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Charles Brenner - Publications

Affiliations: 
University of Iowa, Iowa City, IA 
Area:
metabolism
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89 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Heer CD, Sanderson DJ, Voth LS, Alhammad YMO, Schmidt MS, Trammell SAJ, Perlman S, Cohen MS, Fehr AR, Brenner C. Coronavirus infection and PARP expression dysregulate the NAD Metabolome: an actionable component of innate immunity. The Journal of Biological Chemistry. PMID 33051211 DOI: 10.1074/jbc.RA120.015138  0.643
2020 Nam TS, Park DR, Rah SY, Woo TG, Chung HT, Brenner C, Kim UH. Interleukin-8 drives CD38 to form NAADP from NADP and NAAD in the endolysosomes to mobilize Ca and effect cell migration. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32717131 DOI: 10.1096/Fj.202001249R  0.322
2020 Heer CD, Sanderson DJ, Alhammad YMO, Schmidt MS, Trammell SAJ, Perlman S, Cohen MS, Fehr AR, Brenner C. Coronavirus and PARP expression dysregulate the NAD Metabolome: a potentially actionable component of innate immunity. Biorxiv : the Preprint Server For Biology. PMID 32511303 DOI: 10.1101/2020.04.17.047480  0.608
2020 Levine DC, Hong H, Weidemann BJ, Ramsey KM, Affinati AH, Schmidt MS, Cedernaes J, Omura C, Braun R, Lee C, Brenner C, Peek CB, Bass J. NAD Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging. Molecular Cell. PMID 32369735 DOI: 10.1016/J.Molcel.2020.04.010  0.324
2019 Fons NR, Sundaram RK, Breuer GA, Peng S, McLean RL, Kalathil AN, Schmidt MS, Carvalho DM, Mackay A, Jones C, Carcaboso ÁM, Nazarian J, Berens ME, Brenner C, Bindra RS. PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma. Nature Communications. 10: 3790. PMID 31439867 DOI: 10.1038/S41467-019-11732-6  0.373
2019 Elhassan YS, Kluckova K, Fletcher RS, Schmidt MS, Garten A, Doig CL, Cartwright DM, Oakey L, Burley CV, Jenkinson N, Wilson M, Lucas SJE, Akerman I, Seabright A, Lai YC, ... ... Brenner C, et al. Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. Cell Reports. 28: 1717-1728.e6. PMID 31412242 DOI: 10.1016/J.Celrep.2019.07.043  0.3
2019 Lindsay K, Brenner C, Hockenbery D, Paddison P. CBMT-30. TARGETING NICOTINAMIDE ADENINE DINUCLEOTIDE BIOSYNTHESIS IN CNS TUMORS Neuro-Oncology. 21: vi39-vi39. DOI: 10.1093/Neuonc/Noz175.152  0.368
2018 Liu HW, Smith CB, Schmidt MS, Cambronne XA, Cohen MS, Migaud ME, Brenner C, Goodman RH. Pharmacological bypass of NAD salvage pathway protects neurons from chemotherapy-induced degeneration. Proceedings of the National Academy of Sciences of the United States of America. PMID 30257945 DOI: 10.1073/Pnas.1809392115  0.354
2018 Mitchell SJ, Bernier M, Aon MA, Cortassa S, Kim EY, Fang EF, Palacios HH, Ali A, Navas-Enamorado I, Di Francesco A, Kaiser TA, Waltz TB, Zhang N, Ellis JL, Elliott PJ, ... ... Brenner C, et al. Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice. Cell Metabolism. 27: 667-676.e4. PMID 29514072 DOI: 10.1016/J.Cmet.2018.02.001  0.312
2017 Matasic DS, Brenner C, London B. Emerging Potential Benefits of Modulating NAD+ Metabolism in Cardiovascular Disease. American Journal of Physiology. Heart and Circulatory Physiology. PMID 29351465 DOI: 10.1152/Ajpheart.00409.2017  0.353
