| Year |
Citation |
Score |
| 2023 |
Wang QQ, Wang L, Zhang WB, Tang CP, Chen XQ, Zheng YM, Yao S, Gao ZB, Ye Y. Naphthylisoquinoline alkaloids, a new structural template inhibitor of Nav1.7 sodium channel. Acta Pharmacologica Sinica. PMID 37142682 DOI: 10.1038/s41401-023-01084-9 |
0.394 |
|
| 2022 |
Guo QB, Zhan L, Xu HY, Gao ZB, Zheng YM. SCN8A epileptic encephalopathy mutations display a gain-of-function phenotype and divergent sensitivity to antiepileptic drugs. Acta Pharmacologica Sinica. PMID 35902765 DOI: 10.1038/s41401-022-00955-x |
0.332 |
|
| 2022 |
Liu LX, Gu RR, Jin Y, Chen XQ, Li XW, Zheng YM, Gao ZB, Guo YW. Diversity-oriented synthesis of marine polybrominated diphenyl ethers as potential KCNQ potassium channel activators. Bioorganic Chemistry. 126: 105909. PMID 35661526 DOI: 10.1016/j.bioorg.2022.105909 |
0.374 |
|
| 2021 |
Wang Y, Fang S, Wu Y, Cheng X, Zhang LK, Shen XR, Li SQ, Xu JR, Shang WJ, Gao ZB, Xia BQ. Discovery of SARS-CoV-2-E channel inhibitors as antiviral candidates. Acta Pharmacologica Sinica. PMID 34294887 DOI: 10.1038/s41401-021-00732-2 |
0.383 |
|
| 2020 |
Xie ZQ, Tian XT, Zheng YM, Zhan L, Chen XQ, Xin XM, Huang CG, Gao ZB. Antiepileptic geissoschizine methyl ether is an inhibitor of multiple neuronal channels. Acta Pharmacologica Sinica. PMID 31911638 DOI: 10.1038/S41401-019-0327-4 |
0.442 |
|
| 2019 |
Liao P, Qiu Y, Mo Y, Fu J, Song Z, Huang L, Bai S, Wang Y, Zhu JJ, Tian F, Chen Z, Pan N, Sun EY, Yang L, Lan X, ... ... Gao Z, et al. Selective activation of TWIK-related acid-sensitive K 3 subunit-containing channels is analgesic in rodent models. Science Translational Medicine. 11. PMID 31748231 DOI: 10.1126/Scitranslmed.Aaw8434 |
0.449 |
|
| 2019 |
Wang JT, Zheng YM, Chen YT, Gu M, Gao ZB, Nan FJ. Discovery of aryl sulfonamide-selective Nav1.7 inhibitors with a highly hydrophobic ethanoanthracene core. Acta Pharmacologica Sinica. PMID 31316182 DOI: 10.1038/S41401-019-0267-Z |
0.46 |
|
| 2019 |
Tian F, Qiu Y, Lan X, Li M, Yang H, Gao Z. A small molecular compound selectively activates K2P channel TASK-3 by acting at two distant clusters of residues. Molecular Pharmacology. PMID 31015283 DOI: 10.1124/Mol.118.115303 |
0.38 |
|
| 2019 |
Wang L, Qiao GH, Hu HN, Gao ZB, Nan FJ. Discovery of Novel Retigabine Derivatives as Potent KCNQ4 and KCNQ5 Channel Agonists with Improved Specificity. Acs Medicinal Chemistry Letters. 10: 27-33. PMID 30655942 DOI: 10.1021/Acsmedchemlett.8B00315 |
0.492 |
|
| 2018 |
Rodier E, Niday Z, Doci K, Wang L, Nan FJ, Gao ZB, Tzingounis AV. Inhibition of KCNQ2/3 channels by HN38 and XE991 depends on the conformation of the outer vestibule. Molecular Pharmacology. PMID 30504241 DOI: 10.1124/Mol.118.113407 |
0.501 |
|
| 2018 |
Li YF, Zheng YM, Yu Y, Gan Y, Gao ZB. Inhibitory effects of lappaconitine on the neuronal isoforms of voltage-gated sodium channels. Acta Pharmacologica Sinica. PMID 29991710 DOI: 10.1038/S41401-018-0067-X |
0.559 |
|
| 2018 |
Bai F, Pi X, Li P, Zhou P, Yang H, Wang X, Li M, Gao Z, Jiang H. A Statistical Thermodynamic Model for Ligands Interacting With Ion Channels: Theoretical Model and Experimental Validation of the KCNQ2 Channel. Frontiers in Pharmacology. 9: 150. PMID 29593528 DOI: 10.3389/Fphar.2018.00150 |
