Gerald Krystal - Publications

Affiliations: 
University of British Columbia, Vancouver, Vancouver, BC, Canada 
Area:
Molecular Biology

134 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Chamberlain TC, Cheung ST, Yoon JSJ, Ming-Lum A, Gardill BR, Shakibakho S, Dzananovic E, Ban F, Samiea A, Jawanda K, Priatel J, Krystal G, Ong CJ, Cherkasov A, Andersen RJ, et al. Interleukin-10 and Small Molecule SHIP1 Allosteric Regulators Trigger Anti-inflammatory Effects through SHIP1/STAT3 Complexes. Iscience. 23: 101433. PMID 32823063 DOI: 10.1016/J.Isci.2020.101433  0.34
2020 Elisia I, Lam V, Cho B, Hay M, Li MY, Kapeluto J, Elliott T, Harris D, Bu L, Jia W, Leung H, Mohn W, Krystal G. Exploratory examination of inflammation state, immune response and blood cell composition in a human obese cohort to identify potential markers predicting cancer risk. Plos One. 15: e0228633. PMID 32027700 DOI: 10.1371/Journal.Pone.0228633  0.312
2019 Aoki T, Chong LC, Takata K, Milne K, Hav M, Colombo A, Chavez EA, Nissen M, Wang X, Miyata-Takata T, Lam V, Vigano E, Woolcock BW, Telenius A, Li MY, ... ... Krystal G, et al. Single cell transcriptome analysis reveals disease-defining T cell subsets in the tumor microenvironment of classic Hodgkin lymphoma. Cancer Discovery. PMID 31857391 DOI: 10.1158/2159-8290.Cd-19-0680  0.354
2019 Ayeni D, Miller B, Kuhlmann A, Ho PC, Robles-Oteiza C, Gaefele M, Levy S, de Miguel FJ, Perry C, Guan T, Krystal G, Lockwood W, Zelterman D, Homer R, Liu Z, et al. Tumor regression mediated by oncogene withdrawal or erlotinib stimulates infiltration of inflammatory immune cells in EGFR mutant lung tumors. Journal For Immunotherapy of Cancer. 7: 172. PMID 31291990 DOI: 10.1186/S40425-019-0643-8  0.313
2019 Samudio I, Hofs E, Cho B, Li M, Bolduc K, Bu L, Liu G, Lam V, Rennie P, Jia W, Elisia I, Krystal G. UV Light-inactivated HSV-1 Stimulates Natural Killer Cell-induced Killing of Prostate Cancer Cells. Journal of Immunotherapy (Hagerstown, Md. : 1997). PMID 30933043 DOI: 10.1097/Cji.0000000000000261  0.437
2017 Elisia I, Lam V, Hofs E, Li MY, Hay M, Cho B, Brooks-Wilson A, Rosin M, Bu L, Jia W, Krystal G. Effect of age on chronic inflammation and responsiveness to bacterial and viral challenges. Plos One. 12: e0188881. PMID 29186188 DOI: 10.1371/Journal.Pone.0188881  0.311
2017 Elisia I, Pae HB, Lam V, Cederberg R, Hofs E, Krystal G. Comparison of RAW264.7, human whole blood and PBMC assays to screen for immunomodulators. Journal of Immunological Methods. PMID 29042255 DOI: 10.1016/J.Jim.2017.10.004  0.342
2016 Ho VW, Hofs E, Elisia I, Lam V, Hsu BE, Lai J, Luk B, Samudio I, Krystal G. All Trans Retinoic Acid, Transforming Growth Factor β and Prostaglandin E2 in Mouse Plasma Synergize with Basophil-Secreted Interleukin-4 to M2 Polarize Murine Macrophages. Plos One. 11: e0168072. PMID 27977740 DOI: 10.1371/Journal.Pone.0168072  0.34
2016 Velez J, Pan R, Lee JT, Enciso L, Suarez M, Duque JE, Jaramillo D, Lopez C, Morales L, Bornmann W, Konopleva M, Krystal G, Andreeff M, Samudio I. Biguanides sensitize leukemia cells to ABT-737-induced apoptosis by inhibiting mitochondrial electron transport. Oncotarget. PMID 27283492 DOI: 10.18632/Oncotarget.9843  0.314
2016 Elisia I, Nakamura H, Lam V, Hofs E, Cederberg R, Cait J, Hughes MR, Lee L, Jia W, Adomat HH, Guns ES, McNagny KM, Samudio I, Krystal G. DMSO Represses Inflammatory Cytokine Production from Human Blood Cells and Reduces Autoimmune Arthritis. Plos One. 11: e0152538. PMID 27031833 DOI: 10.1371/Journal.Pone.0152538  0.386
2016 Samudio I, Rezvani K, Shaim H, Hofs E, Ngom M, Bu L, Liu G, Lee JT, Imren S, Lam V, Poon GF, Ghaedi M, Takei F, Humphries K, Jia W, ... Krystal G, et al. UV-inactivated HSV-1 potently activates NK cell killing of leukemic cells. Blood. PMID 26941401 DOI: 10.1182/Blood-2015-04-639088  0.431
2015 Hamilton MJ, Halvorsen EC, LePard NE, Bosiljcic M, Ho VW, Lam V, Banáth J, Bennewith KL, Krystal G. SHIP represses lung inf lammation and inhibits mammary tumor metastasis in BALB/c mice. Oncotarget. PMID 26683227 DOI: 10.18632/Oncotarget.6611  0.355
2014 Hamilton MJ, Bosiljcic M, Lepard NE, Halvorsen EC, Ho VW, Banáth JP, Krystal G, Bennewith KL. Macrophages are more potent immune suppressors ex vivo than immature myeloid-derived suppressor cells induced by metastatic murine mammary carcinomas. Journal of Immunology (Baltimore, Md. : 1950). 192: 512-22. PMID 24285836 DOI: 10.4049/Jimmunol.1300096  0.379
2013 Rahim MM, Tai LH, Troke AD, Mahmoud AB, Abou-Samra E, Roy JG, Mottashed A, Ault N, Corbeil C, Goulet ML, Zein HS, Hamilton-Valensky M, Krystal G, Kerr WG, Toyama-Sorimachi N, et al. Ly49Q positively regulates type I IFN production by plasmacytoid dendritic cells in an immunoreceptor tyrosine-based inhibitory motif-dependent manner. Journal of Immunology (Baltimore, Md. : 1950). 190: 3994-4004. PMID 23479228 DOI: 10.4049/Jimmunol.1200873  0.427
