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Michael M. Gottesman - Publications

Affiliations: 
Cell Biology National Cancer Institute, Rockville, MD, United States 
Area:
resistance of cancer cells to anticancer drugs
Website:
https://ccr.cancer.gov/Laboratory-of-Cell-Biology/michael-m-gottesman
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344 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Robey RW, Fitzsimmons CM, Guiblet WM, Frye WJE, González Dalmasy JM, Wang L, Russell DA, Huff LM, Perciaccante AJ, Ali-Rahmani F, Lipsey CC, Wade HM, Mitchell AV, Maligireddy SS, Terrero D, ... ... Gottesman MM, et al. The methyltransferases METTL7A and METTL7B confer resistance to thiol-based histone deacetylase inhibitors. Molecular Cancer Therapeutics. PMID 38151817 DOI: 10.1158/1535-7163.MCT-23-0144  0.353
2023 Gerard L, Duviver L, Fourrez M, Salazar P, Sprimont L, Xia D, Ambudkar SV, Gottesman MM, Gillet JP. Identification of two novel heterodimeric ABC transporters in melanoma: ABCB5β/B6 and ABCB5β/B9. The Journal of Biological Chemistry. 105594. PMID 38145744 DOI: 10.1016/j.jbc.2023.105594  0.336
2023 Thomas JR, Frye WJE, Robey RW, Gottesman MM. Progress in characterizing ABC multidrug transporters in zebrafish. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 72: 101035. PMID 38141369 DOI: 10.1016/j.drup.2023.101035  0.347
2023 González Dalmasy JM, Fitzsimmons CM, Frye WJE, Perciaccante AJ, Jewell CP, Jenkins LM, Batista PJ, Robey RW, Gottesman MM. The thiol methyltransferase activity of TMT1A (METTL7A) is conserved across species. Biorxiv : the Preprint Server For Biology. PMID 38076968 DOI: 10.1101/2023.11.17.567538  0.312
2023 Gottesman MM, Robey RW, Ambudkar SV. New mechanisms of multidrug resistance: an introduction to the special collection. Cancer Drug Resistance (Alhambra, Calif.). 6: 590-595. PMID 37842242 DOI: 10.20517/cdr.2023.86  0.313
2023 Frye WJE, Huff LM, González Dalmasy JM, Salazar P, Carter RM, Gensler RT, Esposito D, Robey RW, Ambudkar SV, Gottesman MM. The multidrug resistance transporter P-glycoprotein confers resistance to ferroptosis inducers. Cancer Drug Resistance (Alhambra, Calif.). 6: 468-480. PMID 37840856 DOI: 10.20517/cdr.2023.29  0.345
2023 Alyateem G, Wade HM, Bickert AA, Lipsey CC, Mondal P, Smith MD, Labib RM, Mock BA, Robey RW, Gottesman MM. Use of CRISPR-based screens to identify mechanisms of chemotherapy resistance. Cancer Gene Therapy. PMID 37029320 DOI: 10.1038/s41417-023-00608-z  0.351
2023 Frye WJE, Huff LM, González Dalmasy JM, Salazar P, Carter RM, Gensler RT, Esposito D, Robey RW, Ambudkar SV, Gottesman MM. The Multidrug Resistance Transporter P-glycoprotein Confers Resistance to Ferroptosis Inducers. Biorxiv : the Preprint Server For Biology. PMID 36945397 DOI: 10.1101/2023.02.23.529736  0.357
2020 Sajid A, Lusvarghi S, Murakami M, Chufan EE, Abel B, Gottesman MM, Durell SR, Ambudkar SV. Reversing the direction of drug transport mediated by the human multidrug transporter P-glycoprotein. Proceedings of the National Academy of Sciences of the United States of America. PMID 33168729 DOI: 10.1073/pnas.2016270117  0.331
2020 Patel RP, Kuhn S, Yin D, Hotz J, Maher FA, Robey RW, Gottesman MM, Horibata S. Cross-resistance of cisplatin selected cells to anti-microtubule agents: Role of general survival mechanisms. Translational Oncology. 14: 100917. PMID 33129114 DOI: 10.1016/j.tranon.2020.100917  0.362
2020 Lipsey CC, Harbuzariu A, Robey RW, Huff LM, Gottesman MM, Gonzalez-Perez RR. Leptin Signaling Affects Survival and Chemoresistance of Estrogen Receptor Negative Breast Cancer. International Journal of Molecular Sciences. 21. PMID 32471192 DOI: 10.3390/Ijms21113794  0.331
2020 Horibata S, Alyateem G, DeStefano CB, Gottesman MM. The Evolving AML Genomic Landscape: Therapeutic Implications. Current Cancer Drug Targets. PMID 32329691 DOI: 10.2174/1568009620666200424150321  0.323
2020 Hall MD, Marshall TS, Kwit ADT, Miller Jenkins LM, Dulcey AE, Madigan JP, Pluchino KM, Goldsborough AS, Brimacombe KR, Griffiths GL, Gottesman MM. Correction: Inhibition of glutathione peroxidase mediates the collateral sensitivity of multidrug-resistant cells to tiopronin. The Journal of Biological Chemistry. 295: 4370. PMID 32221035 DOI: 10.1074/jbc.AAC120.013256  0.322
2020 Lusvarghi S, Robey RW, Gottesman MM, Ambudkar SV. Multidrug transporters: recent insights from cryo-electron microscopy-derived atomic structures and animal models. F1000research. 9. PMID 32055397 DOI: 10.12688/F1000Research.21295.1  0.414
2020 Goldsborough AS, Handley MD, Dulcey AE, Pluchino KM, Kannan P, Brimacombe KR, Hall MD, Griffiths G, Gottesman MM. Retraction of "Collateral Sensitivity of Multidrug-Resistant Cells to the Orphan Drug Tiopronin". Journal of Medicinal Chemistry. PMID 32013420 DOI: 10.1021/Acs.Jmedchem.9B01794  0.448
2020 Madigan JP, Robey RW, Poprawski JE, Huang H, Clarke CJ, Gottesman MM, Cabot MC, Rosenberg DW. A role for ceramide glycosylation in resistance to oxaliplatin in colorectal cancer. Experimental Cell Research. 111860. PMID 31972222 DOI: 10.1016/J.Yexcr.2020.111860  0.465
2019 Huff LM, Horibata S, Robey RW, Hall MD, Gottesman MM. Mycoplasma Infection Mediates Sensitivity of Multidrug-Resistant Cell Lines to Tiopronin: A Cautionary Tale. Journal of Medicinal Chemistry. PMID 31702923 DOI: 10.1021/Acs.Jmedchem.9B00484  0.449
2019 Lee TD, Lee OW, Brimacombe KR, Chen L, Guha R, Lusvarghi S, Tebase BG, Klumpp-Thomas C, Robey RW, Ambudkar SV, Shen M, Gottesman MM, Hall MD. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular Pharmacology. PMID 31515284 DOI: 10.1124/Mol.119.115964  0.379
2019 Baglo Y, Liang BJ, Robey RW, Ambudkar SV, Gottesman MM, Huang HC. Porphyrin-lipid Assemblies and Nanovesicles Overcome ABC Transporter-Mediated Photodynamic Therapy Resistance in Cancer Cells. Cancer Letters. PMID 31071369 DOI: 10.1016/J.Canlet.2019.04.037  0.424
2019 Horibata S, Gui G, Lack J, DeStefano CB, Gottesman MM, Hourigan CS. Heterogeneity in refractory acute myeloid leukemia. Proceedings of the National Academy of Sciences of the United States of America. PMID 31064876 DOI: 10.1073/Pnas.1902375116  0.357
2019 Robinson AN, Tebase BG, Francone SC, Huff LM, Kozlowski H, Cossari D, Lee JM, Esposito D, Robey RW, Gottesman MM. Co-expression of ABCB1 and ABCG2 in a Cell Line Model Reveals Both Independent and Additive Transporter Function. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 31048454 DOI: 10.1124/Dmd.118.086181  0.466
2019 Robinson A, Robey R, Gottesman M. Abstract 1266: Co-expression of P-glycoprotein and ABCG2 in a cell line model reveals both independent and cooperative transporter function Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-1266  0.4
2019 Meeks C, Vezina A, Robey R, Gottesman M, Jackson S. EXTH-19. IBRUTINIB MODULATES BLOOD-BRAIN BARRIER INTEGRITY TO ENHANCE CHEMOTHERAPY PERMEABILITY Neuro-Oncology. 21: vi86-vi86. DOI: 10.1093/Neuonc/Noz175.353  0.361
2018 McDonald AJ, Curt KM, Patel RP, Kozlowski H, Sackett DL, Robey RW, Gottesman MM, Bates SE. Targeting mitochondrial hexokinases increases efficacy of histone deacetylase inhibitors in solid tumor models. Experimental Cell Research. PMID 30579954 DOI: 10.1016/J.Yexcr.2018.12.012  0.341
2018 Vahedi S, Lusvarghi S, Pluchino K, Shafrir Y, Durell SR, Gottesman MM, Ambudkar SV. Mapping discontinuous epitopes for MRK-16, UIC2 and 4E3 antibodies to extracellular loops 1 and 4 of human P-glycoprotein. Scientific Reports. 8: 12716. PMID 30143707 DOI: 10.1038/S41598-018-30984-8  0.374
2018 Chen KG, Mallon BS, Park K, Robey PG, McKay RDG, Gottesman MM, Zheng W. Pluripotent Stem Cell Platforms for Drug Discovery. Trends in Molecular Medicine. PMID 30006147 DOI: 10.1016/J.Molmed.2018.06.009  0.64
2018 Robey RW, Pluchino KM, Hall MD, Fojo AT, Bates SE, Gottesman MM. Revisiting the role of ABC transporters in multidrug-resistant cancer. Nature Reviews. Cancer. PMID 29643473 DOI: 10.1038/S41568-018-0005-8  0.471
2016 Esser L, Zhou F, Pluchino KM, Shiloach J, Ma J, Tang WK, Gutierrez C, Zhang A, Shukla S, Madigan JP, Zhou T, Kwong PD, Ambudkar SV, Gottesman MM, Xia D. Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity. The Journal of Biological Chemistry. PMID 27864369 DOI: 10.1074/Jbc.M116.755884  0.353
2016 Bahr JC, Robey RW, Luchenko V, Basseville A, Chakraborty AR, Kozlowski H, Pauly GT, Patel P, Schneider JP, Gottesman MM, Bates SE. Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras. Oncotarget. PMID 27634878 DOI: 10.18632/Oncotarget.12001  0.316
2016 Bakhsheshian J, Wei BR, Hall MD, Simpson RM, Gottesman MM. In Vivo Bioluminescent Imaging of ATP-Binding Cassette Transporter-Mediated Efflux at the Blood-Brain Barrier. Methods in Molecular Biology (Clifton, N.J.). 1461: 227-39. PMID 27424909 DOI: 10.1007/978-1-4939-3813-1_19  0.31
2016 Liow JS, Zoghbi SS, Hu S, Hall MD, Hines CS, Shetty HU, Araneta MD, Page EM, Pike VW, Kreisl WC, Herscovitch P, Gottesman MM, Theodore WH, Innis RB. (18)F-FCWAY, a serotonin 1A receptor radioligand, is a substrate for efflux transport at the human blood-brain barrier. Neuroimage. PMID 27211474 DOI: 10.1016/J.Neuroimage.2016.05.045  0.354
2016 Frank G, Shukla S, Rao P, Borgnia MJ, Bartesaghi A, Merk A, Mobin A, Esser L, Earl LA, Gottesman MM, Xia D, Ambudkar SV, Subramaniam S. Cryo-EM analysis of the conformational landscape of human P-glycoprotein (ABCB1) during its catalytic cycle. Molecular Pharmacology. PMID 27190212 DOI: 10.1124/Mol.116.104190  0.377
2016 Greene JM, Levy D, Herrada SP, Gottesman MM, Lavi O. Mathematical modeling reveals that changes to local cell density dynamically modulate baseline variations in cell growth and drug response. Cancer Research. PMID 26933088 DOI: 10.1158/0008-5472.Can-15-3232  0.378
2016 Kumar JS, Wei BR, Madigan JP, Simpson RM, Hall MD, Gottesman MM. Bioluminescent imaging of ABCG2 efflux activity at the blood-placenta barrier. Scientific Reports. 6: 20418. PMID 26853103 DOI: 10.1038/Srep20418  0.347
2016 Pluchino KM, Hall MD, Moen JK, Chufán EE, Fetsch PA, Shukla S, Gill DR, Hyde SC, Xia D, Ambudkar SV, Gottesman MM. Human-Mouse Chimeras With Normal Expression and Function Reveal That Major Domain Swapping is Tolerated by P-glycoprotein (ABCB1). Biochemistry. PMID 26820614 DOI: 10.1021/Acs.Biochem.5B01064  0.401
2015 Weidner LD, Fung KL, Kannan P, Moen JK, Kumar JS, Mulder J, Innis RB, Gottesman MM, Hall M. Tariquidar is an Inhibitor and Not a Substrate of Human and Mouse P-glycoprotein. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 26658428 DOI: 10.1124/Dmd.115.067785  0.379
2015 Fung KL, Kapoor K, Pixley JN, Talbert DJ, Kwit AD, Ambudkar SV, Gottesman M. Using the BacMam Baculovirus System to Study Expression and Function of Recombinant Efflux Drug Transporters in Polarized Epithelial Cell Monolayers. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 26622052 DOI: 10.1124/Dmd.115.066506  0.461
