| Year |
Citation |
Score |
| 2024 |
da Silva ANR, Pereira GRC, Bonet LFS, Outeiro TF, De Mesquita JF. In silico analysis of alpha-synuclein protein variants and posttranslational modifications related to Parkinson's disease. Journal of Cellular Biochemistry. PMID 38239037 DOI: 10.1002/jcb.30523 |
0.359 |
|
| 2024 |
Quesnel A, Martin LD, Tarzi C, Lenis VP, Coles N, Islam M, Angione C, Outeiro TF, Khundakar AA, Filippou PS. Uncovering potential diagnostic and pathophysiological roles of α-synuclein and DJ-1 in melanoma. Cancer Medicine. PMID 38189631 DOI: 10.1002/cam4.6900 |
0.345 |
|
| 2023 |
Vieira TCRG, Barros CA, Domingues R, Outeiro TF. PrP meets alpha-synuclein: Molecular mechanisms and implications for disease. Journal of Neurochemistry. PMID 37855859 DOI: 10.1111/jnc.15992 |
0.363 |
|
| 2023 |
Brembati V, Faustini G, Longhena F, Outeiro TF, Bellucci A. Changes in α-Synuclein Posttranslational Modifications in an AAV-Based Mouse Model of Parkinson's Disease. International Journal of Molecular Sciences. 24. PMID 37686236 DOI: 10.3390/ijms241713435 |
0.34 |
|
| 2023 |
Sant'Anna R, Robbs BK, de Freitas JA, Dos Santos PP, König A, Outeiro TF, Foguel D. The alpha-synuclein oligomers activate nuclear factor of activated T-cell (NFAT) modulating synaptic homeostasis and apoptosis. Molecular Medicine (Cambridge, Mass.). 29: 111. PMID 37596531 DOI: 10.1186/s10020-023-00704-8 |
0.313 |
|
| 2023 |
Chopra A, Outeiro TF. Aggregation and beyond: alpha-synuclein-based biomarkers in synucleinopathies. Brain : a Journal of Neurology. PMID 37526295 DOI: 10.1093/brain/awad260 |
0.39 |
|
| 2023 |
Warth Perez Arias CC, Silbern I, Caldi Gomes L, Wartmann H, Dambeck V, Fanz J, Neuenroth L, Bähr M, Outeiro TF, Bonn S, Stadelmann-Nessler C, Rizzoli SO, Lenz C, Urlaub H, Lingor P. Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage Parkinson's disease. Journal of Neurochemistry. 166: 862-874. PMID 37515330 DOI: 10.1111/jnc.15924 |
0.3 |
|
| 2023 |
Flores-Leon M, Outeiro TF. More than meets the eye in Parkinson's disease and other synucleinopathies: from proteinopathy to lipidopathy. Acta Neuropathologica. PMID 37421475 DOI: 10.1007/s00401-023-02601-0 |
0.342 |
|
| 2023 |
Gasparotto J, Somensi N, Girardi CS, Bittencourt RR, de Oliveira LM, Hoefel LP, Scheibel IM, Peixoto DO, Moreira JCF, Outeiro TF, Gelain DP. Is it all the RAGE? Defining the role of the receptor for advanced glycation end products in Parkinson's disease. Journal of Neurochemistry. PMID 37381043 DOI: 10.1111/jnc.15890 |
0.324 |
|
| 2023 |
Gelain DP, Bittencourt RR, Bastos Mendes LF, Moreira JCF, Outeiro TF. RAGE Against the Glycation Machine in Synucleinopathies: Time to Explore New Questions. Journal of Parkinson's Disease. PMID 37270812 DOI: 10.3233/JPD-230070 |
0.338 |
|
| 2023 |
Outeiro TF, Alcalay RN, Antonini A, Attems J, Bonifati V, Cardoso F, Chesselet MF, Hardy J, Madeo G, McKeith I, Mollenhauer B, Moore DJ, Rascol O, Schlossmacher MG, Soreq H, et al. Defining the Riddle in Order to Solve It: There Is More Than One "Parkinson's Disease". Movement Disorders : Official Journal of the Movement Disorder Society. PMID 37156737 DOI: 10.1002/mds.29419 |
0.305 |
|
| 2023 |
Rosado-Ramos R, Poças GM, Marques D, Foito A, M Sevillano D, Lopes-da-Silva M, Gonçalves LG, Menezes R, Ottens M, Stewart D, Ibáñez de Opakua A, Zweckstetter M, Seabra MC, Mendes CS, Outeiro TF, et al. Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage. Nature Communications. 14: 1918. PMID 37024503 DOI: 10.1038/s41467-023-37561-2 |
0.375 |
|
| 2023 |
Shvachiy L, Geraldes V, Outeiro T. Uncovering the molecular link between lead toxicity and Parkinson's disease. Antioxidants & Redox Signaling. PMID 36641635 DOI: 10.1089/ars.2022.0076 |
0.345 |
|
| 2022 |
Santos CC, Cardim-Pires TR, Shvachiy L, Fonseca-Fonseca LA, Muñoz P, Almeida ÁMAN, Costa ACS, Teles-Souza J, Ochoa-Rodríguez E, de Fátima Dias Costa M, Palhano FL, Segura-Aguilar J, Barbosa DB, do Bomfim MR, Dos Santos Junior MC, ... ... Outeiro TF, et al. JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species. Neurotoxicity Research. PMID 35997936 DOI: 10.1007/s12640-022-00559-7 |
0.367 |
|
| 2022 |
Schaffner SL, Wassouf Z, Lazaro DF, Xylaki M, Gladish N, Lin DTS, MacIsaac J, Ramadori K, Hentrich T, Schulze-Hentrich JM, Outeiro TF, Kobor MS. Alpha-synuclein overexpression induces epigenomic dysregulation of glutamate signaling and locomotor pathways. Human Molecular Genetics. PMID 35567546 DOI: 10.1093/hmg/ddac104 |
0.305 |
|
| 2022 |
Chegão A, Guarda M, Alexandre BM, Shvachiy L, Temido-Ferreira M, Marques-Morgado I, Fernandes Gomes B, Matthiesen R, Lopes LV, Florindo PR, Gomes RA, Gomes-Alves P, Coelho JE, Outeiro TF, Vicente Miranda H. Glycation modulates glutamatergic signaling and exacerbates Parkinson's disease-like phenotypes. Npj Parkinson's Disease. 8: 51. PMID 35468899 DOI: 10.1038/s41531-022-00314-x |
0.355 |
|
| 2022 |
Cassotta M, Geerts H, Harbom L, Outeiro TF, Pediaditakis I, Reiner O, Schildknecht S, Schwamborn JC, Bailey J, Herrmann K, Hogberg HT. The future of Parkinson's disease research: A new paradigm of human-specific investigation is necessary… and possible. Altex. PMID 35404466 DOI: 10.14573/altex.2203161 |
0.308 |
|
| 2022 |
Domingues R, Sant'Anna R, da Fonseca ACC, Robbs BK, Foguel D, Outeiro TF. Extracellular alpha-synuclein: Sensors, receptors, and responses. Neurobiology of Disease. 168: 105696. PMID 35321855 DOI: 10.1016/j.nbd.2022.105696 |
0.301 |
|
| 2022 |
Farzadfard A, König A, Petersen SV, Nielsen J, Vasili E, Dominguez-Meijide A, Buell AK, Outeiro TF, Otzen DE. Glycation modulates alpha-synuclein fibrillization kinetics: a sweet spot for inhibition. The Journal of Biological Chemistry. 101848. PMID 35314196 DOI: 10.1016/j.jbc.2022.101848 |
0.356 |
|
| 2022 |
Al-Azzani M, König A, Outeiro TF. Production of Recombinant Alpha-Synuclein: Still No Standardized Protocol in Sight. Biomolecules. 12. PMID 35204823 DOI: 10.3390/biom12020324 |
0.347 |
|
| 2022 |
Torres-Garcia L, P Domingues JM, Brandi E, Haikal C, Mudannayake JM, Brás IC, Gerhardt E, Li W, Svanbergsson A, Outeiro TF, Gouras GK, Li JY. Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation. Scientific Reports. 12: 2987. PMID 35194057 DOI: 10.1038/s41598-022-06846-9 |
0.345 |
|
| 2022 |
Hatton C, Ghanem SS, Koss DJ, Abdi IY, Gibbons E, Guerreiro R, Bras J, Walker L, Gelpi E, Heywood W, Outeiro TF, Attems J, McFarland R, Forsyth R, et al. Prion-like α-synuclein pathology in the brain of infants with Krabbe disease. Brain : a Journal of Neurology. PMID 34999780 DOI: 10.1093/brain/awac002 |
0.32 |
|
| 2022 |
Vasili E, Dominguez-Meijide A, Flores-León M, Al-Azzani M, Kanellidi A, Melki R, Stefanis L, Outeiro TF. Endogenous Levels of Alpha-Synuclein Modulate Seeding and Aggregation in Cultured Cells. Molecular Neurobiology. 59: 1273-1284. PMID 34984585 DOI: 10.1007/s12035-021-02713-2 |
0.339 |
|
| 2021 |
Oliveira LMA, Gasser T, Edwards R, Zweckstetter M, Melki R, Stefanis L, Lashuel HA, Sulzer D, Vekrellis K, Halliday GM, Tomlinson JJ, Schlossmacher M, Jensen PH, Schulze-Hentrich J, Riess O, ... ... Outeiro TF, et al. Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease. Npj Parkinson's Disease. 7: 65. PMID 34312398 DOI: 10.1038/s41531-021-00203-9 |
0.345 |
|
| 2021 |
Albert K, Raymundo DP, Panhelainen A, Eesmaa A, Shvachiy L, Araújo GR, Chmielarz P, Yan X, Singh A, Cordeiro Y, Palhano FL, Foguel D, Luk KC, Domanskyi A, Voutilainen MH, ... ... Outeiro TF, et al. Cerebral Dopamine Neurotrophic Factor Reduces α-Synuclein Aggregation and Propagation and Alleviates Behavioural Alterations in vivo. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 33940158 DOI: 10.1016/j.ymthe.2021.04.035 |
0.33 |
|
| 2021 |
Koss DJ, Campesan S, Giorgini F, Outeiro TF. Dysfunction of RAB39B-Mediated Vesicular Trafficking in Lewy Body Diseases. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 33939203 DOI: 10.1002/mds.28605 |
0.367 |
|
| 2021 |
Medina L, González-Lizárraga F, Dominguez-Meijide A, Ploper D, Parrales V, Sequeira S, Cima-Omori MS, Zweckstetter M, Del Bel E, Michel PP, Outeiro TF, Raisman-Vozari R, Chehín R, Socias SB. Doxycycline Interferes With Tau Aggregation and Reduces Its Neuronal Toxicity. Frontiers in Aging Neuroscience. 13: 635760. PMID 33828477 DOI: 10.3389/fnagi.2021.635760 |
0.333 |
|
| 2021 |