0.456 |
|
| 2018 |
Qiu B, Xia B, Zhou Q, Lu Y, He M, Hasegawa K, Ma Z, Zhang F, Gu L, Mao Q, Wang F, Zhao S, Gao Z, Liao J. Succinate-acetate permease from Citrobacter koseri is an anion channel that unidirectionally translocates acetate. Cell Research. 28: 644-654. DOI: 10.2210/Pdb5Ys8/Pdb |
0.375 |
|
| 2017 |
Zheng YM, Wang WF, Li YF, Yu Y, Gao ZB. Enhancing inactivation rather than reducing activation of Nav1.7 channels by a clinically effective analgesic CNV1014802. Acta Pharmacologica Sinica. PMID 29094728 DOI: 10.1038/Aps.2017.151 |
0.578 |
|
| 2017 |
Ding Q, Fang S, Chen X, Wang Y, Li J, Tian F, Xu X, Attali B, Xie X, Gao Z. TRPA1 channel mediates organophosphate-induced delayed neuropathy. Cell Discovery. 3: 17024. PMID 28894590 DOI: 10.1038/Celldisc.2017.24 |
0.435 |
|
| 2017 |
Pi X, Ding Q, Gao Z. A Voltage- to Ligand- Gated Switch in Voltage-Gated Potassium Channels Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.628 |
0.463 |
|
| 2017 |
Lan X, Fan C, Ji W, Tian F, Xu T, Gao Z. Grafting Voltage Sensing Sensitivity and Pharmacology in Potassium Channels Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.1347 |
0.449 |
|
| 2017 |
Zheng Y, Wang W, Gao Z. CNV1014802 Rescues the Paroxysmal Extreme Pain Disorders Nav1.7 Mutants by Restoring Impaired Inactivation Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.1320 |
0.413 |
|
| 2016 |
Lan X, Fan C, Ji W, Tian F, Xu T, Gao Z. Grafting voltage and pharmacological sensitivity in potassium channels. Cell Research. PMID 27174053 DOI: 10.1038/Cr.2016.57 |
0.497 |
|
| 2016 |
Xia B, Fang S, Chen X, Hu H, Chen P, Wang H, Gao Z. MLKL forms cation channels. Cell Research. PMID 27033670 DOI: 10.1038/Cr.2016.26 |
0.402 |
|
| 2016 |
Zhang Q, Gao Z, Yang H. Computer-Aided Drug Discovery and Design Targeting Ion Channels. Current Topics in Medicinal Chemistry. PMID 26975507 DOI: 10.2174/1568026616666160315142346 |
0.433 |
|
| 2016 |
Yue JF, Qiao GH, Liu N, Nan FJ, Gao ZB. Novel KCNQ2 channel activators discovered using fluorescence-based and automated patch-clamp-based high-throughput screening techniques. Acta Pharmacologica Sinica. 37: 105-10. PMID 26725738 DOI: 10.1038/Aps.2015.142 |
0.415 |
|
| 2016 |
Attali B, Gao ZB. Ion channels research in the post-genomic era. Acta Pharmacologica Sinica. 37: 1-3. PMID 26725731 DOI: 10.1038/Aps.2015.144 |
0.496 |
|
| 2015 |
Zheng Y, Xu H, Zhan L, Zhou X, Chen X, Gao Z. Activation of peripheral KCNQ channels relieves gout pain. Pain. 156: 1025-35. PMID 25735002 DOI: 10.1097/J.Pain.0000000000000122 |
0.459 |
|
| 2015 |
Fu J, Gao Z, Shen B, Zhu MX. Canonical transient receptor potential 4 and its small molecule modulators. Science China. Life Sciences. 58: 39-47. PMID 25480324 DOI: 10.1007/S11427-014-4772-5 |
0.32 |
|
| 2015 |
Zhou P, Zhang Y, Xu H, Chen F, Chen X, Li X, Pi X, Wang L, Zhan L, Nan F, Gao Z. P-retigabine: an N-propargyled retigabine with improved brain distribution and enhanced antiepileptic activity. Molecular Pharmacology. 87: 31-8. PMID 25319542 DOI: 10.1124/Mol.114.095190 |