2015 Jagodinsky JC, Sulima A, Cao Y, Poprawski JE, Blackman BN, Lloyd JR, Swenson RE, Gottesman MM, Hall MD. Evaluation of fluorophore-tethered platinum complexes to monitor the fate of cisplatin analogs. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 20: 1081-95. PMID 26323351 DOI: 10.1007/S00775-015-1290-2  0.358
2015 Pluchino KM, Esposito D, Moen JK, Hall MD, Madigan JP, Shukla S, Procter LV, Wall VE, Schneider TD, Pringle I, Ambudkar SV, Gill DR, Hyde SC, Gottesman MM. Identification of a Cryptic Bacterial Promoter in Mouse (mdr1a) P-Glycoprotein cDNA. Plos One. 10: e0136396. PMID 26309032 DOI: 10.1371/Journal.Pone.0136396  0.405
2015 Gottesman MM, Pastan IH. The Role of Multidrug Resistance Efflux Pumps in Cancer: Revisiting a JNCI Publication Exploring Expression of the MDR1 (P-glycoprotein) Gene. Journal of the National Cancer Institute. 107. PMID 26286731 DOI: 10.1093/jnci/djv222  0.318
2015 Weidner LD, Zoghbi SS, Lu S, Shukla S, Ambudkar SV, Pike VW, Mulder J, Gottesman MM, Innis RB, Hall MD. The Inhibitor Ko143 Is Not Specific for ABCG2. The Journal of Pharmacology and Experimental Therapeutics. 354: 384-93. PMID 26148857 DOI: 10.1124/Jpet.115.225482  0.346
2015 Souza PS, Madigan JP, Gillet JP, Kapoor K, Ambudkar SV, Maia RC, Gottesman MM, Leung Fung K. Expression of the multidrug transporter P-glycoprotein is inversely related to that of apoptosis-associated endogenous TRAIL. Experimental Cell Research. PMID 26101157 DOI: 10.1016/j.yexcr.2015.06.005  0.325
2015 Stukova M, Hall MD, Tsotsoros SD, Madigan JP, Farrell NP, Gottesman MM. Reduced accumulation of platinum drugs is not observed in drug-resistant ovarian cancer cell lines derived from cisplatin-treated patients. Journal of Inorganic Biochemistry. 149: 45-8. PMID 26021697 DOI: 10.1016/J.Jinorgbio.2015.05.003  0.462
2015 Greene JM, Levy D, Fung KL, Souza PS, Gottesman MM, Lavi O. Modeling intrinsic heterogeneity and growth of cancer cells. Journal of Theoretical Biology. 367: 262-77. PMID 25457229 DOI: 10.1016/J.Jtbi.2014.11.017  0.392
2015 Chang KE, Wei BR, Madigan JP, Hall MD, Simpson RM, Zhuang Z, Gottesman MM. The protein phosphatase 2A inhibitor LB100 sensitizes ovarian carcinoma cells to cisplatin-mediated cytotoxicity. Molecular Cancer Therapeutics. 14: 90-100. PMID 25376608 DOI: 10.1158/1535-7163.Mct-14-0496  0.42
2014 Padmanabhan R, Chen KG, Gottesman MM. Lost in Translation: Regulation of ABCG2 Expression in Human Embryonic Stem Cells. Journal of Stem Cell Research & Therapy. 4. PMID 25405071 DOI: 10.4172/2157-7633.1000180  0.644
2014 Keniya MV, Holmes AR, Niimi M, Lamping E, Gillet JP, Gottesman MM, Cannon RD. Drug resistance is conferred on the model yeast Saccharomyces cerevisiae by expression of full-length melanoma-associated human ATP-binding cassette transporter ABCB5. Molecular Pharmaceutics. 11: 3452-62. PMID 25115303 DOI: 10.1021/Mp500230B  0.466
2014 Lavi O, Skinner J, Gottesman MM. Network features suggest new hepatocellular carcinoma treatment strategies. Bmc Systems Biology. 8: 88. PMID 25070212 DOI: 10.1186/S12918-014-0088-0  0.353
2014 Hall MD, Marshall TS, Kwit AD, Miller Jenkins LM, Dulcey AE, Madigan JP, Pluchino KM, Goldsborough AS, Brimacombe KR, Griffiths GL, Gottesman MM. Inhibition of glutathione peroxidase mediates the collateral sensitivity of multidrug-resistant cells to tiopronin. The Journal of Biological Chemistry. 289: 21473-89. PMID 24930045 DOI: 10.1074/Jbc.M114.581702  0.496
2014 Hall MD, Telma KA, Chang KE, Lee TD, Madigan JP, Lloyd JR, Goldlust IS, Hoeschele JD, Gottesman MM. Say no to DMSO: dimethylsulfoxide inactivates cisplatin, carboplatin, and other platinum complexes. Cancer Research. 74: 3913-22. PMID 24812268 DOI: 10.1158/0008-5472.Can-14-0247  0.324
2014 Fung KL, Tepede AK, Pluchino KM, Pouliot LM, Pixley JN, Hall MD, Gottesman MM. Uptake of compounds that selectively kill multidrug-resistant cells: the copper transporter SLC31A1 (CTR1) increases cellular accumulation of the thiosemicarbazone NSC73306. Molecular Pharmaceutics. 11: 2692-702. PMID 24800945 DOI: 10.1021/Mp500114E  0.797
2014 Szakács G, Hall MD, Gottesman MM, Boumendjel A, Kachadourian R, Day BJ, Baubichon-Cortay H, Di Pietro A. Targeting the Achilles heel of multidrug-resistant cancer by exploiting the fitness cost of resistance. Chemical Reviews. 114: 5753-74. PMID 24758331 DOI: 10.1021/Cr4006236  0.505
2014 Greene J, Lavi O, Gottesman MM, Levy D. The impact of cell density and mutations in a model of multidrug resistance in solid tumors. Bulletin of Mathematical Biology. 76: 627-53. PMID 24553772 DOI: 10.1007/S11538-014-9936-8  0.403
2014 Lavi O, Greene JM, Levy D, Gottesman MM. Simplifying the complexity of resistance heterogeneity in metastasis. Trends in Molecular Medicine. 20: 129-36. PMID 24491979 DOI: 10.1016/J.Molmed.2013.12.005  0.381
2014 Doherty B, Lawlor D, Gillet JP, Gottesman M, O'Leary JJ, Stordal B. Collateral sensitivity to cisplatin in KB-8-5-11 drug-resistant cancer cells. Anticancer Research. 34: 503-7. PMID 24403508  0.349
2014 Fung KL, Pan J, Ohnuma S, Lund PE, Pixley JN, Kimchi-Sarfaty C, Ambudkar SV, Gottesman MM. MDR1 synonymous polymorphisms alter transporter specificity and protein stability in a stable epithelial monolayer. Cancer Research. 74: 598-608. PMID 24305879 DOI: 10.1158/0008-5472.Can-13-2064  0.408
2014 Galski H, Oved-Gelber T, Simanovsky M, Lazarovici P, Gottesman MM, Nagler A. Corrigendum to "P-glycoprotein-dependent resistance of cancer cells toward the extrinsic TRAIL apoptosis signaling pathway" [Biochem. Pharmacol. 86 (2013) 584-596] Biochemical Pharmacology. 92: 518. DOI: 10.1016/J.Bcp.2014.08.020  0.39
2013 Bakhsheshian J, Wei BR, Chang KE, Shukla S, Ambudkar SV, Simpson RM, Gottesman MM, Hall MD. Bioluminescent imaging of drug efflux at the blood-brain barrier mediated by the transporter ABCG2. Proceedings of the National Academy of Sciences of the United States of America. 110: 20801-6. PMID 24297888 DOI: 10.1073/Pnas.1312159110  0.344
2013 Xue X, Hall MD, Zhang Q, Wang PC, Gottesman MM, Liang XJ. Nanoscale drug delivery platforms overcome platinum-based resistance in cancer cells due to abnormal membrane protein trafficking. Acs Nano. 7: 10452-64. PMID 24219825 DOI: 10.1021/Nn405004F  0.473
2013 Lavi O, Greene JM, Levy D, Gottesman MM. The role of cell density and intratumoral heterogeneity in multidrug resistance. Cancer Research. 73: 7168-75. PMID 24163380 DOI: 10.1158/0008-5472.Can-13-1768  0.414
2013 Jaeger AA, Das CK, Morgan NY, Pursley RH, McQueen PG, Hall MD, Pohida TJ, Gottesman MM. Microfabricated polymeric vessel mimetics for 3-D cancer cell culture. Biomaterials. 34: 8301-13. PMID 23911071 DOI: 10.1016/J.Biomaterials.2013.07.013  0.328
2013 Bakhsheshian J, Hall MD, Robey RW, Herrmann MA, Chen JQ, Bates SE, Gottesman MM. Overlapping substrate and inhibitor specificity of human and murine ABCG2. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 1805-12. PMID 23868912 DOI: 10.1124/Dmd.113.053140  0.417
2013 Galski H, Oved-Gelber T, Simanovsky M, Lazarovici P, Gottesman MM, Nagler A. P-glycoprotein-dependent resistance of cancer cells toward the extrinsic TRAIL apoptosis signaling pathway. Biochemical Pharmacology. 86: 584-96. PMID 23774624 DOI: 10.1016/J.Bcp.2013.06.004  0.448
2013 Patel C, Stenke L, Varma S, Lindberg ML, Björkholm M, Sjöberg J, Viktorsson K, Lewensohn R, Landgren O, Gottesman MM, Gillet JP. Multidrug resistance in relapsed acute myeloid leukemia: evidence of biological heterogeneity. Cancer. 119: 3076-83. PMID 23674237 DOI: 10.1002/Cncr.28098  0.374
2013 Kannan P, Pike VW, Halldin C, Langer O, Gottesman MM, Innis RB, Hall MD. Factors that limit positron emission tomography imaging of p-glycoprotein density at the blood-brain barrier. Molecular Pharmaceutics. 10: 2222-9. PMID 23597242 DOI: 10.1021/Mp400011G  0.308
2013 Chakraborty AR, Robey RW, Luchenko VL, Zhan Z, Piekarz RL, Gillet JP, Kossenkov AV, Wilkerson J, Showe LC, Gottesman MM, Collie NL, Bates SE. MAPK pathway activation leads to Bim loss and histone deacetylase inhibitor resistance: rationale to combine romidepsin with an MEK inhibitor. Blood. 121: 4115-25. PMID 23532732 DOI: 10.1182/Blood-2012-08-449140  0.457
2013 Gillet JP, Varma S, Gottesman MM. The clinical relevance of cancer cell lines. Journal of the National Cancer Institute. 105: 452-8. PMID 23434901 DOI: 10.1093/Jnci/Djt007  0.325
2013 Pouliot LM, Shen DW, Suzuki T, Hall MD, Gottesman MM. Contributions of microRNA dysregulation to cisplatin resistance in adenocarcinoma cells. Experimental Cell Research. 319: 566-74. PMID 23137650 DOI: 10.1016/J.Yexcr.2012.10.012  0.795
2013 Fung KL, Pixley J, Talbert DJ, Kapoor K, Ambudkar S, Gottesman MM. Abstract 989: Mild ER stress increases human ABC transporter expression and drug transport function in polarized cell monolayers. Cancer Research. 73: 989-989. DOI: 10.1158/1538-7445.Am2013-989  0.448
2013 Gillet J, Andersen JB, Madigan JP, Varma S, Wu C, Calcagno AM, Ambudkar SV, Thorgeirsson SS, Gottesman MM. Abstract 954: Multidrug resistance transcriptome analysis highlights compounds that sensitize resistant hepatocellular carcinoma through increased histone acetylation. Cancer Research. 73: 954-954. DOI: 10.1158/1538-7445.Am2013-954  0.355
2013 Bakhsheshian J, Kwit ADT, Brimacombe KR, Hall MD, Gottesman MM. Abstract 944: The effect of endogenous peroxidase activity on cell culture-based drug activity screening. Cancer Research. 73: 944-944. DOI: 10.1158/1538-7445.Am2013-944  0.379
2013 Chakraborty AR, Robey R, Zhan Z, Luchenko V, Gottesman M, Collie N, Gillet J, Piekarz R, Kossenkov A, Showe L, Bates S. Abstract 3399: Resistance to the histone deacetylase inhibitor romidepsin is associated with degradation of Bim following MAPK pathway activation. Cancer Research. 73: 3399-3399. DOI: 10.1158/1538-7445.Am2013-3399  0.443
2012 Kimchi-Sarfaty C, Gottesman MM. SV40 in vitro packaging: a pseudovirion gene delivery system. Cold Spring Harbor Protocols. 2012: 1019-23. PMID 22949719 DOI: 10.1101/Pdb.Prot071043  0.344
2012 Pouliot LM, Chen YC, Bai J, Guha R, Martin SE, Gottesman MM, Hall MD. Cisplatin sensitivity mediated by WEE1 and CHK1 is mediated by miR-155 and the miR-15 family. Cancer Research. 72: 5945-55. PMID 22942255 DOI: 10.1158/0008-5472.Can-12-1400  0.787
2012 Padmanabhan R, Chen KG, Gillet JP, Handley M, Mallon BS, Hamilton RS, Park K, Varma S, Mehaffey MG, Robey PG, McKay RD, Gottesman MM. Regulation and expression of the ATP-binding cassette transporter ABCG2 in human embryonic stem cells. Stem Cells (Dayton, Ohio). 30: 2175-87. PMID 22887864 DOI: 10.1002/Stem.1195  0.654
