Denise M. Monack, Ph.D. - Publications

Bacterial pathogenicity

59 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Sana TG, Flaugnatti N, Lugo KA, Lam LH, Jacobson A, Baylot V, Durand E, Journet L, Cascales E, Monack DM. Salmonella Typhimurium utilizes a T6SS-mediated antibacterial weapon to establish in the host gut. Proceedings of the National Academy of Sciences of the United States of America. PMID 27503894 DOI: 10.1073/pnas.1608858113  1
2016 Sanman LE, Qian Y, Eisele NA, Ng TM, van der Linden WA, Monack DM, Weerapana E, Bogyo M. Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death. Elife. 5. PMID 27011353 DOI: 10.7554/eLife.13663  1
2015 Hoy YE, Bik EM, Lawley TD, Holmes SP, Monack DM, Theriot JA, Relman DA. Variation in Taxonomic Composition of the Fecal Microbiota in an Inbred Mouse Strain across Individuals and Time. Plos One. 10: e0142825. PMID 26565698 DOI: 10.1371/journal.pone.0142825  1
2015 Storek KM, Gertsvolf NA, Ohlson MB, Monack DM. cGAS and Ifi204 cooperate to produce type I IFNs in response to Francisella infection. Journal of Immunology (Baltimore, Md. : 1950). 194: 3236-45. PMID 25710914 DOI: 10.4049/jimmunol.1402764  1
2014 Gopinath S, Lichtman JS, Bouley DM, Elias JE, Monack DM. Role of disease-associated tolerance in infectious superspreaders. Proceedings of the National Academy of Sciences of the United States of America. 111: 15780-5. PMID 25331868 DOI: 10.1073/pnas.1409968111  1
2014 Feld GK, El-Etr S, Corzett MH, Hunter MS, Belhocine K, Monack DM, Frank M, Segelke BW, Rasley A. Structure and function of REP34 implicates carboxypeptidase activity in Francisella tularensis host cell invasion. The Journal of Biological Chemistry. 289: 30668-79. PMID 25231992 DOI: 10.1074/jbc.M114.599381  1
2014 McLaughlin LM, Xu H, Carden SE, Fisher S, Reyes M, Heilshorn SC, Monack DM. A microfluidic-based genetic screen to identify microbial virulence factors that inhibit dendritic cell migration. Integrative Biology : Quantitative Biosciences From Nano to Macro. 6: 438-49. PMID 24599496 DOI: 10.1039/c3ib40177d  1
2013 Ng KM, Ferreyra JA, Higginbottom SK, Lynch JB, Kashyap PC, Gopinath S, Naidu N, Choudhury B, Weimer BC, Monack DM, Sonnenburg JL. Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens. Nature. 502: 96-9. PMID 23995682 DOI: 10.1038/nature12503  1
2013 Eisele NA, Ruby T, Jacobson A, Manzanillo PS, Cox JS, Lam L, Mukundan L, Chawla A, Monack DM. Salmonella require the fatty acid regulator PPARδ for the establishment of a metabolic environment essential for long-term persistence. Cell Host & Microbe. 14: 171-82. PMID 23954156 DOI: 10.1016/j.chom.2013.07.010  1
2013 Xavier MN, Winter MG, Spees AM, den Hartigh AB, Nguyen K, Roux CM, Silva TM, Atluri VL, Kerrinnes T, Keestra AM, Monack DM, Luciw PA, Eigenheer RA, Bäumler AJ, Santos RL, et al. PPARγ-mediated increase in glucose availability sustains chronic Brucella abortus infection in alternatively activated macrophages. Cell Host & Microbe. 14: 159-70. PMID 23954155 DOI: 10.1016/j.chom.2013.07.009  1
2013 Monack DM, Hultgren SJ. The complex interactions of bacterial pathogens and host defenses. Current Opinion in Microbiology. 16: 1-3. PMID 23518336 DOI: 10.1016/j.mib.2013.03.001  1
2013 Gomez JA, Wapinski OL, Yang YW, Bureau JF, Gopinath S, Monack DM, Chang HY, Brahic M, Kirkegaard K. The NeST long ncRNA controls microbial susceptibility and epigenetic activation of the interferon-γ locus. Cell. 152: 743-54. PMID 23415224 DOI: 10.1016/j.cell.2013.01.015  1
2012 Broz P, Ruby T, Belhocine K, Bouley DM, Kayagaki N, Dixit VM, Monack DM. Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1 Nature. 490: 288-291. PMID 22895188 DOI: 10.1038/nature11419  1
2012 Broz P, Ohlson MB, Monack DM. Innate immune response to Salmonella typhimurium, a model enteric pathogen. Gut Microbes. 3: 62-70. PMID 22198618 DOI: 10.4161/gmic.19141  1
