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Jacek Skowronski - Publications

Affiliations: 
Stony Brook University, Stony Brook, NY, United States 
Area:
Molecular Biology, Microbiology Biology
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40 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Yan J, Shun MC, Zhang Y, Hao C, Skowronski J. HIV-1 Vpr counteracts HLTF-mediated restriction of HIV-1 infection in T cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 31019079 DOI: 10.1073/pnas.1818401116  0.314
2014 Ji X, Wu Y, Yan J, Mehrens J, DeLucia M, Hao C, Gronenborn A, Skowronski J, Anh J, Xiong Y. Kill HIV by Starvation–Mechanism of Allosteric Activation of SAMHD1 Acta Crystallographica Section a Foundations and Advances. 70: C121-C121. DOI: 10.1107/S2053273314098787  0.429
2013 Fregoso OI, Ahn J, Wang C, Mehrens J, Skowronski J, Emerman M. Evolutionary toggling of Vpx/Vpr specificity results in divergent recognition of the restriction factor SAMHD1. Plos Pathogens. 9: e1003496. PMID 23874202 DOI: 10.1371/Journal.Ppat.1003496  0.344
2013 Yan J, Kaur S, DeLucia M, Hao C, Mehrens J, Wang C, Golczak M, Palczewski K, Gronenborn AM, Ahn J, Skowronski J. Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection. The Journal of Biological Chemistry. 288: 10406-17. PMID 23426366 DOI: 10.1074/Jbc.M112.443796  0.326
2012 Ahn J, Hao C, Yan J, DeLucia M, Mehrens J, Wang C, Gronenborn AM, Skowronski J. HIV/Simian Immunodeficiency Virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4 DCAF1 Journal of Biological Chemistry. 287: 12550-12558. PMID 22362772 DOI: 10.1074/Jbc.M112.340711  0.46
2011 Hrecka K, Hao C, Gierszewska M, Swanson SK, Kesik-Brodacka M, Srivastava S, Florens L, Washburn MP, Skowronski J. Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein Nature. 474: 658-661. PMID 21720370 DOI: 10.1038/Nature10195  0.34
2008 Srivastava S, Swanson SK, Manel N, Florens L, Washburn MP, Skowronski J. Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection. Plos Pathogens. 4: e1000059. PMID 18464893 DOI: 10.1371/Journal.Ppat.1000059  0.345
2008 Kwofie MA, Skowronski J. Specific recognition of Rac2 and Cdc42 by DOCK2 and DOCK9 guanine nucleotide exchange factors. The Journal of Biological Chemistry. 283: 3088-96. PMID 18056264 DOI: 10.1074/Jbc.M705170200  0.618
2006 Brenner M, Münch J, Schindler M, Wildum S, Stolte N, Stahl-Hennig C, Fuchs D, Mätz-Rensing K, Franz M, Heeney J, Ten Haaft P, Swigut T, Hrecka K, Skowronski J, Kirchhoff F. Importance of the N-distal AP-2 binding element in Nef for simian immunodeficiency virus replication and pathogenicity in rhesus macaques. Journal of Virology. 80: 4469-81. PMID 16611907 DOI: 10.1128/Jvi.80.9.4469-4481.2006  0.482
2005 Hrecka K, Swigut T, Schindler M, Kirchhoff F, Skowronski J. Nef proteins from diverse groups of primate lentiviruses downmodulate CXCR4 to inhibit migration to the chemokine stromal derived factor 1. Journal of Virology. 79: 10650-9. PMID 16051857 DOI: 10.1128/Jvi.79.16.10650-10659.2005  0.537
2005 Hill BT, Skowronski J. Human N-myristoyltransferases form stable complexes with lentiviral nef and other viral and cellular substrate proteins. Journal of Virology. 79: 1133-41. PMID 15613341 DOI: 10.1128/Jvi.79.2.1133-1141.2005  0.42
2004 Swigut T, Alexander L, Morgan J, Lifson J, Mansfield KG, Lang S, Johnson RP, Skowronski J, Desrosiers R. Impact of Nef-mediated downregulation of major histocompatibility complex class I on immune response to simian immunodeficiency virus. Journal of Virology. 78: 13335-44. PMID 15542684 DOI: 10.1128/Jvi.78.23.13335-13344.2004  0.506
2004 Schindler M, Münch J, Brenner M, Stahl-Hennig C, Skowronski J, Kirchhoff F. Comprehensive analysis of nef functions selected in simian immunodeficiency virus-infected macaques. Journal of Virology. 78: 10588-97. PMID 15367626 DOI: 10.1128/Jvi.78.19.10588-10597.2004  0.481