2012 Stordal B, Hamon M, McEneaney V, Roche S, Gillet JP, O'Leary JJ, Gottesman M, Clynes M. Resistance to paclitaxel in a cisplatin-resistant ovarian cancer cell line is mediated by P-glycoprotein. Plos One. 7: e40717. PMID 22792399 DOI: 10.1371/Journal.Pone.0040717  0.505
2012 Shen DW, Pouliot LM, Hall MD, Gottesman MM. Cisplatin resistance: a cellular self-defense mechanism resulting from multiple epigenetic and genetic changes. Pharmacological Reviews. 64: 706-21. PMID 22659329 DOI: 10.1124/Pr.111.005637  0.808
2012 Shen DW, Pouliot LM, Gillet JP, Ma W, Johnson AC, Hall MD, Gottesman MM. The transcription factor GCF2 is an upstream repressor of the small GTPAse RhoA, regulating membrane protein trafficking, sensitivity to doxorubicin, and resistance to cisplatin. Molecular Pharmaceutics. 9: 1822-33. PMID 22571463 DOI: 10.1021/Mp300153Z  0.82
2012 Gillet JP, Calcagno AM, Varma S, Davidson B, Bunkholt Elstrand M, Ganapathi R, Kamat AA, Sood AK, Ambudkar SV, Seiden MV, Rueda BR, Gottesman MM. Multidrug resistance-linked gene signature predicts overall survival of patients with primary ovarian serous carcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 3197-206. PMID 22492981 DOI: 10.1158/1078-0432.Ccr-12-0056  0.364
2012 Pluchino KM, Hall MD, Goldsborough AS, Callaghan R, Gottesman MM. Collateral sensitivity as a strategy against cancer multidrug resistance. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 15: 98-105. PMID 22483810 DOI: 10.1016/J.Drup.2012.03.002  0.482
2012 Gillet JP, Gottesman MM. Overcoming multidrug resistance in cancer: 35 years after the discovery of ABCB1. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 15: 2-4. PMID 22465109 DOI: 10.1016/J.Drup.2012.03.001  0.38
2012 Shaffer BC, Gillet JP, Patel C, Baer MR, Bates SE, Gottesman MM. Drug resistance: still a daunting challenge to the successful treatment of AML. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 15: 62-9. PMID 22409994 DOI: 10.1016/J.Drup.2012.02.001  0.464
2012 Rottenberg S, Vollebergh MA, de Hoon B, de Ronde J, Schouten PC, Kersbergen A, Zander SA, Pajic M, Jaspers JE, Jonkers M, Lodén M, Sol W, van der Burg E, Wesseling J, Gillet JP, ... Gottesman MM, et al. Impact of intertumoral heterogeneity on predicting chemotherapy response of BRCA1-deficient mammary tumors. Cancer Research. 72: 2350-61. PMID 22396490 DOI: 10.1158/0008-5472.Can-11-4201  0.331
2012 Lavi O, Gottesman MM, Levy D. The dynamics of drug resistance: a mathematical perspective. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 15: 90-7. PMID 22387162 DOI: 10.1016/J.Drup.2012.01.003  0.437
2012 Shen DW, Gottesman MM. RAB8 enhances TMEM205-mediated cisplatin resistance. Pharmaceutical Research. 29: 643-50. PMID 21969054 DOI: 10.1007/S11095-011-0562-Y  0.483
2012 Pouliot LM, Bai J, Hall MD, Martin SE, Gottesman MM. Abstract B12: The miR-15 family and miR-155 mediate WEE1 and CHEK1 effects on cisplatin-resistance in cancer cells Cancer Research. 72: B12-B12. DOI: 10.1158/1538-7445.Nonrna12-B12  0.791
2012 Fung KL, Tepede AK, Pluchino KM, Hall MD, Gottesman MM. Abstract 843: Influx of thiosemicarbazone NSC73306 is mediated by the cisplatin and copper transporter SLC31A1 (CTR1) Cancer Research. 72: 843-843. DOI: 10.1158/1538-7445.Am2012-843  0.489
2012 Chakraborty A, Robey R, Gillet J, Luchenko V, Piekarz R, Gottesman M, Collie N, Bates S. Abstract B9: Activated MAPK Pathway Mediates Resistance to Romidepsin via Bim Degradation in Romidepsin-Selected HuT 78 Cells Clinical Cancer Research. 18: B9-B9. DOI: 10.1158/1078-0432.Mechres-B9  0.481
2011 Kannan P, Telu S, Shukla S, Ambudkar SV, Pike VW, Halldin C, Gottesman MM, Innis RB, Hall MD. The "specific" P-glycoprotein inhibitor Tariquidar is also a substrate and an inhibitor for breast cancer resistance protein (BCRP/ABCG2). Acs Chemical Neuroscience. 2: 82-9. PMID 22778859 DOI: 10.1021/Cn100078A  0.387
2011 Gillet JP, Calcagno AM, Varma S, Marino M, Green LJ, Vora MI, Patel C, Orina JN, Eliseeva TA, Singal V, Padmanabhan R, Davidson B, Ganapathi R, Sood AK, Rueda BR, ... ... Gottesman MM, et al. Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance. Proceedings of the National Academy of Sciences of the United States of America. 108: 18708-13. PMID 22068913 DOI: 10.1073/Pnas.1111840108  0.409
2011 Lucia MB, Anu R, Handley M, Gillet JP, Wu CP, De Donatis GM, Cauda R, Gottesman MM. Exposure to HIV-protease inhibitors selects for increased expression of P-glycoprotein (ABCB1) in Kaposi's sarcoma cells. British Journal of Cancer. 105: 513-22. PMID 21829205 DOI: 10.1038/Bjc.2011.275  0.404
2011 Gillet JP, Wang J, Calcagno AM, Green LJ, Varma S, Bunkholt Elstrand M, Trope CG, Ambudkar SV, Davidson B, Gottesman MM. Clinical relevance of multidrug resistance gene expression in ovarian serous carcinoma effusions. Molecular Pharmaceutics. 8: 2080-8. PMID 21761824 DOI: 10.1021/Mp200240A  0.345
2011 Hall MD, Brimacombe KR, Varonka MS, Pluchino KM, Monda JK, Li J, Walsh MJ, Boxer MB, Warren TH, Fales HM, Gottesman MM. Synthesis and structure-activity evaluation of isatin-β-thiosemicarbazones with improved selective activity toward multidrug-resistant cells expressing P-glycoprotein. Journal of Medicinal Chemistry. 54: 5878-89. PMID 21721528 DOI: 10.1021/Jm2006047  0.4
2011 Goldsborough AS, Handley MD, Dulcey AE, Pluchino KM, Kannan P, Brimacombe KR, Hall MD, Griffiths G, Gottesman MM. Collateral sensitivity of multidrug-resistant cells to the orphan drug tiopronin. Journal of Medicinal Chemistry. 54: 4987-97. PMID 21657271 DOI: 10.1021/Jm2001663  0.461
2011 Shukla S, Skoumbourdis AP, Walsh MJ, Hartz AM, Fung KL, Wu CP, Gottesman MM, Bauer B, Thomas CJ, Ambudkar SV. Synthesis and characterization of a BODIPY conjugate of the BCR-ABL kinase inhibitor Tasigna (nilotinib): evidence for transport of Tasigna and its fluorescent derivative by ABC drug transporters. Molecular Pharmaceutics. 8: 1292-302. PMID 21630681 DOI: 10.1021/Mp2001022  0.444
2011 Macadangdang B, Zhang N, Lund PE, Marple AH, Okabe M, Gottesman MM, Appella DH, Kimchi-Sarfaty C. Inhibition of multidrug resistance by SV40 pseudovirion delivery of an antigene peptide nucleic acid (PNA) in cultured cells. Plos One. 6: e17981. PMID 21445346 DOI: 10.1371/Journal.Pone.0017981  0.426
2011 Kannan P, Brimacombe KR, Kreisl WC, Liow JS, Zoghbi SS, Telu S, Zhang Y, Pike VW, Halldin C, Gottesman MM, Innis RB, Hall MD. Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET. Proceedings of the National Academy of Sciences of the United States of America. 108: 2593-8. PMID 21262843 DOI: 10.1073/Pnas.1014641108  0.335
2011 Gillet JP, Gottesman MM. Advances in the molecular detection of ABC transporters involved in multidrug resistance in cancer. Current Pharmaceutical Biotechnology. 12: 686-92. PMID 21118086 DOI: 10.2174/138920111795163931  0.425
2011 Chakraborty AR, Robey RW, Collie N, Gillet J, Piekarz RL, Gottesman MM, Bates SE. Abstract 2624: Elevated expression of phosphorylated mitogen activated protein kinase kinase (MEK) as a mechanism of resistance to the histone deacetylase inhibitor romidepsin in HUT 78 cutaneous T-cell lymphoma cells Cancer Research. 71: 2624-2624. DOI: 10.1158/1538-7445.Am2011-2624  0.46
2010 Calcagno AM, Salcido CD, Gillet JP, Wu CP, Fostel JM, Mumau MD, Gottesman MM, Varticovski L, Ambudkar SV. Prolonged drug selection of breast cancer cells and enrichment of cancer stem cell characteristics. Journal of the National Cancer Institute. 102: 1637-52. PMID 20935265 DOI: 10.1093/Jnci/Djq361  0.388
2010 Shen DW, Ma J, Okabe M, Zhang G, Xia D, Gottesman MM. Elevated expression of TMEM205, a hypothetical membrane protein, is associated with cisplatin resistance. Journal of Cellular Physiology. 225: 822-8. PMID 20589834 DOI: 10.1002/Jcp.22287  0.493
2010 Liang XJ, Meng H, Wang Y, He H, Meng J, Lu J, Wang PC, Zhao Y, Gao X, Sun B, Chen C, Xing G, Shen D, Gottesman MM, Wu Y, et al. Metallofullerene nanoparticles circumvent tumor resistance to cisplatin by reactivating endocytosis. Proceedings of the National Academy of Sciences of the United States of America. 107: 7449-54. PMID 20368438 DOI: 10.1073/Pnas.0909707107  0.392
2010 Kannan P, Brimacombe KR, Zoghbi SS, Liow JS, Morse C, Taku AK, Pike VW, Halldin C, Innis RB, Gottesman MM, Hall MD. N-desmethyl-loperamide is selective for P-glycoprotein among three ATP-binding cassette transporters at the blood-brain barrier. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 38: 917-22. PMID 20212014 DOI: 10.1124/Dmd.109.031161  0.406
2010 Gillet JP, Gottesman MM. Mechanisms of multidrug resistance in cancer. Methods in Molecular Biology (Clifton, N.J.). 596: 47-76. PMID 19949920 DOI: 10.1007/978-1-60761-416-6_4  0.45
2010 Patel C, Gillet J, Stenke L, Lindberg M, Bjorkholm M, Sjoberg J, Viktorsson K, Lewensohn R, Landgren O, Gottesman MM. Individualized Multidrug Resistance In Acute Myeloid Leukemia Blood. 116: 2491-2491. DOI: 10.1182/Blood.V116.21.2491.2491  0.421
2010 Gillet J, Calcagno AM, Varma S, Davidson B, Elstrand MB, Ganapathi R, Sood AK, Ambudkar SV, Seiden MV, Rueda BR, Gottesman MM. Abstract LB-51: Correlation of expression of MDR-associated genes with outcome in primary ovarian serous carcinoma Cancer Research. 70. DOI: 10.1158/1538-7445.Am10-Lb-51  0.357
2010 Calcagno AM, Salcido CD, Gillet J, Wu C, Fostel JM, Mumau M, Gottesman MM, Varticovski L, Ambudkar SV. Abstract LB-261: Cancer stem cell characteristics exhibited by doxorubicin-selected drug-resistant breast cancer cells Cancer Research. 70. DOI: 10.1158/1538-7445.Am10-Lb-261  0.386
2010 Hall MD, Handley MD, Pluchino K, Brimacombe KR, Gottesman MM. Abstract 3533: Resistance is useless: Development of the MDR1-selective agent NSC73306 Cancer Research. 70: 3533-3533. DOI: 10.1158/1538-7445.Am10-3533  0.455
2009 Gillet JP, Gottesman MM. Identification of gene signatures involved in the mechanisms of multidrug resistance. Personalized Medicine. 6: 133-134. PMID 29788600 DOI: 10.2217/17410541.6.2.133  0.397
2009 Türk D, Hall MD, Chu BF, Ludwig JA, Fales HM, Gottesman MM, Szakács G. Identification of compounds selectively killing multidrug-resistant cancer cells. Cancer Research. 69: 8293-301. PMID 19843850 DOI: 10.1158/0008-5472.Can-09-2422  0.431
2009 Hall MD, Handley MD, Gottesman MM. Is resistance useless? Multidrug resistance and collateral sensitivity. Trends in Pharmacological Sciences. 30: 546-56. PMID 19762091 DOI: 10.1016/J.Tips.2009.07.003  0.468
2009 Chen KG, Valencia JC, Gillet JP, Hearing VJ, Gottesman MM. Involvement of ABC transporters in melanogenesis and the development of multidrug resistance of melanoma. Pigment Cell & Melanoma Research. 22: 740-9. PMID 19725928 DOI: 10.1111/J.1755-148X.2009.00630.X  0.714
2009 Chen KG, Leapman RD, Zhang G, Lai B, Valencia JC, Cardarelli CO, Vieira WD, Hearing VJ, Gottesman MM. Influence of melanosome dynamics on melanoma drug sensitivity. Journal of the National Cancer Institute. 101: 1259-71. PMID 19704071 DOI: 10.1093/Jnci/Djp259  0.68
