| Year |
Citation |
Score |
| 2020 |
Khaledi H, Gelb MH. Tandem Mass Spectrometry Enzyme Assays for Multiplex Detection of 10-Mucopolysaccharidoses in Dried Blood Spots and Fibroblasts. Analytical Chemistry. 92: 11721-11727. PMID 32786498 DOI: 10.1021/Acs.Analchem.0C01750 |
0.324 |
|
| 2020 |
Ogden HL, Lai Y, Nolin JD, An D, Frevert CW, Gelb MH, Altemeier WA, Hallstrand TS. Secreted Phospholipase A Group X Acts as an Adjuvant for Type 2 Inflammation, Leading to an Allergen-Specific Immune Response in the Lung. Journal of Immunology (Baltimore, Md. : 1950). PMID 32341057 DOI: 10.4049/Jimmunol.2000102 |
0.327 |
|
| 2020 |
Oguni T, Tomatsu S, Tanaka M, Orii K, Fukao T, Watanabe J, Fukuda S, Notsu Y, Vu DC, Can TBN, Nagai A, Yamaguchi S, Taketani T, Gelb MH, Kobayashi H. Validation of Liquid Chromatography-Tandem Mass Spectrometry-Based 5-Plex Assay for Mucopolysaccharidoses. International Journal of Molecular Sciences. 21. PMID 32188102 DOI: 10.3390/Ijms21062025 |
0.3 |
|
| 2019 |
Sidhu R, Mondjinou Y, Qian M, Song H, Kumar AB, Hong X, Hsu FF, Dietzen DJ, Yanjanin NM, Porter FD, Berry-Kravis E, Vite CH, Gelb MH, Schaffer JE, Ory DS, et al. N-Acyl-O-phosphocholineserines: structures of a novel class of lipids that are biomarkers for Niemann-Pick C1 disease. Journal of Lipid Research. PMID 31201291 DOI: 10.1194/Jlr.Ra119000157 |
0.307 |
|
| 2019 |
Probst A, Nguyen TN, El-Sakkary N, Skinner D, Suzuki BM, Buckner FS, Gelb MH, Caffrey CR, Debnath A. Bioactivity of Farnesyltransferase Inhibitors Against and . Frontiers in Cellular and Infection Microbiology. 9: 180. PMID 31192168 DOI: 10.3389/Fcimb.2019.00180 |
0.348 |
|
| 2018 |
Nolin JD, Murphy RC, Gelb MH, Altemeier WA, Henderson WR, Hallstrand TS. Function of secreted phospholipase A group-X in asthma and allergic disease. Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. PMID 30529275 DOI: 10.1016/J.Bbalip.2018.11.009 |
0.323 |
|
| 2018 |
Khaledi H, Liu Y, Masi S, Gelb MH. Detection of Infantile Batten Disease by Tandem Mass Spectrometry Assay of PPT1 Enzyme Activity in Dried Blood Spots. Analytical Chemistry. PMID 30204428 DOI: 10.1021/Acs.Analchem.8B03188 |
0.311 |
|
| 2018 |
Masi S, Chennamaneni N, Turecek F, Scott CR, Gelb MH. Specific Substrate for the Assay of Lysosomal Acid Lipase. Clinical Chemistry. PMID 29339442 DOI: 10.1373/Clinchem.2017.282251 |
0.328 |
|
| 2017 |
Nolin JD, Lai Y, Ogden HL, Manicone AM, Murphy RC, An D, Frevert CW, Ghomashchi F, Naika GS, Gelb MH, Gauvreau GM, Piliponsky AM, Altemeier WA, Hallstrand TS. Secreted PLA2 group X orchestrates innate and adaptive immune responses to inhaled allergen. Jci Insight. 2. PMID 29093264 DOI: 10.1172/Jci.Insight.94929 |
0.309 |
|
| 2017 |
Buchynskyy A, Gillespie JR, Herbst ZM, Ranade RM, Buckner FS, Gelb MH. 1-Benzyl-3-aryl-2-thiohydantoin Derivatives as New Anti-Trypanosoma brucei Agents: SAR and in Vivo Efficacy. Acs Medicinal Chemistry Letters. 8: 886-891. PMID 28835807 DOI: 10.1021/Acsmedchemlett.7B00230 |
0.32 |
|
| 2017 |
Silva DG, Gillespie JR, Ranade RM, Herbst ZM, Nguyen UTT, Buckner FS, Montanari CA, Gelb MH. New Class of Antitrypanosomal Agents Based on Imidazopyridines. Acs Medicinal Chemistry Letters. 8: 766-770. PMID 28740614 DOI: 10.1021/Acsmedchemlett.7B00202 |
0.315 |
|
| 2017 |
Yun B, Lee H, Powell R, Reisdorph N, Ewing H, Gelb MH, Hsu KL, Cravatt BF, Leslie CC. Regulation of calcium release from the endoplasmic reticulum by the serine hydrolase ABHD2. Biochemical and Biophysical Research Communications. PMID 28684316 DOI: 10.1016/J.Bbrc.2017.06.195 |
0.304 |
|
| 2016 |
Buchynskyy A, Gillespie JR, Hulverson MA, McQueen J, Creason SA, Ranade RM, Duster NA, Gelb MH, Buckner FS. Discovery of N-(2-aminoethyl)-N-benzyloxyphenyl benzamides: New potent Trypanosoma brucei inhibitors. Bioorganic & Medicinal Chemistry. PMID 28187957 DOI: 10.1016/J.Bmc.2016.11.019 |
0.308 |
|
| 2016 |
Ghomashchi F, Brglez V, Payré C, Jeammet L, Bezzine S, Gelb MH, Lambeau G. Preparation of the Full Set of Recombinant Mouse- and Human-Secreted Phospholipases A. Methods in Enzymology. 583: 35-69. PMID 28063498 DOI: 10.1016/Bs.Mie.2016.10.034 |
0.42 |
|
| 2016 |
Patrick DA, Gillespie JR, McQueen J, Hulverson MA, Ranade RM, Creason SA, Herbst ZM, Gelb MH, Buckner FS, Tidwell RR. Urea Derivatives of 2-Aryl-benzothiazol-5-amines: A New Class of Potential Drugs for Human African Trypanosomiasis. Journal of Medicinal Chemistry. PMID 27992217 DOI: 10.1021/Acs.Jmedchem.6B01163 |
0.315 |
|
| 2016 |
Zhang Z, Koh CY, Ranade RM, Shibata S, Gillespie JR, Hulverson MA, Huang W, Nguyen J, Pendem N, Gelb MH, Verlinde CL, Hol WG, Buckner FS, Fan E. 5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors. Acs Infectious Diseases. 2: 399-404. PMID 27627628 DOI: 10.1021/Acsinfecdis.6B00036 |
0.323 |
|
| 2016 |
Yun B, Lee H, Ewing H, Gelb MH, Leslie CC. Off-target effect of the cPLA2α inhibitor pyrrophenone: Inhibition of calcium release from the endoplasmic reticulum. Biochemical and Biophysical Research Communications. PMID 27620490 DOI: 10.1016/J.Bbrc.2016.09.033 |
0.305 |
|
| 2016 |
Nolin JD, Ogden HL, Lai Y, Altemeier WA, Frevert CW, Bollinger JG, Naika GS, Kicic A, Stick SM, Lambeau G, Henderson WR, Gelb MH, Hallstrand TS. Identification of Epithelial Phospholipase A2 Receptor 1 (PLA2R1) as a Potential Target in Asthma. American Journal of Respiratory Cell and Molecular Biology. PMID 27448109 DOI: 10.1165/Rcmb.2015-0150Oc |
0.59 |
|
| 2016 |
Schewe M, Franken PF, Sacchetti A, Schmitt M, Joosten R, Böttcher R, van Royen ME, Jeammet L, Payré C, Scott PM, Webb NR, Gelb M, Cormier RT, Lambeau G, Fodde R. Secreted Phospholipases A2 Are Intestinal Stem Cell Niche Factors with Distinct Roles in Homeostasis, Inflammation, and Cancer. Cell Stem Cell. PMID 27292189 DOI: 10.1016/J.Stem.2016.05.023 |
0.3 |
|
| 2016 |
Miki Y, Kidoguchi Y, Sato M, Taketomi Y, Taya C, Muramatsu K, Gelb MH, Yamamoto K, Murakami M. Dual roles of group IID phospholipase A2 in inflammation and cancer. The Journal of Biological Chemistry. PMID 27226632 DOI: 10.1074/Jbc.M116.734624 |
0.301 |
|
| 2016 |
Ewing H, Fernández-Vega V, Spicer TP, Chase P, Brown S, Scampavia L, Roush WR, Riley S, Rosen H, Hodder P, Lambeau G, Gelb MH. Fluorometric High-Throughput Screening Assay for Secreted Phospholipases A2 Using Phospholipid Vesicles. Journal of Biomolecular Screening. PMID 27146384 DOI: 10.1177/1087057116646742 |
0.375 |
|
| 2016 |
Vasilakaki S, Barbayianni E, Leonis G, Papadopoulos MG, Mavromoustakos T, Gelb MH, Kokotos G. Development of a potent 2-oxoamide inhibitor of secreted phospholipase A2 guided by molecular docking calculations and molecular dynamics simulations. Bioorganic & Medicinal Chemistry. PMID 26970660 DOI: 10.1016/J.Bmc.2016.02.040 |
0.363 |
|
| 2015 |
Yamamoto K, Miki Y, Sato M, Taketomi Y, Nishito Y, Taya C, Muramatsu K, Ikeda K, Nakanishi H, Taguchi R, Kambe N, Kabashima K, Lambeau G, Gelb MH, Murakami M. The role of group IIF-secreted phospholipase A2 in epidermal homeostasis and hyperplasia. The Journal of Experimental Medicine. 212: 1901-19. PMID 26438362 DOI: 10.1084/Jem.20141904 |
0.314 |
|
| 2015 |
Kumar AB, Spacil Z, Ghomashchi F, Masi S, Sumida T, Ito M, Turecek F, Scott CR, Gelb MH. Fluorimetric assays for N-acetylgalactosamine-6-sulfatase and arylsulfatase B based on the natural substrates for confirmation of mucopolysaccharidoses types IVA and VI. Clinica Chimica Acta; International Journal of Clinical Chemistry. PMID 26282597 DOI: 10.1016/J.Cca.2015.08.010 |
0.344 |
|
| 2015 |
Hallstrand TS, Lai Y, Hooper KA, Oslund RC, Altemeier WA, Matute-Bello G, Gelb MH. Endogenous secreted phospholipase A2 group X regulates cysteinyl leukotrienes synthesis by human eosinophils. The Journal of Allergy and Clinical Immunology. PMID 26139511 DOI: 10.1016/J.Jaci.2015.05.026 |
0.712 |
|
| 2015 |
Duchez AC, Boudreau LH, Bollinger J, Belleannée C, Cloutier N, Laffont B, Mendoza-Villarroel RE, Lévesque T, Rollet-Labelle E, Rousseau M, Allaeys I, Tremblay JJ, Poubelle PE, Lambeau G, Pouliot M, ... ... Gelb MH, et al. Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA. Proceedings of the National Academy of Sciences of the United States of America. PMID 26106157 DOI: 10.1073/Pnas.1507905112 |
0.621 |
|
| 2015 |
Rousseau M, Naika GS, Perron J, Jacques F, Gelb MH, Boilard E. Study of the role of cytosolic phospholipase A2 alpha in eicosanoid generation and thymocyte maturation in the thymus. Plos One. 10: e0126204. PMID 25969996 DOI: 10.1371/Journal.Pone.0126204 |
0.336 |
|
| 2015 |
Guillaume C, Payré C, Jemel I, Jeammet L, Bezzine S, Naika GS, Bollinger J, Grellier P, Gelb MH, Schrével J, Lambeau G, Deregnaucourt C. In vitro anti-Plasmodium falciparum properties of the full set of human secreted phospholipases A2. Infection and Immunity. 83: 2453-65. PMID 25824843 DOI: 10.1128/Iai.02474-14 |
0.647 |
|
| 2015 |
Ghomashchi F, Barcenas M, Turecek F, Scott CR, Gelb MH. Reliable Assay of Acid Sphingomyelinase Deficiency with the Mutation Q292K by Tandem Mass Spectrometry. Clinical Chemistry. 61: 771-2. PMID 25770139 DOI: 10.1373/Clinchem.2014.236448 |
0.314 |
|
| 2015 |
Rousseau M, Belleannee C, Duchez AC, Cloutier N, Levesque T, Jacques F, Perron J, Nigrovic PA, Dieude M, Hebert MJ, Gelb MH, Boilard E. Detection and quantification of microparticles from different cellular lineages using flow cytometry. Evaluation of the impact of secreted phospholipase A2 on microparticle assessment. Plos One. 10: e0116812. PMID 25587983 DOI: 10.1371/Journal.Pone.0116812 |
0.356 |
|
| 2014 |
Boudreau LH, Duchez AC, Cloutier N, Soulet D, Martin N, Bollinger J, Paré A, Rousseau M, Naika GS, Lévesque T, Laflamme C, Marcoux G, Lambeau G, Farndale RW, Pouliot M, ... ... Gelb MH, et al. Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation. Blood. 124: 2173-83. PMID 25082876 DOI: 10.1182/Blood-2014-05-573543 |
0.624 |
|
| 2014 |
Barcenas M, Xue C, Marushchak-Vlaskin T, Scott CR, Gelb MH, Ture?ek F. Tandem mass spectrometry assays of palmitoyl protein thioesterase 1 and tripeptidyl peptidase activity in dried blood spots for the detection of neuronal ceroid lipofuscinoses in newborns. Analytical Chemistry. 86: 7962-8. PMID 25019629 DOI: 10.1021/Ac501994B |
0.329 |
|
| 2014 |
Kelvin AA, Degousee N, Banner D, Stefanski E, Le?n AJ, Angoulvant D, Paquette SG, Huang SS, Danesh A, Robbins CS, Noyan H, Husain M, Lambeau G, Gelb M, Kelvin DJ, et al. Lack of group X secreted phospholipase A₂ increases survival following pandemic H1N1 influenza infection. Virology. 454: 78-92. PMID 24725934 DOI: 10.1016/J.Virol.2014.01.030 |
