Ian Hickson - Publications

Affiliations: 
University of Copenhagen, København, Denmark 

113 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Martin CA, Sarlós K, Logan CV, Thakur RS, Parry DA, Bizard AH, Leitch A, Cleal L, Ali NS, Al-Owain MA, Allen W, Altmüller J, Aza-Carmona M, Barakat BAY, Barraza-García J, ... ... Hickson ID, et al. Mutations in TOP3A Cause a Bloom Syndrome-like Disorder. American Journal of Human Genetics. 111: 996. PMID 38701747 DOI: 10.1016/j.ajhg.2024.04.008  0.57
2023 Bhowmick R, Hickson ID, Liu Y. Completing genome replication outside of S phase. Molecular Cell. PMID 37716351 DOI: 10.1016/j.molcel.2023.08.023  0.329
2023 Hertz EPT, Vega IA, Kruse T, Wang Y, Hendriks IA, Bizard AH, Eugui-Anta A, Hay RT, Nielsen ML, Nilsson J, Hickson ID, Mailand N. The SUMO-NIP45 pathway processes toxic DNA catenanes to prevent mitotic failure. Nature Structural & Molecular Biology. PMID 37474739 DOI: 10.1038/s41594-023-01045-0  0.331
2022 Bhowmick R, Lerdrup M, Gadi SA, Rossetti GG, Singh MI, Liu Y, Halazonetis TD, Hickson ID. RAD51 protects human cells from transcription-replication conflicts. Molecular Cell. PMID 36002000 DOI: 10.1016/j.molcel.2022.07.010  0.312
2020 Brannvoll A, Xue X, Kwon Y, Kompocholi S, Simonsen AKW, Viswalingam KS, Gonzalez L, Hickson ID, Oestergaard VH, Mankouri HW, Sung P, Lisby M. The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells. Cell Reports. 32: 107849. PMID 32640219 DOI: 10.1016/J.Celrep.2020.107849  0.335
2020 Garribba L, Bjerregaard VA, Gonçalves Dinis MM, Özer Ö, Wu W, Sakellariou D, Pena-Diaz J, Hickson ID, Liu Y. Folate stress induces SLX1- and RAD51-dependent mitotic DNA synthesis at the fragile X locus in human cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 32601218 DOI: 10.1073/pnas.1921219117  0.372
2020 Macheret M, Bhowmick R, Sobkowiak K, Padayachy L, Mailler J, Hickson ID, Halazonetis TD. High-resolution mapping of mitotic DNA synthesis regions and common fragile sites in the human genome through direct sequencing. Cell Research. PMID 32561860 DOI: 10.1038/S41422-020-0358-X  0.342
2020 Carbone M, Arron ST, Beutler B, Bononi A, Cavenee W, Cleaver JE, Croce CM, D'Andrea A, Foulkes WD, Gaudino G, Groden JL, Henske EP, Hickson ID, Hwang PM, Kolodner RD, et al. Tumour predisposition and cancer syndromes as models to study gene-environment interactions. Nature Reviews. Cancer. PMID 32472073 DOI: 10.1038/S41568-020-0265-Y  0.313
2020 Wu W, Bhowmick R, Vogel I, Özer Ö, Ghisays F, Thakur RS, Sanchez de Leon E, Richter PH, Ren L, Petrini JH, Hickson ID, Liu Y. RTEL1 suppresses G-quadruplex-associated R-loops at difficult-to-replicate loci in the human genome. Nature Structural & Molecular Biology. 27: 424-437. PMID 32398827 DOI: 10.1038/S41594-020-0408-6  0.591
2020 Xing M, Zhang F, Liao H, Chen S, Che L, Wang X, Bao Z, Ji F, Chen G, Zhang H, Li W, Chen Z, Liu Y, Hickson ID, Shen H, et al. Replication Stress Induces ATR/CHK1-Dependent Nonrandom Segregation of Damaged Chromosomes. Molecular Cell. PMID 32353258 DOI: 10.1016/j.molcel.2020.04.005  0.365
2020 Wu W, Hickson ID, Liu Y. The prevention and resolution of DNA replication–transcription conflicts in eukaryotic cells Genome Instability & Disease. 1: 114-128. DOI: 10.1007/s42764-020-00012-z  0.34
2019 Achuthankutty D, Thakur RS, Haahr P, Hoffmann S, Drainas AP, Bizard AH, Weischenfeldt J, Hickson ID, Mailand N. Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability. The Journal of Cell Biology. PMID 31615875 DOI: 10.1083/Jcb.201905064  0.617