0.324 |
|
| 2014 |
Li P, Chen X, Zhang Q, Zheng Y, Jiang H, Yang H, Gao Z. The human ether-a-go-go-related gene activator NS1643 enhances epilepsy-associated KCNQ channels Journal of Pharmacology and Experimental Therapeutics. 351: 596-604. PMID 25232191 DOI: 10.1124/Jpet.114.217703 |
0.479 |
|
| 2014 |
Ji X, Xia C, Wang J, Su M, Zhang L, Dong T, Li Z, Wan X, Li J, Li J, Zhao L, Gao Z, Jiang H, Liu H. Design, synthesis and biological evaluation of 4-fluoropyrrolidine-2-carbonitrile and octahydrocyclopenta[b]pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors. European Journal of Medicinal Chemistry. 86: 242-56. PMID 25164763 DOI: 10.1016/J.Ejmech.2014.08.059 |
0.327 |
|
| 2014 |
Wan X, Lu Y, Chen X, Xiong J, Zhou Y, Li P, Xia B, Li M, Zhu MX, Gao Z. Bimodal voltage dependence of TRPA1: Mutations of a key pore helix residue reveal strong intrinsic voltage-dependent inactivation Pflugers Archiv European Journal of Physiology. 466: 1273-1287. PMID 24092046 DOI: 10.1007/S00424-013-1345-6 |
0.47 |
|
| 2014 |
Li P, Chen Z, Yang H, Gao Z, Jiang H, Li M. An Activator Binding Site in the Gating Charge Pathway of KCNQ2 Channel Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.827 |
0.43 |
|
| 2013 |
Zhang Q, Zhou P, Chen Z, Li M, Jiang H, Gao Z, Yang H. Dynamic PIP2 interactions with voltage sensor elements contribute to KCNQ2 channel gating Proceedings of the National Academy of Sciences of the United States of America. 110: 20093-20098. PMID 24277843 DOI: 10.1073/Pnas.1312483110 |
0.446 |
|
| 2013 |
Hu HN, Zhou PZ, Chen F, Li M, Nan FJ, Gao ZB. Discovery of a retigabine derivative that inhibits KCNQ2 potassium channels. Acta Pharmacologica Sinica. 34: 1359-66. PMID 23933653 DOI: 10.1038/aps.2013.79 |
0.435 |
|
| 2013 |
Li P, Chen Z, Xu H, Sun H, Li H, Liu H, Yang H, Gao Z, Jiang H, Li M. The gating charge pathway of an epilepsy-associated potassium channel accommodates chemical ligands. Cell Research. 23: 1106-18. PMID 23797855 DOI: 10.1038/Cr.2013.82 |
0.416 |
|
| 2013 |
Zhou P, Yu H, Gu M, Nan FJ, Gao Z, Li M. Phosphatidylinositol 4,5-bisphosphate alters pharmacological selectivity for epilepsy-causing KCNQ potassium channels. Proceedings of the National Academy of Sciences of the United States of America. 110: 8726-31. PMID 23650395 DOI: 10.1073/Pnas.1302167110 |
0.425 |
|
| 2013 |
Li P, Zhu J, Kong Q, Jiang B, Wan X, Yue J, Li M, Jiang H, Li J, Gao Z. The ethylene bis-dithiocarbamate fungicide Mancozeb activates voltage-gated KCNQ2 potassium channel. Toxicology Letters. 219: 211-7. PMID 23542819 DOI: 10.1016/J.Toxlet.2013.03.020 |
0.404 |
|
| 2012 |
Zheng Y, Zhu X, Zhou P, Lan X, Xu H, Li M, Gao Z. Hexachlorophene is a potent KCNQ1/KCNE1 potassium channel activator which rescues LQTs mutants. Plos One. 7: e51820. PMID 23251633 DOI: 10.1371/Journal.Pone.0051820 |
0.477 |
|
| 2012 |
Yang H, Gao Z, Li P, Yu K, Yu Y, Xu TL, Li M, Jiang H. A theoretical model for calculating voltage sensitivity of ion channels and the application on Kv1.2 potassium channel. Biophysical Journal. 102: 1815-25. PMID 22768937 DOI: 10.1016/J.Bpj.2012.03.032 |
