Michael Otto, Ph.D. - Publications

Lab of Human Bacterial Pathogenesis Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT, United States 
Innate immunity, Staphylococcus aureus

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Year Citation  Score
2019 Le KY, Villaruz AE, Zheng Y, He L, Fisher EL, Nguyen TH, Ho TV, Yeh AJ, Joo HS, Cheung GYC, Otto M. Role of Phenol-Soluble Modulins in Staphylococcus epidermidis Biofilm Formation and Infection of Indwelling Medical Devices. Journal of Molecular Biology. PMID 30954574 DOI: 10.1016/j.jmb.2019.03.030  0.44
2019 He L, Le KY, Khan BA, Nguyen TH, Hunt RL, Bae JS, Kabat J, Zheng Y, Cheung GYC, Li M, Otto M. Resistance to leukocytes ties benefits of quorum sensing dysfunctionality to biofilm infection. Nature Microbiology. PMID 30936487 DOI: 10.1038/s41564-019-0413-x  0.44
2018 Piewngam P, Zheng Y, Nguyen TH, Dickey SW, Joo HS, Villaruz AE, Glose KA, Fisher EL, Hunt RL, Li B, Chiou J, Pharkjaksu S, Khongthong S, Cheung GYC, Kiratisin P, ... Otto M, et al. Pathogen elimination by probiotic Bacillus via signalling interference. Nature. PMID 30305736 DOI: 10.1038/s41586-018-0616-y  0.44
2018 Cheung GY, Otto M. Do antimicrobial peptides and antimicrobial-peptide resistance play important roles during bacterial infection? Future Microbiology. PMID 30113237 DOI: 10.2217/fmb-2018-0138  0.36
2018 Fisher EL, Otto M, Cheung GYC. Basis of Virulence in Enterotoxin-Mediated Staphylococcal Food Poisoning. Frontiers in Microbiology. 9: 436. PMID 29662470 DOI: 10.3389/fmicb.2018.00436  0.44
2018 Cheung GYC, Fisher EL, McCausland JW, Choi J, Collins JWM, Dickey SW, Otto M. Antimicrobial peptide resistance mechanism contributes to Staphylococcus aureus infection. The Journal of Infectious Diseases. PMID 29351622 DOI: 10.1093/infdis/jiy024  0.44
2017 Da F, Joo HS, Cheung GYC, Villaruz AE, Rohde H, Luo X, Otto M. Phenol-Soluble Modulin Toxins of Staphylococcus haemolyticus. Frontiers in Cellular and Infection Microbiology. 7: 206. PMID 28596942 DOI: 10.3389/fcimb.2017.00206  0.44
2017 Dickey SW, Cheung GY, Otto M. Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance. Nature Reviews. Drug Discovery. PMID 28337021 DOI: 10.1038/nrd.2017.23  0.36
2017 Qin L, Da F, Fisher EL, Tan DC, Nguyen TH, Fu CL, Tan VY, McCausland JW, Sturdevant DE, Joo HS, Queck SY, Cheung GY, Otto M. Toxin Mediates Sepsis Caused by Methicillin-Resistant Staphylococcus epidermidis. Plos Pathogens. 13: e1006153. PMID 28151994 DOI: 10.1371/journal.ppat.1006153  0.44
2016 Surewaard BG, Deniset JF, Zemp FJ, Amrein M, Otto M, Conly J, Omri A, Yates RM, Kubes P. Correction: Identification and treatment of the Staphylococcus aureus reservoir in vivo. The Journal of Experimental Medicine. 213: 3087. PMID 27956589 DOI: 10.1084/jem.2016033411032016c  0.32
2016 Nygaard TK, Kobayashi SD, Freedman B, Porter AR, Voyich JM, Otto M, Schneewind O, DeLeo FR. Interaction of Staphylococci with Human B cells. Plos One. 11: e0164410. PMID 27711145 DOI: 10.1371/journal.pone.0164410  0.76
2016 Mansour SC, Pletzer D, de la Fuente-Núñez C, Kim P, Cheung GY, Joo HS, Otto M, Hancock RE. Bacterial Abscess Formation Is Controlled by the Stringent Stress Response and Can Be Targeted Therapeutically. Ebiomedicine. PMID 27658736 DOI: 10.1016/j.ebiom.2016.09.015  0.36