2017 Diguet N, Trammell SAJ, Tannous C, Deloux R, Piquereau J, Mougenot N, Gouge A, Gressette M, Manoury B, Blanc J, Breton M, Decaux JF, Lavery G, Baczkó I, Zoll J, ... ... Brenner C, et al. Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy. Circulation. PMID 29217642 DOI: 10.1161/Circulationaha.116.026099  0.648
2017 Sato S, Solanas G, Peixoto FO, Bee L, Symeonidi A, Schmidt MS, Brenner C, Masri S, Benitah SA, Sassone-Corsi P. Circadian Reprogramming in the Liver Identifies Metabolic Pathways of Aging. Cell. 170: 664-677.e11. PMID 28802039 DOI: 10.1016/J.Cell.2017.07.042  0.306
2017 Wilsbacher JL, Cheng M, Cheng D, Trammell SAJ, Shi Y, Guo J, Koeniger SL, Kovar PJ, He Y, Selvaraju S, Heyman HR, Sorensen BK, Clark RF, Hansen TM, Longenecker KL, ... ... Brenner C, et al. Discovery and Characterization of Novel Non-substrate and Substrate NAMPT Inhibitors. Molecular Cancer Therapeutics. PMID 28468779 DOI: 10.1158/1535-7163.Mct-16-0819  0.694
2016 Ratajczak J, Joffraud M, Trammell SA, Ras R, Canela N, Boutant M, Kulkarni SS, Rodrigues M, Redpath P, Migaud ME, Auwerx J, Yanes O, Brenner C, Cantó C. NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells. Nature Communications. 7: 13103. PMID 27725675 DOI: 10.1038/Ncomms13103  0.704
2016 Trammell SA, Schmidt MS, Weidemann BJ, Redpath P, Jaksch F, Dellinger RW, Li Z, Abel ED, Migaud ME, Brenner C. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nature Communications. 7: 12948. PMID 27721479 DOI: 10.1038/Ncomms12948  0.649
2016 Trammell SA, Weidemann BJ, Chadda A, Yorek MS, Holmes A, Coppey LJ, Obrosov A, Kardon RH, Yorek MA, Brenner C. Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice. Scientific Reports. 6: 26933. PMID 27230286 DOI: 10.1038/Srep26933  0.596
2016 Trammell SA, Yu L, Redpath P, Migaud ME, Brenner C. Nicotinamide Riboside Is a Major NAD+ Precursor Vitamin in Cow Milk. The Journal of Nutrition. PMID 27052539 DOI: 10.3945/Jn.116.230078  0.64
2016 Wilk AM, Fouquerel E, Johnston B, Trammell SAJ, Schambeau L, Andrews JF, Pannell L, Cooper SJ, Brenner C, Sobol RW. Abstract 4: Hyper activation of poly(ADP-ribose) polymerase 1 initiates large-scale metabolic changes in a cellular model of glioblastoma Cancer Research. 76: 4-4. DOI: 10.1158/1538-7445.Am2016-4  0.39
2015 Trammell SA, Brenner C. NNMT: A Bad Actor in Fat Makes Good in Liver. Cell Metabolism. 22: 200-1. PMID 26244929 DOI: 10.1016/J.Cmet.2015.07.017  0.602
2015 Mei SC, Brenner C. Calorie restriction-mediated replicative lifespan extension in yeast is non-cell autonomous. Plos Biology. 13: e1002048. PMID 25633578 DOI: 10.1371/Journal.Pbio.1002048  0.353
2014 Boylston JA, Brenner C. A knockdown with smoke model reveals FHIT as a repressor of Heme oxygenase 1. Cell Cycle (Georgetown, Tex.). 13: 2913-30. PMID 25486479 DOI: 10.4161/15384101.2014.946858  0.769
2014 Wu BK, Mei SC, Brenner C. RFTS-deleted DNMT1 enhances tumorigenicity with focal hypermethylation and global hypomethylation. Cell Cycle (Georgetown, Tex.). 13: 3222-31. PMID 25485502 DOI: 10.4161/15384101.2014.950886  0.533
2014 Brenner C. Boosting NAD to spare hearing. Cell Metabolism. 20: 926-7. PMID 25470539 DOI: 10.1016/J.Cmet.2014.11.015  0.305
2014 Wu BK, Brenner C. Suppression of TET1-dependent DNA demethylation is essential for KRAS-mediated transformation. Cell Reports. 9: 1827-40. PMID 25466250 DOI: 10.1016/J.Celrep.2014.10.063  0.545
