| Year |
Citation |
Score |
| 2023 |
Marathe N, Nguyen HA, Alumasa JN, Kuzmishin Nagy AB, Vazquez M, Dunham CM, Keiler KC. Antibiotic that inhibits -translation blocks binding of EF-Tu to tmRNA but not to tRNA. Mbio. e0146123. PMID 37681945 DOI: 10.1128/mbio.01461-23 |
0.321 |
|
| 2022 |
Srinivas P, Keiler KC, Dunham CM. Druggable differences: Targeting mechanistic differences between trans-translation and translation for selective antibiotic action. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. e2200046. PMID 35719031 DOI: 10.1002/bies.202200046 |
0.311 |
|
| 2021 |
Aron ZD, Mehrani A, Hoffer ED, Connolly KL, Srinivas P, Torhan MC, Alumasa JN, Cabrera M, Hosangadi D, Barbor JS, Cardinale SC, Kwasny SM, Morin LR, Butler MM, Opperman TJ, ... ... Keiler KC, et al. trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo. Nature Communications. 12: 1799. PMID 33741965 DOI: 10.1038/s41467-021-22012-7 |
0.304 |
|
| 2019 |
Huang Y, Alumasa JN, Callaghan LT, Baugh RS, Rae CD, Keiler KC, McGillivray SM. A Small-Molecule Inhibitor of -Translation Synergistically Interacts with Cathelicidin Antimicrobial Peptides To Impair Survival of Staphylococcus aureus. Antimicrobial Agents and Chemotherapy. 63. PMID 30917982 DOI: 10.1128/Aac.02362-18 |
0.362 |
|
| 2019 |
Mehrani A, Hoffer ED, Goralski TD, Keiler KC, Dunham CM, Stagg S. Investigating the Structural Mechanism of the Stalled Bacterial Ribosome Bound to a Drug that Targets Trans-Translation Biophysical Journal. 116: 573a-574a. DOI: 10.1016/J.Bpj.2018.11.3085 |
0.303 |
|
| 2018 |
Goralski TDP, Kirimanjeswara GS, Keiler KC. A New Mechanism for Ribosome Rescue Can Recruit RF1 or RF2 to Nonstop Ribosomes. Mbio. 9. PMID 30563899 DOI: 10.1128/Mbio.02436-18 |
0.391 |
|
| 2018 |
Simonson AW, Lawanprasert A, Goralski TDP, Keiler KC, Medina SH. Bioresponsive peptide-polysaccharide nanogels - A versatile delivery system to augment the utility of bioactive cargo. Nanomedicine : Nanotechnology, Biology, and Medicine. PMID 30399437 DOI: 10.1016/J.Nano.2018.10.008 |
0.36 |
|
| 2017 |
Alumasa JN, Manzanillo PS, Peterson ND, Lundrigan T, Baughn AD, Cox JS, Keiler KC. Ribosome Rescue Inhibitors Kill Actively Growing and Non-replicating Persister Mycobacterium tuberculosis Cells. Acs Infectious Diseases. PMID 28762275 DOI: 10.1021/Acsinfecdis.7B00028 |
0.315 |
|
| 2017 |
Alumasa JN, Goralski TDP, Keiler KC. Tetrazole-Based trans-Translation Inhibitors Kill Bacillus anthracis Spores to Protect Host Cells. Antimicrobial Agents and Chemotherapy. PMID 28760903 DOI: 10.1128/Aac.01199-17 |
0.309 |
|
| 2017 |
Dillon NA, Peterson ND, Feaga HA, Keiler KC, Baughn AD. Anti-tubercular Activity of Pyrazinamide is Independent of trans-Translation and RpsA. Scientific Reports. 7: 6135. PMID 28733601 DOI: 10.1038/S41598-017-06415-5 |
0.37 |
|
| 2016 |
Feaga HA, Quickel MD, Hankey-Giblin PA, Keiler KC. Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria. Plos Genetics. 12: e1005964. PMID 27029019 DOI: 10.1371/Journal.Pgen.1005964 |
0.427 |
|
| 2016 |
Goralski TD, Dewan KK, Alumasa JN, Avanzato V, Place DE, Markley RL, Katkere B, Rabadi SM, Bakshi CS, Keiler KC, Kirimanjeswara GS. Inhibitors of ribosome rescue arrest growth of Francisella tularensis at all stages of intracellular replication. Antimicrobial Agents and Chemotherapy. PMID 26953190 DOI: 10.1128/Aac.03089-15 |
0.352 |
|
| 2015 |
Alumasa JN, Keiler KC. Clicking on trans-translation drug targets. Frontiers in Microbiology. 6: 498. PMID 26042115 DOI: 10.3389/Fmicb.2015.00498 |
0.319 |
|
| 2015 |
Keiler KC. Mechanisms of ribosome rescue in bacteria. Nature Reviews. Microbiology. 13: 285-97. PMID 25874843 DOI: 10.1038/Nrmicro3438 |
0.422 |
|
| 2015 |
