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Steven D. Townsend, Ph.D. - Publications

Affiliations: 
2010 Vanderbilt University, Nashville, TN 
Area:
Organic Chemistry, Biochemistry, glycobiology
Website:
www.townsendchemistry.org
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58 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Stephens VR, Moore RE, Spicer SK, Talbert JA, Lu J, Chinni R, Chambers SA, Townsend SD, Manning SD, Rogers LM, Aronoff DM, Vue Z, Neikirk K, Hinton AO, Damo SM, et al. Environmental Toxicant Exposure Paralyzes Human Placental Macrophage Responses to Microbial Threat. Acs Infectious Diseases. PMID 37955242 DOI: 10.1021/acsinfecdis.3c00490  0.729
2023 Moore RE, Spicer SK, Lu J, Chambers SA, Noble KN, Lochner J, Christofferson RC, Vasco KA, Manning SD, Townsend SD, Gaddy JA. The Utility of Human Milk Oligosaccharides against Group B Infections of Reproductive Tissues and Cognate Adverse Pregnancy Outcomes. Acs Central Science. 9: 1737-1749. PMID 37780357 DOI: 10.1021/acscentsci.3c00101  0.751
2023 Moore R, Spicer S, Talbert J, Manning S, Townsend S, Gaddy J. Anti-Biofilm Activity of Human Milk Oligosaccharides in Clinical Strains of Streptococcus agalactiae with Diverse Capsular and Sequence Types. Chembiochem : a European Journal of Chemical Biology. PMID 36622717 DOI: 10.1002/cbic.202200643  0.676
2022 Lu J, Moore RE, Spicer SK, Doster RS, Guevara MA, Francis JD, Noble KN, Rogers LM, Talbert JA, Korir ML, Townsend SD, Aronoff DM, Manning SD, Gaddy JA. Streptococcus agalactiae Is Required for Survival in Human Placental Macrophages and Full Virulence in a Model of Ascending Vaginal Infection during Pregnancy. Mbio. e0287022. PMID 36409087 DOI: 10.1128/mbio.02870-22  0.649
2022 Talbert JA, Lu J, Spicer SK, Moore RE, Townsend SD, Gaddy JA. Ameliorating adverse perinatal outcomes with Lactoferrin: An intriguing chemotherapeutic intervention. Bioorganic & Medicinal Chemistry. 74: 117037. PMID 36215812 DOI: 10.1016/j.bmc.2022.117037  0.636
2022 Korir ML, Doster RS, Lu J, Guevara MA, Spicer SK, Moore RE, Francis JD, Rogers LM, Haley KP, Blackman A, Noble KN, Eastman AJ, Williams JA, Damo SM, Boyd KL, ... Townsend SD, et al. Streptococcus agalactiae cadD alleviates metal stress and promotes intracellular survival in macrophages and ascending infection during pregnancy. Nature Communications. 13: 5392. PMID 36104331 DOI: 10.1038/s41467-022-32916-7  0.639
2022 Spicer SK, Gaddy JA, Townsend SD. Recent advances on human milk oligosaccharide antimicrobial activity. Current Opinion in Chemical Biology. 71: 102202. PMID 36063785 DOI: 10.1016/j.cbpa.2022.102202  0.306
2022 Nguyen JM, Evans CS, Wright NM, Townsend SD. Synthesis of the Aeromonas veronii strain Bs8 disaccharide repeating unit. Carbohydrate Research. 514: 108530. PMID 35263695 DOI: 10.1016/j.carres.2022.108530  0.761
2021 Spicer SK, Moore RE, Lu J, Guevara MA, Marshall DR, Manning SD, Damo SM, Townsend SD, Gaddy JA. Antibiofilm Activity of Human Milk Oligosaccharides against Multidrug Resistant and Susceptible Isolates of . Acs Infectious Diseases. PMID 34812035 DOI: 10.1021/acsinfecdis.1c00420  0.696
