Bryan Maloney - Publications

Affiliations: 
Psychiatry Indiana University School of Medicine, Indianapolis, IN, United States 
Area:
Alzheimer's Autism Neuroscience

69 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Lahiri DK, Maloney B, Wang R, White FA, Sambamurti K, Greig NH, Counts SE. The seeds of its regulation: natural antisense transcripts as single-gene control switches in neurodegenerative disorders. Ageing Research Reviews. 102336. PMID 38740308 DOI: 10.1016/j.arr.2024.102336  0.321
2023 Schmued L, Maloney B, Schmued C, Lahiri DK. Treatment with 1, 10 Phenanthroline-5-Amine Reduced Amyloid Burden in a Mouse Model of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 38073385 DOI: 10.3233/JAD-221285  0.342
2022 Wang R, Chopra N, Nho K, Maloney B, Obukhov AG, Nelson PT, Counts SE, Lahiri DK. Human microRNA (miR-20b-5p) modulates Alzheimer's disease pathways and neuronal function, and a specific polymorphism close to the MIR20B gene influences Alzheimer's biomarkers. Molecular Psychiatry. PMID 35087196 DOI: 10.1038/s41380-021-01351-3  0.317
2020 Westmark CJ, Maloney B, Alisch RS, Sokol DK, Lahiri DK. FMRP Regulates the Nuclear Export of Adam9 and Psen1 mRNAs: Secondary Analysis of an N-Methyladenosine Dataset. Scientific Reports. 10: 10781. PMID 32612155 DOI: 10.1038/S41598-020-66394-Y  0.37
2020 Ray B, Maloney B, Sambamurti K, Karnati HK, Nelson PT, Greig NH, Lahiri DK. Correction: Rivastigmine modifies the α-secretase pathway and potentially early Alzheimer's disease. Translational Psychiatry. 10: 81. PMID 32123156 DOI: 10.1038/S41398-020-0757-2  0.373
2020 Ray B, Maloney B, Sambamurti K, Karnati HK, Nelson PT, Greig NH, Lahiri DK. Rivastigmine modifies the α-secretase pathway and potentially early Alzheimer's disease. Translational Psychiatry. 10: 47. PMID 32066688 DOI: 10.1038/S41398-020-0709-X  0.445
2020 Chopra N, Wang R, Maloney B, Nho K, Beck JS, Pourshafie N, Niculescu A, Saykin AJ, Rinaldi C, Counts SE, Lahiri DK. MicroRNA-298 reduces levels of human amyloid-β precursor protein (APP), β-site APP-converting enzyme 1 (BACE1) and specific tau protein moieties. Molecular Psychiatry. PMID 31942037 DOI: 10.1038/S41380-019-0610-2  0.429
2019 Maloney B, Balaraman Y, Liu Y, Chopra N, Edenberg HJ, Kelsoe J, Nurnberger JI, Lahiri DK. Lithium alters expression of RNAs in a type-specific manner in differentiated human neuroblastoma neuronal cultures, including specific genes involved in Alzheimer's disease. Scientific Reports. 9: 18261. PMID 31797941 DOI: 10.1016/J.Biopsych.2020.02.779  0.327
2019 Sokol DK, Maloney B, Westmark CJ, Lahiri DK. Novel Contribution of Secreted Amyloid-β Precursor Protein to White Matter Brain Enlargement in Autism Spectrum Disorder. Frontiers in Psychiatry. 10: 165. PMID 31024350 DOI: 10.3389/Fpsyt.2019.00165  0.399
2019 Wang R, Maloney B, Lahiri DK. P4-102: THE REPRESSOR ELEMENT 1-SILENCING TRANSCRIPTION FACTOR (REST) IN ALZHEIMER'S DISEASE Alzheimer's & Dementia. 15: P1314-P1314. DOI: 10.1016/J.Jalz.2019.06.3763  0.391
2019 Wang R, Chopra N, Maloney B, Lahiri DK. P3-150: DYSREGULATION OF THE Aβ DEGRADING ENZYME NEPRILYSIN (MME) COULD CONTRIBUTE TO ALZHEIMER'S DISEASE Alzheimer's & Dementia. 15: P989-P989. DOI: 10.1016/J.Jalz.2019.06.3178  0.417
