelkow EM. The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 737-48. PMID 18199773 DOI: 10.1523/Jneurosci.2824-07.2008  0.577
2008 Narlawar R, Pickhardt M, Leuchtenberger S, Baumann K, Krause S, Dyrks T, Weggen S, Mandelkow E, Schmidt B. Curcumin-derived pyrazoles and isoxazoles: Swiss army knives or blunt tools for Alzheimer's disease? Chemmedchem. 3: 165-72. PMID 17943713 DOI: 10.1002/Cmdc.200700218  0.486
2008 Mandelkow E, Konzack S, Thies E, Marx A, Mandelkow E. O1-06-05: Swimming against the tide: Mechanisms of Tau distribution in neurons Alzheimer's & Dementia. 4: T121-T121. DOI: 10.1016/J.Jalz.2008.05.260  0.491
2008 Pickhardt M, Bulic B, Larbig G, Coksezen A, Biernat J, Khlistunova I, Mandelkow E, Schmidt B, Waldmann H, Meyer B, Mandelkow E. P2-138: Prevention of tau aggregation in vitro and in cells by low molecular weight compounds derived from phenylthiazolyl-hydrazide or rhodanine core structures Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.1211  0.412
2008 Wang Y, Biernat J, Pickhardt M, Mandelkow E, Mandelkow E. P2-126: Stepwise proteolysis liberates tau fragments that nucleate the aggregation of tau and tau-dependent toxicity in a neuronal cell model Alzheimer's & Dementia. 4: T408-T408. DOI: 10.1016/J.Jalz.2008.05.1200  0.566
2007 Khlistunova I, Pickhardt M, Biernat J, Wang Y, Mandelkow EM, Mandelkow E. Inhibition of tau aggregation in cell models of tauopathy. Current Alzheimer Research. 4: 544-6. PMID 18220518 DOI: 10.2174/156720507783018307  0.56
2007 Bulic B, Pickhardt M, Khlistunova I, Biernat J, Mandelkow EM, Mandelkow E, Waldmann H. Rhodanine-based tau aggregation inhibitors in cell models of tauopathy. Angewandte Chemie (International Ed. in English). 46: 9215-9. PMID 17985339 DOI: 10.1002/Anie.200704051  0.593
2007 Pickhardt M, Biernat J, Khlistunova I, Wang YP, Gazova Z, Mandelkow EM, Mandelkow E. N-phenylamine derivatives as aggregation inhibitors in cell models of tauopathy. Current Alzheimer Research. 4: 397-402. PMID 17908042 DOI: 10.2174/156720507781788765  0.491
2007 Konzack S, Thies E, Marx A, Mandelkow EM, Mandelkow E. Swimming against the tide: mobility of the microtubule-associated protein tau in neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 9916-27. PMID 17855606 DOI: 10.1523/Jneurosci.0927-07.2007  0.515
2007 Eckermann K, Mocanu MM, Khlistunova I, Biernat J, Nissen A, Hofmann A, Schönig K, Bujard H, Haemisch A, Mandelkow E, Zhou L, Rune G, Mandelkow EM. The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy. The Journal of Biological Chemistry. 282: 31755-65. PMID 17716969 DOI: 10.1074/Jbc.M705282200  0.587
2007 Pickhardt M, Larbig G, Khlistunova I, Coksezen A, Meyer B, Mandelkow EM, Schmidt B, Mandelkow E. Phenylthiazolyl-hydrazide and its derivatives are potent inhibitors of tau aggregation and toxicity in vitro and in cells. Biochemistry. 46: 10016-23. PMID 17685560 DOI: 10.1021/Bi700878G  0.5
2007 Larbig G, Pickhardt M, Lloyd DG, Schmidt B, Mandelkow E. Screening for inhibitors of tau protein aggregation into Alzheimer paired helical filaments: a ligand based approach results in successful scaffold hopping. Current Alzheimer Research. 4: 315-23. PMID 17627489 DOI: 10.2174/156720507781077250  0.463
2007 Wang YP, Biernat J, Pickhardt M, Mandelkow E, Mandelkow EM. Stepwise proteolysis liberates tau fragments that nucleate the Alzheimer-like aggregation of full-length tau in a neuronal cell model. Proceedings of the National Academy of Sciences of the United States of America. 104: 10252-7. PMID 17535890 DOI: 10.1073/Pnas.0703676104  0.601
2007 Mandelkow E, von Bergen M, Biernat J, Mandelkow EM. Structural principles of tau and the paired helical filaments of Alzheimer's disease. Brain Pathology (Zurich, Switzerland). 17: 83-90. PMID 17493042 DOI: 10.1111/J.1750-3639.2007.00053.X  0.564
2007 Goldsbury C, Thies E, Konzack S, Mandelkow EM. Quantification of amyloid precursor protein and tau for the study of axonal traffic pathways. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 3357-63. PMID 17392450 DOI: 10.1523/JNEUROSCI.5024-06.2007  0.339
2007 Mukrasch MD, Markwick P, Biernat J, Bergen Mv, Bernadó P, Griesinger C, Mandelkow E, Zweckstetter M, Blackledge M. Highly populated turn conformations in natively unfolded tau protein identified from residual dipolar couplings and molecular simulation. Journal of the American Chemical Society. 129: 5235-43. PMID 17385861 DOI: 10.1021/Ja0690159  0.403
2007 Thies E, Mandelkow EM. Missorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2/Par-1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 2896-907. PMID 17360912 DOI: 10.1523/JNEUROSCI.4674-06.2007  0.424
2007 Steinhilb ML, Dias-Santagata D, Mulkearns EE, Shulman JM, Biernat J, Mandelkow EM, Feany MB. S/P and T/P phosphorylation is critical for tau neurotoxicity in Drosophila. Journal of Neuroscience Research. 85: 1271-8. PMID 17335084 DOI: 10.1002/Jnr.21232  0.39
2007 Mukrasch MD, von Bergen M, Biernat J, Fischer D, Griesinger C, Mandelkow E, Zweckstetter M. The "jaws" of the tau-microtubule interaction. The Journal of Biological Chemistry. 282: 12230-9. PMID 17307736 DOI: 10.1074/Jbc.M607159200  0.557