2014 Mei SC, Brenner C. Quantification of protein copy number in yeast: the NAD+ metabolome. Plos One. 9: e106496. PMID 25188219 DOI: 10.1371/Journal.Pone.0106496  0.436
2014 Brenner C. Metabolism: Targeting a fat-accumulation gene. Nature. 508: 194-5. PMID 24717510 DOI: 10.1038/508194A  0.354
2013 Trammell SA, Brenner C. Targeted, LCMS-based Metabolomics for Quantitative Measurement of NAD(+) Metabolites. Computational and Structural Biotechnology Journal. 4: e201301012. PMID 24688693 DOI: 10.5936/Csbj.201301012  0.659
2013 Fagan RL, Wu M, Chédin F, Brenner C. An ultrasensitive high throughput screen for DNA methyltransferase 1-targeted molecular probes. Plos One. 8: e78752. PMID 24236046 DOI: 10.1371/Journal.Pone.0078752  0.321
2013 Ghanta S, Grossmann RE, Brenner C. Mitochondrial protein acetylation as a cell-intrinsic, evolutionary driver of fat storage: chemical and metabolic logic of acetyl-lysine modifications. Critical Reviews in Biochemistry and Molecular Biology. 48: 561-74. PMID 24050258 DOI: 10.3109/10409238.2013.838204  0.323
2012 Midtkandal RR, Redpath P, Trammell SA, Macdonald SJ, Brenner C, Migaud ME. Novel synthetic route to the C-nucleoside, 2-deoxy benzamide riboside. Bioorganic & Medicinal Chemistry Letters. 22: 5204-7. PMID 22795628 DOI: 10.1016/J.Bmcl.2012.06.069  0.598
2011 Belenky P, Stebbins R, Bogan KL, Evans CR, Brenner C. Nrt1 and Tna1-independent export of NAD+ precursor vitamins promotes NAD+ homeostasis and allows engineering of vitamin production. Plos One. 6: e19710. PMID 21589930 DOI: 10.1371/Journal.Pone.0019710  0.804
2011 Brenner C. On the nonspecific degradation of NAD+ to nicotinamide riboside. The Journal of Biological Chemistry. 286: le5; author reply Ie. PMID 21572049 DOI: 10.1074/Jbc.L110.217885  0.316
2011 Syeda F, Fagan RL, Wean M, Avvakumov GV, Walker JR, Xue S, Dhe-Paganon S, Brenner C. The replication focus targeting sequence (RFTS) domain is a DNA-competitive inhibitor of Dnmt1. The Journal of Biological Chemistry. 286: 15344-51. PMID 21389349 DOI: 10.1074/Jbc.M110.209882  0.326
2010 Evans C, Bogan KL, Song P, Burant CF, Kennedy RT, Brenner C. NAD+ metabolite levels as a function of vitamins and calorie restriction: evidence for different mechanisms of longevity. Bmc Chemical Biology. 10: 2. PMID 20175898 DOI: 10.1186/1472-6769-10-2  0.818
2010 Bogan KL, Evans C, Belenky P, Song P, Burant CF, Kennedy R, Brenner C. Identification of Isn1 and Sdt1 as glucose- and vitamin-regulated nicotinamide mononucleotide and nicotinic acid mononucleotide 5′-nucleotidases responsible for production of nicotinamide riboside and nicotinic acid riboside (Journal of Biological Chemistry (2009), 284 (34861-34869)) Journal of Biological Chemistry. 285: 3524. DOI: 10.1074/Jbc.A109.056689  0.774
2010 Bogan KL, Brenner C. 5'-Nucleotidases and their new roles in NAD+ and phosphate metabolism New Journal of Chemistry. 34: 845-853. DOI: 10.1039/B9Nj00758J  0.816
2009 Bogan KL, Evans C, Belenky P, Song P, Burant CF, Kennedy R, Brenner C. Identification of Isn1 and Sdt1 as glucose- and vitamin-regulated nicotinamide mononucleotide and nicotinic acid mononucleotide [corrected] 5'-nucleotidases responsible for production of nicotinamide riboside and nicotinic acid riboside. The Journal of Biological Chemistry. 284: 34861-9. PMID 19846558 DOI: 10.1074/Jbc.M109.056689  0.803