2016 Qin L, McCausland JW, Cheung GY, Otto M. PSM-Mec-A Virulence Determinant that Connects Transcriptional Regulation, Virulence, and Antibiotic Resistance in Staphylococci. Frontiers in Microbiology. 7: 1293. PMID 27597849 DOI: 10.3389/fmicb.2016.01293  0.52
2016 Surewaard BG, Deniset JF, Zemp FJ, Amrein M, Otto M, Conly J, Omri A, Yates RM, Kubes P. Identification and treatment of the Staphylococcus aureus reservoir in vivo. The Journal of Experimental Medicine. PMID 27325887 DOI: 10.1084/jem.20160334  0.32
2016 Joo HS, Fu CI, Otto M. Bacterial strategies of resistance to antimicrobial peptides. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 371. PMID 27160595 DOI: 10.1098/rstb.2015.0292  0.52
2016 Wang Y, Hu M, Liu Q, Qin J, Dai Y, He L, Li T, Zheng B, Zhou F, Yu K, Fang J, Liu X, Otto M, Li M. Role of the ESAT-6 secretion system in virulence of the emerging community-associated Staphylococcus aureus lineage ST398. Scientific Reports. 6: 25163. PMID 27112266 DOI: 10.1038/srep25163  0.52
2016 Qi R, Joo HS, Sharma-Kuinkel B, Berlon NR, Park L, Fu CL, Messina JA, Thaden JT, Yan Q, Ruffin F, Maskarinec S, Warren B, Chu VH, Fortes CQ, Giannitsioti E, ... ... Otto M, et al. Increased in vitro phenol-soluble modulin production is associated with soft tissue infection source in clinical isolates of methicillin-susceptible Staphylococcus aureus. The Journal of Infection. PMID 26778460 DOI: 10.1016/j.jinf.2015.11.002  0.52
2016 Bonesso MF, Yeh AJ, Villaruz AE, Joo HS, McCausland J, Fortaleza CM, Cavalcante RS, Sobrinho MT, Ronchi CF, Cheung GY, Cunha ML, Otto M. Key Role of α-Toxin in Fatal Pneumonia Caused by Staphylococcus aureus Sequence Type 398. American Journal of Respiratory and Critical Care Medicine. 193: 217-20. PMID 26771417 DOI: 10.1164/rccm.201506-1225LE  0.36
2015 Li T, He L, Song Y, Villaruz AE, Joo HS, Liu Q, Zhu Y, Wang Y, Qin J, Otto M, Li M. AraC-type regulator Rsp adapts Staphylococcus aureus gene expression to acute infection. Infection and Immunity. PMID 26712209 DOI: 10.1128/IAI.01088-15  0.52
2015 Vural A, Al-Khodor S, Cheung GY, Shi CS, Srinivasan L, McQuiston TJ, Hwang IY, Yeh AJ, Blumer JB, Briken V, Williamson PR, Otto M, Fraser ID, Kehrl JH. Activator of G-Protein Signaling 3-Induced Lysosomal Biogenesis Limits Macrophage Intracellular Bacterial Infection. Journal of Immunology (Baltimore, Md. : 1950). PMID 26667172 DOI: 10.4049/jimmunol.1501595  0.44
2015 Cheung GY, Yeh AJ, Kretschmer D, Duong AC, Tuffuor K, Fu CL, Joo HS, Diep BA, Li M, Nakamura Y, Nunez G, Peschel A, Otto M. Functional characteristics of the Staphylococcus aureus δ-toxin allelic variant G10S. Scientific Reports. 5: 18023. PMID 26658455 DOI: 10.1038/srep18023  0.52
2015 Manifold-Wheeler BC, Elmore BO, Triplett KD, Castleman MJ, Otto M, Hall PR. Serum Lipoproteins Are Critical for Pulmonary Innate Defense against Staphylococcus aureus Quorum Sensing. Journal of Immunology (Baltimore, Md. : 1950). PMID 26608923 DOI: 10.4049/jimmunol.1501835  0.52
2015 Scharschmidt TC, Vasquez KS, Truong HA, Gearty SV, Pauli ML, Nosbaum A, Gratz IK, Otto M, Moon JJ, Liese J, Abbas AK, Fischbach MA, Rosenblum MD. A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes. Immunity. 43: 1011-1021. PMID 26588783 DOI: 10.1016/j.immuni.2015.10.016  0.52
2015 Le KY, Otto M. Quorum-sensing regulation in staphylococci-an overview. Frontiers in Microbiology. 6: 1174. PMID 26579084 DOI: 10.3389/fmicb.2015.01174  0.52
