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Jeroen Saeij - Publications

Affiliations: 
2007-2015 Biology Massachusetts Institute of Technology, Cambridge, MA, United States 
 2015- Pathology, Microbiology & Immunology University of California, Davis, Davis, CA 
Area:
Toxoplasma, host-parasite interactions
Website:
https://saeijlab.faculty.ucdavis.edu/
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93 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Wang Y, Hollingsworth LR, Sangaré LO, Paredes-Santos TC, Krishnamurthy S, Penn BH, Wu H, Saeij JPJ. Host E3 ubiquitin ligase ITCH mediates effector GRA35-triggered NLRP1 inflammasome activation and cell-autonomous immunity. Mbio. e0330223. PMID 38376248 DOI: 10.1128/mbio.03302-23  0.434
2023 Wang Y, Hollingsworth LR, Sangaré LO, Paredes-Santos TC, Krishnamurthy S, Penn BH, Wu H, Saeij JPJ. Host E3 ubiquitin ligase ITCH mediates effector GRA35-triggered NLRP1 inflammasome activation and cell-autonomous immunity. Biorxiv : the Preprint Server For Biology. PMID 38168400 DOI: 10.1101/2023.12.13.571530  0.83
2023 Bitew MA, Gaete PS, Swale C, Maru P, Contreras JE, Saeij JPJ. GRA47 and GRA72 are pore-forming proteins that influence small molecule permeability of the parasitophorous vacuole. Biorxiv : the Preprint Server For Biology. PMID 38014337 DOI: 10.1101/2023.11.15.567216  0.801
2023 Paredes-Santos TC, Bitew MA, Swale C, Rodriguez F, Krishnamurthy S, Wang Y, Maru P, Sangaré LO, Saeij JPJ. Genome-wide CRISPR screen identifies genes synthetically lethal with GRA17, a nutrient channel encoding gene in Toxoplasma. Plos Pathogens. 19: e1011543. PMID 37498952 DOI: 10.1371/journal.ppat.1011543  0.798
2023 Krishnamurthy S, Maru P, Wang Y, Bitew MA, Mukhopadhyay D, Yamaryo-Botté Y, Paredes-Santos TC, Sangaré LO, Swale C, Botté CY, Saeij JPJ. CRISPR Screens Identify Genes That Determine Parasite Fitness in Interferon Gamma-Stimulated Human Cells. Mbio. e0006023. PMID 36916910 DOI: 10.1128/mbio.00060-23  0.795
2023 Gonzales-Viera O, Arranz-Solís D, Smith J, Saeij JPJ, Mete A. Fatal Sarcocystis calchasi hepatitis in a captive Indian ringneck parakeet (Psittacula krameri manillensis). Veterinary Parasitology, Regional Studies and Reports. 39: 100841. PMID 36878626 DOI: 10.1016/j.vprsr.2023.100841  0.722
2023 Arranz-Solís D, Warschkau D, Fabian BT, Seeber F, Saeij JPJ. Late Embryogenesis Abundant Proteins Contribute to the Resistance of Toxoplasma gondii Oocysts against Environmental Stresses. Mbio. e0286822. PMID 36809045 DOI: 10.1128/mbio.02868-22  0.758
2022 Ten Hoeve AL, Braun L, Rodriguez ME, Olivera GC, Bougdour A, Belmudes L, Couté Y, Saeij JPJ, Hakimi MA, Barragan A. The Toxoplasma effector GRA28 promotes parasite dissemination by inducing dendritic cell-like migratory properties in infected macrophages. Cell Host & Microbe. 30: 1570-1588.e7. PMID 36309013 DOI: 10.1016/j.chom.2022.10.001  0.413
2022 Rico-San Román L, Amieva R, Regidor-Cerrillo J, García-Sánchez M, Collantes-Fernández E, Pastor-Fernández I, Saeij JPJ, Ortega-Mora LM, Horcajo P. Nc and Nc Play a Role in the Virulence of in a Pregnant Mouse Model. Pathogens (Basel, Switzerland). 11. PMID 36145430 DOI: 10.3390/pathogens11090998  0.379