Brás IC, Outeiro TF. Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies. Cells. 10. PMID 33673034 DOI: 10.3390/cells10020375 |
0.4 |
|
| 2021 |
Erskine D, Koss D, Korolchuk VI, Outeiro TF, Attems J, McKeith I. Lipids, lysosomes and mitochondria: insights into Lewy body formation from rare monogenic disorders. Acta Neuropathologica. PMID 33515275 DOI: 10.1007/s00401-021-02266-7 |
0.367 |
|
| 2021 |
Dominguez-Meijide A, Parrales V, Vasili E, González-Lizárraga F, König A, Lázaro DF, Lannuzel A, Haik S, Del Bel E, Chehín R, Raisman-Vozari R, Michel PP, Bizat N, Outeiro TF. Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo. Neurobiology of Disease. 105256. PMID 33429042 DOI: 10.1016/j.nbd.2021.105256 |
0.388 |
|
| 2020 |
Filippou PS, Outeiro TF. Cancer and Parkinson's Disease: Common Targets, Emerging Hopes. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 33346940 DOI: 10.1002/mds.28425 |
0.306 |
|
| 2020 |
Outeiro TF, Heutink P, Bezard E, Cenci AM. From iPS Cells to Rodents and Nonhuman Primates: Filling Gaps in Modeling Parkinson's Disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 33200446 DOI: 10.1002/mds.28387 |
0.371 |
|
| 2020 |
Menezes R, Foito A, Jardim C, Costa I, Garcia G, Rosado-Ramos R, Freitag S, Alexander CJ, Outeiro TF, Stewart D, Santos CN. Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases. Antioxidants (Basel, Switzerland). 9. PMID 32858836 DOI: 10.3390/Antiox9090789 |
0.307 |
|
| 2020 |
Morato Torres CA, Wassouf Z, Zafar F, Sastre D, Outeiro TF, Schüle B. The Role of Alpha-Synuclein and Other Parkinson's Genes in Neurodevelopmental and Neurodegenerative Disorders. International Journal of Molecular Sciences. 21. PMID 32785033 DOI: 10.3390/ijms21165724 |
0.364 |
|
| 2020 |
Koss DJ, Bondarevaite O, Adams S, Leite M, Giorgini F, Attems J, Outeiro TF. RAB39B is redistributed in dementia with lewy bodies and is sequestered within Aβ plaques and lewy bodies. Brain Pathology (Zurich, Switzerland). PMID 32762091 DOI: 10.1111/Bpa.12890 |
0.426 |
|
| 2020 |
Dominguez-Meijide A, Vasili E, König A, Cima-Omori MS, Ibáñez de Opakua A, Leonov A, Ryazanov S, Zweckstetter M, Griesinger C, Outeiro TF. Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization. Scientific Reports. 10: 12827. PMID 32732936 DOI: 10.1038/S41598-020-69744-Y |
0.486 |
|
| 2020 |
Santos PI, Outeiro TF. Protein trapping leads to altered synaptic proteostasis in synucleinopathies. The Febs Journal. PMID 32400966 DOI: 10.1111/Febs.15364 |
0.488 |
|
| 2020 |
Cukierman DS, Lázaro DF, Sacco P, Ferreira PR, Diniz R, Fernández CO, Outeiro TF, Rey NA. X1INH, an improved next-generation affinity-optimized hydrazonic ligand, attenuates abnormal copper(i)/copper(ii)-α-Syn interactions and affects protein aggregation in a cellular model of synucleinopathy. Dalton Transactions (Cambridge, England : 2003). PMID 32391542 DOI: 10.1039/D0Dt01138J |
0.41 |
|
| 2020 |
Lázaro DF, Outeiro TF. The Interplay Between Proteostasis Systems and Parkinson's Disease. Advances in Experimental Medicine and Biology. 1233: 223-236. PMID 32274759 DOI: 10.1007/978-3-030-38266-7_9 |
0.507 |
|
| 2020 |
Francelle L, Outeiro TF, Rappold GA. Inhibition of HDAC6 activity protects dopaminergic neurons from alpha-synuclein toxicity. Scientific Reports. 10: 6064. PMID 32269243 DOI: 10.1038/S41598-020-62678-5 |
0.508 |
|
| 2020 |
Vicente Miranda H, Chegão A, Oliveira MS, Fernandes Gomes B, Enguita FJ, Outeiro TF. Hsp27 reduces glycation-induced toxicity and aggregation of alpha-synuclein. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32259355 DOI: 10.1096/Fj.201902936R |
0.457 |
|
| 2020 |
Vale N, Alves C, Sharma V, Lázaro DF, Silva S, Gomes P, Outeiro TF. A new MAP-Rasagiline conjugate reduces α-synuclein inclusion formation in a cell model. Pharmacological Reports : Pr. PMID 32048262 DOI: 10.1007/S43440-019-00032-X |
0.491 |
|
| 2020 |
Brás IC, Dominguez-Meijide A, Gerhardt E, Koss D, Lázaro DF, Santos PI, Vasili E, Xylaki M, Outeiro TF. Synucleinopathies: Where we are and where we need to go. Journal of Neurochemistry. e14965. PMID 31957016 DOI: 10.1111/Jnc.14965 |
0.419 |
|
| 2020 |
Outeiro TF, Mestre TA. Synuclein Meeting 2019: where we are and where we need to go. Journal of Neurochemistry. 150: 462-466. PMID 31441047 DOI: 10.1111/Jnc.14825 |
0.401 |
|
| 2020 |
Brás IC, König A, Outeiro TF. Glycation in Huntington's Disease: A Possible Modifier and Target for Intervention. Journal of Huntington's Disease. 8: 245-256. PMID 31322580 DOI: 10.3233/Jhd-190366 |
0.46 |
|
| 2019 |
Brás IC, Xylaki M, Outeiro TF. Mechanisms of alpha-synuclein toxicity: An update and outlook. Progress in Brain Research. 252: 91-129. PMID 32247376 DOI: 10.1016/Bs.Pbr.2019.10.005 |
0.449 |
|
| 2019 |
Lázaro DF, Bellucci A, Brundin P, Outeiro TF. Editorial: Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases. Frontiers in Molecular Neuroscience. 12: 312. PMID 32009897 DOI: 10.3389/Fnmol.2019.00312 |
0.416 |
|
| 2019 |
Brasil AA, de Carvalho MDC, Gerhardt E, Queiroz DD, Pereira MD, Outeiro TF, Eleutherio ECA. Characterization of the activity, aggregation, and toxicity of heterodimers of WT and ALS-associated mutant Sod1. Proceedings of the National Academy of Sciences of the United States of America. PMID 31796595 DOI: 10.1073/Pnas.1902483116 |
0.335 |
|
| 2019 |
Vaz RL, Sousa S, Chapela D, van der Linde HC, Willemsen R, Correia AD, Outeiro TF, Afonso ND. Identification of antiparkinsonian drugs in the 6-hydroxydopamine zebrafish model. Pharmacology, Biochemistry, and Behavior. 172828. PMID 31785245 DOI: 10.1016/J.Pbb.2019.172828 |
0.404 |
|
| 2019 |
Vaz RL, Chapela D, Coelho JE, Lopes LV, Ferreira JJ, Afonso ND, Sousa S, Outeiro TF. Tapentadol Prevents Motor Impairments in a Mouse Model of Dyskinesia. Neuroscience. PMID 31682948 DOI: 10.1016/J.Neuroscience.2019.08.046 |
0.427 |
|
| 2019 |
Masaracchia C, König A, Valiente-Gabioud AA, Peralta P, Favretto F, Strohäker T, Lázaro DF, Zweckstetter M, Fernandez CO, Outeiro TF. Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies. Biochimica Et Biophysica Acta. Proteins and Proteomics. 1868: 140298. PMID 31676453 DOI: 10.1016/J.Bbapap.2019.140298 |
0.42 |
|
| 2019 |
Correia Guedes L, Mestre T, Outeiro TF, Ferreira JJ. Are genetic and idiopathic forms of Parkinson's disease the same disease? Journal of Neurochemistry. PMID 31643079 DOI: 10.1111/Jnc.14902 |
0.428 |
|
| 2019 |
Ferreira C, Couceiro J, Família C, Jardim C, Antas P, Santos CN, Outeiro TF, Tenreiro S, Quintas A. The synthetic cannabinoid JWH-018 modulates Saccharomyces cerevisiae energetic metabolism. Fems Yeast Research. 19. PMID 31329229 DOI: 10.1093/Femsyr/Foz042 |
0.326 |
|
| 2019 |
Szegő ÉM, Dominguez-Meijide A, Gerhardt E, König A, Koss DJ, Li W, Pinho R, Fahlbusch C, Johnson M, Santos P, Villar-Piqué A, Thom T, Rizzoli S, Schmitz M, Li J, ... ... Outeiro TF, et al. Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies. Cell Reports. 28: 65-77.e6. PMID 31269451 DOI: 10.1016/J.Celrep.2019.06.009 |
0.344 |
|
| 2019 |
Delenclos M, Burgess JD, Lamprokostopoulou A, Outeiro TF, Vekrellis K, McLean PJ. Cellular models of alpha-synuclein toxicity and aggregation. Journal of Neurochemistry. PMID 31265132 DOI: 10.1111/Jnc.14806 |
0.464 |
|
| 2019 |
Wu JZ, Ardah M, Haikal C, Svanbergsson A, Diepenbroek M, Vaikath NN, Li W, Wang ZY, Outeiro TF, El-Agnaf OM, Li JY. Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy. Translational Neurodegeneration. 8: 18. PMID 31223479 DOI: 10.1186/S40035-019-0159-7 |
0.457 |
|
| 2019 |
Vasili E, Dominguez-Meijide A, Outeiro TF. Spreading of α-Synuclein and Tau: A Systematic Comparison of the Mechanisms Involved. Frontiers in Molecular Neuroscience. 12: 107. PMID 31105524 DOI: 10.3389/Fnmol.2019.00107 |
0.529 |
|
| 2019 |
González N, Arcos-López T, König A, Quintanar L, Menacho Márquez M, Outeiro TF, Fernández CO. Effects of alpha-synuclein posttranslational modifications on metal binding. Journal of Neurochemistry. PMID 31099098 DOI: 10.1111/Jnc.14721 |
0.412 |
|
| 2019 |
Outeiro TF, Harvey K, Dominguez-Meijide A, Gerhardt E. LRRK2, alpha-synuclein, and tau: partners in crime or unfortunate bystanders? Biochemical Society Transactions. PMID 31085616 DOI: 10.1042/Bst20180466 |
0.505 |
|
| 2019 |
Rossetti G, Kless A, Lai L, Outeiro TF, Carloni P. Investigating targets for neuropharmacological intervention by molecular dynamics simulations. Biochemical Society Transactions. PMID 31085614 DOI: 10.1042/Bst20190048 |
0.337 |
