Howard C. Towle - Publications

Affiliations: 
University of Minnesota, Twin Cities, Minneapolis, MN 
Area:
Molecular Biology, Biochemistry

81 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2013 Chambers KT, Chen Z, Lai L, Leone TC, Towle HC, Kralli A, Crawford PA, Finck BN. PGC-1β and ChREBP partner to cooperatively regulate hepatic lipogenesis in a glucose concentration-dependent manner. Molecular Metabolism. 2: 194-204. PMID 24049734 DOI: 10.1016/J.Molmet.2013.05.001  0.459
2013 Petrie JL, Al-Oanzi ZH, Arden C, Tudhope SJ, Mann J, Kieswich J, Yaqoob MM, Towle HC, Agius L. Glucose induces protein targeting to glycogen in hepatocytes by fructose 2,6-bisphosphate-mediated recruitment of MondoA to the promoter. Molecular and Cellular Biology. 33: 725-38. PMID 23207906 DOI: 10.1128/Mcb.01576-12  0.656
2012 Hanse EA, Mashek DG, Becker JR, Solmonson AD, Mullany LK, Mashek MT, Towle HC, Chau AT, Albrecht JH. Cyclin D1 inhibits hepatic lipogenesis via repression of carbohydrate response element binding protein and hepatocyte nuclear factor 4α. Cell Cycle (Georgetown, Tex.). 11: 2681-90. PMID 22751438 DOI: 10.4161/Cc.21019  0.461
2012 Arden C, Tudhope SJ, Petrie JL, Al-Oanzi ZH, Cullen KS, Lange AJ, Towle HC, Agius L. Fructose 2,6-bisphosphate is essential for glucose-regulated gene transcription of glucose-6-phosphatase and other ChREBP target genes in hepatocytes. The Biochemical Journal. 443: 111-23. PMID 22214556 DOI: 10.1042/Bj20111280  0.643
2011 Arden C, Petrie JL, Tudhope SJ, Al-Oanzi Z, Claydon AJ, Beynon RJ, Towle HC, Agius L. Elevated glucose represses liver glucokinase and induces its regulatory protein to safeguard hepatic phosphate homeostasis. Diabetes. 60: 3110-20. PMID 22013014 DOI: 10.2337/Db11-0061  0.601
2011 Pashkov V, Huang J, Parameswara VK, Kedzierski W, Kurrasch DM, Tall GG, Esser V, Gerard RD, Uyeda K, Towle HC, Wilkie TM. Regulator of G protein signaling (Rgs16) inhibits hepatic fatty acid oxidation in a carbohydrate response element-binding protein (ChREBP)-dependent manner Journal of Biological Chemistry. 286: 15116-15125. PMID 21357625 DOI: 10.1074/Jbc.M110.216234  0.5
2010 Davies MN, O'Callaghan BL, Towle HC. Activation and repression of glucose-stimulated ChREBP requires the concerted action of multiple domains within the MondoA conserved region. American Journal of Physiology. Endocrinology and Metabolism. 299: E665-74. PMID 20682844 DOI: 10.1152/Ajpendo.00349.2010  0.683
2010 Aipoalani DL, O'Callaghan BL, Mashek DG, Mariash CN, Towle HC. Overlapping roles of the glucose-responsive genes, S14 and S14R, in hepatic lipogenesis. Endocrinology. 151: 2071-7. PMID 20233797 DOI: 10.1210/En.2009-1058  0.528
2008 Davies MN, O'Callaghan BL, Towle HC. Glucose activates ChREBP by increasing its rate of nuclear entry and relieving repression of its transcriptional activity. The Journal of Biological Chemistry. 283: 24029-38. PMID 18591247 DOI: 10.1074/Jbc.M801539200  0.715
2008 Tsatsos NG, Augustin LB, Anderson GW, Towle HC, Mariash CN. Hepatic expression of the SPOT 14 (S14) paralog S14-related (Mid1 interacting protein) is regulated by dietary carbohydrate. Endocrinology. 149: 5155-61. PMID 18556348 DOI: 10.1210/En.2008-0215  0.766
2008 Tsatsos NG, Davies MN, O'Callaghan BL, Towle HC. Identification and function of phosphorylation in the glucose-regulated transcription factor ChREBP. The Biochemical Journal. 411: 261-70. PMID 18215143 DOI: 10.1042/Bj20071156  0.783