2018 Long JM, Maloney B, Rogers JT, Lahiri DK. Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5'-untranslated region: Implications in Alzheimer's disease. Molecular Psychiatry. PMID 30470799 DOI: 10.1038/S41380-018-0266-3  0.377
2018 Konar A, Kumar A, Maloney B, Lahiri DK, Thakur MK. A serine protease KLK8 emerges as a regulator of regulators in memory: Microtubule protein dependent neuronal morphology and PKA-CREB signaling. Scientific Reports. 8: 9928. PMID 29967374 DOI: 10.1038/S41598-018-27640-6  0.307
2017 Lahiri DK, Maloney B, Greig NH. Are pulmonary fibrosis and Alzheimer's disease linked? Shared dysregulation of two miRNA species and downstream pathways accompany both disorders. The Journal of Biological Chemistry. 292: 20353. PMID 29222197 DOI: 10.1074/Jbc.L117.000502  0.318
2017 Bayon BL, Maloney B, Chopra N, White FA, Xu X, Ratan RR, Lahiri DK. [O4-06-01]: SP1-MODULATING COMPOUNDS AS A NOVEL DRUG TARGET FOR ALZHEIMER'S DISEASE (AD) Alzheimer's & Dementia. 13: P1241-P1241. DOI: 10.1016/J.Jalz.2017.07.448  0.376
2017 Lahiri DK, Maloney B, Ray B, Sokol DK. [P2-159]: DOES THE “BIOCHEMICAL INVERSION” OF ALZHEIMER's DISEASE AND AUTISM SPECTRUM DISORDER PROVIDE LATE-LIFE PROTECTION FROM AN EARLY-LIFE CONDITION? Alzheimer's & Dementia. 13: P668-P669. DOI: 10.1016/J.Jalz.2017.06.810  0.352
2016 Westmark CJ, Sokol DK, Maloney B, Lahiri DK. Novel roles of amyloid-beta precursor protein metabolites in fragile X syndrome and autism. Molecular Psychiatry. PMID 27573877 DOI: 10.1038/Mp.2016.134  0.46
2016 Maloney B, Lahiri DK. Epigenetics of dementia: understanding the disease as a transformation rather than a state. The Lancet. Neurology. 15: 760-74. PMID 27302240 DOI: 10.1016/S1474-4422(16)00065-X  0.369
2016 Ray B, Sokol DK, Maloney B, Lahiri DK. Finding novel distinctions between the sAPPα-mediated anabolic biochemical pathways in Autism Spectrum Disorder and Fragile X Syndrome plasma and brain tissue. Scientific Reports. 6: 26052. PMID 27212113 DOI: 10.1038/Srep26052  0.451
2016 Lahiri DK, Maloney B, Bayon BL, Chopra N, White FA, Greig NH, Nurnberger JI. Transgenerational latent early-life associated regulation unites environment and genetics across generations. Epigenomics. PMID 26950428 DOI: 10.2217/Epi.15.117  0.316
2016 Lahiri DK, Maloney B, Ray B, Sokol DK. P4-305: Novel Parallels and Distinctions Among App Metabolite Pathways in Alzheimer's Disease and Neurodevelopmental Disorders Alzheimer's & Dementia. 12: P1150-P1150. DOI: 10.1016/J.Jalz.2016.07.048  0.402
2015 Sokol D, Lahiri D, Maloney B, Ho C. B-71Enlarged Brain Volume and Elevated Secreted Amyloid Precursor Protein-Alpha (sAPP) Levels in Autism are Consistent with sAPP Mediated Anabolic Pathway and Macrocephaly Archives of Clinical Neuropsychology. 30: 548-549. DOI: 10.1093/Arclin/Acv047.166  0.321
2015 Lahiri DK, Maloney B, Long J, Chopra N, Bayon BL, Greig NH, Sambamurti K, Spence J, Ray B. P2-048: Does the mini-mental state examination (MMSE) measure a deeper biological process? modeling mmse score versus three selected mirna levels may reveal pathological roles in Alzheimer's disease progression Alzheimer's & Dementia. 11: P499-P500. DOI: 10.1016/J.Jalz.2015.06.584  0.325
