| Year |
Citation |
Score |
| 2024 |
Hoekstra ME, Slagter M, Urbanus J, Toebes M, Slingerland N, de Rink I, Kluin RJC, Nieuwland M, Kerkhoven R, Wessels LFA, Schumacher TN. Distinct spatiotemporal dynamics of CD8 T cell-derived cytokines in the tumor microenvironment. Cancer Cell. 42: 157-167.e9. PMID 38194914 DOI: 10.1016/j.ccell.2023.12.010 |
0.384 |
|
| 2023 |
Kenski JCN, Huang X, Vredevoogd DW, de Bruijn B, Traets JJH, Ibáñez-Molero S, Schieven SM, van Vliet A, Krijgsman O, Kuilman T, Pozniak J, Loayza-Puch F, Terry AM, Müller J, Logtenberg MEW, ... ... Schumacher TN, et al. An adverse tumor-protective effect of IDO1 inhibition. Cell Reports. Medicine. 4: 100941. PMID 36812891 DOI: 10.1016/j.xcrm.2023.100941 |
0.403 |
|
| 2023 |
de Vries NL, van de Haar J, Veninga V, Chalabi M, Ijsselsteijn ME, van der Ploeg M, van den Bulk J, Ruano D, van den Berg JG, Haanen JB, Zeverijn LJ, Geurts BS, de Wit GF, Battaglia TW, Gelderblom H, ... ... Schumacher TN, et al. γδ T cells are effectors of immunotherapy in cancers with HLA class I defects. Nature. 613: 743-750. PMID 36631610 DOI: 10.1038/s41586-022-05593-1 |
0.374 |
|
| 2023 |
Cattaneo CM, Battaglia T, Urbanus J, Moravec Z, Voogd R, de Groot R, Hartemink KJ, Haanen JBAG, Voest EE, Schumacher TN, Scheper W. Identification of patient-specific CD4 and CD8 T cell neoantigens through HLA-unbiased genetic screens. Nature Biotechnology. PMID 36593398 DOI: 10.1038/s41587-022-01547-0 |
0.419 |
|
| 2022 |
Santegoets SJ, Welters MJP, Schrikkema DS, Freriks MR, Kok H, Weissbrich B, van den Branden A, Linnemann C, Schumacher TN, Adhikary S, Bendle G, van der Burg SH. The common HLA class I-restricted tumor-infiltrating T cell response in HPV16-induced cancer. Cancer Immunology, Immunotherapy : Cii. PMID 36526910 DOI: 10.1007/s00262-022-03350-x |
0.448 |
|
| 2022 |
Haanen JB, Schumacher TN. Next generation T cell therapies for solid cancers. Med (New York, N.Y.). 3: 645-647. PMID 36242997 DOI: 10.1016/j.medj.2022.09.008 |
0.367 |
|
| 2022 |
Bresser K, Kok L, Swain AC, King LA, Jacobs L, Weber TS, Perié L, Duffy KR, de Boer RJ, Scheeren FA, Schumacher TN. Author Correction: Replicative history marks transcriptional and functional disparity in the CD8 T cell memory pool. Nature Immunology. PMID 35606445 DOI: 10.1038/s41590-022-01246-7 |
0.322 |
|
| 2022 |
Bresser K, Kok L, Swain AC, King LA, Jacobs L, Weber TS, Perié L, Duffy KR, de Boer RJ, Scheeren FA, Schumacher TN. Replicative history marks transcriptional and functional disparity in the CD8 T cell memory pool. Nature Immunology. PMID 35393592 DOI: 10.1038/s41590-022-01171-9 |
0.459 |
|
| 2021 |
van der Leun AM, Schumacher TN. An atlas of intratumoral T cells. Science (New York, N.Y.). 374: 1446-1447. PMID 34914514 DOI: 10.1126/science.abm9244 |
0.412 |
|
| 2021 |
Ali M, Giannakopoulou E, Li Y, Lehander M, Virding Culleton S, Yang W, Knetter C, Odabasi MC, Bollineni RC, Yang X, Foldvari Z, Böschen ML, Taraldsrud E, Strønen E, Toebes M, ... ... Schumacher TN, et al. T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes. Nature Biotechnology. PMID 34873326 DOI: 10.1038/s41587-021-01089-x |
0.455 |
|
| 2021 |
Matas-Rico E, Frijlink E, van der Haar Àvila I, Menegakis A, van Zon M, Morris AJ, Koster J, Salgado-Polo F, de Kivit S, Lança T, Mazzocca A, Johnson Z, Haanen J, Schumacher TN, Perrakis A, et al. Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8 T cells. Cell Reports. 37: 110013. PMID 34788605 DOI: 10.1016/j.celrep.2021.110013 |
0.413 |
|
| 2021 |
Gangaev A, Rozeman EA, Rohaan MW, Isaeva OI, Philips D, Patiwael S, van den Berg JH, Ribas A, Schadendorf D, Schilling B, Schumacher TN, Blank CU, Haanen JBAG, Kvistborg P. Differential effects of PD-1 and CTLA-4 blockade on the melanoma-reactive CD8 T cell response. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34670835 DOI: 10.1073/pnas.2102849118 |
0.36 |
|
| 2021 |
Sahillioglu AC, Schumacher TN. Multimodular Optimization of Chemically Regulated T Cell Switches Demonstrates Flexible and Interchangeable Nature of Immune Cell Signaling Domains. Human Gene Therapy. 32: 1029-1043. PMID 34662227 DOI: 10.1089/hum.2021.148 |
0.345 |
|
| 2021 |
Kok L, Masopust D, Schumacher TN. The precursors of CD8 tissue resident memory T cells: from lymphoid organs to infected tissues. Nature Reviews. Immunology. PMID 34480118 DOI: 10.1038/s41577-021-00590-3 |
0.436 |
|
| 2021 |
Sahillioglu AC, Schumacher TN. Safety switches for adoptive cell therapy. Current Opinion in Immunology. PMID 34389174 DOI: 10.1016/j.coi.2021.07.002 |
0.344 |
|
| 2021 |
Sahillioglu AC, Toebes M, Apriamashvili G, Gomez R, Schumacher TN. CRASH-IT switch enables reversible and dose-dependent control of TCR and CAR T-cell function. Cancer Immunology Research. PMID 34193461 DOI: 10.1158/2326-6066.CIR-21-0095 |
0.383 |
|
| 2021 |
Gangaev A, Ketelaars SLC, Isaeva OI, Patiwael S, Dopler A, Hoefakker K, De Biasi S, Gibellini L, Mussini C, Guaraldi G, Girardis M, Ormeno CMPT, Hekking PJM, Lardy NM, Toebes M, ... ... Schumacher TN, et al. Identification and characterization of a SARS-CoV-2 specific CD8 T cell response with immunodominant features. Nature Communications. 12: 2593. PMID 33972535 DOI: 10.1038/s41467-021-22811-y |
0.469 |
|
| 2021 |
Hoekstra ME, Vijver SV, Schumacher TN. Modulation of the tumor micro-environment by CD8 T cell-derived cytokines. Current Opinion in Immunology. 69: 65-71. PMID 33862306 DOI: 10.1016/j.coi.2021.03.016 |
0.407 |
|
| 2020 |
Kok L, Dijkgraaf FE, Urbanus J, Bresser K, Vredevoogd DW, Cardoso RF, Perié L, Beltman JB, Schumacher TN. A committed tissue-resident memory T cell precursor within the circulating CD8+ effector T cell pool. The Journal of Experimental Medicine. 217. PMID 32728699 DOI: 10.1084/jem.20191711 |
0.455 |
|
| 2020 |
Logtenberg MEW, Scheeren FA, Schumacher TN. The CD47-SIRPα Immune Checkpoint. Immunity. 52: 742-752. PMID 32433947 DOI: 10.1016/j.immuni.2020.04.011 |
0.302 |
|
| 2020 |
Li H, van der Leun AM, Yofe I, Lubling Y, Gelbard-Solodkin D, van Akkooi ACJ, van den Braber M, Rozeman EA, Haanen JBAG, Blank CU, Horlings HM, David E, Baran Y, Bercovich A, Lifshitz A, ... Schumacher TN, et al. Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma. Cell. 181: 747. PMID 32359441 DOI: 10.1016/j.cell.2020.04.017 |
0.358 |
|
| 2020 |
Prota G, Gileadi U, Rei M, Lechuga-Vieco AV, Chen JL, Galiani S, Bedard M, Lau VWC, Fanchi LF, Artibani M, Hu Z, Gordon S, Rehwinkel J, Enríquez JA, Ahmed AA, ... Schumacher TN, et al. Enhanced immunogenicity of mitochondrial-localized proteins in cancer cells. Cancer Immunology Research. PMID 32205315 DOI: 10.1158/2326-6066.Cir-19-0467 |
0.307 |
|
| 2020 |
Zenke S, Palm MM, Braun J, Gavrilov A, Meiser P, Böttcher JP, Beyersdorf N, Ehl S, Gerard A, Lämmermann T, Schumacher TN, Beltman JB, Rohr JC. Quorum Regulation via Nested Antagonistic Feedback Circuits Mediated by the Receptors CD28 and CTLA-4 Confers Robustness to T Cell Population Dynamics. Immunity. 52: 313-327.e7. PMID 32049052 DOI: 10.1016/j.immuni.2020.01.018 |