2007 Fischer D, Mukrasch MD, von Bergen M, Klos-Witkowska A, Biernat J, Griesinger C, Mandelkow E, Zweckstetter M. Structural and microtubule binding properties of tau mutants of frontotemporal dementias. Biochemistry. 46: 2574-82. PMID 17297915 DOI: 10.1021/Bi061318S  0.489
2007 Redecke L, von Bergen M, Clos J, Konarev PV, Svergun DI, Fittschen UE, Broekaert JA, Bruns O, Georgieva D, Mandelkow E, Genov N, Betzel C. Structural characterization of beta-sheeted oligomers formed on the pathway of oxidative prion protein aggregation in vitro. Journal of Structural Biology. 157: 308-20. PMID 17023178 DOI: 10.1016/J.Jsb.2006.06.013  0.384
2006 Timm T, Matenia D, Li XY, Griesshaber B, Mandelkow EM. Signaling from MARK to tau: regulation, cytoskeletal crosstalk, and pathological phosphorylation. Neuro-Degenerative Diseases. 3: 207-17. PMID 17047359 DOI: 10.1159/000095258  0.456
2006 von Bergen M, Barghorn S, Jeganathan S, Mandelkow EM, Mandelkow E. Spectroscopic approaches to the conformation of tau protein in solution and in paired helical filaments. Neuro-Degenerative Diseases. 3: 197-206. PMID 17047358 DOI: 10.1159/000095257  0.541
2006 Marx A, Nugoor C, Müller J, Panneerselvam S, Timm T, Bilang M, Mylonas E, Svergun DI, Mandelkow EM, Mandelkow E. Structural variations in the catalytic and ubiquitin-associated domains of microtubule-associated protein/microtubule affinity regulating kinase (MARK) 1 and MARK2. The Journal of Biological Chemistry. 281: 27586-99. PMID 16803889 DOI: 10.1074/Jbc.M604865200  0.386
2006 Goldsbury C, Mocanu MM, Thies E, Kaether C, Haass C, Keller P, Biernat J, Mandelkow E, Mandelkow EM. Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides. Traffic (Copenhagen, Denmark). 7: 873-88. PMID 16734669 DOI: 10.1111/J.1600-0854.2006.00434.X  0.433
2006 von Bergen M, Barghorn S, Müller SA, Pickhardt M, Biernat J, Mandelkow EM, Davies P, Aebi U, Mandelkow E. The core of tau-paired helical filaments studied by scanning transmission electron microscopy and limited proteolysis. Biochemistry. 45: 6446-57. PMID 16700555 DOI: 10.1021/Bi052530J  0.556
2006 Jeganathan S, von Bergen M, Brutlach H, Steinhoff HJ, Mandelkow E. Global hairpin folding of tau in solution. Biochemistry. 45: 2283-93. PMID 16475817 DOI: 10.1021/Bi0521543  0.539
2006 Panneerselvam S, Marx A, Mandelkow EM, Mandelkow E. Structure of the catalytic and ubiquitin-associated domains of the protein kinase MARK/Par-1. Structure (London, England : 1993). 14: 173-83. PMID 16472737 DOI: 10.1016/J.Str.2005.09.022  0.402
2006 Marx A, Müller J, Mandelkow EM, Hoenger A, Mandelkow E. Interaction of kinesin motors, microtubules, and MAPs. Journal of Muscle Research and Cell Motility. 27: 125-37. PMID 16362723 DOI: 10.1007/S10974-005-9051-4  0.364
2006 Khlistunova I, Biernat J, Wang Y, Pickhardt M, von Bergen M, Gazova Z, Mandelkow E, Mandelkow EM. Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs. The Journal of Biological Chemistry. 281: 1205-14. PMID 16246844 DOI: 10.1074/Jbc.M507753200  0.506
2006 Wang Y, Khlistunova I, Biernat J, Pickhardt M, Bergen Mv, Mandelkow E, Mandelkow EM. P2-047: Inducible cell model of tauopathy expressing full-length tau Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.884  0.391
2006 Jeganathan S, Bergen Mv, Mandelkow E. P3-316: Fret analysis of the conformation of tau in solution Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.1586  0.364
2006 Pickhardt M, Gazova Z, von Bergen M, Biernat J, Khlistunova I, Wang Y, Hascher A, Mandelkow E, Mandelkow E. P3-303: Inhibition of tau aggregation and disaggregation of PHFs by low MW compounds in vitro and in cells Alzheimer's & Dementia. 2: S464-S464. DOI: 10.1016/J.Jalz.2006.05.1573  0.439
2005 Matenia D, Griesshaber B, Li XY, Thiessen A, Johne C, Jiao J, Mandelkow E, Mandelkow EM. PAK5 kinase is an inhibitor of MARK/Par-1, which leads to stable microtubules and dynamic actin. Molecular Biology of the Cell. 16: 4410-22. PMID 16014608 DOI: 10.1091/Mbc.E05-01-0081  0.464
2005 von Bergen M, Li L, Mandelkow E. Intrinsic fluorescent detection of tau conformation and aggregation. Methods in Molecular Biology (Clifton, N.J.). 299: 175-84. PMID 15980601 DOI: 10.1385/1-59259-874-9:175  0.473
2005 Barghorn S, Biernat J, Mandelkow E. Purification of recombinant tau protein and preparation of Alzheimer-paired helical filaments in vitro. Methods in Molecular Biology (Clifton, N.J.). 299: 35-51. PMID 15980594 DOI: 10.1385/1-59259-874-9:035  0.615
2005 Pickhardt M, von Bergen M, Gazova Z, Hascher A, Biernat J, Mandelkow EM, Mandelkow E. Screening for inhibitors of tau polymerization. Current Alzheimer Research. 2: 219-26. PMID 15974921 DOI: 10.2174/1567205053585891  0.569
2005 Mukrasch MD, Biernat J, von Bergen M, Griesinger C, Mandelkow E, Zweckstetter M. Sites of tau important for aggregation populate {beta}-structure and bind to microtubules and polyanions. The Journal of Biological Chemistry. 280: 24978-86. PMID 15855160 DOI: 10.1074/Jbc.M501565200  0.558
2005 von Bergen M, Barghorn S, Biernat J, Mandelkow EM, Mandelkow E. Tau aggregation is driven by a transition from random coil to beta sheet structure. Biochimica Et Biophysica Acta. 1739: 158-66. PMID 15615635 DOI: 10.1016/J.Bbadis.2004.09.010  0.482