0.301 |
|
| 2014 |
Chennamaneni NK, Kumar AB, Barcenas M, Spá?il Z, Scott CR, Ture?ek F, Gelb MH. Improved reagents for newborn screening of mucopolysaccharidosis types I, II, and VI by tandem mass spectrometry. Analytical Chemistry. 86: 4508-14. PMID 24694010 DOI: 10.1021/Ac5004135 |
0.344 |
|
| 2014 |
Tatipaka HB, Gillespie JR, Chatterjee AK, Norcross NR, Hulverson MA, Ranade RM, Nagendar P, Creason SA, McQueen J, Duster NA, Nagle A, Supek F, Molteni V, Wenzler T, Brun R, ... ... Gelb MH, et al. Substituted 2-phenylimidazopyridines: a new class of drug leads for human African trypanosomiasis. Journal of Medicinal Chemistry. 57: 828-35. PMID 24354316 DOI: 10.1021/Jm401178T |
0.306 |
|
| 2014 |
Yun B, Lee H, Ghosh M, Cravatt BF, Hsu KL, Bonventre JV, Ewing H, Gelb MH, Leslie CC. Serine hydrolase inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation. The Journal of Biological Chemistry. 289: 1491-504. PMID 24297180 DOI: 10.1074/Jbc.M113.497651 |
0.313 |
|
| 2014 |
Hallstrand TS, Lai Y, Hooper KA, Oslund RC, Altemeier WA, Matute-Bello G, Gelb MH. Endogenous secreted phospholipase A2 group X regulates cysteinyl leukotrienes synthesis by human eosinophils Journal of Allergy and Clinical Immunology. DOI: 10.1016/j.jaci.2015.05.026 |
0.681 |
|
| 2013 |
Suryadevara PK, Racherla KK, Olepu S, Norcross NR, Tatipaka HB, Arif JA, Planer JD, Lepesheva GI, Verlinde CL, Buckner FS, Gelb MH. Dialkylimidazole inhibitors of Trypanosoma cruzi sterol 14α-demethylase as anti-Chagas disease agents. Bioorganic & Medicinal Chemistry Letters. 23: 6492-9. PMID 24120539 DOI: 10.1016/J.Bmcl.2013.08.015 |
0.321 |
|
| 2013 |
Bollinger JG, Naika GS, Rohan G, Sadilek M, Gelb MH. LC/ESI-MS/MS detection of FAs by charge reversal derivatization with more than four orders of magnitude improvement in sensitivity. Journal of Lipid Research. 54: 3523-30. PMID 23945566 DOI: 10.1194/Jlr.D040782 |
0.597 |
|
| 2013 |
Miki Y, Yamamoto K, Taketomi Y, Sato H, Shimo K, Kobayashi T, Ishikawa Y, Ishii T, Nakanishi H, Ikeda K, Taguchi R, Kabashima K, Arita M, Arai H, Lambeau G, ... ... Gelb MH, et al. Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators. The Journal of Experimental Medicine. 210: 1217-34. PMID 23690440 DOI: 10.1084/Jem.20121887 |
0.326 |
|
| 2013 |
Hallstrand TS, Lai Y, Altemeier WA, Appel CL, Johnson B, Frevert CW, Hudkins KL, Bollinger JG, Woodruff PG, Hyde DM, Henderson WR, Gelb MH. Regulation and function of epithelial secreted phospholipase A2 group X in asthma. American Journal of Respiratory and Critical Care Medicine. 188: 42-50. PMID 23614662 DOI: 10.1164/Rccm.201301-0084Oc |
0.622 |
|
| 2013 |
Lee LK, Bryant KJ, Bouveret R, Lei PW, Duff AP, Harrop SJ, Huang EP, Harvey RP, Gelb MH, Gray PP, Curmi PM, Cunningham AM, Church WB, Scott KF. Selective inhibition of human group IIA-secreted phospholipase A2 (hGIIA) signaling reveals arachidonic acid metabolism is associated with colocalization of hGIIA to vimentin in rheumatoid synoviocytes. The Journal of Biological Chemistry. 288: 15269-79. PMID 23482564 DOI: 10.1074/Jbc.M112.397893 |
0.373 |
|
| 2013 |
Henderson WR, Ye X, Lai Y, Ni Z, Bollinger JG, Tien YT, Chi EY, Gelb MH. Key role of group v secreted phospholipase A2 in Th2 cytokine and dendritic cell-driven airway hyperresponsiveness and remodeling. Plos One. 8: e56172. PMID 23451035 DOI: 10.1371/Journal.Pone.0056172 |
0.621 |
|
| 2012 |
Oslund RC, Gelb MH. Biochemical characterization of selective inhibitors of human group IIA secreted phospholipase A(2) and hyaluronic acid-linked inhibitor conjugates. Biochemistry. 51: 8617-26. PMID 23020658 DOI: 10.1021/Bi301140B |
0.728 |
|
| 2012 |
Pérez-Moreno G, Sealey-Cardona M, Rodrigues-Poveda C, Gelb MH, Ruiz-Pérez LM, Castillo-Acosta V, Urbina JA, González-Pacanowska D. Endogenous sterol biosynthesis is important for mitochondrial function and cell morphology in procyclic forms of Trypanosoma brucei. International Journal For Parasitology. 42: 975-89. PMID 22964455 DOI: 10.1016/J.Ijpara.2012.07.012 |
0.315 |
|
| 2012 |
Buckner FS, Bahia MT, Suryadevara PK, White KL, Shackleford DM, Chennamaneni NK, Hulverson MA, Laydbak JU, Chatelain E, Scandale I, Verlinde CL, Charman SA, Lepesheva GI, Gelb MH. Pharmacological characterization, structural studies, and in vivo activities of anti-Chagas disease lead compounds derived from tipifarnib. Antimicrobial Agents and Chemotherapy. 56: 4914-21. PMID 22777048 DOI: 10.1128/Aac.06244-11 |
0.347 |
|
| 2012 |
Thompson W, Oslund RC, Bollinger J, Ewing H, Gelb MH. High-throughput assay of secreted phospholipases Aâ‚‚ inhibitors. Methods in Molecular Biology (Clifton, N.J.). 861: 149-58. PMID 22426718 DOI: 10.1007/978-1-61779-600-5_10 |
0.789 |
|
| 2012 |
Aloulou A, Ali YB, Bezzine S, Gargouri Y, Gelb MH. Phospholipases: an overview. Methods in Molecular Biology (Clifton, N.J.). 861: 63-85. PMID 22426712 DOI: 10.1007/978-1-61779-600-5_4 |
0.324 |
|
| 2012 |
Wolfe BJ, Ghomashchi F, Kim T, Abam CA, Sadilek M, Jack R, Thompson JN, Scott CR, Gelb MH, Turecek F. New substrates and enzyme assays for the detection of mucopolysaccharidosis III (Sanfilippo Syndrome) types A, B, C, and D by tandem mass spectrometry. Bioconjugate Chemistry. 23: 557-64. PMID 22372747 DOI: 10.1021/Bc200609X |
0.34 |
|
| 2012 |
Jain MK, Yu BZ, Gelb MH, Berg OG. Assay of phospholipases A(2) and their inhibitors by kinetic analysis in the scooting mode. Mediators of Inflammation. 1: 85-100. PMID 18475447 DOI: 10.1155/S0962935192000164 |
0.342 |
|
| 2011 |
Jemel I, Ii H, Oslund RC, Payré C, Dabert-Gay AS, Douguet D, Chargui K, Scarzello S, Gelb MH, Lambeau G. Group X secreted phospholipase A2 proenzyme is matured by a furin-like proprotein convertase and releases arachidonic acid inside of human HEK293 cells. The Journal of Biological Chemistry. 286: 36509-21. PMID 21878635 DOI: 10.1074/Jbc.M111.268540 |
0.719 |
|
| 2011 |
Degousee N, Kelvin DJ, Geisslinger G, Hwang DM, Stefanski E, Wang XH, Danesh A, Angioni C, Schmidt H, Lindsay TF, Gelb MH, Bollinger J, Payré C, Lambeau G, Arm JP, et al. Group V phospholipase A2 in bone marrow-derived myeloid cells and bronchial epithelial cells promotes bacterial clearance after Escherichia coli pneumonia. The Journal of Biological Chemistry. 286: 35650-62. PMID 21849511 DOI: 10.1074/Jbc.M111.262733 |
0.593 |
|
| 2011 |
Henderson WR, Oslund RC, Bollinger JG, Ye X, Tien YT, Xue J, Gelb MH. Blockade of human group X secreted phospholipase A2 (GX-sPLA2)-induced airway inflammation and hyperresponsiveness in a mouse asthma model by a selective GX-sPLA2 inhibitor. The Journal of Biological Chemistry. 286: 28049-55. PMID 21652694 DOI: 10.1074/Jbc.M111.235812 |
0.775 |
|
| 2011 |
Shridas P, Bailey WM, Talbott KR, Oslund RC, Gelb MH, Webb NR. Group X secretory phospholipase A2 enhances TLR4 signaling in macrophages. Journal of Immunology (Baltimore, Md. : 1950). 187: 482-9. PMID 21622863 DOI: 10.4049/Jimmunol.1003552 |
0.701 |
|
| 2011 |
Hallstrand TS, Lai Y, Ni Z, Oslund RC, Henderson WR, Gelb MH, Wenzel SE. Relationship between levels of secreted phospholipase A₂ groups IIA and X in the airways and asthma severity. Clinical and Experimental Allergy : Journal of the British Society For Allergy and Clinical Immunology. 41: 801-10. PMID 21255140 DOI: 10.1111/J.1365-2222.2010.03676.X |
0.689 |
|
| 2011 |
Reed KA, Tucker DE, Aloulou A, Adler D, Ghomashchi F, Gelb MH, Leslie CC, Oates JA, Boutaud O. Functional characterization of mutations in inherited human cPLA₂ deficiency. Biochemistry. 50: 1731-8. PMID 21247147 DOI: 10.1021/Bi101877N |
0.329 |
|
| 2011 |
Mouchlis VD, Magrioti V, Barbayianni E, Cermak N, Oslund RC, Mavromoustakos TM, Gelb MH, Kokotos G. Inhibition of secreted phospholipases A₂ by 2-oxoamides based on α-amino acids: Synthesis, in vitro evaluation and molecular docking calculations. Bioorganic & Medicinal Chemistry. 19: 735-43. PMID 21216150 DOI: 10.1016/J.Bmc.2010.12.030 |
0.718 |
|
| 2011 |
Wolfe BJ, Blanchard S, Sadilek M, Scott CR, Turecek F, Gelb MH. Tandem mass spectrometry for the direct assay of lysosomal enzymes in dried blood spots: application to screening newborns for mucopolysaccharidosis II (Hunter Syndrome). Analytical Chemistry. 83: 1152-6. PMID 21192662 DOI: 10.1021/Ac102777S |
0.314 |
|
| 2011 |
Bryant KJ, Bidgood MJ, Lei PW, Taberner M, Salom C, Kumar V, Lee L, Church WB, Courtenay B, Smart BP, Gelb MH, Cahill MA, Graham GG, McNeil HP, Scott KF. A bifunctional role for group IIA secreted phospholipase A2 in human rheumatoid fibroblast-like synoviocyte arachidonic acid metabolism. The Journal of Biological Chemistry. 286: 2492-503. PMID 21068383 DOI: 10.1074/Jbc.M110.123927 |
0.776 |
|
| 2011 |
Khaliq T, Sadilek M, Scott CR, Turecek F, Gelb MH. Tandem mass spectrometry for the direct assay of lysosomal enzymes in dried blood spots: application to screening newborns for mucopolysaccharidosis IVA. Clinical Chemistry. 57: 128-31. PMID 21030685 DOI: 10.1373/Clinchem.2010.149880 |
0.336 |
|
| 2011 |
Crowther GJ, Napuli AJ, Gilligan JH, Gagaring K, Borboa R, Francek C, Chen Z, Dagostino EF, Stockmyer JB, Wang Y, Rodenbough PP, Castaneda LJ, Leibly DJ, Bhandari J, Gelb MH, et al. Identification of inhibitors for putative malaria drug targets among novel antimalarial compounds. Molecular and Biochemical Parasitology. 175: 21-9. PMID 20813141 DOI: 10.1016/J.Molbiopara.2010.08.005 |
0.325 |
|
| 2011 |
Ghomashchi F, Stewart A, Hefner Y, Ramanadham S, Turk J, Leslie CC, Gelb MH. Corrigendum to “A pyrrolidine-based specific inhibitor of cytosolic phospholipase A2α blocks arachidonic acid release in a variety of mammalian cells.” [Biochem. Biophys. Acta 1513 (2001) 160–166] Biochimica Et Biophysica Acta (Bba) - Biomembranes. 1808: 1779. DOI: 10.1016/J.Bbamem.2010.11.018 |
0.328 |
|
| 2010 |
Lai Y, Oslund RC, Bollinger JG, Henderson WR, Santana LF, Altemeier WA, Gelb MH, Hallstrand TS. Eosinophil cysteinyl leukotriene synthesis mediated by exogenous secreted phospholipase A2 group X. The Journal of Biological Chemistry. 285: 41491-500. PMID 20974857 DOI: 10.1074/Jbc.M110.153338 |
0.783 |
|
| 2010 |