2022 Ross EC, Hoeve ALT, Saeij JPJ, Barragan A. effector-induced ICAM-1 expression by infected dendritic cells potentiates transmigration across polarised endothelium. Frontiers in Immunology. 13: 950914. PMID 35990682 DOI: 10.3389/fimmu.2022.950914  0.352
2022 Arranz-Solís D, Saeij JPJ. New Avenues to Design Vaccines Based on Oocysts and Cysts. Frontiers in Immunology. 13: 910961. PMID 35734184 DOI: 10.3389/fimmu.2022.910961  0.737
2022 Rogers KH, Arranz-Solís D, Saeij JPJ, Lewis S, Mete A. and other Sarcocystidae detected in predatory birds in California, USA. International Journal For Parasitology. Parasites and Wildlife. 17: 91-99. PMID 35004169 DOI: 10.1016/j.ijppaw.2021.12.008  0.764
2021 Glausen TG, Carrillo GL, Jin RM, Boyle JP, Saeij JPJ, Wohlfert EA, Fox MA, Blader IJ. The Polymorphic Effector GRA15 Mediates Seizure Induction by Modulating Interleukin-1 Signaling in the Brain. Mbio. e0133121. PMID 34154412 DOI: 10.1128/mBio.01331-21  0.77
2021 Sangaré LO, Wang Y, Arranz-Solís D, Saeij JPJ. CRISPR screen to determine the fitness of genes. Star Protocols. 2: 100520. PMID 34013213 DOI: 10.1016/j.xpro.2021.100520  0.82
2021 Tomita T, Mukhopadhyay D, Han B, Yakubu R, Tu V, Mayoral J, Sugi T, Ma Y, Saeij JPJ, Weiss LM. Toxoplasma gondii Matrix Antigen 1 Is a Secreted Immunomodulatory Effector. Mbio. 12. PMID 34006649 DOI: 10.1128/mBio.00603-21  0.796
2021 Arranz-Solís D, Carvalheiro CG, Zhang ER, Grigg ME, Saeij JPJ. GRA Peptide-Specific Serologic Fingerprints Discriminate Among Major Strains Causing Toxoplasmosis. Frontiers in Cellular and Infection Microbiology. 11: 621738. PMID 33680990 DOI: 10.3389/fcimb.2021.621738  0.729
2020 Arranz-Solís D, Mukhopadhyay D, Saeij JJP. Toxoplasma Effectors that Affect Pregnancy Outcome. Trends in Parasitology. PMID 33234405 DOI: 10.1016/j.pt.2020.10.013  0.835
2020 Mukhopadhyay D, Arranz-Solís D, Saeij JPJ. Influence of the Host and Parasite Strain on the Immune Response During Infection. Frontiers in Cellular and Infection Microbiology. 10: 580425. PMID 33178630 DOI: 10.3389/fcimb.2020.580425  0.845
2020 Wang Y, Sangaré LO, Paredes-Santos TC, Hassan MA, Krishnamurthy S, Furuta AM, Markus BM, Lourido S, Saeij JPJ. Genome-wide screens identify Toxoplasma gondii determinants of parasite fitness in IFNγ-activated murine macrophages. Nature Communications. 11: 5258. PMID 33067458 DOI: 10.1038/s41467-020-18991-8  0.837
2020 Kongsomboonvech AK, Rodriguez F, Diep AL, Justice BM, Castallanos BE, Camejo A, Mukhopadhyay D, Taylor GA, Yamamoto M, Saeij JPJ, Reese ML, Jensen KDC. Naïve CD8 T cell IFNγ responses to a vacuolar antigen are regulated by an inflammasome-independent NLRP3 pathway and Toxoplasma gondii ROP5. Plos Pathogens. 16: e1008327. PMID 32853276 DOI: 10.1371/Journal.Ppat.1008327  0.825
2020 Wang Y, Sangaré LO, Paredes-Santos TC, Saeij JPJ. Mechanisms for Delivery of Proteins and Uptake of Nutrients Across the Host-Pathogen Interface. Annual Review of Microbiology. PMID 32680452 DOI: 10.1146/annurev-micro-011720-122318  0.832
2020 Bamac OE, Rogers KH, Arranz-Solís D, Saeij JPJ, Lewis S, Duerr R, Skoglund J, Peronne L, Mete A. Protozoal encephalitis associated with and during an epizootic involving Brandt's cormorants () in coastal Southern California, USA. International Journal For Parasitology. Parasites and Wildlife. 12: 185-191. PMID 32617260 DOI: 10.1016/j.ijppaw.2020.06.005  0.757