2019 Sonneville R, Bhowmick R, Hoffmann S, Mailand N, Hickson ID, Labib K. TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication. Elife. 8. PMID 31545170 DOI: 10.7554/Elife.48686  0.344
2019 Taylor AMR, Rothblum-Oviatt C, Ellis NA, Hickson ID, Meyer S, Crawford TO, Smogorzewska A, Pietrucha B, Weemaes C, Stewart GS. Chromosome instability syndromes. Nature Reviews. Disease Primers. 5: 64. PMID 31537806 DOI: 10.1038/s41572-019-0113-0  0.366
2019 Bhowmick R, Thakur RS, Venegas AB, Liu Y, Nilsson J, Barisic M, Hickson ID. The RIF1-PP1 Axis Controls Abscission Timing in Human Cells. Current Biology : Cb. PMID 30905608 DOI: 10.1016/J.Cub.2019.02.037  0.596
2019 Jørgensen SW, Liberti SE, Larsen NB, Lisby M, Mankouri HW, Hickson ID. Esc2 promotes telomere stability in response to DNA replication stress. Nucleic Acids Research. PMID 30838410 DOI: 10.1093/nar/gkz158  0.356
2018 Bjerregaard VA, Garribba L, McMurray CT, Hickson ID, Liu Y. Folate deficiency drives mitotic missegregation of the human locus. Proceedings of the National Academy of Sciences of the United States of America. 115: 13003-13008. PMID 30509972 DOI: 10.1073/pnas.1808377115  0.316
2018 Martin CA, Sarlós K, Logan CV, Thakur RS, Parry DA, Bizard AH, Leitch A, Cleal L, Ali NS, Al-Owain MA, Allen W, Altmüller J, Aza-Carmona M, Barakat BAY, Barraza-García J, ... ... Hickson ID, et al. Mutations in TOP3A Cause a Bloom Syndrome-like Disorder. American Journal of Human Genetics. 103: 456. PMID 30193137 DOI: 10.1016/J.Ajhg.2018.08.012  0.57
2018 Sarlós K, Biebricher AS, Bizard AH, Bakx JAM, Ferreté-Bonastre AG, Modesti M, Paramasivam M, Yao Q, Peterman EJG, Wuite GJL, Hickson ID. Reconstitution of anaphase DNA bridge recognition and disjunction. Nature Structural & Molecular Biology. PMID 30177760 DOI: 10.1038/S41594-018-0123-8  0.324
2018 Martin CA, Sarlós K, Logan CV, Thakur RS, Parry DA, Bizard AH, Leitch A, Cleal L, Ali NS, Al-Owain MA, Allen W, Altmüller J, Aza-Carmona M, Barakat BAY, Barraza-García J, ... ... Hickson ID, et al. Mutations in TOP3A Cause a Bloom Syndrome-like Disorder. American Journal of Human Genetics. PMID 30057030 DOI: 10.1016/J.Ajhg.2018.07.001  0.618
2018 Özer Ö, Hickson ID. Pathways for maintenance of telomeres and common fragile sites during DNA replication stress. Open Biology. 8. PMID 29695617 DOI: 10.1098/rsob.180018  0.342
2018 Zhang BN, Bueno Venegas A, Hickson ID, Chu WK. DNA replication stress and its impact on chromosome segregation and tumorigenesis. Seminars in Cancer Biology. PMID 29692334 DOI: 10.1016/j.semcancer.2018.04.005  0.325
2018 Özer Ö, Bhowmick R, Liu Y, Hickson ID. Human cancer cells utilize mitotic DNA synthesis to resist replication stress at telomeres regardless of their telomere maintenance mechanism. Oncotarget. 9: 15836-15846. PMID 29662610 DOI: 10.18632/oncotarget.24745  0.345
2018 Garribba L, Wu W, Özer Ö, Bhowmick R, Hickson ID, Liu Y. Inducing and Detecting Mitotic DNA Synthesis at Difficult-to-Replicate Loci. Methods in Enzymology. 601: 45-58. PMID 29523241 DOI: 10.1016/bs.mie.2017.11.025  0.368
2017 Sarlós K, Biebricher A, Petermann EJG, Wuite GJL, Hickson ID. Knotty Problems during Mitosis: Mechanistic Insight into the Processing of Ultrafine DNA Bridges in Anaphase. Cold Spring Harbor Symposia On Quantitative Biology. 82: 187-195. PMID 29167280 DOI: 10.1101/Sqb.2017.82.033647  0.337