2013 Hamilton MJ, Bosiljcic M, LePard NE, Harbourne BT, Krystal G, Bennewith KL. Abstract A108: Distinct immune suppressive myeloid cell populations are induced by hypoxic mammary tumors and differentially promote metastatic tumor growth Molecular Cancer Research. 11. DOI: 10.1158/1557-3125.Advbc-A108  0.324
2013 Hamilton MJ, Bosiljcic M, Harbourne BT, LePard NE, Halvorsen EC, Kim AY, Banath JP, Krystal G, Bennewith KL. Abstract A9: Immune suppressive myeloid cells induced by hypoxic mammary tumor cells persist after primary tumor resection and promote metastatic growth Cancer Research. 73. DOI: 10.1158/1538-7445.Tim2013-A9  0.332
2012 Ruschmann J, Antignano F, Lam V, Snyder K, Kim C, Essak M, Zhang A, Lin AH, Mali RS, Kapur R, Krystal G. The role of SHIP in the development and activation of mouse mucosal and connective tissue mast cells. Journal of Immunology (Baltimore, Md. : 1950). 188: 3839-50. PMID 22430739 DOI: 10.4049/Jimmunol.1003875  0.434
2012 Hamilton MJ, Banáth JP, Lam V, Lepard NE, Krystal G, Bennewith KL. Serum inhibits the immunosuppressive function of myeloid-derived suppressor cells isolated from 4T1 tumor-bearing mice. Cancer Immunology, Immunotherapy : Cii. 61: 643-54. PMID 22021068 DOI: 10.1007/S00262-011-1125-0  0.344
2012 Meimetis LG, Nodwell M, Yang L, Wang X, Wu J, Harwig C, Stenton GR, MacKenzie LF, MacRury T, Patrick BO, Ming-Lum A, Ong CJ, Krystal G, Mui ALF, Andersen RJ. Synthesis of SHIP1-activating analogs of the sponge meroterpenoid pelorol European Journal of Organic Chemistry. 5195-5207. DOI: 10.1002/Ejoc.201200631  0.351
2011 Ma P, Mali RS, Munugalavadla V, Krishnan S, Ramdas B, Sims E, Martin H, Ghosh J, Li S, Chan RJ, Krystal G, Craig AW, Takemoto C, Kapur R. The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor. Blood. 118: 3459-69. PMID 21791431 DOI: 10.1182/Blood-2011-04-351809  0.478
2011 Antignano F, Hamilton M, Patterson S, Ho V, Cohen C, Levings MK, Krystal G. SHIP-deficient dendritic cells, unlike wild type dendritic cells, suppress T cell proliferation via a nitric oxide-independent mechanism. Plos One. 6: e21893. PMID 21755007 DOI: 10.1371/Journal.Pone.0021893  0.359
2011 Bosiljcic M, Hamilton MJ, Banath JP, Lepard NE, McDougal DC, Jia JX, Krystal G, Bennewith KL. Myeloid suppressor cells regulate the lung environment--letter. Cancer Research. 71: 5050-1; author reply. PMID 21750177 DOI: 10.1158/0008-5472.Can-10-3982  0.378
2011 Büchse T, Horras N, Lenfert E, Krystal G, Körbel S, Schümann M, Krause E, Mikkat S, Tiedge M. CIN85 interacting proteins in B cells-specific role for SHIP-1. Molecular & Cellular Proteomics : McP. 10: M110.006239. PMID 21725061 DOI: 10.1074/Mcp.M110.006239  0.469
2011 Cekic C, Casella CR, Sag D, Antignano F, Kolb J, Suttles J, Hughes MR, Krystal G, Mitchell TC. MyD88-dependent SHIP1 regulates proinflammatory signaling pathways in dendritic cells after monophosphoryl lipid A stimulation of TLR4. Journal of Immunology (Baltimore, Md. : 1950). 186: 3858-65. PMID 21339365 DOI: 10.4049/Jimmunol.1001034  0.426
2011 Hochdörfer T, Kuhny M, Zorn CN, Hendriks RW, Vanhaesebroeck B, Bohnacker T, Krystal G, Huber M. Activation of the PI3K pathway increases TLR-induced TNF-α and IL-6 but reduces IL-1β production in mast cells. Cellular Signalling. 23: 866-75. PMID 21262348 DOI: 10.1016/J.Cellsig.2011.01.012  0.37
2011 Kuroda E, Antignano F, Ho VW, Hughes MR, Ruschmann J, Lam V, Kawakami T, Kerr WG, McNagny KM, Sly LM, Krystal G. SHIP represses Th2 skewing by inhibiting IL-4 production from basophils. Journal of Immunology (Baltimore, Md. : 1950). 186: 323-32. PMID 21131429 DOI: 10.4049/Jimmunol.1002778  0.391
2011 Hamilton MJ, Ho VW, Kuroda E, Ruschmann J, Antignano F, Lam V, Krystal G. Role of SHIP in cancer. Experimental Hematology. 39: 2-13. PMID 21056081 DOI: 10.1016/J.Exphem.2010.11.002  0.443
2010 Hamilton MJ, Antignano F, von Rossum A, Boucher JL, Bennewith KL, Krystal G. TLR agonists that induce IFN-beta abrogate resident macrophage suppression of T cells. Journal of Immunology (Baltimore, Md. : 1950). 185: 4545-53. PMID 20844190 DOI: 10.4049/Jimmunol.1002045  0.374
2010 Antignano F, Ibaraki M, Ruschmann J, Jagdeo J, Krystal G. SHIP negatively regulates Flt3L-derived dendritic cell generation and positively regulates MyD88-independent TLR-induced maturation. Journal of Leukocyte Biology. 88: 925-35. PMID 20720161 DOI: 10.1189/Jlb.1209825  0.357