2020 Mukhopadhyay D, Arranz-Solís D, Saeij JPJ. Toxoplasma  GRA15 and GRA24 are important activators of the host innate immune response in the absence of TLR11. Plos Pathogens. 16: e1008586. PMID 32453782 DOI: 10.1371/journal.ppat.1008586  0.816
2020 Rico-San Román L, Horcajo P, Regidor-Cerrillo J, Fernández-Escobar M, Collantes-Fernández E, Gutiérrez-Blázquez D, Hernáez-Sánchez ML, Saeij JPJ, Ortega-Mora LM. Comparative tachyzoite proteome analyses among six Neospora caninum isolates with different virulence. International Journal For Parasitology. PMID 32360428 DOI: 10.1016/j.ijpara.2020.02.003  0.339
2020 Mukhopadhyay D, Sangaré LO, Braun L, Hakimi MA, Saeij JP. Toxoplasma GRA15 limits parasite growth in IFNγ-activated fibroblasts through TRAF ubiquitin ligases. The Embo Journal. e103758. PMID 32293748 DOI: 10.15252/embj.2019103758  0.841
2020 Waldman BS, Schwarz D, Wadsworth MH, Saeij JP, Shalek AK, Lourido S. Identification of a Master Regulator of Differentiation in Toxoplasma. Cell. 180: 359-372.e16. PMID 31955846 DOI: 10.1016/J.Cell.2019.12.013  0.395
2020 Mukhopadhyay D, Saeij JPJ. Assays to Evaluate Toxoplasma-Macrophage Interactions. Methods in Molecular Biology (Clifton, N.J.). 2071: 347-370. PMID 31758462 DOI: 10.1007/978-1-4939-9857-9_19  0.777
2019 Arranz-Solís D, Cordeiro C, Young LH, Dardé ML, Commodaro AG, Grigg ME, Saeij JPJ. Serotyping of Infection Using Peptide Membrane Arrays. Frontiers in Cellular and Infection Microbiology. 9: 408. PMID 31850240 DOI: 10.3389/fcimb.2019.00408  0.772
2019 Sangaré LO, Ólafsson EB, Wang Y, Yang N, Julien L, Camejo A, Pesavento P, Sidik SM, Lourido S, Barragan A, Saeij JPJ. In Vivo CRISPR Screen Identifies TgWIP as a Toxoplasma Modulator of Dendritic Cell Migration. Cell Host & Microbe. 26: 478-492.e8. PMID 31600500 DOI: 10.1016/J.Chom.2019.09.008  0.81
2019 Paredes-Santos T, Wang Y, Waldman B, Lourido S, Saeij JP. The GRA17 Parasitophorous Vacuole Membrane Permeability Pore Contributes to Bradyzoite Viability. Frontiers in Cellular and Infection Microbiology. 9: 321. PMID 31572690 DOI: 10.3389/Fcimb.2019.00321  0.601
2019 Sangaré LO, Yang N, Konstantinou EK, Lu D, Mukhopadhyay D, Young LH, Saeij JPJ. GRA15 Activates the NF-κB Pathway through Interactions with TNF Receptor-Associated Factors. Mbio. 10. PMID 31311877 DOI: 10.1128/Mbio.00808-19  0.791
2019 Wang Y, Cirelli KM, Barros PDC, Sangaré LO, Butty V, Hassan MA, Pesavento P, Mete A, Saeij JPJ. Three Dense Granule Proteins Are Required for Induction of Lewis Rat Macrophage Pyroptosis. Mbio. 10. PMID 30622189 DOI: 10.1128/mBio.02388-18  0.81
2019 Hassan MA, Olijnik AA, Frickel EM, Saeij JP. Clonal and atypical Toxoplasma strain differences in virulence vary with mouse sub-species. International Journal For Parasitology. 49: 63-70. PMID 30471286 DOI: 10.1016/j.ijpara.2018.08.007  0.771
2018 Krishnamurthy S, Saeij JPJ. Does Not Secrete the GRA16 and GRA24 Effectors Beyond the Parasitophorous Vacuole Membrane of Tissue Cysts. Frontiers in Cellular and Infection Microbiology. 8: 366. PMID 30406043 DOI: 10.3389/fcimb.2018.00366  0.782