0.414 |
|
| 2020 |
van der Leun AM, Thommen DS, Schumacher TN. CD8 T cell states in human cancer: insights from single-cell analysis. Nature Reviews. Cancer. 20: 218-232. PMID 32024970 DOI: 10.1038/s41568-019-0235-4 |
0.456 |
|
| 2020 |
Slagter M, Rozeman EA, Ding H, Versluis JM, Valenti M, Peters D, Broeks A, Rooijen Cv, Horlings H, Haanen JBAG, Hooijberg E, Wessels LFA, Blank CU, Schumacher TN. Spatial proximity of CD8 T cells to tumor cells as an independent biomarker for response to anti-PD-1 therapy. Journal of Clinical Oncology. 38: 10038-10038. DOI: 10.1200/jco.2020.38.15_suppl.10038 |
0.428 |
|
| 2020 |
Scheper W, Merino-Rodriguez E, Braster R, Sitters G, Oswald F, Schumacher T, Candelli A. Measuring T-cell avidity and enrichment using an acoustic force-based technology The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.04023 |
0.439 |
|
| 2019 |
Cattaneo CM, Dijkstra KK, Fanchi LF, Kelderman S, Kaing S, van Rooij N, van den Brink S, Schumacher TN, Voest EE. Tumor organoid-T-cell coculture systems. Nature Protocols. PMID 31853056 DOI: 10.1038/s41596-019-0232-9 |
0.388 |
|
| 2019 |
Blank CU, Haining WN, Held W, Hogan PG, Kallies A, Lugli E, Lynn RC, Philip M, Rao A, Restifo NP, Schietinger A, Schumacher TN, Schwartzberg PL, Sharpe AH, Speiser DE, et al. Defining 'T cell exhaustion'. Nature Reviews. Immunology. PMID 31570879 DOI: 10.1038/S41577-019-0221-9 |
0.425 |
|
| 2019 |
Dijkgraaf FE, Matos TR, Hoogenboezem M, Toebes M, Vredevoogd DW, Mertz M, van den Broek B, Song JY, Teunissen MBM, Luiten RM, Beltman JB, Schumacher TN. Tissue patrol by resident memory CD8 T cells in human skin. Nature Immunology. PMID 31110315 DOI: 10.1038/s41590-019-0404-3 |
0.412 |
|
| 2019 |
Ali M, Foldvari Z, Giannakopoulou E, Böschen ML, Strønen E, Yang W, Toebes M, Schubert B, Kohlbacher O, Schumacher TN, Olweus J. Induction of neoantigen-reactive T cells from healthy donors. Nature Protocols. PMID 31101906 DOI: 10.1038/S41596-019-0170-6 |
0.479 |
|
| 2019 |
Di Lorenzo B, Simões AE, Caiado F, Tieppo P, Correia DV, Carvalho T, da Silva MG, Déchanet-Merville J, Schumacher TN, Prinz I, Norell H, Ravens S, Vermijlen D, Silva-Santos B. Broad Cytotoxic Targeting of Acute Myeloid Leukemia by Polyclonal Delta One T Cells. Cancer Immunology Research. PMID 30894378 DOI: 10.1158/2326-6066.CIR-18-0647 |
0.387 |
|
| 2019 |
Logtenberg MEW, Jansen JHM, Raaben M, Toebes M, Franke K, Brandsma AM, Matlung HL, Fauster A, Gomez-Eerland R, Bakker NAM, van der Schot S, Marijt KA, Verdoes M, Haanen JBAG, van den Berg JH, ... ... Schumacher TN, et al. Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy. Nature Medicine. 25: 612-619. PMID 30833751 DOI: 10.1038/S41591-019-0356-Z |
0.599 |
|
| 2019 |
Mezzadra R, de Bruijn M, Jae LT, Gomez-Eerland R, Duursma A, Scheeren FA, Brummelkamp TR, Schumacher TN. SLFN11 can sensitize tumor cells towards IFN-γ-mediated T cell killing. Plos One. 14: e0212053. PMID 30753225 DOI: 10.1371/journal.pone.0212053 |
0.376 |
|
| 2019 |
Schumacher TN, Scheper W, Kvistborg P. Cancer Neoantigens. Annual Review of Immunology. 37: 173-200. PMID 30550719 DOI: 10.1146/annurev-immunol-042617-053402 |
0.362 |
|
| 2019 |
Raja A, Scheper W, Merino E, Braster R, Sitter G, Oswald F, Schumacher T, Candelli A, Anderson L. Abstract 5153: Measuring T-cell avidity and enrichment using an acoustic force based technology Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-5153 |
0.394 |
|
| 2018 |
Lampen MH, Uchtenhagen H, Blom K, Varnaitė R, Pakalniene J, Dailidyte L, Wälchli S, Lindquist L, Mickiene A, Michaëlsson J, Schumacher TN, Ljunggren HG, Sandberg JK, Achour A, Gredmark-Russ S. Breadth and Dynamics of HLA-A2- and HLA-B7-Restricted CD8 T Cell Responses against Nonstructural Viral Proteins in Acute Human Tick-Borne Encephalitis Virus Infection. Immunohorizons. 2: 172-184. PMID 31022685 DOI: 10.4049/immunohorizons.1800029 |
0.396 |
|
| 2018 |
Li H, van der Leun AM, Yofe I, Lubling Y, Gelbard-Solodkin D, van Akkooi ACJ, van den Braber M, Rozeman EA, Haanen JBAG, Blank CU, Horlings HM, David E, Baran Y, Bercovich A, Lifshitz A, ... Schumacher TN, et al. Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma. Cell. PMID 30595452 DOI: 10.1016/j.cell.2018.11.043 |
0.452 |
|
| 2018 |
Scheper W, Kelderman S, Fanchi LF, Linnemann C, Bendle G, de Rooij MAJ, Hirt C, Mezzadra R, Slagter M, Dijkstra K, Kluin RJC, Snaebjornsson P, Milne K, Nelson BH, Zijlmans H, ... ... Schumacher TN, et al. Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers. Nature Medicine. PMID 30510250 DOI: 10.1038/s41591-018-0266-5 |
0.416 |
|
| 2018 |
Dijkstra KK, Cattaneo CM, Weeber F, Chalabi M, van de Haar J, Fanchi LF, Slagter M, van der Velden DL, Kaing S, Kelderman S, van Rooij N, van Leerdam ME, Depla A, Smit EF, Hartemink KJ, ... ... Schumacher TN, et al. Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids. Cell. PMID 30100188 DOI: 10.1016/J.Cell.2018.07.009 |
0.365 |
|
| 2018 |
Thommen DS, Schumacher TN. T Cell Dysfunction in Cancer. Cancer Cell. 33: 547-562. PMID 29634943 DOI: 10.1016/j.ccell.2018.03.012 |
0.396 |
|
| 2018 |
Yofe I, Li H, Leun Avd, Yaniv L, Weiner A, Akkooi Av, Tanay A, Schumacher T, Amit I. Abstract B54: Dissecting immune cell heterogeneity in human cancer by single-cell RNA-sequencing Cancer Immunology Research. 6. DOI: 10.1158/2326-6074.Tumimm17-B54 |
0.494 |
|
| 2018 |
Schumacher T. Abstract KN02: Keynote Lecture: T-cell recognition of human cancer Molecular Cancer Therapeutics. 17. DOI: 10.1158/1535-7163.Targ-17-Kn02 |
0.412 |
|
| 2017 |
Gee MH, Han A, Lofgren SM, Beausang JF, Mendoza JL, Birnbaum ME, Bethune MT, Fischer S, Yang X, Gomez-Eerland R, Bingham DB, Sibener LV, Fernandes RA, Velasco A, Baltimore D, ... Schumacher TN, et al. Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes. Cell. PMID 29275860 DOI: 10.1016/J.Cell.2017.11.043 |
0.42 |
|
| 2017 |
Regev A, Teichmann SA, Lander ES, Amit I, Benoist C, Birney E, Bodenmiller B, Campbell PJ, Carninci P, Clatworthy M, Clevers H, Deplancke B, Dunham I, Eberwine J, Eils R, ... ... Schumacher TN, et al. Science Forum: The Human Cell Atlas. Elife. 6. PMID 29206104 DOI: 10.7554/Elife.27041 |
0.465 |
|
| 2017 |
Cossarizza A, Chang HD, Radbruch A, Andrä I, Annunziato F, Bacher P, Barnaba V, Battistini L, Bauer WM, Baumgart S, Becher B, Beisker W, Berek C, Blanco A, Borsellino G, ... ... Schumacher T, et al. Guidelines for the use of flow cytometry and cell sorting in immunological studies. European Journal of Immunology. 47: 1584-1797. PMID 29023707 DOI: 10.1002/Eji.201646632 |
0.391 |
|
| 2017 |
Donia M, Harbst K, Van Buuren M, Kvistborg P, Lindberg MF, Andersen R, Idorn M, Munir S, Ellebaek E, Mueller A, Fagone P, Nicoletti F, Libra M, Lauss M, Hadrup SR, ... ... Schumacher TN, et al. Acquired immune resistance follows complete tumor regression without loss of target antigens or IFN-γ signaling. Cancer Research. PMID 28655789 DOI: 10.1158/0008-5472.Can-16-3172 |