2017 Larsen NB, Liberti SE, Vogel I, Jørgensen SW, Hickson ID, Mankouri HW. Stalled replication forks generate a distinct mutational signature in yeast. Proceedings of the National Academy of Sciences of the United States of America. PMID 28827358 DOI: 10.1073/pnas.1706640114  0.408
2017 Bhowmick R, Hickson ID. The "enemies within": regions of the genome that are inherently difficult to replicate. F1000research. 6: 666. PMID 28620461 DOI: 10.12688/f1000research.11024.1  0.332
2017 Di Marco S, Hasanova Z, Kanagaraj R, Chappidi N, Altmannova V, Menon S, Sedlackova H, Langhoff J, Surendranath K, Hühn D, Bhowmick R, Marini V, Ferrari S, Hickson ID, Krejci L, et al. RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis. Molecular Cell. 66: 658-671.e8. PMID 28575661 DOI: 10.1016/J.Molcel.2017.05.006  0.355
2017 Natsume T, Nishimura K, Minocherhomji S, Bhowmick R, Hickson ID, Kanemaki MT. Acute inactivation of the replicative helicase in human cells triggers MCM8-9-dependent DNA synthesis. Genes & Development. PMID 28487407 DOI: 10.1101/gad.297663.117  0.354
2016 Bhowmick R, Minocherhomji S, Hickson ID. RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress. Molecular Cell. 64: 1117-1126. PMID 27984745 DOI: 10.1016/j.molcel.2016.10.037  0.32
2016 Nielsen CF, Hickson ID. PICH promotes mitotic chromosome segregation: Identification of a novel role in rDNA disjunction. Cell Cycle (Georgetown, Tex.). 15: 2704-11. PMID 27565185 DOI: 10.1080/15384101.2016.1222336  0.333
2016 Ahuja AK, Jodkowska K, Teloni F, Bizard AH, Zellweger R, Herrador R, Ortega S, Hickson ID, Altmeyer M, Mendez J, Lopes M. A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells. Nature Communications. 7: 10660. PMID 26876348 DOI: 10.1038/Ncomms10660  0.305
2016 Ghamrasni SE, Cardoso R, Li L, Guturi KK, Bjerregaard VA, Liu Y, Venkatesan S, Hande MP, Henderson JT, Sanchez O, Hickson ID, Hakem A, Hakem R. Rad54 and Mus81 cooperation promotes DNA damage repair and restrains chromosome missegregation. Oncogene. PMID 26876210 DOI: 10.1038/onc.2016.16  0.316
2015 Minocherhomji S, Ying S, Bjerregaard VA, Bursomanno S, Aleliunaite A, Wu W, Mankouri HW, Shen H, Liu Y, Hickson ID. Replication stress activates DNA repair synthesis in mitosis. Nature. PMID 26633632 DOI: 10.1038/nature16139  0.348
2015 Kliszczak M, Sedlackova H, Pitchai GP, Streicher WW, Krejci L, Hickson ID. Interaction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cells. Oncotarget. 6: 40464-79. PMID 26588054 DOI: 10.18632/oncotarget.6342  0.308
2015 Xing M, Wang X, Palmai-Pallag T, Shen H, Helleday T, Hickson ID, Ying S. Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response. Oncotarget. PMID 26415217 DOI: 10.18632/oncotarget.5497  0.341
2015 Fugger K, Mistrik M, Neelsen KJ, Yao Q, Zellweger R, Kousholt AN, Haahr P, Chu WK, Bartek J, Lopes M, Hickson ID, Sørensen CS. FBH1 Catalyzes Regression of Stalled Replication Forks. Cell Reports. PMID 25772361 DOI: 10.1016/j.celrep.2015.02.028  0.341
2015 Bursomanno S, McGouran JF, Kessler BM, Hickson ID, Liu Y. Regulation of SUMO2 target proteins by the proteasome in human cells exposed to replication stress. Journal of Proteome Research. 14: 1687-99. PMID 25748227 DOI: 10.1021/pr500997p  0.302
2015 Chu WK, Payne MJ, Beli P, Hanada K, Choudhary C, Hickson ID. FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51. Nature Communications. 6: 5931. PMID 25585578 DOI: 10.1038/Ncomms6931  0.313
2015 Perez-Oliva AB, Lachaud C, Szyniarowski P, Muñoz I, Macartney T, Hickson I, Rouse J, Alessi DR. USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses. The Embo Journal. 34: 326-43. PMID 25538220 DOI: 10.15252/Embj.201489184  0.318