2007 Towle HC. The metabolic sensor GCN2 branches out. Cell Metabolism. 5: 85-7. PMID 17276350 DOI: 10.1016/J.Cmet.2007.01.010  0.316
2007 Ma L, Sham YY, Walters KJ, Towle HC. A critical role for the loop region of the basic helix-loop-helix/leucine zipper protein Mlx in DNA binding and glucose-regulated transcription. Nucleic Acids Research. 35: 35-44. PMID 17148476 DOI: 10.1093/Nar/Gkl987  0.496
2006 Ma L, Robinson LN, Towle HC. ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver. The Journal of Biological Chemistry. 281: 28721-30. PMID 16885160 DOI: 10.1074/Jbc.M601576200  0.624
2006 Tsatsos NG, Towle HC. Glucose activation of ChREBP in hepatocytes occurs via a two-step mechanism. Biochemical and Biophysical Research Communications. 340: 449-56. PMID 16375857 DOI: 10.1016/J.Bbrc.2005.12.029  0.793
2005 Towle HC. Glucose as a regulator of eukaryotic gene transcription. Trends in Endocrinology and Metabolism: Tem. 16: 489-94. PMID 16269245 DOI: 10.1016/J.Tem.2005.10.003  0.591
2005 Ma L, Tsatsos NG, Towle HC. Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes. The Journal of Biological Chemistry. 280: 12019-27. PMID 15664996 DOI: 10.1074/Jbc.M413063200  0.804
2004 Stoeckman AK, Ma L, Towle HC. Mlx is the functional heteromeric partner of the carbohydrate response element-binding protein in glucose regulation of lipogenic enzyme genes. The Journal of Biological Chemistry. 279: 15662-9. PMID 14742444 DOI: 10.1074/Jbc.M311301200  0.836
2004 Wu C, Okar DA, Stoeckman AK, Peng LJ, Herrera AH, Herrera JE, Towle HC, Lange AJ. A potential role for fructose-2,6-bisphosphate in the stimulation of hepatic glucokinase gene expression. Endocrinology. 145: 650-8. PMID 14617577 DOI: 10.1210/En.2003-1290  0.783
2002 Stoeckman AK, Towle HC. The role of SREBP-1c in nutritional regulation of lipogenic enzyme gene expression. The Journal of Biological Chemistry. 277: 27029-35. PMID 12016216 DOI: 10.1074/Jbc.M202638200  0.817
2001 Towle HC. Glucose and cAMP: Adversaries in the regulation of hepatic gene expression Proceedings of the National Academy of Sciences of the United States of America. 98: 13476-13478. PMID 11717416 DOI: 10.1073/Pnas.251530798  0.447
2001 Armstrong MB, Towle HC. Polyunsaturated fatty acids stimulate hepatic UCP-2 expression via a PPARα-mediated pathway American Journal of Physiology - Endocrinology and Metabolism. 281. PMID 11701434 DOI: 10.1152/Ajpendo.2001.281.6.E1197  0.357
2001 O'Callaghan BL, Koo SH, Wu Y, Freake HC, Towle HC. Glucose regulation of the acetyl-CoA carboxylase promoter PI in rat hepatocytes. The Journal of Biological Chemistry. 276: 16033-9. PMID 11340083 DOI: 10.1074/Jbc.M101557200  0.779
2001 Rufo C, Teran-Garcia M, Nakamura MT, Koo SH, Towle HC, Clarke SD. Involvement of a unique carbohydrate-responsive factor in the glucose regulation of rat liver fatty-acid synthase gene transcription. The Journal of Biological Chemistry. 276: 21969-75. PMID 11279238 DOI: 10.1074/Jbc.M100461200  0.719
2001 Koo SH, Dutcher AK, Towle HC. Glucose and insulin function through two distinct transcription factors to stimulate expression of lipogenic enzyme genes in liver. The Journal of Biological Chemistry. 276: 9437-45. PMID 11112788 DOI: 10.1074/Jbc.M010029200  0.751
2001 Towle HC. Chapter 10 Nutritional regulation of hepatic gene expression Cell and Molecular Response to Stress. 2: 129-143. DOI: 10.1016/S1568-1254(01)80012-7  0.309