2009 Gazzaniga F, Stebbins R, Chang SZ, McPeek MA, Brenner C. Microbial NAD metabolism: lessons from comparative genomics. Microbiology and Molecular Biology Reviews : Mmbr. 73: 529-41, Table of Con. PMID 19721089 DOI: 10.1128/Mmbr.00042-08  0.45
2009 Belenky P, Christensen KC, Gazzaniga F, Pletnev AA, Brenner C. Nicotinamide riboside and nicotinic acid riboside salvage in fungi and mammals. Quantitative basis for Urh1 and purine nucleoside phosphorylase function in NAD+ metabolism. The Journal of Biological Chemistry. 284: 158-64. PMID 19001417 DOI: 10.1074/Jbc.M807976200  0.761
2008 Brooks L, Heimsath EG, Loring GL, Brenner C. FHA-RING ubiquitin ligases in cell division cycle control Cellular and Molecular Life Sciences. 65: 3458-3466. PMID 18597043 DOI: 10.1007/S00018-008-8220-1  0.312
2008 Linster CL, Adler LN, Webb K, Christensen KC, Brenner C, Clarke SG. A second GDP-L-galactose phosphorylase in arabidopsis en route to vitamin C. Covalent intermediate and substrate requirements for the conserved reaction. The Journal of Biological Chemistry. 283: 18483-92. PMID 18463094 DOI: 10.1074/Jbc.M802594200  0.41
2008 Bogan KL, Brenner C. Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition. Annual Review of Nutrition. 28: 115-30. PMID 18429699 DOI: 10.1146/Annurev.Nutr.28.061807.155443  0.792
2008 Belenky PA, Moga TG, Brenner C. Saccharomyces cerevisiae YOR071C encodes the high affinity nicotinamide riboside transporter Nrt1. The Journal of Biological Chemistry. 283: 8075-9. PMID 18258590 DOI: 10.1074/Jbc.C800021200  0.743
2008 Loring GL, Christensen KC, Gerber SA, Brenner C. Yeast Chfr homologs retard cell cycle at G1 and G2/M via Ubc4 and Ubc13/Mms2-dependent ubiquitination. Cell Cycle (Georgetown, Tex.). 7: 96-105. PMID 18202552 DOI: 10.4161/Cc.7.1.5113  0.35
2007 Tempel W, Rabeh WM, Bogan KL, Belenky P, Wojcik M, Seidle HF, Nedyalkova L, Yang T, Sauve AA, Park HW, Brenner C. Nicotinamide riboside kinase structures reveal new pathways to NAD+. Plos Biology. 5: e263. PMID 17914902 DOI: 10.1371/Journal.Pbio.0050263  0.799
2007 Belenky P, Racette FG, Bogan KL, McClure JM, Smith JS, Brenner C. Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+. Cell. 129: 473-84. PMID 17482543 DOI: 10.1016/J.Cell.2007.03.024  0.791
2007 Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG. Arabidopsis VTC2 encodes a GDP-L-galactose phosphorylase, the last unknown enzyme in the Smirnoff-Wheeler pathway to ascorbic acid in plants. The Journal of Biological Chemistry. 282: 18879-85. PMID 17462988 DOI: 10.1074/Jbc.M702094200  0.347
2007 Belenky P, Bogan KL, Brenner C. NAD+ metabolism in health and disease. Trends in Biochemical Sciences. 32: 12-9. PMID 17161604 DOI: 10.1016/J.Tibs.2006.11.006  0.791
2006 Wojcik M, Seidle HF, Bieganowski P, Brenner C. Glutamine-dependent NAD+ synthetase. How a two-domain, three-substrate enzyme avoids waste. The Journal of Biological Chemistry. 281: 33395-402. PMID 16954203 DOI: 10.1074/Jbc.M607111200  0.737
2006 Martin J, Magnino F, Schmidt K, Piguet AC, Lee JS, Semela D, St-Pierre MV, Ziemiecki A, Cassio D, Brenner C, Thorgeirsson SS, Dufour JF. Hint2, a mitochondrial apoptotic sensitizer down-regulated in hepatocellular carcinoma. Gastroenterology. 130: 2179-88. PMID 16762638 DOI: 10.1053/J.Gastro.2006.03.024  0.319