2015 Vuong C, Yeh AJ, Cheung GY, Otto M. Investigational drugs to treat methicillin-resistant Staphylococcus aureus. Expert Opinion On Investigational Drugs. 1-21. PMID 26536498 DOI: 10.1517/13543784.2016.1109077  0.52
2015 Berlon NR, Qi R, Sharma-Kuinkel BK, Joo HS, Park LP, George D, Thaden JT, Messina JA, Maskarinec SA, Mueller-Premru M, Athan E, Tattevin P, Pericas JM, Woods CW, Otto M, et al. Clinical MRSA isolates from skin and soft tissue infections show increased in vitro production of phenol soluble modulins. The Journal of Infection. PMID 26079275 DOI: 10.1016/j.jinf.2015.06.005  0.52
2015 Dastgheyb SS, Villaruz AE, Le KY, Tan VY, Duong AC, Chatterjee SS, Cheung GY, Joo HS, Hickok NJ, Otto M. Role of Phenol-Soluble Modulins in Formation of Staphylococcus aureus Biofilms in Synovial Fluid. Infection and Immunity. 83: 2966-75. PMID 25964472 DOI: 10.1128/IAI.00394-15  0.52
2015 Kamenyeva O, Boularan C, Kabat J, Cheung GY, Cicala C, Yeh AJ, Chan JL, Periasamy S, Otto M, Kehrl JH. Neutrophil recruitment to lymph nodes limits local humoral response to Staphylococcus aureus. Plos Pathogens. 11: e1004827. PMID 25884622 DOI: 10.1371/journal.ppat.1004827  0.52
2015 Dastgheyb S, Hickok NJ, Otto M. Reply to Perez and Patel. The Journal of Infectious Diseases. 212: 336-7. PMID 25712972 DOI: 10.1093/infdis/jiv097  0.52
2015 Khan BA, Yeh AJ, Cheung GY, Otto M. Investigational therapies targeting quorum-sensing for the treatment of Staphylococcus aureus infections. Expert Opinion On Investigational Drugs. 24: 689-704. PMID 25704585 DOI: 10.1517/13543784.2015.1019062  0.52
2015 Deplanche M, Filho RA, Alekseeva L, Ladier E, Jardin J, Henry G, Azevedo V, Miyoshi A, Beraud L, Laurent F, Lina G, Vandenesch F, Steghens JP, Le Loir Y, Otto M, et al. Phenol-soluble modulin α induces G2/M phase transition delay in eukaryotic HeLa cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 29: 1950-9. PMID 25648996 DOI: 10.1096/fj.14-260513  0.52
2015 Dastgheyb SS, Hammoud S, Ketonis C, Liu AY, Fitzgerald K, Parvizi J, Purtill J, Ciccotti M, Shapiro IM, Otto M, Hickok NJ. Staphylococcal persistence due to biofilm formation in synovial fluid containing prophylactic cefazolin. Antimicrobial Agents and Chemotherapy. 59: 2122-8. PMID 25624333 DOI: 10.1128/AAC.04579-14  0.52
2015 Cheung GY, Otto M. Microbiology: Diverted on the way to memory. Nature. 517: 28-9. PMID 25487148 DOI: 10.1038/nature14083  0.52
2015 Dastgheyb S, Parvizi J, Shapiro IM, Hickok NJ, Otto M. Effect of biofilms on recalcitrance of staphylococcal joint infection to antibiotic treatment. The Journal of Infectious Diseases. 211: 641-50. PMID 25214518 DOI: 10.1093/infdis/jiu514  0.52
2015 Chen Y, Yeh AJ, Cheung GY, Villaruz AE, Tan VY, Joo HS, Chatterjee SS, Yu Y, Otto M. Basis of virulence in a Panton-Valentine leukocidin-negative community-associated methicillin-resistant Staphylococcus aureus strain. The Journal of Infectious Diseases. 211: 472-80. PMID 25139021 DOI: 10.1093/infdis/jiu462  0.52
2014 Le KY, Dastgheyb S, Ho TV, Otto M. Molecular determinants of staphylococcal biofilm dispersal and structuring. Frontiers in Cellular and Infection Microbiology. 4: 167. PMID 25505739 DOI: 10.3389/fcimb.2014.00167  0.52