2010 Ruschmann J, Ho V, Antignano F, Kuroda E, Lam V, Ibaraki M, Snyder K, Kim C, Flavell RA, Kawakami T, Sly L, Turhan AG, Krystal G. Tyrosine phosphorylation of SHIP promotes its proteasomal degradation. Experimental Hematology. 38: 392-402, 402.e1. PMID 20304029 DOI: 10.1016/J.Exphem.2010.03.010  0.489
2010 Antignano F, Ibaraki M, Kim C, Ruschmann J, Zhang A, Helgason CD, Krystal G. SHIP is required for dendritic cell maturation. Journal of Immunology (Baltimore, Md. : 1950). 184: 2805-13. PMID 20154203 DOI: 10.4049/Jimmunol.0903170  0.376
2010 Gabhann JN, Higgs R, Brennan K, Thomas W, Damen JE, Ben Larbi N, Krystal G, Jefferies CA. Absence of SHIP-1 results in constitutive phosphorylation of tank-binding kinase 1 and enhanced TLR3-dependent IFN-beta production. Journal of Immunology (Baltimore, Md. : 1950). 184: 2314-20. PMID 20100929 DOI: 10.4049/Jimmunol.0902589  0.398
2010 Rauh MJ, Mahendru D, Shapiro R, Chesney A, Good D, Reis MD, Lam A, Krystal G, Buckstein R, Wells RA. Arginase and YKL-40, Effectors of Immunosuppressive Myeloid Cells, Are Over-Expressed In the Bone Marrow of Most Chronic Myelomonocytic Leukemia Patients, and Are Potential Prognostic Biomarkers In Myelodysplastic Syndrome Blood. 116: 1855-1855. DOI: 10.1182/Blood.V116.21.1855.1855  0.381
2009 Kuroda E, Ho V, Ruschmann J, Antignano F, Hamilton M, Rauh MJ, Antov A, Flavell RA, Sly LM, Krystal G. SHIP represses the generation of IL-3-induced M2 macrophages by inhibiting IL-4 production from basophils. Journal of Immunology (Baltimore, Md. : 1950). 183: 3652-60. PMID 19710468 DOI: 10.4049/Jimmunol.0900864  0.339
2009 Kennah M, Yau TY, Nodwell M, Krystal G, Andersen RJ, Ong CJ, Mui AL. Activation of SHIP via a small molecule agonist kills multiple myeloma cells. Experimental Hematology. 37: 1274-83. PMID 19703514 DOI: 10.1016/J.Exphem.2009.08.001  0.427
2009 Heuser M, Sly LM, Argiropoulos B, Kuchenbauer F, Lai C, Weng A, Leung M, Lin G, Brookes C, Fung S, Valk PJ, Delwel R, Löwenberg B, Krystal G, Humphries RK. Modeling the functional heterogeneity of leukemia stem cells: role of STAT5 in leukemia stem cell self-renewal. Blood. 114: 3983-93. PMID 19667399 DOI: 10.1182/Blood-2009-06-227603  0.376
2009 Haddon DJ, Antignano F, Hughes MR, Blanchet MR, Zbytnuik L, Krystal G, McNagny KM. SHIP1 is a repressor of mast cell hyperplasia, cytokine production, and allergic inflammation in vivo. Journal of Immunology (Baltimore, Md. : 1950). 183: 228-36. PMID 19542434 DOI: 10.4049/Jimmunol.0900427  0.442
2009 Locke NR, Patterson SJ, Hamilton MJ, Sly LM, Krystal G, Levings MK. SHIP regulates the reciprocal development of T regulatory and Th17 cells Journal of Immunology. 183: 975-983. PMID 19542365 DOI: 10.4049/Jimmunol.0803749  0.403
2009 Fehrenbach K, Lessmann E, Zorn CN, Kuhny M, Grochowy G, Krystal G, Leitges M, Huber M. Steel factor enhances supraoptimal antigen-induced IL-6 production from mast cells via activation of protein kinase C-beta. Journal of Immunology (Baltimore, Md. : 1950). 182: 7897-905. PMID 19494314 DOI: 10.4049/Jimmunol.0801773  0.452
2009 Sly LM, Hamilton MJ, Kuroda E, Ho VW, Antignano FL, Omeis SL, van Netten-Thomas CJ, Wong D, Brugger HK, Williams O, Feldman ME, Houseman BT, Fiedler D, Shokat KM, Krystal G. SHIP prevents lipopolysaccharide from triggering an antiviral response in mice. Blood. 113: 2945-54. PMID 19139077 DOI: 10.1182/Blood-2008-06-166082  0.381
2008 Sly LM, Kalesnikoff J, Lam V, Wong D, Song C, Omeis S, Chan K, Lee CW, Siraganian RP, Rivera J, Krystal G. IgE-induced mast cell survival requires the prolonged generation of reactive oxygen species. Journal of Immunology (Baltimore, Md. : 1950). 181: 3850-60. PMID 18768839 DOI: 10.4049/Jimmunol.181.6.3850  0.727
2008 Bishop JL, Sly LM, Krystal G, Finlay BB. The inositol phosphatase SHIP controls Salmonella enterica serovar Typhimurium infection in vivo. Infection and Immunity. 76: 2913-22. PMID 18426884 DOI: 10.1128/Iai.01596-07  0.352
2008 Argiropoulos B, Palmqvist L, Yung E, Kuchenbauer F, Heuser M, Sly LM, Wan A, Krystal G, Humphries RK. Linkage of Meis1 leukemogenic activity to multiple downstream effectors including Trib2 and Ccl3. Experimental Hematology. 36: 845-59. PMID 18375036 DOI: 10.1016/J.Exphem.2008.02.011  0.396
2008 Liu J, Wang L, Harvey-White J, Huang BX, Kim HY, Luquet S, Palmiter RD, Krystal G, Rai R, Mahadevan A, Razdan RK, Kunos G. Multiple pathways involved in the biosynthesis of anandamide. Neuropharmacology. 54: 1-7. PMID 17631919 DOI: 10.1016/J.Neuropharm.2007.05.020  0.382
2008 Heuser M, Sly L, Lai C, Leung M, Lin G, Argiropoulos B, Kuchenbauer F, Fung S, Brookes C, Krystal G, Humphries RK. Heterogeneity of Acute Myeloid Leukemia at the Stem Cell Level. Blood. 112: 1355-1355. DOI: 10.1182/Blood.V112.11.1355.1355  0.415