|
| 2019 |
Marvian AT, Koss DJ, Aliakbari F, Morshedi D, Outeiro TF. In vitro models of synucleinopathies: informing on molecular mechanisms and protective strategies. Journal of Neurochemistry. 150: 535-565. PMID 31004503 DOI: 10.1111/Jnc.14707 |
0.469 |
|
| 2019 |
Sampaio-Marques B, Guedes A, Vasilevskiy I, Gonçalves S, Outeiro TF, Winderickx J, Burhans WC, Ludovico P. α-Synuclein toxicity in yeast and human cells is caused by cell cycle re-entry and autophagy degradation of ribonucleotide reductase 1. Aging Cell. e12922. PMID 30977294 DOI: 10.1111/Acel.12922 |
0.366 |
|
| 2019 |
Candelise N, Schmitz M, Llorens F, Villar-Piqué A, Cramm M, Thom T, da Silva Correia SM, Eriton Gomes da Cunha J, Möbius W, Outeiro TF, Álvarez VG, Banchelli M, D'Andrea C, de Angelis M, Zafar S, et al. Seeding variability of different alpha synuclein strains in synucleinopathies. Annals of Neurology. PMID 30805957 DOI: 10.1002/Ana.25446 |
0.418 |
|
| 2019 |
Gong J, Szegő ÉM, Leonov A, Benito E, Becker S, Fischer A, Zweckstetter M, Outeiro T, Schneider A. Translocator protein ligand protects against neurodegeneration in the MPTP mouse model of Parkinsonism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30796158 DOI: 10.1523/Jneurosci.2070-18.2019 |
0.465 |
|
| 2019 |
Brás IC, Popova B, Braus GH, Outeiro TF. Yeast-Based Screens to Target Alpha-Synuclein Toxicity. Methods in Molecular Biology (Clifton, N.J.). 1948: 145-156. PMID 30771176 DOI: 10.1007/978-1-4939-9124-2_12 |
0.432 |
|
| 2019 |
Carija A, Pinheiro F, Pujols J, Brás IC, Lázaro DF, Santambrogio C, Grandori R, Outeiro TF, Navarro S, Ventura S. Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity. Redox Biology. 22: 101135. PMID 30769283 DOI: 10.1016/J.Redox.2019.101135 |
0.419 |
|
| 2019 |
Outeiro TF, Koss DJ, Erskine D, Walker L, Kurzawa-Akanbi M, Burn D, Donaghy P, Morris C, Taylor JP, Thomas A, Attems J, McKeith I. Dementia with Lewy bodies: an update and outlook. Molecular Neurodegeneration. 14: 5. PMID 30665447 DOI: 10.1186/S13024-019-0306-8 |
0.425 |
|
| 2019 |
König A, Vicente Miranda H, Outeiro TF. Alpha-Synuclein Glycation and the Action of Anti-Diabetic Agents in Parkinson's Disease. Journal of Parkinson's Disease. 8: 33-43. PMID 29480231 DOI: 10.3233/Jpd-171285 |
0.447 |
|
| 2018 |
Harvey K, Outeiro TF. The role of LRRK2 in cell signalling. Biochemical Society Transactions. PMID 30578345 DOI: 10.1042/Bst20180464 |
0.426 |
|
| 2018 |
Chiang AN, Liang M, Dominguez-Meijide A, Masaracchia C, Goeckeler-Fried JL, Mazzone CS, Newhouse DW, Kendsersky NM, Yates ME, Manos-Turvey A, Needham PG, Outeiro TF, Wipf P, Brodsky JL. Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding. Bioorganic & Medicinal Chemistry. PMID 30528127 DOI: 10.1016/J.Bmc.2018.11.011 |
0.456 |
|
| 2018 |
Brás IC, Lopes LV, Outeiro TF. Sensing α-Synuclein From the Outside via the Prion Protein: Implications for Neurodegeneration. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 30423195 DOI: 10.1002/Mds.27478 |
0.457 |
|
| 2018 |
Gustafsson G, Lööv C, Persson E, Lázaro DF, Takeda S, Bergström J, Erlandsson A, Sehlin D, Balaj L, György B, Hallbeck M, Outeiro TF, Breakefield XO, Hyman BT, Ingelsson M. Secretion and Uptake of α-Synuclein Via Extracellular Vesicles in Cultured Cells. Cellular and Molecular Neurobiology. PMID 30288631 DOI: 10.1007/S10571-018-0622-5 |
0.365 |
|
| 2018 |
Brás IC, Tenreiro S, Silva AM, Outeiro TF. Identification of novel protein phosphatases as modifiers of alpha-synuclein aggregation in yeast. Fems Yeast Research. PMID 30277516 DOI: 10.1093/Femsyr/Foy108 |
0.419 |
|
| 2018 |
Prasad V, Wasser Y, Hans F, Goswami A, Katona I, Outeiro TF, Kahle PJ, Schulz JB, Voigt A. Monitoring α-synuclein multimerization in vivo. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201800148RRR. PMID 30252534 DOI: 10.1096/Fj.201800148Rrr |
0.392 |
|
| 2018 |
Pujols J, Peña-Díaz S, Lázaro DF, Peccati F, Pinheiro F, González D, Carija A, Navarro S, Conde-Giménez M, García J, Guardiola S, Giralt E, Salvatella X, Sancho J, Sodupe M, ... Outeiro TF, et al. Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons. Proceedings of the National Academy of Sciences of the United States of America. PMID 30249646 DOI: 10.1073/Pnas.1804198115 |
0.456 |
|
| 2018 |
Pinho R, Paiva I, Jercic KG, Fonseca-Ornelas L, Gerhardt E, Fahlbusch C, Garcia-Esparcia P, Kerimoglu C, Pavlou MA, Villar-Piqué A, Szego É, Fonseca TL, Odoardi F, Soeroes S, Rego AC, ... ... Outeiro TF, et al. Nuclear localization and phosphorylation modulate pathological effects of Alpha-Synuclein. Human Molecular Genetics. PMID 30219847 DOI: 10.1093/Hmg/Ddy326 |
0.425 |
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| 2018 |
Masaracchia C, Hnida M, Gerhardt E, Lopes da Fonseca T, Villar-Pique A, Branco T, Stahlberg MA, Dean C, Fernández CO, Milosevic I, Outeiro TF. Membrane binding, internalization, and sorting of alpha-synuclein in the cell. Acta Neuropathologica Communications. 6: 79. PMID 30107856 DOI: 10.1186/S40478-018-0578-1 |
0.436 |
|
| 2018 |
Paiva I, Jain G, Lázaro DF, Jerčić KG, Hentrich T, Kerimoglu C, Pinho R, Szegő ÈM, Burkhardt S, Capece V, Halder R, Islam R, Xylaki M, Caldi Gomes LA, Roser AE, ... ... Outeiro TF, et al. Alpha-synuclein deregulates the expression of COL4A2 and impairs ER-Golgi function. Neurobiology of Disease. PMID 30092270 DOI: 10.1016/J.Nbd.2018.08.001 |
0.471 |
|
| 2018 |
Vaz RL, Outeiro TF, Ferreira JJ. Zebrafish as an Animal Model for Drug Discovery in Parkinson's Disease and Other Movement Disorders: A Systematic Review. Frontiers in Neurology. 9: 347. PMID 29910763 DOI: 10.3389/Fneur.2018.00347 |
0.387 |
|
| 2018 |
Macedo D, Jardim C, Figueira I, Almeida AF, McDougall GJ, Stewart D, Yuste JE, Tomás-Barberán FA, Tenreiro S, Outeiro TF, Santos CN. (Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis. Scientific Reports. 8: 6965. PMID 29725038 DOI: 10.1038/S41598-018-25118-Z |
0.488 |
|
| 2018 |
Repici M, Hassanjani M, Maddison DC, Garção P, Cimini S, Patel B, Szegö ÉM, Straatman KR, Lilley KS, Borsello T, Outeiro TF, Panman L, Giorgini F. The Parkinson's Disease-Linked Protein DJ-1 Associates with Cytoplasmic mRNP Granules During Stress and Neurodegeneration. Molecular Neurobiology. PMID 29675578 DOI: 10.1007/S12035-018-1084-Y |
0.377 |
|
| 2018 |
Biosa A, Outeiro TF, Bubacco L, Bisaglia M. Diabetes Mellitus as a Risk Factor for Parkinson's Disease: a Molecular Point of View. Molecular Neurobiology. PMID 29594935 DOI: 10.1007/S12035-018-1025-9 |
0.416 |
|
| 2018 |
Valiente-Gabioud AA, Riedel D, Outeiro TF, Menacho-Márquez MA, Griesinger C, Fernández CO. Binding Modes of Phthalocyanines to Amyloid β Peptide and Their Effects on Amyloid Fibril Formation. Biophysical Journal. 114: 1036-1045. PMID 29539391 DOI: 10.1016/J.Bpj.2018.01.003 |
0.361 |
|
| 2018 |
Tenreiro S, Franssens V, Winderickx J, Outeiro TF. Yeast models of Parkinson's disease-associated molecular pathologies. Current Opinion in Genetics & Development. 44: 74-83. PMID 28232272 DOI: 10.1016/J.Gde.2017.01.013 |
0.444 |
|
| 2018 |
Tenreiro S, Macedo D, Marijanovic Z, Outeiro TF. Analysis of Protein Oligomeric Species by Sucrose Gradients. Methods in Molecular Biology (Clifton, N.J.). 1449: 331-9. PMID 27613047 DOI: 10.1007/978-1-4939-3756-1_21 |
0.402 |
|
| 2017 |
Vicente Miranda H, Cássio R, Correia-Guedes L, Gomes MA, Chegão A, Miranda E, Soares T, Coelho M, Rosa MM, Ferreira JJ, Outeiro TF. Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's disease. Scientific Reports. 7: 13713. PMID 29057912 DOI: 10.1038/S41598-017-14175-5 |
0.454 |
|
| 2017 |
Ferreira DG, Temido-Ferreira M, Miranda HV, Batalha VL, Coelho JE, Szegö ÉM, Marques-Morgado I, Vaz SH, Rhee JS, Schmitz M, Zerr I, Lopes LV, Outeiro TF. α-synuclein interacts with PrP(C) to induce cognitive impairment through mGluR5 and NMDAR2B. Nature Neuroscience. PMID 28945221 DOI: 10.1038/Nn.4648 |
0.341 |
|
| 2017 |
Branco-Santos J, Herrera F, Poças GM, Pires-Afonso Y, Giorgini F, Domingos PM, Outeiro TF. Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity. Human Molecular Genetics. 26: 3763-3775. PMID 28934390 DOI: 10.1093/Hmg/Ddx260 |
0.437 |
|
| 2017 |
López-León M, Outeiro TF, Goya RG. CELL REPROGRAMMING: THERAPEUTIC POTENTIAL AND THE PROMISE OF REJUVENATION FOR THE AGING BRAIN. Ageing Research Reviews. PMID 28903069 DOI: 10.1016/J.Arr.2017.09.002 |
0.403 |
|
| 2017 |