2018 Arranz-Solís D, Regidor-Cerrillo J, Lourido S, Ortega-Mora LM, Saeij JPJ. Toxoplasma CRISPR/Cas9 constructs are functional for gene disruption in Neospora caninum. International Journal For Parasitology. PMID 29625127 DOI: 10.1016/J.Ijpara.2018.03.002  0.784
2017 Saeij JP, Frickel EM. Exposing Toxoplasma gondii hiding inside the vacuole: a role for GBPs, autophagy and host cell death. Current Opinion in Microbiology. 40: 72-80. PMID 29141239 DOI: 10.1016/j.mib.2017.10.021  0.531
2017 Krishnamurthy S, Konstantinou EK, Young LH, Gold DA, Saeij JP. The human immune response to Toxoplasma: Autophagy versus cell death. Plos Pathogens. 13: e1006176. PMID 28278184 DOI: 10.1371/Journal.Ppat.1006176  0.79
2016 Sidik SM, Huet D, Ganesan SM, Huynh MH, Wang T, Nasamu AS, Thiru P, Saeij JP, Carruthers VB, Niles JC, Lourido S. A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Cell. PMID 27594426 DOI: 10.1016/J.Cell.2016.08.019  0.497
2016 Fink A, Hassan MA, Okan NA, Sheffer M, Camejo A, Saeij JP, Kasper DL. Early Interactions of Murine Macrophages with Francisella tularensis Map to Mouse Chromosome 19. Mbio. 7. PMID 26980837 DOI: 10.1128/Mbio.02243-15  0.765
2016 Lorenzi H, Khan A, Behnke MS, Namasivayam S, Swapna LS, Hadjithomas M, Karamycheva S, Pinney D, Brunk BP, Ajioka JW, Ajzenberg D, Boothroyd JC, Boyle JP, Dardé ML, Diaz-Miranda MA, ... ... Saeij JP, et al. Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes. Nature Communications. 7: 10147. PMID 26738725 DOI: 10.1038/Ncomms10147  0.74
2015 Hassan MA, Jensen KD, Butty V, Hu K, Boedec E, Prins P, Saeij JP. Transcriptional and Linkage Analyses Identify Loci that Mediate the Differential Macrophage Response to Inflammatory Stimuli and Infection. Plos Genetics. 11: e1005619. PMID 26510153 DOI: 10.1371/Journal.Pgen.1005619  0.811
2015 Gold DA, Kaplan AD, Lis A, Bett GC, Rosowski EE, Cirelli KM, Bougdour A, Sidik SM, Beck JR, Lourido S, Egea PF, Bradley PJ, Hakimi MA, Rasmusson RL, Saeij JP. The Toxoplasma Dense Granule Proteins GRA17 and GRA23 Mediate the Movement of Small Molecules between the Host and the Parasitophorous Vacuole. Cell Host & Microbe. 17: 642-52. PMID 25974303 DOI: 10.1016/J.Chom.2015.04.003  0.808
2015 Jensen KD, Camejo A, Melo MB, Cordeiro C, Julien L, Grotenbreg GM, Frickel EM, Ploegh HL, Young L, Saeij JP. Toxoplasma gondii superinfection and virulence during secondary infection correlate with the exact ROP5/ROP18 allelic combination. Mbio. 6: e02280. PMID 25714710 DOI: 10.1128/Mbio.02280-14  0.83
2014 Hassan MA, Saeij JP. Incorporating alternative splicing and mRNA editing into the genetic analysis of complex traits. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 36: 1032-40. PMID 25171292 DOI: 10.1002/bies.201400079  0.713
2014 Murray PJ, Allen JE, Biswas SK, Fisher EA, Gilroy DW, Goerdt S, Gordon S, Hamilton JA, Ivashkiv LB, Lawrence T, Locati M, Mantovani A, Martinez FO, Mege JL, Mosser DM, ... ... Saeij JP, et al. Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity. 41: 14-20. PMID 25035950 DOI: 10.1016/J.Immuni.2014.06.008  0.3
2014 Cirelli KM, Gorfu G, Hassan MA, Printz M, Crown D, Leppla SH, Grigg ME, Saeij JP, Moayeri M. Inflammasome sensor NLRP1 controls rat macrophage susceptibility to Toxoplasma gondii. Plos Pathogens. 10: e1003927. PMID 24626226 DOI: 10.1371/Journal.Ppat.1003927  0.815