2005 Pickhardt M, Gazova Z, von Bergen M, Khlistunova I, Wang Y, Hascher A, Mandelkow EM, Biernat J, Mandelkow E. Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells. The Journal of Biological Chemistry. 280: 3628-35. PMID 15525637 DOI: 10.1074/Jbc.M410984200  0.575
2004 Schneider A, Araújo GW, Trajkovic K, Herrmann MM, Merkler D, Mandelkow EM, Weissert R, Simons M. Hyperphosphorylation and aggregation of tau in experimental autoimmune encephalomyelitis. The Journal of Biological Chemistry. 279: 55833-9. PMID 15494405 DOI: 10.1074/Jbc.M409954200  0.415
2004 Mandelkow EM, Thies E, Trinczek B, Biernat J, Mandelkow E. MARK/PAR1 kinase is a regulator of microtubule-dependent transport in axons. The Journal of Cell Biology. 167: 99-110. PMID 15466480 DOI: 10.1083/jcb.200401085  0.314
2004 Santarella RA, Skiniotis G, Goldie KN, Tittmann P, Gross H, Mandelkow EM, Mandelkow E, Hoenger A. Surface-decoration of microtubules by human tau. Journal of Molecular Biology. 339: 539-53. PMID 15147841 DOI: 10.1016/J.Jmb.2004.04.008  0.588
2004 Skiniotis G, Cochran JC, Müller J, Mandelkow E, Gilbert SP, Hoenger A. Modulation of kinesin binding by the C-termini of tubulin. The Embo Journal. 23: 989-99. PMID 14976555 DOI: 10.1038/Sj.Emboj.7600118  0.327
2004 Barghorn S, Davies P, Mandelkow E. Tau paired helical filaments from Alzheimer's disease brain and assembled in vitro are based on beta-structure in the core domain. Biochemistry. 43: 1694-703. PMID 14769047 DOI: 10.1021/Bi0357006  0.474
2004 Pickhardt M, Gazova Z, von Bergen M, Wang Y, Khlistounova I, Hascher A, Biernat J, Mandelkow EM, Mandelkow E. P3-257 Search for small molecule inhibitors of tau aggregation into Alzheimer paired helical filaments Neurobiology of Aging. 25: S428. DOI: 10.1016/S0197-4580(04)81407-6  0.498
2004 Bergen Mv, Li L, Mandelkow E. P3-225 Conformation and stability of tau and Alzheimer paired helical filaments probed by tryptophan scanning mutagenesis Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81375-7  0.49
2004 Mandelkow E, von Bergen M, Barghorn S, Li L, Biernat J, Mandelkow e. S3-02-01 Principles of assembly of tau protein into Alzheimer paired helical filaments Neurobiology of Aging. 25: S47. DOI: 10.1016/S0197-4580(04)80157-X  0.567
2003 Mandelkow EM, Stamer K, Vogel R, Thies E, Mandelkow E. Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses. Neurobiology of Aging. 24: 1079-85. PMID 14643379 DOI: 10.1016/J.Neurobiolaging.2003.04.007  0.54
2003 Ganzer S, Arlt S, Schoder V, Buhmann C, Mandelkow EM, Finckh U, Beisiegel U, Naber D, Müller-Thomsen T. CSF-tau, CSF-Abeta1-42, ApoE-genotype and clinical parameters in the diagnosis of Alzheimer's disease: combination of CSF-tau and MMSE yields highest sensitivity and specificity. Journal of Neural Transmission (Vienna, Austria : 1996). 110: 1149-60. PMID 14523627 DOI: 10.1007/s00702-003-0017-7  0.353
2003 Timm T, Li XY, Biernat J, Jiao J, Mandelkow E, Vandekerckhove J, Mandelkow EM. MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1. The Embo Journal. 22: 5090-101. PMID 14517247 DOI: 10.1093/Emboj/Cdg447  0.458
2003 Skiniotis G, Surrey T, Altmann S, Gross H, Song YH, Mandelkow E, Hoenger A. Nucleotide-induced conformations in the neck region of dimeric kinesin. The Embo Journal. 22: 1518-28. PMID 12660159 DOI: 10.1093/Emboj/Cdg164  0.316
2002 Mandelkow E, Mandelkow EM. Kinesin motors and disease. Trends in Cell Biology. 12: 585-91. PMID 12495847 DOI: 10.1016/S0962-8924(02)02400-5  0.318
2002 Barghorn S, Mandelkow E. Toward a unified scheme for the aggregation of tau into Alzheimer paired helical filaments. Biochemistry. 41: 14885-96. PMID 12475237 DOI: 10.1021/Bi026469J  0.511
2002 Biernat J, Wu YZ, Timm T, Zheng-Fischhöfer Q, Mandelkow E, Meijer L, Mandelkow EM. Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity. Molecular Biology of the Cell. 13: 4013-28. PMID 12429843 DOI: 10.1091/Mbc.02-03-0046  0.547
2002 Wendt TG, Volkmann N, Skiniotis G, Goldie KN, Müller J, Mandelkow E, Hoenger A. Microscopic evidence for a minus-end-directed power stroke in the kinesin motor ncd. The Embo Journal. 21: 5969-78. PMID 12426369 DOI: 10.1093/Emboj/Cdf622  0.339
2002 Seitz A, Kojima H, Oiwa K, Mandelkow EM, Song YH, Mandelkow E. Single-molecule investigation of the interference between kinesin, tau and MAP2c. The Embo Journal. 21: 4896-905. PMID 12234929 DOI: 10.1093/Emboj/Cdf503  0.374
2002 Li L, von Bergen M, Mandelkow EM, Mandelkow E. Structure, stability, and aggregation of paired helical filaments from tau protein and FTDP-17 mutants probed by tryptophan scanning mutagenesis. The Journal of Biological Chemistry. 277: 41390-400. PMID 12198126 DOI: 10.1074/Jbc.M206334200  0.523
2002 Stamer K, Vogel R, Thies E, Mandelkow E, Mandelkow EM. Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress. The Journal of Cell Biology. 156: 1051-63. PMID 11901170 DOI: 10.1083/Jcb.200108057  0.523
2002 Augustinack JC, Schneider A, Mandelkow EM, Hyman BT. Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease. Acta Neuropathologica. 103: 26-35. PMID 11837744 DOI: 10.1007/S004010100423  0.607
2001 von Bergen M, Barghorn S, Li L, Marx A, Biernat J, Mandelkow EM, Mandelkow E. Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure. The Journal of Biological Chemistry. 276: 48165-74. PMID 11606569 DOI: 10.1074/Jbc.M105196200  0.536