Guedes LC, Chan RB, Gomes MA, Conceição VA, Machado RB, Soares T, Xu Y, Gaspar P, Carriço JA, Alcalay RN, Ferreira JJ, Outeiro TF, Miltenberger-Miltenyi G. Serum lipid alterations in GBA-associated Parkinson's disease. Parkinsonism & Related Disorders. PMID 28890071 DOI: 10.1016/J.Parkreldis.2017.08.026 |
0.384 |
|
| 2017 |
Brasil AA, Magalhães RSS, De Carvalho MDC, Paiva I, Gerhardt E, Pereira MD, Outeiro TF, Eleutherio ECA. Implications of fALS Mutations on Sod1 Function and Oligomerization in Cell Models. Molecular Neurobiology. PMID 28884318 DOI: 10.1007/S12035-017-0755-4 |
0.321 |
|
| 2017 |
Correia Guedes L, Reimão S, Paulino P, Nunes RG, Bouça-Machado R, Abreu D, Gonçalves N, Soares T, Fabbri M, Godinho C, Pita Lobo P, Neutel D, Quadri M, Coelho M, Rosa MM, ... ... Outeiro TF, et al. Neuromelanin magnetic resonance imaging of the substantia nigra in LRRK2-related Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 28686310 DOI: 10.1002/Mds.27083 |
0.316 |
|
| 2017 |
Marciniak E, Leboucher A, Caron E, Ahmed T, Tailleux A, Dumont J, Issad T, Gerhardt E, Pagesy P, Vileno M, Bournonville C, Hamdane M, Bantubungi K, Lancel S, Demeyer D, ... ... Outeiro TF, et al. Tau deletion promotes brain insulin resistance. The Journal of Experimental Medicine. PMID 28652303 DOI: 10.1084/Jem.20161731 |
0.327 |
|
| 2017 |
Turriani E, Lázaro DF, Ryazanov S, Leonov A, Giese A, Schön M, Schön MP, Griesinger C, Outeiro TF, Arndt-Jovin DJ, Becker D. Treatment with diphenyl-pyrazole compound anle138b/c reveals that α-synuclein protects melanoma cells from autophagic cell death. Proceedings of the National Academy of Sciences of the United States of America. PMID 28584093 DOI: 10.1073/Pnas.1700200114 |
0.427 |
|
| 2017 |
Moreira S, Fonseca I, Nunes MJ, Rosa A, Lemos L, Rodrigues E, Carvalho AN, Outeiro TF, Rodrigues CMP, Gama MJ, Castro-Caldas M. Nrf2 activation by tauroursodeoxycholic acid in experimental models of Parkinson's disease. Experimental Neurology. PMID 28552716 DOI: 10.1016/J.Expneurol.2017.05.009 |
0.433 |
|
| 2017 |
Lázaro DF, Pavlou MAS, Outeiro TF. Cellular models as tools for the study of the role of alpha-synuclein in Parkinson's disease. Experimental Neurology. 298: 162-171. PMID 28526239 DOI: 10.1016/J.Expneurol.2017.05.007 |
0.514 |
|
| 2017 |
Pavlou MAS, Outeiro TF. Epigenetics in Parkinson's Disease. Advances in Experimental Medicine and Biology. 978: 363-390. PMID 28523556 DOI: 10.1007/978-3-319-53889-1_19 |
0.44 |
|
| 2017 |
Szegő ÉM, Gerhardt E, Outeiro TF. Sirtuin 2 enhances dopaminergic differentiation via the AKT/GSK-3β/β-catenin pathway. Neurobiology of Aging. 56: 7-16. PMID 28478325 DOI: 10.1016/J.Neurobiolaging.2017.04.001 |
0.345 |
|
| 2017 |
Vicente Miranda H, Szego ÉM, Oliveira LM, Breda C, Darendelioglu E, de Oliveira RM, Ferreira DG, Gomes MA, Rott R, Oliveira M, Munari F, Enguita FJ, Simões T, Rodrigues EF, Heinrich M, ... ... Outeiro TF, et al. Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies. Brain : a Journal of Neurology. PMID 28398476 DOI: 10.1093/Brain/Awx056 |
0.446 |
|
| 2017 |
Paiva I, Pinho R, Pavlou MA, Hennion M, Wales P, Schütz AL, Rajput A, Szego É, Kerimoglu C, Gerhardt E, Cristina Rego A, Fischer A, Bonn S, Outeiro TF. Sodium Butyrate Rescues Dopaminergic Cells from Alpha-Synuclein-Induced Transcriptional Deregulation and Dna damage. Human Molecular Genetics. PMID 28369321 DOI: 10.1093/Hmg/Ddx114 |
0.415 |
|
| 2017 |
Villar-Piqué A, Rossetti G, Ventura S, Carloni P, Fernández CO, Outeiro TF. Copper(II) and the pathological H50Q α-synuclein mutant: Environment meets genetics. Communicative & Integrative Biology. 10: e1270484. PMID 28289488 DOI: 10.1080/19420889.2016.1270484 |
0.401 |
|
| 2017 |
de Oliveira RM, Vicente Miranda H, Francelle L, Pinho R, Szegö ÉM, Martinho R, Munari F, Lázaro DF, Moniot S, Guerreiro P, Fonseca L, Marijanovic Z, Antas P, Gerhardt E, Enguita FJ, ... ... Outeiro TF, et al. The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease. Plos Biology. 15: e2000374. PMID 28257421 DOI: 10.1371/Journal.Pbio.2000374 |
0.503 |
|
| 2017 |
Cukierman DS, Pinheiro AB, Castiñeiras-Filho SL, da Silva AS, Miotto MC, De Falco A, de P Ribeiro T, Maisonette S, da Cunha AL, Hauser-Davis RA, Landeira-Fernandez J, Aucélio RQ, Outeiro TF, Pereira MD, Fernández CO, et al. A moderate metal-binding hydrazone meets the criteria for a bioinorganic approach towards Parkinson's disease: Therapeutic potential, blood-brain barrier crossing evaluation and preliminary toxicological studies. Journal of Inorganic Biochemistry. 170: 160-168. PMID 28249224 DOI: 10.1016/J.Jinorgbio.2017.02.020 |
0.389 |
|
| 2017 |
Francelle L, Lotz C, Outeiro T, Brouillet E, Merienne K. Contribution of Neuroepigenetics to Huntington's Disease. Frontiers in Human Neuroscience. 11: 17. PMID 28194101 DOI: 10.3389/Fnhum.2017.00017 |
0.396 |
|
| 2017 |
Pavlou MAS, Pinho R, Paiva I, Outeiro TF. The yin and yang of α-synuclein-associated epigenetics in Parkinson's disease. Brain : a Journal of Neurology. 140: 878-886. PMID 27585855 DOI: 10.1093/Brain/Aww227 |
0.469 |
|
| 2017 |
Outeiro TF. Green Fluorescent Protein Labeling of Dopaminergic Neurons in Zebrafish for the Study of Parkinson’s Diseases Journal of Microbiology & Experimentation. 4. DOI: 10.15406/Jmen.2017.04.00101 |
0.336 |
|
| 2017 |
Macedo D, Bertolin TE, Oro T, Backes LTH, Brás IC, Santos CN, Tenreiro S, Outeiro TF. Phycocyanin protects against Alpha-Synuclein toxicity in yeast Journal of Functional Foods. 38: 553-560. DOI: 10.1016/J.Jff.2017.09.044 |
0.49 |
|
| 2016 |
Lázaro DF, Dias MC, Carija A, Navarro S, Madaleno CS, Tenreiro S, Ventura S, Outeiro TF. The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation. Acta Neuropathologica Communications. 4: 128. PMID 27938414 DOI: 10.1186/S40478-016-0402-8 |
0.477 |
|
| 2016 |
Fernandes JT, Chutna O, Chu V, Conde JP, Outeiro TF. A Novel Microfluidic Cell Co-culture Platform for the Study of the Molecular Mechanisms of Parkinson's Disease and Other Synucleinopathies. Frontiers in Neuroscience. 10: 511. PMID 27895548 DOI: 10.3389/Fnins.2016.00511 |
0.434 |
|
| 2016 |
Vicente Miranda H, Gomes MA, Branco-Santos J, Breda C, Lázaro DF, Lopes LV, Herrera F, Giorgini F, Outeiro TF. Glycation potentiates neurodegeneration in models of Huntington's disease. Scientific Reports. 6: 36798. PMID 27857176 DOI: 10.1038/Srep36798 |
0.491 |
|
| 2016 |
Villar-Piqué A, Lopes da Fonseca T, Sant'Anna R, Szegö ÉM, Fonseca-Ornelas L, Pinho R, Carija A, Gerhardt E, Masaracchia C, Abad Gonzalez E, Rossetti G, Carloni P, Fernández CO, Foguel D, Milosevic I, ... ... Outeiro TF, et al. Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity. Proceedings of the National Academy of Sciences of the United States of America. PMID 27708160 DOI: 10.1073/Pnas.1606791113 |
0.434 |
|
| 2016 |
Guerreiro PS, Coelho JE, Sousa-Lima I, Macedo P, Lopes LV, Outeiro TF, Pais TF. Mutant A53T α-Synuclein Improves Rotarod Performance Before Motor Deficits and Affects Metabolic Pathways. Neuromolecular Medicine. PMID 27535567 DOI: 10.1007/S12017-016-8435-5 |
0.366 |
|
| 2016 |
Batalha VL, Ferreira DG, Coelho JE, Valadas JS, Gomes R, Temido-Ferreira M, Shmidt T, Baqi Y, Buée L, Müller CE, Hamdane M, Outeiro TF, Bader M, Meijsing SH, Sadri-Vakili G, et al. The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function. Scientific Reports. 6: 31493. PMID 27510168 DOI: 10.1038/Srep31493 |
0.301 |
|
| 2016 |
Letra-Vilela R, Sánchez-Sánchez AM, Rocha AM, Martin V, Branco-Santos J, Puente-Moncada N, Santa-Marta M, Outeiro TF, Antolín I, Rodriguez C, Herrera F. Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin. Molecular and Cellular Endocrinology. PMID 27402602 DOI: 10.1016/J.Mce.2016.07.012 |
0.314 |
|
| 2016 |
Kleinknecht A, Popova B, Lázaro DF, Pinho R, Valerius O, Outeiro TF, Braus GH. C-Terminal Tyrosine Residue Modifications Modulate the Protective Phosphorylation of Serine 129 of α-Synuclein in a Yeast Model of Parkinson's Disease. Plos Genetics. 12: e1006098. PMID 27341336 DOI: 10.1371/Journal.Pgen.1006098 |
0.428 |
|
| 2016 |
Gonçalves SA, Outeiro TF. Traffic jams and the complex role of α-Synuclein aggregation in Parkinson disease. Small Gtpases. 8: 78-84. PMID 27314512 DOI: 10.1080/21541248.2016.1199191 |
0.528 |
|
| 2016 |
Lopes da Fonseca T, Pinho R, Outeiro TF. A familial ATP13A2 mutation enhances alpha-synuclein aggregation and promotes cell death. Human Molecular Genetics. PMID 27282395 DOI: 10.1093/Hmg/Ddw147 |