2014 Cannella D, Brenier-Pinchart MP, Braun L, van Rooyen JM, Bougdour A, Bastien O, Behnke MS, Curt RL, Curt A, Saeij JP, Sibley LD, Pelloux H, Hakimi MA. miR-146a and miR-155 delineate a MicroRNA fingerprint associated with Toxoplasma persistence in the host brain. Cell Reports. 6: 928-37. PMID 24582962 DOI: 10.1016/j.celrep.2014.02.002  0.552
2014 Gorfu G, Cirelli KM, Melo MB, Mayer-Barber K, Crown D, Koller BH, Masters S, Sher A, Leppla SH, Moayeri M, Saeij JP, Grigg ME. Dual role for inflammasome sensors NLRP1 and NLRP3 in murine resistance to Toxoplasma gondii. Mbio. 5. PMID 24549849 DOI: 10.1128/Mbio.01117-13  0.795
2014 Rosowski EE, Nguyen QP, Camejo A, Spooner E, Saeij JP. Toxoplasma gondii Inhibits gamma interferon (IFN-γ)- and IFN-β-induced host cell STAT1 transcriptional activity by increasing the association of STAT1 with DNA. Infection and Immunity. 82: 706-19. PMID 24478085 DOI: 10.1128/IAI.01291-13  0.8
2014 Hassan MA, Butty V, Jensen KD, Saeij JP. The genetic basis for individual differences in mRNA splicing and APOBEC1 editing activity in murine macrophages. Genome Research. 24: 377-89. PMID 24249727 DOI: 10.1101/gr.166033.113  0.784
2014 Camejo A, Gold DA, Lu D, McFetridge K, Julien L, Yang N, Jensen KD, Saeij JP. Identification of three novel Toxoplasma gondii rhoptry proteins. International Journal For Parasitology. 44: 147-60. PMID 24070999 DOI: 10.1016/J.Ijpara.2013.08.002  0.823
2014 Murray PJ, Allen JE, Biswas SK, Fisher EA, Gilroy DW, Goerdt S, Gordon S, Hamilton JA, Ivashkiv LB, Lawrence T, Locati M, Mantovani A, Martinez FO, Mege JL, Mosser DM, ... ... Saeij JP, et al. Correction tp Macrophage activation and polarization: Nomenclature and experimental guidelines [Immunity, 41, 2014 (14-20)] Immunity. 41: 339-340. DOI: 10.1016/J.Immuni.2014.07.009  0.318
2014 Hassan MA, Saeij JPJ. Incorporating alternative splicing and mRNA editing into the genetic analysis of complex traits Bioessays. 36: 1032-1040. DOI: 10.1002/bies.201400079  0.713
2013 Melo MB, Nguyen QP, Cordeiro C, Hassan MA, Yang N, McKell R, Rosowski EE, Julien L, Butty V, Dardé ML, Ajzenberg D, Fitzgerald K, Young LH, Saeij JP. Transcriptional analysis of murine macrophages infected with different Toxoplasma strains identifies novel regulation of host signaling pathways. Plos Pathogens. 9: e1003779. PMID 24367253 DOI: 10.1371/Journal.Ppat.1003779  0.831
2013 Lim D, Gold DA, Julien L, Rosowski EE, Niedelman W, Yaffe MB, Saeij JP. Structure of the Toxoplasma gondii ROP18 kinase domain reveals a second ligand binding pocket required for acute virulence. The Journal of Biological Chemistry. 288: 34968-80. PMID 24129568 DOI: 10.1074/Jbc.M113.523266  0.819
2013 Niedelman W, Sprokholt JK, Clough B, Frickel EM, Saeij JP. Cell death of gamma interferon-stimulated human fibroblasts upon Toxoplasma gondii infection induces early parasite egress and limits parasite replication. Infection and Immunity. 81: 4341-9. PMID 24042117 DOI: 10.1128/IAI.00416-13  0.478
2013 Yang N, Farrell A, Niedelman W, Melo M, Lu D, Julien L, Marth GT, Gubbels MJ, Saeij JP. Genetic basis for phenotypic differences between different Toxoplasma gondii type I strains. Bmc Genomics. 14: 467. PMID 23837824 DOI: 10.1186/1471-2164-14-467  0.823