2000 Bergad PL, Schwarzenberg SJ, Humbert JT, Morrison M, Amarasinghe S, Towle HC, Berry SA. Inhibition of growth hormone action in models of inflammation American Journal of Physiology - Cell Physiology. 279. PMID 11078706 DOI: 10.1152/Ajpcell.2000.279.6.C1906  0.386
2000 Kaytor EN, Qian J, Towle HC, Olson LK. An indirect role for upstream stimulatory factor in glucose-mediated induction of pyruvate kinase and S14 gene expression. Molecular and Cellular Biochemistry. 210: 13-21. PMID 10976753 DOI: 10.1023/A:1007006429041  0.633
2000 Bergad PL, Towle HC, Berry SA. Yin-yang 1 and glucocorticoid receptor participate in the Stat5-mediated growth hormone response of the serine protease inhibitor 2.1 gene Journal of Biological Chemistry. 275: 8114-8120. PMID 10713133 DOI: 10.1074/Jbc.275.11.8114  0.411
2000 Koo SH, Towle HC. Glucose regulation of mouse S(14) gene expression in hepatocytes. Involvement of a novel transcription factor complex. The Journal of Biological Chemistry. 275: 5200-7. PMID 10671567 DOI: 10.1074/Jbc.275.7.5200  0.758
2000 Magaña MM, Koo SH, Towle HC, Osborne TF. Different sterol regulatory element-binding protein-1 isoforms utilize distinct co-regulatory factors to activate the promoter for fatty acid synthase. The Journal of Biological Chemistry. 275: 4726-33. PMID 10671504 DOI: 10.1074/Jbc.275.7.4726  0.652
1999 Wendt CH, Sharma R, Towle H, Gick G, Ingbar DH. Hyperoxia upregulated Na,K-adenosine triphosphatase beta1 gene transcription. Chest. 116: 87S-88S. PMID 10424606 DOI: 10.1378/Chest.116.Suppl_1.87S  0.304
1999 Bergad PL, Towle HC, Berry SA. Definition of a high affinity growth hormone DNA response element Molecular and Cellular Endocrinology. 150: 151-159. PMID 10411309 DOI: 10.1016/S0303-7207(99)00012-X  0.369
1999 Qian J, Kaytor EN, Towle HC, Olson LK. Upstream stimulatory factor regulates Pdx-1 gene expression in differentiated pancreatic β-cells Biochemical Journal. 341: 315-322. PMID 10393088 DOI: 10.1042/0264-6021:3410315  0.483
1999 Berry SA, Bergad PL, Stolz AM, Towle HC, Schwarzenberg SJ. Regulation of Spi 2.1 and 2.2 gene expression after turpentine inflammation: Discordant responses to IL-6 American Journal of Physiology - Cell Physiology. 276. PMID 10362600 DOI: 10.1152/Ajpcell.1999.276.6.C1374  0.432
1999 Berry SA, Bergad PL, Schwarzenberg SJ, Amarasinghe S, Towle HC. Modulation of the Growth Hormone Response of the Serine Protease Inhibitor 2.1 Gene by Cytokines in Rat Hepatocytes Pediatric Research. 45: 85A-85A. DOI: 10.1203/00006450-199904020-00505  0.333
1998 Wendt CH, Towle H, Sharma R, Duvick S, Kawakami K, Gick G, Ingbar DH. Regulation of Na-K-ATPase gene expression by hyperoxia in MDCK cells. American Journal of Physiology. Cell Physiology. 274: C356-C364. PMID 29590919 DOI: 10.1152/Ajpcell.1998.274.2.C356  0.349
1998 Wendt CH, Sharma R, Bair R, Towle H, Ingbar DH. Oxidant effects on epithelial Na,K-ATPase gene expression and promoter function. Environmental Health Perspectives. 106: 1213-7. PMID 9788900 DOI: 10.1289/Ehp.98106S51213  0.367
1998 Amersinghe S, Berry SA, Towle H, Schwarzenberg SJ. An in Vitro Model of Divergent Gene Regulation in the Acute Phase Response (Apr) † 556 Pediatric Research. 43: 97-97. DOI: 10.1203/00006450-199804001-00577  0.449