2001 Vilfan A, Frey E, Schwabl F, Thormählen M, Song YH, Mandelkow E. Dynamics and cooperativity of microtubule decoration by the motor protein kinesin. Journal of Molecular Biology. 312: 1011-26. PMID 11580246 DOI: 10.1006/Jmbi.2001.5020  0.336
2001 Hartmann AM, Rujescu D, Giannakouros T, Nikolakaki E, Goedert M, Mandelkow EM, Gao QS, Andreadis A, Stamm S. Regulation of alternative splicing of human tau exon 10 by phosphorylation of splicing factors. Molecular and Cellular Neurosciences. 18: 80-90. PMID 11461155 DOI: 10.1006/Mcne.2001.1000  0.378
2000 Chin JY, Knowles RB, Schneider A, Drewes G, Mandelkow EM, Hyman BT. Microtubule-affinity regulating kinase (MARK) is tightly associated with neurofibrillary tangles in Alzheimer brain: a fluorescence resonance energy transfer study. Journal of Neuropathology and Experimental Neurology. 59: 966-71. PMID 11089574 DOI: 10.1093/Jnen/59.11.966  0.612
2000 Hoenger A, Doerhoefer M, Woehlke G, Tittmann P, Gross H, Song YH, Mandelkow E. Surface topography of microtubule walls decorated with monomeric and dimeric kinesin constructs. Biological Chemistry. 381: 1001-11. PMID 11076033 DOI: 10.1515/Bc.2000.123  0.32
2000 Seeberger C, Mandelkow E, Meyer B. Conformational preferences of a synthetic 30mer peptide from the interface between the neck and stalk regions of kinesin. Biochemistry. 39: 12558-67. PMID 11027135 DOI: 10.1021/Bi000719J  0.301
2000 Barghorn S, Zheng-Fischhöfer Q, Ackmann M, Biernat J, von Bergen M, Mandelkow EM, Mandelkow E. Structure, microtubule interactions, and paired helical filament aggregation by tau mutants of frontotemporal dementias. Biochemistry. 39: 11714-21. PMID 10995239 DOI: 10.1021/Bi000850R  0.576
2000 Friedhoff P, von Bergen M, Mandelkow EM, Mandelkow E. Structure of tau protein and assembly into paired helical filaments. Biochimica Et Biophysica Acta. 1502: 122-32. PMID 10899437 DOI: 10.1016/S0925-4439(00)00038-7  0.58
2000 Ackmann M, Wiech H, Mandelkow E. Nonsaturable binding indicates clustering of tau on the microtubule surface in a paired helical filament-like conformation. The Journal of Biological Chemistry. 275: 30335-43. PMID 10869348 DOI: 10.1074/Jbc.M002590200  0.611
2000 von Bergen M, Friedhoff P, Biernat J, Heberle J, Mandelkow EM, Mandelkow E. Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure. Proceedings of the National Academy of Sciences of the United States of America. 97: 5129-34. PMID 10805776 DOI: 10.1073/Pnas.97.10.5129  0.521
2000 Hoenger A, Thormählen M, Diaz-Avalos R, Doerhoefer M, Goldie KN, Müller J, Mandelkow E. A new look at the microtubule binding patterns of dimeric kinesins. Journal of Molecular Biology. 297: 1087-103. PMID 10764575 DOI: 10.1006/Jmbi.2000.3627  0.364
2000 Mandelkow E, von Bergen M, Biernat J, Barghorn S, Schneider A, Mandelkow E. Pathway of tau aggregation into Alzheimer paired helical filaments Biochemical Society Transactions. 28: A108-A108. DOI: 10.1042/Bst028A108B  0.578
2000 Mandelkow E, von Bergen M, Schneider A, Biernat J, Mandelkow E. Pathway of tau aggregation into Alzheimer paired helical filaments Neurobiology of Aging. 21: 210. DOI: 10.1016/S0197-4580(00)83275-3  0.578
2000 Barghorn S, von Bergen M, Ackmann M, Zheng-Fishhoefer Q, Wiech H, Mandelkow E. Effects of FTDP-17 mutations of tau on tau functions Neurobiology of Aging. 21: 15. DOI: 10.1016/S0197-4580(00)82746-3  0.465
2000 Vogel R, Biernat J, Mandelkow E. Generation of adenovirus vectors for cell models of Alzheimer's disease Neurobiology of Aging. 21: 84-85. DOI: 10.1016/S0197-4580(00)82604-4  0.356
2000 Mandelkow E, Ebneth A, Stamer K, Aventis RG, Drewes G, Biernat J, Trinczek B, Mandelkow E. Tau protein and Alzheimer's disease: Phosphorylation and role in intracellular trafficking Neurobiology of Aging. 21: 73. DOI: 10.1016/S0197-4580(00)82548-8  0.541
2000 von Bergen M, Friedhoff P, Biernat J, Mandelkow E, Mandelkow E. Rapid aggregation of tau protein into Alzheimer-like paired helical filaments reveals a nucleation-elongation mechanism Neurobiology of Aging. 21: 197. DOI: 10.1016/S0197-4580(00)82231-9  0.597
1999 Mandelkow E. Alzheimer's disease. The tangled tale of tau. Nature. 402: 588-9. PMID 10604460 DOI: 10.1038/45095  0.418
1999 Ebneth A, Drewes G, Mandelkow EM, Mandelkow E. Phosphorylation of MAP2c and MAP4 by MARK kinases leads to the destabilization of microtubules in cells. Cell Motility and the Cytoskeleton. 44: 209-24. PMID 10542369 DOI: 10.1002/(Sici)1097-0169(199911)44:3<209::Aid-Cm6>3.0.Co;2-4  0.442
1999 Müller J, Marx A, Sack S, Song YH, Mandelkow E. The structure of the nucleotide-binding site of kinesin. Biological Chemistry. 380: 981-92. PMID 10494851 DOI: 10.1515/Bc.1999.122  0.351
1999 Godemann R, Biernat J, Mandelkow E, Mandelkow EM. Phosphorylation of tau protein by recombinant GSK-3beta: pronounced phosphorylation at select Ser/Thr-Pro motifs but no phosphorylation at Ser262 in the repeat domain. Febs Letters. 454: 157-64. PMID 10413115 DOI: 10.1016/S0014-5793(99)00741-3  0.429
1999 Haass C, Mandelkow E. Proteolysis by presenilins and the renaissance of tau. Trends in Cell Biology. 9: 241-4. PMID 10408925 DOI: 10.1016/S0962-8924(99)01576-7  0.489