2007 Ong CJ, Ming-Lum A, Nodwell M, Ghanipour A, Yang L, Williams DE, Kim J, Demirjian L, Qasimi P, Ruschmann J, Cao LP, Ma K, Chung SW, Duronio V, Andersen RJ, ... Krystal G, et al. Small-molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells. Blood. 110: 1942-9. PMID 17502453 DOI: 10.1182/Blood-2007-03-079699  0.45
2007 Sly LM, Ho V, Antignano F, Ruschmann J, Hamilton M, Lam V, Rauh MJ, Krystal G. The role of SHIP in macrophages. Frontiers in Bioscience : a Journal and Virtual Library. 12: 2836-48. PMID 17485263  0.328
2007 Lee JS, Nauseef WM, Moeenrezakhanlou A, Sly LM, Noubir S, Leidal KG, Schlomann JM, Krystal G, Reiner NE. Monocyte p110alpha phosphatidylinositol 3-kinase regulates phagocytosis, the phagocyte oxidase, and cytokine production. Journal of Leukocyte Biology. 81: 1548-61. PMID 17369495 DOI: 10.1189/Jlb.0906564  0.41
2007 Park-Min KH, Serbina NV, Yang W, Ma X, Krystal G, Neel BG, Nutt SL, Hu X, Ivashkiv LB. FcγRIII-Dependent Inhibition of Interferon-γ Responses Mediates Suppressive Effects of Intravenous Immune Globulin Immunity. 26: 67-78. PMID 17239631 DOI: 10.1016/J.Immuni.2006.11.010  0.328
2007 Fehrenbach K, Port F, Grochowy G, Kalis C, Bessler W, Galanos C, Krystal G, Freudenberg M, Huber M. Stimulation of mast cells via FcvarepsilonR1 and TLR2: the type of ligand determines the outcome. Molecular Immunology. 44: 2087-94. PMID 17095089 DOI: 10.1016/J.Molimm.2006.09.011  0.406
2006 Zhou P, Kitaura H, Teitelbaum SL, Krystal G, Ross FP, Takeshita S. SHIP1 negatively regulates proliferation of osteoclast precursors via Akt-dependent alterations in D-type cyclins and p27. Journal of Immunology (Baltimore, Md. : 1950). 177: 8777-84. PMID 17142780 DOI: 10.4049/Jimmunol.177.12.8777  0.468
2006 Lessmann E, Grochowy G, Weingarten L, Giesemann T, Aktories K, Leitges M, Krystal G, Huber M. Insulin and insulin-like growth factor-1 promote mast cell survival via activation of the phosphatidylinositol-3-kinase pathway. Experimental Hematology. 34: 1532-41. PMID 17046573 DOI: 10.1016/J.Exphem.2006.05.022  0.34
2006 Palmqvist L, Argiropoulos B, Pineault N, Abramovich C, Sly LM, Krystal G, Wan A, Humphries RK. The Flt3 receptor tyrosine kinase collaborates with NUP98-HOX fusions in acute myeloid leukemia. Blood. 108: 1030-6. PMID 16861351 DOI: 10.1182/Blood-2005-12-007005  0.406
2005 Rauh MJ, Ho V, Pereira C, Sham A, Sly LM, Lam V, Huxham L, Minchinton AI, Mui A, Krystal G. SHIP represses the generation of alternatively activated macrophages. Immunity. 23: 361-74. PMID 16226502 DOI: 10.1016/J.Immuni.2005.09.003  0.358
2005 Gimborn K, Lessmann E, Kuppig S, Krystal G, Huber M. SHIP down-regulates FcepsilonR1-induced degranulation at supraoptimal IgE or antigen levels. Journal of Immunology (Baltimore, Md. : 1950). 174: 507-16. PMID 15611277 DOI: 10.4049/Jimmunol.174.1.507  0.421
2005 Rauh MJ, Sly LM, Kalesnikoff J, Hughes MR, Cao LP, Lam V, Krystal G. The role of SHIP1 in macrophage programming and activation. Biochemical Society Transactions. 32: 785-8. PMID 15494015 DOI: 10.1042/Bst0320785  0.46
2004 Sly LM, Rauh MJ, Kalesnikoff J, Song CH, Krystal G. LPS-induced upregulation of SHIP is essential for endotoxin tolerance. Immunity. 21: 227-39. PMID 15308103 DOI: 10.1016/J.Immuni.2004.07.010  0.697
2004 Hernandez-Hansen V, Smith AJ, Surviladze Z, Chigaev A, Mazel T, Kalesnikoff J, Lowell CA, Krystal G, Sklar LA, Wilson BS, Oliver JM. Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells. Journal of Immunology (Baltimore, Md. : 1950). 173: 100-12. PMID 15210764 DOI: 10.4049/Jimmunol.173.1.100  0.754
2004 Lahlil R, Martin R, Aplan PD, Begley CG, Damen JE, Krystal G, Hoang T. The SCL Transcription Factor Supports Erythroid Cell Survival and Differentiation Downstream of the Erythropoietin Receptor. Blood. 104: 818-818. DOI: 10.1182/Blood.V104.11.818.818  0.426
2004 Rauh MJ, Ho V, Huxham L, Sly L, Minchinton AI, Krystal G. Ship Represses the PI3-Kinase-Mediated Skewing of Myeloid Cell Development towards Alternative (M-2) Macrophages. Blood. 104: 777-777. DOI: 10.1182/Blood.V104.11.777.777  0.359
2004 Sly LM, Omeis SL, Rauh MJ, Krystal G. Ship Is Essential for Both Endotoxin- and CpG-Induced Tolerance and for Their Cross-Tolerance. Blood. 104: 3440-3440. DOI: 10.1182/Blood.V104.11.3440.3440  0.395
2004 Krystal G. IgE-induced signaling: only the weak survive Blood. 103: 2868-2869. DOI: 10.1182/Blood-2004-02-0479  0.364
2003 Sly LM, Rauh MJ, Kalesnikoff J, Büchse T, Krystal G. SHIP, SHIP2, and PTEN activities are regulated in vivo by modulation of their protein levels: SHIP is up-regulated in macrophages and mast cells by lipopolysaccharide. Experimental Hematology. 31: 1170-81. PMID 14662322 DOI: 10.1016/J.Exphem.2003.09.011  0.756