2014 Erickson CA, Ray B, Maloney B, Wink LK, Bowers K, Schaefer TL, McDougle CJ, Sokol DK, Lahiri DK. Impact of acamprosate on plasma amyloid-β precursor protein in youth: a pilot analysis in fragile X syndrome-associated and idiopathic autism spectrum disorder suggests a pharmacodynamic protein marker. Journal of Psychiatric Research. 59: 220-8. PMID 25300441 DOI: 10.1016/J.Jpsychires.2014.07.011  0.33
2014 Lahiri DK, Maloney B, Long JM, Greig NH. Lessons from a BACE1 inhibitor trial: off-site but not off base. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: S411-9. PMID 24530026 DOI: 10.1016/J.Jalz.2013.11.004  0.41
2014 Perez FP, Bose D, Maloney B, Nho K, Shah K, Lahiri DK. Late-onset Alzheimer's disease, heating up and foxed by several proteins: pathomolecular effects of the aging process. Journal of Alzheimer's Disease : Jad. 40: 1-17. PMID 24326519 DOI: 10.3233/Jad-131544  0.375
2013 Lahiri DK, Sokol DK, Erickson C, Ray B, Ho CY, Maloney B. Autism as early neurodevelopmental disorder: evidence for an sAPPα-mediated anabolic pathway. Frontiers in Cellular Neuroscience. 7: 94. PMID 23801940 DOI: 10.3389/Fncel.2013.00094  0.414
2013 Lahiri DK, Maloney B, Rogers JT, Ge YW. PuF, an antimetastatic and developmental signaling protein, interacts with the Alzheimer's amyloid-β precursor protein via a tissue-specific proximal regulatory element (PRE). Bmc Genomics. 14: 68. PMID 23368879 DOI: 10.1186/1471-2164-14-68  0.522
2012 Lahiri DK, Maloney B. Gene × environment interaction by a longitudinal epigenome-wide association study (LEWAS) overcomes limitations of genome-wide association study (GWAS). Epigenomics. 4: 685-99. PMID 23244313 DOI: 10.2217/Epi.12.60  0.313
2012 Lahiri DK, Maloney B. The "LEARn" (latent early-life associated regulation) model: an epigenetic pathway linking metabolic and cognitive disorders. Journal of Alzheimer's Disease : Jad. 30: S15-30. PMID 22555376 DOI: 10.3233/Jad-2012-120373  0.373
2012 Maloney B, Lahiri DK. Structural and functional characterization of H2 haplotype MAPT promoter: unique neurospecific domains and a hypoxia-inducible element would enhance rationally targeted tauopathy research for Alzheimer's disease. Gene. 501: 63-78. PMID 22310385 DOI: 10.1016/J.Gene.2012.01.049  0.436
2012 Maloney B, Sambamurti K, Zawia N, Lahiri DK. Applying epigenetics to Alzheimer's disease via the latent early-life associated regulation (LEARn) model. Current Alzheimer Research. 9: 589-99. PMID 22300406 DOI: 10.2174/156720512800617955  0.481
2012 Bihaqi SW, Schumacher A, Maloney B, Lahiri DK, Zawia NH. Do epigenetic pathways initiate late onset Alzheimer disease (LOAD): towards a new paradigm. Current Alzheimer Research. 9: 574-88. PMID 22300405 DOI: 10.2174/156720512800617982  0.41
2011 Bailey JA, Maloney B, Ge YW, Lahiri DK. Functional activity of the novel Alzheimer's amyloid β-peptide interacting domain (AβID) in the APP and BACE1 promoter sequences and implications in activating apoptotic genes and in amyloidogenesis. Gene. 488: 13-22. PMID 21708232 DOI: 10.1016/J.Gene.2011.06.017  0.483
2011 Maloney B, Lahiri DK. The Alzheimer's amyloid β-peptide (Aβ) binds a specific DNA Aβ-interacting domain (AβID) in the APP, BACE1, and APOE promoters in a sequence-specific manner: characterizing a new regulatory motif. Gene. 488: 1-12. PMID 21699964 DOI: 10.1016/J.Gene.2011.06.004  0.466