0.523 |
|
| 2016 |
Gonçalves SA, Macedo D, Raquel H, Simões PD, Giorgini F, Ramalho JS, Barral DC, Ferreira Moita L, Outeiro TF. shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity. Plos Genetics. 12: e1005995. PMID 27123591 DOI: 10.1371/Journal.Pgen.1005995 |
0.493 |
|
| 2016 |
Tatenhorst L, Eckermann K, Dambeck V, Fonseca-Ornelas L, Walle H, Lopes da Fonseca T, Koch JC, Becker S, Tönges L, Bähr M, Outeiro TF, Zweckstetter M, Lingor P. Fasudil attenuates aggregation of α-synuclein in models of Parkinson's disease. Acta Neuropathologica Communications. 4: 39. PMID 27101974 DOI: 10.1186/S40478-016-0310-Y |
0.46 |
|
| 2016 |
Gustafsson G, Eriksson F, Möller C, da Fonseca TL, Outeiro TF, Lannfelt L, Bergström J, Ingelsson M. Cellular Uptake of α-Synuclein Oligomer-Selective Antibodies is Enhanced by the Extracellular Presence of α-Synuclein and Mediated via Fcγ Receptors. Cellular and Molecular Neurobiology. PMID 26961542 DOI: 10.1007/S10571-016-0352-5 |
0.434 |
|
| 2016 |
Vicente Miranda H, El-Agnaf OM, Outeiro TF. Glycation in Parkinson's disease and Alzheimer's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 31: 782-90. PMID 26946341 DOI: 10.1002/Mds.26566 |
0.473 |
|
| 2016 |
Oliveira AO, Osmand A, Outeiro TF, Muchowski PJ, Finkbeiner S. αB-Crystallin over-expression in astrocytes modulates the phenotype of the BACHD mouse model of Huntington's disease. Human Molecular Genetics. PMID 26920069 DOI: 10.1093/Hmg/Ddw028 |
0.447 |
|
| 2016 |
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Outeiro TF, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356 |
0.31 |
|
| 2016 |
Outeiro TF, Miranda HV. B7 Glycation potentiates neurodegeneration in models of huntington’s disease Journal of Neurology, Neurosurgery & Psychiatry. 87: A11.2-A11. DOI: 10.1136/Jnnp-2016-314597.38 |
0.313 |
|
| 2015 |
Menezes R, Tenreiro S, Macedo D, Santos CN, Outeiro TF. From the baker to the bedside: yeast models of Parkinson's disease. Microbial Cell (Graz, Austria). 2: 262-279. PMID 28357302 DOI: 10.15698/Mic2015.08.219 |
0.474 |
|
| 2015 |
Oliveira LM, Falomir-Lockhart LJ, Botelho MG, Lin KH, Wales P, Koch JC, Gerhardt E, Taschenberger H, Outeiro TF, Lingor P, Schüle B, Arndt-Jovin DJ, Jovin TM. Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells. Cell Death & Disease. 6: e1994. PMID 26610207 DOI: 10.1038/Cddis.2015.318 |
0.391 |
|
| 2015 |
Tenreiro S, Rosado-Ramos R, Gerhardt E, Favretto F, Magalhães F, Popova B, Becker S, Zweckstetter M, Braus GH, Outeiro TF. Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity. Human Molecular Genetics. PMID 26586132 DOI: 10.1093/Hmg/Ddv470 |
0.482 |
|
| 2015 |
Ferreira DG, Batalha VL, Vicente Miranda H, Coelho JE, Gomes R, Gonçalves FQ, Real JI, Rino J, Albino-Teixeira A, Cunha RA, Outeiro TF, Lopes LV. Adenosine A2A Receptors Modulate α-Synuclein Aggregation and Toxicity. Cerebral Cortex (New York, N.Y. : 1991). PMID 26534909 DOI: 10.1093/Cercor/Bhv268 |
0.448 |
|
| 2015 |
Moree B, Yin G, Lázaro DF, Munari F, Strohäker T, Giller K, Becker S, Outeiro TF, Zweckstetter M, Salafsky J. Small Molecules Detected by Second-Harmonic Generation Modulate the Conformation of Monomeric α-Synuclein and Reduce its Aggregation in Cells. The Journal of Biological Chemistry. PMID 26396193 DOI: 10.1074/Jbc.M114.636027 |
0.465 |
|
| 2015 |
Dučić T, Carboni E, Lai B, Chen S, Michalke B, Lázaro DF, Outeiro TF, Bähr M, Barski E, Lingor P. Alpha-Synuclein Regulates Neuronal Levels of Manganese and Calcium. Acs Chemical Neuroscience. PMID 26284970 DOI: 10.1021/Acschemneuro.5B00093 |
0.374 |
|
| 2015 |
Villar-Piqué A, da Fonseca TL, Outeiro TF. Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies. Journal of Neurochemistry. PMID 26190401 DOI: 10.1111/Jnc.13249 |
0.466 |
|
| 2015 |
Guerreiro PS, Gerhardt E, Lopes da Fonseca T, Bähr M, Outeiro TF, Eckermann K. LRRK2 Promotes Tau Accumulation, Aggregation and Release. Molecular Neurobiology. PMID 26014385 DOI: 10.1007/S12035-015-9209-Z |
0.443 |
|
| 2015 |
Mbefo MK, Fares MB, Paleologou K, Oueslati A, Yin G, Tenreiro S, Pinto M, Outeiro T, Zweckstetter M, Masliah E, Lashuel HA. Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo. The Journal of Biological Chemistry. 290: 9412-27. PMID 25657004 DOI: 10.1074/Jbc.M114.610774 |
0.415 |
|
| 2015 |
Chen X, Wales P, Quinti L, Zuo F, Moniot S, Herisson F, Rauf NA, Wang H, Silverman RB, Ayata C, Maxwell MM, Steegborn C, Schwarzschild MA, Outeiro TF, Kazantsev AG. The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia. Plos One. 10: e0116919. PMID 25608039 DOI: 10.1371/Journal.Pone.0116919 |
0.44 |
|
| 2015 |
Poças GM, Branco-Santos J, Herrera F, Outeiro TF, Domingos PM. α-Synuclein modifies mutant huntingtin aggregation and neurotoxicity in Drosophila. Human Molecular Genetics. 24: 1898-907. PMID 25452431 DOI: 10.1093/Hmg/Ddu606 |
0.507 |
|
| 2015 |
Macedo D, Tavares L, McDougall GJ, Vicente Miranda H, Stewart D, Ferreira RB, Tenreiro S, Outeiro TF, Santos CN. (Poly)phenols protect from α-synuclein toxicity by reducing oxidative stress and promoting autophagy. Human Molecular Genetics. 24: 1717-32. PMID 25432533 DOI: 10.1093/Hmg/Ddu585 |
0.429 |
|
| 2015 |
Breda C, Nugent ML, Estranero JG, Kyriacou CP, Outeiro TF, Steinert JR, Giorgini F. Rab11 modulates α-synuclein-mediated defects in synaptic transmission and behaviour. Human Molecular Genetics. 24: 1077-91. PMID 25305083 DOI: 10.1093/Hmg/Ddu521 |
0.445 |
|
| 2015 |
Blum D, Herrera F, Francelle L, Mendes T, Basquin M, Obriot H, Demeyer D, Sergeant N, Gerhardt E, Brouillet E, Buée L, Outeiro TF. Mutant huntingtin alters Tau phosphorylation and subcellular distribution. Human Molecular Genetics. 24: 76-85. PMID 25143394 DOI: 10.1093/Hmg/Ddu421 |
0.369 |
|
| 2015 |
Amen T, Lázaro DF, Outeiro TF, Kaganovich D. Modeling Neuronal Pathology in Yeast: Insights into the Molecular Basis of Parkinson's Disease Israel Journal of Chemistry. 55: 1252-1259. DOI: 10.1002/Ijch.201500071 |
0.383 |
|
| 2014 |
Lopes da Fonseca T, Outeiro TF. ATP13A2 and Alpha-synuclein: a Metal Taste in Autophagy. Experimental Neurobiology. 23: 314-23. PMID 25548531 DOI: 10.5607/En.2014.23.4.314 |
0.476 |
|
| 2014 |
Fonseca-Ornelas L, Eisbach SE, Paulat M, Giller K, Fernández CO, Outeiro TF, Becker S, Zweckstetter M. Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic misfolding and aggregation. Nature Communications. 5: 5857. PMID 25524885 DOI: 10.1038/Ncomms6857 |
0.404 |
|
| 2014 |
Poehler AM, Xiang W, Spitzer P, May VE, Meixner H, Rockenstein E, Chutna O, Outeiro TF, Winkler J, Masliah E, Klucken J. Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment. Autophagy. 10: 2171-92. PMID 25484190 DOI: 10.4161/Auto.36436 |
0.432 |
|
| 2014 |
Lázaro DF, Rodrigues EF, Langohr R, Shahpasandzadeh H, Ribeiro T, Guerreiro P, Gerhardt E, Kröhnert K, Klucken J, Pereira MD, Popova B, Kruse N, Mollenhauer B, Rizzoli SO, Braus GH, ... ... Outeiro TF, et al. Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation. Plos Genetics. 10: e1004741. PMID 25393002 DOI: 10.1371/Journal.Pgen.1004741 |
0.501 |
|
| 2014 |
Shahpasandzadeh H, Popova B, Kleinknecht A, Fraser PE, Outeiro TF, Braus GH. Interplay between sumoylation and phosphorylation for protection against α-synuclein inclusions. The Journal of Biological Chemistry. 289: 31224-40. PMID 25231978 DOI: 10.1074/Jbc.M114.559237 |
0.441 |
|
| 2014 |
Fernandes JT, Tenreiro S, Gameiro A, Chu V, Outeiro TF, Conde JP. Modulation of alpha-synuclein toxicity in yeast using a novel microfluidic-based gradient generator. Lab On a Chip. 14: 3949-57. PMID 25167219 DOI: 10.1039/C4Lc00756E |
0.467 |
|
| 2014 |
Perfeito R, Lázaro DF, Outeiro TF, Rego AC. Linking alpha-synuclein phosphorylation to reactive oxygen species formation and mitochondrial dysfunction in SH-SY5Y cells. Molecular and Cellular Neurosciences. 62: 51-9. PMID 25109238 DOI: 10.1016/J.Mcn.2014.08.002 |
0.438 |
|
| 2014 |
Chutna O, Gonçalves S, Villar-Piqué A, Guerreiro P, Marijanovic Z, Mendes T, Ramalho J, Emmanouilidou E, Ventura S, Klucken J, Barral DC, Giorgini F, Vekrellis K, Outeiro TF. The small GTPase Rab11 co-localizes with α-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity. Human Molecular Genetics. 23: 6732-45. PMID 25092884 DOI: 10.1093/Hmg/Ddu391 |
0.512 |
|
| 2014 |