2014 Cheung GY, Kretschmer D, Duong AC, Yeh AJ, Ho TV, Chen Y, Joo HS, Kreiswirth BN, Peschel A, Otto M. Production of an attenuated phenol-soluble modulin variant unique to the MRSA clonal complex 30 increases severity of bloodstream infection. Plos Pathogens. 10: e1004298. PMID 25144687 DOI: 10.1371/journal.ppat.1004298  0.52
2014 Sully EK, Malachowa N, Elmore BO, Alexander SM, Femling JK, Gray BM, DeLeo FR, Otto M, Cheung AL, Edwards BS, Sklar LA, Horswill AR, Hall PR, Gresham HD. Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance. Plos Pathogens. 10: e1004174. PMID 24945495 DOI: 10.1371/journal.ppat.1004174  0.52
2014 Cheung GY, Villaruz AE, Joo HS, Duong AC, Yeh AJ, Nguyen TH, Sturdevant DE, Queck SY, Otto M. Genome-wide analysis of the regulatory function mediated by the small regulatory psm-mec RNA of methicillin-resistant Staphylococcus aureus. International Journal of Medical Microbiology : Ijmm. 304: 637-44. PMID 24877726 DOI: 10.1016/j.ijmm.2014.04.008  0.52
2014 Stavrakis AI, Niska JA, Shahbazian JH, Loftin AH, Ramos RI, Billi F, Francis KP, Otto M, Bernthal NM, Uslan DZ, Miller LS. Combination prophylactic therapy with rifampin increases efficacy against an experimental Staphylococcus epidermidis subcutaneous implant-related infection. Antimicrobial Agents and Chemotherapy. 58: 2377-86. PMID 24514089 DOI: 10.1128/AAC.01943-13  0.52
2014 Cheung GY, Joo HS, Chatterjee SS, Otto M. Phenol-soluble modulins--critical determinants of staphylococcal virulence. Fems Microbiology Reviews. 38: 698-719. PMID 24372362 DOI: 10.1111/1574-6976.12057  0.52
2014 Rudkin JK, Laabei M, Edwards AM, Joo HS, Otto M, Lennon KL, O'Gara JP, Waterfield NR, Massey RC. Oxacillin alters the toxin expression profile of community-associated methicillin-resistant Staphylococcus aureus. Antimicrobial Agents and Chemotherapy. 58: 1100-7. PMID 24295979 DOI: 10.1128/AAC.01618-13  0.52
2014 Joo HS, Otto M. The isolation and analysis of phenol-soluble modulins of Staphylococcus epidermidis. Methods in Molecular Biology (Clifton, N.J.). 1106: 93-100. PMID 24222457 DOI: 10.1007/978-1-62703-736-5_7  0.52
2014 Cheung GY, Kretschmer D, Queck SY, Joo HS, Wang R, Duong AC, Nguyen TH, Bach TH, Porter AR, DeLeo FR, Peschel A, Otto M. Insight into structure-function relationship in phenol-soluble modulins using an alanine screen of the phenol-soluble modulin (PSM) α3 peptide. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 153-61. PMID 24008753 DOI: 10.1096/fj.13-232041  0.52
2014 Uhlemann AC, Otto M, Lowy FD, DeLeo FR. Evolution of community- and healthcare-associated methicillin-resistant Staphylococcus aureus. Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases. 21: 563-74. PMID 23648426 DOI: 10.1016/j.meegid.2013.04.030  0.76
2013 Nakamura Y, Oscherwitz J, Cease KB, Chan SM, Muñoz-Planillo R, Hasegawa M, Villaruz AE, Cheung GY, McGavin MJ, Travers JB, Otto M, Inohara N, Núñez G. Staphylococcus δ-toxin induces allergic skin disease by activating mast cells. Nature. 503: 397-401. PMID 24172897 DOI: 10.1038/nature12655  0.52
2013 Kobayashi SD, Olsen RJ, LaCasse RA, Safronetz D, Ashraf M, Porter AR, Braughton KR, Feldmann F, Clifton DR, Kash JC, Bailey JR, Gardner DJ, Otto M, Brining DL, Kreiswirth BN, et al. Seasonal H3N2 influenza A virus fails to enhance Staphylococcus aureus co-infection in a non-human primate respiratory tract infection model. Virulence. 4: 707-15. PMID 24104465 DOI: 10.4161/viru.26572  0.52