1997 Wilkinson JR, Towle HC. Identification and characterization of the AF-1 transactivation domain of thyroid hormone receptor β1 Journal of Biological Chemistry. 272: 23824-23832. PMID 9295330 DOI: 10.1074/Jbc.272.38.23824  0.331
1997 Towle HC, Kaytor EN, Shih HM. Regulation of the expression of lipogenic enzyme genes by carbohydrate Annual Review of Nutrition. 17: 405-433. PMID 9240934 DOI: 10.1146/Annurev.Nutr.17.1.405  0.568
1997 Kaytor EN, Shih HM, Towle HC. Carbohydrate regulation of hepatic gene expression: Evidence against a role for the upstream stimulatory factor Journal of Biological Chemistry. 272: 7525-7531. PMID 9054457 DOI: 10.1074/Jbc.272.11.7525  0.525
1996 Towle HC, Kaytor EN, Shih HM. Metabolic regulation of hepatic gene expression Biochemical Society Transactions. 24: 364-368. PMID 8736764 DOI: 10.1042/Bst0240364  0.435
1995 Uppaluri R, Towle HC. Genetic dissection of thyroid hormone receptor β: Identification of mutations that separate hormone binding and transcriptional activation Molecular and Cellular Biology. 15: 1499-1512. PMID 7862143 DOI: 10.1128/Mcb.15.3.1499  0.373
1995 Liu Z, Towle HC. Functional synergism in the carbohydrate-induced activation of liver-type pyruvate kinase gene expression. The Biochemical Journal. 105-11. PMID 7755551 DOI: 10.1042/Bj3080105  0.577
1995 Kim JB, Spotts GD, Halvorsen YD, Shih HM, Ellenberger T, Towle HC, Spiegelman BM. Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain Molecular and Cellular Biology. 15: 2582-2588. PMID 7739539 DOI: 10.1128/Mcb.15.5.2582  0.356
1995 Shih HM, Liu Z, Towle HC. Two CACGTG motifs with proper spacing dictate the carbohydrate regulation of hepatic gene transcription Journal of Biological Chemistry. 270: 21991-21997. PMID 7665621 DOI: 10.1074/Jbc.270.37.21991  0.601
1995 Olson LK, Sharma A, Peshavaria M, Wright CVE, Towle HC, Robertson RP, Stein R. Reduction of insulin gene transcription in HIT-T15 β cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression Proceedings of the National Academy of Sciences of the United States of America. 92: 9127-9131. PMID 7568086 DOI: 10.1073/Pnas.92.20.9127  0.548
1995 Bergad PL, Shih HM, Towle HC, Schwarzenberg SJ, Berry SA. Growth hormone induction of hepatic serine protease inhibitor 2.1 Transcription is mediated by a Stat5-related factor binding synergistically to two γ-activated sites Journal of Biological Chemistry. 270: 24903-24910. PMID 7559615 DOI: 10.1074/Jbc.270.42.24903  0.404
1995 Towle HC. Metabolic regulation of gene transcription in mammals Journal of Biological Chemistry. 270: 23235-23238. PMID 7559472 DOI: 10.1074/Jbc.270.40.23235  0.43
1994 Shih HM, Towle HC. Definition of the carbohydrate response element of the rat s14 gene: Context of the CACGTG motif determines the specificity of carbohydrate regulation Journal of Biological Chemistry. 269: 9380-9387. PMID 8132677  0.524
1994 Liu HC, Towle HC. Functional synergism between multiple thyroid hormone response elements regulates hepatic expression of the rat S14 gene Molecular Endocrinology. 8: 1021-1037. PMID 7997231 DOI: 10.1210/Mend.8.8.7997231  0.463
1994 Redmon JB, Towle HC, Robertson RP. Regulation of human insulin gene transcription by glucose, epinephrine, and somatostatin Diabetes. 43: 546-551. PMID 7907998 DOI: 10.2337/Diab.43.4.546  0.505
1994 Liimatta M, Towle HC, Clarke S, Jump DB. Dietary polyunsaturated fatty acids interfere with the insulin/glucose activation of L-type pyruvate kinase gene transcription Molecular Endocrinology. 8: 1147-1153. PMID 7838147 DOI: 10.1210/Mend.8.9.7838147  0.472