2015 Bursomanno S, Beli P, Khan AM, Minocherhomji S, Wagner SA, Bekker-Jensen S, Mailand N, Choudhary C, Hickson ID, Liu Y. Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells. Dna Repair. 25: 84-96. PMID 25497329 DOI: 10.1016/J.Dnarep.2014.10.011  0.338
2014 Larsen NB, Hickson ID, Mankouri HW. Tus-Ter as a tool to study site-specific DNA replication perturbation in eukaryotes Cell Cycle. 13: 2994-2998. PMID 25486560 DOI: 10.4161/15384101.2014.958912  0.305
2014 Minocherhomji S, Hickson ID. Structure-specific endonucleases: guardians of fragile site stability. Trends in Cell Biology. 24: 321-7. PMID 24361091 DOI: 10.1016/j.tcb.2013.11.007  0.323
2013 Simandlova J, Zagelbaum J, Payne MJ, Chu WK, Shevelev I, Hanada K, Chatterjee S, Reid DA, Liu Y, Janscak P, Rothenberg E, Hickson ID. FBH1 helicase disrupts RAD51 filaments in vitro and modulates homologous recombination in mammalian cells. The Journal of Biological Chemistry. 288: 34168-80. PMID 24108124 DOI: 10.1074/Jbc.M113.484493  0.324
2013 Rosenthal AS, Dexheimer TS, Gileadi O, Nguyen GH, Chu WK, Hickson ID, Jadhav A, Simeonov A, Maloney DJ. Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase. Bioorganic & Medicinal Chemistry Letters. 23: 5660-6. PMID 24012121 DOI: 10.1016/J.Bmcl.2013.08.025  0.35
2013 Fugger K, Chu WK, Haahr P, Kousholt AN, Beck H, Payne MJ, Hanada K, Hickson ID, Sørensen CS. FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress. Nature Communications. 4: 1423. PMID 23361013 DOI: 10.1038/ncomms2395  0.331
2013 Larsen NB, Hickson ID. RecQ Helicases: Conserved Guardians of Genomic Integrity. Advances in Experimental Medicine and Biology. 767: 161-84. PMID 23161011 DOI: 10.1007/978-1-4614-5037-5_8  0.332
2013 Biebricher A, Hirano S, Enzlin J, Peterman E, Hickson I, Wuite GJL. PICH: A DNA Translocase Essential for Resolving Anaphase Bridged DNA Biophysical Journal. 104. DOI: 10.1016/J.Bpj.2012.11.2992  0.425
2011 Eppink B, Tafel AA, Hanada K, van Drunen E, Hickson ID, Essers J, Kanaar R. The response of mammalian cells to UV-light reveals Rad54-dependent and independent pathways of homologous recombination. Dna Repair. 10: 1095-105. PMID 21885354 DOI: 10.1016/j.dnarep.2011.08.006  0.309
2011 Ying S, Hickson ID. Fanconi anaemia proteins are associated with sister chromatid bridging in mitosis. International Journal of Hematology. 93: 440-445. PMID 21472397 DOI: 10.1007/s12185-011-0818-7  0.346
2011 Lukas C, Savic V, Bekker-Jensen S, Doil C, Neumann B, Pedersen RS, Grøfte M, Chan KL, Hickson ID, Bartek J, Lukas J. 53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress. Nature Cell Biology. 13: 243-53. PMID 21317883 DOI: 10.1038/Ncb2201  0.314
2011 Suhasini AN, Rawtani NA, Wu Y, Sommers JA, Sharma S, Mosedale G, North PS, Cantor SB, Hickson ID, Brosh RM. Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome. The Embo Journal. 30: 692-705. PMID 21240188 DOI: 10.1038/emboj.2010.362  0.373
2010 Chu WK, Hanada K, Kanaar R, Hickson ID. BLM has early and late functions in homologous recombination repair in mouse embryonic stem cells. Oncogene. 29: 4705-14. PMID 20531307 DOI: 10.1038/Onc.2010.214  0.447
2010 Ashton TM, Hickson ID. Yeast as a model system to study RecQ helicase function Dna Repair. 9: 303-314. PMID 20071248 DOI: 10.1016/j.dnarep.2009.12.007  0.32