1999 Trinczek B, Ebneth A, Mandelkow EM, Mandelkow E. Tau regulates the attachment/detachment but not the speed of motors in microtubule-dependent transport of single vesicles and organelles. Journal of Cell Science. 112: 2355-67. PMID 10381391  0.366
1999 Kampers T, Pangalos M, Geerts H, Wiech H, Mandelkow E. Assembly of paired helical filaments from mouse tau: implications for the neurofibrillary pathology in transgenic mouse models for Alzheimer's disease. Febs Letters. 451: 39-44. PMID 10356980 DOI: 10.1016/S0014-5793(99)00522-0  0.603
1999 Sack S, Kull FJ, Mandelkow E. Motor proteins of the kinesin family. Structures, variations, and nucleotide binding sites. European Journal of Biochemistry / Febs. 262: 1-11. PMID 10231357 DOI: 10.1046/J.1432-1327.1999.00341.X  0.338
1999 Schneider A, Biernat J, von Bergen M, Mandelkow E, Mandelkow EM. Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments. Biochemistry. 38: 3549-58. PMID 10090741 DOI: 10.1021/Bi981874P  0.597
1999 Biernat J, Mandelkow EM. The development of cell processes induced by tau protein requires phosphorylation of serine 262 and 356 in the repeat domain and is inhibited by phosphorylation in the proline-rich domains. Molecular Biology of the Cell. 10: 727-40. PMID 10069814  0.428
1999 Mandelkow E, Hoenger A. Structures of kinesin and kinesin-microtubule interactions. Current Opinion in Cell Biology. 11: 34-44. PMID 10047529 DOI: 10.1016/S0955-0674(99)80005-2  0.352
1998 Friedhoff P, von Bergen M, Mandelkow EM, Davies P, Mandelkow E. A nucleated assembly mechanism of Alzheimer paired helical filaments. Proceedings of the National Academy of Sciences of the United States of America. 95: 15712-7. PMID 9861035 DOI: 10.1073/Pnas.95.26.15712  0.609
1998 Mandelkow EM, Mandelkow E. Tau in Alzheimer's disease. Trends in Cell Biology. 8: 425-7. PMID 9854307 DOI: 10.1016/S0962-8924(98)01368-3  0.611
1998 Mandelkow E, Johnson KA. The structural and mechanochemical cycle of kinesin. Trends in Biochemical Sciences. 23: 429-33. PMID 9852761 DOI: 10.1016/S0968-0004(98)01278-X  0.369
1998 Ebneth A, Godemann R, Stamer K, Illenberger S, Trinczek B, Mandelkow E. Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease. The Journal of Cell Biology. 143: 777-94. PMID 9813097 DOI: 10.1083/Jcb.143.3.777  0.514
1998 Marx A, Thormählen M, Müller J, Sack S, Mandelkow EM, Mandelkow E. Conformations of kinesin: solution vs. crystal structures and interactions with microtubules. European Biophysics Journal : Ebj. 27: 455-65. PMID 9760727 DOI: 10.1007/S002490050156  0.344
1998 Thormählen M, Marx A, Sack S, Mandelkow E. The coiled-coil helix in the neck of kinesin. Journal of Structural Biology. 122: 30-41. PMID 9724604 DOI: 10.1006/Jsbi.1998.3986  0.326
1998 Preuss U, Mandelkow EM. Mitotic phosphorylation of tau protein in neuronal cell lines resembles phosphorylation in Alzheimer's disease. European Journal of Cell Biology. 76: 176-84. PMID 9716264 DOI: 10.1016/S0171-9335(98)80032-0  0.466
1998 Friedhoff P, Schneider A, Mandelkow EM, Mandelkow E. Rapid assembly of Alzheimer-like paired helical filaments from microtubule-associated protein tau monitored by fluorescence in solution. Biochemistry. 37: 10223-30. PMID 9665729 DOI: 10.1021/Bi980537D  0.588
1998 Illenberger S, Zheng-Fischhöfer Q, Preuss U, Stamer K, Baumann K, Trinczek B, Biernat J, Godemann R, Mandelkow EM, Mandelkow E. The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease. Molecular Biology of the Cell. 9: 1495-512. PMID 9614189 DOI: 10.1091/Mbc.9.6.1495  0.582
1998 Hoenger A, Sack S, Thormählen M, Marx A, Müller J, Gross H, Mandelkow E. Image reconstructions of microtubules decorated with monomeric and dimeric kinesins: comparison with x-ray structure and implications for motility. The Journal of Cell Biology. 141: 419-30. PMID 9548720 DOI: 10.1083/Jcb.141.2.419  0.382
1998 Zheng-Fischhöfer Q, Biernat J, Mandelkow EM, Illenberger S, Godemann R, Mandelkow E. Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation. European Journal of Biochemistry / Febs. 252: 542-52. PMID 9546672 DOI: 10.1046/J.1432-1327.1998.2520542.X  0.483
1998 Thormählen M, Marx A, Müller SA, Song Y, Mandelkow EM, Aebi U, Mandelkow E. Interaction of monomeric and dimeric kinesin with microtubules. Journal of Molecular Biology. 275: 795-809. PMID 9480770 DOI: 10.1006/Jmbi.1997.1503  0.361
1997 Kozielski F, Sack S, Marx A, Thormählen M, Schönbrunn E, Biou V, Thompson A, Mandelkow EM, Mandelkow E. The crystal structure of dimeric kinesin and implications for microtubule-dependent motility. Cell. 91: 985-94. PMID 9428521 DOI: 10.1016/S0092-8674(00)80489-4  0.361
1997 Felgner H, Frank R, Biernat J, Mandelkow EM, Mandelkow E, Ludin B, Matus A, Schliwa M. Domains of neuronal microtubule-associated proteins and flexural rigidity of microtubules. The Journal of Cell Biology. 138: 1067-75. PMID 9281584 DOI: 10.1083/Jcb.138.5.1067  0.487
1997 Drewes G, Ebneth A, Preuss U, Mandelkow EM, Mandelkow E. MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. Cell. 89: 297-308. PMID 9108484 DOI: 10.1016/S0092-8674(00)80208-1  0.469
1997 Preuss U, Biernat J, Mandelkow EM, Mandelkow E. The 'jaws' model of tau-microtubule interaction examined in CHO cells. Journal of Cell Science. 110: 789-800. PMID 9099953  0.432