2009 Kannan P, John C, Zoghbi SS, Halldin C, Gottesman MM, Innis RB, Hall MD. Imaging the function of P-glycoprotein with radiotracers: pharmacokinetics and in vivo applications. Clinical Pharmacology and Therapeutics. 86: 368-77. PMID 19625998 DOI: 10.1038/Clpt.2009.138  0.331
2009 Orina JN, Calcagno AM, Wu CP, Varma S, Shih J, Lin M, Eichler G, Weinstein JN, Pommier Y, Ambudkar SV, Gottesman MM, Gillet JP. Evaluation of current methods used to analyze the expression profiles of ATP-binding cassette transporters yields an improved drug-discovery database. Molecular Cancer Therapeutics. 8: 2057-66. PMID 19584229 DOI: 10.1158/1535-7163.Mct-09-0256  0.466
2009 Brimacombe KR, Hall MD, Auld DS, Inglese J, Austin CP, Gottesman MM, Fung KL. A dual-fluorescence high-throughput cell line system for probing multidrug resistance. Assay and Drug Development Technologies. 7: 233-49. PMID 19548831 DOI: 10.1089/Adt.2008.165  0.431
2009 Gottesman MM, Ambudkar SV, Xia D. Structure of a multidrug transporter. Nature Biotechnology. 27: 546-7. PMID 19513059 DOI: 10.1038/Nbt0609-546  0.328
2009 Hall MD, Salam NK, Hellawell JL, Fales HM, Kensler CB, Ludwig JA, Szakács G, Hibbs DE, Gottesman MM. Synthesis, activity, and pharmacophore development for isatin-beta-thiosemicarbazones with selective activity toward multidrug-resistant cells. Journal of Medicinal Chemistry. 52: 3191-204. PMID 19397322 DOI: 10.1021/Jm800861C  0.399
2009 Fung KL, Gottesman MM. A synonymous polymorphism in a common MDR1 (ABCB1) haplotype shapes protein function. Biochimica Et Biophysica Acta. 1794: 860-71. PMID 19285158 DOI: 10.1016/J.Bbapap.2009.02.014  0.379
2008 Okabe M, Szakács G, Reimers MA, Suzuki T, Hall MD, Abe T, Weinstein JN, Gottesman MM. Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters. Molecular Cancer Therapeutics. 7: 3081-91. PMID 18790787 DOI: 10.1158/1535-7163.Mct-08-0539  0.441
2008 Liang XJ, Finkel T, Shen DW, Yin JJ, Aszalos A, Gottesman MM. SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolism. Molecular Cancer Research : McR. 6: 1499-506. PMID 18723829 DOI: 10.1158/1541-7786.Mcr-07-2130  0.463
2008 Liang XJ, Yin JJ, Taylor B, Winkovitch SM, Garfield SH, Shen DW, Gottesman MM, Aszalos A. Disruption of microfilaments by cytochalasin B decreases accumulation of cisplatin in human epidermal carcinoma and liver carcinoma cell lines. Cancer Chemotherapy and Pharmacology. 62: 977-84. PMID 18274748 DOI: 10.1007/S00280-008-0687-9  0.473
2008 Elbaz B, Alperovitch A, Gottesman MM, Kimchi-Sarfaty C, Rahamimoff H. Modulation of Na+-Ca2+ exchanger expression by immunosuppressive drugs is isoform-specific. Molecular Pharmacology. 73: 1254-63. PMID 18182482 DOI: 10.1124/Mol.107.041582  0.378
2008 Hall MD, Okabe M, Shen DW, Liang XJ, Gottesman MM. The role of cellular accumulation in determining sensitivity to platinum-based chemotherapy. Annual Review of Pharmacology and Toxicology. 48: 495-535. PMID 17937596 DOI: 10.1146/Annurev.Pharmtox.48.080907.180426  0.42
2007 Wu CP, Shukla S, Calcagno AM, Hall MD, Gottesman MM, Ambudkar SV. Evidence for dual mode of action of a thiosemicarbazone, NSC73306: a potent substrate of the multidrug resistance linked ABCG2 transporter. Molecular Cancer Therapeutics. 6: 3287-96. PMID 18089722 DOI: 10.1158/1535-7163.Mct-07-2005  0.514
2007 Sauna ZE, Kimchi-Sarfaty C, Ambudkar SV, Gottesman MM. Silent polymorphisms speak: how they affect pharmacogenomics and the treatment of cancer. Cancer Research. 67: 9609-12. PMID 17942888 DOI: 10.1158/0008-5472.Can-07-2377  0.327
2007 Paterson JK, Shukla S, Black CM, Tachiwada T, Garfield S, Wincovitch S, Ernst DN, Agadir A, Li X, Ambudkar SV, Szakacs G, Akiyama S, Gottesman MM. Human ABCB6 localizes to both the outer mitochondrial membrane and the plasma membrane. Biochemistry. 46: 9443-52. PMID 17661442 DOI: 10.1021/Bi700015M  0.337
2007 Rahamimoff H, Elbaz B, Alperovich A, Kimchi-Sarfaty C, Gottesman MM, Lichtenstein Y, Eskin-Shwartz M, Kasir J. Cyclosporin A-dependent downregulation of the Na+/Ca2+ exchanger expression. Annals of the New York Academy of Sciences. 1099: 204-14. PMID 17446460 DOI: 10.1196/Annals.1387.046  0.363
2007 Kimchi-Sarfaty C, Marple AH, Shinar S, Kimchi AM, Scavo D, Roma MI, Kim IW, Jones A, Arora M, Gribar J, Gurwitz D, Gottesman MM. Ethnicity-related polymorphisms and haplotypes in the human ABCB1 gene. Pharmacogenomics. 8: 29-39. PMID 17187507 DOI: 10.2217/14622416.8.1.29  0.325
2006 Chen KG, Valencia JC, Lai B, Zhang G, Paterson JK, Rouzaud F, Berens W, Wincovitch SM, Garfield SH, Leapman RD, Hearing VJ, Gottesman MM. Melanosomal sequestration of cytotoxic drugs contributes to the intractability of malignant melanomas. Proceedings of the National Academy of Sciences of the United States of America. 103: 9903-7. PMID 16777967 DOI: 10.1073/Pnas.0600213103  0.686
2006 Calcagno AM, Ludwig JA, Fostel JM, Gottesman MM, Ambudkar SV. Comparison of drug transporter levels in normal colon, colon cancer, and Caco-2 cells: impact on drug disposition and discovery. Molecular Pharmaceutics. 3: 87-93. PMID 16686373 DOI: 10.1021/Mp050090K  0.422
2006 Ludwig JA, Szakács G, Martin SE, Chu BF, Cardarelli C, Sauna ZE, Caplen NJ, Fales HM, Ambudkar SV, Weinstein JN, Gottesman MM. Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer. Cancer Research. 66: 4808-15. PMID 16651436 DOI: 10.1158/0008-5472.Can-05-3322  0.453
2006 Szakács G, Paterson JK, Ludwig JA, Booth-Genthe C, Gottesman MM. Targeting multidrug resistance in cancer. Nature Reviews. Drug Discovery. 5: 219-34. PMID 16518375 DOI: 10.1038/Nrd1984  0.454
2006 Kimchi-Sarfaty C, Vieira WD, Dodds D, Sherman A, Kreitman RJ, Shinar S, Gottesman MM. SV40 Pseudovirion gene delivery of a toxin to treat human adenocarcinomas in mice. Cancer Gene Therapy. 13: 648-57. PMID 16498428 DOI: 10.1038/Sj.Cgt.7700943  0.317
2006 Liang XJ, Mukherjee S, Shen DW, Maxfield FR, Gottesman MM. Endocytic recycling compartments altered in cisplatin-resistant cancer cells. Cancer Research. 66: 2346-53. PMID 16489040 DOI: 10.1158/0008-5472.Can-05-3436  0.449
2006 Gottesman MM, Ling V. The molecular basis of multidrug resistance in cancer: the early years of P-glycoprotein research. Febs Letters. 580: 998-1009. PMID 16405967 DOI: 10.1016/J.Febslet.2005.12.060  0.397
2006 Shen DW, Liang XJ, Suzuki T, Gottesman MM. Identification by functional cloning from a retroviral cDNA library of cDNAs for ribosomal protein L36 and the 10-kDa heat shock protein that confer cisplatin resistance. Molecular Pharmacology. 69: 1383-8. PMID 16394183 DOI: 10.1124/Mol.105.017525  0.4
2006 Chen KG, Gottesman MM. How melanoma cells evade chemotherapy role of transporter-dependent and -independent resistance mechanisms From Melanocytes to Melanoma: the Progression to Malignancy. 591-603. DOI: 10.1007/978-1-59259-994-3_33  0.663
2005 Kimchi-Sarfaty C, Brittain S, Garfield S, Caplen NJ, Tang Q, Gottesman MM. Efficient delivery of RNA interference effectors via in vitro-packaged SV40 pseudovirions. Human Gene Therapy. 16: 1110-5. PMID 16149909 DOI: 10.1089/Hum.2005.16.1110  0.319
2005 Bar-Sinai A, Bassa N, Fischette M, Gottesman MM, Love DC, Hanover JA, Hochman J. Mouse mammary tumor virus Env-derived peptide associates with nucleolar targets in lymphoma, mammary carcinoma, and human breast cancer. Cancer Research. 65: 7223-30. PMID 16103073 DOI: 10.1158/0008-5472.Can-04-3879  0.308
2005 Ambudkar SV, Sauna ZE, Gottesman MM, Szakacs G. A novel way to spread drug resistance in tumor cells: Functional intercellular transfer of P-glycoprotein (ABCB1) Trends in Pharmacological Sciences. 26: 385-387. PMID 15978680 DOI: 10.1016/J.Tips.2005.06.001  0.462
2005 Tarasova NI, Seth R, Tarasov SG, Kosakowska-Cholody T, Hrycyna CA, Gottesman MM, Michejda CJ. Transmembrane inhibitors of P-glycoprotein, an ABC transporter. Journal of Medicinal Chemistry. 48: 3768-75. PMID 15916428 DOI: 10.1021/Jm049065T  0.679
2005 Chen KG, Szakács G, Annereau JP, Rouzaud F, Liang XJ, Valencia JC, Nagineni CN, Hooks JJ, Hearing VJ, Gottesman MM. Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB 5beta ) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes. Pigment Cell Research / Sponsored by the European Society For Pigment Cell Research and the International Pigment Cell Society. 18: 102-12. PMID 15760339 DOI: 10.1111/J.1600-0749.2005.00214.X  0.61
2005 Chen KG, Gottesman MM. Useful tool to generate unidirectional deletion vectors by utilizing the star activity of BamHI in an NcoI-BamHI-XhoI cassette. Biotechniques. 38: 198, 200, 202, 204. PMID 15727125 DOI: 10.2144/05382Bm05  0.566
2005 Liang XJ, Shen DW, Chen KG, Wincovitch SM, Garfield SH, Gottesman MM. Trafficking and localization of platinum complexes in cisplatin-resistant cell lines monitored by fluorescence-labeled platinum. Journal of Cellular Physiology. 202: 635-41. PMID 15546142 DOI: 10.1002/Jcp.20253  0.692
2004 Pétriz J, Gottesman MM, Aran JM. An MDR-EGFP gene fusion allows for direct cellular localization, function and stability assessment of P-glycoprotein. Current Drug Delivery. 1: 43-56. PMID 16305369 DOI: 10.2174/1567201043480072  0.47
2004 Szakács G, Gottesman MM. Comparing solid tumors with cell lines: Implications for identifying drug resistance genes in cancer Molecular Interventions. 4: 323-325. PMID 15616161 DOI: 10.1124/Mi.4.6.5  0.353
2004 Kimchi-Sarfaty C, Gottesman MM. SV40 pseudovirions as highly efficient vectors for gene transfer and their potential application in cancer therapy Current Pharmaceutical Biotechnology. 5: 451-458. PMID 15544493 DOI: 10.2174/1389201043376670  0.318
2004 Liang XJ, Shen DW, Gottesman MM. A pleiotropic defect reducing drug accumulation in cisplatin-resistant cells. Journal of Inorganic Biochemistry. 98: 1599-606. PMID 15458822 DOI: 10.1016/J.Jinorgbio.2004.05.015  0.469
2004 Shen DW, Liang XJ, Gawinowicz MA, Gottesman MM. Identification of cytoskeletal [14C]carboplatin-binding proteins reveals reduced expression and disorganization of actin and filamin in cisplatin-resistant cell lines. Molecular Pharmacology. 66: 789-93. PMID 15385639 DOI: 10.1124/Mol.66.4.789  0.398
2004 Annereau JP, Szakács G, Tucker CJ, Arciello A, Cardarelli C, Collins J, Grissom S, Zeeberg BR, Reinhold W, Weinstein JN, Pommier Y, Paules RS, Gottesman MM. Analysis of ATP-binding cassette transporter expression in drug-selected cell lines by a microarray dedicated to multidrug resistance Molecular Pharmacology. 66: 1397-1405. PMID 15342794 DOI: 10.1124/Mol.104.005009  0.505
2004 Kimchi-Sarfaty C, Alexander NS, Brittain S, Ali S, Gottesman MM. Transduction of multiple cell types using improved conditions for gene delivery and expression of SV40 pseudovirions packaged in vitro. Biotechniques. 37: 270-5. PMID 15335219 DOI: 10.2144/04372Rr04  0.411