Duffey TA, Sadilek M, Scott CR, Turecek F, Gelb MH. Tandem mass spectrometry for the direct assay of lysosomal enzymes in dried blood spots: application to screening newborns for mucopolysaccharidosis VI (Maroteaux-Lamy syndrome). Analytical Chemistry. 82: 9587-91. PMID 20961069 DOI: 10.1021/Ac102090V |
0.325 |
|
| 2010 |
Duffey TA, Bellamy G, Elliott S, Fox AC, Glass M, Turecek F, Gelb MH, Scott CR. A tandem mass spectrometry triplex assay for the detection of Fabry, Pompe, and mucopolysaccharidosis-I (Hurler). Clinical Chemistry. 56: 1854-61. PMID 20940330 DOI: 10.1373/Clinchem.2010.152009 |
0.311 |
|
| 2010 |
Shridas P, Bailey WM, Gizard F, Oslund RC, Gelb MH, Bruemmer D, Webb NR. Group X secretory phospholipase A2 negatively regulates ABCA1 and ABCG1 expression and cholesterol efflux in macrophages. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 2014-21. PMID 20844270 DOI: 10.1161/Atvbaha.110.210237 |
0.709 |
|
| 2010 |
Duffey TA, Khaliq T, Scott CR, Turecek F, Gelb MH. Design and synthesis of substrates for newborn screening of Maroteaux-Lamy and Morquio A syndromes. Bioorganic & Medicinal Chemistry Letters. 20: 5994-6. PMID 20833037 DOI: 10.1016/J.Bmcl.2010.08.080 |
0.337 |
|
| 2010 |
Fletcher S, Keaney EP, Cummings CG, Blaskovich MA, Hast MA, Glenn MP, Chang SY, Bucher CJ, Floyd RJ, Katt WP, Gelb MH, Van Voorhis WC, Beese LS, Sebti SM, Hamilton AD. Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents. Journal of Medicinal Chemistry. 53: 6867-88. PMID 20822181 DOI: 10.1021/Jm1001748 |
0.377 |
|
| 2010 |
Ghomashchi F, Naika GS, Bollinger JG, Aloulou A, Lehr M, Leslie CC, Gelb MH. Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms. The Journal of Biological Chemistry. 285: 36100-11. PMID 20705608 DOI: 10.1074/Jbc.M110.165647 |
0.643 |
|
| 2010 |
Bollinger JG, Thompson W, Lai Y, Oslund RC, Hallstrand TS, Sadilek M, Turecek F, Gelb MH. Improved sensitivity mass spectrometric detection of eicosanoids by charge reversal derivatization. Analytical Chemistry. 82: 6790-6. PMID 20704368 DOI: 10.1021/Ac100720P |
0.76 |
|
| 2010 |
Choiniere JR, Scott CR, Gelb MH, Turecek F. Direct assay of delta-aminolevulinic acid dehydratase in heme biosynthesis for the detection of porphyrias by tandem mass spectrometry. Analytical Chemistry. 82: 6730-6. PMID 20583792 DOI: 10.1021/Ac101111M |
0.352 |
|
| 2010 |
Boilard E, Lai Y, Larabee K, Balestrieri B, Ghomashchi F, Fujioka D, Gobezie R, Coblyn JS, Weinblatt ME, Massarotti EM, Thornhill TS, Divangahi M, Remold H, Lambeau G, Gelb MH, et al. A novel anti-inflammatory role for secretory phospholipase A2 in immune complex-mediated arthritis. Embo Molecular Medicine. 2: 172-87. PMID 20432503 DOI: 10.1002/Emmm.201000072 |
0.331 |
|
| 2010 |
Kraus JM, Tatipaka HB, McGuffin SA, Chennamaneni NK, Karimi M, Arif J, Verlinde CL, Buckner FS, Gelb MH. Second generation analogues of the cancer drug clinical candidate tipifarnib for anti-Chagas disease drug discovery. Journal of Medicinal Chemistry. 53: 3887-98. PMID 20429511 DOI: 10.1021/Jm9013136 |
0.367 |
|
| 2010 |
Shridas P, Bailey WM, Boyanovsky BB, Oslund RC, Gelb MH, Webb NR. Group X secretory phospholipase A2 regulates the expression of steroidogenic acute regulatory protein (StAR) in mouse adrenal glands. The Journal of Biological Chemistry. 285: 20031-9. PMID 20421306 DOI: 10.1074/Jbc.M109.090423 |
0.697 |
|
| 2010 |
Granata F, Frattini A, Loffredo S, Staiano RI, Petraroli A, Ribatti D, Oslund R, Gelb MH, Lambeau G, Marone G, Triggiani M. Production of vascular endothelial growth factors from human lung macrophages induced by group IIA and group X secreted phospholipases A2. Journal of Immunology (Baltimore, Md. : 1950). 184: 5232-41. PMID 20357262 DOI: 10.4049/Jimmunol.0902501 |
0.699 |
|
| 2010 |
Olson ED, Nelson J, Griffith K, Nguyen T, Streeter M, Wilson-Ashworth HA, Gelb MH, Judd AM, Bell JD. Kinetic evaluation of cell membrane hydrolysis during apoptosis by human isoforms of secretory phospholipase A2. The Journal of Biological Chemistry. 285: 10993-1002. PMID 20139082 DOI: 10.1074/Jbc.M109.070797 |
0.322 |
|
| 2010 |
Zhang XK, Elbin CS, Turecek F, Scott R, Chuang WL, Keutzer JM, Gelb M. Multiplex lysosomal enzyme activity assay on dried blood spots using tandem mass spectrometry. Methods in Molecular Biology (Clifton, N.J.). 603: 339-50. PMID 20077085 DOI: 10.1007/978-1-60761-459-3_32 |
0.333 |
|
| 2010 |
Crowther GJ, He P, Rodenbough PP, Thomas AP, Kovzun KV, Leibly DJ, Bhandari J, Castaneda LJ, Hol WG, Gelb MH, Napuli AJ, Van Voorhis WC. Use of thermal melt curves to assess the quality of enzyme preparations. Analytical Biochemistry. 399: 268-75. PMID 20018159 DOI: 10.1016/J.Ab.2009.12.018 |
0.31 |
|
| 2010 |
Bollinger JG, Ii H, Sadilek M, Gelb MH. Improved method for the quantification of lysophospholipids including enol ether species by liquid chromatography-tandem mass spectrometry. Journal of Lipid Research. 51: 440-7. PMID 19717841 DOI: 10.1194/Jlr.D000885 |
0.621 |
|
| 2009 |
Surrel F, Jemel I, Boilard E, Bollinger JG, Payré C, Mounier CM, Talvinen KA, Laine VJ, Nevalainen TJ, Gelb MH, Lambeau G. Group X phospholipase A2 stimulates the proliferation of colon cancer cells by producing various lipid mediators. Molecular Pharmacology. 76: 778-90. PMID 19602573 DOI: 10.1124/Mol.108.053371 |
0.672 |
|
| 2009 |
Triggiani M, Giannattasio G, Calabrese C, Loffredo S, Granata F, Fiorello A, Santini M, Gelb MH, Marone G. Lung mast cells are a source of secreted phospholipases A2. The Journal of Allergy and Clinical Immunology. 124: 558-65, 565.e1-3. PMID 19541351 DOI: 10.1016/J.Jaci.2009.04.035 |
0.366 |
|
| 2009 |
Suryadevara PK, Olepu S, Lockman JW, Ohkanda J, Karimi M, Verlinde CL, Kraus JM, Schoepe J, Van Voorhis WC, Hamilton AD, Buckner FS, Gelb MH. Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease. Journal of Medicinal Chemistry. 52: 3703-15. PMID 19463001 DOI: 10.1021/Jm900030H |
0.325 |
|
| 2009 |
Hast MA, Fletcher S, Cummings CG, Pusateri EE, Blaskovich MA, Rivas K, Gelb MH, Van Voorhis WC, Sebti SM, Hamilton AD, Beese LS. Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase. Chemistry & Biology. 16: 181-92. PMID 19246009 DOI: 10.1016/J.Chembiol.2009.01.014 |
0.375 |
|
| 2009 |
Kraus JM, Verlinde CL, Karimi M, Lepesheva GI, Gelb MH, Buckner FS. Rational modification of a candidate cancer drug for use against Chagas disease. Journal of Medicinal Chemistry. 52: 1639-47. PMID 19239254 DOI: 10.1021/Jm801313T |
0.304 |
|
| 2009 |
Torres-Santos EC, Sampaio-Santos MI, Buckner FS, Yokoyama K, Gelb M, Urbina JA, Rossi-Bergmann B. Altered sterol profile induced in Leishmania amazonensis by a natural dihydroxymethoxylated chalcone. The Journal of Antimicrobial Chemotherapy. 63: 469-72. PMID 19176591 DOI: 10.1093/Jac/Dkn546 |
0.301 |
|
| 2009 |
Tucker DE, Ghosh M, Ghomashchi F, Loper R, Suram S, John BS, Girotti M, Bollinger JG, Gelb MH, Leslie CC. Role of phosphorylation and basic residues in the catalytic domain of cytosolic phospholipase A2alpha in regulating interfacial kinetics and binding and cellular function. The Journal of Biological Chemistry. 284: 9596-611. PMID 19176526 DOI: 10.1074/Jbc.M807299200 |
0.614 |
|
| 2009 |
Giannattasio G, Lai Y, Granata F, Mounier CM, Nallan L, Oslund R, Leslie CC, Marone G, Lambeau G, Gelb MH, Triggiani M. Expression of phospholipases A2 in primary human lung macrophages: role of cytosolic phospholipase A2-alpha in arachidonic acid release and platelet activating factor synthesis. Biochimica Et Biophysica Acta. 1791: 92-102. PMID 19130898 DOI: 10.1016/J.Bbalip.2008.12.002 |
0.725 |
|
| 2009 |
Su W, Yeku O, Olepu S, Genna A, Park JS, Ren H, Du G, Gelb MH, Morris AJ, Frohman MA. 5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. Molecular Pharmacology. 75: 437-46. PMID 19064628 DOI: 10.1124/Mol.108.053298 |
0.348 |
|
| 2008 |
Blanchard S, Sadilek M, Scott CR, Turecek F, Gelb MH. Tandem mass spectrometry for the direct assay of lysosomal enzymes in dried blood spots: application to screening newborns for mucopolysaccharidosis I. Clinical Chemistry. 54: 2067-70. PMID 19042989 DOI: 10.1373/Clinchem.2008.115410 |
0.333 |
|
| 2008 |
Oslund RC, Cermak N, Verlinde CL, Gelb MH. Simplified YM-26734 inhibitors of secreted phospholipase A2 group IIA. Bioorganic & Medicinal Chemistry Letters. 18: 5415-9. PMID 18818074 DOI: 10.1016/J.Bmcl.2008.09.041 |
0.722 |
|
| 2008 |
Wilensky RL, Shi Y, Mohler ER, Hamamdzic D, Burgert ME, Li J, Postle A, Fenning RS, Bollinger JG, Hoffman BE, Pelchovitz DJ, Yang J, Mirabile RC, Webb CL, Zhang L, ... ... Gelb MH, et al. Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development. Nature Medicine. 14: 1059-66. PMID 18806801 DOI: 10.1038/Nm.1870 |
0.602 |
|
| 2008 |
Fletcher S, Cummings CG, Rivas K, Katt WP, Hornéy C, Buckner FS, Chakrabarti D, Sebti SM, Gelb MH, Van Voorhis WC, Hamilton AD. Potent, Plasmodium-selective farnesyltransferase inhibitors that arrest the growth of malaria parasites: structure-activity relationships of ethylenediamine-analogue scaffolds and homology model validation. Journal of Medicinal Chemistry. 51: 5176-97. PMID 18686940 DOI: 10.1021/Jm800113P |
0.385 |
|
| 2008 |
Ojo KK, Gillespie JR, Riechers AJ, Napuli AJ, Verlinde CL, Buckner FS, Gelb MH, Domostoj MM, Wells SJ, Scheer A, Wells TN, Van Voorhis WC. Glycogen synthase kinase 3 is a potential drug target for African trypanosomiasis therapy. Antimicrobial Agents and Chemotherapy. 52: 3710-7. PMID 18644955 DOI: 10.1128/Aac.00364-08 |
0.33 |
|
| 2008 |
Oslund RC, Cermak N, Gelb MH. Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2. Journal of Medicinal Chemistry. 51: 4708-14. PMID 18605714 DOI: 10.1021/Jm800422V |
0.735 |
|
| 2008 |
Tucker DE, Gijón MA, Spencer DM, Qiu ZH, Gelb MH, Leslie CC. Regulation of cytosolic phospholipase A2alpha by hsp90 and a p54 kinase in okadaic acid-stimulated macrophages. Journal of Leukocyte Biology. 84: 798-806. PMID 18550790 DOI: 10.1189/Jlb.0308197 |
0.311 |
|
| 2008 |
Lambeau G, Gelb MH. Biochemistry and physiology of mammalian secreted phospholipases A2. Annual Review of Biochemistry. 77: 495-520. PMID 18405237 DOI: 10.1146/Annurev.Biochem.76.062405.154007 |
0.384 |
|
| 2008 |
Wang Y, Scott CR, Gelb MH, Turecek F. Direct assay of enzymes in heme biosynthesis for the detection of porphyrias by tandem mass spectrometry. Porphobilinogen deaminase. Analytical Chemistry. 80: 2606-11. PMID 18294005 DOI: 10.1021/Ac702244X |
0.346 |
|
| 2008 |