1996 Kampers T, Friedhoff P, Biernat J, Mandelkow EM, Mandelkow E. RNA stimulates aggregation of microtubule-associated protein tau into Alzheimer-like paired helical filaments. Febs Letters. 399: 344-9. PMID 8985176 DOI: 10.1016/S0014-5793(96)01386-5  0.556
1996 Illenberger S, Drewes G, Trinczek B, Biernat J, Meyer HE, Olmsted JB, Mandelkow EM, Mandelkow E. Phosphorylation of microtubule-associated proteins MAP2 and MAP4 by the protein kinase p110mark. Phosphorylation sites and regulation of microtubule dynamics. The Journal of Biological Chemistry. 271: 10834-43. PMID 8631898 DOI: 10.1074/Jbc.271.18.10834  0.454
1996 Mandelkow EM, Schweers O, Drewes G, Biernat J, Gustke N, Trinczek B, Mandelkow E. Structure, microtubule interactions, and phosphorylation of tau protein. Annals of the New York Academy of Sciences. 777: 96-106. PMID 8624133 DOI: 10.1111/J.1749-6632.1996.Tb34407.X  0.552
1996 Drewes G, Trinczek B, Illenberger S, Biernat J, Mandelkow E-, Mandelkow E. 758 Microtubule Affinity Regulating Kinase (MARK), a potential regulator of the microtubule cytoskeleton Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80760-3  0.403
1996 Mandelkow E, Schweers O, Biernat J, Mandelkow E-. 756 Structure of tau and assembly into paired helical filaments Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80758-5  0.513
1996 von Bergen M, Friedhoff P, Gross U, Mandelkow E. 514 Quantification of in vivo phosphorylation sites of tau protein Neurobiology of Aging. 17: S128. DOI: 10.1016/S0197-4580(96)80516-1  0.376
1995 Mandelkow E, Song YH, Mandelkow EM. The microtubule lattice--dynamic instability of concepts. Trends in Cell Biology. 5: 262-6. PMID 14732102 DOI: 10.1016/S0962-8924(00)89029-7  0.343
1995 Trinczek B, Biernat J, Baumann K, Mandelkow EM, Mandelkow E. Domains of tau protein, differential phosphorylation, and dynamic instability of microtubules. Molecular Biology of the Cell. 6: 1887-902. PMID 8590813 DOI: 10.1091/Mbc.6.12.1887  0.541
1995 Preuss U, Döring F, Illenberger S, Mandelkow EM. Cell cycle-dependent phosphorylation and microtubule binding of tau protein stably transfected into Chinese hamster ovary cells. Molecular Biology of the Cell. 6: 1397-410. PMID 8573794  0.527
1995 Song YH, Mandelkow E. The anatomy of flagellar microtubules: polarity, seam, junctions, and lattice. The Journal of Cell Biology. 128: 81-94. PMID 7822425 DOI: 10.1083/Jcb.128.1.81  0.364
1995 Mandelkow E, Mandelkow EM. Microtubules and microtubule-associated proteins. Current Opinion in Cell Biology. 7: 72-81. PMID 7755992 DOI: 10.1016/0955-0674(95)80047-6  0.454
1995 Drewes G, Trinczek B, Illenberger S, Biernat J, Schmitt-Ulms G, Meyer HE, Mandelkow EM, Mandelkow E. Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262. The Journal of Biological Chemistry. 270: 7679-88. PMID 7706316 DOI: 10.1074/jbc.270.13.7679  0.714
1995 Schweers O, Mandelkow EM, Biernat J, Mandelkow E. Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments. Proceedings of the National Academy of Sciences of the United States of America. 92: 8463-7. PMID 7667312 DOI: 10.1073/Pnas.92.18.8463  0.608
1995 Mandelkow EM, Biernat J, Drewes G, Gustke N, Trinczek B, Mandelkow E. Tau domains, phosphorylation, and interactions with microtubules. Neurobiology of Aging. 16: 355-62; discussion 3. PMID 7566345 DOI: 10.1016/0197-4580(95)00025-A  0.539
1995 Mandelkow E, Song YH, Schweers O, Marx A, Mandelkow EM. On the structure of microtubules, tau, and paired helical filaments. Neurobiology of Aging. 16: 347-54. PMID 7566344 DOI: 10.1016/0197-4580(95)00026-B  0.525
1994 Marx A, Mandelkow E. A model of microtubule oscillations. European Biophysics Journal : Ebj. 22: 405-21. PMID 8149923 DOI: 10.1007/Bf00180162  0.351
1994 Gustke N, Trinczek B, Biernat J, Mandelkow EM, Mandelkow E. Domains of tau protein and interactions with microtubules. Biochemistry. 33: 9511-22. PMID 8068626 DOI: 10.1021/Bi00198A017  0.506
1994 Song YH, Mandelkow E. Paracrystalline structure of the stalk domain of the microtubule motor protein kinesin. Journal of Structural Biology. 112: 93-102. PMID 8060732 DOI: 10.1006/Jsbi.1994.1010  0.364
1994 Schweers O, Schönbrunn-Hanebeck E, Marx A, Mandelkow E. Structural studies of tau protein and Alzheimer paired helical filaments show no evidence for beta-structure. The Journal of Biological Chemistry. 269: 24290-7. PMID 7929085  0.401
1994 Mandelkow EM, Mandelkow E. Tau protein and Alzheimer's disease. Neurobiology of Aging. 15: S85-6. PMID 7700470 DOI: 10.1016/0197-4580(94)90178-3  0.534
1993 Trinczek B, Marx A, Mandelkow EM, Murphy DB, Mandelkow E. Dynamics of microtubules from erythrocyte marginal bands. Molecular Biology of the Cell. 4: 323-35. PMID 8485321 DOI: 10.1091/Mbc.4.3.323  0.396
1993 Song YH, Mandelkow E. Recombinant kinesin motor domain binds to beta-tubulin and decorates microtubules with a B surface lattice. Proceedings of the National Academy of Sciences of the United States of America. 90: 1671-5. PMID 8446580 DOI: 10.1073/Pnas.90.5.1671  0.378
1993 Biernat J, Gustke N, Drewes G, Mandelkow EM, Mandelkow E. Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding. Neuron. 11: 153-63. PMID 8393323  0.377