2011 Sokol DK, Maloney B, Long JM, Ray B, Lahiri DK. Autism, Alzheimer disease, and fragile X: APP, FMRP, and mGluR5 are molecular links. Neurology. 76: 1344-52. PMID 21482951 DOI: 10.1212/Wnl.0B013E3182166Dc7  0.462
2011 Mathew LG, Maloney B, Takeda N, Mason HS. Spurious polyadenylation of Norovirus Narita 104 capsid protein mRNA in transgenic plants. Plant Molecular Biology. 75: 263-75. PMID 21203799 DOI: 10.1007/S11103-010-9725-1  0.307
2010 Lahiri DK, Maloney B. Beyond the signaling effect role of amyloid-ß42 on the processing of APP, and its clinical implications. Experimental Neurology. 225: 51-4. PMID 20451519 DOI: 10.1016/J.Expneurol.2010.04.018  0.465
2010 Lahiri DK, Maloney B. The "LEARn" (Latent Early-life Associated Regulation) model integrates environmental risk factors and the developmental basis of Alzheimer's disease, and proposes remedial steps. Experimental Gerontology. 45: 291-6. PMID 20064601 DOI: 10.1016/J.Exger.2010.01.001  0.454
2010 Maloney B, Ge YW, Petersen RC, Hardy J, Rogers JT, Pérez-Tur J, Lahiri DK. Functional characterization of three single-nucleotide polymorphisms present in the human APOE promoter sequence: Differential effects in neuronal cells and on DNA-protein interactions. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 153: 185-201. PMID 19504470 DOI: 10.1002/Ajmg.B.30973  0.429
2009 Lahiri DK, Maloney B, Zawia NH. The LEARn model: An epigenetic explanation for idiopathic neurobiological diseases Molecular Psychiatry. 14: 992-1003. PMID 19851280 DOI: 10.1038/Mp.2009.82  0.362
2009 Dosunmu R, Wu J, Adwan L, Maloney B, Basha MR, McPherson CA, Harry GJ, Rice DC, Zawia NH, Lahiri DK. Lifespan profiles of Alzheimer's disease-associated genes and products in monkeys and mice. Journal of Alzheimer's Disease : Jad. 18: 211-30. PMID 19584442 DOI: 10.3233/Jad-2009-1138  0.468
2009 Lahiri DK, Maloney B, Ray B, Rogers JT, Zawia N. S4-03-03: The “LEARn” (Latent Early-life Associated Regulation) model may explain the etiology of sporadic cases of Alzheimer's disease Alzheimer's & Dementia. 5: P146-P146. DOI: 10.1016/J.Jalz.2009.05.501  0.388
2008 Lahiri DK, Zawia NH, Greig NH, Sambamurti K, Maloney B. Early-life events may trigger biochemical pathways for Alzheimer's disease: the "LEARn" model. Biogerontology. 9: 375-9. PMID 18668339 DOI: 10.1007/S10522-008-9162-6  0.463
2008 Wen Y, Yu WH, Maloney B, Bailey J, Ma J, Marié I, Maurin T, Wang L, Figueroa H, Herman M, Krishnamurthy P, Liu L, Planel E, Lau LF, Lahiri DK, et al. Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing. Neuron. 57: 680-90. PMID 18341989 DOI: 10.1016/J.Neuron.2008.02.024  0.4
2008 Brock B, Basha R, DiPalma K, Anderson A, Harry GJ, Rice DC, Maloney B, Lahiri DK, Zawia NH. Co-localization and distribution of cerebral APP and SP1 and its relationship to amyloidogenesis. Journal of Alzheimer's Disease : Jad. 13: 71-80. PMID 18334759 DOI: 10.3233/Jad-2008-13108  0.423
2008 Wu J, Basha MR, Brock B, Cox DP, Cardozo-Pelaez F, McPherson CA, Harry J, Rice DC, Maloney B, Chen D, Lahiri DK, Zawia NH. Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): evidence for a developmental origin and environmental link for AD. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 3-9. PMID 18171917 DOI: 10.1523/Jneurosci.4405-07.2008  0.5