Zondler L, Miller-Fleming L, Repici M, Gonçalves S, Tenreiro S, Rosado-Ramos R, Betzer C, Straatman KR, Jensen PH, Giorgini F, Outeiro TF. DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease. Cell Death & Disease. 5: e1350. PMID 25058424 DOI: 10.1038/Cddis.2014.307 |
0.477 |
|
| 2014 |
Yin G, Lopes da Fonseca T, Eisbach SE, Anduaga AM, Breda C, Orcellet ML, Szeg? ÉM, Guerreiro P, Lázaro DF, Braus GH, Fernandez CO, Griesinger C, Becker S, Goody RS, Itzen A, ... ... Outeiro TF, et al. α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner. Neurobiology of Disease. 70: 149-61. PMID 24983211 DOI: 10.1016/J.Nbd.2014.06.018 |
0.454 |
|
| 2014 |
Tenreiro S, Eckermann K, Outeiro TF. Protein phosphorylation in neurodegeneration: friend or foe? Frontiers in Molecular Neuroscience. 7: 42. PMID 24860424 DOI: 10.3389/Fnmol.2014.00042 |
0.488 |
|
| 2014 |
Tenreiro S, Reimão-Pinto MM, Antas P, Rino J, Wawrzycka D, Macedo D, Rosado-Ramos R, Amen T, Waiss M, Magalhães F, Gomes A, Santos CN, Kaganovich D, Outeiro TF. Phosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson's disease. Plos Genetics. 10: e1004302. PMID 24810576 DOI: 10.1371/Journal.Pgen.1004302 |
0.493 |
|
| 2014 |
Miller-Fleming L, Antas P, Pais TF, Smalley JL, Giorgini F, Outeiro TF. Yeast DJ-1 superfamily members are required for diauxic-shift reprogramming and cell survival in stationary phase. Proceedings of the National Academy of Sciences of the United States of America. 111: 7012-7. PMID 24706893 DOI: 10.1073/Pnas.1319221111 |
0.371 |
|
| 2014 |
Rodrigues TM, Jerónimo-Santos A, Outeiro TF, Sebastião AM, Diógenes MJ. Challenges and promises in the development of neurotrophic factor-based therapies for Parkinson's disease. Drugs & Aging. 31: 239-61. PMID 24610720 DOI: 10.1007/S40266-014-0160-X |
0.439 |
|
| 2014 |
Vittori A, Breda C, Repici M, Orth M, Roos RA, Outeiro TF, Giorgini F, Hollox EJ. Copy-number variation of the neuronal glucose transporter gene SLC2A3 and age of onset in Huntington's disease. Human Molecular Genetics. 23: 3129-37. PMID 24452335 DOI: 10.1093/Hmg/Ddu022 |
0.359 |
|
| 2014 |
McFarland KN, Huizenga MN, Darnell SB, Sangrey GR, Berezovska O, Cha JH, Outeiro TF, Sadri-Vakili G. MeCP2: a novel Huntingtin interactor. Human Molecular Genetics. 23: 1036-44. PMID 24105466 DOI: 10.1093/Hmg/Ddt499 |
0.36 |
|
| 2014 |
Sajjad MU, Green EW, Miller-Fleming L, Hands S, Herrera F, Campesan S, Khoshnan A, Outeiro TF, Giorgini F, Wyttenbach A. DJ-1 modulates aggregation and pathogenesis in models of Huntington's disease. Human Molecular Genetics. 23: 755-66. PMID 24070869 DOI: 10.1093/Hmg/Ddt466 |
0.455 |
|
| 2014 |
Miranda H, Gomes M, Branco dos Santos J, Giorgini F, Outeiro T. B08 Glycation Modulates Huntingtin Aggregation And Toxicity Journal of Neurology, Neurosurgery & Psychiatry. 85: A11-A11. DOI: 10.1136/Jnnp-2014-309032.36 |
0.471 |
|
| 2014 |
Branco dos Santos J, Staniforth G, Breda C, Herrera F, Outeiro T, Tuite M, Giorgini F. B07 Aggregation-prone Proteins Exacerbate Huntingtin Toxicity In Yeast And Drosophila Journal of Neurology, Neurosurgery & Psychiatry. 85: A11-A11. DOI: 10.1136/Jnnp-2014-309032.35 |
0.432 |
|
| 2014 |
Branco dos Santos J, Herrera F, Giorgini F, Outeiro T. B06 Exploring The Role Of Phosphorylation In Huntingtin Aggregation Dynamics Journal of Neurology, Neurosurgery & Psychiatry. 85: A11-A11. DOI: 10.1136/Jnnp-2014-309032.34 |
0.449 |
|
| 2014 |
Fernandes JTS, Tenreiro S, Pedrosa CR, Gameiro A, Chu V, Outeiro TF, Conde JP. Integration of single cell traps, chemical gradient generator and photosensors in a microfluidic platform for the study of alphasynuclein toxicity in yeast Procedia Engineering. 87: 92-95. DOI: 10.1016/J.Proeng.2014.11.273 |
0.369 |
|
| 2013 |
Vittori A, Orth M, Roos RA, Outeiro TF, Giorgini F, Hollox EJ. β-Defensin Genomic Copy Number Does Not Influence the Age of Onset in Huntington's Disease. Journal of Huntington's Disease. 2: 107-124. PMID 24587836 DOI: 10.3233/Jhd-130047 |
0.335 |
|
| 2013 |
Wales P, Pinho R, Lázaro DF, Outeiro TF. Limelight on alpha-synuclein: pathological and mechanistic implications in neurodegeneration. Journal of Parkinson's Disease. 3: 415-59. PMID 24270242 DOI: 10.3233/Jpd-130216 |
0.485 |
|
| 2013 |
Fagerqvist T, Näsström T, Ihse E, Lindström V, Sahlin C, Tucker SM, Kasaryan A, Karlsson M, Nikolajeff F, Schell H, Outeiro TF, Kahle PJ, Lannfelt L, Ingelsson M, Bergström J. Off-pathway α-synuclein oligomers seem to alter α-synuclein turnover in a cell model but lack seeding capability in vivo. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 20: 233-44. PMID 24053224 DOI: 10.3109/13506129.2013.835726 |
0.474 |
|
| 2013 |
Basso E, Antas P, Marijanovic Z, Gonçalves S, Tenreiro S, Outeiro TF. PLK2 modulates α-synuclein aggregation in yeast and mammalian cells. Molecular Neurobiology. 48: 854-62. PMID 23677647 DOI: 10.1007/S12035-013-8473-Z |
0.384 |
|
| 2013 |
Amaral M, Outeiro TF, Scrutton NS, Giorgini F. The causative role and therapeutic potential of the kynurenine pathway in neurodegenerative disease. Journal of Molecular Medicine (Berlin, Germany). 91: 705-13. PMID 23636512 DOI: 10.1007/S00109-013-1046-9 |
0.363 |
|
| 2013 |
Eisbach SE, Outeiro TF. Alpha-synuclein and intracellular trafficking: impact on the spreading of Parkinson's disease pathology. Journal of Molecular Medicine (Berlin, Germany). 91: 693-703. PMID 23616088 DOI: 10.1007/S00109-013-1038-9 |
0.501 |
|
| 2013 |
Faria C, Jorge CD, Borges N, Tenreiro S, Outeiro TF, Santos H. Inhibition of formation of α-synuclein inclusions by mannosylglycerate in a yeast model of Parkinson's disease. Biochimica Et Biophysica Acta. 1830: 4065-72. PMID 23608058 DOI: 10.1016/J.Bbagen.2013.04.015 |
0.437 |
|
| 2013 |
Tenreiro S, Munder MC, Alberti S, Outeiro TF. Harnessing the power of yeast to unravel the molecular basis of neurodegeneration. Journal of Neurochemistry. 127: 438-52. PMID 23600759 DOI: 10.1111/Jnc.12271 |
0.486 |
|
| 2013 |
Amaral M, Levy C, Heyes DJ, Lafite P, Outeiro TF, Giorgini F, Leys D, Scrutton NS. Structural basis of kynurenine 3-monooxygenase inhibition. Nature. 496: 382-5. PMID 23575632 DOI: 10.1038/Nature12039 |
0.385 |
|
| 2013 |
Taschenberger G, Toloe J, Tereshchenko J, Akerboom J, Wales P, Benz R, Becker S, Outeiro TF, Looger LL, Bähr M, Zweckstetter M, Kügler S. β-synuclein aggregates and induces neurodegeneration in dopaminergic neurons. Annals of Neurology. 74: 109-18. PMID 23536356 DOI: 10.1002/Ana.23905 |
0.486 |
|
| 2013 |
Vicente Miranda H, Xiang W, de Oliveira RM, Simões T, Pimentel J, Klucken J, Penque D, Outeiro TF. Heat-mediated enrichment of α-synuclein from cells and tissue for assessing post-translational modifications. Journal of Neurochemistry. 126: 673-84. PMID 23534813 DOI: 10.1111/Jnc.12251 |
0.441 |
|
| 2013 |
Schildknecht S, Gerding HR, Karreman C, Drescher M, Lashuel HA, Outeiro TF, Di Monte DA, Leist M. Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies. Journal of Neurochemistry. 125: 491-511. PMID 23452040 DOI: 10.1111/Jnc.12226 |
0.488 |
|
| 2013 |
Donmez G, Outeiro TF. SIRT1 and SIRT2: emerging targets in neurodegeneration. Embo Molecular Medicine. 5: 344-52. PMID 23417962 DOI: 10.1002/Emmm.201302451 |
0.462 |
|
| 2013 |
Gonçalves S, Outeiro TF. Assessing the subcellular dynamics of alpha-synuclein using photoactivation microscopy. Molecular Neurobiology. 47: 1081-92. PMID 23389286 DOI: 10.1007/S12035-013-8406-X |
0.414 |
|
| 2013 |
Guerreiro PS, Huang Y, Gysbers A, Cheng D, Gai WP, Outeiro TF, Halliday GM. LRRK2 interactions with α-synuclein in Parkinson's disease brains and in cell models. Journal of Molecular Medicine (Berlin, Germany). 91: 513-22. PMID 23183827 DOI: 10.1007/S00109-012-0984-Y |
0.481 |
|
| 2013 |
Repici M, Straatman KR, Balduccio N, Enguita FJ, Outeiro TF, Giorgini F. Parkinson's disease-associated mutations in DJ-1 modulate its dimerization in living cells. Journal of Molecular Medicine (Berlin, Germany). 91: 599-611. PMID 23183826 DOI: 10.1007/S00109-012-0976-Y |
0.397 |
|
| 2013 |
Marques S, Outeiro TF. Epigenetics in Parkinson's and Alzheimer's diseases. Sub-Cellular Biochemistry. 61: 507-25. PMID 23150265 DOI: 10.1007/978-94-007-4525-4_22 |
0.411 |
|
| 2013 |
Lopes da Fonseca T, Correia A, Hasselaar W, van der Linde HC, Willemsen R, Outeiro TF. The zebrafish homologue of Parkinson's disease ATP13A2 is essential for embryonic survival. Brain Research Bulletin. 90: 118-26. PMID 23123961 DOI: 10.1016/J.Brainresbull.2012.09.017 |
0.435 |
|
| 2013 |