2012 Chin CY, Monack DM, Nathan S. Delayed activation of host innate immune pathways in streptozotocin-induced diabetic hosts leads to more severe disease during infection with Burkholderia pseudomallei. Immunology. 135: 312-32. PMID 22136109 DOI: 10.1111/j.1365-2567.2011.03544.x  1
2011 Reif KE, Palmer GH, Ueti MW, Scoles GA, Margolis JJ, Monack DM, Noh SM. Dermacentor andersoni transmission of Francisella tularensis subsp. novicida reflects bacterial colonization, dissemination, and replication coordinated with tick feeding Infection and Immunity. 79: 4941-4946. PMID 21930762 DOI: 10.1128/IAI.05676-11  1
2011 Alegado RA, Chin CY, Monack DM, Tan MW. The two-component sensor kinase KdpD is required for Salmonella typhimurium colonization of Caenorhabditis elegans and survival in macrophages. Cellular Microbiology. 13: 1618-37. PMID 21790938 DOI: 10.1111/j.1462-5822.2011.01645.x  1
2011 Arpaia N, Godec J, Lau L, Sivick KE, McLaughlin LM, Jones MB, Dracheva T, Peterson SN, Monack DM, Barton GM. TLR signaling is required for Salmonella typhimurium virulence. Cell. 144: 675-88. PMID 21376231 DOI: 10.1016/j.cell.2011.01.031  1
2011 Lindemann SR, Peng K, Long ME, Hunt JR, Apicella MA, Monack DM, Allen LA, Jones BD. Francisella tularensis Schu S4 O-antigen and capsule biosynthesis gene mutants induce early cell death in human macrophages. Infection and Immunity. 79: 581-94. PMID 21078861 DOI: 10.1128/IAI.00863-10  1
2010 Broz P, von Moltke J, Jones JW, Vance RE, Monack DM. Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing. Cell Host & Microbe. 8: 471-83. PMID 21147462 DOI: 10.1016/j.chom.2010.11.007  1
2010 Moule MG, Monack DM, Schneider DS. Reciprocal analysis of Francisella novicida infections of a Drosophila melanogaster model reveal host-pathogen conflicts mediated by reactive oxygen and imd-regulated innate immune response. Plos Pathogens. 6: e1001065. PMID 20865166 DOI: 10.1371/journal.ppat.1001065  1
2010 Broz P, Newton K, Lamkanfi M, Mariathasan S, Dixit VM, Monack DM. Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella Journal of Experimental Medicine. 207: 1745-1755. PMID 20603313 DOI: 10.1084/jem.20100257  1
2010 Jones JW, Kayagaki N, Broz P, Henry T, Newton K, O'Rourke K, Chan S, Dong J, Qu Y, Roose-Girma M, Dixit VM, Monack DM. Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis Proceedings of the National Academy of Sciences of the United States of America. 107: 9771-9776. PMID 20457908 DOI: 10.1073/pnas.1003738107  1
2010 Peng K, Monack DM. Indoleamine 2,3-dioxygenase 1 is a lung-specific innate immune defense mechanism that inhibits growth of Francisella tularensis tryptophan auxotrophs. Infection and Immunity. 78: 2723-33. PMID 20385761 DOI: 10.1128/IAI.00008-10  1
2010 Henry T, Kirimanjeswara GS, Ruby T, Jones JW, Peng K, Perret M, Ho L, Sauer JD, Iwakura Y, Metzger DW, Monack DM. Type I IFN signaling constrains IL-17A/F secretion by gammadelta T cells during bacterial infections. Journal of Immunology (Baltimore, Md. : 1950). 184: 3755-67. PMID 20176744 DOI: 10.4049/jimmunol.0902065  1
2010 Ghosn EE, Cassado AA, Govoni GR, Fukuhara T, Yang Y, Monack DM, Bortoluci KR, Almeida SR, Herzenberg LA, Herzenberg LA. Two physically, functionally, and developmentally distinct peritoneal macrophage subsets. Proceedings of the National Academy of Sciences of the United States of America. 107: 2568-73. PMID 20133793 DOI: 10.1073/pnas.0915000107  1
2010 Margolis JJ, El-Etr S, Joubert LM, Moore E, Robison R, Rasley A, Spormann AM, Monack DM. Contributions of Francisella tularensis subsp. novicida chitinases and Sec secretion system to biofilm formation on chitin. Applied and Environmental Microbiology. 76: 596-608. PMID 19948864 DOI: 10.1128/AEM.02037-09  1
2009 Winter SE, Thiennimitr P, Nuccio SP, Haneda T, Winter MG, Wilson RP, Russell JM, Henry T, Tran QT, Lawhon SD, Gomez G, Bevins CL, Rüssmann H, Monack DM, Adams LG, et al. Contribution of flagellin pattern recognition to intestinal inflammation during Salmonella enterica serotype typhimurium infection. Infection and Immunity. 77: 1904-16. PMID 19237529 DOI: 10.1128/IAI.01341-08  1