0.362 |
|
| 2017 |
Philips D, van den Braber M, Schumacher TN, Kvistborg P. pMHC Multiplexing Strategy to Detect High Numbers of T Cell Responses in Parallel. Methods in Molecular Biology (Clifton, N.J.). 1514: 93-101. PMID 27787794 DOI: 10.1007/978-1-4939-6548-9_7 |
0.452 |
|
| 2017 |
Regev A, Teichmann SA, Lander ES, Amit I, Benoist C, Birney E, Bodenmiller B, Campbell P, Carninci P, Clatworthy M, Clevers H, Deplancke B, Dunham I, Eberwine J, Eils R, ... ... Schumacher TN, et al. Author response: The Human Cell Atlas Elife. DOI: 10.7554/Elife.27041.011 |
0.459 |
|
| 2017 |
Rozeman EA, Blank CU, Akkooi ACJV, Kvistborg P, Fanchi L, Thienen JVV, Stegenga B, Lamon B, Haanen JBAG, Schumacher T. Neoadjuvant ipilimumab + nivolumab (IPI+NIVO) in palpable stage III melanoma: Updated data from the OpACIN trial and first immunological analyses. Journal of Clinical Oncology. 35: 9586-9586. DOI: 10.1200/Jco.2017.35.15_Suppl.9586 |
0.363 |
|
| 2017 |
Schumacher T. Abstract IA24: T cell recognition and tumor resistance in human cancer Cancer Immunology Research. 5. DOI: 10.1158/2326-6074.Tumimm16-Ia24 |
0.49 |
|
| 2016 |
Manzo T, Sturmheit T, Basso V, Petrozziello E, Hess Michelini R, Riba M, Freschi M, Elia AR, Grioni M, Curnis F, Protti MP, Schumacher TN, Debets R, Swartz MA, Corti A, et al. T cells redirected to a minor histocompatibility antigen instruct intratumoral TNF-α expression and empower adoptive cell therapy for solid tumors. Cancer Research. PMID 27872095 DOI: 10.1158/0008-5472.CAN-16-0725 |
0.342 |
|
| 2016 |
Linnemann C, van Buuren MM, Bies L, Verdegaal EM, Schotte R, Calis JJ, Behjati S, Velds A, Hilkmann H, El Atmioui D, Visser M, Stratton MR, Haanen JB, Spits H, van der Burg SH, ... Schumacher TN, et al. Corrigendum: High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4 T cells in human melanoma. Nature Medicine. 22: 1192. PMID 27711057 DOI: 10.1038/Nm1016-1192D |
0.431 |
|
| 2016 |
Textor A, Schmidt K, Kloetzel PM, Weißbrich B, Perez C, Charo J, Anders K, Sidney J, Sette A, Schumacher TN, Keller C, Busch DH, Seifert U, Blankenstein T. Preventing tumor escape by targeting a post-proteasomal trimming independent epitope. The Journal of Experimental Medicine. PMID 27697836 DOI: 10.1084/Jem.20160636 |
0.506 |
|
| 2016 |
Schumacher TN, Hacohen N. Neoantigens encoded in the cancer genome. Current Opinion in Immunology. 41: 98-103. PMID 27518850 DOI: 10.1016/J.Coi.2016.07.005 |
0.406 |
|
| 2016 |
Verdegaal EM, de Miranda NF, Visser M, Harryvan T, van Buuren MM, Andersen RS, Hadrup SR, van der Minne CE, Schotte R, Spits H, Haanen JB, Kapiteijn EH, Schumacher TN, van der Burg SH. Neoantigen landscape dynamics during human melanoma-T cell interactions. Nature. PMID 27350335 DOI: 10.1038/nature18945 |
0.466 |
|
| 2016 |
Strønen E, Toebes M, Kelderman S, van Buuren MM, Yang W, van Rooij N, Donia M, Böschen ML, Lund-Johansen F, Olweus J, Schumacher TN. Targeting of cancer neoantigens with donor-derived T cell receptor repertoires. Science (New York, N.Y.). PMID 27198675 DOI: 10.1126/science.aaf2288 |
0.462 |
|
| 2016 |
Blank CU, Haanen JB, Ribas A, Schumacher TN. CANCER IMMUNOLOGY. The "cancer immunogram". Science (New York, N.Y.). 352: 658-60. PMID 27151852 DOI: 10.1126/Science.Aaf2834 |
0.324 |
|
| 2016 |
Buchholz VR, Schumacher TN, Busch DH. T Cell Fate at the Single-Cell Level. Annual Review of Immunology. 34: 65-92. PMID 26666651 DOI: 10.1146/Annurev-Immunol-032414-112014 |
0.529 |
|
| 2016 |
Verdegaal EME, Miranda Nd, Visser M, Harryvan T, Buuren Mv, Andersen R, Hadrup S, Minne Cvd, Schotte R, Spits H, Haanen J, Kapiteijn E, Schumacher T, Burg SHVD. Abstract PR11: Neo-antigen landscape dynamics during human melanoma-T cell interactions Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-Pr11 |
0.561 |
|
| 2016 |
Schumacher T. Abstract IA04: T cell recognition and tumor resistance in human cancer Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-Ia04 |
0.493 |
|
| 2016 |
Fanchi LF, Bies L, Song J, Linnemann C, Schumacher T. Abstract B044: Patient-specific immunotherapy through TCR gene transfer Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-B044 |
0.456 |
|
| 2015 |
Alanio C, Nicoli F, Sultanik P, Flecken T, Perot B, Duffy D, Bianchi E, Lim A, Clave E, van Buuren MM, Schnuriger A, Johnsson K, Boussier J, Garbarg-Chenon A, Bousquet L, ... ... Schumacher TN, et al. Bystander hyperactivation of preimmune CD8(+) T cells in chronic HCV patients. Elife. 4. PMID 26568315 DOI: 10.7554/eLife.07916 |
0.418 |
|
| 2015 |
Ariotti S, Beltman JB, Borsje R, Hoekstra ME, Halford WP, Haanen JB, de Boer RJ, Schumacher TN. Subtle CXCR3-Dependent Chemotaxis of CTLs within Infected Tissue Allows Efficient Target Localization. Journal of Immunology (Baltimore, Md. : 1950). 195: 5285-95. PMID 26525288 DOI: 10.4049/Jimmunol.1500853 |
0.451 |
|
| 2015 |
Berkers CR, de Jong A, Schuurman KG, Linnemann C, Meiring HD, Janssen L, Neefjes JJ, Schumacher TN, Rodenko B, Ovaa H. Definition of Proteasomal Peptide Splicing Rules for High-Efficiency Spliced Peptide Presentation by MHC Class I Molecules. Journal of Immunology (Baltimore, Md. : 1950). PMID 26401003 DOI: 10.4049/Jimmunol.1402455 |
0.56 |
|
| 2015 |
Berkers CR, de Jong A, Schuurman KG, Linnemann C, Geenevasen JA, Schumacher TN, Rodenko B, Ovaa H. Peptide Splicing in the Proteasome Creates a Novel Type of Antigen with an Isopeptide Linkage. Journal of Immunology (Baltimore, Md. : 1950). 195: 4075-84. PMID 26401000 DOI: 10.4049/Jimmunol.1402454 |
0.458 |
|
| 2015 |
Hawkins R, Gilham D, Sleijfer S, Lamers C, Debets R, Kiessling R, Thistlethwaite F, Lorigan P, Taylor N, Guest R, Chao D, Assenmacher M, Kaiser A, Schumacher T, Haanen J, et al. Adoptive Engineered T-Cell Trials to Achieve Cancer Killing (ATTACK) Human Gene Therapy. Clinical Development. 26: 79-81. PMID 26086752 DOI: 10.1089/Humc.2015.2521 |
0.397 |
|
| 2015 |
van den Berg JH, Gomez-Eerland R, van de Wiel B, Hulshoff L, van den Broek D, Bins A, Tan HL, Harper JV, Hassan NJ, Jakobsen BK, Jorritsma A, Blank CU, Schumacher TN, Haanen JB. Case Report of a Fatal Serious Adverse Event Upon Administration of T Cells Transduced With a MART-1-specific T-cell Receptor. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 25896248 DOI: 10.1038/Mt.2015.60 |
0.476 |
|
| 2015 |
Schumacher TN, Schreiber RD. Neoantigens in cancer immunotherapy. Science (New York, N.Y.). 348: 69-74. PMID 25838375 DOI: 10.1126/Science.Aaa4971 |
0.363 |
|
| 2015 |
June CH, Riddell SR, Schumacher TN. Adoptive cellular therapy: a race to the finish line. Science Translational Medicine. 7: 280ps7. PMID 25810311 DOI: 10.1126/Scitranslmed.Aaa3643 |
0.376 |
|
| 2015 |