2013 Chen J, Feng G, Guo Q, Wardenburg JB, Lin S, Inoshima I, Deaton R, Yuan JX, Garcia JG, Machado RF, Otto M, Wunderink RG. Transcriptional events during the recovery from MRSA lung infection: a mouse pneumonia model. Plos One. 8: e70176. PMID 23936388 DOI: 10.1371/journal.pone.0070176  0.52
2013 Chen J, Feng G, Song Y, Wardenburg JB, Lin S, Inoshima I, Otto M, Wunderink RG. Linezolid Exerts Greater Bacterial Clearance but No Modification of Host Lung Gene Expression Profiling: A Mouse MRSA Pneumonia Model. Plos One. 8: e67994. PMID 23826353 DOI: 10.1371/journal.pone.0067994  0.52
2013 Surewaard BG, de Haas CJ, Vervoort F, Rigby KM, DeLeo FR, Otto M, van Strijp JA, Nijland R. Staphylococcal alpha-phenol soluble modulins contribute to neutrophil lysis after phagocytosis. Cellular Microbiology. 15: 1427-37. PMID 23470014 DOI: 10.1111/cmi.12130  0.76
2013 Hall PR, Elmore BO, Spang CH, Alexander SM, Manifold-Wheeler BC, Castleman MJ, Daly SM, Peterson MM, Sully EK, Femling JK, Otto M, Horswill AR, Timmins GS, Gresham HD. Nox2 modification of LDL is essential for optimal apolipoprotein B-mediated control of agr type III Staphylococcus aureus quorum-sensing. Plos Pathogens. 9: e1003166. PMID 23459693 DOI: 10.1371/journal.ppat.1003166  0.52
2013 Chatterjee SS, Joo HS, Duong AC, Dieringer TD, Tan VY, Song Y, Fischer ER, Cheung GY, Li M, Otto M. Essential Staphylococcus aureus toxin export system. Nature Medicine. 19: 364-7. PMID 23396209 DOI: 10.1038/nm.3047  0.36
2012 Duong AC, Cheung GY, Otto M. Interaction of phenol-soluble modulins with phosphatidylcholine vesicles. Pathogens (Basel, Switzerland). 1: 3-11. PMID 25436601 DOI: 10.3390/pathogens1010003  0.36
2012 Kronforst KD, Mancuso CJ, Pettengill M, Ninkovic J, Power Coombs MR, Stevens C, Otto M, Mallard C, Wang X, Goldmann D, Levy O. A neonatal model of intravenous Staphylococcus epidermidis infection in mice <24 h old enables characterization of early innate immune responses. Plos One. 7: e43897. PMID 22970147 DOI: 10.1371/journal.pone.0043897  0.52
2012 Christner M, Heinze C, Busch M, Franke G, Hentschke M, Bayard Dühring S, Büttner H, Kotasinska M, Wischnewski V, Kroll G, Buck F, Molin S, Otto M, Rohde H. sarA negatively regulates Staphylococcus epidermidis biofilm formation by modulating expression of 1 MDa extracellular matrix binding protein and autolysis-dependent release of eDNA. Molecular Microbiology. 86: 394-410. PMID 22957858 DOI: 10.1111/j.1365-2958.2012.08203.x  0.52
2012 Periasamy S, Chatterjee SS, Cheung GY, Otto M. Phenol-soluble modulins in staphylococci: What are they originally for? Communicative & Integrative Biology. 5: 275-7. PMID 22896791 DOI: 10.4161/cib.19420  0.36
2012 Conlan S, Mijares LA, Becker J, Blakesley RW, Bouffard GG, Brooks S, Coleman H, Gupta J, Gurson N, Park M, Schmidt B, Thomas PJ, Otto M, Kong HH, et al. Staphylococcus epidermidis pan-genome sequence analysis reveals diversity of skin commensal and hospital infection-associated isolates. Genome Biology. 13: R64. PMID 22830599 DOI: 10.1186/gb-2012-13-7-r64  0.52
2012 Cheung GY, Otto M. The potential use of toxin antibodies as a strategy for controlling acute Staphylococcus aureus infections. Expert Opinion On Therapeutic Targets. 16: 601-12. PMID 22530584 DOI: 10.1517/14728222.2012.682573  0.36
