| Year |
Citation |
Score |
| 2016 |
Mahalingan KK, Baskaran S, Depaoli-Roach AA, Roach PJ, Hurley TD. Redox switch for the inhibited state of yeast glycogen synthase mimics regulation by phosphorylation. Biochemistry. PMID 27935293 DOI: 10.1021/Acs.Biochem.6B00884 |
0.369 |
|
| 2015 |
Morgan CA, Hurley TD. Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors. Journal of Medicinal Chemistry. 58: 1964-75. PMID 25634381 DOI: 10.1021/Jm501900S |
0.327 |
|
| 2015 |
Morgan CA, Parajuli B, Buchman CD, Dria K, Hurley TD. N,N-diethylaminobenzaldehyde (DEAB) as a substrate and mechanism-based inhibitor for human ALDH isoenzymes. Chemico-Biological Interactions. 234: 18-28. PMID 25512087 DOI: 10.1016/J.Cbi.2014.12.008 |
0.303 |
|
| 2015 |
Morgan CA, Hurley TD. Development of a high-throughput in vitro assay to identify selective inhibitors for human ALDH1A1. Chemico-Biological Interactions. 234: 29-37. PMID 25450233 DOI: 10.1016/J.Cbi.2014.10.028 |
0.338 |
|
| 2014 |
Kimble-Hill AC, Parajuli B, Chen CH, Mochly-Rosen D, Hurley TD. Development of selective inhibitors for aldehyde dehydrogenases based on substituted indole-2,3-diones. Journal of Medicinal Chemistry. 57: 714-22. PMID 24444054 DOI: 10.1021/Jm401377V |
0.322 |
|
| 2013 |
González-Segura L, Ho KK, Perez-Miller S, Weiner H, Hurley TD. Catalytic contribution of threonine 244 in human ALDH2. Chemico-Biological Interactions. 202: 32-40. PMID 23295226 DOI: 10.1016/J.Cbi.2012.12.009 |
0.374 |
|
| 2012 |
Koppaka V, Thompson DC, Chen Y, Ellermann M, Nicolaou KC, Juvonen RO, Petersen D, Deitrich RA, Hurley TD, Vasiliou V. Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application. Pharmacological Reviews. 64: 520-39. PMID 22544865 DOI: 10.1124/Pr.111.005538 |
0.315 |
|
| 2011 |
Khanna M, Chen CH, Kimble-Hill A, Parajuli B, Perez-Miller S, Baskaran S, Kim J, Dria K, Vasiliou V, Mochly-Rosen D, Hurley TD. Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases. The Journal of Biological Chemistry. 286: 43486-94. PMID 22021038 DOI: 10.1074/Jbc.M111.293597 |
0.387 |
|
| 2011 |
Liu JY, Hurley TD. A new crystal form of mouse thiamin pyrophosphokinase. International Journal of Biochemistry and Molecular Biology. 2: 111-8. PMID 21552434 |
0.43 |
|
| 2010 |
Allen EM, Anderson DG, Florang VR, Khanna M, Hurley TD, Doorn JA. Relative inhibitory potency of molinate and metabolites with aldehyde dehydrogenase 2: implications for the mechanism of enzyme inhibition. Chemical Research in Toxicology. 23: 1843-50. PMID 20954713 DOI: 10.1021/Tx100317Q |
0.325 |
|
| 2010 |
Baskaran S, Roach PJ, DePaoli-Roach AA, Hurley TD. Structural basis for glucose-6-phosphate activation of glycogen synthase. Proceedings of the National Academy of Sciences of the United States of America. 107: 17563-8. PMID 20876143 DOI: 10.1073/Pnas.1006340107 |
0.313 |
|
| 2010 |
Perez-Miller S, Younus H, Vanam R, Chen CH, Mochly-Rosen D, Hurley TD. Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant. Nature Structural & Molecular Biology. 17: 159-64. PMID 20062057 DOI: 10.1038/Nsmb.1737 |
0.349 |
|
| 2007 |
González-Segura L, Witte JF, McClard RW, Hurley TD. Ternary complex formation and induced asymmetry in orotate phosphoribosyltransferase. Biochemistry. 46: 14075-86. PMID 18020427 DOI: 10.1021/Bi701023Z |