2008 Lightfield KL, Persson J, Brubaker SW, Witte CE, von Moltke J, Dunipace EA, Henry T, Sun YH, Cado D, Dietrich WF, Monack DM, Tsolis RM, Vance RE. Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin. Nature Immunology. 9: 1171-8. PMID 18724372 DOI: 10.1038/ni.1646  1
2008 Lawley TD, Bouley DM, Hoy YE, Gerke C, Relman DA, Monack DM. Host transmission of Salmonella enterica serovar Typhimurium is controlled by virulence factors and indigenous intestinal microbiota. Infection and Immunity. 76: 403-16. PMID 17967858 DOI: 10.1128/IAI.01189-07  1
2007 Henry T, Monack DM. Activation of the inflammasome upon Francisella tularensis infection: interplay of innate immune pathways and virulence factors. Cellular Microbiology. 9: 2543-51. PMID 17662071 DOI: 10.1111/j.1462-5822.2007.01022.x  1
2007 Henry T, Brotcke A, Weiss DS, Thompson LJ, Monack DM. Type I interferon signaling is required for activation of the inflammasome during Francisella infection. The Journal of Experimental Medicine. 204: 987-94. PMID 17452523 DOI: 10.1084/jem.20062665  1
2007 Weiss DS, Henry T, Monack DM. Francisella tularensis: activation of the inflammasome. Annals of the New York Academy of Sciences. 1105: 219-37. PMID 17395724 DOI: 10.1196/annals.1409.005  1
2007 Weiss DS, Brotcke A, Henry T, Margolis JJ, Chan K, Monack DM. In vivo negative selection screen identifies genes required for Francisella virulence. Proceedings of the National Academy of Sciences of the United States of America. 104: 6037-42. PMID 17389372 DOI: 10.1073/pnas.0609675104  1
2007 Mariathasan S, Monack DM. Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation. Nature Reviews. Immunology. 7: 31-40. PMID 17186029 DOI: 10.1038/nri1997  1
2006 Brotcke A, Weiss DS, Kim CC, Chain P, Malfatti S, Garcia E, Monack DM. Identification of MglA-regulated genes reveals novel virulence factors in Francisella tularensis. Infection and Immunity. 74: 6642-55. PMID 17000729 DOI: 10.1128/IAI.01250-06  1
2006 Raupach B, Peuschel SK, Monack DM, Zychlinsky A. Caspase-1-mediated activation of interleukin-1beta (IL-1beta) and IL-18 contributes to innate immune defenses against Salmonella enterica serovar Typhimurium infection. Infection and Immunity. 74: 4922-6. PMID 16861683 DOI: 10.1128/IAI.00417-06  1
2006 Lawley TD, Chan K, Thompson LJ, Kim CC, Govoni GR, Monack DM. Genome-wide screen for Salmonella genes required for long-term systemic infection of the mouse. Plos Pathogens. 2: e11. PMID 16518469 DOI: 10.1371/journal.ppat.0020011  1
2006 Mariathasan S, Weiss DS, Newton K, McBride J, O'Rourke K, Roose-Girma M, Lee WP, Weinrauch Y, Monack DM, Dixit VM. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature. 440: 228-32. PMID 16407890 DOI: 10.1038/nature04515  1
2005 Zhou H, Monack DM, Kayagaki N, Wertz I, Yin J, Wolf B, Dixit VM. Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-κB activation Journal of Experimental Medicine. 202: 1327-1332. PMID 16301742 DOI: 10.1084/jem.20051194  1
2005 Mariathasan S, Weiss DS, Dixit VM, Monack DM. Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis. The Journal of Experimental Medicine. 202: 1043-9. PMID 16230474 DOI: 10.1084/jem.20050977  1
2004 Monack DM, Mueller A, Falkow S. Persistent bacterial infections: the interface of the pathogen and the host immune system. Nature Reviews. Microbiology. 2: 747-65. PMID 15372085 DOI: 10.1038/nrmicro955  1
2004 Mariathasan S, Hewton K, Monack DM, Vucic D, French DM, Lee WP, Roose-Girma M, Erickson S, Dixit VM. Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf Nature. 430: 213-218. PMID 15190255 DOI: 10.1038/nature02664  1
2004 Monack DM, Bouley DM, Falkow S. Salmonella typhimurium persists within macrophages in the mesenteric lymph nodes of chronically infected Nramp1+/+ mice and can be reactivated by IFNgamma neutralization. The Journal of Experimental Medicine. 199: 231-41. PMID 14734525 DOI: 10.1084/jem.20031319  1