2009 Hemphill AW, Akkari Y, Newell AH, Schultz RA, Grompe M, North PS, Hickson ID, Jakobs PM, Rennie S, Pauw D, Hejna J, Olson SB, Moses RE. Topo IIIalpha and BLM act within the Fanconi anemia pathway in response to DNA-crosslinking agents. Cytogenetic and Genome Research. 125: 165-75. PMID 19738377 DOI: 10.1159/000230001  0.328
2009 Chu WK, Hickson ID. RecQ helicases: multifunctional genome caretakers. Nature Reviews. Cancer. 9: 644-54. PMID 19657341 DOI: 10.1038/nrc2682  0.312
2009 Chan KL, Palmai-Pallag T, Ying S, Hickson ID. Replication stress induces sister-chromatid bridging at fragile site loci in mitosis. Nature Cell Biology. 11: 753-60. PMID 19465922 DOI: 10.1038/ncb1882  0.34
2009 Payne M, Hickson ID. Genomic instability and cancer: lessons from analysis of Bloom's syndrome. Biochemical Society Transactions. 37: 553-9. PMID 19442250 DOI: 10.1042/BST0370553  0.326
2008 London TB, Barber LJ, Mosedale G, Kelly GP, Balasubramanian S, Hickson ID, Boulton SJ, Hiom K. FANCJ is a structure-specific DNA helicase associated with the maintenance of genomic G/C tracts. The Journal of Biological Chemistry. 283: 36132-9. PMID 18978354 DOI: 10.1074/Jbc.M808152200  0.304
2008 Xu D, Guo R, Sobeck A, Bachrati CZ, Yang J, Enomoto T, Brown GW, Hoatlin ME, Hickson ID, Wang W. RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability. Genes & Development. 22: 2843-55. PMID 18923082 DOI: 10.1101/Gad.1708608  0.325
2008 Selak N, Bachrati CZ, Shevelev I, Dietschy T, van Loon B, Jacob A, Hübscher U, Hoheisel JD, Hickson ID, Stagljar I. The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase delta. Nucleic Acids Research. 36: 5166-79. PMID 18682526 DOI: 10.1093/nar/gkn498  0.347
2008 Popuri V, Bachrati CZ, Muzzolini L, Mosedale G, Costantini S, Giacomini E, Hickson ID, Vindigni A. The Human RecQ helicases, BLM and RECQ1, display distinct DNA substrate specificities. The Journal of Biological Chemistry. 283: 17766-76. PMID 18448429 DOI: 10.1074/jbc.M709749200  0.308
2008 Bachrati CZ, Hickson ID. RecQ helicases: guardian angels of the DNA replication fork. Chromosoma. 117: 219-33. PMID 18188578 DOI: 10.1007/s00412-007-0142-4  0.337
2007 Mankouri HW, Hickson ID. The RecQ helicase-topoisomerase III-Rmi1 complex: a DNA structure-specific 'dissolvasome'? Trends in Biochemical Sciences. 32: 538-46. PMID 17980605 DOI: 10.1016/J.TIBS.2007.09.009  0.301
2007 Hanada K, Budzowska M, Davies SL, van Drunen E, Onizawa H, Beverloo HB, Maas A, Essers J, Hickson ID, Kanaar R. The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks. Nature Structural & Molecular Biology. 14: 1096-104. PMID 17934473 DOI: 10.1038/nsmb1313  0.326
2007 Rao VA, Conti C, Guirouilh-Barbat J, Nakamura A, Miao ZH, Davies SL, Saccá B, Hickson ID, Bensimon A, Pommier Y. Endogenous γ-H2AX-ATM-Chk2 checkpoint activation in Bloom's syndrome helicase-deficient cells is related to DNA replication arrested forks Molecular Cancer Research. 5: 713-724. PMID 17634426 DOI: 10.1158/1541-7786.MCR-07-0028  0.367
2007 Davies SL, North PS, Hickson ID. Role for BLM in replication-fork restart and suppression of origin firing after replicative stress Nature Structural and Molecular Biology. 14: 677-679. PMID 17603497 DOI: 10.1038/nsmb1267  0.316
2007 Chan KL, North PS, Hickson ID. BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges. The Embo Journal. 26: 3397-409. PMID 17599064 DOI: 10.1038/sj.emboj.7601777  0.336
2006 Mankouri HW, Hickson ID. Top3 processes recombination intermediates and modulates checkpoint activity after DNA damage. Molecular Biology of the Cell. 17: 4473-83. PMID 16899506 DOI: 10.1091/MBC.E06-06-0516  0.316