2004 Janardhan A, Swigut T, Hill B, Myers MP, Skowronski J. HIV-1 Nef binds the DOCK2-ELMO1 complex to activate rac and inhibit lymphocyte chemotaxis. Plos Biology. 2: E6. PMID 14737186 DOI: 10.1371/Journal.Pbio.0020006  0.689
2003 Swigut T, Greenberg M, Skowronski J. Cooperative interactions of simian immunodeficiency virus Nef, AP-2, and CD3-zeta mediate the selective induction of T-cell receptor-CD3 endocytosis. Journal of Virology. 77: 8116-26. PMID 12829850 DOI: 10.1128/Jvi.77.14.8116-8126.2003  0.457
2002 Münch J, Janardhan A, Stolte N, Stahl-Hennig C, Ten Haaft P, Heeney JL, Swigut T, Kirchhoff F, Skowronski J. T-cell receptor:CD3 down-regulation is a selected in vivo function of simian immunodeficiency virus Nef but is not sufficient for effective viral replication in rhesus macaques. Journal of Virology. 76: 12360-4. PMID 12414978 DOI: 10.1128/Jvi.76.23.12360-12364.2002  0.697
2001 Swigut T, Shohdy N, Skowronski J. Mechanism for down-regulation of CD28 by Nef Embo Journal. 20: 1593-1604. PMID 11285224 DOI: 10.1093/Emboj/20.7.1593  0.469
2001 Carl S, Greenough TC, Krumbiegel M, Greenberg M, Skowronski J, Sullivan JL, Kirchhoff F. Modulation of different human immunodeficiency virus type 1 Nef functions during progression to AIDS. Journal of Virology. 75: 3657-65. PMID 11264355 DOI: 10.1128/Jvi.75.8.3657-3665.2001  0.44
2000 Iafrate AJ, Carl S, Bronson S, Stahl-Hennig C, Swigut T, Skowronski J, Kirchhoff F. Disrupting surfaces of nef required for downregulation of CD4 and for enhancement of virion infectivity attenuates simian immunodeficiency virus replication in vivo. Journal of Virology. 74: 9836-44. PMID 11024110 DOI: 10.1128/Jvi.74.21.9836-9844.2000  0.515
2000 Swigut T, Iafrate AJ, Muench J, Kirchhoff F, Skowronski J. Simian and human immunodeficiency virus Nef proteins use different surfaces to downregulate class I major histocompatibility complex antigen expression. Journal of Virology. 74: 5691-701. PMID 10823877 DOI: 10.1128/Jvi.74.12.5691-5701.2000  0.512
2000 Carl S, Iafrate AJ, Lang SM, Stolte N, Stahl-Hennig C, Mätz-Rensing K, Fuchs D, Skowronski J, Kirchhoff F. Simian immunodeficiency virus containing mutations in N-terminal tyrosine residues and in the PxxP motif in Nef replicates efficiently in rhesus macaques. Journal of Virology. 74: 4155-64. PMID 10756028 DOI: 10.1128/Jvi.74.9.4155-4164.2000  0.446
2000 Carl S, Daniels R, Iafrate AJ, Easterbrook P, Greenough TC, Skowronski J, Kirchhoff F. Partial "repair" of defective NEF genes in a long-term nonprogressor with human immunodeficiency virus type 1 infection. The Journal of Infectious Diseases. 181: 132-40. PMID 10608759 DOI: 10.1086/315187  0.375
2000 Iafrate AJ, Carl S, Bronson S, Stahl-Hennig C, Swigut T, Skowronski J, Kirchhoff F. Disrupting Surfaces of Nef Required for Downregulation of CD4 and for Enhancement of Virion Infectivity Attenuates Simian Immunodeficiency Virus Replication In Vivo Journal of Virology. 74: 12002-12002. DOI: 10.1128/Jvi.74.24.12002-12002.2000  0.452
1999 Skowronski J, Greenberg ME, Lock M, Mariani R, Salghetti S, Swigut T, Iafrate AJ. HIV and SIV Nef modulate signal transduction and protein sorting in T cells. Cold Spring Harbor Symposia On Quantitative Biology. 64: 453-63. PMID 11232322 DOI: 10.1101/Sqb.1999.64.453  0.51
1999 Kirchhoff F, Münch J, Carl S, Stolte N, Mätz-Rensing K, Fuchs D, Haaft PT, Heeney JL, Swigut T, Skowronski J, Stahl-Hennig C. The human immunodeficiency virus type 1 nef gene can to a large extent replace simian immunodeficiency virus nef in vivo. Journal of Virology. 73: 8371-83. PMID 10482588 DOI: 10.1128/Jvi.73.10.8371-8383.1999  0.43