2012 Li M, Du X, Villaruz AE, Diep BA, Wang D, Song Y, Tian Y, Hu J, Yu F, Lu Y, Otto M. MRSA epidemic linked to a quickly spreading colonization and virulence determinant. Nature Medicine. 18: 816-9. PMID 22522561 DOI: 10.1038/nm.2692  0.52
2012 Periasamy S, Joo HS, Duong AC, Bach TH, Tan VY, Chatterjee SS, Cheung GY, Otto M. How Staphylococcus aureus biofilms develop their characteristic structure. Proceedings of the National Academy of Sciences of the United States of America. 109: 1281-6. PMID 22232686 DOI: 10.1073/pnas.1115006109  0.52
2012 Cheung GY, Duong AC, Otto M. Direct and synergistic hemolysis caused by Staphylococcus phenol-soluble modulins: implications for diagnosis and pathogenesis. Microbes and Infection / Institut Pasteur. 14: 380-6. PMID 22178792 DOI: 10.1016/j.micinf.2011.11.013  0.36
2011 Chatterjee SS, Chen L, Joo HS, Cheung GY, Kreiswirth BN, Otto M. Distribution and regulation of the mobile genetic element-encoded phenol-soluble modulin PSM-mec in methicillin-resistant Staphylococcus aureus. Plos One. 6: e28781. PMID 22174895 DOI: 10.1371/journal.pone.0028781  0.52
2011 DeLeo FR, Kennedy AD, Chen L, Bubeck Wardenburg J, Kobayashi SD, Mathema B, Braughton KR, Whitney AR, Villaruz AE, Martens CA, Porcella SF, McGavin MJ, Otto M, Musser JM, Kreiswirth BN. Molecular differentiation of historic phage-type 80/81 and contemporary epidemic Staphylococcus aureus. Proceedings of the National Academy of Sciences of the United States of America. 108: 18091-6. PMID 22025717 DOI: 10.1073/pnas.1111084108  0.52
2011 Kobayashi SD, Malachowa N, Whitney AR, Braughton KR, Gardner DJ, Long D, Bubeck Wardenburg J, Schneewind O, Otto M, Deleo FR. Comparative analysis of USA300 virulence determinants in a rabbit model of skin and soft tissue infection. The Journal of Infectious Diseases. 204: 937-41. PMID 21849291 DOI: 10.1093/infdis/jir441  0.52
2011 Malachowa N, Whitney AR, Kobayashi SD, Sturdevant DE, Kennedy AD, Braughton KR, Shabb DW, Diep BA, Chambers HF, Otto M, DeLeo FR. Global changes in Staphylococcus aureus gene expression in human blood. Plos One. 6: e18617. PMID 21525981 DOI: 10.1371/journal.pone.0018617  0.52
2011 Rosenthal ME, Dever LL, Moucha CS, Chavda KD, Otto M, Kreiswirth BN. Molecular characterization of an early invasive Staphylococcus epidermidis prosthetic joint infection. Microbial Drug Resistance (Larchmont, N.Y.). 17: 345-50. PMID 21510745 DOI: 10.1089/mdr.2010.0157  0.52
2011 Zielinska AK, Beenken KE, Joo HS, Mrak LN, Griffin LM, Luong TT, Lee CY, Otto M, Shaw LN, Smeltzer MS. Defining the strain-dependent impact of the Staphylococcal accessory regulator (sarA) on the alpha-toxin phenotype of Staphylococcus aureus. Journal of Bacteriology. 193: 2948-58. PMID 21478342 DOI: 10.1128/JB.01517-10  0.52
2011 Cheung GY, Wang R, Khan BA, Sturdevant DE, Otto M. Role of the accessory gene regulator agr in community-associated methicillin-resistant Staphylococcus aureus pathogenesis. Infection and Immunity. 79: 1927-35. PMID 21402769 DOI: 10.1128/IAI.00046-11  0.44
2011 Joo HS, Cheung GY, Otto M. Antimicrobial activity of community-associated methicillin-resistant Staphylococcus aureus is caused by phenol-soluble modulin derivatives. The Journal of Biological Chemistry. 286: 8933-40. PMID 21278255 DOI: 10.1074/jbc.M111.221382  0.36