2008 Lahiri DK, Maloney B, Basha MR, Chen D, Zawia N. P3-234: Early-life environment affects expression of genes invoved in Alzheimer's disease by an epigenetic mechanism Alzheimer's & Dementia. 4: T589-T589. DOI: 10.1016/J.Jalz.2008.05.1801  0.409
2007 Maloney B, Ge YW, Alley GM, Lahiri DK. Important differences between human and mouse APOE gene promoters: limitation of mouse APOE model in studying Alzheimer's disease. Journal of Neurochemistry. 103: 1237-57. PMID 17854398 DOI: 10.1111/J.1471-4159.2007.04831.X  0.473
2007 Lahiri DK, Maloney B, Basha MR, Ge YW, Zawia NH. How and when environmental agents and dietary factors affect the course of Alzheimer's disease: the "LEARn" model (latent early-life associated regulation) may explain the triggering of AD. Current Alzheimer Research. 4: 219-28. PMID 17430250 DOI: 10.2174/156720507780362164  0.499
2007 Lahiri DK, Chen D, Maloney B, Holloway HW, Yu QS, Utsuki T, Giordano T, Sambamurti K, Greig NH. The experimental Alzheimer's disease drug posiphen [(+)-phenserine] lowers amyloid-beta peptide levels in cell culture and mice. The Journal of Pharmacology and Experimental Therapeutics. 320: 386-96. PMID 17003227 DOI: 10.1124/Jpet.106.112102  0.441
2006 Lahiri DK, Ge YW, Rogers JT, Sambamurti K, Greig NH, Maloney B. Taking down the unindicted co-conspirators of amyloid beta-peptide-mediated neuronal death: shared gene regulation of BACE1 and APP genes interacting with CREB, Fe65 and YY1 transcription factors. Current Alzheimer Research. 3: 475-83. PMID 17168646 DOI: 10.2174/156720506779025224  0.458
2006 Sokol DK, Chen D, Farlow MR, Dunn DW, Maloney B, Zimmer JA, Lahiri DK. High levels of Alzheimer beta-amyloid precursor protein (APP) in children with severely autistic behavior and aggression. Journal of Child Neurology. 21: 444-9. PMID 16948926 DOI: 10.1177/08830738060210062201  0.376
2006 Maloney B, Ge YW, Greig NH, Lahiri DK. Characterization of the human β-secretase 2 (BACE2) 5′-flanking region: Identification of a 268-bp region as the basal BACE2 promoter Journal of Molecular Neuroscience. 29: 81-99. PMID 16757812 DOI: 10.1385/Jmn:29:1:81  0.423
2006 Lahiri DK, Maloney B, Ge YW. Functional domains of the BACE1 and BACE2 promoters and mechanisms of transcriptional suppression of the BACE2 promoter in normal neuronal cells Journal of Molecular Neuroscience. 29: 65-80. PMID 16757811 DOI: 10.1385/Jmn:29:1:65  0.416
2006 Lahiri DK, Maloney B, Ge YW. BACE1 gene promoter is differentially regulated: Detection of a novel promoter region for its cell type-specific regulation Journal of Molecular Neuroscience. 28: 193-210. PMID 16679558 DOI: 10.1385/Jmn:28:2:193  0.481
2006 Bolin CM, Basha R, Cox D, Zawia NH, Maloney B, Lahiri DK, Cardozo-Pelaez F. Exposure to lead and the developmental origin of oxidative DNA damage in the aging brain. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 788-90. PMID 16484331 DOI: 10.1096/Fj.05-5091Fje  0.351
2006 Wang R, Maloney B, Lahiri DK. P2-269: ROLE OF THE REPRESSOR ELEMENT 1-SILENCING TRANSCRIPTION FACTOR (REST) IN NEURONAL DIFFERENTIATION AND ITS IMPLICATION IN ALZHEIMER'S DISEASE (AD) Alzheimer's & Dementia. 14: P780-P780. DOI: 10.1016/J.Jalz.2018.06.958  0.436