2006 Bachrati CZ, Hickson ID. Analysis of the DNA unwinding activity of RecQ family helicases. Methods in Enzymology. 409: 86-100. PMID 16793396 DOI: 10.1016/S0076-6879(05)09005-1  0.336
2006 Ralf C, Hickson ID, Wu L. The Bloom's syndrome helicase can promote the regression of a model replication fork. The Journal of Biological Chemistry. 281: 22839-46. PMID 16766518 DOI: 10.1074/jbc.M604268200  0.348
2006 Wu L, Bachrati CZ, Ou J, Xu C, Yin J, Chang M, Wang W, Li L, Brown GW, Hickson ID. BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates. Proceedings of the National Academy of Sciences of the United States of America. 103: 4068-73. PMID 16537486 DOI: 10.1073/Pnas.0508295103  0.336
2006 Spillare EA, Wang XW, von Kobbe C, Bohr VA, Hickson ID, Harris CC. Redundancy of DNA helicases in p53-mediated apoptosis. Oncogene. 25: 2119-23. PMID 16288211 DOI: 10.1038/sj.onc.1209242  0.322
2005 Win TZ, Mankouri HW, Hickson ID, Wang SW. A role for the fission yeast Rqh1 helicase in chromosome segregation. Journal of Cell Science. 118: 5777-84. PMID 16303848 DOI: 10.1242/Jcs.02694  0.386
2005 Cheok CF, Bachrati CZ, Chan KL, Ralf C, Wu L, Hickson ID. Roles of the Bloom's syndrome helicase in the maintenance of genome stability. Biochemical Society Transactions. 33: 1456-9. PMID 16246145 DOI: 10.1042/BST20051456  0.398
2005 Rao VA, Fan AM, Meng L, Doe CF, North PS, Hickson ID, Pommier Y. Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage. Molecular and Cellular Biology. 25: 8925-37. PMID 16199871 DOI: 10.1128/MCB.25.20.8925-8937.2005  0.344
2005 Opresko PL, Mason PA, Podell ER, Lei M, Hickson ID, Cech TR, Bohr VA. POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates. The Journal of Biological Chemistry. 280: 32069-80. PMID 16030011 DOI: 10.1074/Jbc.M505211200  0.351
2005 Cheok CF, Wu L, Garcia PL, Janscak P, Hickson ID. The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA. Nucleic Acids Research. 33: 3932-41. PMID 16024743 DOI: 10.1093/Nar/Gki712  0.341
2005 Plummer ER, Middleton MR, Jones C, Olsen A, Hickson I, McHugh P, Margison GP, McGown G, Thorncroft M, Watson AJ, Boddy AV, Calvert AH, Harris AL, Newell DR, Curtin NJ. Temozolomide pharmacodynamics in patients with metastatic melanoma: dna damage and activity of repair enzymes O6-alkylguanine alkyltransferase and poly(ADP-ribose) polymerase-1. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 3402-9. PMID 15867241 DOI: 10.1158/1078-0432.Ccr-04-2353  0.372
2005 Farmer H, McCabe N, Lord CJ, Tutt AN, Johnson DA, Richardson TB, Santarosa M, Dillon KJ, Hickson I, Knights C, Martin NM, Jackson SP, Smith GC, Ashworth A. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature. 434: 917-21. PMID 15829967 DOI: 10.1038/nature03445  0.333
2004 Win TZ, Goodwin A, Hickson ID, Norbury CJ, Wang SW. Requirement for Schizosaccharomyces pombe Top3 in the maintenance of chromosome integrity. Journal of Cell Science. 117: 4769-78. PMID 15340008 DOI: 10.1242/Jcs.01351  0.304
2004 Jiao R, Bachrati CZ, Pedrazzi G, Kuster P, Petkovic M, Li JL, Egli D, Hickson ID, Stagljar I. Physical and functional interaction between the Bloom's syndrome gene product and the largest subunit of chromatin assembly factor 1. Molecular and Cellular Biology. 24: 4710-9. PMID 15143166 DOI: 10.1128/Mcb.24.11.4710-4719.2004  0.353