2006 Bieganowski P, Seidle HF, Wojcik M, Brenner C. Synthetic lethal and biochemical analyses of NAD and NADH kinases in Saccharomyces cerevisiae establish separation of cellular functions. The Journal of Biological Chemistry. 281: 22439-45. PMID 16760478 DOI: 10.1074/Jbc.M513919200  0.718
2005 Brenner C. Evolution of NAD biosynthetic enzymes. Structure (London, England : 1993). 13: 1239-40. PMID 16154080 DOI: 10.1016/J.Str.2005.08.004  0.312
2005 Seidle HF, Bieganowski P, Brenner C. Disease-associated mutations inactivate AMP-lysine hydrolase activity of Aprataxin. The Journal of Biological Chemistry. 280: 20927-31. PMID 15790557 DOI: 10.1074/Jbc.M502889200  0.714
2005 Chou TF, Bieganowski P, Shilinski K, Cheng J, Brenner C, Wagner CR. 31P NMR and genetic analysis establish hinT as the only Escherchia coli purine nucleoside phosphoramidase and as essential for growth under high salt conditions. The Journal of Biological Chemistry. 280: 15356-61. PMID 15703176 DOI: 10.1074/Jbc.M500434200  0.73
2004 Parks KP, Seidle H, Wright N, Sperry JB, Bieganowski P, Howitz K, Wright DL, Brenner C. Altered specificity of Hint-W123Q supports a role for Hint inhibition by ASW in avian sex determination. Physiological Genomics. 20: 12-4. PMID 15507519 DOI: 10.1152/Physiolgenomics.00204.2004  0.726
2004 Clements PM, Breslin C, Deeks ED, Byrd PJ, Ju L, Bieganowski P, Brenner C, Moreira MC, Taylor AM, Caldecott KW. The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4. Dna Repair. 3: 1493-502. PMID 15380105 DOI: 10.1016/J.Dnarep.2004.06.017  0.689
2004 Bieganowski P, Shilinski K, Tsichlis PN, Brenner C. Cdc123 and checkpoint forkhead associated with RING proteins control the cell cycle by controlling eIF2gamma abundance. The Journal of Biological Chemistry. 279: 44656-66. PMID 15319434 DOI: 10.1074/Jbc.M406151200  0.703
2004 Bieganowski P, Brenner C. Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. Cell. 117: 495-502. PMID 15137942 DOI: 10.1016/S0092-8674(04)00416-7  0.738
2004 Krakowiak A, Pace HC, Blackburn GM, Adams M, Mekhalfia A, Kaczmarek R, Baraniak J, Stec WJ, Brenner C. Biochemical, crystallographic, and mutagenic characterization of hint, the AMP-lysine hydrolase, with novel substrates and inhibitors. The Journal of Biological Chemistry. 279: 18711-6. PMID 14982931 DOI: 10.1074/Jbc.M314271200  0.392
2003 Brenner C. Subtleties among subtilases. The structural biology of Kex2 and furin-related prohormone convertases. Embo Reports. 4: 937-8. PMID 14528262 DOI: 10.1038/Sj.Embor.Embor946  0.328
2003 Kwasnicka DA, Krakowiak A, Thacker C, Brenner C, Vincent SR. Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1. The Journal of Biological Chemistry. 278: 39051-8. PMID 12871939 DOI: 10.1074/Jbc.M306355200  0.393
2003 Bieganowski P, Brenner C. The reported human NADsyn2 is ammonia-dependent NAD synthetase from a pseudomonad. The Journal of Biological Chemistry. 278: 33056-9. PMID 12777395 DOI: 10.1074/Jbc.M302276200  0.744
2003 Bieganowski P, Pace HC, Brenner C. Eukaryotic NAD+ synthetase Qns1 contains an essential, obligate intramolecular thiol glutamine amidotransferase domain related to nitrilase. The Journal of Biological Chemistry. 278: 33049-55. PMID 12771147 DOI: 10.1074/Jbc.M302257200  0.746