Wang Y, Gatti P, Sadílek M, Scott CR, Turecek F, Gelb MH. Direct assay of enzymes in heme biosynthesis for the detection of porphyrias by tandem mass spectrometry. Uroporphyrinogen decarboxylase and coproporphyrinogen III oxidase. Analytical Chemistry. 80: 2599-605. PMID 18294003 DOI: 10.1021/Ac702130N |
0.335 |
|
| 2008 |
Bulbule VJ, Rivas K, Verlinde CL, Van Voorhis WC, Gelb MH. 2-Oxotetrahydroquinoline-based antimalarials with high potency and metabolic stability. Journal of Medicinal Chemistry. 51: 384-7. PMID 18198825 DOI: 10.1021/Jm7013138 |
0.307 |
|
| 2008 |
Olepu S, Suryadevara PK, Rivas K, Yokoyama K, Verlinde CL, Chakrabarti D, Van Voorhis WC, Gelb MH. 2-Oxo-tetrahydro-1,8-naphthyridines as selective inhibitors of malarial protein farnesyltransferase and as anti-malarials. Bioorganic & Medicinal Chemistry Letters. 18: 494-7. PMID 18077162 DOI: 10.1016/J.Bmcl.2007.11.104 |
0.324 |
|
| 2008 |
Yokoyama K, Gillespie JR, Van Voorhis WC, Buckner FS, Gelb MH. Protein geranylgeranyltransferase-I of Trypanosoma cruzi. Molecular and Biochemical Parasitology. 157: 32-43. PMID 17996962 DOI: 10.1016/J.Molbiopara.2007.09.006 |
0.322 |
|
| 2007 |
Ghomashchi F, Bollinger JG, Gelb MH. Facile preparation of leukotrienes C(4), D(4) and E(4) containing carbon-13 and nitrogen-15 for quantification of cysteinyl leukotrienes by mass spectrometry. Journal of Labelled Compounds & Radiopharmaceuticals. 50: 729-733. PMID 18516250 DOI: 10.1002/Jlcr.1414 |
0.597 |
|
| 2007 |
Bendale P, Olepu S, Suryadevara PK, Bulbule V, Rivas K, Nallan L, Smart B, Yokoyama K, Ankala S, Pendyala PR, Floyd D, Lombardo LJ, Williams DK, Buckner FS, Chakrabarti D, ... ... Gelb MH, et al. Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials. Journal of Medicinal Chemistry. 50: 4585-605. PMID 17722901 DOI: 10.1021/Jm0703340 |
0.783 |
|
| 2007 |
Van Voorhis WC, Rivas KL, Bendale P, Nallan L, Hornéy C, Barrett LK, Bauer KD, Smart BP, Ankala S, Hucke O, Verlinde CL, Chakrabarti D, Strickland C, Yokoyama K, Buckner FS, ... ... Gelb MH, et al. Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase. Antimicrobial Agents and Chemotherapy. 51: 3659-71. PMID 17606674 DOI: 10.1128/Aac.00246-07 |
0.757 |
|
| 2007 |
Lu Y, Bottari P, Aebersold R, Turecek F, Gelb MH. Absolute quantification of specific proteins in complex mixtures using visible isotope-coded affinity tags. Methods in Molecular Biology (Clifton, N.J.). 359: 159-76. PMID 17484117 DOI: 10.1007/978-1-59745-255-7_11 |
0.44 |
|
| 2007 |
Turecek F, Scott CR, Gelb MH. Tandem mass spectrometry in the detection of inborn errors of metabolism for newborn screening. Methods in Molecular Biology (Clifton, N.J.). 359: 143-57. PMID 17484116 DOI: 10.1007/978-1-59745-255-7_10 |
0.322 |
|
| 2007 |
Henderson WR, Chi EY, Bollinger JG, Tien YT, Ye X, Castelli L, Rubtsov YP, Singer AG, Chiang GK, Nevalainen T, Rudensky AY, Gelb MH. Importance of group X-secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model. The Journal of Experimental Medicine. 204: 865-77. PMID 17403936 DOI: 10.1084/Jem.20070029 |
0.628 |
|
| 2007 |
Gillespie JR, Yokoyama K, Lu K, Eastman RT, Bollinger JG, Van Voorhis WC, Gelb MH, Buckner FS. C-terminal proteolysis of prenylated proteins in trypanosomatids and RNA interference of enzymes required for the post-translational processing pathway of farnesylated proteins. Molecular and Biochemical Parasitology. 153: 115-24. PMID 17397944 DOI: 10.1016/J.Molbiopara.2007.02.009 |
0.647 |
|
| 2007 |
Ghosh M, Loper R, Ghomashchi F, Tucker DE, Bonventre JV, Gelb MH, Leslie CC. Function, activity, and membrane targeting of cytosolic phospholipase A(2)zeta in mouse lung fibroblasts. The Journal of Biological Chemistry. 282: 11676-86. PMID 17293613 DOI: 10.1074/Jbc.M608458200 |
0.338 |
|
| 2007 |
Rouault M, Le Calvez C, Boilard E, Surrel F, Singer A, Ghomashchi F, Bezzine S, Scarzello S, Bollinger J, Gelb MH, Lambeau G. Recombinant production and properties of binding of the full set of mouse secreted phospholipases A2 to the mouse M-type receptor. Biochemistry. 46: 1647-62. PMID 17279628 DOI: 10.1021/Bi062119B |
0.622 |
|
| 2007 |
Eastman RT, White J, Hucke O, Yokoyama K, Verlinde CL, Hast MA, Beese LS, Gelb MH, Rathod PK, Van Voorhis WC. Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase. Molecular and Biochemical Parasitology. 152: 66-71. PMID 17208314 DOI: 10.1016/J.Molbiopara.2006.11.012 |
0.624 |
|
| 2007 |
Morgan D, Cherny VV, Finnegan A, Bollinger J, Gelb MH, DeCoursey TE. Sustained activation of proton channels and NADPH oxidase in human eosinophils and murine granulocytes requires PKC but not cPLA2 alpha activity. The Journal of Physiology. 579: 327-44. PMID 17185330 DOI: 10.1113/Jphysiol.2006.124248 |
0.607 |
|
| 2007 |
Wang D, Wood T, Sadilek M, Scott CR, Turecek F, Gelb MH. Tandem mass spectrometry for the direct assay of enzymes in dried blood spots: application to newborn screening for mucopolysaccharidosis II (Hunter disease). Clinical Chemistry. 53: 137-40. PMID 17082248 DOI: 10.1373/Clinchem.2006.077263 |
0.493 |
|
| 2006 |
Karabina SA, Brochériou I, Le Naour G, Agrapart M, Durand H, Gelb M, Lambeau G, Ninio E. Atherogenic properties of LDL particles modified by human group X secreted phospholipase A2 on human endothelial cell function. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 2547-9. PMID 17077289 DOI: 10.1096/Fj.06-6018Fje |
0.341 |
|
| 2006 |
Boilard E, Rouault M, Surrel F, Le Calvez C, Bezzine S, Singer A, Gelb MH, Lambeau G. Secreted phospholipase A2 inhibitors are also potent blockers of binding to the M-type receptor. Biochemistry. 45: 13203-18. PMID 17073442 DOI: 10.1021/Bi061376D |
0.354 |
|
| 2006 |
Gelb MH, Brunsveld L, Hrycyna CA, Michaelis S, Tamanoi F, Van Voorhis WC, Waldmann H. Therapeutic intervention based on protein prenylation and associated modifications. Nature Chemical Biology. 2: 518-28. PMID 16983387 DOI: 10.1038/Nchembio818 |
0.304 |
|
| 2006 |
Glenn MP, Chang SY, Hornéy C, Rivas K, Yokoyama K, Pusateri EE, Fletcher S, Cummings CG, Buckner FS, Pendyala PR, Chakrabarti D, Sebti SM, Gelb M, Van Voorhis WC, Hamilton AD. Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites. Journal of Medicinal Chemistry. 49: 5710-27. PMID 16970397 DOI: 10.1021/Jm060081V |
0.33 |
|
| 2006 |
Gora S, Lambeau G, Bollinger JG, Gelb M, Ninio E, Karabina SA. The proinflammatory mediator Platelet Activating Factor is an effective substrate for human group X secreted phospholipase A2. Biochimica Et Biophysica Acta. 1761: 1093-9. PMID 16962371 DOI: 10.1016/J.Bbalip.2006.08.004 |
0.674 |
|
| 2006 |
Gelb MH, Turecek F, Scott CR, Chamoles NA. Direct multiplex assay of enzymes in dried blood spots by tandem mass spectrometry for the newborn screening of lysosomal storage disorders. Journal of Inherited Metabolic Disease. 29: 397-404. PMID 16763908 DOI: 10.1007/S10545-006-0265-4 |
0.333 |
|
| 2006 |
Eerola LI, Surrel F, Nevalainen TJ, Gelb MH, Lambeau G, Laine VJ. Analysis of expression of secreted phospholipases A2 in mouse tissues at protein and mRNA levels. Biochimica Et Biophysica Acta. 1761: 745-56. PMID 16757211 DOI: 10.1016/J.Bbalip.2006.04.002 |
0.318 |
|
| 2006 |
Smart BP, Oslund RC, Walsh LA, Gelb MH. The first potent inhibitor of mammalian group X secreted phospholipase A2: elucidation of sites for enhanced binding. Journal of Medicinal Chemistry. 49: 2858-60. PMID 16686528 DOI: 10.1021/Jm060136T |
0.798 |
|
| 2006 |
Rouault M, Rash LD, Escoubas P, Boilard E, Bollinger J, Lomonte B, Maurin T, Guillaume C, Canaan S, Deregnaucourt C, Schrével J, Doglio A, Gutiérrez JM, Lazdunski M, Gelb MH, et al. Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity. Biochemistry. 45: 5800-16. PMID 16669624 DOI: 10.1021/Bi060217R |
0.637 |
|
| 2006 |
Ni Z, Okeley NM, Smart BP, Gelb MH. Intracellular actions of group IIA secreted phospholipase A2 and group IVA cytosolic phospholipase A2 contribute to arachidonic acid release and prostaglandin production in rat gastric mucosal cells and transfected human embryonic kidney cells. The Journal of Biological Chemistry. 281: 16245-55. PMID 16603549 DOI: 10.1074/Jbc.M513874200 |
0.765 |
|
| 2006 |
Huhtinen HT, Grönroos JO, Grönroos JM, Uksila J, Gelb MH, Nevalainen TJ, Laine VJO. Antibacterial effects of human group IIA and group XIIA phospholipase A2 against Helicobacter pylori in vitro Apmis. 114: 127-130. PMID 16519749 DOI: 10.1111/J.1600-0463.2006.Apm_330.X |
0.322 |
|
| 2005 |
Forsell PK, Olsson AO, Andersson E, Nallan L, Gelb MH. Polychlorinated biphenyls induce arachidonic acid release in human platelets in a tamoxifen sensitive manner via activation of group IVA cytosolic phospholipase A2-alpha. Biochemical Pharmacology. 71: 144-55. PMID 16290172 DOI: 10.1016/J.Bcp.2005.10.014 |
0.331 |
|
| 2005 |
Petan T, Križaj I, Gelb MH, Pungerčar J. Ammodytoxins, potent presynaptic neurotoxins, are also highly efficient phospholipase A2 enzymes Biochemistry. 44: 12535-12545. PMID 16156665 DOI: 10.1021/Bi051024R |
0.356 |
|
| 2005 |
Hucke O, Gelb MH, Verlinde CL, Buckner FS. The protein farnesyltransferase inhibitor Tipifarnib as a new lead for the development of drugs against Chagas disease. Journal of Medicinal Chemistry. 48: 5415-8. PMID 16107140 DOI: 10.1021/Jm050441Z |
0.359 |
|
| 2005 |
Tucker DE, Stewart A, Nallan L, Bendale P, Ghomashchi F, Gelb MH, Leslie CC. Group IVC cytosolic phospholipase A2γ is farnesylated and palmitoylated in mammalian cells Journal of Lipid Research. 46: 2122-2133. PMID 16061942 DOI: 10.1194/Jlr.M500230-Jlr200 |
0.329 |
|
| 2005 |
Nallan L, Bauer KD, Bendale P, Rivas K, Yokoyama K, Hornéy CP, Pendyala PR, Floyd D, Lombardo LJ, Williams DK, Hamilton A, Sebti S, Windsor WT, Weber PC, Buckner FS, ... ... Gelb MH, et al. Protein farnesyltransferase inhibitors exhibit potent antimalarial activity. Journal of Medicinal Chemistry. 48: 3704-13. PMID 15916422 DOI: 10.1021/Jm0491039 |
0.319 |
|
| 2005 |
Babon A, Almunia C, Boccaccio C, Beaumelle B, Gelb MH, Ménez A, Maillère B, Abastado JP, Salcedo M, Gillet D. Cross-presentation of a CMV pp65 epitope by human dendritic cells using bee venom PLA2 as a membrane-binding vector Febs Letters. 579: 1658-1664. PMID 15757657 DOI: 10.1016/J.Febslet.2005.02.019 |
0.301 |
|
| 2005 |
Wang D, Eadala B, Sadilek M, Chamoles NA, Turecek F, Scott CR, Gelb MH. Tandem mass spectrometric analysis of dried blood spots for screening of mucopolysaccharidosis I in newborns. Clinical Chemistry. 51: 898-900. PMID 15695324 DOI: 10.1373/Clinchem.2004.047167 |
0.467 |
|