2004 Yang Q, Zhang R, Wang XW, Linke SP, Sengupta S, Hickson ID, Pedrazzi G, Perrera C, Stagljar I, Littman SJ, Modrich P, Harris CC. The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase Oncogene. 23: 3749-3756. PMID 15064730 DOI: 10.1038/Sj.Onc.1207462  0.31
2004 Davies SL, North PS, Dart A, Lakin ND, Hickson ID. Phosphorylation of the Bloom's Syndrome Helicase and Its Role in Recovery from S-Phase Arrest Molecular and Cellular Biology. 24: 1279-1291. PMID 14729972 DOI: 10.1128/MCB.24.3.1279-1291.2004  0.357
2004 Wu L, Hickson ID. The Bloom's syndrome helicase suppresses crossing over during homologous recombination. Nature. 426: 870-4. PMID 14685245 DOI: 10.1038/nature02253  0.382
2003 Sharma S, Sommers JA, Wu L, Bohr VA, Hickson ID, Brosh RM. Stimulation of flap endonuclease-1 by the Bloom's syndrome protein. The Journal of Biological Chemistry. 279: 9847-56. PMID 14688284 DOI: 10.1074/JBC.M309898200  0.364
2003 Rassool FV, North PS, Mufti GJ, Hickson ID. Constitutive DNA damage is linked to DNA replication abnormalities in Bloom's syndrome cells. Oncogene. 22: 8749-57. PMID 14647470 DOI: 10.1038/sj.onc.1206970  0.388
2003 Braybrooke JP, Li JL, Wu L, Caple F, Benson FE, Hickson ID. Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D). The Journal of Biological Chemistry. 278: 48357-66. PMID 12975363 DOI: 10.1074/jbc.M308838200  0.327
2003 Pedrazzi G, Bachrati CZ, Selak N, Studer I, Petkovic M, Hickson ID, Jiricny J, Stagljar I. The Bloom's syndrome helicase interacts directly with the human DNA mismatch repair protein hMSH6. Biological Chemistry. 384: 1155-64. PMID 12974384 DOI: 10.1515/BC.2003.128  0.363
2003 Khakhar RR, Cobb JA, Bjergbaek L, Hickson ID, Gasser SM. RecQ helicases: multiple roles in genome maintenance. Trends in Cell Biology. 13: 493-501. PMID 12946629 DOI: 10.1016/S0962-8924(03)00171-5  0.301
2003 Bachrati CZ, Hickson ID. RecQ helicases: suppressors of tumorigenesis and premature aging. The Biochemical Journal. 374: 577-606. PMID 12803543 DOI: 10.1042/BJ20030491  0.336
2003 Hickson ID. RecQ helicases: caretakers of the genome. Nature Reviews. Cancer. 3: 169-78. PMID 12612652 DOI: 10.1038/nrc1012  0.357
2003 Mohaghegh P, Hickson ID. The Bloom's syndrome helicase: keeping cancer at bay. Biologist (London, England). 50: 29-33. PMID 12586954  0.309
2002 Wu L, Hickson ID. The Bloom's syndrome helicase stimulates the activity of human topoisomerase IIIalpha. Nucleic Acids Research. 30: 4823-9. PMID 12433984 DOI: 10.1093/NAR/GKF611  0.342
2002 Wu L, Hickson ID. RecQ helicases and cellular responses to DNA damage. Mutation Research. 509: 35-47. PMID 12427530 DOI: 10.1016/S0027-5107(02)00225-7  0.346
2002 Gaymes TJ, North PS, Brady N, Hickson ID, Mufti GJ, Rassool FV. Increased error-prone non homologous DNA end-joining--a proposed mechanism of chromosomal instability in Bloom's syndrome. Oncogene. 21: 2525-33. PMID 11971187 DOI: 10.1038/sj.onc.1205331  0.345
2001 Li JL, Harrison RJ, Reszka AP, Brosh RM, Bohr VA, Neidle S, Hickson ID. Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands. Biochemistry. 40: 15194-202. PMID 11735402 DOI: 10.1021/Bi011067H  0.308
2001 Pedrazzi G, Perrera C, Blaser H, Kuster P, Marra G, Davies SL, Ryu GH, Freire R, Hickson ID, Jiricny J, Stagljar I. Direct association of Bloom's syndrome gene product with the human mismatch repair protein MLH1 Nucleic Acids Research. 29: 4378-4386. PMID 11691925 DOI: 10.1093/NAR/29.21.4378  0.326
2001 Wu L, Hickson ID. RecQ helicases and topoisomerases: components of a conserved complex for the regulation of genetic recombination. Cellular and Molecular Life Sciences : Cmls. 58: 894-901. PMID 11497238 DOI: 10.1007/PL00000909  0.31