0.367 |
|
| 2012 |
Li P, Sun HF, Zhou PZ, Ma CY, Hu GY, Jiang HL, Li M, Liu H, Gao ZB. Comparison of the effects of DC031050, a class III antiarrhythmic agent, on hERG channel and three neuronal potassium channels. Acta Pharmacologica Sinica. 33: 728-36. PMID 22609836 DOI: 10.1038/aps.2012.41 |
0.579 |
|
| 2011 |
Zhou PZ, Babcock J, Liu LQ, Li M, Gao ZB. Activation of human ether-a-go-go related gene (hERG) potassium channels by small molecules. Acta Pharmacologica Sinica. 32: 781-8. PMID 21623390 DOI: 10.1038/aps.2011.70 |
0.353 |
|
| 2010 |
Gao Z, Zhang T, Wu M, Xiong Q, Sun H, Zhang Y, Zu L, Wang W, Li M. Isoform-specific prolongation of Kv7 (KCNQ) potassium channel opening mediated by new molecular determinants for drug-channel interactions. The Journal of Biological Chemistry. 285: 28322-32. PMID 20584905 DOI: 10.1074/Jbc.M110.116392 |
0.501 |
|
| 2008 |
Gao Z, Xiong Q, Sun H, Li M. Desensitization of chemical activation by auxiliary subunits: convergence of molecular determinants critical for augmenting KCNQ1 potassium channels. The Journal of Biological Chemistry. 283: 22649-58. PMID 18490447 DOI: 10.1074/Jbc.M802426200 |
0.502 |
|
| 2008 |
Gao ZB, Chen XQ, Jiang HL, Liu H, Hu GY. Electrophysiological characterization of a novel Kv channel blocker N,N'-[oxybis(2,1-ethanediyloxy-2,1-ethanediyl) ]bis(4-methyl)-benzenesulfonamide found in virtual screening. Acta Pharmacologica Sinica. 29: 405-12. PMID 18358085 DOI: 10.1111/J.1745-7254.2008.00777.X |
0.625 |
|
| 2008 |
Xiong Q, Gao Z, Wang W, Li M. Activation of Kv7 (KCNQ) voltage-gated potassium channels by synthetic compounds. Trends in Pharmacological Sciences. 29: 99-107. PMID 18206251 DOI: 10.1016/J.Tips.2007.11.010 |
0.526 |
|
| 2008 |
Yang SP, Gao ZB, Wu Y, Hu GY, Yue JM. Chlorahololides C-F: a new class of potent and selective potassium channel blockers from Chloranthus holostegius Tetrahedron. 64: 2027-2034. DOI: 10.1016/j.tet.2007.12.057 |
0.507 |
|
| 2007 |
Yang SP, Gao ZB, Wang FD, Liao SG, Chen HD, Zhang CR, Hu GY, Yue JM. Chlorahololides A and B, two potent and selective blockers of the potassium channel isolated from Chloranthus holostegius. Organic Letters. 9: 903-6. PMID 17263543 DOI: 10.1021/ol0700759 |
0.48 |
|
| 2007 |
Liu H, Gao ZB, Yao Z, Zheng S, Li Y, Zhu W, Tan X, Luo X, Shen J, Chen K, Hu GY, Jiang H. Discovering potassium channel blockers from synthetic compound database by using structure-based virtual screening in conjunction with electrophysiological assay. Journal of Medicinal Chemistry. 50: 83-93. PMID 17201412 DOI: 10.1021/Jm060414O |
0.62 |
|
| 2006 |
Gao ZB, Chen XQ, Hu GY. Inhibition of excitatory synaptic transmission by trans-resveratrol in rat hippocampus. Brain Research. 1111: 41-7. PMID 16876771 DOI: 10.1016/J.Brainres.2006.06.096 |
0.486 |
|
| 2005 |
Gao ZB, Hu GY. Trans-resveratrol, a red wine ingredient, inhibits voltage-activated potassium currents in rat hippocampal neurons. Brain Research. 1056: 68-75. PMID 16112093 DOI: 10.1016/j.brainres.2005.07.013 |
0.52 |
|
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