| 2005 |
Eastman RT, White J, Hucke O, Bauer K, Yokoyama K, Nallan L, Chakrabarti D, Verlinde CL, Gelb MH, Rathod PK, Van Voorhis WC. Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum. The Journal of Biological Chemistry. 280: 13554-9. PMID 15661734 DOI: 10.1074/Jbc.M413556200 |
0.613 |
|
| 2005 |
Haas U, Podda M, Behne M, Gurrieri S, Alonso A, Fürstenberger G, Pfeilschifter J, Lambeau G, Gelb MH, Kaszkin M. Characterization and differentiation-dependent regulation of secreted phospholipases A in human keratinocytes and in healthy and psoriatic human skin. The Journal of Investigative Dermatology. 124: 204-11. PMID 15654975 DOI: 10.1111/J.0022-202X.2004.23513.X |
0.322 |
|
| 2005 |
Granata F, Petraroli A, Boilard E, Bezzine S, Bollinger J, Del Vecchio L, Gelb MH, Lambeau G, Marone G, Triggiani M. Activation of cytokine production by secreted phospholipase A2 in human lung macrophages expressing the M-type receptor. Journal of Immunology (Baltimore, Md. : 1950). 174: 464-74. PMID 15611272 DOI: 10.4049/Jimmunol.174.1.464 |
0.639 |
|
| 2005 |
Rubin BB, Downey GP, Koh A, Degousee N, Ghomashchi F, Nallan L, Stefanski E, Harkin DW, Sun C, Smart BP, Lindsay TF, Cherepanov V, Vachon E, Kelvin D, Sadilek M, ... ... Gelb MH, et al. Cytosolic phospholipase A2-alpha is necessary for platelet-activating factor biosynthesis, efficient neutrophil-mediated bacterial killing, and the innate immune response to pulmonary infection: cPLA2-alpha does not regulate neutrophil NADPH oxidase activity. The Journal of Biological Chemistry. 280: 7519-29. PMID 15475363 DOI: 10.1074/Jbc.M407438200 |
0.754 |
|
| 2004 |
Carrico D, Ohkanda J, Kendrick H, Yokoyama K, Blaskovich MA, Bucher CJ, Buckner FS, Van Voorhis WC, Chakrabarti D, Croft SL, Gelb MH, Sebti SM, Hamilton AD. In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability. Bioorganic & Medicinal Chemistry. 12: 6517-26. PMID 15556768 DOI: 10.1016/J.Bmc.2004.09.020 |
0.384 |
|
| 2004 |
Bollinger JG, Diraviyam K, Ghomashchi F, Murray D, Gelb MH. Interfacial binding of bee venom secreted phospholipase A2 to membranes occurs predominantly by a nonelectrostatic mechanism. Biochemistry. 43: 13293-304. PMID 15491136 DOI: 10.1021/Bi049390I |
0.628 |
|
| 2004 |
Li Y, Scott CR, Chamoles NA, Ghavami A, Pinto BM, Turecek F, Gelb MH. Direct multiplex assay of lysosomal enzymes in dried blood spots for newborn screening. Clinical Chemistry. 50: 1785-96. PMID 15292070 DOI: 10.1373/Clinchem.2004.035907 |
0.546 |
|
| 2004 |
Lu Y, Bottari P, Turecek F, Aebersold R, Gelb MH. Absolute quantification of specific proteins in complex mixtures using visible isotope-coded affinity tags. Analytical Chemistry. 76: 4104-11. PMID 15253649 DOI: 10.1021/Ac049905B |
0.451 |
|
| 2004 |
Leslie CC, Gelb MH. Assaying phospholipase A2 activity Methods in Molecular Biology (Clifton, N.J.). 284: 229-242. PMID 15173620 DOI: 10.1385/1-59259-816-1:229 |
0.372 |
|
| 2004 |
Smart BP, Pan YH, Weeks AK, Bollinger JG, Bahnson BJ, Gelb MH. Inhibition of the complete set of mammalian secreted phospholipases A(2) by indole analogues: a structure-guided study. Bioorganic & Medicinal Chemistry. 12: 1737-49. PMID 15028265 DOI: 10.1016/J.Bmc.2004.01.022 |
0.802 |
|
| 2004 |
Mounier CM, Ghomashchi F, Lindsay MR, James S, Singer AG, Parton RG, Gelb MH. Arachidonic acid release from mammalian cells transfected with human groups IIA and X secreted phospholipase A2 occurs predominantly during the secretory process and with the involvement of cytosolic phospholipase A2-α Journal of Biological Chemistry. 279: 25024-25038. PMID 15007070 DOI: 10.1074/Jbc.M313019200 |
0.355 |
|
| 2004 |
Triggiani M, Giannattasio G, Balestrieri B, Granata F, Gelb MH, De Paulis A, Marone G. Differential modulation of mediator release from human basophils and mast cells by mizolastine Clinical and Experimental Allergy. 34: 241-249. PMID 14987304 DOI: 10.1111/J.1365-2222.2004.01851.X |
0.319 |
|
| 2004 |
Li Y, Brockmann K, Turecek F, Scott CR, Gelb MH. Tandem mass spectrometry for the direct assay of enzymes in dried blood spots: application to newborn screening for Krabbe disease. Clinical Chemistry. 50: 638-40. PMID 14981030 DOI: 10.1373/Clinchem.2003.028381 |
0.533 |
|
| 2004 |
Canaan S, Zádori Z, Ghomashchi F, Bollinger J, Sadilek M, Moreau ME, Tijssen P, Gelb MH. Interfacial enzymology of parvovirus phospholipases A2. The Journal of Biological Chemistry. 279: 14502-8. PMID 14726513 DOI: 10.1074/Jbc.M312630200 |
0.673 |
|
| 2004 |
Ohkanda J, Buckner FS, Lockman JW, Yokoyama K, Carrico D, Eastman R, de Luca-Fradley K, Davies W, Croft SL, Van Voorhis WC, Gelb MH, Sebti SM, Hamilton AD. Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents. Journal of Medicinal Chemistry. 47: 432-45. PMID 14711313 DOI: 10.1021/Jm030236O |
0.399 |
|
| 2003 |
Buckner F, Yokoyama K, Lockman J, Aikenhead K, Ohkanda J, Sadilek M, Sebti S, Van Voorhis W, Hamilton A, Gelb MH. A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents. Proceedings of the National Academy of Sciences of the United States of America. 100: 15149-53. PMID 14657358 DOI: 10.1073/Pnas.2535442100 |
0.347 |
|
| 2003 |
Rouault M, Bollinger JG, Lazdunski M, Gelb MH, Lambeau G. Novel mammalian group XII secreted phospholipase A2 lacking enzymatic activity. Biochemistry. 42: 11494-503. PMID 14516201 DOI: 10.1021/Bi0349930 |
0.657 |
|
| 2003 |
Chabot S, Koumanov K, Lambeau G, Gelb MH, Balloy V, Chignard M, Whitsett JA, Touqui L. Inhibitory effects of surfactant protein A on surfactant phospholipid hydrolysis by secreted phospholipases A2 Journal of Immunology. 171: 995-1000. PMID 12847272 DOI: 10.4049/Jimmunol.171.2.995 |
0.309 |
|
| 2003 |
Gurrieri S, Fürstenberger G, Schadow A, Haas U, Singer AG, Ghomashchi F, Pfeilschifter J, Lambeau G, Gelb MH, Kaszkin M. Differentiation-dependent regulation of secreted phospholipases A2 in murine epidermis Journal of Investigative Dermatology. 121: 156-164. PMID 12839576 DOI: 10.1046/J.1523-1747.2003.12315.X |
0.304 |
|
| 2003 |
Beers SA, Buckland AG, Giles N, Gelb MH, Wilton DC. Effect of tryptophan insertions on the properties of the human group IIA phospholipase A2: mutagenesis produces an enzyme with characteristics similar to those of the human group V phospholipase A2. Biochemistry. 42: 7326-38. PMID 12809488 DOI: 10.1021/Bi0343222 |
0.394 |
|
| 2003 |
Poi MJ, Tomaszewski JW, Yuan C, Dunlap CA, Andersen NH, Gelb MH, Tsai MD. A low-barrier hydrogen bond between histidine of secreted phospholipase A2 and a transition state analog inhibitor. Journal of Molecular Biology. 329: 997-1009. PMID 12798689 DOI: 10.1016/S0022-2836(03)00512-6 |
0.312 |
|
| 2003 |
Beck S, Lambeau G, Scholz-Pedretti K, Gelb MH, Janssen MJ, Edwards SH, Wilton DC, Pfeilschifter J, Kaszkin M. Potentiation of tumor necrosis factor alpha-induced secreted phospholipase A2 (sPLA2)-IIA expression in mesangial cells by an autocrine loop involving sPLA2 and peroxisome proliferator-activated receptor alpha activation. The Journal of Biological Chemistry. 278: 29799-812. PMID 12782627 DOI: 10.1074/Jbc.M211763200 |
0.301 |
|
| 2003 |
Ferri N, Yokoyama K, Sadilek M, Paoletti R, Apitz-Castro R, Gelb MH, Corsini A. Ajoene, a garlic compound, inhibits protein prenylation and arterial smooth muscle cell proliferation British Journal of Pharmacology. 138: 811-818. PMID 12642382 DOI: 10.1038/Sj.Bjp.0705126 |
0.346 |
|
| 2003 |
Gelb MH, Van Voorhis WC, Buckner FS, Yokoyama K, Eastman R, Carpenter EP, Panethymitaki C, Brown KA, Smith DF. Protein farnesyl and N-myristoyl transferases: Piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics Molecular and Biochemical Parasitology. 126: 155-163. PMID 12615314 DOI: 10.1016/S0166-6851(02)00282-7 |
0.331 |
|
| 2003 |
Li Y, Ogata Y, Freeze HH, Scott CR, Turecek F, Gelb MH. Affinity capture and elution/electrospray ionization mass spectrometry assay of phosphomannomutase and phosphomannose isomerase for the multiplex analysis of congenital disorders of glycosylation types Ia and Ib. Analytical Chemistry. 75: 42-8. PMID 12530817 DOI: 10.1021/Ac0205053 |
0.539 |
|
| 2003 |
Murakami M, Masuda S, Shimbara S, Bezzine S, Lazdunski M, Lambeau G, Gelb MH, Matsukura S, Kokubu F, Adachi M, Kudo I. Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2S (groups III and XII) Journal of Biological Chemistry. 278: 10657-10667. PMID 12522102 DOI: 10.1074/Jbc.M211325200 |
0.358 |
|
| 2002 |
Choe J, Suresh S, Wisedchaisri G, Kennedy KJ, Gelb MH, Hol WG. Anomalous differences of light elements in determining precise binding modes of ligands to glycerol-3-phosphate dehydrogenase. Chemistry & Biology. 9: 1189-97. PMID 12445769 DOI: 10.1016/S1074-5521(02)00243-0 |
0.333 |
|
| 2002 |
Koprivnjak T, Peschel A, Gelb MH, Liang NS, Weiss JP. Role of charge properties of bacterial envelope in bactericidal action of human group IIA phospholipase A2 against Staphylococcus aureus. The Journal of Biological Chemistry. 277: 47636-44. PMID 12359734 DOI: 10.1074/Jbc.M205104200 |
0.34 |
|
| 2002 |
Singer AG, Ghomashchi F, Le Calvez C, Bollinger J, Bezzine S, Rouault M, Sadilek M, Nguyen E, Lazdunski M, Lambeau G, Gelb MH. Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2. The Journal of Biological Chemistry. 277: 48535-49. PMID 12359733 DOI: 10.1074/Jbc.M205855200 |
0.685 |
|
| 2002 |
Bezzine S, Bollinger JG, Singer AG, Veatch SL, Keller SL, Gelb MH. On the binding preference of human groups IIA and X phospholipases A2 for membranes with anionic phospholipids. The Journal of Biological Chemistry. 277: 48523-34. PMID 12244093 DOI: 10.1074/Jbc.M203137200 |
0.646 |
|
| 2002 |
Pan YH, Yu BZ, Singer AG, Ghomashchi F, Lambeau G, Gelb MH, Jain MK, Bahnson BJ. Crystal structure of human group X secreted phospholipase A2. Electrostatically neutral interfacial surface targets zwitterionic membranes. The Journal of Biological Chemistry. 277: 29086-93. PMID 12161451 DOI: 10.1074/Jbc.M202531200 |
0.373 |
|
| 2002 |
Clerici F, Gelmi ML, Yokoyama K, Pocar D, Van Voorhis WC, Buckner FS, Gelb MH. Isothiazole dioxides: Synthesis and inhibition of Trypanosoma brucei protein farnesyltransferase Bioorganic and Medicinal Chemistry Letters. 12: 2217-2220. PMID 12127541 DOI: 10.1016/S0960-894X(02)00338-4 |
0.328 |
|
| 2002 |
Canaan S, Nielsen R, Ghomashchi F, Robinson BH, Gelb MH. Unusual mode of binding of human group IIA secreted phospholipase A2 to anionic interfaces as studied by continuous wave and time domain electron paramagnetic resonance spectroscopy. The Journal of Biological Chemistry. 277: 30984-90. PMID 12039961 DOI: 10.1074/Jbc.M203649200 |