2001 Wang SW, Goodwin A, Hickson ID, Norbury CJ. Involvement of Schizosaccharomyces pombe Srs2 in cellular responses to DNA damage. Nucleic Acids Research. 29: 2963-72. PMID 11452021 DOI: 10.1093/Nar/29.14.2963  0.335
2001 Mohaghegh P, Karow JK, Brosh RM, Bohr VA, Hickson ID. The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases. Nucleic Acids Research. 29: 2843-9. PMID 11433031 DOI: 10.1093/NAR/29.13.2843  0.304
2001 Wu L, Davies SL, Levitt NC, Hickson ID. Potential Role for the BLM Helicase in Recombinational Repair via a Conserved Interaction with RAD51 Journal of Biological Chemistry. 276: 19375-19381. PMID 11278509 DOI: 10.1074/jbc.M009471200  0.356
2001 Mohaghegh P, Hickson ID. DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders. Human Molecular Genetics. 10: 741-6. PMID 11257107 DOI: 10.1093/HMG/10.7.741  0.354
2001 Constantinou A, Tarsounas M, Karow JK, Brosh RM, Bohr VA, Hickson ID, West SC. Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest. Embo Reports. 1: 80-4. PMID 11256630 DOI: 10.1093/Embo-Reports/Kvd004  0.338
2000 Brosh RM, Majumdar A, Desai S, Hickson ID, Bohr VA, Seidman MM. Unwinding of a DNA triple helix by the Werner and Bloom syndrome helicases. The Journal of Biological Chemistry. 276: 3024-30. PMID 11110789 DOI: 10.1074/JBC.M006784200  0.335
2000 Braybrooke JP, Spink KG, Thacker J, Hickson ID. The RAD51 family member, RAD51L3, is a DNA-stimulated ATPase that forms a complex with XRCC2 Journal of Biological Chemistry. 275: 29100-29106. PMID 10871607 DOI: 10.1074/JBC.M002075200  0.312
2000 Brosh RM, Karow JK, White EJ, Shaw ND, Hickson ID, Bohr VA. Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs. Nucleic Acids Research. 28: 2420-30. PMID 10871376 DOI: 10.1093/NAR/28.12.2420  0.367
2000 Brosh RM, Li JL, Kenny MK, Karow JK, Cooper MP, Kureekattil RP, Hickson ID, Bohr VA. Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity. The Journal of Biological Chemistry. 275: 23500-8. PMID 10825162 DOI: 10.1074/jbc.M001557200  0.316
2000 Karow JK, Constantinou A, Li JL, West SC, Hickson ID. The Bloom's syndrome gene product promotes branch migration of holliday junctions. Proceedings of the National Academy of Sciences of the United States of America. 97: 6504-8. PMID 10823897 DOI: 10.1073/Pnas.100448097  0.382
1999 Chakraverty RK, Hickson ID. Defending genome integrity during DNA replication: a proposed role for RecQ family helicases. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 21: 286-94. PMID 10377891 DOI: 10.1002/(SICI)1521-1878(199904)21:4<286::AID-BIES4>3.0.CO;2-Z  0.373
1998 Sun H, Karow JK, Hickson ID, Maizels N. The Bloom's syndrome helicase unwinds G4 DNA. The Journal of Biological Chemistry. 273: 27587-92. PMID 9765292 DOI: 10.1074/Jbc.273.42.27587  0.306
1998 Karow JK, Chakraverty RK, Hickson ID. The Bloom's syndrome gene product is a 3'-5' DNA helicase. The Journal of Biological Chemistry. 272: 30611-4. PMID 9388193 DOI: 10.1074/jbc.272.49.30611  0.344
1997 Rafferty JA, Wibley JEA, Speers P, Hickson I, Margison GP, Moody PCE, Douglas KT. The potential role of glycine-160 of human O6-alkylguanine-DNA alkyltransferase in reaction with O6-benzylguanine as determined by site-directed mutagenesis and molecular modelling comparisons Biochimica Et Biophysica Acta. 1342: 90-102. PMID 9366274 DOI: 10.1016/S0167-4838(97)00095-2  0.318
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