1999 Lock M, Greenberg ME, Iafrate AJ, Swigut T, Muench J, Kirchhoff F, Shohdy N, Skowronski J. Two elements target SIV Nef to the AP-2 clathrin adaptor complex, but only one is required for the induction of CD4 endocytosis. The Embo Journal. 18: 2722-33. PMID 10329619 DOI: 10.1093/Emboj/18.10.2722  0.491
1999 Carl S, Iafrate AJ, Lang SM, Stahl-Hennig C, Kuhn EM, Fuchs D, Mätz-Rensing K, ten Haaft P, Heeney JL, Skowronski J, Kirchhoff F. The acidic region and conserved putative protein kinase C phosphorylation site in Nef are important for SIV replication in rhesus macaques. Virology. 257: 138-55. PMID 10208928 DOI: 10.1006/Viro.1999.9645  0.492
1999 Carl S, Iafrate AJ, Skowronski J, Stahl-Hennig C, Kirchhoff F. Effect of the attenuating deletion and of sequence alterations evolving in vivo on simian immunodeficiency virus C8-Nef function. Journal of Virology. 73: 2790-7. PMID 10074126 DOI: 10.1128/Jvi.73.4.2790-2797.1999  0.474
1999 Carl S, Iafrate AJ, Skowronski J, Stahl-Hennig C, Kirchhoff F. Effect of the Attenuating Deletion and of Sequence Alterations Evolving In Vivo on Simian Immunodeficiency Virus C8-Nef Function Journal of Virology. 73: 2790-2797. DOI: 10.1128/jvi.73.4.2790-2797.1999  0.383
1998 Greenberg M, DeTulleo L, Rapoport I, Skowronski J, Kirchhausen T. A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4. Current Biology : Cb. 8: 1239-42. PMID 9811611 DOI: 10.1016/S0960-9822(07)00518-0  0.509
1998 Greenberg ME, Iafrate AJ, Skowronski J. The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes. The Embo Journal. 17: 2777-89. PMID 9582271 DOI: 10.1093/Emboj/17.10.2777  0.457
1997 Greenberg ME, Bronson S, Lock M, Neumann M, Pavlakis GN, Skowronski J. Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation. The Embo Journal. 16: 6964-76. PMID 9384576 DOI: 10.1093/Emboj/16.23.6964  0.476
1997 Iafrate AJ, Bronson S, Skowronski J. Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling Embo Journal. 16: 673-684. PMID 9049297 DOI: 10.1093/Emboj/16.4.673  0.505
1996 Mariani R, Kirchhoff F, Greenough TC, Sullivan JL, Desrosiers RC, Skowronski J. High frequency of defective nef alleles in a long-term survivor with nonprogressive human immunodeficiency virus type 1 infection. Journal of Virology. 70: 7752-64. PMID 8892896 DOI: 10.1128/Jvi.70.11.7752-7764.1996  0.46
1995 Salghetti S, Mariani R, Skowronski J. Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail. Proceedings of the National Academy of Sciences of the United States of America. 92: 349-53. PMID 7831289 DOI: 10.1073/Pnas.92.2.349  0.443
1993 Mariani R, Skowronski J. CD4 down-regulation by nef alleles isolated from human immunodeficiency virus type 1-infected individuals Proceedings of the National Academy of Sciences of the United States of America. 90: 5549-5553. PMID 8516299 DOI: 10.1073/Pnas.90.12.5549  0.497
1993 Skowronski J, Parks D, Mariani R. Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene. The Embo Journal. 12: 703-713. DOI: 10.1002/J.1460-2075.1993.Tb05704.X  0.519
1991 Skowronski J. Expression of a human immunodeficiency virus type 1 long terminal repeat/simian virus 40 early region fusion gene in transgenic mice Journal of Virology. 65: 754-762. PMID 1846196 DOI: 10.1128/Jvi.65.2.754-762.1991  0.399
1990 Skowronski J, Jolicoeur C, Alpert S, Hanahan D. Determinants of the B-cell response against a transgenic autoantigen. Proceedings of the National Academy of Sciences of the United States of America. 87: 7487-91. PMID 2217180 DOI: 10.1073/Pnas.87.19.7487  0.374
1989 Mbikay M, Grant SG, Sirois F, Tadros H, Skowronski J, Lazure C, Seidah NG, Hanahan D, Chrétien M. cDNA sequence of neuroendocrine protein 7B2 expressed in beta cell tumors of transgenic mice. International Journal of Peptide and Protein Research. 33: 39-45. PMID 2542174 DOI: 10.1111/J.1399-3011.1989.Tb00681.X  0.329
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