Sebastian Pomplun - Publications

Affiliations: 
Massachusetts Institute of Technology, Cambridge, MA, United States 
Area:
Bioorganic chemistry, combinatorial drug discovery, chemical biology,

17 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Charalampidou A, Nehls T, Meyners C, Gandhesiri S, Pomplun S, Pentelute BL, Lermyte F, Hausch F. Automated Flow Peptide Synthesis Enables Engineering of Proteins with Stabilized Transient Binding Pockets. Acs Central Science. 10: 649-657. PMID 38559286 DOI: 10.1021/acscentsci.3c01283  0.675
2024 Stransky F, Kostrz D, Follenfant M, Pomplun S, Meyners C, Strick T, Hausch F, Gosse C. Use of DNA forceps to measure receptor-ligand dissociation equilibrium constants in a single-molecule competition assay. Methods in Enzymology. 694: 51-82. PMID 38492958 DOI: 10.1016/bs.mie.2024.01.010  0.547
2024 Ellenbroek BD, Kahler JP, Evers SR, Pomplun SJ. Synthetic Peptides: Promising Modalities for the Targeting of Disease-Related Nucleic Acids. Angewandte Chemie (International Ed. in English). e202401704. PMID 38456368 DOI: 10.1002/anie.202401704  0.307
2021 Kolos JM, Pomplun S, Jung S, Rieß B, Purder PL, Voll AM, Merz S, Gnatzy M, Geiger TM, Quist-Løkken I, Jatzlau J, Knaus P, Holien T, Bracher A, Meyners C, et al. Picomolar FKBP inhibitors enabled by a single water-displacing methyl group in bicyclic [4.3.1] aza-amides. Chemical Science. 12: 14758-14765. PMID 34820091 DOI: 10.1039/d1sc04638a  0.643
2021 Pomplun S, Jbara M, Schissel CK, Wilson Hawken S, Boija A, Li C, Klein I, Pentelute BL. Parallel Automated Flow Synthesis of Covalent Protein Complexes That Can Inhibit MYC-Driven Transcription. Acs Central Science. 7: 1408-1418. PMID 34471684 DOI: 10.1021/acscentsci.1c00663  0.672
2021 Jbara M, Pomplun S, Schissel CK, Hawken SW, Boija A, Klein I, Rodriguez J, Buchwald SL, Pentelute BL. Engineering Bioactive Dimeric Transcription Factor Analogs via Palladium Rebound Reagents. Journal of the American Chemical Society. PMID 34289685 DOI: 10.1021/jacs.1c05666  0.685
2021 Pomplun S, Jbara M, Quartararo AJ, Zhang G, Brown JS, Lee YC, Ye X, Hanna S, Pentelute BL. Discovery of High-Affinity Peptide Binders for the SARS-CoV-2 Spike Protein. Acs Central Science. 7: 156-163. PMID 33527085 DOI: 10.1021/acscentsci.0c01309  0.717
2021 Pomplun S. Targeting the SARS-CoV-2-spike protein: from antibodies to miniproteins and peptides Rsc Medicinal Chemistry. 12: 197-202. DOI: 10.1039/d0md00385a  0.422
2020 Pomplun S. Targeting the SARS-CoV-2-spike protein: from antibodies to miniproteins and peptides. Rsc Medicinal Chemistry. 12: 197-202. PMID 34041482 DOI: 10.1039/d0md00385a  0.471
2020 Pomplun S, Gates ZP, Zhang G, Quartararo AJ, Pentelute BL. Discovery of Nucleic Acid Binding Molecules from Combinatorial Biohybrid Nucleobase Peptide Libraries. Journal of the American Chemical Society. 142: 19642-19651. PMID 33166454 DOI: 10.1021/jacs.0c08964  0.684
2020 Pomplun S, Shugrue CR, Schmitt AM, Schissel CK, Farquhar CE, Pentelute BL. Secondary Amino Alcohols: Traceless Cleavable Linkers for Use in Affinity Capture and Release. Angewandte Chemie (International Ed. in English). 59: 11566-11572. PMID 32227406 DOI: 10.1002/Anie.202003478  0.709
2019 Pomplun S, Mohamed MY, Oelschlaegel T, Wellner C, Bergmann F. Efficient Pictet Spengler Bioconjugation with N-Substituted Pyrrolyl Alanine Derivatives. Angewandte Chemie (International Ed. in English). PMID 30653800 DOI: 10.1002/anie.201814200  0.293
2018 Pomplun S, Sippel C, Hähle A, Tay D, Shima K, Klages A, Ünal CM, Rieß B, Toh HT, Hansen G, Yoon HS, Bracher A, Preiser PR, Rupp J, Steinert M, et al. Chemogenomic profiling of human and microbial FK506-binding proteins. Journal of Medicinal Chemistry. PMID 29578710 DOI: 10.1021/Acs.Jmedchem.8B00137  0.673
2015 Feng X, Pomplun S, Hausch F. Recent Progress in FKBP Ligand Development. Current Molecular Pharmacology. 9: 27-36. PMID 25986570 DOI: 10.2174/1874467208666150519113313  0.642
2015 Pomplun S, Wang Y, Kirschner A, Kozany C, Bracher A, Hausch F. Rational design and asymmetric synthesis of potent and neurotrophic ligands for FK506-binding proteins (FKBPs). Angewandte Chemie (International Ed. in English). 54: 345-8. PMID 25412894 DOI: 10.1002/Anie.201408776  0.7
2014 Cuboni S, Devigny C, Hoogeland B, Strasser A, Pomplun S, Hauger B, Höfner G, Wanner KT, Eder M, Buschauer A, Holsboer F, Hausch F. Loratadine and analogues: discovery and preliminary structure-activity relationship of inhibitors of the amino acid transporter B(0)AT2. Journal of Medicinal Chemistry. 57: 9473-9. PMID 25318072 DOI: 10.1021/Jm501086V  0.6
2014 Pomplun S, Wang Y, Kirschner A, Kozany C, Bracher A, Hausch F. Rationales Design und asymmetrische Synthese potenter neuritotropher Liganden für FK506-bindende Proteine (FKBPs) Angewandte Chemie. 127: 352-355. DOI: 10.1002/Ange.201408776  0.61
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