Linnemann C, van Buuren MM, Bies L, Verdegaal EM, Schotte R, Calis JJ, Behjati S, Velds A, Hilkmann H, Atmioui DE, Visser M, Stratton MR, Haanen JB, Spits H, van der Burg SH, ... Schumacher TN, et al. High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma. Nature Medicine. 21: 81-5. PMID 25531942 DOI: 10.1038/Nm.3773 |
0.535 |
|
| 2015 |
Becattini S, Latorre D, Mele F, Foglierini M, De Gregorio C, Cassotta A, Fernandez B, Kelderman S, Schumacher TN, Corti D, Lanzavecchia A, Sallusto F. T cell immunity. Functional heterogeneity of human memory CD4⁺ T cell clones primed by pathogens or vaccines. Science (New York, N.Y.). 347: 400-6. PMID 25477212 DOI: 10.1126/science.1260668 |
0.435 |
|
| 2015 |
Kelderman S, Bies L, Buuren MMV, Rooij NV, Haanen J, Kvistborg P, Schumacher T. Abstract 4704: Neo-antigen enriched TIL therapy mediates superior tumor eradication in a patient-derived xenograft model of human melanoma Cancer Research. 75: 4704-4704. DOI: 10.1158/1538-7445.Am2015-4704 |
0.491 |
|
| 2015 |
Haanen JBAG, Berg JVd, Zon MV, Bakker N, Geukes M, Thienen HV, Blank C, Kvistborg P, Schumacher T. Abstract PL01-03: TIL therapy in the era of immune checkpoint blockade Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-Pl01-03 |
0.512 |
|
| 2015 |
Perié L, Duffy KR, Boer RJd, Schumacher T. Common myeloid progenitors are made up of distinct subpopulations that either yield erythrocytes or myeloid cells Experimental Hematology. 43. DOI: 10.1016/J.Exphem.2015.06.227 |
0.347 |
|
| 2014 |
Gubin MM, Zhang X, Schuster H, Caron E, Ward JP, Noguchi T, Ivanova Y, Hundal J, Arthur CD, Krebber WJ, Mulder GE, Toebes M, Vesely MD, Lam SS, Korman AJ, ... ... Schumacher TN, et al. Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens. Nature. 515: 577-81. PMID 25428507 DOI: 10.1038/Nature13988 |
0.344 |
|
| 2014 |
Hoppes R, Oostvogels R, Luimstra JJ, Wals K, Toebes M, Bies L, Ekkebus R, Rijal P, Celie PH, Huang JH, Emmelot ME, Spaapen RM, Lokhorst H, Schumacher TN, Mutis T, et al. Altered peptide ligands revisited: vaccine design through chemically modified HLA-A2-restricted T cell epitopes. Journal of Immunology (Baltimore, Md. : 1950). 193: 4803-13. PMID 25311806 DOI: 10.4049/Jimmunol.1400800 |
0.521 |
|
| 2014 |
Ariotti S, Hogenbirk MA, Dijkgraaf FE, Visser LL, Hoekstra ME, Song JY, Jacobs H, Haanen JB, Schumacher TN. T cell memory. Skin-resident memory CD8⁺ T cells trigger a state of tissue-wide pathogen alert. Science (New York, N.Y.). 346: 101-5. PMID 25278612 DOI: 10.1126/science.1254803 |
0.406 |
|
| 2014 |
Kvistborg P, Philips D, Kelderman S, Hageman L, Ottensmeier C, Joseph-Pietras D, Welters MJ, van der Burg S, Kapiteijn E, Michielin O, Romano E, Linnemann C, Speiser D, Blank C, Haanen JB, ... Schumacher TN, et al. Anti-CTLA-4 therapy broadens the melanoma-reactive CD8+ T cell response. Science Translational Medicine. 6: 254ra128. PMID 25232180 DOI: 10.1126/scitranslmed.3008918 |
0.464 |
|
| 2014 |
Gomez-Eerland R, Nuijen B, Heemskerk B, van Rooij N, van den Berg JH, Beijnen JH, Uckert W, Kvistborg P, Schumacher TN, Haanen JB, Jorritsma A. Manufacture of gene-modified human T-cells with a memory stem/central memory phenotype. Human Gene Therapy Methods. 25: 277-87. PMID 25143008 DOI: 10.1089/Hgtb.2014.004 |
0.384 |
|
| 2014 |
Kelderman S, Schumacher TN, Haanen JB. Acquired and intrinsic resistance in cancer immunotherapy. Molecular Oncology. 8: 1132-9. PMID 25106088 DOI: 10.1016/J.Molonc.2014.07.011 |
0.34 |
|
| 2014 |
van Buuren MM, Calis JJ, Schumacher TN. High sensitivity of cancer exome-based CD8 T cell neo-antigen identification. Oncoimmunology. 3: e28836. PMID 25083320 DOI: 10.4161/onci.28836 |
0.361 |
|
| 2014 |
Westerhuis G, de Witte M, Schumacher TN, Toes RE, Fibbe WE. Barriers to chimerism after major histocompatibility complex-mismatched stem cell transplantation: a potential role for heterologous immunity. Experimental Hematology. 42: 753-60. PMID 24732702 DOI: 10.1016/j.exphem.2014.04.001 |
0.32 |
|
| 2014 |
Rohr JC, Gerlach C, Kok L, Schumacher TN. Single cell behavior in T cell differentiation. Trends in Immunology. 35: 170-7. PMID 24657362 DOI: 10.1016/J.It.2014.02.006 |
0.493 |
|
| 2014 |
Kelderman S, Heemskerk B, van Tinteren H, van den Brom RR, Hospers GA, van den Eertwegh AJ, Kapiteijn EW, de Groot JW, Soetekouw P, Jansen RL, Fiets E, Furness AJ, Renn A, Krzystanek M, Szallasi Z, ... ... Schumacher TN, et al. Lactate dehydrogenase as a selection criterion for ipilimumab treatment in metastatic melanoma. Cancer Immunology, Immunotherapy : Cii. 63: 449-58. PMID 24609989 DOI: 10.1007/S00262-014-1528-9 |
0.338 |
|
| 2014 |
Kumari S, Wälchli S, Fallang LE, Yang W, Lund-Johansen F, Schumacher TN, Olweus J. Alloreactive cytotoxic T cells provide means to decipher the immunopeptidome and reveal a plethora of tumor-associated self-epitopes. Proceedings of the National Academy of Sciences of the United States of America. 111: 403-8. PMID 24344295 DOI: 10.1073/pnas.1306549111 |
0.436 |
|
| 2014 |
van Buuren MM, Dijkgraaf FE, Linnemann C, Toebes M, Chang CX, Mok JY, Nguyen M, van Esch WJ, Kvistborg P, Grotenbreg GM, Schumacher TN. HLA micropolymorphisms strongly affect peptide-MHC multimer-based monitoring of antigen-specific CD8+ T cell responses. Journal of Immunology (Baltimore, Md. : 1950). 192: 641-8. PMID 24342804 DOI: 10.4049/Jimmunol.1301770 |
0.514 |
|
| 2014 |
Kvistborg P, Philips D, Kelderman S, Hageman L, Ottensmeier C, Joseph-Pietras D, Welters MJP, Van Der Burg S, Kapiteijn E, Michielin O, Romano E, Linnemann C, Speiser D, Blank C, Haanen JB, ... Schumacher TN, et al. Anti-CTLA-4 therapy broadens the melanoma-reactive CD8+ T cell response Science Translational Medicine. 6. DOI: 10.1126/scitranslmed.3008918 |
0.462 |
|
| 2013 |
Linnemann C, Heemskerk B, Kvistborg P, Kluin RJ, Bolotin DA, Chen X, Bresser K, Nieuwland M, Schotte R, Michels S, Gomez-Eerland R, Jahn L, Hombrink P, Legrand N, Shu CJ, ... ... Schumacher TN, et al. High-throughput identification of antigen-specific TCRs by TCR gene capture. Nature Medicine. 19: 1534-41. PMID 24121928 DOI: 10.1038/Nm.3359 |
0.493 |
|
| 2013 |
van Rooij N, van Buuren MM, Philips D, Velds A, Toebes M, Heemskerk B, van Dijk LJ, Behjati S, Hilkmann H, El Atmioui D, Nieuwland M, Stratton MR, Kerkhoven RM, Kesmir C, Haanen JB, ... ... Schumacher TN, et al. Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 31: e439-42. PMID 24043743 DOI: 10.1200/JCO.2012.47.7521 |
0.384 |
|
| 2013 |
Hombrink P, Raz Y, Kester MG, de Boer R, Weißbrich B, von dem Borne PA, Busch DH, Schumacher TN, Falkenburg JH, Heemskerk MH. Mixed functional characteristics correlating with TCR-ligand koff -rate of MHC-tetramer reactive T cells within the naive T-cell repertoire. European Journal of Immunology. 43: 3038-50. PMID 23893393 DOI: 10.1002/Eji.201343397 |
0.56 |
|
| 2013 |
Kvistborg P, van Buuren MM, Schumacher TN. Human cancer regression antigens. Current Opinion in Immunology. 25: 284-90. PMID 23566921 DOI: 10.1016/j.coi.2013.03.005 |
0.365 |
|
| 2013 |