0.376 |
|
| 2007 |
Hurley TD, Yang J, Zhang L, Goodwin KD, Zou Q, Cortese M, Dunker AK, DePaoli-Roach AA. Structural basis for regulation of protein phosphatase 1 by inhibitor-2. The Journal of Biological Chemistry. 282: 28874-83. PMID 17636256 DOI: 10.1074/Jbc.M703472200 |
0.312 |
|
| 2007 |
Larson HN, Zhou J, Chen Z, Stamler JS, Weiner H, Hurley TD. Structural and functional consequences of coenzyme binding to the inactive asian variant of mitochondrial aldehyde dehydrogenase: roles of residues 475 and 487. The Journal of Biological Chemistry. 282: 12940-50. PMID 17327228 DOI: 10.1074/Jbc.M607959200 |
0.41 |
|
| 2007 |
Bateman RL, Ashworth J, Witte JF, Baker LJ, Bhanumoorthy P, Timm DE, Hurley TD, Grompe M, McClard RW. Slow-onset inhibition of fumarylacetoacetate hydrolase by phosphinate mimics of the tetrahedral intermediate: kinetics, crystal structure and pharmacokinetics. The Biochemical Journal. 402: 251-60. PMID 17064256 DOI: 10.1042/Bj20060961 |
0.352 |
|
| 2006 |
Doorn JA, Hurley TD, Petersen DR. Inhibition of human mitochondrial aldehyde dehydrogenase by 4-hydroxynon-2-enal and 4-oxonon-2-enal. Chemical Research in Toxicology. 19: 102-10. PMID 16411662 DOI: 10.1021/Tx0501839 |
0.36 |
|
| 2006 |
Liu JY, Timm DE, Hurley TD. Pyrithiamine as a substrate for thiamine pyrophosphokinase. The Journal of Biological Chemistry. 281: 6601-7. PMID 16365036 DOI: 10.1074/Jbc.M510951200 |
0.435 |
|
| 2005 |
Larson HN, Weiner H, Hurley TD. Disruption of the coenzyme binding site and dimer interface revealed in the crystal structure of mitochondrial aldehyde dehydrogenase "Asian" variant. The Journal of Biological Chemistry. 280: 30550-6. PMID 15983043 DOI: 10.1074/Jbc.M502345200 |
0.421 |
|
| 2005 |
Hurley TD, Stout S, Miner E, Zhou J, Roach PJ. Requirements for catalysis in mammalian glycogenin. The Journal of Biological Chemistry. 280: 23892-9. PMID 15849187 DOI: 10.1074/Jbc.M502344200 |
0.347 |
|
| 2003 |
Perez-Miller SJ, Hurley TD. Coenzyme isomerization is integral to catalysis in aldehyde dehydrogenase. Biochemistry. 42: 7100-9. PMID 12795606 DOI: 10.1021/Bi034182W |
0.42 |
|
| 2002 |
Sanghani PC, Bosron WF, Hurley TD. Human glutathione-dependent formaldehyde dehydrogenase. Structural changes associated with ternary complex formation. Biochemistry. 41: 15189-94. PMID 12484756 DOI: 10.1021/Bi026705Q |
0.358 |
|
| 2002 |
Sanghani PC, Robinson H, Bosron WF, Hurley TD. Human glutathione-dependent formaldehyde dehydrogenase. Structures of apo, binary, and inhibitory ternary complexes. Biochemistry. 41: 10778-86. PMID 12196016 DOI: 10.1021/Bi0257639 |
0.41 |
|
| 2002 |
Gibbons BJ, Roach PJ, Hurley TD. Crystal structure of the autocatalytic initiator of glycogen biosynthesis, glycogenin. Journal of Molecular Biology. 319: 463-77. PMID 12051921 DOI: 10.1016/S0022-2836(02)00305-4 |
0.34 |
|
| 2002 |
Hammen PK, Allali-Hassani A, Hallenga K, Hurley TD, Weiner H. Multiple conformations of NAD and NADH when bound to human cytosolic and mitochondrial aldehyde dehydrogenase. Biochemistry. 41: 7156-68. PMID 12033950 DOI: 10.1021/Bi012197T |
0.368 |
|
| 2001 |
Hurley TD, Perez-Miller S, Breen H. Order and disorder in mitochondrial aldehyde dehydrogenase Chemico-Biological Interactions. 130: 3-14. PMID 11306026 DOI: 10.1016/S0009-2797(00)00217-9 |