2011 Wang R, Khan BA, Cheung GY, Bach TH, Jameson-Lee M, Kong KF, Queck SY, Otto M. Staphylococcus epidermidis surfactant peptides promote biofilm maturation and dissemination of biofilm-associated infection in mice. The Journal of Clinical Investigation. 121: 238-48. PMID 21135501 DOI: 10.1172/JCI42520  0.44
2010 Li M, Cheung GY, Hu J, Wang D, Joo HS, Deleo FR, Otto M. Comparative analysis of virulence and toxin expression of global community-associated methicillin-resistant Staphylococcus aureus strains. The Journal of Infectious Diseases. 202: 1866-76. PMID 21050125 DOI: 10.1086/657419  0.76
2010 Cheung GY, Rigby K, Wang R, Queck SY, Braughton KR, Whitney AR, Teintze M, DeLeo FR, Otto M. Staphylococcus epidermidis strategies to avoid killing by human neutrophils. Plos Pathogens. 6: e1001133. PMID 20949069 DOI: 10.1371/journal.ppat.1001133  0.52
2010 Joo HS, Chan JL, Cheung GY, Otto M. Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus. Antimicrobial Agents and Chemotherapy. 54: 4942-4. PMID 20713669 DOI: 10.1128/AAC.00064-10  0.52
2010 DeLeo FR, Otto M, Kreiswirth BN, Chambers HF. Community-associated meticillin-resistant Staphylococcus aureus. Lancet. 375: 1557-68. PMID 20206987 DOI: 10.1016/S0140-6736(09)61999-1  0.52
2010 Graves SF, Kobayashi SD, Braughton KR, Diep BA, Chambers HF, Otto M, Deleo FR. Relative contribution of Panton-Valentine leukocidin to PMN plasma membrane permeability and lysis caused by USA300 and USA400 culture supernatants. Microbes and Infection / Institut Pasteur. 12: 446-56. PMID 20172045 DOI: 10.1016/j.micinf.2010.02.005  0.52
2009 Queck SY, Khan BA, Wang R, Bach TH, Kretschmer D, Chen L, Kreiswirth BN, Peschel A, Deleo FR, Otto M. Mobile genetic element-encoded cytolysin connects virulence to methicillin resistance in MRSA. Plos Pathogens. 5: e1000533. PMID 19649313 DOI: 10.1371/journal.ppat.1000533  0.52
2009 Villaruz AE, Bubeck Wardenburg J, Khan BA, Whitney AR, Sturdevant DE, Gardner DJ, DeLeo FR, Otto M. A point mutation in the agr locus rather than expression of the Panton-Valentine leukocidin caused previously reported phenotypes in Staphylococcus aureus pneumonia and gene regulation. The Journal of Infectious Diseases. 200: 724-34. PMID 19604047 DOI: 10.1086/604728  0.76
2009 Voyich JM, Vuong C, DeWald M, Nygaard TK, Kocianova S, Griffith S, Jones J, Iverson C, Sturdevant DE, Braughton KR, Whitney AR, Otto M, DeLeo FR. The SaeR/S gene regulatory system is essential for innate immune evasion by Staphylococcus aureus. The Journal of Infectious Diseases. 199: 1698-706. PMID 19374556 DOI: 10.1086/598967  0.52
2009 Li M, Diep BA, Villaruz AE, Braughton KR, Jiang X, DeLeo FR, Chambers HF, Lu Y, Otto M. Evolution of virulence in epidemic community-associated methicillin-resistant Staphylococcus aureus. Proceedings of the National Academy of Sciences of the United States of America. 106: 5883-8. PMID 19293374 DOI: 10.1073/pnas.0900743106  0.52
2009 DeLeo FR, Diep BA, Otto M. Host defense and pathogenesis in Staphylococcus aureus infections. Infectious Disease Clinics of North America. 23: 17-34. PMID 19135914 DOI: 10.1016/j.idc.2008.10.003  0.52
2008 Diep BA, Palazzolo-Ballance AM, Tattevin P, Basuino L, Braughton KR, Whitney AR, Chen L, Kreiswirth BN, Otto M, DeLeo FR, Chambers HF. Contribution of Panton-Valentine leukocidin in community-associated methicillin-resistant Staphylococcus aureus pathogenesis. Plos One. 3: e3198. PMID 18787708 DOI: 10.1371/journal.pone.0003198  0.52
