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Randy M. Wadkins - Publications

Affiliations: 
The University of Mississippi, USA 
Area:
Biochemistry
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46 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Bhavsar-Jog YP, Van Dornshuld E, Brooks TA, Tschumper GS, Wadkins RM. Co-Localization of DNA i-Motif-Forming Sequences and 5-Hydroxymethyl-cytosines in Human Embryonic Stem Cells. Molecules (Basel, Switzerland). 24. PMID 31597270 DOI: 10.3390/Molecules24193619  0.692
2019 Molnar MM, Liddell SC, Wadkins RM. Effects of Polyamine Binding on the Stability of DNA i-Motif Structures. Acs Omega. 4: 8967-8973. PMID 31459985 DOI: 10.1021/acsomega.9b00784  0.418
2018 Morgan RK, Molnar MM, Batra H, Summerford B, Wadkins RM, Brooks TA. Effects of 5-Hydroxymethylcytosine Epigenetic Modification on the Stability and Molecular Recognition of VEGF i-Motif and G-Quadruplex Structures. Journal of Nucleic Acids. 2018: 9281286. PMID 29862069 DOI: 10.1155/2018/9281286  0.426
2017 Molnar MM, Morgan RK, Brooks TA, Wadkins RM. Effects of 5-Hydroxymethylcytosine Epigenetic Modifications within the VEGF Promoter Region on G-Quadruplex and I-Motif DNA Structure and Stability Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.409  0.468
2015 Reilly SM, Morgan RK, Brooks TA, Wadkins RM. Effect of interior loop length on the thermal stability and pK(a) of i-motif DNA. Biochemistry. 54: 1364-70. PMID 25619229 DOI: 10.1021/Bi5014722  0.665
2015 Sengupta B, Reilly SM, Davis DE, Harris K, Wadkins RM, Ward D, Gholar D, Hampton C. Excited state proton transfer of natural flavonoids and their chromophores in duplex and tetraplex DNAs. The Journal of Physical Chemistry. B. 119: 2546-56. PMID 25393681 DOI: 10.1021/Jp508599H  0.657
2015 Morgan R, Wadkins R, Brooks T. Abstract 1050: Effects of 5-hydroxymethylcytosine epigenetic modification on G-quadruplex and i-motif structure and stability within the VEGF promoter Cancer Research. 75: 1050-1050. DOI: 10.1158/1538-7445.Am2015-1050  0.395
2015 Reilly SM, Bhavsar-Jog YP, Wingate SE, Lyons DF, Wright RT, Brooks TA, Correia JJ, Jameson DM, Wadkins RM. Epigenetics and Other Factors that Affect Folding and Stability of DNA I-Motif Structures Biophysical Journal. 108: 397a. DOI: 10.1016/J.Bpj.2014.11.2174  0.702
2015 Wright RT, Reilly SM, Wadkins RM, Correia JJ. The Effects of Ionic Strength on the Hydrodynamic Properties of I-Motif Folding Biophysical Journal. 108: 394a. DOI: 10.1016/J.Bpj.2014.11.2158  0.642
2014 Reilly SM, Lyons DF, Wingate SE, Wright RT, Correia JJ, Jameson DM, Wadkins RM. Folding and hydrodynamics of a DNA i-motif from the c-MYC promoter determined by fluorescent cytidine analogs. Biophysical Journal. 107: 1703-11. PMID 25296324 DOI: 10.1016/J.Bpj.2014.08.014  0.688
2014 Stoddard SV, Hamann MT, Wadkins RM. Insights and ideas garnered from marine metabolites for development of dual-function acetylcholinesterase and amyloid-β aggregation inhibitors. Marine Drugs. 12: 2114-31. PMID 24714126 DOI: 10.3390/Md12042114  0.572
2014 Bhavsar-Jog YP, Van Dornshuld E, Brooks TA, Tschumper GS, Wadkins RM. Epigenetic modification, dehydration, and molecular crowding effects on the thermodynamics of i-motif structure formation from C-Rich DNA Biochemistry. 53: 1586-1594. PMID 24564458 DOI: 10.1021/Bi401523B  0.728
2012 Yu X, Sigler SC, Hossain D, Wierdl M, Gwaltney SR, Potter PM, Wadkins RM. Global and local molecular dynamics of a bacterial carboxylesterase provide insight into its catalytic mechanism. Journal of Molecular Modeling. 18: 2869-83. PMID 22127613 DOI: 10.1007/S00894-011-1308-9  0.588
2011 Bhavsar YP, Reilly SM, Wadkins RM. Evaluation of fluorescent analogs of deoxycytidine for monitoring DNA transitions from duplex to functional structures. Journal of Nucleic Acids. 2011: 986820. PMID 21869922 DOI: 10.4061/2011/986820  0.644