Szeg? ÉM, Outeiro TF, Kermer P, Schulz JB. Impairment of the septal cholinergic neurons in MPTP-treated A30P α-synuclein mice. Neurobiology of Aging. 34: 589-601. PMID 22579457 DOI: 10.1016/J.Neurobiolaging.2012.04.012 |
0.331 |
|
| 2013 |
Ingelsson M, Fagerqvist T, Näsström T, Ihse E, Lindström V, Sahlin C, Tucker S, Kasrayan A, Karlsson M, Nikolajeff F, Nath S, Agholme L, Outeiro T, Hallbeck M, Lannfelt L, et al. Alpha-synuclein oligomers can act as seed in a fibrillation assay but do not cause increased aggregation in living cells Alzheimers & Dementia. 9: 721. DOI: 10.1016/J.Jalz.2013.05.1442 |
0.394 |
|
| 2012 |
Diógenes MJ, Dias RB, Rombo DM, Vicente Miranda H, Maiolino F, Guerreiro P, Näsström T, Franquelim HG, Oliveira LM, Castanho MA, Lannfelt L, Bergström J, Ingelsson M, Quintas A, Sebastião AM, ... ... Outeiro TF, et al. Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 11750-62. PMID 22915117 DOI: 10.1523/Jneurosci.0234-12.2012 |
0.388 |
|
| 2012 |
Sampaio-Marques B, Felgueiras C, Silva A, Rodrigues M, Tenreiro S, Franssens V, Reichert AS, Outeiro TF, Winderickx J, Ludovico P. SNCA (α-synuclein)-induced toxicity in yeast cells is dependent on sirtuin 2 (Sir2)-mediated mitophagy. Autophagy. 8: 1494-509. PMID 22914317 DOI: 10.4161/Auto.21275 |
0.47 |
|
| 2012 |
Marques O, Outeiro TF. Alpha-synuclein: from secretion to dysfunction and death. Cell Death & Disease. 3: e350. PMID 22825468 DOI: 10.1038/Cddis.2012.94 |
0.46 |
|
| 2012 |
Petroi D, Popova B, Taheri-Talesh N, Irniger S, Shahpasandzadeh H, Zweckstetter M, Outeiro TF, Braus GH. Aggregate clearance of α-synuclein in Saccharomyces cerevisiae depends more on autophagosome and vacuole function than on the proteasome. The Journal of Biological Chemistry. 287: 27567-79. PMID 22722939 DOI: 10.1074/jbc.M112.361865 |
0.37 |
|
| 2012 |
Rosa P, Tenreiro S, Chu V, Outeiro TF, Conde JP. High-throughput study of alpha-synuclein expression in yeast using microfluidics for control of local cellular microenvironment. Biomicrofluidics. 6: 14109-141099. PMID 22662094 DOI: 10.1063/1.3683161 |
0.363 |
|
| 2012 |
de Oliveira RM, Sarkander J, Kazantsev AG, Outeiro TF. SIRT2 as a Therapeutic Target for Age-Related Disorders. Frontiers in Pharmacology. 3: 82. PMID 22563317 DOI: 10.3389/Fphar.2012.00082 |
0.361 |
|
| 2012 |
Kazantsev AG, Outeiro TF. Editorial on special topic: sirtuins in metabolism, aging, and disease. Frontiers in Pharmacology. 3: 71. PMID 22536186 DOI: 10.3389/Fphar.2012.00071 |
0.378 |
|
| 2012 |
Sancenon V, Lee SA, Patrick C, Griffith J, Paulino A, Outeiro TF, Reggiori F, Masliah E, Muchowski PJ. Suppression of α-synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context. Human Molecular Genetics. 21: 2432-49. PMID 22357655 DOI: 10.1093/Hmg/Dds058 |
0.42 |
|
| 2012 |
Herrera F, Gonçalves S, Outeiro TF. Imaging protein oligomerization in neurodegeneration using bimolecular fluorescence complementation. Methods in Enzymology. 506: 157-74. PMID 22341224 DOI: 10.1016/B978-0-12-391856-7.00033-0 |
0.448 |
|
| 2012 |
Kemppainen S, Rantamäki T, Jerónimo-Santos A, Lavasseur G, Autio H, Karpova N, Kärkkäinen E, Stavén S, Vicente Miranda H, Outeiro TF, Diógenes MJ, Laroche S, Davis S, Sebastião AM, Castrén E, et al. Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice. Neurobiology of Aging. 33: 1122.e23-39. PMID 22209410 DOI: 10.1016/J.Neurobiolaging.2011.11.006 |
0.302 |
|
| 2012 |
Herrera F, Outeiro TF. α-Synuclein modifies huntingtin aggregation in living cells. Febs Letters. 586: 7-12. PMID 22119730 DOI: 10.1016/J.Febslet.2011.11.019 |
0.474 |
|
| 2012 |
Gonçalves S, Miranda HV, Outeiro TF. Novel Molecular Therapeutics in Parkinson's Disease Molecular and Cellular Therapeutics. 245-265. DOI: 10.1002/9781119967309.ch11 |
0.306 |
|
| 2011 |
Gerhardt E, Gräber S, Szego EM, Moisoi N, Martins LM, Outeiro TF, Kermer P. Idebenone and resveratrol extend lifespan and improve motor function of HtrA2 knockout mice. Plos One. 6: e28855. PMID 22205977 DOI: 10.1371/Journal.Pone.0028855 |
0.4 |
|
| 2011 |
Ribeiro Morais G, Vicente Miranda H, Santos IC, Santos I, Outeiro TF, Paulo A. Synthesis and in vitro evaluation of fluorinated styryl benzazoles as amyloid-probes. Bioorganic & Medicinal Chemistry. 19: 7698-710. PMID 22078413 DOI: 10.1016/J.Bmc.2011.09.065 |
0.365 |
|
| 2011 |
Näsström T, Gonçalves S, Sahlin C, Nordström E, Screpanti Sundquist V, Lannfelt L, Bergström J, Outeiro TF, Ingelsson M. Antibodies against alpha-synuclein reduce oligomerization in living cells. Plos One. 6: e27230. PMID 22073131 DOI: 10.1371/Journal.Pone.0027230 |
0.395 |
|
| 2011 |
Badiola N, de Oliveira RM, Herrera F, Guardia-Laguarta C, Gonçalves SA, Pera M, Suárez-Calvet M, Clarimon J, Outeiro TF, Lleó A. Tau enhances α-synuclein aggregation and toxicity in cellular models of synucleinopathy. Plos One. 6: e26609. PMID 22039514 DOI: 10.1371/Journal.Pone.0026609 |
0.466 |
|
| 2011 |
Martins M, Rosa A, Guedes LC, Fonseca BV, Gotovac K, Violante S, Mestre T, Coelho M, Rosa MM, Martin ER, Vance JM, Outeiro TF, Wang L, Borovecki F, Ferreira JJ, et al. Convergence of miRNA expression profiling, α-synuclein interacton and GWAS in Parkinson's disease. Plos One. 6: e25443. PMID 22003392 DOI: 10.1371/Journal.Pone.0025443 |
0.375 |
|
| 2011 |
Swinnen E, Büttner S, Outeiro TF, Galas MC, Madeo F, Winderickx J, Franssens V. Aggresome formation and segregation of inclusions influence toxicity of α-synuclein and synphilin-1 in yeast. Biochemical Society Transactions. 39: 1476-81. PMID 21936837 DOI: 10.1042/Bst0391476 |
0.49 |
|
| 2011 |
Outeiro TF. Amyloidogenesis: FlAsH illuminates Aβ aggregation. Nature Chemical Biology. 7: 581-2. PMID 21849997 DOI: 10.1038/Nchembio.636 |
0.42 |
|
| 2011 |
Szego ÉM, Gerhardt E, Outeiro TF, Kermer P. Dopamine-depletion and increased α-synuclein load induce degeneration of cortical cholinergic fibers in mice. Journal of the Neurological Sciences. 310: 90-5. PMID 21774947 DOI: 10.1016/J.Jns.2011.06.048 |
0.341 |
|
| 2011 |
de Oliveira RM, Marijanovic Z, Carvalho F, Miltényi GM, Matos JE, Tenreiro S, Oliveira S, Enguita FJ, Stone R, Outeiro TF. Impaired proteostasis contributes to renal tubular dysgenesis. Plos One. 6: e20854. PMID 21695262 DOI: 10.1371/Journal.Pone.0020854 |
0.307 |
|
| 2011 |
Marques S, Batalha VL, Lopes LV, Outeiro TF. Modulating Alzheimer's disease through caffeine: a putative link to epigenetics. Journal of Alzheimer's Disease : Jad. 24: 161-71. PMID 21427489 DOI: 10.3233/Jad-2011-110032 |
0.347 |
|
| 2011 |
Jorge CD, Ventura R, Maycock C, Outeiro TF, Santos H, Costa J. Assessment of the efficacy of solutes from extremophiles on protein aggregation in cell models of Huntington's and Parkinson's diseases. Neurochemical Research. 36: 1005-11. PMID 21416120 DOI: 10.1007/S11064-011-0440-3 |
0.437 |
|
| 2011 |
Herrera F, Tenreiro S, Miller-Fleming L, Outeiro TF. Visualization of cell-to-cell transmission of mutant huntingtin oligomers. Plos Currents. 3: RRN1210. PMID 21331289 DOI: 10.1371/Currents.Rrn1210 |
0.315 |
|
| 2011 |
Hansen C, Angot E, Bergström AL, Steiner JA, Pieri L, Paul G, Outeiro TF, Melki R, Kallunki P, Fog K, Li JY, Brundin P. α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells. The Journal of Clinical Investigation. 121: 715-25. PMID 21245577 DOI: 10.1172/Jci43366 |
0.414 |
|
| 2011 |
Tauber E, Miller-Fleming L, Mason RP, Kwan W, Clapp J, Butler NJ, Outeiro TF, Muchowski PJ, Giorgini F. Functional gene expression profiling in yeast implicates translational dysfunction in mutant huntingtin toxicity. The Journal of Biological Chemistry. 286: 410-9. PMID 21044956 DOI: 10.1074/Jbc.M110.101527 |
0.369 |
|
| 2011 |
Marques SC, Oliveira CR, Pereira CM, Outeiro TF. Epigenetics in neurodegeneration: a new layer of complexity. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 35: 348-55. PMID 20736041 DOI: 10.1016/J.Pnpbp.2010.08.008 |
0.41 |
|
| 2010 |
Büttner S, Delay C, Franssens V, Bammens T, Ruli D, Zaunschirm S, de Oliveira RM, Outeiro TF, Madeo F, Buée L, Galas MC, Winderickx J. Synphilin-1 enhances α-synuclein aggregation in yeast and contributes to cellular stress and cell death in a Sir2-dependent manner. Plos One. 5: e13700. PMID 21060871 DOI: 10.1371/Journal.Pone.0013700 |
0.38 |
|
| 2010 |
Diógenes MJ, Outeiro TF. Neurotrophic factors as a protective strategy in Parkinson's disease. Cns & Neurological Disorders Drug Targets. 9: 754-63. PMID 20942787 DOI: 10.2174/187152710793237449 |
