Michelle F. Paguio, Ph.D.

Affiliations: 
2009 Chemistry Georgetown University, Washington, DC 
Area:
Parasitology, Biochemistry, Molecular Biology
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"Michelle Paguio"

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Paul D. Roepe grad student 2009 Georgetown
 (Biochemical and biophysical analysis of recombinant Plasmodium falciparum chloroquine resistance transporter (PfCRT).)
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Publications

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Gaviria D, Paguio MF, Turnbull LB, et al. (2013) A process similar to autophagy is associated with cytocidal chloroquine resistance in Plasmodium falciparum. Plos One. 8: e79059
Brunner R, Ng CL, Aissaoui H, et al. (2013) UV-triggered affinity capture identifies interactions between the Plasmodium falciparum multidrug resistance protein 1 (PfMDR1) and antimalarial agents in live parasitized cells. The Journal of Biological Chemistry. 288: 22576-83
Paguio MF, Bogle KL, Roepe PD. (2011) Plasmodium falciparum resistance to cytocidal versus cytostatic effects of chloroquine. Molecular and Biochemical Parasitology. 178: 1-6
Cabrera M, Paguio MF, Xie C, et al. (2009) Reduced digestive vacuolar accumulation of chloroquine is not linked to resistance to chloroquine toxicity. Biochemistry. 48: 11152-4
Cabrera M, Natarajan J, Paguio MF, et al. (2009) Chloroquine transport in Plasmodium falciparum. 1. Influx and efflux kinetics for live trophozoite parasites using a novel fluorescent chloroquine probe. Biochemistry. 48: 9471-81
Paguio MF, Cabrera M, Roepe PD. (2009) Chloroquine transport in Plasmodium falciparum. 2. Analysis of PfCRT-mediated drug transport using proteoliposomes and a fluorescent chloroquine probe. Biochemistry. 48: 9482-91
Lekostaj JK, Natarajan JK, Paguio MF, et al. (2008) Photoaffinity labeling of the Plasmodium falciparum chloroquine resistance transporter with a novel perfluorophenylazido chloroquine. Biochemistry. 47: 10394-406
Zhang H, Paguio M, Roepe PD. (2004) The antimalarial drug resistance protein Plasmodium falciparum chloroquine resistance transporter binds chloroquine. Biochemistry. 43: 8290-6
Bennett TN, Paguio M, Gligorijevic B, et al. (2004) Novel, rapid, and inexpensive cell-based quantification of antimalarial drug efficacy. Antimicrobial Agents and Chemotherapy. 48: 1807-10
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