Pierre-Olivier Hardy, Ph.D.

Affiliations: 
2013 Microbiology, Immunology, and Infectious Diseases University of Calgary, Calgary, Alberta, Canada 
Area:
Microbiology, Molecular Biology, Genetics
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"Pierre-Olivier Hardy"

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George Chaconas grad student 2013 University of Calgary
 (Genetic analysis and the effect upon mouse infection of nucleic acid metabolizing genes in the Lyme disease spirochete.)
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Publications

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Lee WY, Sanz MJ, Wong CH, et al. (2014) Invariant natural killer T cells act as an extravascular cytotoxic barrier for joint-invading Lyme Borrelia. Proceedings of the National Academy of Sciences of the United States of America. 111: 13936-41
Salman-Dilgimen A, Hardy PO, Radolf JD, et al. (2013) HrpA, an RNA helicase involved in RNA processing, is required for mouse infectivity and tick transmission of the Lyme disease spirochete. Plos Pathogens. 9: e1003841
Hardy PO, Chaconas G. (2013) The nucleotide excision repair system of Borrelia burgdorferi is the sole pathway involved in repair of DNA damage by UV light. Journal of Bacteriology. 195: 2220-31
Moriarty TJ, Shi M, Lin YP, et al. (2012) Vascular binding of a pathogen under shear force through mechanistically distinct sequential interactions with host macromolecules. Molecular Microbiology. 86: 1116-31
Salman-Dilgimen A, Hardy PO, Dresser AR, et al. (2011) HrpA, a DEAH-box RNA helicase, is involved in global gene regulation in the Lyme disease spirochete. Plos One. 6: e22168
Dresser AR, Hardy PO, Chaconas G. (2009) Investigation of the genes involved in antigenic switching at the vlsE locus in Borrelia burgdorferi: an essential role for the RuvAB branch migrase. Plos Pathogens. 5: e1000680
Hardy PO, Diallo TO, Matte C, et al. (2009) Roles of phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase in the regulation of protein kinase C-alpha activation in interferon-gamma-stimulated macrophages. Immunology. 128: e652-60
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