0.317 |
|
| 2002 |
Murakami M, Yoshihara K, Shimbara S, Lambeau G, Singer A, Gelb MH, Sawada M, Inagaki N, Nagai H, Kudo I. Arachidonate release and eicosanoid generation by group IIE phospholipase A 2 Biochemical and Biophysical Research Communications. 292: 689-696. PMID 11922621 DOI: 10.1006/Bbrc.2002.6716 |
0.341 |
|
| 2002 |
Murakami M, Yoshihara K, Shimbara S, Lambeau G, Gelb MH, Singer AG, Sawada M, Inagaki N, Nagai H, Ishihara M, Ishikawa Y, Ishii T, Kudo I. Cellular arachidonate-releasing function and inflammation-associated expression of group IIF secretory phospholipase A2. The Journal of Biological Chemistry. 277: 19145-55. PMID 11877435 DOI: 10.1074/Jbc.M112385200 |
0.341 |
|
| 2002 |
Degousee N, Ghomashchi F, Stefanski E, Singer A, Smart BP, Borregaard N, Reithmeier R, Lindsay TF, Lichtenberger C, Reinisch W, Lambeau G, Arm J, Tischfield J, Gelb MH, Rubin BB. Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis. The Journal of Biological Chemistry. 277: 5061-73. PMID 11741884 DOI: 10.1074/Jbc.M109083200 |
0.787 |
|
| 2002 |
Beers SA, Buckland AG, Koduri RS, Cho W, Gelb MH, Wilton DC. The antibacterial properties of secreted phospholipases A2: a major physiological role for the group IIA enzyme that depends on the very high pI of the enzyme to allow penetration of the bacterial cell wall. The Journal of Biological Chemistry. 277: 1788-93. PMID 11706041 DOI: 10.1074/Jbc.M109777200 |
0.358 |
|
| 2002 |
Verlinde CLMJ, Bressi JC, Choe J, Suresh S, Buckner FS, Van Voorhis WC, Michels PAM, Gelb MH, Hol WGJ. Protein structure-based design of anti-protozoal drugs Journal of the Brazilian Chemical Society. 13: 843-848. |
0.762 |
|
| 2001 |
Ferri N, Arnaboldi L, Orlandi A, Yokoyama K, Gree R, Granata A, Hachem A, Paoletti R, Gelb MH, Corsini A. Effect of S(-) perillic acid on protein prenylation and arterial smooth muscle cell proliferation Biochemical Pharmacology. 62: 1637-1645. PMID 11755117 DOI: 10.1016/S0006-2952(01)00808-5 |
0.309 |
|
| 2001 |
Koduri RS, Grönroos JO, Laine VJ, Le Calvez C, Lambeau G, Nevalainen TJ, Gelb MH. Bactericidal properties of human and murine groups I, II, V, X, and XII secreted phospholipases A(2). The Journal of Biological Chemistry. 277: 5849-57. PMID 11694541 DOI: 10.1074/Jbc.M109699200 |
0.347 |
|
| 2001 |
Verlinde CL, Hannaert V, Blonski C, Willson M, Périé JJ, Fothergill-Gilmore LA, Opperdoes FR, Gelb MH, Hol WG, Michels PA. Glycolysis as a target for the design of new anti-trypanosome drugs. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 4: 50-65. PMID 11512153 DOI: 10.1054/Drup.2000.0177 |
0.367 |
|
| 2001 |
Muthalif MM, Hefner Y, Canaan S, Harper J, Zhou H, Parmentier JH, Aebersold R, Gelb MH, Malik KU. Functional interaction of calcium-/calmodulin-dependent protein kinase II and cytosolic phospholipase A(2). The Journal of Biological Chemistry. 276: 39653-60. PMID 11479288 DOI: 10.1074/Jbc.M103136200 |
0.316 |
|
| 2001 |
Ghomashchi F, Stewart A, Hefner Y, Ramanadham S, Turk J, Leslie CC, Gelb MH. A pyrrolidine-based specific inhibitor of cytosolic phospholipase A(2)alpha blocks arachidonic acid release in a variety of mammalian cells. Biochimica Et Biophysica Acta. 1513: 160-6. PMID 11470087 DOI: 10.1016/S0005-2736(01)00349-2 |
0.324 |
|
| 2001 |
Gerber SA, Tureček F, Gelb MH. Design and synthesis of substrate and internal standard conjugates for profiling enzyme activity in the sanfilippo syndrome by affinity chromatography/electrospray ionization mass spectrometry Bioconjugate Chemistry. 12: 603-615. PMID 11459466 DOI: 10.1021/Bc010007L |
0.331 |
|
| 2001 |
Bressi JC, Verlinde CL, Aronov AM, Shaw ML, Shin SS, Nguyen LN, Suresh S, Buckner FS, Van Voorhis WC, Kuntz ID, Hol WG, Gelb MH. Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design. Journal of Medicinal Chemistry. 44: 2080-93. PMID 11405646 DOI: 10.1021/Jm000472O |
0.792 |
|
| 2001 |
Suresh S, Bressi JC, Kennedy KJ, Verlinde CL, Gelb MH, Hol WG. Conformational changes in Leishmania mexicana glyceraldehyde-3-phosphate dehydrogenase induced by designed inhibitors. Journal of Molecular Biology. 309: 423-35. PMID 11371162 DOI: 10.1006/Jmbi.2001.4588 |
0.805 |
|
| 2001 |
Min JH, Wilder C, Aoki J, Arai H, Inoue K, Paul L, Gelb MH. Platelet-activating factor acetylhydrolases: broad substrate specificity and lipoprotein binding does not modulate the catalytic properties of the plasma enzyme. Biochemistry. 40: 4539-49. PMID 11294621 DOI: 10.1021/Bi002600G |
0.611 |
|
| 2001 |
Ohkanda J, Lockman JW, Yokoyama K, Gelb MH, Croft SL, Kendrick H, Harrell MI, Feagin JE, Blaskovich MA, Sebti SM, Hamilton AD. Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity. Bioorganic & Medicinal Chemistry Letters. 11: 761-4. PMID 11277514 DOI: 10.1016/S0960-894X(01)00055-5 |
0.313 |
|
| 2001 |
Kennedy KJ, Bressi JC, Gelb MH. A disubstituted NAD+ analogue is a nanomolar inhibitor of trypanosomal glyceraldehyde-3-phosphate dehydrogenase. Bioorganic & Medicinal Chemistry Letters. 11: 95-8. PMID 11206479 DOI: 10.1016/S0960-894X(00)00608-9 |
0.789 |
|
| 2001 |
Schadow A, Scholz-Pedretti K, Lambeau G, Gelb MH, Fürstenberger G, Pfeilschifter J, Kaszkin M. Characterization of group X phospholipase A(2) as the major enzyme secreted by human keratinocytes and its regulation by the phorbol ester TPA. The Journal of Investigative Dermatology. 116: 31-9. PMID 11168795 DOI: 10.1046/J.1523-1747.2001.00179.X |
0.373 |
|
| 2001 |
Valentin E, Singer AG, Ghomashchi F, Lazdunski M, Gelb MH, Lambeau G. Cloning and recombinant expression of human group IIF-secreted phospholipase A(2). Biochemical and Biophysical Research Communications. 279: 223-8. PMID 11112443 DOI: 10.1006/Bbrc.2000.3908 |
0.35 |
|
| 2001 |
Gelb MH, Valentin E, Ghomashchi F, Lazdunski M, Lambeau G. Cloning and recombinant expression of a structurally novel human secreted phospholipase A2. The Journal of Biological Chemistry. 275: 39823-6. PMID 11031251 DOI: 10.1074/Jbc.C000671200 |
0.365 |
|
| 2001 |
Zhou X, Tureček F, Scott CR, Gelb MH. Quantification of Cellular Acid Sphingomyelinase and Galactocerebroside β-Galactosidase Activities by Electrospray Ionization Mass Spectrometry Clinical Chemistry. 47: 874-881. DOI: 10.1093/Clinchem/47.5.874 |
0.328 |
|
| 2001 |
Yokoyama K, Gelb MH. 5 Protein geranylgeranyltransferase type I The Enzymes. 21: 105-130. DOI: 10.1016/S1874-6047(01)80018-4 |
0.324 |
|
| 2000 |
Murakami M, Koduri RS, Enomoto A, Shimbara S, Seki M, Yoshihara K, Singer A, Valentin E, Ghomashchi F, Lambeau G, Gelb MH, Kudo I. Distinct arachidonate-releasing functions of mammalian secreted phospholipase A2s in human embryonic kidney 293 and rat mastocytoma RBL-2H3 cells through heparan sulfate shuttling and external plasma membrane mechanisms. The Journal of Biological Chemistry. 276: 10083-96. PMID 11106649 DOI: 10.1074/Jbc.M007877200 |
0.355 |
|
| 2000 |
Gelb MH, Min JH, Jain MK. Do membrane-bound enzymes access their substrates from the membrane or aqueous phase: interfacial versus non-interfacial enzymes. Biochimica Et Biophysica Acta. 1488: 20-7. PMID 11080673 DOI: 10.1016/S1388-1981(00)00106-2 |
0.568 |
|
| 2000 |
Bressi JC, Choe J, Hough MT, Buckner FS, Van Voorhis WC, Verlinde CL, Hol WG, Gelb MH. Adenosine analogues as inhibitors of Trypanosoma brucei phosphoglycerate kinase: elucidation of a novel binding mode for a 2-amino-N(6)-substituted adenosine. Journal of Medicinal Chemistry. 43: 4135-50. PMID 11063610 DOI: 10.1021/Jm000287A |
0.798 |
|
| 2000 |
Enomoto A, Murakami M, Valentin E, Lambeau G, Gelb MH, Kudo I. Redundant and segregated functions of granule-associated heparin-binding group II subfamily of secretory phospholipases A2 in the regulation of degranulation and prostaglandin D2 synthesis in mast cells Journal of Immunology. 165: 4007-4014. PMID 11034411 DOI: 10.4049/Jimmunol.165.7.4007 |
0.341 |
|
| 2000 |
Golisade A, Bressi JC, Van Calenbergh S, Gelb MH, Link A. Polymer-assisted solution-phase synthesis of 2'-amido-2'-deoxyadenosine derivatives targeted at the NAD(+)-binding sites of parasite enzymes. Journal of Combinatorial Chemistry. 2: 537-44. PMID 11029179 DOI: 10.1021/Cc0000343 |
0.783 |
|
| 2000 |
Mounier CM, Luchetta P, Lecut C, Koduri RS, Faure G, Lambeau G, Valentin E, Singer A, Ghomashchi F, Béguin S, Gelb MH, Bon C. Basic residues of human group IIA phospholipase A2 are important for binding to factor Xa and prothrombinase inhibition comparison with other mammalian secreted phospholipases A2. European Journal of Biochemistry. 267: 4960-9. PMID 10931177 DOI: 10.1046/J.1432-1327.2000.01523.X |
0.376 |
|
| 2000 |
Whitten ME, Yokoyama K, Schieltz D, Ghomashchi F, Lam D, Yates JR, Palczewski K, Gelb MH. Structural analysis of protein prenyl groups and associated C-terminal modifications. Methods in Enzymology. 316: 436-51. PMID 10800693 DOI: 10.1016/S0076-6879(00)16741-2 |
0.349 |
|
| 2000 |
Buckner FS, Yokoyama K, Nguyen L, Grewal A, Erdjument-Bromage H, Tempst P, Strickland CL, Xiao L, Van Voorhis WC, Gelb MH. Cloning, heterologous expression, and distinct substrate specificity of protein farnesyltransferase from Trypanosoma brucei. The Journal of Biological Chemistry. 275: 21870-6. PMID 10749864 DOI: 10.1074/Jbc.M000975200 |
0.362 |
|
| 2000 |
Valentin E, Ghomashchi F, Gelb MH, Lazdunski M, Lambeau G. Novel human secreted phospholipase A(2) with homology to the group III bee venom enzyme. The Journal of Biological Chemistry. 275: 7492-6. PMID 10713052 DOI: 10.1074/Jbc.275.11.7492 |
0.35 |
|
| 2000 |
Bezzine S, Koduri RS, Valentin E, Murakami M, Kudo I, Ghomashchi F, Sadilek M, Lambeau G, Gelb MH. Exogenously added human group X secreted phospholipase A(2) but not the group IB, IIA, and V enzymes efficiently release arachidonic acid from adherent mammalian cells. The Journal of Biological Chemistry. 275: 3179-91. PMID 10652303 DOI: 10.1074/Jbc.275.5.3179 |
0.379 |
|
| 2000 |
Valentin E, Lambeau G, Koduri R, Ghomashchi F, Fenard D, Doglio A, Gelb M, Lazdunski M. The Expanding Family of Secreted Phospholipases A2: diversity of enzymes for diverse functions? Biochemical Society Transactions. 28: A453-A453. DOI: 10.1042/Bst028A453 |
0.3 |
|
| 2000 |