2013 Jensen KD, Hu K, Whitmarsh RJ, Hassan MA, Julien L, Lu D, Chen L, Hunter CA, Saeij JP. Toxoplasma gondii rhoptry 16 kinase promotes host resistance to oral infection and intestinal inflammation only in the context of the dense granule protein GRA15. Infection and Immunity. 81: 2156-67. PMID 23545295 DOI: 10.1128/Iai.01185-12  0.846
2013 Lim D, Gold DA, Julien L, Rosowski EE, Niedelman W, Yaffe MB, Saeij JPJ. Structure of the toxoplasma gondii ROP18 kinase domain reveals a second ligand binding pocket required for acute virulence Journal of Biological Chemistry. 288: 34968-34980. DOI: 10.1074/jbc.M113.523266  0.764
2012 Rosowski EE, Saeij JP. Toxoplasma gondii clonal strains all inhibit STAT1 transcriptional activity but polymorphic effectors differentially modulate IFNγ induced gene expression and STAT1 phosphorylation. Plos One. 7: e51448. PMID 23240025 DOI: 10.1371/Journal.Pone.0051448  0.802
2012 Hassan MA, Melo MB, Haas B, Jensen KD, Saeij JP. De novo reconstruction of the Toxoplasma gondii transcriptome improves on the current genome annotation and reveals alternatively spliced transcripts and putative long non-coding RNAs. Bmc Genomics. 13: 696. PMID 23231500 DOI: 10.1186/1471-2164-13-696  0.788
2012 Minot S, Melo MB, Li F, Lu D, Niedelman W, Levine SS, Saeij JP. Admixture and recombination among Toxoplasma gondii lineages explain global genome diversity. Proceedings of the National Academy of Sciences of the United States of America. 109: 13458-63. PMID 22847430 DOI: 10.1073/Pnas.1117047109  0.812
2012 Niedelman W, Gold DA, Rosowski EE, Sprokholt JK, Lim D, Arenas AF, Melo MB, Spooner E, Yaffe MB, Saeij JPJ. The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response Plos Pathogens. 8. PMID 22761577 DOI: 10.1371/Journal.Ppat.1002784  0.836
2012 Szatanek T, Anderson-White BR, Faugno-Fusci DM, White M, Saeij JP, Gubbels MJ. Cactin is essential for G1 progression in Toxoplasma gondii. Molecular Microbiology. 84: 566-77. PMID 22486860 DOI: 10.1111/J.1365-2958.2012.08044.X  0.445
2012 Lim DC, Cooke BM, Doerig C, Saeij JP. Toxoplasma and Plasmodium protein kinases: roles in invasion and host cell remodelling. International Journal For Parasitology. 42: 21-32. PMID 22154850 DOI: 10.1016/j.ijpara.2011.11.007  0.412
2011 Virreira Winter S, Niedelman W, Jensen KD, Rosowski EE, Julien L, Spooner E, Caradonna K, Burleigh BA, Saeij JP, Ploegh HL, Frickel EM. Determinants of GBP recruitment to Toxoplasma gondii vacuoles and the parasitic factors that control it. Plos One. 6: e24434. PMID 21931713 DOI: 10.1371/Journal.Pone.0024434  0.846
2011 Melo MB, Jensen KD, Saeij JP. Toxoplasma gondii effectors are master regulators of the inflammatory response. Trends in Parasitology. 27: 487-95. PMID 21893432 DOI: 10.1016/J.Pt.2011.08.001  0.844
2011 Jensen KD, Wang Y, Wojno ED, Shastri AJ, Hu K, Cornel L, Boedec E, Ong YC, Chien YH, Hunter CA, Boothroyd JC, Saeij JP. Toxoplasma polymorphic effectors determine macrophage polarization and intestinal inflammation. Cell Host & Microbe. 9: 472-83. PMID 21669396 DOI: 10.1016/J.Chom.2011.04.015  0.837