2010 Stoddard SV, Yu X, Potter PM, Wadkins RM. In Silico Design and Evaluation of Carboxylesterase Inhibitors. Journal of Pest Science. 35: 240-249. PMID 23487487 DOI: 10.1584/Jpestics.R10-06  0.663
2010 Hatfield MJ, Tsurkan L, Hyatt JL, Yu X, Edwards CC, Hicks LD, Wadkins RM, Potter PM. Biochemical and molecular analysis of carboxylesterase-mediated hydrolysis of cocaine and heroin British Journal of Pharmacology. 160: 1916-1928. PMID 20649590 DOI: 10.1111/J.1476-5381.2010.00700.X  0.497
2010 Yu X, Wierdl M, Potter P, Wadkins R. Low Frequency Motions of a Carboxylesterase and their Relation to Substrate Selectivity and Catalytic Activity Biophysical Journal. 98: 443a. DOI: 10.1016/J.Bpj.2009.12.2407  0.577
2009 Hicks LD, Hyatt JL, Stoddard S, Tsurkan L, Edwards CC, Wadkins RM, Potter PM. Improved, selective, human intestinal carboxylesterase inhibitors designed to modulate 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (irinotecan; CPT-11) toxicity Journal of Medicinal Chemistry. 52: 3742-3752. PMID 19534556 DOI: 10.1021/Jm9001296  0.572
2009 Zhang X, Wadkins RM. DNA hairpins containing the cytidine analog pyrrolo-dC: structural, thermodynamic, and spectroscopic studies. Biophysical Journal. 96: 1884-91. PMID 19254547 DOI: 10.1016/J.Bpj.2008.12.3890  0.452
2009 Harada T, Nakagawa Y, Wadkins RM, Potter PM, Wheelock CE. Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis. Bioorganic & Medicinal Chemistry. 17: 149-64. PMID 19062296 DOI: 10.1016/J.Bmc.2008.11.008  0.355
2009 Yu X, Wierdl M, Potter PM, Wadkins RM. Mobility of a Loop of a B. subtilis Carboxylesterase and its Effect on Substrate Conversion Biophysical Journal. 96: 323a. DOI: 10.1016/J.Bpj.2008.12.1620  0.591
2008 Hatfield JM, Wierdl M, Wadkins RM, Potter PM. Modifications of human carboxylesterase for improved prodrug activation. Expert Opinion On Drug Metabolism & Toxicology. 4: 1153-65. PMID 18721110 DOI: 10.1517/17425255.4.9.1153  0.329
2007 Hyatt JL, Wadkins RM, Tsurkan L, Hicks LD, Hatfield MJ, Edwards CC, Ross CR, Cantalupo SA, Crundwell G, Danks MK, Guy RK, Potter PM. Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. Journal of Medicinal Chemistry. 50: 5727-34. PMID 17941623 DOI: 10.1021/Jm0706867  0.334
2007 Hyatt JL, Moak T, Hatfield MJ, Tsurkan L, Edwards CC, Wierdl M, Danks MK, Wadkins RM, Potter PM. Selective inhibition of carboxylesterases by isatins, indole-2,3-diones Journal of Medicinal Chemistry. 50: 1876-1885. PMID 17378546 DOI: 10.1021/Jm061471K  0.355
2007 Wadkins RM, Hyatt JL, Edwards CC, Tsurkan L, Redinbo MR, Wheelock CE, Jones PD, Hammock BD, Potter PM. Analysis of mammalian carboxylesterase inhibition by trifluoromethylketone-containing compounds. Molecular Pharmacology. 71: 713-23. PMID 17167034 DOI: 10.1124/Mol.105.021683  0.351
2007 Samudrala R, Zhang X, Wadkins RM, Mattern DL. Synthesis of a non-cationic, water-soluble perylenetetracarboxylic diimide and its interactions with G-quadruplex-forming DNA Bioorganic and Medicinal Chemistry. 15: 186-193. PMID 17079147 DOI: 10.1016/J.Bmc.2006.09.075  0.45
2006 Potter PM, Wadkins RM. Carboxylesterases--detoxifying enzymes and targets for drug therapy. Current Medicinal Chemistry. 13: 1045-54. PMID 16611083 DOI: 10.2174/092986706776360969  0.325
2006 Wierdl M, Wadkins R, Redinbo M, Tsurkan L, Potter P. 655. Development of a Human Carboxylesterase That Can Efficiently Metabolize CPT-11 Molecular Therapy. 13: S252. DOI: 10.1016/J.Ymthe.2006.08.731  0.326
2005 Harel M, Hyatt JL, Brumshtein B, Morton CL, Wadkins RM, Silman I, Sussman JL, Potter PM. The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase Chemico-Biological Interactions. 157: 153-157. PMID 16289500 DOI: 10.1016/J.Cbi.2005.10.016  0.353
2005 Hyatt JL, Tsurkan L, Morton CL, Yoon KJ, Harel M, Brumshtein B, Silman I, Sussman JL, Wadkins RM, Potter PM. Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11. Chemico-Biological Interactions. 157: 247-52. PMID 16257398 DOI: 10.1016/J.Cbi.2005.10.033  0.337