Gilchuk P, Spencer CT, Conant SB, Hill T, Gray JJ, Niu X, Zheng M, Erickson JJ, Boyd KL, McAfee KJ, Oseroff C, Hadrup SR, Bennink JR, Hildebrand W, Edwards KM, ... ... Schumacher TN, et al. Discovering naturally processed antigenic determinants that confer protective T cell immunity. The Journal of Clinical Investigation. 123: 1976-87. PMID 23543059 DOI: 10.1172/Jci67388 |
0.448 |
|
| 2013 |
Gerlach C, Rohr JC, Perié L, van Rooij N, van Heijst JW, Velds A, Urbanus J, Naik SH, Jacobs H, Beltman JB, de Boer RJ, Schumacher TN. Heterogeneous differentiation patterns of individual CD8+ T cells. Science (New York, N.Y.). 340: 635-9. PMID 23493421 DOI: 10.1126/Science.1235487 |
0.542 |
|
| 2013 |
Singh SK, Tummers B, Schumacher TN, Gomez R, Franken KL, Verdegaal EM, Laske K, Gouttefangeas C, Ottensmeier C, Welters MJ, Britten CM, van der Burg SH. The development of standard samples with a defined number of antigen-specific T cells to harmonize T cell assays: a proof-of-principle study. Cancer Immunology, Immunotherapy : Cii. 62: 489-501. PMID 22986454 DOI: 10.1007/s00262-012-1351-0 |
0.439 |
|
| 2013 |
Rooij Nv, Haanen JBAG, Buren Mv, Philips D, Toebes M, Heemskerk B, Dijk Lv, Behjati S, Stratton MR, Kerkhoven RM, Kesmir C, Kvistborg P, Schumacher T. Use of tumor exome analysis to reveal neo-antigen-specific T-cell reactivity in ipilimumab-responsive melanoma. Journal of Clinical Oncology. 31: 9085-9085. DOI: 10.1200/Jco.2013.31.15_Suppl.9085 |
0.538 |
|
| 2013 |
Haanen JBAG, Kvistborg P, Philips D, Kelderman S, Heemskerk B, Ottensmeier C, Speiser DE, Michielin OA, Romano E, Blank CU, Schumacher T. Dissection of anti-CTLA4-induced cytotoxic T-cell responses in melanoma. Journal of Clinical Oncology. 31: 9078-9078. DOI: 10.1200/Jco.2013.31.15_Suppl.9078 |
0.545 |
|
| 2013 |
Kelderman S, Heemskerk B, Toebes M, Buuren Mv, Rooij Nv, Bies L, Fanchi L, Germeroth L, Kvistborg P, Schumacher T. Antigen-specific TIL therapy for melanoma: a flexible platform for personalized cancer immunotherapy Journal For Immunotherapy of Cancer. 1: 19. DOI: 10.1186/2051-1426-1-S1-P19 |
0.586 |
|
| 2012 |
Ariotti S, Beltman JB, Chodaczek G, Hoekstra ME, van Beek AE, Gomez-Eerland R, Ritsma L, van Rheenen J, Marée AF, Zal T, de Boer RJ, Haanen JB, Schumacher TN. Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen. Proceedings of the National Academy of Sciences of the United States of America. 109: 19739-44. PMID 23150545 DOI: 10.1073/pnas.1208927109 |
0.382 |
|
| 2012 |
Hooijkaas A, Gadiot J, Morrow M, Stewart R, Schumacher T, Blank CU. Selective BRAF inhibition decreases tumor-resident lymphocyte frequencies in a mouse model of human melanoma. Oncoimmunology. 1: 609-617. PMID 22934253 DOI: 10.4161/Onci.20226 |
0.378 |
|
| 2012 |
Kvistborg P, Shu CJ, Heemskerk B, Fankhauser M, Thrue CA, Toebes M, van Rooij N, Linnemann C, van Buuren MM, Urbanus JH, Beltman JB, Thor Straten P, Li YF, Robbins PF, Besser MJ, ... ... Schumacher TN, et al. TIL therapy broadens the tumor-reactive CD8(+) T cell compartment in melanoma patients. Oncoimmunology. 1: 409-418. PMID 22754759 DOI: 10.4161/Onci.18851 |
0.539 |
|
| 2012 |
Andersen RS, Kvistborg P, Frøsig TM, Pedersen NW, Lyngaa R, Bakker AH, Shu CJ, Straten Pt, Schumacher TN, Hadrup SR. Parallel detection of antigen-specific T cell responses by combinatorial encoding of MHC multimers. Nature Protocols. 7: 891-902. PMID 22498709 DOI: 10.1038/nprot.2012.037 |
0.497 |
|
| 2012 |
Ariotti S, Haanen JB, Schumacher TN. Behavior and function of tissue-resident memory T cells. Advances in Immunology. 114: 203-16. PMID 22449783 DOI: 10.1016/B978-0-12-396548-6.00008-1 |
0.327 |
|
| 2012 |
Andersen RS, Thrue CA, Junker N, Lyngaa R, Donia M, Ellebæk E, Svane IM, Schumacher TN, Thor Straten P, Hadrup SR. Dissection of T-cell antigen specificity in human melanoma. Cancer Research. 72: 1642-50. PMID 22311675 DOI: 10.1158/0008-5472.CAN-11-2614 |
0.452 |
|
| 2012 |
Wolkers MC, Gerlach C, Arens R, Janssen EM, Fitzgerald P, Schumacher TN, Medema JP, Green DR, Schoenberger SP. Nab2 regulates secondary CD8+ T-cell responses through control of TRAIL expression. Blood. 119: 798-804. PMID 22128144 DOI: 10.1182/Blood-2011-08-373910 |
0.407 |
|
| 2012 |
Amore A, Wals K, Koekoek E, Hoppes R, Toebes M, Schumacher T, Rodenko B, Ovaa H. A novel chemocleavable linker and its application in MHC class I peptide exchange Molecular Immunology. 51: 6-7. DOI: 10.1016/J.Molimm.2012.02.011 |
0.37 |
|
| 2011 |
Hombrink P, Hadrup SR, Bakker A, Kester MG, Falkenburg JH, von dem Borne PA, Schumacher TN, Heemskerk MH. High-throughput identification of potential minor histocompatibility antigens by MHC tetramer-based screening: feasibility and limitations. Plos One. 6: e22523. PMID 21850230 DOI: 10.1371/Journal.Pone.0022523 |
0.549 |
|
| 2011 |
Unger WW, Velthuis J, Abreu JR, Laban S, Quinten E, Kester MG, Reker-Hadrup S, Bakker AH, Duinkerken G, Mulder A, Franken KL, Hilbrands R, Keymeulen B, Peakman M, Ossendorp F, ... ... Schumacher TN, et al. Discovery of low-affinity preproinsulin epitopes and detection of autoreactive CD8 T-cells using combinatorial MHC multimers. Journal of Autoimmunity. 37: 151-9. PMID 21636247 DOI: 10.1016/j.jaut.2011.05.012 |
0.372 |
|
| 2011 |
Jorritsma A, Schotte R, Coccoris M, de Witte MA, Schumacher TN. Prospects and limitations of T cell receptor gene therapy. Current Gene Therapy. 11: 276-87. PMID 21453279 DOI: 10.2174/156652311796150390 |
0.362 |
|
| 2011 |
Schulte I, Hitziger T, Giugliano S, Timm J, Gold H, Heinemann FM, Khudyakov Y, Strasser M, König C, Castermans E, Mok JY, van Esch WJ, Bertoletti A, Schumacher TN, Roggendorf M. Characterization of CD8+ T-cell response in acute and resolved hepatitis A virus infection. Journal of Hepatology. 54: 201-8. PMID 21056495 DOI: 10.1016/j.jhep.2010.07.010 |
0.342 |
|
| 2010 |
Abrahamsen IW, Stronen E, Wälchli S, Johansen JN, Kjellevoll S, Kumari S, Komada M, Gaudernack G, Tjonnfjord G, Toebes M, Schumacher TN, Lund-Johansen F, Olweus J. Targeting B cell leukemia with highly specific allogeneic T cells with a public recognition motif. Leukemia. 24: 1901-9. PMID 20844564 DOI: 10.1038/leu.2010.186 |
0.508 |
|
| 2010 |
Wensveen FM, van Gisbergen KP, Derks IA, Gerlach C, Schumacher TN, van Lier RA, Eldering E. Apoptosis threshold set by Noxa and Mcl-1 after T cell activation regulates competitive selection of high-affinity clones. Immunity. 32: 754-65. PMID 20620942 DOI: 10.1016/j.immuni.2010.06.005 |
0.473 |
|
| 2010 |
Gerlach C, van Heijst JW, Swart E, Sie D, Armstrong N, Kerkhoven RM, Zehn D, Bevan MJ, Schepers K, Schumacher TN. One naive T cell, multiple fates in CD8+ T cell differentiation. The Journal of Experimental Medicine. 207: 1235-46. PMID 20479114 DOI: 10.1084/Jem.20091175 |
0.766 |
|
| 2010 |
Hawkins RE, Gilham DE, Debets R, Eshhar Z, Taylor N, Abken H, Schumacher TN, ATTACK Consortium. Development of adoptive cell therapy for cancer: a clinical perspective. Human Gene Therapy. 21: 665-72. PMID 20408760 DOI: 10.1089/Hum.2010.086 |