2004 Szakács G, Annereau JP, Lababidi S, Shankavaram U, Arciello A, Bussey KJ, Reinhold W, Guo Y, Kruh GD, Reimers M, Weinstein JN, Gottesman MM. Predicting drug sensitivity and resistance: Profiling ABC transporter genes in cancer cells Cancer Cell. 6: 129-137. PMID 15324696 DOI: 10.1016/J.Ccr.2004.06.026  0.479
2004 Gouazé V, Yu JY, Bleicher RJ, Han TY, Liu YY, Wang H, Gottesman MM, Bitterman A, Giuliano AE, Cabot MC. Overexpression of glucosylceramide synthase and P-glycoprotein in cancer cells selected for resistance to natural product chemotherapy. Molecular Cancer Therapeutics. 3: 633-9. PMID 15141021  0.403
2004 Liang XJ, Shen DW, Gottesman MM. Down-regulation and altered localization of gamma-catenin in cisplatin-resistant adenocarcinoma cells. Molecular Pharmacology. 65: 1217-24. PMID 15102950 DOI: 10.1124/Mol.65.5.1217  0.43
2004 Szakács G, Chen GK, Gottesman MM. The molecular mysteries underlying P-glycoprotein-mediated multidrug resistance Cancer Biology and Therapy. 3: 382-384. PMID 14976423 DOI: 10.4161/Cbt.3.4.743  0.433
2004 Liang XJ, Yin JJ, Zhou JW, Wang PC, Taylor B, Cardarelli C, Kozar M, Forte R, Aszalos A, Gottesman MM. Changes in biophysical parameters of plasma membranes influence cisplatin resistance of sensitive and resistant epidermal carcinoma cells. Experimental Cell Research. 293: 283-91. PMID 14729466 DOI: 10.1016/J.Yexcr.2003.10.012  0.427
2003 Lee JK, Bussey KJ, Gwadry FG, Reinhold W, Riddick G, Pelletier SL, Nishizuka S, Szakacs G, Annereau JP, Shankavaram U, Lababidi S, Smith LH, Gottesman MM, Weinstein JN. Comparing cDNA and oligonucleotide array data: concordance of gene expression across platforms for the NCI-60 cancer cells Genome Biology. 4: R82. PMID 14659019 DOI: 10.1186/Gb-2003-4-12-R82  0.326
2003 Ambudkar SV, Kimchi-Sarfaty C, Sauna ZE, Gottesman MM. P-glycoprotein: From genomics to mechanism Oncogene. 22: 7468-7485. PMID 14576852 DOI: 10.1038/Sj.Onc.1206948  0.429
2003 Liang XJ, Shen DW, Garfield S, Gottesman MM. Mislocalization of membrane proteins associated with multidrug resistance in cisplatin-resistant cancer cell lines. Cancer Research. 63: 5909-16. PMID 14522917  0.33
2003 Alemán C, Annereau JP, Liang XJ, Cardarelli CO, Taylor B, Yin JJ, Aszalos A, Gottesman MM. P-glycoprotein, expressed in multidrug resistant cells, is not responsible for alterations in membrane fluidity or membrane potential. Cancer Research. 63: 3084-91. PMID 12810633  0.319
2003 Ying YL, Shen DW, Liang XJ, Gottesman MM. Codominance of cisplatin resistance in somatic cell hybrids. Journal of Cellular Physiology. 196: 63-9. PMID 12767041 DOI: 10.1002/Jcp.10320  0.45
2003 Sugimoto Y, Tsukahara S, Sato S, Suzuki M, Nunoi H, Malech HL, Gottesman MM, Tsuruo T. Drug-selected co-expression of P-glycoprotein and gp91 in vivo from an MDR1-bicistronic retrovirus vector Ha-MDR-IRES-gp91. The Journal of Gene Medicine. 5: 366-76. PMID 12731085 DOI: 10.1002/Jgm.362  0.441
2003 Chauhan SS, Liang XJ, Su AW, Pai-Panandiker A, Shen DW, Hanover JA, Gottesman MM. Reduced endocytosis and altered lysosome function in cisplatin-resistant cell lines. British Journal of Cancer. 88: 1327-34. PMID 12698203 DOI: 10.1038/Sj.Bjc.6600861  0.423
2003 Stein WD, Robey R, Cardarelli C, Gottesman MM, Bates SE. Low and high concentrations of the topo II inhibitor daunorubicin in NIH3T3 cells: reversible G2/M versus irreversible G1 and S arrest. Cell Cycle (Georgetown, Tex.). 2: 134-42. PMID 12695665 DOI: 10.4161/Cc.2.2.294  0.39
2003 Kimchi-Sarfaty C, Arora M, Sandalon Z, Oppenheim A, Gottesman MM. High cloning capacity of in vitro packaged SV40 vectors with no SV40 virus sequences Human Gene Therapy. 14: 167-177. PMID 12614568 DOI: 10.1089/104303403321070865  0.384
2002 Kimchi-Sarfaty C, Gribar JJ, Gottesman MM. Functional characterization of coding polymorphisms in the human MDR1 gene using a vaccinia virus expression system Molecular Pharmacology. 62: 1-6. PMID 12065748 DOI: 10.1124/Mol.62.1.1  0.383
2002 Gottesman MM, Fojo T, Bates SE. Multidrug resistance in cancer: role of ATP-dependent transporters. Nature Reviews. Cancer. 2: 48-58. PMID 11902585 DOI: 10.1038/nrc706  0.364
2002 Licht T, Haskins M, Henthorn P, Kleiman SE, Bodine DM, Whitwam T, Puck JM, Gottesman MM, Melniczek JR. Drug selection with paclitaxel restores expression of linked IL-2 receptor gamma -chain and multidrug resistance (MDR1) transgenes in canine bone marrow. Proceedings of the National Academy of Sciences of the United States of America. 99: 3123-8. PMID 11867757 DOI: 10.1073/Pnas.052712199  0.353
2002 Gottesman MM. Mechanisms of cancer drug resistance Annual Review of Medicine. 53: 615-627. PMID 11818492 DOI: 10.1146/Annurev.Med.53.082901.103929  0.441
2002 Kimchi-Sarfaty C, Ben-Nun-Shaul O, Rund D, Oppenheim A, Gottesman MM. In vitro-packaged SV40 pseudovirions as highly efficient vectors for gene transfer Human Gene Therapy. 13: 299-310. PMID 11812285 DOI: 10.1089/10430340252769815  0.453
2002 Gottesman MM, Fojo T, Bates SE. Multidrug resistance in cancer: Role of ATP-dependent transporters Nature Reviews Cancer. 2: 48-58. DOI: 10.1038/Nrc706  0.469
2001 Gottesman MM, Ambudkar SV. Overview: ABC transporters and human disease Journal of Bioenergetics and Biomembranes. 33: 453-458. PMID 11804186 DOI: 10.1023/A:1012866803188  0.362
2001 Lee CG, Vieira WD, Pastan I, Gottesman MM. An episomally maintained MDR1 gene for gene therapy. Human Gene Therapy. 12: 945-53. PMID 11387059 DOI: 10.1089/104303401750195908  0.456
2001 Sedelnikova OA, Panyutin IG, Luu AN, Reed MW, Licht T, Gottesman MM, Neumann RD. Targeting the human mdr1 gene by 125I-labeled triplex-forming oligonucleotides. Antisense & Nucleic Acid Drug Development. 10: 443-52. PMID 11198928 DOI: 10.1089/Oli.1.2000.10.443  0.36
2000 Ambudkar SV, Rosen BP, Gottesman MM. Workshop on ABC Transporters and Human Diseases. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 3: 51-54. PMID 11498366 DOI: 10.1054/Drup.2000.0125  0.338
2000 Booth CL, Pulaski L, Gottesman MM, Pastan I. Analysis of the properties of the N-terminal nucleotide-binding domain of human P-glycoprotein. Biochemistry. 39: 5518-26. PMID 10820025 DOI: 10.1021/Bi992931X  0.326
2000 Hafkemeyer P, Licht T, Pastan I, Gottesman MM. Chemoprotection of hematopoietic cells by a mutant P-glycoprotein resistant to a potent chemosensitizer of multidrug-resistant cancers. Human Gene Therapy. 11: 555-65. PMID 10724034 DOI: 10.1089/10430340050015743  0.465
2000 Shen DW, Goldenberg S, Pastan I, Gottesman MM. Decreased accumulation of [14C]carboplatin in human cisplatin-resistant cells results from reduced energy-dependent uptake. Journal of Cellular Physiology. 183: 108-16. PMID 10699972 DOI: 10.1002/(Sici)1097-4652(200004)183:1<108::Aid-Jcp13>3.0.Co;2-4  0.499
2000 Lee CG, Ramachandra M, Jeang KT, Martin MA, Pastan I, Gottesman MM. Effect of ABC transporters on HIV-1 infection: inhibition of virus production by the MDR1 transporter. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 14: 516-22. PMID 10698967 DOI: 10.1096/Fasebj.14.3.516  0.315
2000 Licht T, Goldenberg SK, Vieira WD, Gottesman MM, Pastan I. Drug selection of MDR1-transduced hematopoietic cells ex vivo increases transgene expression and chemoresistance in reconstituted bone marrow in mice. Gene Therapy. 7: 348-58. PMID 10694816 DOI: 10.1038/Sj.Gt.3301087  0.422
2000 Shen D, Goldenberg S, Pastan I, Gottesman MM. Decreased accumulation of [14c]carboplatin in human cisplatin-resistant cells results from reduced energy-dependent uptakeThis article is a US Government work and, as such, is in the public domain in the United States of America. Journal of Cellular Physiology. 183: 108. DOI: 10.1002/(Sici)1097-4652(200004)183:1<108::Aid-Jcp13>3.3.Co;2-W  0.337
1999 Zhou Y, Gottesman MM, Pastan I. Domain exchangeability between the multidrug transporter (MDR1) and phosphatidylcholine flippase (MDR2). Molecular Pharmacology. 56: 997-1004. PMID 10531406 DOI: 10.1124/Mol.56.5.997  0.442
1999 Hrycyna CA, Ramachandra M, Germann UA, Cheng PW, Pastan I, Gottesman MM. Both ATP sites of human P-glycoprotein are essential but not symmetric. Biochemistry. 38: 13887-99. PMID 10529234 DOI: 10.1021/Bi991115M  0.648
1999 Licht T, Aran JM, Goldenberg SK, Vieira WD, Gottesman MM, Pastan I. Retroviral transfer of human MDR1 gene to hematopoietic cells: effects of drug selection and of transcript splicing on expression of encoded P-glycoprotein. Human Gene Therapy. 10: 2173-85. PMID 10498249 DOI: 10.1089/10430349950017167  0.441
1999 Zhou Y, Gottesman MM, Pastan I. The extracellular loop between TM5 and TM6 of P-glycoprotein is required for reactivity with monoclonal antibody UIC2. Archives of Biochemistry and Biophysics. 367: 74-80. PMID 10375401 DOI: 10.1006/Abbi.1999.1221  0.37
1999 Dey S, Hafkemeyer P, Pastan I, Gottesman MM. A single amino acid residue contributes to distinct mechanisms of inhibition of the human multidrug transporter by stereoisomers of the dopamine receptor antagonist flupentixol. Biochemistry. 38: 6630-9. PMID 10350482 DOI: 10.1021/Bi983038L  0.384
1999 Aran JM, Pastan I, Gottesman MM. Therapeutic strategies involving the multidrug resistance phenotype: the MDR1 gene as target, chemoprotectant, and selectable marker in gene therapy. Advances in Pharmacology (San Diego, Calif.). 46: 1-42. PMID 10332500 DOI: 10.1016/S1054-3589(08)60468-8  0.371
1999 Ambudkar SV, Dey S, Hrycyna CA, Ramachandra M, Pastan I, Gottesman MM. Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annual Review of Pharmacology and Toxicology. 39: 361-98. PMID 10331089 DOI: 10.1146/Annurev.Pharmtox.39.1.361  0.691
1999 Hafkemeyer P, Brinkmann U, Gottesman MM, Pastan I. Apoptosis induced by Pseudomonas exotoxin: a sensitive and rapid marker for gene delivery in vivo. Human Gene Therapy. 10: 923-34. PMID 10223726 DOI: 10.1089/10430349950018328  0.333
1999 Zhou Y, Gottesman MM, Pastan I. Studies of human MDR1-MDR2 chimeras demonstrate the functional exchangeability of a major transmembrane segment of the multidrug transporter and phosphatidylcholine flippase. Molecular and Cellular Biology. 19: 1450-9. PMID 9891078 DOI: 10.1128/Mcb.19.2.1450  0.415
1999 Moscow JA, Huang H, Carter C, Hines K, Zujewski J, Cusack G, Chow C, Venzon D, Sorrentino B, Chiang Y, Goldspiel B, Leitman S, Read EJ, Abati A, Gottesman MM, et al. Engraftment of MDR1 and NeoR Gene-Transduced Hematopoietic Cells After Breast Cancer Chemotherapy Blood. 94: 52-61. DOI: 10.1182/Blood.V94.1.52.413K35_52_61  0.399
1998 Hrycyna CA, Gottesman MM. Multidrug ABC transporters from bacteria to man: an emerging hypothesis for the universality of molecular mechanism and function. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 1: 81-3. PMID 16904390 DOI: 10.1016/S1368-7646(98)80019-8  0.676