1993 Drewes G, Mandelkow EM, Baumann K, Goris J, Merlevede W, Mandelkow E. Dephosphorylation of tau protein and Alzheimer paired helical filaments by calcineurin and phosphatase-2A. Febs Letters. 336: 425-32. PMID 8282105 DOI: 10.1016/0014-5793(93)80850-T  0.497
1993 Baumann K, Mandelkow EM, Biernat J, Piwnica-Worms H, Mandelkow E. Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5. Febs Letters. 336: 417-24. PMID 8282104 DOI: 10.1016/0014-5793(93)80849-P  0.449
1993 Mandelkow EM, Mandelkow E. Tau as a marker for Alzheimer's disease. Trends in Biochemical Sciences. 18: 480-3. PMID 8108862 DOI: 10.1016/0968-0004(93)90011-B  0.462
1993 Mandelkow EM, Biernat J, Drewes G, Steiner B, Lichtenberg-Kraag B, Wille H, Gustke N, Mandelkow E. Microtubule-associated protein tau, paired helical filaments, and phosphorylation. Annals of the New York Academy of Sciences. 695: 209-16. PMID 7694533 DOI: 10.1111/J.1749-6632.1993.Tb23054.X  0.576
1992 Gustke N, Steiner B, Mandelkow EM, Biernat J, Meyer HE, Goedert M, Mandelkow E. The Alzheimer-like phosphorylation of tau protein reduces microtubule binding and involves Ser-Pro and Thr-Pro motifs. Febs Letters. 307: 199-205. PMID 1644173 DOI: 10.1016/0014-5793(92)80767-B  0.543
1992 Wille H, Drewes G, Biernat J, Mandelkow EM, Mandelkow E. Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro. The Journal of Cell Biology. 118: 573-84. PMID 1639844 DOI: 10.1083/Jcb.118.3.573  0.576
1992 Biernat J, Mandelkow EM, Schröter C, Lichtenberg-Kraag B, Steiner B, Berling B, Meyer H, Mercken M, Vandermeeren A, Goedert M. The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region. The Embo Journal. 11: 1593-7. PMID 1563356 DOI: 10.1002/J.1460-2075.1992.Tb05204.X  0.462
1992 Kamimura S, Mandelkow E. Tubulin protofilaments and kinesin-dependent motility. The Journal of Cell Biology. 118: 865-75. PMID 1500429 DOI: 10.1083/Jcb.118.4.865  0.378
1992 Lichtenberg-Kraag B, Mandelkow EM, Biernat J, Steiner B, Schröter C, Gustke N, Meyer HE, Mandelkow E. Phosphorylation-dependent epitopes of neurofilament antibodies on tau protein and relationship with Alzheimer tau. Proceedings of the National Academy of Sciences of the United States of America. 89: 5384-8. PMID 1376918 DOI: 10.1073/Pnas.89.12.5384  0.518
1992 Drewes G, Lichtenberg-Kraag B, Döring F, Mandelkow EM, Biernat J, Goris J, Dorée M, Mandelkow E. Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state. The Embo Journal. 11: 2131-8. PMID 1376245 DOI: 10.1002/J.1460-2075.1992.Tb05272.X  0.53
1992 Wille H, Mandelkow EM, Dingus J, Vallee RB, Binder LI, Mandelkow E. Domain structure and antiparallel dimers of microtubule-associated protein 2 (MAP2). Journal of Structural Biology. 108: 49-61. PMID 1373291 DOI: 10.1016/1047-8477(92)90006-V  0.376
1992 Mandelkow EM, Drewes G, Biernat J, Gustke N, Van Lint J, Vandenheede JR, Mandelkow E. Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau. Febs Letters. 314: 315-21. PMID 1334849 DOI: 10.1016/0014-5793(92)81496-9  0.489
1992 Mandelkow E-, Lichtenberg-Kraag B, Steiner B, Biernat J, Gustke N, Wille H, Drewes G, Meyer H, Mandelkow E. The Alzheimer-like state of tau protein: A study of isoforms, phosphorylation sites, antibody epitopes, and protein kinases Neurobiology of Aging. 13. DOI: 10.1016/0197-4580(92)90336-V  0.473
1991 Song YH, Heins S, Mandelkow E, Mandelkow EM. Aluminum fluoride, microtubule stability, and kinesin rigor. Journal of Cell Science. Supplement. 14: 147-50. PMID 1832168 DOI: 10.1242/Jcs.1991.Supplement_14.30  0.36
1991 Heins S, Song YH, Wille H, Mandelkow E, Mandelkow EM. Effect of MAP2, MAP2c, and tau on kinesin-dependent microtubule motility. Journal of Cell Science. Supplement. 14: 121-4. PMID 1832164 DOI: 10.1242/Jcs.1991.Supplement_14.24  0.41
1990 Marx A, Jagla A, Mandelkow E. Microtubule assembly and oscillations induced by flash photolysis of caged-GTP. European Biophysics Journal : Ebj. 19: 1-9. PMID 2269211 DOI: 10.1007/Bf00223567  0.344
1990 Lichtenberg-Kraag B, Mandelkow EM. Isoforms of tau protein from mammalian brain and avian erythrocytes: structure, self-assembly, and elasticity. Journal of Structural Biology. 105: 46-53. PMID 2129217  0.432
1990 Steiner B, Mandelkow EM, Biernat J, Gustke N, Meyer HE, Schmidt B, Mieskes G, Söling HD, Drechsel D, Kirschner MW. Phosphorylation of microtubule-associated protein tau: identification of the site for Ca2(+)-calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles. The Embo Journal. 9: 3539-44. PMID 2120043 DOI: 10.1002/J.1460-2075.1990.Tb07563.X  0.451
1989 Mandelkow E, Mandelkow EM, Hotani H, Hess B, Müller SC. Spatial patterns from oscillating microtubules. Science (New York, N.Y.). 246: 1291-3. PMID 2588005 DOI: 10.1126/Science.2588005  0.393
1989 von Massow A, Mandelkow EM, Mandelkow E. Interaction between kinesin, microtubules, and microtubule-associated protein 2. Cell Motility and the Cytoskeleton. 14: 562-71. PMID 2533884 DOI: 10.1002/Cm.970140413  0.377
1989 Hagestedt T, Lichtenberg B, Wille H, Mandelkow EM, Mandelkow E. Tau protein becomes long and stiff upon phosphorylation: correlation between paracrystalline structure and degree of phosphorylation. The Journal of Cell Biology. 109: 1643-51. PMID 2507554 DOI: 10.1083/Jcb.109.4.1643  0.495