2008 Bubeck Wardenburg J, Palazzolo-Ballance AM, Otto M, Schneewind O, DeLeo FR. Panton-Valentine leukocidin is not a virulence determinant in murine models of community-associated methicillin-resistant Staphylococcus aureus disease. The Journal of Infectious Diseases. 198: 1166-70. PMID 18729780 DOI: 10.1086/592053  0.52
2008 Otto M, DeLeo FR. Methods molecular biology. Preface. Methods in Molecular Biology (Clifton, N.J.). 431: V-VI. PMID 18421842  0.76
2008 DeLeo FR, Otto M. An antidote for Staphylococcus aureus pneumonia? The Journal of Experimental Medicine. 205: 271-4. PMID 18268043 DOI: 10.1084/jem.20080167  0.76
2008 Kennedy AD, Otto M, Braughton KR, Whitney AR, Chen L, Mathema B, Mediavilla JR, Byrne KA, Parkins LD, Tenover FC, Kreiswirth BN, Musser JM, DeLeo FR. Epidemic community-associated methicillin-resistant Staphylococcus aureus: recent clonal expansion and diversification. Proceedings of the National Academy of Sciences of the United States of America. 105: 1327-32. PMID 18216255 DOI: 10.1073/pnas.0710217105  0.52
2008 Palazzolo-Ballance AM, Reniere ML, Braughton KR, Sturdevant DE, Otto M, Kreiswirth BN, Skaar EP, DeLeo FR. Neutrophil microbicides induce a pathogen survival response in community-associated methicillin-resistant Staphylococcus aureus. Journal of Immunology (Baltimore, Md. : 1950). 180: 500-9. PMID 18097052  0.52
2007 Bubeck Wardenburg J, Bae T, Otto M, Deleo FR, Schneewind O. Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia. Nature Medicine. 13: 1405-6. PMID 18064027 DOI: 10.1038/nm1207-1405  0.52
2007 Wang R, Braughton KR, Kretschmer D, Bach TH, Queck SY, Li M, Kennedy AD, Dorward DW, Klebanoff SJ, Peschel A, DeLeo FR, Otto M. Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA. Nature Medicine. 13: 1510-4. PMID 17994102 DOI: 10.1038/nm1656  0.52
2006 Voyich JM, Otto M, Mathema B, Braughton KR, Whitney AR, Welty D, Long RD, Dorward DW, Gardner DJ, Lina G, Kreiswirth BN, DeLeo FR. Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease? The Journal of Infectious Diseases. 194: 1761-70. PMID 17109350 DOI: 10.1086/509506  0.52
2005 Kocianova S, Vuong C, Yao Y, Voyich JM, Fischer ER, DeLeo FR, Otto M. Key role of poly-gamma-DL-glutamic acid in immune evasion and virulence of Staphylococcus epidermidis. The Journal of Clinical Investigation. 115: 688-94. PMID 15696197 DOI: 10.1172/JCI23523  0.52
2004 Vuong C, Kocianova S, Voyich JM, Yao Y, Fischer ER, DeLeo FR, Otto M. A crucial role for exopolysaccharide modification in bacterial biofilm formation, immune evasion, and virulence. The Journal of Biological Chemistry. 279: 54881-6. PMID 15501828 DOI: 10.1074/jbc.M411374200  0.52
2004 Voyich JM, Braughton KR, Sturdevant DE, Vuong C, Kobayashi SD, Porcella SF, Otto M, Musser JM, DeLeo FR. Engagement of the pathogen survival response used by group A Streptococcus to avert destruction by innate host defense. Journal of Immunology (Baltimore, Md. : 1950). 173: 1194-201. PMID 15240710  0.52
2004 Vuong C, Voyich JM, Fischer ER, Braughton KR, Whitney AR, DeLeo FR, Otto M. Polysaccharide intercellular adhesin (PIA) protects Staphylococcus epidermidis against major components of the human innate immune system. Cellular Microbiology. 6: 269-75. PMID 14764110 DOI: 10.1046/j.1462-5822.2004.00367.x  0.52
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