2003 Baran CP, Tridandapani S, Helgason CD, Humphries RK, Krystal G, Marsh CB. The inositol 5'-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activity. The Journal of Biological Chemistry. 278: 38628-36. PMID 12882960 DOI: 10.1074/Jbc.M305021200  0.346
2003 Jiang X, Stuible M, Chalandon Y, Li A, Chan WY, Eisterer W, Krystal G, Eaves A, Eaves C. Evidence for a positive role of SHIP in the BCR-ABL-mediated transformation of primitive murine hematopoietic cells and in human chronic myeloid leukemia. Blood. 102: 2976-84. PMID 12829595 DOI: 10.1182/Blood-2003-05-1550  0.402
2003 Lam V, Kalesnikoff J, Lee CW, Hernandez-Hansen V, Wilson BS, Oliver JM, Krystal G. IgE alone stimulates mast cell adhesion to fibronectin via pathways similar to those used by IgE + antigen but distinct from those used by Steel factor. Blood. 102: 1405-13. PMID 12702510 DOI: 10.1182/Blood-2002-10-3176  0.756
2003 Kalesnikoff J, Sly LM, Hughes MR, Büchse T, Rauh MJ, Cao LP, Lam V, Mui A, Huber M, Krystal G. The role of SHIP in cytokine-induced signaling Reviews of Physiology, Biochemistry and Pharmacology. 149: 87-103. PMID 12692707 DOI: 10.1007/S10254-003-0016-Y  0.451
2003 Rauh MJ, Kalesnikoff J, Hughes M, Sly L, Lam V, Krystal G. Role of Src homology 2-containing-inositol 5'-phosphatase (SHIP) in mast cells and macrophages. Biochemical Society Transactions. 31: 286-91. PMID 12546703 DOI: 10.1042/Bst0310286  0.487
2002 Kalesnikoff J, Lam V, Krystal G. SHIP represses mast cell activation and reveals that IgE alone triggers signaling pathways which enhance normal mast cell survival Molecular Immunology. 38: 1201-1206. PMID 12217384 DOI: 10.1016/S0161-5890(02)00064-0  0.754
2002 Takeshita S, Namba N, Zhao JJ, Jiang Y, Genant HK, Silva MJ, Brodt MD, Helgason CD, Kalesnikoff J, Rauh MJ, Humphries RK, Krystal G, Teitelbaum SL, Ross FP. SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts. Nature Medicine. 8: 943-9. PMID 12161749 DOI: 10.1038/Nm752  0.727
2002 Leitges M, Gimborn K, Elis W, Kalesnikoff J, Hughes MR, Krystal G, Huber M. Protein kinase C-delta is a negative regulator of antigen-induced mast cell degranulation. Molecular and Cellular Biology. 22: 3970-80. PMID 12024011 DOI: 10.1128/Mcb.22.12.3970-3980.2002  0.761
2002 Huber M, Kalesnikoff J, Reth M, Krystal G. The role of SHIP in mast cell degranulation and IgE-induced mast cell survival. Immunology Letters. 82: 17-21. PMID 12008029 DOI: 10.1016/S0165-2478(02)00012-3  0.761
2002 Kalesnikoff J, Baur N, Leitges M, Hughes MR, Damen JE, Huber M, Krystal G. SHIP negatively regulates IgE + antigen-induced IL-6 production in mast cells by inhibiting NF-kappa B activity. Journal of Immunology (Baltimore, Md. : 1950). 168: 4737-46. PMID 11971024 DOI: 10.4049/Jimmunol.168.9.4737  0.741
2002 Scheid MP, Huber M, Damen JE, Hughes M, Kang V, Neilsen P, Prestwich GD, Krystal G, Duronio V. Phosphatidylinositol (3,4,5)P3 is essential but not sufficient for protein kinase B (PKB) activation; phosphatidylinositol (3,4)P2 is required for PKB phosphorylation at Ser-473: studies using cells from SH2-containing inositol-5-phosphatase knockout mice. The Journal of Biological Chemistry. 277: 9027-35. PMID 11781306 DOI: 10.1074/Jbc.M106755200  0.499
2001 Kalesnikoff J, Huber M, Lam V, Damen JE, Zhang J, Siraganian RP, Krystal G. Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival. Immunity. 14: 801-11. PMID 11420049 DOI: 10.1016/S1074-7613(01)00159-5  0.749
2001 Malbec O, Schmitt C, Bruhns P, Krystal G, Fridman WH, Daëron M. Src homology 2 domain-containing inositol 5-phosphatase 1 mediates cell cycle arrest by FcgammaRIIB. The Journal of Biological Chemistry. 276: 30381-91. PMID 11359765 DOI: 10.1074/JBC.M011094200  0.409
2001 Damen JE, Ware MD, Kalesnikoff J, Hughes MR, Krystal G. SHIP's C-terminus is essential for its hydrolysis of PIP3 and inhibition of mast cell degranulation. Blood. 97: 1343-51. PMID 11222379 DOI: 10.1182/Blood.V97.5.1343  0.807
2001 Krystal G. Another SHIP on the horizon Blood. 98: 2000-2000. DOI: 10.1182/Blood.V98.7.2000A  0.397
2000 Krystal G. Lipid phosphatases in the immune system. Seminars in Immunology. 12: 397-403. PMID 10995586 DOI: 10.1006/Smim.2000.0222  0.418
2000 Huber M, Hughes MR, Krystal G. Thapsigargin-induced degranulation of mast cells is dependent on transient activation of phosphatidylinositol-3 kinase. Journal of Immunology (Baltimore, Md. : 1950). 165: 124-33. PMID 10861044 DOI: 10.4049/Jimmunol.165.1.124  0.502