El-Mowafi SA, Sineva E, Alumasa JN, Nicoloff H, Tomsho JW, Ades SE, Keiler KC. Identification of inhibitors of a bacterial sigma factor using a new high-throughput screening assay. Antimicrobial Agents and Chemotherapy. 59: 193-205. PMID 25331704 DOI: 10.1128/Aac.03979-14 |
0.384 |
|
| 2014 |
Feaga HA, Viollier PH, Keiler KC. Release of nonstop ribosomes is essential. Mbio. 5: e01916. PMID 25389176 DOI: 10.1128/Mbio.01916-14 |
0.432 |
|
| 2014 |
El-Mowafi SA, Alumasa JN, Ades SE, Keiler KC. Cell-based assay to identify inhibitors of the Hfq-sRNA regulatory pathway. Antimicrobial Agents and Chemotherapy. 58: 5500-9. PMID 25001303 DOI: 10.1128/Aac.03311-14 |
0.469 |
|
| 2014 |
Keiler KC, Feaga HA. Resolving nonstop translation complexes is a matter of life or death. Journal of Bacteriology. 196: 2123-30. PMID 24706739 DOI: 10.1128/Jb.01490-14 |
0.38 |
|
| 2013 |
Keiler KC, Alumasa JN. The potential of trans-translation inhibitors as antibiotics. Future Microbiology. 8: 1235-7. PMID 24059913 DOI: 10.2217/Fmb.13.110 |
0.312 |
|
| 2013 |
Ramadoss NS, Alumasa JN, Cheng L, Wang Y, Li S, Chambers BS, Chang H, Chatterjee AK, Brinker A, Engels IH, Keiler KC. Small molecule inhibitors of trans-translation have broad-spectrum antibiotic activity. Proceedings of the National Academy of Sciences of the United States of America. 110: 10282-7. PMID 23733947 DOI: 10.1073/Pnas.1302816110 |
0.384 |
|
| 2013 |
Ramadoss NS, Zhou X, Keiler KC. tmRNA is essential in Shigella flexneri. Plos One. 8: e57537. PMID 23451240 DOI: 10.1371/Journal.Pone.0057537 |
0.387 |
|
| 2012 |
Russell JH, Keiler KC. RNA visualization in bacteria by fluorescence in situ hybridization. Methods in Molecular Biology (Clifton, N.J.). 905: 87-95. PMID 22736000 DOI: 10.1007/978-1-61779-949-5_7 |
0.386 |
|
| 2012 |
McGillivray SM, Tran DN, Ramadoss NS, Alumasa JN, Okumura CY, Sakoulas G, Vaughn MM, Zhang DX, Keiler KC, Nizet V. Pharmacological inhibition of the ClpXP protease increases bacterial susceptibility to host cathelicidin antimicrobial peptides and cell envelope-active antibiotics. Antimicrobial Agents and Chemotherapy. 56: 1854-61. PMID 22252821 DOI: 10.1128/Aac.05131-11 |
0.388 |
|
| 2011 |
Keiler KC. Localization of the bacterial RNA infrastructure. Advances in Experimental Medicine and Biology. 722: 231-8. PMID 21915793 DOI: 10.1007/978-1-4614-0332-6_15 |
0.413 |
|
| 2011 |
Keiler KC, Ramadoss NS. Bifunctional transfer-messenger RNA. Biochimie. 93: 1993-7. PMID 21664408 DOI: 10.1016/J.Biochi.2011.05.029 |
0.46 |
|
| 2011 |
Keiler KC. RNA localization in bacteria. Current Opinion in Microbiology. 14: 155-9. PMID 21354362 DOI: 10.1016/J.Mib.2011.01.009 |
0.432 |
|
| 2010 |
Hughes HV, Huitema E, Pritchard S, Keiler KC, Brun YV, Viollier PH. Protein localization and dynamics within a bacterial organelle. Proceedings of the National Academy of Sciences of the United States of America. 107: 5599-604. PMID 20212131 DOI: 10.1073/Pnas.0909119107 |
0.313 |
|
| 2010 |
Hayes CS, Keiler KC. Beyond ribosome rescue: tmRNA and co-translational processes. Febs Letters. 584: 413-9. PMID 19914241 DOI: 10.1016/J.Febslet.2009.11.023 |
0.45 |
|
| 2009 |
Russell JH, Keiler KC. Subcellular localization of a bacterial regulatory RNA. Proceedings of the National Academy of Sciences of the United States of America. 106: 16405-9. PMID 19805312 DOI: 10.1073/Pnas.0904904106 |
0.464 |
|
| 2009 |
Cheng L, Keiler KC. Correct timing of dnaA transcription and initiation of DNA replication requires trans translation. Journal of Bacteriology. 191: 4268-75. PMID 19429626 DOI: 10.1128/Jb.00362-09 |
0.382 |
|
| 2008 |
Keiler KC. Biology of trans-translation. Annual Review of Microbiology. 62: 133-51. PMID 18557701 DOI: 10.1146/Annurev.Micro.62.081307.162948 |
0.395 |
|
| 2008 |
