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Bjoern Schwer - Publications

Affiliations: 
Harvard Medical School - Boston Children's Hospital 
 University of California, San Francisco, San Francisco, CA 
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36 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Cheng YC, Snavely A, Barrett LB, Zhang X, Herman C, Frost DJ, Riva P, Tochitsky I, Kawaguchi R, Singh B, Ivanis J, Huebner EA, Arvanites A, Oza V, Davidow L, ... ... Schwer B, et al. Topoisomerase I inhibition and peripheral nerve injury induce DNA breaks and ATF3-associated axon regeneration in sensory neurons. Cell Reports. 36: 109666. PMID 34496254 DOI: 10.1016/j.celrep.2021.109666  0.741
2020 Dai HQ, Liang Z, Chang AN, Chapdelaine-Williams AM, Alvarado B, Pollen AA, Alt FW, Schwer B. Direct analysis of brain phenotypes via neural blastocyst complementation. Nature Protocols. PMID 32778838 DOI: 10.1038/S41596-020-0364-Y  0.756
2018 Chang AN, Liang Z, Dai HQ, Chapdelaine-Williams AM, Andrews N, Bronson RT, Schwer B, Alt FW. Neural blastocyst complementation enables mouse forebrain organogenesis. Nature. PMID 30305734 DOI: 10.1038/S41586-018-0586-0  0.764
2018 Alt FW, Schwer B. DNA double-strand breaks as drivers of neural genomic change, function, and disease. Dna Repair. PMID 30195640 DOI: 10.1016/J.Dnarep.2018.08.019  0.524
2018 Wei PC, Lee CS, Du Z, Schwer B, Zhang Y, Kao J, Zurita J, Alt FW. Three classes of recurrent DNA break clusters in brain progenitors identified by 3D proximity-based break joining assay. Proceedings of the National Academy of Sciences of the United States of America. PMID 29432181 DOI: 10.1073/Pnas.1719907115  0.571
2018 Wood JG, Schwer B, Wickremesinghe PC, Hartnett DA, Burhenn L, Garcia M, Li M, Verdin E, Helfand SL. Sirt4 is a mitochondrial regulator of metabolism and lifespan in Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America. PMID 29378963 DOI: 10.1093/Geroni/Igy023.345  0.535
2018 Schwer B, Chang AN, Liang Z, Dai H, Chapdelaine-Williams AM, Alt FW. CRISPR/Cas9-mediated genome editing in mouse embryonic stem cells and direct analysis of brain phenotypes via neural blastocyst complementation Protocol Exchange. DOI: 10.1038/Protex.2018.107  0.499
2017 Garinis GA, Schwer B, Schumacher B. Editorial: DNA Damage & Immunity. Mechanisms of Ageing and Development. PMID 28445698 DOI: 10.1016/J.Mad.2017.04.006  0.315
2016 Schwer B, Wei PC, Chang AN, Kao J, Du Z, Meyers RM, Alt FW. Transcription-associated processes cause DNA double-strand breaks and translocations in neural stem/progenitor cells. Proceedings of the National Academy of Sciences of the United States of America. 113: 2258-63. PMID 26873106 DOI: 10.1073/Pnas.1525564113  0.788
2016 Wei PC, Chang AN, Kao J, Du Z, Meyers RM, Alt FW, Schwer B. Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells. Cell. 164: 644-55. PMID 26871630 DOI: 10.1016/J.Cell.2015.12.039  0.776
2014 Gostissa M, Schwer B, Chang A, Dong J, Meyers RM, Marecki GT, Choi VW, Chiarle R, Zarrin AA, Alt FW. IgH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances. Proceedings of the National Academy of Sciences of the United States of America. 111: 2644-9. PMID 24550291 DOI: 10.1073/Pnas.1324176111  0.776
2013 Khongkow M, Olmos Y, Gong C, Gomes AR, Monteiro LJ, Yagüe E, Cavaco TB, Khongkow P, Man EP, Laohasinnarong S, Koo CY, Harada-Shoji N, Tsang JW, Coombes RC, Schwer B, et al. SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer. Carcinogenesis. 34: 1476-86. PMID 23514751 DOI: 10.1093/Carcin/Bgt098  0.314
2013 Shi W, Bain AL, Schwer B, Al-Ejeh F, Smith C, Wong L, Chai H, Miranda MS, Ho U, Kawaguchi M, Miura Y, Finnie JW, Wall M, Heierhorst J, Wicking C, et al. Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2. Plos Genetics. 9: e1003298. PMID 23408915 DOI: 10.1371/Journal.Pgen.1003298  0.591
2013 Alt FW, Zhang Y, Meng FL, Guo C, Schwer B. Mechanisms of programmed DNA lesions and genomic instability in the immune system. Cell. 152: 417-29. PMID 23374339 DOI: 10.1016/J.Cell.2013.01.007  0.526
2013 Oksenych V, Kumar V, Liu X, Guo C, Schwer B, Zha S, Alt FW. Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining. Proceedings of the National Academy of Sciences of the United States of America. 110: 2234-9. PMID 23345432 DOI: 10.1073/Pnas.1222573110  0.721
2012 Boboila C, Alt FW, Schwer B. Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks. Advances in Immunology. 116: 1-49. PMID 23063072 DOI: 10.1016/B978-0-12-394300-2.00001-6  0.767
2012 Sansó M, Lee KM, Viladevall L, Jacques PÉ, Pagé V, Nagy S, Racine A, St Amour CV, Zhang C, Shokat KM, Schwer B, Robert F, Fisher RP, Tanny JC. A positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeast. Plos Genetics. 8: e1002822. PMID 22876190 DOI: 10.1371/Journal.Pgen.1002822  0.468