2006 Lahiri DK, Chopra N, Maloney B, Greig NH, Chakrabarti S. P3-061: CONSTITUTIVE IN VIVO OVEREXPRESSION OF MIR146A AND MIR200B INDEPENDENTLY MODULATES LEVELS OF ALZHEIMER'S DISEASE (AD)- RELATED PROTEINS IN THE MOUSE HIPPOCAMPUS AND CEREBRAL CORTEX Alzheimer's & Dementia. 14: P1088-P1088. DOI: 10.1016/J.Jalz.2018.06.1417  0.435
2006 Lahiri DK, Ge Y, Basha MR, Maloney B, Chen D, Zawia N. S2-01-06: Genetics & epigenetic studies in AD Alzheimer's & Dementia. 2: S24-S24. DOI: 10.1016/J.Jalz.2006.05.079  0.372
2006 Sokol D, Maloney B, Kardatzke D, Chen D, Lahiri D. [P128]: Role of two Alzheimer's disease protein markers: Amyloid precursor protein and acetylcholinesterase with aggression in autism International Journal of Developmental Neuroscience. 24: 551-551. DOI: 10.1016/J.Ijdevneu.2006.09.190  0.433
2005 Lahiri DK, Ge YW, Maloney B, Wavrant-De Vrièze F, Hardy J. Characterization of two APP gene promoter polymorphisms that appear to influence risk of late-onset Alzheimer's disease Neurobiology of Aging. 26: 1329-1341. PMID 16243604 DOI: 10.1016/J.Neurobiolaging.2004.11.005  0.474
2005 Du Y, Chen X, Wei X, Bales KR, Berg DT, Paul SM, Farlow MR, Maloney B, Ge YW, Lahiri DK. NF-(kappa)B mediates amyloid beta peptide-stimulated activity of the human apolipoprotein E gene promoter in human astroglial cells. Brain Research. Molecular Brain Research. 136: 177-88. PMID 15893602 DOI: 10.1016/J.Molbrainres.2005.02.001  0.385
2005 Lahiri DK, Ge YW, Maloney B. Characterization of the APP proximal promoter and 5′-untranslated regions: Identification or cell type-specific domains and implications in APP gene expression and Alzheimer's disease Faseb Journal. 19: 653-655. PMID 15703276 DOI: 10.1096/Fj.04-2900Fje  0.461
2004 Ge YW, Ghosh C, Song W, Maloney B, Lahiri DK. Mechanism of promoter activity of the beta-amyloid precursor protein gene in different cell lines: identification of a specific 30 bp fragment in the proximal promoter region. Journal of Neurochemistry. 90: 1432-44. PMID 15341527 DOI: 10.1111/J.1471-4159.2004.02608.X  0.469
2004 Maloney B, Ge YW, Greig N, Lahiri DK. Presence of a "CAGA box" in the APP gene unique to amyloid plaque-forming species and absent in all APLP-1/2 genes: Implications in Alzheimer's disease Faseb Journal. 18: 1288-1290. PMID 15208260 DOI: 10.1096/Fj.03-1703Fje  0.483
2004 Ge YW, Maloney B, Sambamurti K, Lahiri DK. Functional characterization of the 5' flanking region of the BACE gene: identification of a 91 bp fragment involved in basal level of BACE promoter expression. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1037-9. PMID 15059977 DOI: 10.1096/Fj.03-1379Fje  0.41
2004 Sambamurti K, Kinsey R, Maloney B, Ge YW, Lahiri DK. Gene structure and organization of the human beta-secretase (BACE) promoter. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1034-6. PMID 15059975 DOI: 10.1096/Fj.03-1378Fje  0.446
2004 Bellingham SA, Lahiri DK, Maloney B, La Fontaine S, Multhaup G, Camakaris J. Copper depletion down-regulates expression of the Alzheimer's disease amyloid-beta precursor protein gene. The Journal of Biological Chemistry. 279: 20378-86. PMID 14985339 DOI: 10.1074/Jbc.M400805200  0.46
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