0.371 |
|
| 2001 |
Niederhut MS, Gibbons BJ, Perez-Miller S, Hurley TD. Three-dimensional structures of the three human class I alcohol dehydrogenases. Protein Science : a Publication of the Protein Society. 10: 697-706. PMID 11274460 DOI: 10.1110/Ps.45001 |
0.339 |
|
| 2000 |
Sanghani PC, Stone CL, Ray BD, Pindel EV, Hurley TD, Bosron WF. Kinetic mechanism of human glutathione-dependent formaldehyde dehydrogenase Biochemistry. 39: 10720-10729. PMID 10978156 DOI: 10.1021/Bi9929711 |
0.396 |
|
| 2000 |
Wei B, Ni L, Hurley TD, Weiner H. Cooperativity in nicotinamide adenine dinucleotide binding induced by mutations of arginine 475 located at the subunit interface in the human liver mitochondrial class 2 aldehyde dehydrogenase Biochemistry. 39: 5295-5302. PMID 10819999 DOI: 10.1021/Bi000028N |
0.327 |
|
| 1999 |
Ni L, Zhou J, Hurley TD, Weiner H. Human liver mitochondrial aldehyde dehydrogenase: three-dimensional structure and the restoration of solubility and activity of chimeric forms. Protein Science : a Publication of the Protein Society. 8: 2784-90. PMID 10631996 DOI: 10.1110/Ps.8.12.2784 |
0.333 |
|
| 1999 |
Xie PT, Hurley TD. Methionine-141 directly influences the binding of 4-methylpyrazole in human σσ alcohol dehydrogenase Protein Science. 8: 2639-2644. PMID 10631979 DOI: 10.1110/Ps.8.12.2639 |
0.354 |
|
| 1999 |
Hurley TD, Steinmetz CG, Weiner H. Three-dimensional structure of mitochondrial aldehyde dehydrogenase: Mechanistic implications Advances in Experimental Medicine and Biology. 463: 15-25. PMID 10352665 DOI: 10.1007/978-1-4615-4735-8_3 |
0.399 |
|
| 1997 |
Xie P, Parsons SH, Speckhard DC, Bosron WF, Hurley TD. X-ray structure of human class IV σσ alcohol dehydrogenase. Structural basis for substrate specificity Journal of Biological Chemistry. 272: 18558-18563. PMID 9228021 DOI: 10.1074/Jbc.272.30.18558 |
0.39 |
|
| 1997 |
Steinmetz CG, Xie P, Weiner H, Hurley TD. Structure of mitochondrial aldehyde dehydrogenase: The genetic component of ethanol aversion Structure. 5: 701-711. PMID 9195888 DOI: 10.1016/S0969-2126(97)00224-4 |
0.373 |
|
| 1997 |
Yang ZN, Bosron WF, Hurley TD. Structure of human χχ alcohol dehydrogenase: A glutathione-dependent formaldehyde dehydrogenase Journal of Molecular Biology. 265: 330-343. PMID 9018047 DOI: 10.1006/Jmbi.1996.0731 |
0.413 |
|
| 1996 |
Longenecker KL, Roach PJ, Hurley TD. Three-dimensional structure of mammalian casein kinase I: Molecular basis for phosphate recognition Journal of Molecular Biology. 257: 618-631. PMID 8648628 DOI: 10.1006/Jmbi.1996.0189 |
0.316 |
|
| 1994 |
Hurley TD, Bosron WF, Stone CL, Amzel LM. Structures of three human beta alcohol dehydrogenase variants. Correlations with their functional differences. Journal of Molecular Biology. 239: 415-29. PMID 8201622 DOI: 10.1006/Jmbi.1994.1382 |
0.313 |
|
| 1991 |
Hurley TD, Bosron WF, Hamilton JA, Amzel LM. Structure of human beta 1 beta 1 alcohol dehydrogenase: catalytic effects of non-active-site substitutions. Proceedings of the National Academy of Sciences of the United States of America. 88: 8149-53. PMID 1896463 DOI: 10.1073/Pnas.88.18.8149 |
0.31 |
|
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