2000 Pasquet JM, Quek L, Stevens C, Bobe R, Huber M, Duronio V, Krystal G, Watson SP. Phosphatidylinositol 3,4,5-trisphosphate regulates Ca2+ entry via Btk in platelets and megakaryocytes without increasing phospholipase C activity Embo Journal. 19: 2793-2802. PMID 10856225 DOI: 10.1093/Emboj/19.12.2793  0.371
2000 Helgason CD, Kalberer CP, Damen JE, Chappel SM, Pineault N, Krystal G, Humphries RK. A dual role for Src homology 2 domain-containing inositol-5-phosphatase (SHIP) in immunity: aberrant development and enhanced function of b lymphocytes in ship -/- mice. Journal of Experimental Medicine. 191: 781-794. PMID 10704460 DOI: 10.1084/Jem.191.5.781  0.433
2000 Kim CH, Hangoc G, Cooper S, Helgason CD, Yew S, Humphries RK, Krystal G, Broxmeyer HE. Altered responsiveness to chemokines due to targeted disruption of SHIP. The Journal of Clinical Investigation. 104: 1751-9. PMID 10606629 DOI: 10.1172/Jci7310  0.472
2000 Rabkin SW, Huber M, Krystal G. Modulation of palmitate-induced cardiomyocyte cell death by interventions that alter intracellular calcium. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 61: 195-201. PMID 10582660 DOI: 10.1054/Plef.1999.0090  0.326
2000 Damen J, Ware M, Kalesnikoff J, Krystal G. The proline-rich c-terminus of ship is required for its inhibition of mast cell degranulation Experimental Hematology. 28: 84-85. DOI: 10.1016/S0301-472X(00)00351-9  0.796
1999 Krystal G, Damen JE, Helgason CD, Huber M, Hughes MR, Kalesnikoff J, Lam V, Rosten P, Ware MD, Yew S, Humphries RK. SHIPs ahoy. The International Journal of Biochemistry & Cell Biology. 31: 1007-10. PMID 10582334  0.733
1999 Wickrema A, Uddin S, Sharma A, Chen F, Alsayed Y, Ahmad S, Sawyer ST, Krystal G, Yi T, Nishada K, Hibi M, Hirano T, Platanias LC. Engagement of Gab1 and Gab2 in erythropoietin signaling. The Journal of Biological Chemistry. 274: 24469-74. PMID 10455108 DOI: 10.1074/Jbc.274.35.24469  0.444
1999 Huber M, Helgason CD, Damen JE, Scheid M, Duronio V, Liu L, Ware MD, Humphries RK, Krystal G. The role of SHIP in growth factor induced signalling. Progress in Biophysics and Molecular Biology. 71: 423-34. PMID 10354708 DOI: 10.1016/S0079-6107(98)00049-2  0.753
1999 Huber M, Helgason CD, Scheid MP, Duronio V, Humphries RK, Krystal G. Targeted disruption of SHIP leads to Steel factor-induced degranulation of mast cells. The Embo Journal. 17: 7311-9. PMID 9857188 DOI: 10.1093/Emboj/17.24.7311  0.445
1999 Huber M, Helgason CD, Damen JE, Scheid MP, Duronio V, Lam V, Humphries RK, Krystal G. The Role of the SRC Homology 2-Containing Inositol 5′-Phosphatase in FcɛR1-Induced Signaling Current Topics in Microbiology and Immunology. 244: 29-41. DOI: 10.1007/978-3-642-58537-1_3  0.319
1998 Huber M, Helgason CD, Damen JE, Liu L, Humphries RK, Krystal G. The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation. Proceedings of the National Academy of Sciences of the United States of America. 95: 11330-5. PMID 9736736 DOI: 10.1073/Pnas.95.19.11330  0.492
1998 Damen JE, Liu L, Ware MD, Ermolaeva M, Majerus PW, Krystal G. Multiple forms of the SH2-containing inositol phosphatase, SHIP, are generated by C-terminal truncation. Blood. 92: 1199-205. PMID 9694708  0.683
1998 Helgason CD, Damen JE, Rosten P, Grewal R, Sorensen P, Chappel SM, Borowski A, Jirik F, Krystal G, Humphries RK. Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span Genes and Development. 12: 1610-1620. PMID 9620849  0.369
1998 Le Dréan E, Vély F, Olcese L, Cambiaggi A, Guia S, Krystal G, Gervois N, Moretta A, Jotereau F, Vivier E. Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: association of NKG2A with SHP-1 and SHP-2 protein-tyrosine phosphatases. European Journal of Immunology. 28: 264-76. PMID 9485206 DOI: 10.1002/(Sici)1521-4141(199801)28:01<264::Aid-Immu264>3.0.Co;2-O  0.404
1998 Maguer-Satta V, Burl S, Liu L, Damen J, Chahine H, Krystal G, Eaves A, Eaves C. BCR-ABL accelerates C2-ceramide-induced apoptosis. Oncogene. 16: 237-48. PMID 9464542 DOI: 10.1038/Sj.Onc.1201533  0.431
1998 Damen JE, Liu L, Ware MD, Ermolaeva M, Majerus PW, Krystal G. Multiple Forms of the SH2-Containing Inositol Phosphatase, SHIP, Are Generated by C-Terminal Truncation Blood. 92: 1199-1205. DOI: 10.1182/Blood.V92.4.1199  0.702
1998 Damen JE, Krosl J, Morrison D, Pelech S, Krystal G. The Hyperresponsiveness of Cells Expressing Truncated Erythropoietin Receptors Is Contingent on Insulin-Like Growth Factor-1 in Fetal Calf Serum Blood. 92: 425-433. DOI: 10.1182/Blood.V92.2.425.414K08_425_433  0.391
1997 Wang S, Vrana JA, Bartimole TM, Freemerman AJ, Jarvis WD, Kramer LB, Krystal G, Dent P, Grant S. Agents that down-regulate or inhibit protein kinase C circumvent resistance to 1-beta-D-arabinofuranosylcytosine-induced apoptosis in human leukemia cells that overexpress Bcl-2. Molecular Pharmacology. 52: 1000-9. PMID 9396780 DOI: 10.1124/Mol.52.6.1000  0.309