0.358 |
|
| 2010 |
Bendle GM, Linnemann C, Hooijkaas AI, Bies L, de Witte MA, Jorritsma A, Kaiser AD, Pouw N, Debets R, Kieback E, Uckert W, Song JY, Haanen JB, Schumacher TN. Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy. Nature Medicine. 16: 565-70, 1p following. PMID 20400962 DOI: 10.1038/Nm.2128 |
0.46 |
|
| 2010 |
Velthuis JH, Unger WW, Abreu JR, Duinkerken G, Franken K, Peakman M, Bakker AH, Reker-Hadrup S, Keymeulen B, Drijfhout JW, Schumacher TN, Roep BO. Simultaneous detection of circulating autoreactive CD8+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers. Diabetes. 59: 1721-30. PMID 20357361 DOI: 10.2337/db09-1486 |
0.443 |
|
| 2010 |
Borkner L, Kaiser A, van de Kasteele W, Andreesen R, Mackensen A, Haanen JB, Schumacher TN, Blank C. RNA interference targeting programmed death receptor-1 improves immune functions of tumor-specific T cells. Cancer Immunology, Immunotherapy : Cii. 59: 1173-83. PMID 20349059 DOI: 10.1007/s00262-010-0842-0 |
0.319 |
|
| 2010 |
Hadrup SR, Schumacher TN. MHC-based detection of antigen-specific CD8+ T cell responses. Cancer Immunology, Immunotherapy : Cii. 59: 1425-33. PMID 20177676 DOI: 10.1007/s00262-010-0824-2 |
0.472 |
|
| 2010 |
Roggendorf M, Schulte I, Hitziger T, Giugliano S, Timm J, Gold H, Heinemann F, Khudyakov Y, Koenig C, Castermans E, Mok J, van Esch W, Bertoletti A, Schumacher T. 85 ACUTE HEPATITIS A IS ASSOCIATED WITH A MULTISPECIFIC CD8+ T CELL RESPONSE IN HLA-A2 POSITIVE PATIENTS Journal of Hepatology. 52: S39. DOI: 10.1016/S0168-8278(10)60087-6 |
0.317 |
|
| 2009 |
Wright GP, Notley CA, Xue SA, Bendle GM, Holler A, Schumacher TN, Ehrenstein MR, Stauss HJ. Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis. Proceedings of the National Academy of Sciences of the United States of America. 106: 19078-83. PMID 19884493 DOI: 10.1073/pnas.0907396106 |
0.465 |
|
| 2009 |
Sørensen RB, Berge-Hansen L, Junker N, Hansen CA, Hadrup SR, Schumacher TN, Svane IM, Becker JC, thor Straten P, Andersen MH. The immune system strikes back: cellular immune responses against indoleamine 2,3-dioxygenase. Plos One. 4: e6910. PMID 19738905 DOI: 10.1371/Journal.Pone.0006910 |
0.534 |
|
| 2009 |
van Heijst JW, Gerlach C, Swart E, Sie D, Nunes-Alves C, Kerkhoven RM, Arens R, Correia-Neves M, Schepers K, Schumacher TN. Recruitment of antigen-specific CD8+ T cells in response to infection is markedly efficient. Science (New York, N.Y.). 325: 1265-9. PMID 19729659 DOI: 10.1126/Science.1175455 |
0.779 |
|
| 2009 |
Kwong GA, Radu CG, Hwang K, Shu CJ, Ma C, Koya RC, Comin-Anduix B, Hadrup SR, Bailey RC, Witte ON, Schumacher TN, Ribas A, Heath JR. Modular nucleic acid assembled p/MHC microarrays for multiplexed sorting of antigen-specific T cells. Journal of the American Chemical Society. 131: 9695-703. PMID 19552409 DOI: 10.1021/Ja9006707 |
0.441 |
|
| 2009 |
Hadrup SR, Bakker AH, Shu CJ, Andersen RS, van Veluw J, Hombrink P, Castermans E, Thor Straten P, Blank C, Haanen JB, Heemskerk MH, Schumacher TN. Parallel detection of antigen-specific T-cell responses by multidimensional encoding of MHC multimers. Nature Methods. 6: 520-6. PMID 19543285 DOI: 10.1038/Nmeth.1345 |
0.418 |
|
| 2009 |
Hadrup SR, Toebes M, Rodenko B, Bakker AH, Egan DA, Ovaa H, Schumacher TN. High-throughput T-cell epitope discovery through MHC peptide exchange. Methods in Molecular Biology (Clifton, N.J.). 524: 383-405. PMID 19377960 DOI: 10.1007/978-1-59745-450-6_28 |
0.5 |
|
| 2009 |
Schumacher TN, Restifo NP. Adoptive T cell therapy of cancer Current Opinion in Immunology. 21: 187-189. PMID 19328668 DOI: 10.1016/J.Coi.2009.03.006 |
0.568 |
|
| 2009 |
van der Veken LT, Coccoris M, Swart E, Falkenburg JH, Schumacher TN, Heemskerk MH. Alpha beta T cell receptor transfer to gamma delta T cells generates functional effector cells without mixed TCR dimers in vivo. Journal of Immunology (Baltimore, Md. : 1950). 182: 164-70. PMID 19109147 DOI: 10.4049/jimmunol.182.1.164 |
0.447 |
|
| 2009 |
Abreu J, Velthuis J, Unger W, Franken K, Schumacher T, Roep B. OR.9. Detection of Islet-specific Autoreactive T Cells by a Novel Robust and High Throughput Screening Strategy in Stored Blood Samples of Type 1 Diabetic Patients Clinical Immunology. 131. DOI: 10.1016/J.Clim.2009.03.016 |
0.527 |
|
| 2008 |
Bos R, van Duikeren S, Morreau H, Franken K, Schumacher TN, Haanen JB, van der Burg SH, Melief CJ, Offringa R. Balancing between antitumor efficacy and autoimmune pathology in T-cell-mediated targeting of carcinoembryonic antigen. Cancer Research. 68: 8446-55. PMID 18922918 DOI: 10.1158/0008-5472.Can-08-1864 |
0.505 |
|
| 2008 |
Schepers K, Swart E, van Heijst JW, Gerlach C, Castrucci M, Sie D, Heimerikx M, Velds A, Kerkhoven RM, Arens R, Schumacher TN. Dissecting T cell lineage relationships by cellular barcoding. The Journal of Experimental Medicine. 205: 2309-18. PMID 18809713 DOI: 10.1084/Jem.20072462 |
0.767 |
|
| 2008 |
de Witte MA, Jorritsma A, Kaiser A, van den Boom MD, Dokter M, Bendle GM, Haanen JB, Schumacher TN. Requirements for effective antitumor responses of TCR transduced T cells. Journal of Immunology (Baltimore, Md. : 1950). 181: 5128-36. PMID 18802117 DOI: 10.4049/Jimmunol.181.7.5128 |
0.53 |
|
| 2008 |
de Witte MA, Bendle GM, van den Boom MD, Coccoris M, Schell TD, Tevethia SS, van Tinteren H, Mesman EM, Song JY, Schumacher TN. TCR gene therapy of spontaneous prostate carcinoma requires in vivo T cell activation. Journal of Immunology (Baltimore, Md. : 1950). 181: 2563-71. PMID 18684947 DOI: 10.4049/Jimmunol.181.4.2563 |
0.484 |
|
| 2008 |
Verstrepen BE, Bins AD, Rollier CS, Mooij P, Koopman G, Sheppard NC, Sattentau Q, Wagner R, Wolf H, Schumacher TN, Heeney JL, Haanen JB. Improved HIV-1 specific T-cell responses by short-interval DNA tattooing as compared to intramuscular immunization in non-human primates. Vaccine. 26: 3346-51. PMID 18467010 DOI: 10.1016/J.Vaccine.2008.03.091 |
0.392 |
|
| 2008 |
Coccoris M, Swart E, de Witte MA, van Heijst JW, Haanen JB, Schepers K, Schumacher TN. Long-term functionality of TCR-transduced T cells in vivo. Journal of Immunology (Baltimore, Md. : 1950). 180: 6536-43. PMID 18453572 DOI: 10.4049/Jimmunol.180.10.6536 |
0.765 |
|
| 2008 |
Bakker AH, Hoppes R, Linnemann C, Toebes M, Rodenko B, Berkers CR, Hadrup SR, van Esch WJ, Heemskerk MH, Ovaa H, Schumacher TN. Conditional MHC class I ligands and peptide exchange technology for the human MHC gene products HLA-A1, -A3, -A11, and -B7. Proceedings of the National Academy of Sciences of the United States of America. 105: 3825-30. PMID 18308940 DOI: 10.1073/Pnas.0709717105 |
0.44 |
|
| 2008 |
Abad JD, Wrzensinski C, Overwijk W, De Witte MA, Jorritsma A, Hsu C, Gattinoni L, Cohen CJ, Paulos CM, Palmer DC, Haanen JB, Schumacher TN, Rosenberg SA, Restifo NP, Morgan RA. T-cell receptor gene therapy of established tumors in a murine melanoma model. Journal of Immunotherapy (Hagerstown, Md. : 1997). 31: 1-6. PMID 18157006 DOI: 10.1097/Cji.0B013E31815C193F |