1994 Berry SA, Bergad PL, Whaley CR, Towle HC. Binding of a growth hormone-inducible nuclear factor is mediated by tyrosine phosphorylation Molecular Endocrinology. 8: 1714-1719. PMID 7535894 DOI: 10.1210/Mend.8.12.7535894  0.435
1993 Liu Z, Thompson KS, Towle HC. Carbohydrate regulation of the rat L-type pyruvate kinase gene requires two nuclear factors: LF-A1 and a member of the c-myc family. The Journal of Biological Chemistry. 268: 12787-95. PMID 8509413  0.461
1993 Olson LK, Redmon JB, Towle HC, Robertson RP. Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein Journal of Clinical Investigation. 92: 514-519. PMID 8326016 DOI: 10.1172/Jci116596  0.563
1992 Shih HM, Towle HC. Definition of the carbohydrate response element of the rat S14 gene: Evidence for a common factor required for carbohydrate regulation of hepatic genes Journal of Biological Chemistry. 267: 13222-13228. PMID 1618827  0.423
1991 Thompson KS, Towle HC. Localization of the carbohydrate response element of the rat L-type pyruvate kinase gene. The Journal of Biological Chemistry. 266: 8679-82. PMID 2026584  0.387
1991 MacDonald MJ, McKenzie DI, Kaysen JH, Walker TM, Moran SM, Fahien LA, Towle HC. Glucose regulates leucine-induced insulin release and the expression of the branched chain ketoacid dehydrogenase E1 alpha subunit gene in pancreatic islets. The Journal of Biological Chemistry. 266: 1335-40. PMID 1985951  0.448
1990 Yoon JB, Berry SA, Seelig S, Towle HC. An inducible nuclear factor binds to a growth hormone-regulated gene Journal of Biological Chemistry. 265: 19947-19954. PMID 2246271  0.373
1990 Zilz ND, Murray MB, Towle HC. Identification of multiple thyroid hormone response elements located far upstream from the rat S14 promoter Journal of Biological Chemistry. 265: 8136-8143. PMID 2159469  0.367
1989 Jacoby DB, Zilz ND, Towle HC. Sequences within the 5'-flanking region of the S14 gene confer responsiveness to glucose in primary hepatocytes Journal of Biological Chemistry. 264: 17623-17626. PMID 2808335  0.509
1989 Murray M, Towle HC. Identification of nuclear factors that enhance binding of the thyroid hormone receptor to a thyroid hormone response element Molecular Endocrinology. 3: 1434-1442. PMID 2608066 DOI: 10.1210/Mend-3-9-1434  0.323
1988 Mazuski JE, Platt JL, West MA, Simmons RL, Towle HC, Cerra FB. Direct Effects of Endotoxin on Hepatocytes: Synthesis of a Specific Secretory Protein Archives of Surgery. 123: 340-344. PMID 3341913 DOI: 10.1001/Archsurg.1988.01400270074011  0.351
1986 Kinlaw WB, Schwartz HL, Towle HC, Oppenheimer JH. Opposing effects of glucagon and triiodothyronine on the hepatic levels of messenger ribonucleic acid S14 and the dependence of such effects on circadian factors Journal of Clinical Investigation. 78: 1091-1096. PMID 3760185 DOI: 10.1172/Jci112665  0.357
1986 Jump DB, Tao TY, Towle HC, Oppenheimer JH. Dissociation of hepatic messenger ribonucleic acid(S14) levels and nuclear transcriptional rates in suckling rats Endocrinology. 118: 1892-1896. PMID 3754508 DOI: 10.1210/Endo-118-5-1892  0.409
1986 Towle HC, Mariash CN. Regulation of hepatic gene expression by lipogenic diet and thyroid hormone Federation Proceedings. 45: 2406-2411. PMID 3525234  0.305
1986 Tao TY, Towle HC. Coordinate regulation of rat liver genes by thyroid hormone and dietary carbohydrate Annals of the New York Academy of Sciences. 20-30. PMID 3467640 DOI: 10.1111/J.1749-6632.1986.Tb15518.X  0.376