2005 Hyatt JL, Stacy V, Wadkins RM, Yoon KJ, Wierdl M, Edwards CC, Zeller M, Hunter AD, Danks MK, Crundwell G, Potter PM. Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety. Journal of Medicinal Chemistry. 48: 5543-50. PMID 16107154 DOI: 10.1021/Jm0504196  0.314
2005 Wadkins RM, Hyatt JL, Wei X, Yoon KJ, Wierdl M, Edwards CC, Morton CL, Obenauer JC, Damodaran K, Beroza P, Danks MK, Potter PM. Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. Journal of Medicinal Chemistry. 48: 2906-15. PMID 15828829 DOI: 10.1021/Jm049011J  0.349
2005 Harel M, Hyatt JL, Brumshtein B, Morton CL, Yoon KJ, Wadkins RM, Silman I, Sussman JL, Potter PM. The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action. Molecular Pharmacology. 67: 1874-81. PMID 15772291 DOI: 10.1124/Mol.104.009944  0.361
2004 Wadkins RM, Bearss D, Manikumar G, Wani MC, Wall ME, Von Hoff DD. Hydrophilic camptothecin analogs that form extremely stable cleavable complexes with DNA and topoisomerase I. Cancer Research. 64: 6679-83. PMID 15374984 DOI: 10.1158/0008-5472.Can-04-1885  0.339
2004 Wadkins RM, Bearss D, Manikumar G, Wani MC, Wall ME, Von Hoff DD. Topoisomerase I-DNA complex stability induced by camptothecins and its role in drug activity. Current Medicinal Chemistry. Anti-Cancer Agents. 4: 327-34. PMID 15281905 DOI: 10.2174/1568011043352894  0.394
2004 Wadkins RM, Hyatt JL, Yoon KJ, Morton CL, Lee RE, Damodaran K, Beroza P, Danks MK, Potter PM. Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity. Molecular Pharmacology. 65: 1336-43. PMID 15155827 DOI: 10.1124/Mol.65.6.1336  0.361
2001 Vekshin N, Savintsev I, Kovalev A, Yelemessov R, Wadkins RM. Solvatochromism of the excitation and emission spectra of 7-aminoactinomycin D: Implications for drug recognition of DNA secondary structures Journal of Physical Chemistry B. 105: 8461-8467. DOI: 10.1021/Jp011168P  0.413
2000 Wadkins RM. Targeting DNA secondary structures Current Medicinal Chemistry. 7: 1-15. PMID 10637354  0.346
1998 Wadkins RM, Vladu B, Tung CS. Actinomycin D binds to metastable hairpins in single-stranded DNA Biochemistry. 37: 11915-11923. PMID 9718315 DOI: 10.1021/Bi9809730  0.397
1998 Wadkins RM, Danks MK, Horowitz L, Baker SD. Characterization of topotecan-mediated redistribution of DNA topoisomerase I by digital imaging microscopy Experimental Cell Research. 241: 332-339. PMID 9637775 DOI: 10.1006/Excr.1998.4033  0.318
1996 Wadkins RM, Jares-Erijman EA, Klement R, Rüdiger A, Jovin TM. Actinomycin D binding to single-stranded DNA: Sequence specificity and hemi-intercalation model from fluorescence and 1H NMR spectroscopy Journal of Molecular Biology. 262: 53-68. PMID 8809179 DOI: 10.1006/jmbi.1996.0498  0.323
1995 Baker SD, Wadkins RM, Stewart CF, Beck WT, Danks MK. Cell cycle analysis of amount and distribution of nuclear DNA topoisomerase I as determined by fluorescence digital imaging microscopy Cytometry. 19: 134-145. PMID 7743894 DOI: 10.1002/Cyto.990190208  0.331
1993 Wadkins RM, Houghton PJ. Kinetics of cellular permeability of phenoxazine and its dependence on P-glycoprotein expression Febs Letters. 322: 1-5. PMID 8097728 DOI: 10.1016/0014-5793(93)81098-K  0.301
1993 Wadkins RM, Houghton PJ. The role of drug-lipid interactions in the biological activity of modulators of multi-drug resistance Bba - Biomembranes. 1153: 225-236. PMID 7903866 DOI: 10.1016/0005-2736(93)90409-S  0.304
1989 Wadkins RM, Graves DE. Thermodynamics of the interactions of m-AMSA and o-AMSA with nucleic acids: Influence of ionic strength and DNA base composition Nucleic Acids Research. 17: 9933-9946. PMID 2602146 DOI: 10.1093/Nar/17.23.9933  0.36
1988 Elmore RH, Wadkins RM, Graves DE. Cooperative binding of m-AMSA to nucleic acids Nucleic Acids Research. 16: 9707-9719. PMID 3186443 DOI: 10.1093/Nar/16.20.9707  0.354
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