2003 Pace HC, Brenner C. Feminizing chicks: a model for avian sex determination based on titration of Hint enzyme activity and the predicted structure of an Asw-Hint heterodimer. Genome Biology. 4: R18. PMID 12620103 DOI: 10.1186/Gb-2003-4-3-R18  0.397
2003 Trapasso F, Krakowiak A, Cesari R, Arkles J, Yendamuri S, Ishii H, Vecchione A, Kuroki T, Bieganowski P, Pace HC, Huebner K, Croce CM, Brenner C. Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding. Proceedings of the National Academy of Sciences of the United States of America. 100: 1592-7. PMID 12574506 DOI: 10.1073/Pnas.0437915100  0.712
2002 Brenner C. Catalysis in the nitrilase superfamily. Current Opinion in Structural Biology. 12: 775-82. PMID 12504683 DOI: 10.1016/S0959-440X(02)00387-1  0.324
2002 Brenner C. Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases. Biochemistry. 41: 9003-14. PMID 12119013 DOI: 10.1021/Bi025942Q  0.419
2002 Rubio-Texeira M, Varnum JM, Bieganowski P, Brenner C. Control of dinucleoside polyphosphates by the FHIT-homologous HNT2 gene, adenine biosynthesis and heat shock in Saccharomyces cerevisiae. Bmc Molecular Biology. 3: 7. PMID 12028594 DOI: 10.1186/1471-2199-3-7  0.71
2002 Bieganowski P, Garrison PN, Hodawadekar SC, Faye G, Barnes LD, Brenner C. Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3. The Journal of Biological Chemistry. 277: 10852-60. PMID 11805111 DOI: 10.1074/Jbc.M111480200  0.726
2001 Varnum JM, Baraniak J, Kaczmarek R, Stec WJ, Brenner C. Di-, tri- and tetra-5'-O-phosphorothioadenosyl substituted polyols as inhibitors of Fhit: Importance of the alpha-beta bridging oxygen and beta phosphorus replacement. Bmc Chemical Biology. 1: 3. PMID 11701096 DOI: 10.1186/1472-6769-1-3  0.37
2001 Pace HC, Brenner C. The nitrilase superfamily: Classification, structure and function Genome Biology. 2. PMID 11380987 DOI: 10.1186/Gb-2001-2-1-Reviews0001  0.344
2001 Dahéron L, Zenz T, Siracusa LD, Brenner C, Calabretta B. Molecular cloning of Ian4: A BCR/ABL-induced gene that encodes an outer membrane mitochondrial protein with GTP-binding activity Nucleic Acids Research. 29: 1308-1316. PMID 11238997 DOI: 10.1093/Nar/29.6.1308  0.367
2001 McLennan AG, Barnes LD, Blackburn GM, Brenner C, Guranowski A, Miller AD, Rovira JM, Rotllán P, Soria B, Tanner JA, Sillero A. Recent progress in the study of the intracellular functions of diadenosine polyphosphates Drug Development Research. 52: 249-259. DOI: 10.1002/Ddr.1122  0.407
2000 Boyne JR, Yosuf HM, Bieganowski P, Brenner C, Price C. Yeast myosin light chain, Mlc1p, interacts with both IQGAP and class II myosin to effect cytokinesis. Journal of Cell Science. 113: 4533-43. PMID 11082046  0.657
2000 Brenner C. Condensing the RNA world Trends in Biochemical Sciences. 25: 485-485. PMID 11050431 DOI: 10.1016/S0968-0004(00)01678-9  0.311
2000 Pace HC, Hodawadekar SC, Draganescu A, Huang J, Bieganowski P, Pekarsky Y, Croce CM, Brenner C. Crystal structure of the worm NitFhit Rosetta Stone protein reveals a Nit tetramer binding two Fhit dimers. Current Biology : Cb. 10: 907-17. PMID 10959838 DOI: 10.1016/S0960-9822(00)00621-7  0.699
2000 Draganescu A, Hodawadekar SC, Gee KR, Brenner C. Fhit-nucleotide specificity probed with novel fluorescent and fluorogenic substrates. The Journal of Biological Chemistry. 275: 4555-60. PMID 10671479 DOI: 10.1074/Jbc.275.7.4555  0.326