1998 Hafkemeyer P, Dey S, Ambudkar SV, Hrycyna CA, Pastan I, Gottesman MM. Contribution to substrate specificity and transport of nonconserved residues in transmembrane domain 12 of human P-glycoprotein. Biochemistry. 37: 16400-9. PMID 9819232 DOI: 10.1021/bi980871  0.683
1998 Russ G, Ramachandra M, Hrycyna CA, Gottesman MM, Pastan I, Bennink JR, Yewdell JW. P-glycoprotein plays an insignificant role in the presentation of antigenic peptides to CD8+ T cells. Cancer Research. 58: 4688-93. PMID 9788623  0.636
1998 Hrycyna CA, Airan LE, Germann UA, Ambudkar SV, Pastan I, Gottesman MM. Structural flexibility of the linker region of human P-glycoprotein permits ATP hydrolysis and drug transport. Biochemistry. 37: 13660-73. PMID 9753453 DOI: 10.1021/Bi9808823  0.7
1998 Lee CG, Pastan I, Gottesman MM. Retroviral transfer of human MDR1 gene into human T lymphocytes. Methods in Enzymology. 292: 557-72. PMID 9711583 DOI: 10.1016/S0076-6879(98)92044-4  0.441
1998 Licht T, Gottesman MM, Pastan I. Retroviral transfer of multidrug transporter to murine hematopoietic stem cells. Methods in Enzymology. 292: 546-57. PMID 9711582 DOI: 10.1016/S0076-6879(98)92043-2  0.412
1998 Hrycyna CA, Ramachandra M, Pastan I, Gottesman MM. Functional expression of human P-glycoprotein from plasmids using vaccinia virus-bacteriophage T7 RNA polymerase system. Methods in Enzymology. 292: 456-73. PMID 9711574 DOI: 10.1016/S0076-6879(98)92035-3  0.692
1998 Dey S, Ramachandra M, Pastan I, Gottesman MM, Ambudkar SV. Photoaffinity labeling of human P-glycoprotein: effect of modulator interaction and ATP hydrolysis on substrate binding. Methods in Enzymology. 292: 318-28. PMID 9711564 DOI: 10.1016/S0076-6879(98)92025-0  0.375
1998 Gottesman MM, Cardarelli C, Goldenberg S, Licht T, Pastan I. Selection and maintenance of multidrug-resistant cells. Methods in Enzymology. 292: 248-58. PMID 9711558 DOI: 10.1016/S0076-6879(98)92019-5  0.347
1998 Hrycyna CA, Ramachandra M, Ambudkar SV, Ko YH, Pedersen PL, Pastan I, Gottesman MM. Mechanism of action of human P-glycoprotein ATPase activity. Photochemical cleavage during a catalytic transition state using orthovanadate reveals cross-talk between the two ATP sites. The Journal of Biological Chemistry. 273: 16631-4. PMID 9642211 DOI: 10.1074/Jbc.273.27.16631  0.608
1998 Rund D, Dagan M, Dalyot-Herman N, Kimchi-Sarfaty C, Schoenlein PV, Gottesman MM, Oppenheim A. Efficient transduction of human hematopoietic cells with the human multidrug resistance gene 1 via SV40 pseudovirions. Human Gene Therapy. 9: 649-57. PMID 9551613 DOI: 10.1089/Hum.1998.9.5-649  0.462
1998 Ramachandra M, Ambudkar SV, Chen D, Hrycyna CA, Dey S, Gottesman MM, Pastan I. Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state. Biochemistry. 37: 5010-9. PMID 9538020 DOI: 10.1021/Bi973045U  0.661
1998 Lee CG, Gottesman MM, Cardarelli CO, Ramachandra M, Jeang KT, Ambudkar SV, Pastan I, Dey S. HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter. Biochemistry. 37: 3594-601. PMID 9530286 DOI: 10.1021/Bi972709X  0.367
1998 Zhou Y, Aran J, Gottesman MM, Pastan I. Co-expression of human adenosine deaminase and multidrug resistance using a bicistronic retroviral vector. Human Gene Therapy. 9: 287-93. PMID 9508046 DOI: 10.1089/Hum.1998.9.3-287  0.414
1998 Lee CGL, Gottesman MM, Cardarelli CO, Ramachandra M, Jeang KT, Ambudkar SV, Pastan I, Dey S, Kim AE, Dintaman JM, Waddell DS, Silverman JA, Duran G, Man M, Sikic B, et al. HIV-1 protease inhibitors and the MDR1 multidrug transporter Journal of Clinical Investigation. 101: 287-288. PMID 9435298 DOI: 10.1172/JCI2575  0.463
1997 Jhappan C, Morse HC, Fleischmann RD, Gottesman MM, Merlino G. DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus. Nature Genetics. 17: 483-6. PMID 9398856 DOI: 10.1038/Ng1297-483  0.305
1997 Dey S, Ramachandra M, Pastan I, Gottesman MM, Ambudkar SV. Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein. Proceedings of the National Academy of Sciences of the United States of America. 94: 10594-9. PMID 9380680 DOI: 10.1073/Pnas.94.20.10594  0.334
1997 Lee CG, Jeang KT, Martin MA, Pastan I, Gottesman MM. Efficient long-term coexpression of a hammerhead ribozyme targeted to the U5 region of HIV-1 LTR by linkage to the multidrug-resistance gene. Antisense & Nucleic Acid Drug Development. 7: 511-22. PMID 9361910 DOI: 10.1089/Oli.1.1997.7.511  0.429
1997 Licht T, Herrmann F, Gottesman MM, Pastan I. In vivo drug-selectable genes: a new concept in gene therapy. Stem Cells (Dayton, Ohio). 15: 104-11. PMID 9090786 DOI: 10.1002/Stem.150104  0.419
1997 Gottesman MM, Pastan I, Ambudkar SV. P-glycoprotein and multidrug resistance. Current Opinion in Genetics & Development. 6: 610-7. PMID 8939727 DOI: 10.1016/S0959-437X(96)80091-8  0.481
1997 Aran JM, Licht T, Gottesman MM, Pastan I. Complete restoration of glucocerebrosidase deficiency in Gaucher fibroblasts using a bicistronic MDR retrovirus and a new selection strategy. Human Gene Therapy. 7: 2165-75. PMID 8934230 DOI: 10.1089/Hum.1996.7.17-2165  0.415
1996 Weaver JL, McKinney L, Schoenlein PV, Goldenberg S, Gottesman MM, Aszalos A. MDR1/P-glycoprotein function. I. Effect of hypotonicity and inhibitors on rhodamine 123 exclusion. The American Journal of Physiology. 270: C1447-52. PMID 8967446 DOI: 10.1152/ajpcell.1996.270.5.C1447  0.314
1996 Ramachandra M, Ambudkar SV, Gottesman MM, Pastan I, Hrycyna CA. Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system. Molecular Biology of the Cell. 7: 1485-98. PMID 8898356 DOI: 10.1091/Mbc.7.10.1485  0.667
1996 Baudard M, Flotte TR, Aran JM, Thierry AR, Pastan I, Pang MG, Kearns WG, Gottesman MM. Expression of the human multidrug resistance and glucocerebrosidase cDNAs from adeno-associated vectors: efficient promoter activity of AAV sequences and in vivo delivery via liposomes. Human Gene Therapy. 7: 1309-22. PMID 8818718 DOI: 10.1089/Hum.1996.7.11-1309  0.447
1996 Aksentijevich I, Pastan I, Lunardi-Iskandar Y, Gallo RC, Gottesman MM, Thierry AR. In vitro and in vivo liposome-mediated gene transfer leads to human MDR1 expression in mouse bone marrow progenitor cells. Human Gene Therapy. 7: 1111-22. PMID 8773513 DOI: 10.1089/Hum.1996.7.9-1111  0.402
1996 Johnson SW, Shen DW, Pastan I, Gottesman MM, Hamilton TC. Cross-resistance, cisplatin accumulation, and platinum-DNA adduct formation and removal in cisplatin-sensitive and -resistant human hepatoma cell lines Experimental Cell Research. 226: 133-139. PMID 8660948 DOI: 10.1006/Excr.1996.0211  0.455
1996 Licht T, Pastan I, Gottesman MM, Herrmann F. The multidrug-resistance gene in gene therapy of cancer and hematopoietic disorders. Annals of Hematology. 72: 184-93. PMID 8624371 DOI: 10.1007/S002770050159  0.435
1996 Campain JA, Slovak ML, Schoenlein PV, Popescu NC, Gottesman MM, Pastan I. Acquisition of multiple copies of a mutant topoisomerase IIalpha allele by chromosome 17 aneuploidy is associated with etoposide resistance in human melanoma cell lines. Somatic Cell and Molecular Genetics. 21: 451-71. PMID 8600572 DOI: 10.1007/Bf02310211  0.392
1996 Germann UA, Chambers TC, Ambudkar SV, Licht T, Cardarelli CO, Pastan I, Gottesman MM. Characterization of phosphorylation-defective mutants of human P-glycoprotein expressed in mammalian cells. The Journal of Biological Chemistry. 271: 1708-16. PMID 8576173 DOI: 10.1074/Jbc.271.3.1708  0.42
1996 Müller M, Bakos E, Welker E, Váradi A, Germann UA, Gottesman MM, Morse BS, Roninson IB, Sarkadi B. Altered drug-stimulated ATPase activity in mutants of the human multidrug resistance protein. The Journal of Biological Chemistry. 271: 1877-83. PMID 8567633 DOI: 10.1074/Jbc.271.4.1877  0.455
1996 Leonessa F, Green D, Licht T, Wright A, Wingate-Legette K, Lippman J, Gottesman MM, Clarke R. MDA435/LCC6 and MDA435/LCC6MDR1: Ascites models of human breast cancer British Journal of Cancer. 73: 154-161. PMID 8546900 DOI: 10.1038/Bjc.1996.29  0.429
1996 Sokolic R, Sekhsaria S, Sugimoto Y, Whiting-Theobald N, Linton G, Li F, Gottesman M, Malech H. A bicistronic retrovirus vector containing a picornavirus internal ribosome entry site allows for correction of X-linked CGD by selection for MDR1 expression Blood. 87: 42-50. DOI: 10.1182/Blood.V87.1.42.42  0.404
1995 Sugimoto Y, Hrycyna CA, Aksentijevich I, Pastan I, Gottesman MM. Coexpression of a multidrug-resistance gene (MDR1) and herpes simplex virus thymidine kinase gene as part of a bicistronic messenger RNA in a retrovirus vector allows selective killing of MDR1-transduced cells Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 1: 447-57. PMID 9816003  0.665
1995 Gottesman MM, Hrycyna CA, Schoenlein PV, Germann UA, Pastan I. Genetic analysis of the multidrug transporter. Annual Review of Genetics. 29: 607-49. PMID 8825488 DOI: 10.1146/Annurev.Ge.29.120195.003135  0.697
1995 Galski H, Lazarovici P, Gottesman MM, Murakata C, Matsuda Y, Hochman J. KT-5720 reverses multidrug resistance in variant S49 mouse lymphoma cells transduced with the human MDR1 cDNA and in human multidrug-resistant carcinoma cells. European Journal of Cancer (Oxford, England : 1990). 380-8. PMID 7786606 DOI: 10.1016/0959-8049(94)00511-3  0.365
1995 Campain JA, Gottesman MM, Pastan I. A novel mutant topoisomerase II alpha present in VP-16-resistant human melanoma cell lines has a deletion of alanine 429. Biochemistry. 33: 11327-32. PMID 7727383 DOI: 10.1021/Bi00203A030  0.433
1995 Shen DW, Akiyama S, Schoenlein P, Pastan I, Gottesman MM. Characterisation of high-level cisplatin-resistant cell lines established from a human hepatoma cell line and human KB adenocarcinoma cells: cross-resistance and protein changes. British Journal of Cancer. 71: 676-83. PMID 7710928 DOI: 10.1038/Bjc.1995.134  0.47
1995 Gottesman MM, Mickisch GH, Pastan I. In vivo models of P-glycoprotein-mediated multidrug resistance. Cancer Treatment and Research. 73: 107-28. PMID 7710902 DOI: 10.1007/978-1-4615-2632-2_6  0.46
1995 Germann UA, Chambers TC, Ambudkar SV, Pastan I, Gottesman MM. Effects of phosphorylation of P-glycoprotein on multidrug resistance. Journal of Bioenergetics and Biomembranes. 27: 53-61. PMID 7629052 DOI: 10.1007/Bf02110331  0.417
1995 Evans GL, Ni B, Hrycyna CA, Chen D, Ambudkar SV, Pastan I, Germann UA, Gottesman MM. Heterologous expression systems for P-glycoprotein: E. coli, yeast, and baculovirus. Journal of Bioenergetics and Biomembranes. 27: 43-52. PMID 7629051 DOI: 10.1007/Bf02110330  0.715
1995 Gottesman MM, Ambudkar SV, Ni B, Aran JM, Sugimoto Y, Cardarelli CO, Pastan I. Exploiting multidrug resistance to treat cancer. Cold Spring Harbor Symposia On Quantitative Biology. 59: 677-83. PMID 7587130 DOI: 10.1101/Sqb.1994.059.01.078  0.387
