Brigitte N. Goulet, Ph.D.

Affiliations: 
2004 McGill University, Montreal, QC, Canada 
Area:
Cell Biology, Oncology
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"Brigitte Goulet"

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Alain Nepveu grad student 2004 McGill
 (Alternative mechanisms to generate short CDP /Cux isoforms in cancer cells.)
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Publications

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Goulet B, Chan G, Chambers AF, et al. (2012) An emerging role for the nuclear localization of maspin in the suppression of tumor progression and metastasis. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 90: 22-38
Goulet B, Markovic Y, Leduy L, et al. (2008) Proteolytic processing of cut homeobox 1 by neutrophil elastase in the MV4;11 myeloid leukemia cell line. Molecular Cancer Research : McR. 6: 644-53
Goulet B, Sansregret L, Leduy L, et al. (2007) Increased expression and activity of nuclear cathepsin L in cancer cells suggests a novel mechanism of cell transformation. Molecular Cancer Research : McR. 5: 899-907
Truscott M, Denault JB, Goulet B, et al. (2007) Carboxyl-terminal proteolytic processing of CUX1 by a caspase enables transcriptional activation in proliferating cells. The Journal of Biological Chemistry. 282: 30216-26
Goulet B, Truscott M, Nepveu A. (2006) A novel proteolytically processed CDP/Cux isoform of 90 kDa is generated by cathepsin L. Biological Chemistry. 387: 1285-93
Sansregret L, Goulet B, Harada R, et al. (2006) The p110 isoform of the CDP/Cux transcription factor accelerates entry into S phase. Molecular and Cellular Biology. 26: 2441-55
Goulet B, Nepveu A. (2004) Complete and limited proteolysis in cell cycle progression. Cell Cycle (Georgetown, Tex.). 3: 986-9
Goulet B, Baruch A, Moon NS, et al. (2004) A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor. Molecular Cell. 14: 207-19
Truscott M, Raynal L, Premdas P, et al. (2003) CDP/Cux stimulates transcription from the DNA polymerase alpha gene promoter. Molecular and Cellular Biology. 23: 3013-28
Goulet B, Watson P, Poirier M, et al. (2002) Characterization of a tissue-specific CDP/Cux isoform, p75, activated in breast tumor cells. Cancer Research. 62: 6625-33
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