1999 Brenner C, Bieganowski P, Pace HC, Huebner K. The histidine triad superfamily of nucleotide-binding proteins. Journal of Cellular Physiology. 181: 179-87. PMID 10497298 DOI: 10.1002/(Sici)1097-4652(199911)181:2<179::Aid-Jcp1>3.0.Co;2-8  0.698
1999 Brenner C. FHIT-substrate complexes: A new paradigm in reversible protein phosphorylation Phosphorus, Sulfur and Silicon and Related Elements. 144: 745-748. DOI: 10.1080/10426509908546352  0.357
1998 Bevan A, Brenner C, Fuller RS. Quantitative assessment of enzyme specificity in vivo: P2 recognition by Kex2 protease defined in a genetic system. Proceedings of the National Academy of Sciences of the United States of America. 95: 10384-9. PMID 9724712 DOI: 10.1073/Pnas.95.18.10384  0.622
1998 Pekarsky Y, Campiglio M, Siprashvili Z, Druck T, Sedkov Y, Tillib S, Draganescu A, Wermuth P, Rothman JH, Huebner K, Buchberg AM, Mazo A, Brenner C, Croce CM. Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 95: 8744-9. PMID 9671749 DOI: 10.1073/Pnas.95.15.8744  0.34
1998 Pace HC, Garrison PN, Robinson AK, Barnes LD, Draganescu A, Rösler A, Blackburn GM, Siprashvili Z, Croce CM, Huebner K, Brenner C. Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit. Proceedings of the National Academy of Sciences of the United States of America. 95: 5484-9. PMID 9576908 DOI: 10.1073/Pnas.95.10.5484  0.393
1997 Brenner C, Pace HC, Garrison PN, Robinson AK, Rosler A, Liu XH, Blackburn GM, Croce CM, Huebner K, Barnes LD. Purification and crystallization of complexes modeling the active state of the fragile histidine triad protein. Protein Engineering. 10: 1461-3. PMID 9543008 DOI: 10.1093/Protein/10.12.1461  0.335
1997 Brenner C, Garrison P, Gilmour J, Peisach D, Ringe D, Petsko GA, Lowenstein JM. Crystal structures of HINT demonstrate that histidine triad proteins are GalT-related nucleotide-binding proteins. Nature Structural Biology. 4: 231-8. PMID 9164465 DOI: 10.1038/Nsb0397-231  0.495
1994 Brenner C, Bevan A, Fuller RS. Biochemical and genetic methods for analyzing specificity and activity of a precursor-processing enzyme: yeast Kex2 protease, kexin. Methods in Enzymology. 244: 152-67. PMID 7845204 DOI: 10.1016/0076-6879(94)44013-1  0.668
1993 Brenner C, Bevan A, Fuller RS. One-step site-directed mutagenesis of the Kex2 protease oxyanion hole. Current Biology : Cb. 3: 498-506. PMID 15335687 DOI: 10.1016/0960-9822(93)90040-U  0.656
1993 Angliker H, Wikstrom P, Shaw E, Brenner C, Fuller RS. The synthesis of inhibitors for processing proteinases and their action on the Kex2 proteinase of yeast. The Biochemical Journal. 293: 75-81. PMID 8328974 DOI: 10.1042/Bj2930075  0.633
1992 Brenner C, Fuller RS. Structural and enzymatic characterization of a purified prohormone-processing enzyme: secreted, soluble Kex2 protease. Proceedings of the National Academy of Sciences of the United States of America. 89: 922-6. PMID 1736307 DOI: 10.1073/Pnas.89.3.922  0.665
1987 Miyajima I, Nakafuku M, Nakayama N, Brenner C, Miyajima A, Kaibuchi K, Arai Ki, Kaziro Y, Matsumoto K. GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction Cell. 50: 1011-1019. PMID 3113739 DOI: 10.1016/0092-8674(87)90167-X  0.333
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