1995 Sugimoto Y, Aksentijevich I, Murray GJ, Brady RO, Pastan I, Gottesman MM. Retroviral coexpression of a multidrug resistance gene (MDR1) and human alpha-galactosidase A for gene therapy of Fabry disease. Human Gene Therapy. 6: 905-15. PMID 7578409 DOI: 10.1089/Hum.1995.6.7-905  0.356
1995 Chambers TC, Germann UA, Gottesman MM, Pastan I, Kuo JF, Ambudkar SV. Bacterial expression of the linker region of human MDR1 P-glycoprotein and mutational analysis of phosphorylation sites. Biochemistry. 34: 14156-62. PMID 7578013 DOI: 10.1021/Bi00043A021  0.338
1995 Aszalos A, Pine PS, Pandey R, Gottesman MM. Behavior of N-acylated daunorubicins in MDR1 gene transfected and parental cells. Biochemical Pharmacology. 50: 889-92. PMID 7575653 DOI: 10.1016/0006-2952(95)00209-I  0.369
1995 Gottesman MM, Hrycyna CA, Schoenlein PV, Germann UA, Pastan I. Genetic analysis of the murtidrug transporter Annual Review of Genetics. 29. DOI: 10.1146/Annurev.Genet.29.1.607  0.609
1994 Licht T, Pastan I, Gottesman M, Herrmann F. P-glycoprotein-mediated multidrug resistance in normal and neoplastic hematopoietic cells. Annals of Hematology. 69: 159-71. PMID 7948302 DOI: 10.1007/Bf02215949  0.445
1994 Gottesman MM. Report of a meeting: molecular basis of cancer therapy. Journal of the National Cancer Institute. 86: 1277-85. PMID 7914937 DOI: 10.1093/Jnci/86.17.1277  0.38
1994 Sarkadi B, Müller M, Homolya L, Holló Z, Seprödi J, Germann UA, Gottesman MM, Price EM, Boucher RC. Interaction of bioactive hydrophobic peptides with the human multidrug transporter. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 8: 766-70. PMID 7914178 DOI: 10.1096/Fasebj.8.10.7914178  0.417
1994 Lelong IH, Cardarelli CO, Gottesman MM, Pastan I. GTP-stimulated phosphorylation of P-glycoprotein in transporting vesicles from KB-V1 multidrug resistant cells. Biochemistry. 33: 8921-9. PMID 7913830 DOI: 10.1021/Bi00196A009  0.352
1994 Gottesman MM, Germann UA, Aksentijevich I, Sugimoto Y, Cardarelli CO, Pastan I. Gene transfer of drug resistance genes. Implications for cancer therapy. Annals of the New York Academy of Sciences. 716: 126-38; discussion 1. PMID 7912913 DOI: 10.1111/J.1749-6632.1994.Tb21708.X  0.435
1994 Aran JM, Gottesman MM, Pastan I. Drug-selected coexpression of human glucocerebrosidase and P-glycoprotein using a bicistronic vector. Proceedings of the National Academy of Sciences of the United States of America. 91: 3176-80. PMID 7909160 DOI: 10.1073/pnas.91.8.3176  0.339
1994 Park JG, Lee SK, Hong IG, Kim HS, Lim KH, Choe KJ, Kim WH, Kim YI, Tsuruo T, Gottesman MM. MDR1 gene expression: its effect on drug resistance to doxorubicin in human hepatocellular carcinoma cell lines. Journal of the National Cancer Institute. 86: 700-5. PMID 7908989 DOI: 10.1093/Jnci/86.9.700  0.471
1994 Siegsmund MJ, Cardarelli C, Aksentijevich I, Sugimoto Y, Pastan I, Gottesman MM. Ketoconazole effectively reverses multidrug resistance in highly resistant KB cells. The Journal of Urology. 151: 485-91. PMID 7904313 DOI: 10.1016/S0022-5347(17)34999-6  0.358
1994 Sugimoto Y, Aksentijevich I, Gottesman MM, Pastan I. Efficient expression of drug-selectable genes in retroviral vectors under control of an internal ribosome entry site. Bio/Technology (Nature Publishing Company). 12: 694-8. PMID 7764914 DOI: 10.1038/Nbt0794-694  0.378
1994 Germann UA, Schoenlein PV, Zimonjic DB, Popescu NC, Pastan I, Gottesman MM. Putative "MDR enhancer" is located on human chromosome 20 and not linked to the MDR1 gene on chromosome 7. Genes, Chromosomes & Cancer. 10: 267-74. PMID 7522541 DOI: 10.1002/Gcc.2870100408  0.338
1994 Gottesman MM, Currier S, Bruggemann E, Lelong I, Stein W, Pastan I. Chapter 1 The Multidrug Transporter: Mechanistic Considerations Current Topics in Membranes. 41: 3-17. DOI: 10.1016/S0070-2161(08)60451-7  0.452
1993 Chin KV, Pastan I, Gottesman MM. Function and regulation of the human multidrug resistance gene. Advances in Cancer Research. 60: 157-80. PMID 8417499 DOI: 10.1016/S0065-230X(08)60825-8  0.399
1993 Mickisch GH, Pai LH, Siegsmund M, Campain J, Gottesman MM, Pastan I. Pseudomonas exotoxin conjugated to monoclonal antibody MRK16 specifically kills multidrug resistant cells in cultured renal carcinomas and in MDR-transgenic mice. The Journal of Urology. 149: 174-8. PMID 8417204 DOI: 10.1016/S0022-5347(17)36033-0  0.426
1993 Gosse ME, Padmanabhan A, Fleischmann RD, Gottesman MM. Expression of Chinese hamster cAMP-dependent protein kinase in Escherichia coli results in growth inhibition of bacterial cells: a model system for the rapid screening of mutant type I regulatory subunits. Proceedings of the National Academy of Sciences of the United States of America. 90: 8159-63. PMID 8396261 DOI: 10.1073/Pnas.90.17.8159  0.328
1993 Wang N, Gottesman S, Willingham MC, Gottesman MM, Maurizi MR. A human mitochondrial ATP-dependent protease that is highly homologous to bacterial Lon protease. Proceedings of the National Academy of Sciences of the United States of America. 90: 11247-51. PMID 8248235 DOI: 10.1073/Pnas.90.23.11247  0.342
1993 Gottesman MM, Pastan I. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annual Review of Biochemistry. 62: 385-427. PMID 8102521 DOI: 10.1146/Annurev.Bi.62.070193.002125  0.427
1993 Campain JA, Padmanabhan R, Hwang J, Gottesman MM, Pastan I. Characterization of an unusual mutant of human melanoma cells resistant to anticancer drugs that inhibit topoisomerase II. Journal of Cellular Physiology. 155: 414-25. PMID 8097746 DOI: 10.1002/Jcp.1041550224  0.485
1993 Kane SE, Gottesman MM. Use of multidrug resistance gene in mammalian expression vectors. Methods in Enzymology. 217: 34-47. PMID 8097271 DOI: 10.1016/0076-6879(93)17054-9  0.438
1993 Germann UA, Pastan I, Gottesman MM. P-glycoproteins: mediators of multidrug resistance. Seminars in Cell Biology. 4: 63-76. PMID 8095827 DOI: 10.1006/scel.1993.1008  0.389
1993 Padmanabhan R, Padmanabhan R, Howard T, Gottesman MM, Howard BH. Magnetic affinity cell sorting to isolate transiently transfected cells, multidrug-resistant cells, somatic cell hybrids, and virally infected cells. Methods in Enzymology. 218: 637-51. PMID 7685471 DOI: 10.1016/0076-6879(93)18047-G  0.433
1993 Weaver JL, Szabo G, Pine PS, Gottesman MM, Goldenberg S, Aszalos A. The effect of ion channel blockers, immunosuppressive agents, and other drugs on the activity of the multi-drug transporter. International Journal of Cancer. 54: 456-61. PMID 7685326 DOI: 10.1002/Ijc.2910540317  0.388
1992 Schoenlein PV, Shen DW, Barrett JT, Pastan I, Gottesman MM. Double minute chromosomes carrying the human multidrug resistance 1 and 2 genes are generated from the dimerization of submicroscopic circular DNAs in colchicine-selected KB carcinoma cells. Molecular Biology of the Cell. 3: 507-20. PMID 1611154 DOI: 10.1091/Mbc.3.5.507  0.406
1992 Mickisch GH, Rahman A, Pastan I, Gottesman MM. Increased effectiveness of liposome-encapsulated doxorubicin in multidrug-resistant-transgenic mice compared with free doxorubicin. Journal of the National Cancer Institute. 84: 804-5. PMID 1573669 DOI: 10.1093/Jnci/84.10.804  0.343
1992 Higgins CF, Gottesman MM. Is the multidrug transporter a flippase? Trends in Biochemical Sciences. 17: 18-21. PMID 1374941 DOI: 10.1016/0968-0004(92)90419-A  0.44
1992 Clarke R, Currier S, Kaplan O, Lovelace E, Boulay V, Gottesman MM, Dickson RB. Effect of P-glycoprotein expression on sensitivity to hormones in MCF-7 human breast cancer cells. Journal of the National Cancer Institute. 84: 1506-12. PMID 1359153 DOI: 10.1093/Jnci/84.19.1506  0.395
1992 Ambudkar SV, Lelong IH, Zhang J, Cardarelli CO, Gottesman MM, Pastan I. Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis. Proceedings of the National Academy of Sciences of the United States of America. 89: 8472-6. PMID 1356264 DOI: 10.1073/pnas.89.18.8472  0.333
1992 Goldstein LJ, Pastan I, Gottesman MM. Multidrug resistance in human cancer Critical Reviews in Oncology and Hematology. 12: 243-253. PMID 1353966 DOI: 10.1016/1040-8428(92)90057-W  0.33
1992 Sorrentino BP, Brandt SJ, Bodine D, Gottesman M, Pastan I, Cline A, Nienhuis AW. Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1 Science. 257: 99-103. PMID 1352414 DOI: 10.1126/Science.1352414  0.416
1992 Chin KV, Chauhan SS, Abraham I, Sampson KE, Krolczyk AJ, Wong M, Schimmer B, Pastan I, Gottesman MM. Reduced mRNA levels for the multidrug-resistance genes in cAMP-dependent protein kinase mutant cell lines. Journal of Cellular Physiology. 152: 87-94. PMID 1352302 DOI: 10.1002/Jcp.1041520112  0.462
1992 Lelong IH, Padmanabhan R, Lovelace E, Pastan I, Gottesman MM. ATP and GTP as alternative energy sources for vinblastine transport by P-170 in KB-V1 plasma membrane vesicles. Febs Letters. 304: 256-60. PMID 1352260 DOI: 10.1016/0014-5793(92)80632-Q  0.337
1992 Fleischmann RD, Jeng C, Gottesman MM. Ablation of stimulation of a cAMP-responsive promoter in CHO cell lines defective in their cAMP-dependent protein kinase system Somatic Cell and Molecular Genetics. 18: 103-111. PMID 1349445 DOI: 10.1007/Bf01233157  0.374
1992 Chin KV, Ueda K, Pastan I, Gottesman MM. Modulation of activity of the promoter of the human MDR1 gene by Ras and p53. Science (New York, N.Y.). 255: 459-62. PMID 1346476 DOI: 10.1126/Science.1346476  0.399
1992 Chauhan SS, Gottesman MM. Construction of a new universal vector for insertional mutagenesis by homologous recombination Gene. 120: 281-285. PMID 1327975 DOI: 10.1016/0378-1119(92)90106-Y  0.391
1991 Hochman J, Park SS, Lazarovici P, Bergel M, Gottesman MM. Monoclonal antibodies to immunogenic lymphoma cell variants displaying impaired neoplastic properties: characterization and applications. Journal of the National Cancer Institute. 82: 1821-6. PMID 2250297 DOI: 10.1093/Jnci/82.23.1821  0.331
1991 Cenciarelli C, Currier SJ, Willingham MC, Thiebaut F, Germann UA, Rutherford AV, Gottesman MM, Barca S, Tombesi M, Morrone S, Santoni A, Mariani M, Ramoni C, Dupuis ML, Cianfriglia M. Characterization by somatic cell genetics of a monoclonal antibody to the MDR1 gene product (P-glycoprotein): determination of P-glycoprotein expression in multi-drug-resistant KB and CEM cell variants. International Journal of Cancer. 47: 533-43. PMID 1704872 DOI: 10.1002/ijc.2910470411  0.366
1991 Goldstein LJ, Gottesman MM, Pastan I. Expression of the MDR1 gene in human cancers Cancer Treatment and Research. 57: 101-119. PMID 1686712 DOI: 10.1007/978-1-4615-3872-1_5  0.305
1991 Mickisch GH, Pastan I, Gottesman MM. Multidrug resistant transgenic mice as a novel pharmacologic tool. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 13: 381-7. PMID 1683231 DOI: 10.1002/Bies.950130804  0.434