2021 Moore RE, Thomas HC, Manning SD, Gaddy JA, Townsend S. Galacto-oligosaccharide Supplementation Modulates Pathogen-Commensal Competition between Streptococcus agalactiae and Streptococcus salivarius. Chembiochem : a European Journal of Chemical Biology. PMID 34788501 DOI: 10.1002/cbic.202100559  0.65
2021 Lu J, Guevara MA, Francis JD, Spicer SK, Moore RE, Chambers SA, Craft KM, Manning SD, Townsend SD, Gaddy JA. Analysis of Susceptibility to the Antimicrobial and Anti-Biofilm Activity of Human Milk Lactoferrin in Clinical Strains of With Diverse Capsular and Sequence Types. Frontiers in Cellular and Infection Microbiology. 11: 740872. PMID 34616691 DOI: 10.3389/fcimb.2021.740872  0.803
2021 Moore RE, Townsend SD, Gaddy J. The diverse antimicrobial activities of human milk oligosaccharides against Group B Streptococcus. Chembiochem : a European Journal of Chemical Biology. PMID 34580974 DOI: 10.1002/cbic.202100423  0.697
2021 Huseman ED, Byl JAW, Chapp SM, Schley ND, Osheroff N, Townsend SD. Synthesis and Cytotoxic Evaluation of Arimetamycin A and Its Daunorubicin and Doxorubicin Hybrids. Acs Central Science. 7: 1327-1337. PMID 34471677 DOI: 10.1021/acscentsci.1c00040  0.774
2021 Nguyen JM, Townsend SD. Total Synthesis of the ssp. 3240 Zwitterionic Trisaccharide Repeating Unit. Organic Letters. PMID 34314177 DOI: 10.1021/acs.orglett.1c02023  0.78
2021 Xu LL, Townsend SD. Synthesis as an Expanding Resource in Human Milk Science. Journal of the American Chemical Society. PMID 34296874 DOI: 10.1021/jacs.1c05599  0.779
2021 Huseman ED, Townsend SD. ynthesis of an l-Lemonose Thioglycoside Donor from d-Threonine. Tetrahedron Letters. 73. PMID 34176980 DOI: 10.1016/j.tetlet.2021.153097  0.762
2021 Lu J, Haley K, Francis J, Guevara M, Doster R, Craft K, Moore R, Chambers S, Delgado A, Piazuelo MB, Damo S, Townsend S, Gaddy J. The innate immune glycoprotein lactoferrin represses the Helicobacter pylori cag type IV secretion system. Chembiochem : a European Journal of Chemical Biology. PMID 34169626 DOI: 10.1002/cbic.202100249  0.768
2021 Avery TM, Boone RL, Lu J, Spicer SK, Guevara MA, Moore RE, Chambers SA, Manning SD, Dent L, Marshall D, Damo SM, Townsend SD, Gaddy JA. Analysis of Antimicrobial and Antibiofilm Activity of Human Milk Lactoferrin Compared to Bovine Lactoferrin against Multidrug Resistant and Susceptible Clinical Isolates. Acs Infectious Diseases. PMID 34105954 DOI: 10.1021/acsinfecdis.1c00087  0.781
2021 Noble K, Lu J, Guevara MA, Doster RS, Chambers SA, Rogers LM, Moore RE, Spicer SK, Eastman AJ, Francis JD, Manning SD, Rajagopal L, Aronoff DM, Townsend SD, Gaddy JA. Group B Is Required for Serotype V Capsule Production and Aids in Biofilm Formation and Ascending Infection of the Reproductive Tract during Pregnancy. Acs Infectious Diseases. PMID 34076405 DOI: 10.1021/acsinfecdis.1c00182  0.757
2021 Nguyen JM, Moore RE, Spicer SK, Gaddy JA, Townsend S. Synthetic Phosphoethanolamine Cellobiose Promotes Escherichia coli Biofilm Formation and Congo Red Binding. Chembiochem : a European Journal of Chemical Biology. PMID 33890354 DOI: 10.1002/cbic.202000869  0.791