0.465 |
|
| 2008 |
Hombrink P, Hadrup SR, Bakker A, Falkenburg JF, Von Dem Borne PA, Schumacher TN, Heemskerk MH. SNP-Based Genome-Wide Identification of Hematopoiesis-Restricted Minor Histocompatibility Antigens Blood. 112: 814-814. DOI: 10.1182/blood.v112.11.814.814 |
0.418 |
|
| 2007 |
van Lent AU, Nagasawa M, van Loenen MM, Schotte R, Schumacher TN, Heemskerk MH, Spits H, Legrand N. Functional human antigen-specific T cells produced in vitro using retroviral T cell receptor transfer into hematopoietic progenitors. Journal of Immunology (Baltimore, Md. : 1950). 179: 4959-68. PMID 17911580 DOI: 10.4049/Jimmunol.179.8.4959 |
0.498 |
|
| 2006 |
Kessels HW, Schepers K, van den Boom MD, Topham DJ, Schumacher TN. Generation of T cell help through a MHC class I-restricted TCR. Journal of Immunology (Baltimore, Md. : 1950). 177: 976-82. PMID 16818753 DOI: 10.4049/Jimmunol.177.2.976 |
0.785 |
|
| 2006 |
Lukens MV, Claassen EA, de Graaff PM, van Dijk ME, Hoogerhout P, Toebes M, Schumacher TN, van der Most RG, Kimpen JL, van Bleek GM. Characterization of the CD8+ T cell responses directed against respiratory syncytial virus during primary and secondary infection in C57BL/6 mice. Virology. 352: 157-68. PMID 16730775 DOI: 10.1016/J.VIROL.2006.04.023 |
0.36 |
|
| 2006 |
MacLeod M, Kwakkenbos MJ, Crawford A, Brown S, Stockinger B, Schepers K, Schumacher T, Gray D. CD4 memory T cells survive and proliferate but fail to differentiate in the absence of CD40. The Journal of Experimental Medicine. 203: 897-906. PMID 16549596 DOI: 10.1084/Jem.20050711 |
0.755 |
|
| 2006 |
Crawford A, MacLeod M, Schumacher T, Corlett L, Gray D. Primary T cell expansion and differentiation in vivo requires antigen presentation by B cells. Journal of Immunology. 176: 3498-3506. PMID 16517718 DOI: 10.4049/Jimmunol.176.6.3498 |
0.533 |
|
| 2005 |
Schepers K, Arens R, Schumacher TN. Dissection of cytotoxic and helper T cell responses. Cellular and Molecular Life Sciences : Cmls. 62: 2695-710. PMID 16231088 DOI: 10.1007/S00018-005-5266-1 |
0.773 |
|
| 2005 |
Bakker AH, Schumacher TN. MHC multimer technology: current status and future prospects. Current Opinion in Immunology. 17: 428-33. PMID 15967654 DOI: 10.1016/J.Coi.2005.06.008 |
0.509 |
|
| 2005 |
Bins AD, Jorritsma A, Wolkers MC, Hung CF, Wu TC, Schumacher TN, Haanen JB. A rapid and potent DNA vaccination strategy defined by in vivo monitoring of antigen expression. Nature Medicine. 11: 899-904. PMID 15965482 DOI: 10.1038/Nm1264 |
0.302 |
|
| 2005 |
Ressing ME, van Leeuwen D, Verreck FA, Keating S, Gomez R, Franken KL, Ottenhoff TH, Spriggs M, Schumacher TN, Hutt-Fletcher LM, Rowe M, Wiertz EJ. Epstein-Barr virus gp42 is posttranslationally modified to produce soluble gp42 that mediates HLA class II immune evasion. Journal of Virology. 79: 841-52. PMID 15613312 DOI: 10.1128/Jvi.79.2.841-852.2005 |
0.326 |
|
| 2004 |
Oijen Mv, Bins A, Elias S, Sein J, Weder P, Gast Gd, Mallo H, Gallee M, Tinteren Hv, Schumacher T, Haanen J. On the Role of Melanoma-Specific CD8+ T-Cell Immunity in Disease Progression of Advanced-Stage Melanoma Patients Clinical Cancer Research. 10: 4754-4760. PMID 15269149 DOI: 10.1158/1078-0432.Ccr-04-0260 |
0.544 |
|
| 2004 |
Wolkers MC, Brouwenstijn N, Bakker AH, Toebes M, Schumacher TN. Antigen bias in T cell cross-priming. Science (New York, N.Y.). 304: 1314-7. PMID 15166378 DOI: 10.1126/Science.1096268 |
0.578 |
|
| 2004 |
Kessels HW, de Visser KE, Tirion FH, Coccoris M, Kruisbeek AM, Schumacher TN. The impact of self-tolerance on the polyclonal CD8+ T cell repertoire. Journal of Immunology (Baltimore, Md. : 1950). 172: 2324-31. PMID 14764701 DOI: 10.4049/Jimmunol.172.4.2324 |
0.52 |
|
| 2003 |
Schepers K, Schumacher TN. Tumors hijack fetal enzyme, escape killer T cells. Nature Medicine. 9: 1253-4. PMID 14520367 DOI: 10.1038/Nm1003-1253 |
0.737 |
|
| 2003 |
Ressing ME, Van Leeuwen D, Verreck FAW, Gomez R, Heemskerk B, Toebes M, Mullen MM, Jardetzky TS, Longnecker R, Schilham MW, Ottenhoff THM, Neefjes J, Schumacher TN, Hutt-Fletcher LM, Wiertz EJHJ. Interference with T cell receptor-HLA-DR interactions by Epstein-Barr virus gp42 results in reduced T helper cell recognition Proceedings of the National Academy of Sciences of the United States of America. 100: 11583-11588. PMID 14504389 DOI: 10.1073/Pnas.2034960100 |
0.583 |
|
| 2003 |
Johnson BJ, Costelloe EO, Fitzpatrick DR, Haanen JB, Schumacher TN, Brown LE, Kelso A. Single-cell perforin and granzyme expression reveals the anatomical localization of effector CD8+ T cells in influenza virus-infected mice. Proceedings of the National Academy of Sciences of the United States of America. 100: 2657-62. PMID 12601154 DOI: 10.1073/Pnas.0538056100 |
0.433 |
|
| 2003 |
De Visser KE, Schumacher TN, Kruisbeek AM. CD8+ T cell tolerance and cancer immunotherapy. Journal of Immunotherapy (Hagerstown, Md. : 1997). 26: 1-11. PMID 12514424 DOI: 10.1097/00002371-200301000-00001 |
0.485 |
|
| 2002 |
Olbrich AR, Schimmer S, Heeg K, Schepers K, Schumacher TN, Dittmer U. Effective postexposure treatment of retrovirus-induced disease with immunostimulatory DNA containing CpG motifs. Journal of Virology. 76: 11397-404. PMID 12388700 DOI: 10.1128/Jvi.76.22.11397-11404.2002 |
0.71 |
|
| 2002 |
Schepers K, Toebes M, Sotthewes G, Vyth-Dreese FA, Dellemijn TA, Melief CJ, Ossendorp F, Schumacher TN. Differential kinetics of antigen-specific CD4+ and CD8+ T cell responses in the regression of retrovirus-induced sarcomas. Journal of Immunology (Baltimore, Md. : 1950). 169: 3191-9. PMID 12218137 DOI: 10.4049/Jimmunol.169.6.3191 |
0.755 |
|
| 2002 |
Dickinson AM, Wang XN, Sviland L, Vyth-Dreese FA, Jackson GH, Schumacher TN, Haanen JB, Mutis T, Goulmy E. In situ dissection of the graft-versus-host activities of cytotoxic T cells specific for minor histocompatibility antigens. Nature Medicine. 8: 410-4. PMID 11927949 DOI: 10.1038/Nm0402-410 |
0.469 |
|
| 2002 |
Stromnes IM, Dittmer U, Schumacher TN, Schepers K, Messer RJ, Evans LH, Peterson KE, Race B, Hasenkrug KJ. Temporal effects of gamma interferon deficiency on the course of Friend retrovirus infection in mice. Journal of Virology. 76: 2225-32. PMID 11836400 DOI: 10.1128/Jvi.76.5.2225-2232.2002 |
0.657 |
|
| 2002 |
Cordaro TA, de Visser KE, Tirion FH, Schumacher TN, Kruisbeek AM. Can the low-avidity self-specific T cell repertoire be exploited for tumor rejection? Journal of Immunology (Baltimore, Md. : 1950). 168: 651-60. PMID 11777958 DOI: 10.4049/Jimmunol.168.2.651 |
0.488 |
|
| 2001 |
Kessels HW, de Visser KE, Kruisbeek AM, Schumacher TN. Circumventing T-cell tolerance to tumour antigens. Biologicals : Journal of the International Association of Biological Standardization. 29: 277-83. PMID 11851328 DOI: 10.1006/Biol.2001.0300 |