2011 Reese ML, Zeiner GM, Saeij JP, Boothroyd JC, Boyle JP. Polymorphic family of injected pseudokinases is paramount in Toxoplasma virulence. Proceedings of the National Academy of Sciences of the United States of America. 108: 9625-30. PMID 21436047 DOI: 10.1073/Pnas.1015980108  0.774
2011 Rosowski EE, Lu D, Julien L, Rodda L, Gaiser RA, Jensen KD, Saeij JP. Strain-specific activation of the NF-kappaB pathway by GRA15, a novel Toxoplasma gondii dense granule protein. The Journal of Experimental Medicine. 208: 195-212. PMID 21199955 DOI: 10.1084/Jem.20100717  0.823
2009 Blader IJ, Saeij JP. Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulence. Apmis : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. 117: 458-76. PMID 19400868 DOI: 10.1111/j.1600-0463.2009.02453.x  0.754
2008 Boyle JP, Saeij JP, Harada SY, Ajioka JW, Boothroyd JC. Expression quantitative trait locus mapping of toxoplasma genes reveals multiple mechanisms for strain-specific differences in gene expression. Eukaryotic Cell. 7: 1403-14. PMID 18552283 DOI: 10.1128/Ec.00073-08  0.714
2008 Saeij JP, Arrizabalaga G, Boothroyd JC. A cluster of four surface antigen genes specifically expressed in bradyzoites, SAG2CDXY, plays an important role in Toxoplasma gondii persistence. Infection and Immunity. 76: 2402-10. PMID 18347037 DOI: 10.1128/Iai.01494-07  0.632
2007 Boyle JP, Saeij JP, Boothroyd JC. Toxoplasma gondii: inconsistent dissemination patterns following oral infection in mice. Experimental Parasitology. 116: 302-5. PMID 17335814 DOI: 10.1016/J.Exppara.2007.01.010  0.704
2007 Saeij JP, Coller S, Boyle JP, Jerome ME, White MW, Boothroyd JC. Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue. Nature. 445: 324-7. PMID 17183270 DOI: 10.1038/Nature05395  0.802
2006 Saeij JP, Boyle JP, Coller S, Taylor S, Sibley LD, Brooke-Powell ET, Ajioka JW, Boothroyd JC. Polymorphic secreted kinases are key virulence factors in toxoplasmosis. Science (New York, N.Y.). 314: 1780-3. PMID 17170306 DOI: 10.1126/Science.1133690  0.813
2006 Boyle JP, Rajasekar B, Saeij JP, Ajioka JW, Berriman M, Paulsen I, Roos DS, Sibley LD, White MW, Boothroyd JC. Just one cross appears capable of dramatically altering the population biology of a eukaryotic pathogen like Toxoplasma gondii. Proceedings of the National Academy of Sciences of the United States of America. 103: 10514-9. PMID 16801557 DOI: 10.1073/Pnas.0510319103  0.771
2006 Boyle JP, Saeij JP, Cleary MD, Boothroyd JC. Analysis of gene expression during development: lessons from the Apicomplexa. Microbes and Infection / Institut Pasteur. 8: 1623-30. PMID 16697685 DOI: 10.1016/J.Micinf.2005.11.017  0.798
2006 Huttenhuis HBT, Taverne-Thiele AJ, Grou CPO, Bergsma J, Saeij JPJ, Nakayasu C, Rombout JHWM. Ontogeny of the common carp (Cyprinus carpio L.) innate immune system Developmental and Comparative Immunology. 30: 557-574. PMID 16406121 DOI: 10.1016/j.dci.2005.08.001  0.343
2005 Saeij JP, Boyle JP, Boothroyd JC. Differences among the three major strains of Toxoplasma gondii and their specific interactions with the infected host. Trends in Parasitology. 21: 476-81. PMID 16098810 DOI: 10.1016/J.Pt.2005.08.001  0.76