2021 Lu J, Francis JD, Guevara MA, Moore RE, Chambers SA, Doster RS, Eastman AJ, Rogers LM, Noble KN, Manning SD, Damo SM, Aronoff DM, Townsend SD, Gaddy JA. Antibacterial and Anti-biofilm Activity of the Human Breast Milk Glycoprotein Lactoferrin against Group B Streptococcus. Chembiochem : a European Journal of Chemical Biology. PMID 33755306 DOI: 10.1002/cbic.202100016  0.779
2021 Eastman AJ, Moore RE, Townsend SD, Gaddy JA, Aronoff DM. The Influence of Obesity and Associated Fatty Acids on Placental Inflammation. Clinical Therapeutics. PMID 33487441 DOI: 10.1016/j.clinthera.2020.12.018  0.575
2021 Moore RE, Xu LL, Townsend SD. Prospecting Human Milk Oligosaccharides as a Defense Against Viral Infections. Acs Infectious Diseases. PMID 33470804 DOI: 10.1021/acsinfecdis.0c00807  0.795
2021 Boone RL, Whitehead B, Avery TM, Lu J, Francis JD, Guevara MA, Moore RE, Chambers SA, Doster RS, Manning SD, Townsend SD, Dent L, Marshall D, Gaddy JA, Damo SM. Analysis of virulence phenotypes and antibiotic resistance in clinical strains of Acinetobacter baumannii isolated in Nashville, Tennessee. Bmc Microbiology. 21: 21. PMID 33422000 DOI: 10.1186/s12866-020-02082-1  0.739
2020 Guevara MA, Lu J, Moore RE, Chambers SA, Eastman AJ, Francis JD, Noble KN, Doster RS, Osteen KG, Damo SM, Manning SD, Aronoff DM, Halasa NB, Townsend SD, Gaddy JA. Vitamin D and Streptococci: The Interface of Nutrition, Host Immune Response, and Antimicrobial Activity in Response to Infection. Acs Infectious Diseases. PMID 33170652 DOI: 10.1021/acsinfecdis.0c00666  0.744
2020 Moore R, Craft KM, Xu LL, Chambers SA, Nguyen JM, Marion KC, Gaddy JA, Townsend SD. Leveraging Stereoelectronic Effects in Biofilm Eradication: Synthetic β-Amino Human Milk Oligosaccharides Impede Microbial Adhesion as Observed by Scanning Electron Microscopy. The Journal of Organic Chemistry. PMID 32996317 DOI: 10.1021/acs.joc.0c01958  0.745
2020 Chambers SA, Townsend SD. Two-step conversion of unprotected oligosaccharides to generate bioorthogonal oligosaccharide tool compounds. Methodsx. 7: 100996. PMID 32760661 DOI: 10.1016/J.Mex.2020.100996  0.58
2020 Chambers SA, Townsend SD. Like mother, like microbe: human milk oligosaccharide mediated microbiome symbiosis. Biochemical Society Transactions. PMID 32597470 DOI: 10.1042/Bst20191144  0.628
2020 Lu J, Francis J, Doster RS, Haley K, Craft KM, Moore R, Chambers SA, Aronoff DM, Osteen K, Damo S, Manning S, Townsend SD, Gaddy JA. Lactoferrin: a critical mediator of both host immune response and antimicrobial activity in response to streptococcal infections. Acs Infectious Diseases. PMID 32329605 DOI: 10.1021/Acsinfecdis.0C00050  0.784
2020 Carvalho A, Lu J, Francis JD, Moore RE, Haley KP, Doster RS, Townsend SD, Johnson JG, Damo SM, Gaddy JA. S100A12 in Digestive Diseases and Health: A Scoping Review. Gastroenterology Research and Practice. 2020: 2868373. PMID 32184815 DOI: 10.1155/2020/2868373  0.646
2020 Chambers SA, Moore RE, Craft KM, Thomas HC, Das R, Manning SD, Codreanu SG, Sherrod SD, Aronoff DM, McLean JA, Gaddy JA, Townsend SD. A Solution to Antifolate Resistance in Group B : Untargeted Metabolomics Identifies Human Milk Oligosaccharide-Induced Perturbations That Result in Potentiation of Trimethoprim. Mbio. 11. PMID 32184236 DOI: 10.1128/Mbio.00076-20  0.795