1989 Mandelkow E, Lange G, Mandelkow E. Applications of synchrotron radiation to the study of biopolymers in solution: Time-resolved X-ray scattering of microtubule self-assembly and oscillations Topics in Current Chemistry. 151: 9-29. DOI: 10.1007/3540512012_11  0.319
1988 Mandelkow EM, Lange G, Jagla A, Spann U, Mandelkow E. Dynamics of the microtubule oscillator: role of nucleotides and tubulin-MAP interactions. The Embo Journal. 7: 357-65. PMID 3366117 DOI: 10.1002/J.1460-2075.1988.Tb02821.X  0.42
1988 Lange G, Mandelkow EM, Jagla A, Mandelkow E. Tubulin oligomers and microtubule oscillations. Antagonistic role of microtubule stabilizers and destabilizers. European Journal of Biochemistry / Febs. 178: 61-9. PMID 3203694 DOI: 10.1111/J.1432-1033.1988.Tb14429.X  0.409
1988 Lichtenberg B, Mandelkow EM, Hagestedt T, Mandelkow E. Structure and elasticity of microtubule-associated protein tau. Nature. 334: 359-62. PMID 3134620 DOI: 10.1038/334359A0  0.564
1987 Spann U, Renner W, Mandelkow EM, Bordas J, Mandelkow E. Tubulin oligomers and microtubule assembly studied by time-resolved X-ray scattering: separation of prenucleation and nucleation events. Biochemistry. 26: 1123-32. PMID 3567159 DOI: 10.1021/Bi00378A021  0.335
1986 Mandelkow EM, Schultheiss R, Rapp R, Müller M, Mandelkow E. On the surface lattice of microtubules: helix starts, protofilament number, seam, and handedness. The Journal of Cell Biology. 102: 1067-73. PMID 3949873 DOI: 10.1083/Jcb.102.3.1067  0.406
1986 Mandelkow EM, Mandelkow E. Cryo-electron microscopy of unstained frozen-hydrated microtubules. Methods in Enzymology. 134: 612-33. PMID 3821580 DOI: 10.1016/0076-6879(86)34126-0  0.307
1986 Mandelkow EM, Rapp R, Mandelkow E. Microtubule structure studied by quick freezing: cryo-electron microscopy and freeze fracture. Journal of Microscopy. 141: 361-73. PMID 3517351 DOI: 10.1111/J.1365-2818.1986.Tb02729.X  0.329
1986 Mandelkow E, Mandelkow EM. Quick-frozen microtubules studied by cryoelectron microscopy and image processing. Annals of the New York Academy of Sciences. 483: 13-23. PMID 3471120 DOI: 10.1111/J.1749-6632.1986.Tb34489.X  0.336
1986 Mandelkow E, Mandelkow EM, Bordas J. Microtubule assembly and disassembly studied by synchrotron X-ray scattering and cryoelectron microscopy. Annals of the New York Academy of Sciences. 466: 650-5. PMID 3460439 DOI: 10.1111/J.1749-6632.1986.Tb38444.X  0.308
1985 Mandelkow EM, Mandelkow E. Unstained microtubules studied by cryo-electron microscopy. Substructure, supertwist and disassembly. Journal of Molecular Biology. 181: 123-35. PMID 3981631 DOI: 10.1016/0022-2836(85)90330-4  0.321
1984 Mandelkow E, Schultheiss R, Mandelkow EM. Reconstructions of tubulin protofilaments: different appearances of the same structure. Ultramicroscopy. 13: 125-36. PMID 6474596 DOI: 10.1016/0304-3991(84)90063-9  0.324
1984 Mandelkow E, Schultheiss R, Mandelkow EM. Assembly and three-dimensional image reconstruction of tubulin hoops. Journal of Molecular Biology. 177: 507-29. PMID 6471102 DOI: 10.1016/0022-2836(84)90297-3  0.434
1983 Bordas J, Mandelkow EM, Mandelkow E. Stages of tubulin assembly and disassembly studied by time-resolved synchrotron X-ray scattering. Journal of Molecular Biology. 164: 89-135. PMID 6842593 DOI: 10.1016/0022-2836(83)90089-X  0.38
1983 Matsudaira P, Mandelkow E, Renner W, Hesterberg LK, Weber K. Role of fimbrin and villin in determining the interfilament distances of actin bundles. Nature. 301: 209-14. PMID 6823301 DOI: 10.1038/301209A0  0.324
1983 Schultheiss R, Mandelkow E. Three-dimensional reconstruction of tubulin sheets and re-investigation of microtubule surface lattice. Journal of Molecular Biology. 170: 471-96. PMID 6631967 DOI: 10.1016/S0022-2836(83)80158-2  0.332
1983 Mandelkow E, Mandelkow E, Bordas J. Synchrotron radiation as a tool for studying microtubule self-assembly Trends in Biochemical Sciences. 8: 374-377. DOI: 10.1016/0968-0004(83)90365-1  0.315
1981 Mandelkow E, Stubbs G, Warren S. Structures of the helical aggregates of tobacco mosaic virus protein. Journal of Molecular Biology. 152: 375-86. PMID 7328658 DOI: 10.1016/0022-2836(81)90248-5  0.339
1981 Renner W, Franke WW, Schmid E, Geisler N, Weber K, Mandelkow E. Reconstitution of intermediate-sized filaments from denatured monomeric vimentin. Journal of Molecular Biology. 149: 285-306. PMID 7310882 DOI: 10.1016/0022-2836(81)90303-X  0.385
1981 Mandelkow E, Mandelkow EM. Image reconstruction of tubulin hoops. Journal of Ultrastructure Research. 74: 11-33. PMID 7241636 DOI: 10.1016/S0022-5320(81)80106-2  0.359
1980 Mandelkow EM, Harmsen A, Mandelkow E, Bordas J. X-ray kinetic studies of microtubule assembly using synchrotron radiation. Nature. 287: 595-9. PMID 7432480 DOI: 10.1038/287595A0  0.354
1979 Stubbs G, Warren S, Mandelkow E. Structural comparisons of the aggregates of tobacco mosaic virus protein. Journal of Supramolecular Structure. 12: 177-83. PMID 544935 DOI: 10.1002/Jss.400120204  0.317
1979 Mandelkow EM, Mandelkow E. Junctions between microtubule walls. Journal of Molecular Biology. 129: 135-48. PMID 448734 DOI: 10.1016/0022-2836(79)90064-0  0.386
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