0.55 |
|
| 2001 |
Kessels HW, Wolkers MC, van den Boom MD, van der Valk MA, Schumacher TN. Immunotherapy through TCR gene transfer. Nature Immunology. 2: 957-61. PMID 11577349 DOI: 10.1038/ni1001-957 |
0.432 |
|
| 2001 |
de Visser KE, Cordaro TA, Kessels HW, Tirion FH, Schumacher TN, Kruisbeek AM. Low-avidity self-specific T cells display a pronounced expansion defect that can be overcome by altered peptide ligands. Journal of Immunology (Baltimore, Md. : 1950). 167: 3818-28. PMID 11564799 DOI: 10.4049/jimmunol.167.7.3818 |
0.418 |
|
| 2001 |
Sutmuller RP, van Duivenvoorde LM, van Elsas A, Schumacher TN, Wildenberg ME, Allison JP, Toes RE, Offringa R, Melief CJ. Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses. The Journal of Experimental Medicine. 194: 823-32. PMID 11560997 DOI: 10.1084/Jem.194.6.823 |
0.558 |
|
| 2001 |
Medema JP, Schuurhuis DH, Rea D, van Tongeren J, de Jong J, Bres SA, Laban S, Toes RE, Toebes M, Schumacher TN, Bladergroen BA, Ossendorp F, Kummer JA, Melief CJ, Offringa R. Expression of the serpin serine protease inhibitor 6 protects dendritic cells from cytotoxic T lymphocyte-induced apoptosis: differential modulation by T helper type 1 and type 2 cells. The Journal of Experimental Medicine. 194: 657-67. PMID 11535633 DOI: 10.1084/Jem.194.5.657 |
0.461 |
|
| 2000 |
Hendriks J, Gravestein LA, Tesselaar K, van Lier RA, Schumacher TN, Borst J. CD27 is required for generation and long-term maintenance of T cell immunity. Nature Immunology. 1: 433-40. PMID 11062504 DOI: 10.1038/80877 |
0.507 |
|
| 2000 |
Wallace ME, Bryden M, Cose SC, Coles RM, Schumacher TN, Brooks A, Carbone FR. Junctional biases in the naive TCR repertoire control the CTL response to an immunodominant determinant of HSV-1. Immunity. 12: 547-56. PMID 10843387 DOI: 10.1016/S1074-7613(00)80206-X |
0.4 |
|
| 2000 |
de Visser KE, Cordaro TA, Kioussis D, Haanen JB, Schumacher TN, Kruisbeek AM. Tracing and characterization of the low-avidity self-specific T cell repertoire. European Journal of Immunology. 30: 1458-68. PMID 10820394 DOI: 10.1002/(Sici)1521-4141(200005)30:5<1458::Aid-Immu1458>3.0.Co;2-2 |
0.539 |
|
| 1999 |
Smyth LA, Reynolds L, Tyrrell R, Williams O, Norton T, Schumacher T, Tybulewicz V, Ley SC, Kioussis D. Signaling in primary thymocytes after presentation of altered peptide ligands by antigen-presenting cells or MHC-peptide tetramers. Cold Spring Harbor Symposia On Quantitative Biology. 64: 275-81. PMID 11232297 DOI: 10.1101/Sqb.1999.64.275 |
0.42 |
|
| 1999 |
Diehl L, den Boer AT, Schoenberger SP, van der Voort EI, Schumacher TN, Melief CJ, Offringa R, Toes RE. CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy. Nature Medicine. 5: 774-9. PMID 10395322 DOI: 10.1038/10495 |
0.393 |
|
| 1996 |
Schumacher TN, Mayr LM, Minor DL, Milhollen MA, Burgess MW, Kim PS. Identification of D-peptide ligands through mirror-image phage display. Science (New York, N.Y.). 271: 1854-7. PMID 8596952 DOI: 10.1126/Science.271.5257.1854 |
0.489 |
|
| 1995 |
Schumacher TN, Ploegh HL. Are MHC-bound peptides a nuisance for positive selection? Immunity. 1: 721-3. PMID 7895161 DOI: 10.1016/S1074-7613(94)80013-8 |
0.499 |
|
| 1995 |
Schumacher TN, Kantesaria DV, Serreze DV, Roopenian DC, Ploegh HL. Transporters from H-2b, H-2d, H-2s, H-2k, and H-2g7 (NOD/Lt) haplotype translocate similar sets of peptides. Proceedings of the National Academy of Sciences of the United States of America. 91: 13004-8. PMID 7809164 DOI: 10.1073/Pnas.91.26.13004 |
0.485 |
|
| 1994 |
Schumacher TN, Kantesaria DV, Heemels MT, Ashton-Rickardt PG, Shepherd JC, Fruh K, Yang Y, Peterson PA, Tonegawa S, Ploegh HL. Peptide length and sequence specificity of the mouse TAP1/TAP2 translocator. The Journal of Experimental Medicine. 179: 533-40. PMID 8294864 DOI: 10.1084/Jem.179.2.533 |
0.524 |
|
| 1994 |
Heemels MT, Schumacher TN, Wonigeit K, Ploegh HL. Peptide translocation by variants of the transporter associated with antigen processing. Science (New York, N.Y.). 262: 2059-63. PMID 8266106 DOI: 10.1126/Science.8266106 |
0.53 |
|
| 1993 |
Ashton-Rickardt PG, Van Kaer L, Schumacher TN, Ploegh HL, Tonegawa S. Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus. Cell. 73: 1041-9. PMID 8500174 DOI: 10.1016/0092-8674(93)90281-T |
0.637 |
|
| 1993 |
Rohren EM, Pease LR, Ploegh HL, Schumacher TN. Polymorphisms in pockets of major histocompatibility complex class I molecules influence peptide preference. The Journal of Experimental Medicine. 177: 1713-21. PMID 8496687 DOI: 10.1084/Jem.177.6.1713 |
0.532 |
|
| 1993 |
Shepherd JC, Schumacher TN, Ashton-Rickardt PG, Imaeda S, Ploegh HL, Janeway CA, Tonegawa S. TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective. Cell. 74: 577-84. PMID 8348620 DOI: 10.1016/0092-8674(93)80058-M |
0.59 |
|
| 1993 |
Ashton-Rickardt PG, Van Kaer L, Schumacher TN, Ploegh HL, Tonegawa S. Repertoire-determining role of peptide in the positive selection of CD8+ T cells. Immunological Reviews. 135: 157-82. PMID 8282312 DOI: 10.1111/J.1600-065X.1993.Tb00648.X |
0.627 |
|
| 1992 |
Deres K, Schumacher TN, Wiesmüller KH, Stevanović S, Greiner G, Jung G, Ploegh HL. Preferred size of peptides that bind to H-2 Kb is sequence dependent. European Journal of Immunology. 22: 1603-8. PMID 1376267 DOI: 10.1002/Eji.1830220638 |
0.517 |
|
| 1992 |
Schumacher TN, Van Bleek GM, Heemels MT, Deres K, Li KW, Imarai M, Vernie LN, Nathenson SG, Ploegh HL. Synthetic peptide libraries in the determination of T cell epitopes and peptide binding specificity of class I molecules. European Journal of Immunology. 22: 1405-12. PMID 1376257 DOI: 10.1002/Eji.1830220612 |
0.573 |
|
| 1992 |
Guimezanes A, Schumacher TN, Ploegh HL, Schmitt-Verhulst AM. A viral peptide can mimic an endogenous peptide for allorecognition of a major histocompatibility complex class I product. European Journal of Immunology. 22: 1651-4. PMID 1318201 DOI: 10.1002/Eji.1830220647 |
0.57 |
|
| 1991 |
Neefjes JJ, Schumacher TN, Ploegh HL. Assembly and intracellular transport of major histocompatibility complex molecules. Current Opinion in Cell Biology. 3: 601-9. PMID 1837724 DOI: 10.1016/0955-0674(91)90029-X |
0.62 |
|
| 1991 |
Schumacher TN, De Bruijn ML, Vernie LN, Kast WM, Melief CJ, Neefjes JJ, Ploegh HL. Peptide selection by MHC class I molecules. Nature. 350: 703-6. PMID 1708852 DOI: 10.1038/350703A0 |
0.679 |
|
| 1990 |
Schumacher TN, Heemels MT, Neefjes JJ, Kast WM, Melief CJ, Ploegh HL. Direct binding of peptide to empty MHC class I molecules on intact cells and in vitro. Cell. 62: 563-7. PMID 2199065 DOI: 10.1016/0092-8674(90)90020-F |
0.665 |
|
| 1990 |
Ljunggren HG, Stam NJ, Ohlén C, Neefjes JJ, Höglund P, Heemels MT, Bastin J, Schumacher TN, Townsend A, Kärre K. Empty MHC class I molecules come out in the cold. Nature. 346: 476-80. PMID 2198471 DOI: 10.1038/346476A0 |
0.553 |
|
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