1997 Vély F, Olivero S, Olcese L, Moretta A, Damen JE, Liu L, Krystal G, Cambier JC, Daëron M, Vivier E. Differential association of phosphatases with hematopoietic co-receptors bearing immunoreceptor tyrosine-based inhibition motifs. European Journal of Immunology. 27: 1994-2000. PMID 9295037 DOI: 10.1002/Eji.1830270825  0.417
1997 Wakao H, Chida D, Damen JE, Krystal G, Miyajima A. A possible involvement of Stat5 in erythropoietin-induced hemoglobin synthesis. Biochemical and Biophysical Research Communications. 234: 198-205. PMID 9168989 DOI: 10.1006/Bbrc.1997.6486  0.448
1997 Liu L, Damen JE, Ware MD, Krystal G. Interleukin-3 induces the association of the inositol 5-phosphatase SHIP with SHP2. The Journal of Biological Chemistry. 272: 10998-1001. PMID 9110989 DOI: 10.1074/Jbc.272.17.10998  0.73
1997 Lamkin TD, Walk SF, Liu L, Damen JE, Krystal G, Ravichandran KS. Shc interaction with Src homology 2 domain containing inositol phosphatase (SHIP) in vivo requires the Shc-phosphotyrosine binding domain and two specific phosphotyrosines on SHIP. The Journal of Biological Chemistry. 272: 10396-401. PMID 9099679 DOI: 10.1074/Jbc.272.16.10396  0.441
1997 Liu L, Damen JE, Hughes MR, Babic I, Jirik FR, Krystal G. The Src homology 2 (SH2) domain of SH2-containing inositol phosphatase (SHIP) is essential for tyrosine phosphorylation of ship, its association with Shc, and its induction of apoptosis Journal of Biological Chemistry. 272: 8983-8988. PMID 9083021 DOI: 10.1074/Jbc.272.14.8983  0.482
1997 Liu L, Damen JE, Ware M, Hughes M, Krystal G. SHIP, a new player in cytokine-induced signalling. Leukemia. 11: 181-4. PMID 9009077 DOI: 10.1038/Sj.Leu.2400559  0.743
1997 Guilherme A, Klarlund JK, Krystal G, Czech MP. Regulation of phosphatidylinositol 3,4,5-trisphosphate 5'-phosphatase activity by insulin. The Journal of Biological Chemistry. 271: 29533-6. PMID 8939879 DOI: 10.1074/Jbc.271.47.29533  0.357
1996 Liu L, Jefferson AB, Zhang X, Norris FA, Majerus PW, Krystal G. A novel phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase associates with the interleukin-3 receptor. The Journal of Biological Chemistry. 271: 29729-33. PMID 8939907 DOI: 10.1074/Jbc.271.47.29729  0.398
1996 Rajotte D, Sadowski HB, Haman A, Gopalbhai K, Meloche S, Liu L, Krystal G, Hoang T. Contribution of both STAT and SRF/TCF to c-fos promoter activation by granulocyte-macrophage colony-stimulating factor. Blood. 88: 2906-16. PMID 8874187 DOI: 10.1182/Blood.V88.8.2906.Bloodjournal8882906  0.432
1996 Ware MD, Rosten P, Damen JE, Liu L, Humphries RK, Krystal G. Cloning and characterization of human SHIP, the 145-kD inositol 5-phosphatase that associates with SHC after cytokine stimulation. Blood. 88: 2833-40. PMID 8874179 DOI: 10.1182/Blood.V88.8.2833.Bloodjournal8882833  0.706
1996 Rabkin SW, Damen JE, Goutsouliak V, Krystal G. Cardiac hypertrophy in the Dahl rat is associated with increased tyrosine phosphorylation of several cytosolic proteins, including a 120 kDa protein. American Journal of Hypertension. 9: 230-6. PMID 8695021 DOI: 10.1016/0895-7061(95)00382-7  0.3
1996 Damen JE, Liu L, Rosten P, Humphries RK, Jefferson AB, Majerus PW, Krystal G. The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase. Proceedings of the National Academy of Sciences of the United States of America. 93: 1689-93. PMID 8643691 DOI: 10.1073/Pnas.93.4.1689  0.416
1996 Tauchi T, Damen J, Toyama K, Feng G, Broxmeyer H, Krystal G. Tyrosine 425 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation, and promotes mitogenesis Blood. 87: 4495-4501. DOI: 10.1182/Blood.V87.11.4495.Bloodjournal87114495  0.477
1995 Damen JE, Cutler RL, Jiao H, Yi T, Krystal G. Phosphorylation of tyrosine 503 in the erythropoietin receptor (EpR) is essential for binding the P85 subunit of phosphatidylinositol (PI) 3-kinase and for EpR-associated PI 3-kinase activity. The Journal of Biological Chemistry. 270: 23402-8. PMID 7559499 DOI: 10.1074/Jbc.270.40.23402  0.474
1995 Liu L, Cutler RL, Krystal G. Identification and characterization of an interleukin-3 receptor-associated 110-kDa serine/threonine kinase. The Journal of Biological Chemistry. 270: 22422-7. PMID 7545678 DOI: 10.1074/Jbc.270.38.22422  0.356
1995 Krosl J, Damen J, Krystal G, Humphries R. Erythropoietin and interleukin-3 induce distinct events in erythropoietin receptor-expressing BA/F3 cells Blood. 85: 50-56. DOI: 10.1182/Blood.V85.1.50.Bloodjournal85150  0.365
1995 Damen JE, Wakao H, Miyajima A, Krosl J, Humphries RK, Cutler RL, Krystal G. Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation. The Embo Journal. 14: 5557-5568. DOI: 10.1002/J.1460-2075.1995.Tb00243.X  0.463