1985 Narayan P, Towle HC. Stabilization of a specific nuclear mrna precursor by thyroid hormone Molecular and Cellular Biology. 5: 2642-2646. PMID 3837180 DOI: 10.1128/Mcb.5.10.2642  0.396
1983 Liaw C, Seelig S, Mariash CN, Oppenheimer JH, Towle HC. Interactions of thyroid hormone, growth hormone, and high carbohydrate, fat-free diet in regulating several rat liver messenger ribonucleic acid species Biochemistry. 22: 213-221. PMID 6187358 DOI: 10.1021/Bi00270A031  0.326
1982 Seelig S, Jump DB, Towle HC, Liaw C, Mariash CN, Schwartz HL, Oppenheimer JH. Paradoxical effects of cycloheximide on the ultra-rapid induction of two hepatic mRNA sequences by triiodothyronine (T3) Endocrinology. 110: 671-673. PMID 6276146 DOI: 10.1210/Endo-110-2-671  0.3
1982 Miksicek RJ, Towle HC. Changes in the rates of synthesis and messenger RNA levels of hepatic glucose-6-phosphate and 6-phosphogluconate dehydrogenases following induction by diet or thyroid hormone Journal of Biological Chemistry. 257: 11829-11835. PMID 6181061  0.337
1981 Oppenheimer JH, Mariash CN, Towle HC, Schwartz HL, Kaiser FE. Interaction of T3 and carbohydrate in the induction of lipogenic enzymes Life Sciences. 28: 1693-1699. PMID 7242255 DOI: 10.1016/0024-3205(81)90340-4  0.431
1981 Forciea MA, Schwartz HL, Towle HC, Mariash CN, Kaiser FE, Oppenheimer JH. Thyroid hormone-carbohydrate interaction in the rat. Correlation between age-related reductions in the inducibility of hepatic malic enzyme by triiodo-L-thyronine and a high carbohydrate, fat-free diet Journal of Clinical Investigation. 67: 1739-1747. PMID 7240417 DOI: 10.1172/Jci110212  0.356
1981 Towle HC, Mariash CN, Schwartz HL, Oppenheimer JH. Quantitation of rat liver messenger ribonucleic acid for malic enzyme during induction by thyroid hormone Biochemistry. 20: 3486-3492. PMID 7020754 DOI: 10.1021/Bi00515A028  0.323
1981 Seelig S, Liaw C, Towle HC, Oppenheimer JH. Thyroid hormone attenuates and augments hepatic gene expression at a pretranslational level Proceedings of the National Academy of Sciences of the United States of America. 78: 4733-4737. PMID 6946422 DOI: 10.1073/Pnas.78.8.4733  0.381
1981 Mariash CN, McSwigan CH, Towle HC, Schwartz HL, Oppenheimer JH. Glucose and triiodothyronine both induce malic enzyme in the rat hepatocyte culture. Evidence that triiodothyronine multiplies a primary glucose-generated signal Journal of Clinical Investigation. 68: 1485-1490. PMID 6274910 DOI: 10.1172/Jci110401  0.478
1980 Mariash CN, Kaiser FE, Schwartz HL, Towle HC, Oppenheimer JH. Synergism of thyroid hormone and high carbohydrate diet in the induction of lipogenic enzymes in the rat. Mechanisms and implications Journal of Clinical Investigation. 65: 1126-1134. PMID 7364940 DOI: 10.1172/Jci109766  0.365
1980 Towle HC, Mariash CN, Oppenheimer JH. Changes in the hepatic levels of messenger ribonucleic acid for malic enzyme during induction by thyroid hormone or diet Biochemistry. 19: 579-585. PMID 7356948 DOI: 10.1021/Bi00544A029  0.335
1980 Simat BM, Towle HC, Schwartz HL, Oppenheimer JH. Difference between thyroidectomized and hypophysectomized animals in their hepatic ribonucleic acid response to thyroid hormone Endocrinology. 107: 1338-1344. PMID 6159196 DOI: 10.1210/Endo-107-5-1338  0.301
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