2020 Chambers SA, Gaddy J, Townsend S. Synthetic Ellagic Acid Glycosides Inhibit Early-Stage Adhesion of Streptococcus agalactiae Biofilms as Observed by Scanning Electron Microscopy. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 32084298 DOI: 10.1002/Chem.202000354  0.65
2020 Xu LL, Berg LJ, Jamin Keith D, Townsend SD. An effective reagent to functionalize alcohols with phosphocholine. Organic & Biomolecular Chemistry. PMID 31912847 DOI: 10.1039/C9Ob02582K  0.752
2019 Chambers SA, Townsend SD. Bioorthogonal human milk oligosaccharide probes for antimicrobial target identification within Streptococcus agalactiae. Carbohydrate Research. 488: 107895. PMID 31901817 DOI: 10.1016/J.Carres.2019.107895  0.642
2019 Craft KM, Nguyen JM, Berg LJ, Townsend SD. Methicillin-resistant (MRSA): antibiotic-resistance and the biofilm phenotype. Medchemcomm. 10: 1231-1241. PMID 31534648 DOI: 10.1039/C9Md00044E  0.773
2019 Moore RE, Townsend SD. Temporal development of the infant gut microbiome. Open Biology. 9: 190128. PMID 31506017 DOI: 10.1098/Rsob.190128  0.651
2019 Keith DJ, Townsend SD. Total Synthesis of the Congested, Bis-Phosphorylated Morganella Morganii Zwitterionic Trisaccharide Repeating Unit. Journal of the American Chemical Society. PMID 31329445 DOI: 10.1021/Jacs.9B06830  0.304
2019 Townsend SD. Human Milk Oligosaccharides: Defense Against Pathogens. Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine. 14: S5-S6. PMID 30985199 DOI: 10.1089/Bfm.2019.0039  0.38
2019 Craft KM, Townsend SD. 1-Amino-2'-fucosyllactose inhibits biofilm formation by Streptococcus agalactiae. The Journal of Antibiotics. PMID 30796331 DOI: 10.1038/S41429-019-0151-6  0.805
2019 Craft KM, Townsend SD. Mother Knows Best: Deciphering the Antibacterial Properties of Human Milk Oligosaccharides. Accounts of Chemical Research. PMID 30761895 DOI: 10.1021/Acs.Accounts.8B00630  0.816
2018 Craft KM, Thomas HC, Townsend SD. Interrogation of Human Milk Oligosaccharide Fucosylation Patterns for Antimicrobial and Antibiofilm Trends in Group B Streptococcus. Acs Infectious Diseases. PMID 30350565 DOI: 10.1021/Acsinfecdis.8B00234  0.81
2018 Craft KM, Thomas HC, Townsend SD. Sialylated variants of lacto-N-tetraose exhibit antimicrobial activity against Group B Streptococcus. Organic & Biomolecular Chemistry. PMID 30229793 DOI: 10.1039/C8Ob02080A  0.802
2018 Craft KM, Gaddy JA, Townsend SD. Human Milk Oligosaccharides Sensitize Group B Streptococcus to Clindamycin, Erythromycin, Gentamycin, and Minocycline on a Strain Specific Basis. Acs Chemical Biology. PMID 30071726 DOI: 10.1021/Acschembio.8B00661  0.796
2018 Chambers SA, DeSousa JM, Huseman ED, Townsend SD. The DARK Side of Total Synthesis: Strategies and Tactics in Psychoactive Drug Production. Acs Chemical Neuroscience. PMID 29342356 DOI: 10.1021/Acschemneuro.7B00528  0.741
2017 Ackerman DL, Craft KM, Doster RS, Weitkamp JH, Aronoff DM, Gaddy JA, Townsend SD. Antimicrobial and Antibiofilm Activity of Human Milk Oligosaccharides against Streptococcus agalactiae, Staphylococcus aureus, and Acinetobacter baumannii. Acs Infectious Diseases. PMID 29198102 DOI: 10.1021/Acsinfecdis.7B00183  0.801