1994 Liu L, Damen JE, Cutler RL, Krystal G. Multiple cytokines stimulate the binding of a common 145-kilodalton protein to Shc at the Grb2 recognition site of Shc. Molecular and Cellular Biology. 14: 6926-35. PMID 7523859 DOI: 10.1128/Mcb.14.10.6926  0.459
1993 Yi T, Mui ALF, Krystal G, Ihle JN. Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor β chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis Molecular and Cellular Biology. 13: 7577-7586. PMID 8246974 DOI: 10.1128/Mcb.13.12.7577  0.42
1993 See RH, Krystal G, Chow AW. Receptors for toxic shock syndrome toxin-1 and staphylococcal enterotoxin A on human blood monocytes. Canadian Journal of Microbiology. 38: 937-44. PMID 1281444 DOI: 10.1139/M92-151  0.306
1993 Damen J, Liu L, Cutler R, Krystal G. Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein Blood. 82: 2296-2303. DOI: 10.1182/Blood.V82.8.2296.2296  0.471
1993 Damen J, Mui A, Puil L, Pawson T, Krystal G. Phosphatidylinositol 3-kinase associates, via its Src homology 2 domains, with the activated erythropoietin receptor Blood. 81: 3204-3210. DOI: 10.1182/Blood.V81.12.3204.3204  0.455
1992 Mui ALF, Kay RJ, Humphries RK, Krystal G. Ligand-induced phosphorylation of the murine interleukin 3 receptor signals its cleavage Proceedings of the National Academy of Sciences of the United States of America. 89: 10812-10816. PMID 1332057 DOI: 10.1073/Pnas.89.22.10812  0.434
1992 Damen J, Mui A, Hughes P, Humphries K, Krystal G. Erythropoietin-induced tyrosine phosphorylations in a high erythropoietin receptor-expressing lymphoid cell line Blood. 80: 1923-1932. DOI: 10.1182/Blood.V80.8.1923.1923  0.475
1992 Wognum A, Krystal G, Eaves C, Eaves A, Lansdorp P. Increased erythropoietin-receptor expression on CD34-positive bone marrow cells from patients with chronic myeloid leukemia Blood. 79: 642-649. DOI: 10.1182/Blood.V79.3.642.642  0.332
1990 See RH, Krystal G, Chow AW. Binding competition of toxic shock syndrome toxin 1 and other staphylococcal exoproteins for receptors on human peripheral blood mononuclear cells. Infection and Immunity. 58: 2392-6. PMID 1694828 DOI: 10.1128/Iai.58.7.2392-2396.1990  0.317
1990 Wognum A, Lansdorp P, Humphries R, Krystal G. Detection and isolation of the erythropoietin receptor using biotinylated erythropoietin Blood. 76: 697-705. DOI: 10.1182/Blood.V76.4.697.Bloodjournal764697  0.367
1989 Murthy S, Sorensen P, Mui A, Krystal G. Interleukin-3 down-regulates its own receptor Blood. 73: 1180-1187. DOI: 10.1182/Blood.V73.5.1180.1180  0.391
1989 Sorensen P, Mui A, Murthy S, Krystal G. Interleukin-3, GM-CSF, and TPA induce distinct phosphorylation events in an interleukin 3-dependent multipotential cell line Blood. 73: 406-418. DOI: 10.1182/Blood.V73.2.406.Bloodjournal732406  0.469
1988 Wognum A, Lansdorp P, Eaves C, Krystal G. Use of a sensitive bioimmunoabsorbent assay to isolate and characterize monoclonal antibodies to biologically active human erythropoietin Blood. 71: 1731-1737. DOI: 10.1182/Blood.V71.6.1731.Bloodjournal7161731  0.308
1987 Mitjavila M, Villeval J, Cramer P, Henri A, Gasson J, Krystal G, Tulliez M, Berger R, Breton-Gorius J, Vainchenker W. Effects of granulocyte-macrophage colony-stimulating factor and erythropoietin on leukemic erythroid colony formation in human early erythroblastic leukemias Blood. 70: 965-973. DOI: 10.1182/Blood.V70.4.965.Bloodjournal704965  0.33
1984 Krystal G, Eaves CJ, Eaves AC. CM Affi-Gel Blue chromatography of human urine: a simple one-step procedure for obtaining erythropoietin suitable for in vitro erythropoietic progenitor assays. British Journal of Haematology. 58: 533-46. PMID 6498104 DOI: 10.1111/J.1365-2141.1984.Tb04001.X  0.311
1981 Goldie JH, Krystal G, Hartley D, Gudauskas G, Dedhar S. A methotrexate insensitive variant of folate reductase present in two lines of methotrexate-resistant L5178Y cells. European Journal of Cancer. 16: 1539-46. PMID 7227429 DOI: 10.1016/0014-2964(80)90026-2  0.316
1978 Krystal G, Rattner JB, Hamkalo BA. Partial purification and characterization of the intercellular bridge from cultured mouse cells. Proceedings of the National Academy of Sciences of the United States of America. 75: 4977-81. PMID 283407 DOI: 10.1073/Pnas.75.10.4977  0.328
1975 Krystal G, Winn P, Millward S, Sakuma S. Evidence for phosphoproteins in reovirus. Virology. 64: 505-12. PMID 1169848 DOI: 10.1016/0042-6822(75)90127-0  0.308
1973 Krystal G, Scholefield PG. The partial purification and properties of uridine kinase from Ehrlich ascites tumor cells. Canadian Journal of Biochemistry. 51: 379-89. PMID 4696063 DOI: 10.1139/O73-044  0.321
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