Jung LS, Shumaker-Parry JS, Campbell CT, Yee SS, Gelb MH. Quantification of tight binding to surface-immobilized phospholipid vesicles using surface plasmon resonance: Binding constant of phospholipase A2 Journal of the American Chemical Society. 122: 4177-4184. DOI: 10.1021/Ja993879V |
0.307 |
|
| 1999 |
Buschbeck M, Ghomashchi F, Gelb MH, Watson SP, Börsch-Haubold AG. Stress stimuli increase calcium-induced arachidonic acid release through phosphorylation of cytosolic phospholipase A2 Biochemical Journal. 344: 359-366. PMID 10567216 DOI: 10.1042/0264-6021:3440359 |
0.328 |
|
| 1999 |
Valentin E, Ghomashchi F, Gelb MH, Lazdunski M, Lambeau G. On the diversity of secreted phospholipases A(2). Cloning, tissue distribution, and functional expression of two novel mouse group II enzymes. The Journal of Biological Chemistry. 274: 31195-202. PMID 10531313 DOI: 10.1074/Jbc.274.44.31195 |
0.347 |
|
| 1999 |
Min JH, Jain MK, Wilder C, Paul L, Apitz-Castro R, Aspleaf DC, Gelb MH. Membrane-bound plasma platelet activating factor acetylhydrolase acts on substrate in the aqueous phase. Biochemistry. 38: 12935-42. PMID 10504265 DOI: 10.1021/Bi991149U |
0.589 |
|
| 1999 |
Börsch-Haubold AG, Ghomashchi F, Pasquet S, Goedert M, Cohen P, Gelb MH, Watson SP. Phosphorylation of cytosolic phospholipase A2 in platelets is mediated by multiple stress-activated protein kinase pathways. European Journal of Biochemistry / Febs. 265: 195-203. PMID 10491174 DOI: 10.1046/J.1432-1327.1999.00722.X |
0.308 |
|
| 1999 |
Gelb MH, Cho W, Wilton DC. Interfacial binding of secreted phospholipases A(2): more than electrostatics and a major role for tryptophan. Current Opinion in Structural Biology. 9: 428-32. PMID 10449366 DOI: 10.1016/S0959-440X(99)80059-1 |
0.324 |
|
| 1999 |
Ghomashchi F, Loo R, Balsinde J, Bartoli F, Apitz-Castro R, Clark JD, Dennis EA, Gelb MH. Trifluoromethyl ketones and methyl fluorophosphonates as inhibitors of group IV and VI phospholipases A2: Structure-function studies with vesicle, micelle, and membrane assays Biochimica Et Biophysica Acta - Biomembranes. 1420: 45-56. PMID 10446289 DOI: 10.1016/S0005-2736(99)00056-5 |
0.378 |
|
| 1999 |
Valentin E, Koduri RS, Scimeca JC, Carle G, Gelb MH, Lazdunski M, Lambeau G. Cloning and recombinant expression of a novel mouse-secreted phospholipase A2. The Journal of Biological Chemistry. 274: 19152-60. PMID 10383420 DOI: 10.1074/Jbc.274.27.19152 |
0.4 |
|
| 1999 |
Bryant MD, Flick KE, Koduri RS, Wilton DC, Stoddard BL, Gelb MH. 1,3-Dioxane-4,6-dione-5-carboxamide-based inhibitors of human group IIA phospholipase A: X-ray structure of the complex and interfacial selection of inhibitors from a structural library. Bioorganic & Medicinal Chemistry Letters. 9: 1097-102. PMID 10328292 DOI: 10.1016/S0960-894X(99)00147-X |
0.384 |
|
| 1999 |
Han SK, Kim KP, Koduri R, Bittova L, Munoz NM, Leff AR, Wilton DC, Gelb MH, Cho W. Roles of Trp31 in high membrane binding and proinflammatory activity of human group V phospholipase A2. The Journal of Biological Chemistry. 274: 11881-8. PMID 10207008 DOI: 10.1074/Jbc.274.17.11881 |
0.368 |
|
| 1999 |
Aronov AM, Suresh S, Buckner FS, Van Voorhis WC, Verlinde CL, Opperdoes FR, Hol WG, Gelb MH. Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase. Proceedings of the National Academy of Sciences of the United States of America. 96: 4273-8. PMID 10200252 DOI: 10.1073/Pnas.96.8.4273 |
0.394 |
|
| 1999 |
Aronov AM, Gelb MH. Synthesis and structure-activity relationships of adenosine analogs as inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase. Modifications at positions 5' and 8. Bioorganic & Medicinal Chemistry Letters. 8: 3505-10. PMID 9934461 DOI: 10.1016/S0960-894X(98)00635-0 |
0.365 |
|
| 1999 |
Gerber SA, Scott CR, Turecek F, Gelb MH. Analysis of rates of multiple enzymes in cell lysates by electrospray ionization mass spectrometry [8] Journal of the American Chemical Society. 121: 1102-1103. DOI: 10.1021/Ja982878K |
0.331 |
|
| 1998 |
Koduri RS, Baker SF, Snitko Y, Han SK, Cho W, Wilton DC, Gelb MH. Action of human group IIa secreted phospholipase A2 on cell membranes. Vesicle but not heparinoid binding determines rate of fatty acid release by exogenously added enzyme. The Journal of Biological Chemistry. 273: 32142-53. PMID 9822691 DOI: 10.1074/Jbc.273.48.32142 |
0.37 |
|
| 1998 |
Aronov AM, Verlinde CL, Hol WG, Gelb MH. Selective tight binding inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase via structure-based drug design. Journal of Medicinal Chemistry. 41: 4790-9. PMID 9822549 DOI: 10.1021/Jm9802620 |
0.407 |
|
| 1998 |
Lin Y, Ghomashchi F, Nielsen R, Snitko Y, Yu BZ, Han SK, Cho W, Wilton DC, Jain MK, Robinson BH, Gelb MH. Binding of bee venom and human group IIa phospholipases A2 to membranes: a minor role for electrostatics. Biochemical Society Transactions. 26: 341-5. PMID 9765875 DOI: 10.1042/Bst0260341 |
0.314 |
|
| 1998 |
Yokoyama K, Trobridge P, Buckner FS, Van Voorhis WC, Stuart KD, Gelb MH. Protein farnesyltransferase from Trypanosoma brucei. A heterodimer of 61- and 65-kDa subunits as a new target for antiparasite therapeutics Journal of Biological Chemistry. 273: 26497-26505. PMID 9756885 DOI: 10.1074/Jbc.273.41.26497 |
0.376 |
|
| 1998 |
Yokoyama K, Trobridge P, Buckner FS, Scholten J, Stuart KD, Van Voorhis WC, Gelb MH. The effects of protein farnesyltransferase inhibitors on trypanosomatids: Inhibition of protein farnesylation and cell growth Molecular and Biochemical Parasitology. 94: 87-97. PMID 9719512 DOI: 10.1016/S0166-6851(98)00053-X |
0.341 |
|
| 1998 |
Bernstein BE, Williams DM, Bressi JC, Kuhn P, Gelb MH, Blackburn GM, Hol WG. A bisubstrate analog induces unexpected conformational changes in phosphoglycerate kinase from Trypanosoma brucei. Journal of Molecular Biology. 279: 1137-48. PMID 9642090 DOI: 10.1006/Jmbi.1998.1835 |
0.792 |
|
| 1998 |
Hixon MS, Ball A, Gelb MH. Calcium-dependent and -independent interfacial binding and catalysis of cytosolic group IV phospholipase A2. Biochemistry. 37: 8516-26. PMID 9622504 DOI: 10.1021/Bi980416D |
0.303 |
|
| 1998 |
Ghomashchi F, Lin Y, Hixon MS, Yu BZ, Annand R, Jain MK, Gelb MH. Interfacial recognition by bee venom phospholipase A2: insights into nonelectrostatic molecular determinants by charge reversal mutagenesis. Biochemistry. 37: 6697-710. PMID 9578553 DOI: 10.1021/Bi972525I |
0.31 |
|
| 1998 |
Jang GF, Gelb MH. Substrate specificity of mammalian prenyl protein-specific endoprotease activity. Biochemistry. 37: 4473-81. PMID 9521767 DOI: 10.1021/Bi972289B |
0.338 |
|
| 1997 |
Snitko Y, Koduri RS, Han SK, Othman R, Baker SF, Molini BJ, Wilton DC, Gelb MH, Cho W. Mapping the interfacial binding surface of human secretory group IIa phospholipase A2. Biochemistry. 36: 14325-33. PMID 9398150 DOI: 10.1021/Bi971200Z |
0.336 |
|
| 1997 |
Schneider T, Dudler T, Annand RR, Gelb MH, King TP, Suter M. Comparison of the antibody response to bee venom phospholipase A2 induced by natural exposure in humans or by immunization in mice. Journal of Molecular Recognition : Jmr. 10: 93-100. PMID 9376132 DOI: 10.1002/(Sici)1099-1352(199703/04)10:2<93::Aid-Jmr346>3.0.Co;2-2 |
0.313 |
|
| 1997 |
Carlson PA, Gelb MH, Yager P. Zero-order interfacial enzymatic degradation of phospholipid tubules Biophysical Journal. 73: 230-238. PMID 9199787 DOI: 10.1016/S0006-3495(97)78063-9 |
0.324 |
|
| 1997 |
Bayburt T, Gelb MH. Interfacial catalysis by human 85 kDa cytosolic phospholipase A2 on anionic vesicles in the scooting mode. Biochemistry. 36: 3216-31. PMID 9115999 DOI: 10.1021/Bi961659D |
0.352 |
|
| 1997 |
Yu BZ, Ghomashchi F, Cajal Y, Annand RR, Berg OG, Gelb MH, Jain MK. Use of an imperfect neutral diluent and outer vesicle layer scooting mode hydrolysis to analyze the interfacial kinetics, inhibition, and substrate preferences of bee venom phospholipase A2. Biochemistry. 36: 3870-81. PMID 9092817 DOI: 10.1021/Bi961541X |
0.363 |
|
| 1997 |
Yokoyama K, Zimmerman K, Scholten J, Gelb MH. Differential prenyl pyrophosphate binding to mammalian protein geranylgeranyltransferase-I and protein farnesyltransferase and its consequence on the specificity of protein prenylation. The Journal of Biological Chemistry. 272: 3944-52. PMID 9020098 DOI: 10.1074/Jbc.272.7.3944 |
0.336 |
|
| 1996 |
de Carvalho MG, McCormack AL, Olson E, Ghomashchi F, Gelb MH, Yates JR, Leslie CC. Identification of phosphorylation sites of human 85-kDa cytosolic phospholipase A2 expressed in insect cells and present in human monocytes. The Journal of Biological Chemistry. 271: 6987-97. PMID 8636128 DOI: 10.1074/Jbc.271.12.6987 |
0.335 |
|
| 1995 |
Bayburt T, Yu BZ, Street I, Ghomashchi F, Laliberté F, Perrier H, Wang Z, Homan R, Jain MK, Gelb MH. Continuous, vesicle-based fluorimetric assays of 14- and 85-kDa phospholipases A2. Analytical Biochemistry. 232: 7-23. PMID 8600835 DOI: 10.1006/Abio.1995.9967 |
0.363 |
|
| 1995 |
McIntosh JM, Ghomashchi F, Gelb MH, Dooley DJ, Stoehr SJ, Giordani AB, Naisbitt SR, Olivera BM. Conodipine-M, a novel phospholipase A2 isolated from the venom of the marine snail Conus magus. The Journal of Biological Chemistry. 270: 3518-26. PMID 7876086 DOI: 10.1074/Jbc.270.8.3518 |
0.357 |
|
| 1995 |
Yokoyama K, McGeady P, Gelb MH. Mammalian protein geranylgeranyltransferase-I: substrate specificity, kinetic mechanism, metal requirements, and affinity labeling. Biochemistry. 34: 1344-54. PMID 7827082 DOI: 10.1021/Bi00004A029 |
0.372 |
|
| 1995 |
Glover S, de Carvalho MS, Bayburt T, Jonas M, Chi E, Leslie CC, Gelb MH. Translocation of the 85-kDa phospholipase A2 from cytosol to the nuclear envelope in rat basophilic leukemia cells stimulated with calcium ionophore or IgE/antigen. The Journal of Biological Chemistry. 270: 15359-67. PMID 7797525 DOI: 10.1074/Jbc.270.25.15359 |
0.312 |
|
| 1995 |
Hanel AM, Gelb MH. Multiple enzymatic activities of the human cytosolic 85-kDa phospholipase A2: hydrolytic reactions and acyl transfer to glycerol. Biochemistry. 34: 7807-18. PMID 7794891 DOI: 10.1021/Bi00024A004 |
0.384 |
|
| 1995 |
Jain MK, Gelb MH, Rogers J, Berg OG. Kinetic basis for interfacial catalysis by phospholipase A2. Methods in Enzymology. 249: 567-614. PMID 7791627 DOI: 10.1016/0076-6879(95)49049-3 |
0.348 |
|
| 1995 |
Gelb MH, Tamanoi F, Yokoyama K, Ghomashchi F, Esson K, Gould MN. The inhibition of protein prenyltransferases by oxygenated metabolites of limonene and perillyl alcohol. Cancer Letters. 91: 169-75. PMID 7767906 DOI: 10.1016/0304-3835(95)03747-K |
0.316 |
|
| 1995 |