2003 Detweiler CS, Monack DM, Brodsky IE, Mathew H, Falkow S. virK, somA and rcsC are important for systemic Salmonella enterica serovar Typhimurium infection and cationic peptide resistance. Molecular Microbiology. 48: 385-400. PMID 12675799 DOI: 10.1046/j.1365-2958.2003.03455.x  1
2002 Catron DM, Sylvester MD, Lange Y, Kadekoppala M, Jones BD, Monack DM, Falkow S, Haldar K. The Salmonella-containing vacuole is a major site of intracellular cholesterol accumulation and recruits the GPI-anchored protein CD55. Cellular Microbiology. 4: 315-28. PMID 12067317 DOI: 10.1046/j.1462-5822.2002.00198.x  1
2001 Monack DM, Navarre WW, Falkow S. Salmonella-induced macrophage death: the role of caspase-1 in death and inflammation. Microbes and Infection / Institut Pasteur. 3: 1201-12. PMID 11755408 DOI: 10.1016/S1286-4579(01)01480-0  1
2001 Monack DM, Detweiler CS, Falkow S. Salmonella pathogenicity island 2-dependent macrophage death is mediated in part by the host cysteine protease caspase-1. Cellular Microbiology. 3: 825-37. PMID 11736994 DOI: 10.1046/j.1462-5822.2001.00162.x  1
2001 Monack DM, Theriot JA. Actin-based motility is sufficient for bacterial membrane protrusion formation and host cell uptake. Cellular Microbiology. 3: 633-47. PMID 11553015 DOI: 10.1046/j.1462-5822.2001.00143.x  1
2000 Monack DM, Hersh D, Ghori N, Bouley D, Zychlinsky A, Falkow S. Salmonella exploits caspase-1 to colonize Peyer's patches in a murine typhoid model. The Journal of Experimental Medicine. 192: 249-58. PMID 10899911 DOI: 10.1084/jem.192.2.249  1
1999 Hersh D, Monack DM, Smith MR, Ghori N, Falkow S, Zychlinsky A. The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1. Proceedings of the National Academy of Sciences of the United States of America. 96: 2396-401. PMID 10051653 DOI: 10.1073/pnas.96.5.2396  1
1998 Monack DM, Mecsas J, Bouley D, Falkow S. Yersinia-induced apoptosis in vivo aids in the establishment of a systemic infection of mice. The Journal of Experimental Medicine. 188: 2127-37. PMID 9841926 DOI: 10.1084/jem.188.11.2127  1
1998 Cirillo DM, Valdivia RH, Monack DM, Falkow S. Macrophage-dependent induction of the Salmonella pathogenicity island 2 type III secretion system and its role in intracellular survival. Molecular Microbiology. 30: 175-88. PMID 9786194 DOI: 10.1046/j.1365-2958.1998.01048.x  1
1997 Monack DM, Mecsas J, Ghori N, Falkow S. Yersinia signals macrophages to undergo apoptosis and YopJ is necessary for this cell death. Proceedings of the National Academy of Sciences of the United States of America. 94: 10385-90. PMID 9294220 DOI: 10.1073/pnas.94.19.10385  1
1996 Monack DM, Raupach B, Hromockyj AE, Falkow S. Salmonella typhimurium invasion induces apoptosis in infected macrophages. Proceedings of the National Academy of Sciences of the United States of America. 93: 9833-8. PMID 8790417 DOI: 10.1073/pnas.93.18.9833  1
1993 Monack DM, Falkow S. Cloning of Bordetella bronchiseptica urease genes and analysis of colonization by a urease-negative mutant strain in a guinea-pig model. Molecular Microbiology. 10: 545-53. PMID 7968532 DOI: 10.1111/j.1365-2958.1993.tb00926.x  1
1992 Akerley BJ, Monack DM, Falkow S, Miller JF. The bvgAS locus negatively controls motility and synthesis of flagella in Bordetella bronchiseptica. Journal of Bacteriology. 174: 980-90. PMID 1370665  1
1991 Aricò B, Scarlato V, Monack DM, Falkow S, Rappuoli R. Structural and genetic analysis of the bvg locus in Bordetella species. Molecular Microbiology. 5: 2481-91. PMID 1791760  1
1989 Monack DM, Arico B, Rappuoli R, Falkow S. Phase variants of Bordetella bronchiseptica arise by spontaneous deletions in the vir locus. Molecular Microbiology. 3: 1719-28. PMID 2560120 DOI: 10.1111/j.1365-2958.1989.tb00157.x  1
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