0.44 |
|
| 2010 |
de Oliveira RM, Pais TF, Outeiro TF. Sirtuins: common targets in aging and in neurodegeneration. Current Drug Targets. 11: 1270-80. PMID 20840069 DOI: 10.2174/1389450111007011270 |
0.362 |
|
| 2010 |
Tenreiro S, Outeiro TF. Simple is good: yeast models of neurodegeneration. Fems Yeast Research. 10: 970-9. PMID 20579105 DOI: 10.1111/J.1567-1364.2010.00649.X |
0.414 |
|
| 2010 |
Gonçalves SA, Matos JE, Outeiro TF. Zooming into protein oligomerization in neurodegeneration using BiFC. Trends in Biochemical Sciences. 35: 643-51. PMID 20561791 DOI: 10.1016/J.Tibs.2010.05.007 |
0.428 |
|
| 2010 |
Marques SC, Oliveira CR, Outeiro TF, Pereira CM. Alzheimer's disease: the quest to understand complexity. Journal of Alzheimer's Disease : Jad. 21: 373-83. PMID 20555132 DOI: 10.3233/Jad-2010-100303 |
0.381 |
|
| 2010 |
Vicente Miranda H, Outeiro TF. The sour side of neurodegenerative disorders: the effects of protein glycation. The Journal of Pathology. 221: 13-25. PMID 20186922 DOI: 10.1002/Path.2682 |
0.429 |
|
| 2010 |
Su LJ, Auluck PK, Outeiro TF, Yeger-Lotem E, Kritzer JA, Tardiff DF, Strathearn KE, Liu F, Cao S, Hamamichi S, Hill KJ, Caldwell KA, Bell GW, Fraenkel E, Cooper AA, et al. Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models. Disease Models & Mechanisms. 3: 194-208. PMID 20038714 DOI: 10.1242/Dmm.004267 |
0.776 |
|
| 2009 |
Outeiro TF, Ferreira J. Current and future therapeutic strategies for Parkinson's disease. Current Pharmaceutical Design. 15: 3968-76. PMID 19751203 DOI: 10.2174/138161209789649321 |
0.481 |
|
| 2009 |
Outeiro TF, Klucken J, Bercury K, Tetzlaff J, Putcha P, Oliveira LM, Quintas A, McLean PJ, Hyman BT. Dopamine-induced conformational changes in alpha-synuclein. Plos One. 4: e6906. PMID 19730729 DOI: 10.1371/Journal.Pone.0006906 |
0.418 |
|
| 2008 |
Outeiro TF, Kazantsev A. Drug Targeting of alpha-Synuclein Oligomerization in Synucleinopathies. Perspectives in Medicinal Chemistry. 2: 41-9. PMID 19787096 |
0.382 |
|
| 2008 |
Mollenhauer B, Cullen V, Kahn I, Krastins B, Outeiro TF, Pepivani I, Ng J, Schulz-Schaeffer W, Kretzschmar HA, McLean PJ, Trenkwalder C, Sarracino DA, Vonsattel JP, Locascio JJ, El-Agnaf OM, et al. Direct quantification of CSF alpha-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration. Experimental Neurology. 213: 315-25. PMID 18625222 DOI: 10.1016/J.Expneurol.2008.06.004 |
0.42 |
|
| 2008 |
Tetzlaff JE, Putcha P, Outeiro TF, Ivanov A, Berezovska O, Hyman BT, McLean PJ. CHIP targets toxic alpha-Synuclein oligomers for degradation. The Journal of Biological Chemistry. 283: 17962-8. PMID 18436529 DOI: 10.1074/Jbc.M802283200 |
0.429 |
|
| 2008 |
Outeiro TF, Putcha P, Tetzlaff JE, Spoelgen R, Koker M, Carvalho F, Hyman BT, McLean PJ. Formation of toxic oligomeric alpha-synuclein species in living cells. Plos One. 3: e1867. PMID 18382657 DOI: 10.1371/Journal.Pone.0001867 |
0.448 |
|
| 2008 |
Fleming J, Outeiro TF, Slack M, Lindquist SL, Bulawa CE. Detection of compounds that rescue Rab1-synuclein toxicity. Methods in Enzymology. 439: 339-51. PMID 18374176 DOI: 10.1016/S0076-6879(07)00425-9 |
0.628 |
|
| 2008 |
Outeiro TF, Marques O, Kazantsev A. Therapeutic role of sirtuins in neurodegenerative disease. Biochimica Et Biophysica Acta. 1782: 363-9. PMID 18373985 DOI: 10.1016/J.Bbadis.2008.02.010 |
0.427 |
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| 2008 |
Miller-Fleming L, Giorgini F, Outeiro TF. Yeast as a model for studying human neurodegenerative disorders. Biotechnology Journal. 3: 325-38. PMID 18228539 DOI: 10.1002/Biot.200700217 |
0.458 |
|
| 2008 |
Outeiro TF, Putcha P, Tetzlaff JE, Spoelgen R, Koker M, Carvalho F, Hyman BT, McLean PJ. Correction: Formation of Toxic Oligomeric α-Synuclein Species in Living Cells Plos One. 3. DOI: 10.1371/Annotation/9282F173-Df82-4B70-9120-B4E62B3Dacb1 |
0.33 |
|
| 2007 |
Grammatopoulos TN, Outeiro TF, Hyman BT, Standaert DG. Angiotensin II protects against alpha-synuclein toxicity and reduces protein aggregation in vitro. Biochemical and Biophysical Research Communications. 363: 846-51. PMID 17900533 DOI: 10.1016/J.Bbrc.2007.09.043 |
0.441 |
|
| 2007 |
Outeiro TF, Kontopoulos E, Altmann SM, Kufareva I, Strathearn KE, Amore AM, Volk CB, Maxwell MM, Rochet JC, McLean PJ, Young AB, Abagyan R, Feany MB, Hyman BT, Kazantsev AG. Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science (New York, N.Y.). 317: 516-9. PMID 17588900 DOI: 10.1126/Science.1143780 |
0.478 |
|
| 2007 |
Outeiro TF, Grammatopoulos TN, Altmann S, Amore A, Standaert DG, Hyman BT, Kazantsev AG. Pharmacological inhibition of PARP-1 reduces alpha-synuclein- and MPP+-induced cytotoxicity in Parkinson's disease in vitro models. Biochemical and Biophysical Research Communications. 357: 596-602. PMID 17449015 DOI: 10.1016/J.Bbrc.2007.03.163 |
0.467 |
|
| 2007 |
Outeiro TF, Tetzlaff J. Mechanisms of disease II: cellular protein quality control. Seminars in Pediatric Neurology. 14: 15-25. PMID 17331880 DOI: 10.1016/J.Spen.2006.11.005 |
0.447 |
|
| 2007 |
St Martin JL, Klucken J, Outeiro TF, Nguyen P, Keller-McGandy C, Cantuti-Castelvetri I, Grammatopoulos TN, Standaert DG, Hyman BT, McLean PJ. Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra. Journal of Neurochemistry. 100: 1449-57. PMID 17241127 DOI: 10.1111/J.1471-4159.2006.04310.X |
0.465 |
|
| 2007 |
Outeiro TF, McLean PJ, Hyman BT. Protein aggregation disorders Neurobiology of Disease. 111-123. DOI: 10.1016/B978-012088592-3/50012-8 |
0.497 |
|
| 2006 |
Outeiro TF, Klucken J, Strathearn KE, Liu F, Nguyen P, Rochet JC, Hyman BT, McLean PJ. Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation. Biochemical and Biophysical Research Communications. 351: 631-8. PMID 17081499 DOI: 10.1016/J.Bbrc.2006.10.085 |
0.475 |
|
| 2006 |
Klucken J, Outeiro TF, Nguyen P, McLean PJ, Hyman BT. Detection of novel intracellular alpha-synuclein oligomeric species by fluorescence lifetime imaging. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 2050-7. PMID 17012257 DOI: 10.1096/Fj.05-5422Com |
0.403 |
|
| 2006 |
Outeiro TF, Giorgini F. Yeast as a drug discovery platform in Huntington's and Parkinson's diseases. Biotechnology Journal. 1: 258-69. PMID 16897706 DOI: 10.1002/Biot.200500043 |
0.477 |
|
| 2006 |
Bodner RA, Outeiro TF, Altmann S, Maxwell MM, Cho SH, Hyman BT, McLean PJ, Young AB, Housman DE, Kazantsev AG. Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases. Proceedings of the National Academy of Sciences of the United States of America. 103: 4246-51. PMID 16537516 DOI: 10.1073/Pnas.0511256103 |
0.477 |
|
| 2004 |
Derkatch IL, Uptain SM, Outeiro TF, Krishnan R, Lindquist SL, Liebman SW. Effects of Q/N-rich, polyQ, and non-polyQ amyloids on the de novo formation of the [PSI+] prion in yeast and aggregation of Sup35 in vitro. Proceedings of the National Academy of Sciences of the United States of America. 101: 12934-9. PMID 15326312 DOI: 10.1073/Pnas.0404968101 |
0.556 |
|
| 2004 |
Outeiro TF, Muchowski PJ. Molecular genetics approaches in yeast to study amyloid diseases. Journal of Molecular Neuroscience : Mn. 23: 49-60. PMID 15126692 DOI: 10.1385/Jmn:23:1-2:049 |
0.484 |
|
| 2004 |
Rochet JC, Outeiro TF, Conway KA, Ding TT, Volles MJ, Lashuel HA, Bieganski RM, Lindquist SL, Lansbury PT. Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease. Journal of Molecular Neuroscience : Mn. 23: 23-34. PMID 15126689 DOI: 10.1385/Jmn:23:1-2:023 |
0.626 |
|
| 2004 |
Da Cruz E Silva EF, Outeiro TF, Da Cruz E Silva OAB. Symposium on novel therapeutic opportunities for neurodegenerative disease Journal of Molecular Neuroscience. 23: 1-2. DOI: 10.1385/Jmn:23:1-2:001 |
0.391 |
|
| 2003 |
Outeiro TF, Lindquist S. Yeast cells provide insight into alpha-synuclein biology and pathobiology. Science (New York, N.Y.). 302: 1772-5. PMID 14657500 DOI: 10.1126/Science.1090439 |
0.599 |
|
| 2003 |
Willingham S, Outeiro TF, DeVit MJ, Lindquist SL, Muchowski PJ. Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein. Science (New York, N.Y.). 302: 1769-72. PMID 14657499 DOI: 10.1126/Science.1090389 |
0.582 |
|
| 2003 |
Resende CG, Outeiro TF, Sands L, Lindquist S, Tuite MF. Prion protein gene polymorphisms in Saccharomyces cerevisiae. Molecular Microbiology. 49: 1005-17. PMID 12890024 DOI: 10.1046/j.1365-2958.2003.03608.x |
0.434 |
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