2012 Boboila C, Oksenych V, Gostissa M, Wang JH, Zha S, Zhang Y, Chai H, Lee CS, Jankovic M, Saez LM, Nussenzweig MC, McKinnon PJ, Alt FW, Schwer B. Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1). Proceedings of the National Academy of Sciences of the United States of America. 109: 2473-8. PMID 22308491 DOI: 10.1073/Pnas.1121470109  0.777
2012 Oksenych V, Alt FW, Kumar V, Schwer B, Wesemann DR, Hansen E, Patel H, Su A, Guo C. Functional redundancy between repair factor XLF and damage response mediator 53BP1 in V(D)J recombination and DNA repair. Proceedings of the National Academy of Sciences of the United States of America. 109: 2455-60. PMID 22308489 DOI: 10.1073/Pnas.1121458109  0.573
2011 Hirschey MD, Shimazu T, Huang JY, Schwer B, Verdin E. SIRT3 regulates mitochondrial protein acetylation and intermediary metabolism. Cold Spring Harbor Symposia On Quantitative Biology. 76: 267-77. PMID 22114326 DOI: 10.1101/Sqb.2011.76.010850  0.551
2011 Hirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B, Stančáková A, Goetzman E, Lam MM, Schwer B, Stevens RD, Muehlbauer MJ, Kakar S, Bass NM, Kuusisto J, et al. SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Molecular Cell. 44: 177-90. PMID 21856199 DOI: 10.1016/J.Molcel.2011.07.019  0.663
2011 Ise W, Kohyama M, Schraml BU, Zhang T, Schwer B, Basu U, Alt FW, Tang J, Oltz EM, Murphy TL, Murphy KM. The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nature Immunology. 12: 536-43. PMID 21572431 DOI: 10.1038/Ni.2037  0.635
2010 Shimazu T, Hirschey MD, Hua L, Dittenhafer-Reed KE, Schwer B, Lombard DB, Li Y, Bunkenborg J, Alt FW, Denu JM, Jacobson MP, Verdin E. SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metabolism. 12: 654-61. PMID 21109197 DOI: 10.1016/J.Cmet.2010.11.003  0.638
2010 Schwer B, Schumacher B, Lombard DB, Xiao C, Kurtev MV, Gao J, Schneider JI, Chai H, Bronson RT, Tsai LH, Deng CX, Alt FW. Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity. Proceedings of the National Academy of Sciences of the United States of America. 107: 21790-4. PMID 21098266 DOI: 10.1073/Pnas.1016306107  0.536
2010 Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, et al. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 464: 121-5. PMID 20203611 DOI: 10.1038/Nature08778  0.654
2009 Schwer B, Eckersdorff M, Li Y, Silva JC, Fermin D, Kurtev MV, Giallourakis C, Comb MJ, Alt FW, Lombard DB. Calorie restriction alters mitochondrial protein acetylation. Aging Cell. 8: 604-6. PMID 19594485 DOI: 10.1111/J.1474-9726.2009.00503.X  0.48
2009 Basu U, Franklin A, Schwer B, Cheng HL, Chaudhuri J, Alt FW. Regulation of activation-induced cytidine deaminase DNA deamination activity in B-cells by Ser38 phosphorylation. Biochemical Society Transactions. 37: 561-8. PMID 19442251 DOI: 10.1042/Bst0370561  0.767
2009 Viladevall L, St Amour CV, Rosebrock A, Schneider S, Zhang C, Allen JJ, Shokat KM, Schwer B, Leatherwood JK, Fisher RP. TFIIH and P-TEFb coordinate transcription with capping enzyme recruitment at specific genes in fission yeast. Molecular Cell. 33: 738-51. PMID 19328067 DOI: 10.1016/J.Molcel.2009.01.029  0.442
2009 Cheng HL, Vuong BQ, Basu U, Franklin A, Schwer B, Astarita J, Phan RT, Datta A, Manis J, Alt FW, Chaudhuri J. Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice. Proceedings of the National Academy of Sciences of the United States of America. 106: 2717-22. PMID 19196992 DOI: 10.1073/Pnas.0812304106  0.749
2008 Schwer B, Verdin E. Conserved metabolic regulatory functions of sirtuins. Cell Metabolism. 7: 104-12. PMID 18249170 DOI: 10.1016/J.Cmet.2007.11.006  0.519
2008 Lombard DB, Schwer B, Alt FW, Mostoslavsky R. SIRT6 in DNA repair, metabolism and ageing. Journal of Internal Medicine. 263: 128-41. PMID 18226091 DOI: 10.1111/J.1365-2796.2007.01902.X  0.518
2007 Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, ... ... Schwer B, et al. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Molecular and Cellular Biology. 27: 8807-14. PMID 17923681 DOI: 10.1128/Mcb.01636-07  0.689
2007 Ahuja N, Schwer B, Carobbio S, Waltregny D, North BJ, Castronovo V, Maechler P, Verdin E. Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase. The Journal of Biological Chemistry. 282: 33583-92. PMID 17715127 DOI: 10.1074/Jbc.M705488200  0.706
2006 Schwer B, Bunkenborg J, Verdin RO, Andersen JS, Verdin E. Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. Proceedings of the National Academy of Sciences of the United States of America. 103: 10224-9. PMID 16788062 DOI: 10.1073/Pnas.0603968103  0.546
2005 North BJ, Schwer B, Ahuja N, Marshall B, Verdin E. Preparation of enzymatically active recombinant class III protein deacetylases. Methods (San Diego, Calif.). 36: 338-45. PMID 16091304 DOI: 10.1016/J.Ymeth.2005.03.004  0.715
2002 Schwer B, North BJ, Frye RA, Ott M, Verdin E. The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. The Journal of Cell Biology. 158: 647-57. PMID 12186850 DOI: 10.1083/Jcb.200205057  0.711
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