Russell JH, Keiler KC. Screen for localized proteins in Caulobacter crescentus. Plos One. 3: e1756. PMID 18335033 DOI: 10.1371/Journal.Pone.0001756 |
0.382 |
|
| 2007 |
Hong SJ, Lessner FH, Mahen EM, Keiler KC. Proteomic identification of tmRNA substrates. Proceedings of the National Academy of Sciences of the United States of America. 104: 17128-33. PMID 17940001 DOI: 10.1073/Pnas.0707671104 |
0.676 |
|
| 2007 |
Russell JH, Keiler KC. Peptide signals encode protein localization. Journal of Bacteriology. 189: 7581-5. PMID 17766408 DOI: 10.1128/Jb.00981-07 |
0.388 |
|
| 2007 |
Cheng L, Naumann TA, Horswill AR, Hong SJ, Venters BJ, Tomsho JW, Benkovic SJ, Keiler KC. Discovery of antibacterial cyclic peptides that inhibit the ClpXP protease. Protein Science : a Publication of the Protein Society. 16: 1535-42. PMID 17600141 DOI: 10.1110/Ps.072933007 |
0.669 |
|
| 2007 |
Keiler KC. Physiology of tmRNA: what gets tagged and why? Current Opinion in Microbiology. 10: 169-75. PMID 17383929 DOI: 10.1016/J.Mib.2007.03.014 |
0.463 |
|
| 2007 |
Lessner FH, Venters BJ, Keiler KC. Proteolytic adaptor for transfer-messenger RNA-tagged proteins from alpha-proteobacteria. Journal of Bacteriology. 189: 272-5. PMID 17085560 DOI: 10.1128/Jb.01387-06 |
0.428 |
|
| 2005 |
Hong SJ, Tran QA, Keiler KC. Cell cycle-regulated degradation of tmRNA is controlled by RNase R and SmpB. Molecular Microbiology. 57: 565-75. PMID 15978085 DOI: 10.1111/J.1365-2958.2005.04709.X |
0.675 |
|
| 2003 |
Keiler KC, Shapiro L. tmRNA in Caulobacter crescentus is cell cycle regulated by temporally controlled transcription and RNA degradation. Journal of Bacteriology. 185: 1825-30. PMID 12618446 DOI: 10.1128/Jb.185.6.1825-1830.2003 |
0.417 |
|
| 2003 |
Keiler KC, Shapiro L. TmRNA is required for correct timing of DNA replication in Caulobacter crescentus. Journal of Bacteriology. 185: 573-80. PMID 12511504 DOI: 10.1128/Jb.185.2.573-580.2003 |
0.43 |
|
| 2001 |
Keiler KC, Shapiro L. Conserved promoter motif is required for cell cycle timing of dnaX transcription in Caulobacter. Journal of Bacteriology. 183: 4860-5. PMID 11466289 DOI: 10.1128/Jb.183.16.4860-4865.2001 |
0.348 |
|
| 2000 |
Keiler KC, Shapiro L, Williams KP. tmRNAs that encode proteolysis-inducing tags are found in all known bacterial genomes: A two-piece tmRNA functions in caulobacter Proceedings of the National Academy of Sciences of the United States of America. 97: 7778-7783. PMID 10884408 DOI: 10.1073/Pnas.97.14.7778 |
0.432 |
|
| 1996 |
Keiler KC, Waller PRH, Sauer RT. Role of a peptide tagging system in degradation of proteins synthesized from damaged messenger RNA Science. 271: 990-993. PMID 8584937 DOI: 10.1126/Science.271.5251.990 |
0.478 |
|
| 1996 |
Keiler KC, Sauer RT. Sequence determinants of C-terminal substrate recognition by the Tsp protease Journal of Biological Chemistry. 271: 2589-2593. PMID 8576225 DOI: 10.1074/Jbc.271.5.2589 |
0.353 |
|
| 1995 |
Keiler KC, Silber KR, Downard KM, Papayannopoulos IA, Biemann K, Sauer RT. C-terminal specific protein degradation: activity and substrate specificity of the Tsp protease. Protein Science : a Publication of the Protein Society. 4: 1507-15. PMID 8520476 DOI: 10.1002/Pro.5560040808 |
0.4 |
|
| 1995 |
Keiler KC, Sauer RT. Identification of active site residues of the Tsp protease Journal of Biological Chemistry. 270: 28864-28868. PMID 7499412 DOI: 10.1074/Jbc.270.48.28864 |
0.361 |
|
| 1992 |
Silber KR, Keiler KC, Sauer RT. Tsp: A tail-specific protease that selectively degrades proteins with nonpolar C termini Proceedings of the National Academy of Sciences of the United States of America. 89: 295-299. PMID 1729701 DOI: 10.1073/Pnas.89.1.295 |
0.343 |
|
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