2017 Craft KM, Townsend SD. The Human Milk Glycome as a Defense Against Infectious Diseases: Rationale, Challenges, and Opportunities. Acs Infectious Diseases. PMID 29140081 DOI: 10.1021/Acsinfecdis.7B00209  0.788
2017 Ackerman DL, Doster RS, Weitkamp JH, Aronoff D, Gaddy JA, Townsend SD. Human Milk Oligosaccharides Exhibit Antimicrobial and Anti-Biofilm Properties Against Group B Streptococcus. Acs Infectious Diseases. PMID 28570820 DOI: 10.1021/Acsinfecdis.7B00064  0.681
2017 Craft KM, Townsend SD. Synthesis of lacto-N-tetraose. Carbohydrate Research. 440: 43-50. PMID 28214389 DOI: 10.1016/J.Carres.2017.02.001  0.768
2016 Ackerman DL, Craft KM, Townsend SD. Infant food applications of complex carbohydrates: Structure, synthesis, and function. Carbohydrate Research. 437: 16-27. PMID 27883906 DOI: 10.1016/J.Carres.2016.11.007  0.766
2014 Townsend SD, Ross AG, Liu K, Danishefsky SJ. Stereospecific cis- and trans-ring fusions arising from common intermediates. Proceedings of the National Academy of Sciences of the United States of America. 111: 7931-5. PMID 24843125 DOI: 10.1073/Pnas.1407613111  0.653
2013 Townsend SD, Sulikowski GA. Progress toward the total synthesis of bielschowskysin. Organic Letters. 15: 5096-8. PMID 24067163 DOI: 10.1021/Ol402379M  0.668
2013 Ross AG, Townsend SD, Danishefsky SJ. Halocycloalkenones as Diels-Alder dienophiles. Applications to generating useful structural patterns. The Journal of Organic Chemistry. 78: 204-10. PMID 23151095 DOI: 10.1021/Jo302230M  0.681
2012 Li J, Dong S, Townsend SD, Dean T, Gardella TJ, Danishefsky SJ. Chemistry as an expanding resource in protein science: fully synthetic and fully active human parathyroid hormone-related protein (1-141). Angewandte Chemie (International Ed. in English). 51: 12263-7. PMID 23124999 DOI: 10.1002/Anie.201207603  0.586
2012 Wang P, Dong S, Brailsford JA, Iyer K, Townsend SD, Zhang Q, Hendrickson RC, Shieh J, Moore MA, Danishefsky SJ. At last: erythropoietin as a single glycoform. Angewandte Chemie (International Ed. in English). 51: 11576-84. PMID 23012228 DOI: 10.1002/Anie.201206090  0.722
2012 Townsend SD, Wu X, Danishefsky SJ. Enhancing the scope of the Diels-Alder reaction through isonitrile chemistry: emergence of a new class of acyl-activated dienophiles. Journal of the American Chemical Society. 134: 10659-63. PMID 22708980 DOI: 10.1021/Ja303876E  0.541
2012 Townsend SD, Tan Z, Dong S, Shang S, Brailsford JA, Danishefsky SJ. Advances in proline ligation. Journal of the American Chemical Society. 134: 3912-6. PMID 22332757 DOI: 10.1021/Ja212182Q  0.752
2012 Wang P, Dong S, Brailsford JA, Iyer K, Townsend SD, Zhang Q, Hendrickson RC, Shieh J, Moore MAS, Danishefsky SJ. Cover Picture: At Last: Erythropoietin as a Single Glycoform (Angew. Chem. Int. Ed. 46/2012) Angewandte Chemie International Edition. 51: 11391-11391. DOI: 10.1002/Anie.201208087  0.671
2012 Wang P, Dong S, Brailsford JA, Iyer K, Townsend SD, Zhang Q, Hendrickson RC, Shieh J, Moore MAS, Danishefsky SJ. Titelbild: At Last: Erythropoietin as a Single Glycoform (Angew. Chem. 46/2012) Angewandte Chemie. 124: 11555-11555. DOI: 10.1002/Ange.201208087  0.666
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