Gelb MH, Jain MK, Hanel AM, Berg OG. Interfacial enzymology of glycerolipid hydrolases: lessons from secreted phospholipases A2. Annual Review of Biochemistry. 64: 653-88. PMID 7574497 DOI: 10.1146/Annurev.Bi.64.070195.003253 |
0.337 |
|
| 1995 |
Ghomashchi F, Zhang X, Liu L, Gelb MH. Binding of prenylated and polybasic peptides to membranes: affinities and intervesicle exchange. Biochemistry. 34: 11910-8. PMID 7547927 DOI: 10.1021/Bi00037A032 |
0.303 |
|
| 1994 |
Jain MK, Krause CD, Buckley JT, Bayburt T, Gelb MH. Characterization of interfacial catalysis by Aeromonas hydrophila lipase/acyltransferase in the highly processive scooting mode. Biochemistry. 33: 5011-20. PMID 8172876 DOI: 10.1021/Bi00183A003 |
0.364 |
|
| 1994 |
Gelb MH, Jain MK, Berg OG. Inhibition of phospholipase A2. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 8: 916-24. PMID 8088457 DOI: 10.1096/Fasebj.8.12.8088457 |
0.365 |
|
| 1994 |
Farnsworth CC, Seabra MC, Ericsson LH, Gelb MH, Glomset JA. Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A Proceedings of the National Academy of Sciences of the United States of America. 91: 11963-11967. PMID 7991565 DOI: 10.1073/Pnas.91.25.11963 |
0.305 |
|
| 1994 |
James MNG, Sielecki AR, Hayakawa K, Gelb MH. Crystallographic analysis of transition state mimics bound to penicillopepsin: difluorostatine- and difluorostatone-containing peptides. Biochemistry. 31: 3872-3886. DOI: 10.2210/Pdb1Apv/Pdb |
0.349 |
|
| 1993 |
Hanel AM, Schüttel S, Gelb MH. Processive interfacial catalysis by mammalian 85-kilodalton phospholipase A2 enzymes on product-containing vesicles: application to the determination of substrate preferences. Biochemistry. 32: 5949-58. PMID 8507635 DOI: 10.1021/Bi00074A005 |
0.376 |
|
| 1993 |
Bayburt T, Yu BZ, Lin HK, Browning J, Jain MK, Gelb MH. Human nonpancreatic secreted phospholipase A2: interfacial parameters, substrate specificities, and competitive inhibitors. Biochemistry. 32: 573-82. PMID 8422368 DOI: 10.1021/Bi00053A024 |
0.398 |
|
| 1993 |
Street IP, Lin HK, Laliberté F, Ghomashchi F, Wang Z, Perrier H, Tremblay NM, Huang Z, Weech PK, Gelb MH. Slow- and tight-binding inhibitors of the 85-kDa human phospholipase A2. Biochemistry. 32: 5935-40. PMID 8018213 DOI: 10.1021/Bi00074A003 |
0.432 |
|
| 1993 |
Dudler T, Chen WQ, Wang S, Schneider T, Annand RR, Dempcy RO, Crameri R, Gmachl M, Suter M, Gelb MH. High-level expression in Escherichia coli and rapid purification of enzymatically active honey bee venom phospholipase A2. Biochimica Et Biophysica Acta. 1165: 201-10. PMID 1450215 DOI: 10.1016/0005-2760(92)90188-2 |
0.373 |
|
| 1993 |
Lin HK, Gelb MH. Competitive inhibition of interfacial catalysis by phospholipase A2: differential interaction of inhibitors with the vesicle interface as a controlling factor of inhibitor potency Journal of the American Chemical Society. 115: 3932-3942. DOI: 10.1021/Ja00063A012 |
0.397 |
|
| 1992 |
Ghomashchi F, Schüttel S, Jain MK, Gelb MH. Kinetic analysis of a high molecular weight phospholipase A2 from rat kidney: divalent metal-dependent trapping of enzyme on product-containing vesicles. Biochemistry. 31: 3814-24. PMID 1567837 DOI: 10.1021/Bi00130A012 |
0.352 |
|
| 1992 |
Gelb MH, Jain MK, Berg O. Interfacial enzymology of phospholipase A2 Bioorganic & Medicinal Chemistry Letters. 2: 1335-1342. DOI: 10.1016/S0960-894X(00)80508-9 |
0.342 |
|
| 1991 |
Yokoyama K, Goodwin GW, Ghomashchi F, Glomset JA, Gelb MH. A protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificity. Proceedings of the National Academy of Sciences of the United States of America. 88: 5302-6. PMID 2052607 DOI: 10.1073/Pnas.88.12.5302 |
0.301 |
|
| 1991 |
Jain MK, Gelb MH. Phospholipase A2-catalyzed hydrolysis of vesicles: uses of interfacial catalysis in the scooting mode. Methods in Enzymology. 197: 112-25. PMID 2051908 DOI: 10.1016/0076-6879(91)97138-O |
0.319 |
|
| 1991 |
Scott DL, White SP, Browning JL, Rosa JJ, Gelb MH, Sigler PB. Structures of free and inhibited human secretory phospholipase A2 from inflammatory exudate. Science (New York, N.Y.). 254: 1007-10. PMID 1948070 DOI: 10.1126/Science.1948070 |
0.359 |
|
| 1991 |
Ghomashchi F, Yu BZ, Mihelich ED, Jain MK, Gelb MH. Kinetic characterization of phospholipase A2 modified by manoalogue. Biochemistry. 30: 9559-69. PMID 1911741 DOI: 10.1021/Bi00104A001 |
0.385 |
|
| 1991 |
Farnsworth CC, Kawata M, Yoshida Y, Takai Y, Gelb MH, Glomset JA. C terminus of the small GTP-binding protein smg p25A contains two geranylgeranylated cysteine residues and a methyl ester Proceedings of the National Academy of Sciences of the United States of America. 88: 6196-6200. PMID 1906176 DOI: 10.1073/Pnas.88.14.6196 |
0.321 |
|
| 1991 |
Yamane HK, Farnsworth CC, Xie HY, Evans T, Howald WN, Gelb MH, Glomset JA, Clarke S, Fung BK. Membrane-binding domain of the small G protein G25K contains an S-(all-trans-geranylgeranyl)cysteine methyl ester at its carboxyl terminus. Proceedings of the National Academy of Sciences of the United States of America. 88: 286-90. PMID 1898776 DOI: 10.1073/Pnas.88.1.286 |
0.309 |
|
| 1991 |
Jain MK, Rogers J, Berg O, Gelb MH. Interfacial catalysis by phospholipase A2: activation by substrate replenishment. Biochemistry. 30: 7340-8. PMID 1854742 DOI: 10.1021/Bi00243A039 |
0.365 |
|
| 1991 |
Ghomashchi F, Yu BZ, Berg O, Jain MK, Gelb MH. Interfacial catalysis by phospholipase A2: substrate specificity in vesicles. Biochemistry. 30: 7318-29. PMID 1854740 DOI: 10.1021/Bi00243A037 |
0.368 |
|
| 1991 |
Ghomashchi F, O'Hare T, Clary D, Gelb MH. Interfacial catalysis by phospholipase A2: evaluation of the interfacial rate constants by steady-state isotope effect studies. Biochemistry. 30: 7298-305. PMID 1854738 DOI: 10.1021/Bi00243A035 |
0.339 |
|
| 1991 |
Gelb MH, Berg O, Jain MK. Quantitative and structural analysis of inhibitors of phospholipase A2 Current Opinion in Structural Biology. 1: 836-843. DOI: 10.1016/0959-440X(91)90187-X |
0.36 |
|
| 1990 |
Yuan W, Quinn DM, Sigler PB, Gelb MH. Kinetic and inhibition studies of phospholipase A2 with short-chain substrates and inhibitors. Biochemistry. 29: 6082-94. PMID 2383571 DOI: 10.1021/Bi00477A028 |
0.396 |
|
| 1990 |
Farnsworth CC, Gelb MH, Glomset JA. Identification of geranylgeranyl-modified proteins in HeLa cells Science. 247: 320-322. PMID 2296721 DOI: 10.1126/Science.2296721 |
0.321 |
|
| 1990 |
Scott DL, Otwinowski Z, Gelb MH, Sigler PB. Crystal structure of bee-venom phospholipase A2 in a complex with a transition-state analogue. Science (New York, N.Y.). 250: 1563-6. PMID 2274788 DOI: 10.1126/Science.2274788 |
0.323 |
|
| 1990 |
Scott DL, White SP, Otwinowski Z, Yuan W, Gelb MH, Sigler PB. Interfacial catalysis: the mechanism of phospholipase A2. Science (New York, N.Y.). 250: 1541-6. PMID 2274785 DOI: 10.1126/Science.2274785 |
0.375 |
|
| 1990 |
Farnsworth CC, Casey PJ, Howald WN, Glomset JA, Gelb MH. Structural characterization of prenyl groups attached to proteins Methods. 1: 231-240. DOI: 10.1016/S1046-2023(05)80322-6 |
0.314 |
|
| 1989 |
Jain MK, Yuan W, Gelb MH. Competitive inhibition of phospholipase A2 in vesicles. Biochemistry. 28: 4135-9. PMID 2765476 DOI: 10.1021/Bi00436A002 |
0.383 |
|
| 1988 |
Yuan W, Gelb MH. Phosphonate-containing phospholipid analogs as tight-binding inhibitors of phospholipase-A2 Journal of the American Chemical Society. 110: 2665-2666. DOI: 10.1021/Ja00216A059 |
0.338 |
|
| 1987 |
Fearon K, Spaltenstein A, Hopkins PB, Gelb MH. Fluoro ketone containing peptides as inhibitors of human renin. Journal of Medicinal Chemistry. 30: 1617-22. PMID 3305947 DOI: 10.1021/Jm00392A016 |
0.327 |
|
| 1986 |
Gelb MH, Abeles RH. Substituted isatoic anhydrides: selective inactivators of trypsin-like serine proteases. Journal of Medicinal Chemistry. 29: 585-9. PMID 3514913 DOI: 10.1002/Chin.198649216 |
0.597 |
|
| 1986 |
Ringe D, Mottonen JM, Gelb MH, Abeles RH. X-ray diffraction analysis of the inactivation of chymotrypsin by 3-benzyl-6-chloro-2-pyrone. Biochemistry. 25: 5633-8. PMID 3096374 DOI: 10.1021/Bi00367A043 |
0.607 |
|
| 1986 |
Gelb MH. Fluoro ketone phospholipid analogs: new inhibitors of phospholipase A2 Journal of the American Chemical Society. 108: 3146-3147. DOI: 10.1002/Chin.198641335 |
0.317 |
|
| 1985 |
Ringe D, Seaton BA, Gelb MH, Abeles RH. Inactivation of chymotrypsin by 5-benzyl-6-chloro-2-pyrone: 13C NMR and X-ray diffraction analyses of the inactivator-enzyme complex. Biochemistry. 24: 64-8. PMID 3994973 DOI: 10.1021/Bi00322A011 |
0.594 |
|
| 1985 |
Gelb MH, Svaren JP, Abeles RH. Fluoro ketone inhibitors of hydrolytic enzymes. Biochemistry. 24: 1813-7. PMID 2990541 DOI: 10.1021/Bi00329A001 |
0.618 |
|
| 1984 |
Gelb MH, Abeles RH. Mechanism of inactivation of chymotrypsin by 3-benzyl-6-chloro-2-pyrone. Biochemistry. 23: 6596-604. PMID 6529572 DOI: 10.1021/Bi00321A049 |
0.592 |
|
| 1984 |
Sligar SG, Gelb MH, Heimbrook DC. Bio-organic chemistry and cytochrome P-450-dependent catalysis. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 14: 63-86. PMID 6372267 DOI: 10.3109/00498258409151399 |
0.383 |
|
| 1982 |
Gelb MH, Heimbrook DC, Mälkönen P, Sligar SG. Stereochemistry and deuterium isotope effects in camphor hydroxylation by the cytochrome P450cam monoxygenase system. Biochemistry. 21: 370-7. PMID 7074020 DOI: 10.1021/Bi00531A026 |
0.466 |
|
| 1982 |
Gelb MH, Malkonen P, Sligar SG. Cytochrome P450cam catalyzed epoxidation of dehydrocamphor. Biochemical and Biophysical Research Communications. 104: 853-8. PMID 7073732 DOI: 10.1016/0006-291X(82)91327-4 |
0.485 |
|
| 1982 |
Gelb MH, Toscano WA, Sligar SG. Chemical mechanisms for cytochrome P-450 oxidation: spectral and catalytic properties of a manganese-substituted protein. Proceedings of the National Academy of Sciences of the United States of America. 79: 5758-62. PMID 6964386 DOI: 10.1073/Pnas.79.19.5758 |
0.503 |
|
| 1982 |
Gelb M, Heimbrook D, Malkonen P, Sligar S. Corrections - Stereochemistry and Deuterium Effects in Camphor Hydroxylation by the Cytochrome P450cam Monoxygenase System Biochemistry. 21: 3036-3036. DOI: 10.1021/Bi00541A607 |
0.456 |
|
| 1981 |
Gould PV, Gelb MH, Sligar SG. Interaction of 5-bromocamphor with cytochrome P-450 cam. Production of 5-ketocamphor from a mixed spin state hemoprotein. The Journal of Biological Chemistry. 256: 6686-91. PMID 7240237 |
0.409 |
|
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