2005 Saeij JP, Boyle JP, Grigg ME, Arrizabalaga G, Boothroyd JC. Bioluminescence imaging of Toxoplasma gondii infection in living mice reveals dramatic differences between strains. Infection and Immunity. 73: 695-702. PMID 15664907 DOI: 10.1128/Iai.73.2.695-702.2005  0.731
2004 Joerink M, Saeij JPJ, Stafford JL, Belosevic M, Wiegertjes GF. Animal models for the study of innate immunity: protozoan infections in fish Symposia of the Society For Experimental Biology. PMID 15446445  0.38
2003 Saeij JP, Groeneveld A, Van Rooijen N, Haenen OL, Wiegertjes GF. Minor effect of depletion of resident macrophages from peritoneal cavity on resistance of common carp Cyprinus carpio to blood flagellates. Diseases of Aquatic Organisms. 57: 67-75. PMID 14735923 DOI: 10.3354/dao057067  0.391
2003 Engelsma MY, Stet RJ, Saeij JP, Verburg-van Kemenade BM. Differential expression and haplotypic variation of two interleukin-1beta genes in the common carp (Cyprinus carpio L.). Cytokine. 22: 21-32. PMID 12946102  0.242
2003 Saeij JP, de Vries BJ, Wiegertjes GF. The immune response of carp to Trypanoplasma borreli: kinetics of immune gene expression and polyclonal lymphocyte activation. Developmental and Comparative Immunology. 27: 859-74. PMID 12880636  0.413
2003 Saeij JP, van Muiswinkel WB, van de Meent M, Amaral C, Wiegertjes GF. Different capacities of carp leukocytes to encounter nitric oxide-mediated stress: a role for the intracellular reduced glutathione pool. Developmental and Comparative Immunology. 27: 555-68. PMID 12697312  0.306
2003 Saeij JP, Verburg-van Kemenade LB, van Muiswinkel WB, Wiegertjes GF. Daily handling stress reduces resistance of carp to Trypanoplasma borreli: in vitro modulatory effects of cortisol on leukocyte function and apoptosis. Developmental and Comparative Immunology. 27: 233-45. PMID 12590974  0.317
2003 Saeij JP, Stet RJ, de Vries BJ, van Muiswinkel WB, Wiegertjes GF. Molecular and functional characterization of carp TNF: a link between TNF polymorphism and trypanotolerance? Developmental and Comparative Immunology. 27: 29-41. PMID 12477499  0.297
2002 Saeij J, Muiswinkel WBV, Groeneveld A, Wiegertjes GF. Immune modulation by fish kinetoplastid parasites: a role for nitric oxide. Parasitology. 124: 77-86. PMID 11817378 DOI: 10.1017/S0031182001008915  0.513
2000 Saeij JP, Stet RJ, Groeneveld A, Verburg-van Kemenade LB, van Muiswinkel WB, Wiegertjes GF. Molecular and functional characterization of a fish inducible-type nitric oxide synthase. Immunogenetics. 51: 339-46. PMID 10803847 DOI: 10.1007/s002510050628  0.317
1999 Saeij JP, Wiegertjes GF, Stet RJ. Identification and characterization of a fish natural resistance-associated macrophage protein (NRAMP) cDNA. Immunogenetics. 50: 60-6. PMID 10541807 DOI: 10.1007/s002510050686  0.354
1999 Stet RJ, Kruiswijk CP, Saeij JP, Wiegertjes GF. Major histocompatibility genes in cyprinid fishes: theory and practice. Immunological Reviews. 166: 301-16. PMID 9914921 DOI: 10.1111/j.1600-065x.1998.tb01271.x  0.287
1998 Verburg-Van Kemenade BM, Saeij JP, Flik G, Willems PH. Ca2+ signals during early lymphocyte activation in carp Cyprinus carpio L. The Journal of Experimental Biology. 201: 591-8. PMID 9438833 DOI: 10.1242/jeb.201.4.591  0.259
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