1991 Pearson JW, Fogler WE, Volker K, Usui N, Goldenberg SK, Gruys E, Riggs CW, Komschlies K, Wiltrout RH, Tsuruo T, Pastan I, Gottesman MM, Longo DL. Reversal of drug resistance in a human colon cancer xenograft expressing MDR1 complementary DNA by in vivo administration of MRK-16 monoclonal antibody. Journal of the National Cancer Institute. 83: 1386-1391. PMID 1681110 DOI: 10.1093/Jnci/83.19.1386  0.337
1991 Weaver JL, Pine PS, Aszalos A, Schoenlein PV, Currier SJ, Padmanabhan R, Gottesman MM. Laser scanning and confocal microscopy of daunorubicin, doxorubicin, and rhodamine 123 in multidrug-resistant cells. Experimental Cell Research. 196: 323-9. PMID 1680064 DOI: 10.1016/0014-4827(91)90267-X  0.42
1991 Salminen A, Elson HF, Mickley LA, Fojo AT, Gottesman MM. Implantation of recombinant rat myocytes into adult skeletal muscle: a potential gene therapy. Human Gene Therapy. 2: 15-26. PMID 1677815 DOI: 10.1089/Hum.1991.2.1-15  0.31
1991 Mickisch GH, Merlino GT, Aiken PM, Gottesman MM, Pastan I. New potent verapamil derivatives that reverse multidrug resistance in human renal carcinoma cells and in transgenic mice expressing the human MDR1 gene. The Journal of Urology. 146: 447-53. PMID 1677434 DOI: 10.1016/S0022-5347(17)37822-9  0.454
1991 Padmanabhan R, Tsuruo T, Kane SE, Willingham MC, Howard BH, Gottesman MM, Pastan I. Magnetic-affinity cell sorting of human multidrug-resistant cells. Journal of the National Cancer Institute. 83: 565-9. PMID 1672384 DOI: 10.1093/Jnci/83.8.565  0.474
1991 Horio M, Lovelace E, Pastan I, Gottesman MM. Agents which reverse multidrug-resistance are inhibitors of [3H]vinblastine transport by isolated vesicles. Biochimica Et Biophysica Acta. 1061: 106-10. PMID 1671642 DOI: 10.1016/0005-2736(91)90274-C  0.353
1991 Mickisch GH, Merlino GT, Galski H, Gottesman MM, Pastan I. Transgenic mice that express the human multidrug-resistance gene in bone marrow enable a rapid identification of agents that reverse drug resistance. Proceedings of the National Academy of Sciences of the United States of America. 88: 547-51. PMID 1671173 DOI: 10.1073/Pnas.88.2.547  0.455
1991 Reddy PG, Graham GM, Datta S, Guarini L, Moulton TA, Jiang HP, Gottesman MM, Ferrone S, Fisher PB. Effect of recombinant fibroblast interferon and recombinant immune interferon on growth and the antigenic phenotype of multidrug-resistant human glioblastoma multiforme cells. Journal of the National Cancer Institute. 83: 1307-15. PMID 1653364 DOI: 10.1093/Jnci/83.18.1307  0.448
1991 Mickisch G, Alken P, Gottesman M, Pastan I. Neue Verapamil-Derivate überwinden multidrug resistance im Nierenzellkarzinom und in transgenen Mäusen, die das menschliche MDR1-Gen exprimieren Aktuelle Urologie. 22: 125-131. DOI: 10.1055/S-2008-1060490  0.382
1991 Mickisch G, Merlino G, Galski H, Willingham M, Gottesman M, Pastan I. Die multidrug resistente transgene Maus: In-vivo-Charakterisierung des menschlichen MDR-1 Genes Aktuelle Urologie. 22: 85-91. DOI: 10.1055/S-2008-1060484  0.338
1991 Gottesman MM, Goldstein LJ, Fojo A, Galski H, Pastan I. Expression of the Multidrug Resistance Gene in Human Cancer Journal of the National Cancer Institute. 81: 116-124. DOI: 10.1007/978-1-4615-3794-6_15  0.417
1990 Kane SE, Reinhard DH, Fordis CM, Pastan I, Gottesman MM. A new vector using the human multidrug resistance gene as a selectable marker enables overexpression of foreign genes in eukaryotic cells. Gene. 84: 439-46. PMID 2575560 DOI: 10.1016/0378-1119(89)90518-0  0.368
1990 Ueda K, Yamano Y, Kioka N, Kakehi Y, Yoshida O, Gottesman MM, Pastan I, Komano T. Detection of multidrug resistance (MDR1) gene RNA expression in human tumors by a sensitive ribonuclease protection assay. Japanese Journal of Cancer Research : Gann. 80: 1127-32. PMID 2481665 DOI: 10.1111/j.1349-7006.1989.tb02269.x  0.303
1990 McLachlin JR, Eglitis MA, Ueda K, Kantoff PW, Pastan IH, Anderson WF, Gottesman MM. Expression of a human complementary DNA for the multidrug resistance gene in murine hematopoietic precursor cells with the use of retroviral gene transfer. Journal of the National Cancer Institute. 82: 1260-3. PMID 2374175 DOI: 10.1093/Jnci/82.15.1260  0.476
1990 Sato H, Gottesman MM, Goldstein LJ, Pastan I, Block AM, Sandberg AA, Preisler HD. Expression of the multidrug resistance gene in myeloid leukemias Leukemia Research. 14. PMID 2304354 DOI: 10.1016/0145-2126(90)90141-U  0.341
1990 Goldstein LJ, Fojo AT, Ueda K, Crist W, Green A, Brodeur G, Pastan I, Gottesman MM. Expression of the multidrug resistance, MDR1, gene in neuroblastomas Journal of Clinical Oncology. 8: 128-136. PMID 2295903 DOI: 10.1200/Jco.1990.8.1.128  0.414
1990 Dickson RB, Gottesman MM. Understanding of the molecular basis of drug resistance in cancer reveals new targets for chemotherapy. Trends in Pharmacological Sciences. 11: 305-7. PMID 2203190 DOI: 10.1016/0165-6147(90)90227-Y  0.39
1990 Kane SE, Pastan I, Gottesman MM. Genetic basis of multidrug resistance of tumor cells. Journal of Bioenergetics and Biomembranes. 22: 593-618. PMID 1977744 DOI: 10.1007/Bf00762963  0.49
1990 Abraham I, Chin KV, Gottesman MM, Mayo JK, Sampson KE. Transfection of a mutant regulatory subunit gene of cAMP-dependent protein kinase causes increased drug sensitivity and decreased expression of P-glycoprotein. Experimental Cell Research. 189: 133-41. PMID 1971796 DOI: 10.1016/0014-4827(90)90265-C  0.363
1990 Germann UA, Willingham MC, Pastan I, Gottesman MM. Expression of the human multidrug transporter in insect cells by a recombinant baculovirus. Biochemistry. 29: 2295-303. PMID 1970935 DOI: 10.1021/Bi00461A013  0.474
1990 Germann UA, Chin KV, Pastan I, Gottesman MM. Retroviral transfer of a chimeric multidrug resistance-adenosine deaminase gene. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 4: 1501-7. PMID 1968408 DOI: 10.1096/fasebj.4.5.1968408  0.395
1990 Tanaka S, Currier SJ, Bruggemann EP, Ueda K, Germann UA, Pastan I, Gottesman MM. Use of recombinant P-glycoprotein fragments to produce antibodies to the multidrug transporter. Biochemical and Biophysical Research Communications. 166: 180-6. PMID 1967936 DOI: 10.1016/0006-291X(90)91928-L  0.319
1990 Thiebaut F, Currier SJ, Whitaker J, Haugland RP, Gottesman MM, Pastan I, Willingham MC. Activity of the multidrug transporter results in alkalinization of the cytosol: measurement of cytosolic pH by microinjection of a pH-sensitive dye. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 38: 685-90. PMID 1692055 DOI: 10.1177/38.5.1692055  0.388
1989 Gottesman MM, Pastan I. Resistance to multiple chemotherapeutic agents in human cancer cells. Trends in Pharmacological Sciences. 9: 54-8. PMID 3072730 DOI: 10.1016/0165-6147(88)90117-4  0.412
1989 Richert ND, Aldwin L, Nitecki D, Gottesman MM, Pastan I. Stability and covalent modification of P-glycoprotein in multidrug-resistant KB cells. Biochemistry. 27: 7607-13. PMID 2905169 DOI: 10.1021/Bi00420A006  0.419
1989 Lai SL, Goldstein LJ, Gottesman MM, Pastan I, Tsai CM, Johnson BE, Mulshine JL, Ihde DC, Kayser K, Gazdar AF. MDR1 gene expression in lung cancer. Journal of the National Cancer Institute. 81: 1144-50. PMID 2746668 DOI: 10.1093/Jnci/81.15.1144  0.376
1989 Kanamaru H, Kakehi Y, Yoshida O, Nakanishi S, Pastan I, Gottesman MM. MDR1 RNA levels in human renal cell carcinomas: Correlation with grade and prediction of reversal of doxorubicin resistance by quinidine in tumor explants Journal of the National Cancer Institute. 81: 844-849. PMID 2724349 DOI: 10.1093/Jnci/81.11.844  0.4
1989 Pirker R, Goldstein LJ, Ludwig H, Linkesch W, Lechner C, Gottesman MM, Pastan I. Expression of a multidrug resistance gene in blast crisis of chronic myelogenous leukemia Cancer Communications. 1: 141-144. PMID 2639725 DOI: 10.3727/095535489820875354  0.406
1989 Kioka N, Tsubota J, Kakehi Y, Komano T, Gottesman MM, Pastan I, Ueda K. P-glycoprotein gene (MDR1) cDNA from human adrenal: normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance. Biochemical and Biophysical Research Communications. 162: 224-31. PMID 2568832 DOI: 10.1016/0006-291X(89)91985-2  0.361
1989 Konen PL, Currier SJ, Rutherford AV, Gottesman MM, Pastan I, Willingham MC. The multidrug transporter: rapid modulation of efflux activity monitored in single cells by the morphologic effects of vinblastine and daunomycin. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 37: 1141-5. PMID 2567301 DOI: 10.1177/37.7.2567301  0.476
1989 Banker DE, Pastan I, Gottesman MM, Herschman HR. An epidermal growth factor-ricin A chain (EGF-RTA)-resistant mutant and an epidermal growth factor-Pseudomonas endotoxin (EGF-PE)-resistant mutant have distinct phenotypes. Journal of Cellular Physiology. 139: 51-7. PMID 2496133 DOI: 10.1002/Jcp.1041390109  0.342
1989 Smith SM, Kane SE, Gal S, Mason RW, Gottesman MM. Glycosylation of procathepsin L does not account for species molecular-mass differences and is not required for proteolytic activity Biochemical Journal. 262: 931-938. PMID 2480110  0.614
1988 Gal S, Gottesman MM. Isolation and sequence of a cDNA for human pro-(cathepsin L) Biochemical Journal. 253: 303-306. PMID 3421948 DOI: 10.1042/Bj2530303  0.603
1988 Horio M, Gottesman MM, Pastan I. ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells. Proceedings of the National Academy of Sciences of the United States of America. 85: 3580-4. PMID 3368466 DOI: 10.1073/Pnas.85.10.3580  0.49
1988 Amano F, Pastan I, Gottesman MM. Genetic characterization of human KB cell lines resistant to epidermal growth factor: Pseudomonas exotoxin conjugates. Journal of Cellular Physiology. 135: 527-32. PMID 3260900 DOI: 10.1002/jcp.1041350323  0.328
1988 Pastan I, Gottesman MM, Ueda K, Lovelace E, Rutherford AV, Willingham MC. A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells. Proceedings of the National Academy of Sciences of the United States of America. 85: 4486-90. PMID 2898143 DOI: 10.1073/Pnas.85.12.4486  0.477
1988 Chabner BA, Gottesman MM. Meeting highlights: William Guy Forbeck Foundation think tank on "multidrug resistance in cancer chemotherapy". Journal of the National Cancer Institute. 80: 391-4. PMID 2896799 DOI: 10.1093/Jnci/80.6.391  0.382
1988 Kane SE, Troen BR, Gal S, Ueda K, Pastan I, Gottesman MM. Use of cloned multidrug resistance gene for coamplification and overproduction of major excreted protein,a transformation-regulated secreted acid protease Molecular and Cellular Biology. 8: 3316-3321. PMID 2463474 DOI: 10.1128/Mcb.8.8.3316  0.693
1988 McCoy K, Gal S, Schwartz RH, Gottesman MM. An acid protease secreted by transformed cells interferes with antigen processing Journal of Cell Biology. 106: 1879-1884. PMID 2454929 DOI: 10.1083/Jcb.106.6.1879  0.654
1987 Whitfield C, Abraham I, Ascherman D, Gottesman MM. Transfer and amplification of a mutant beta-tubulin gene results in colcemid dependence: use of the transformant to demonstrate regulation of beta-tubulin subunit levels by protein degradation. Molecular and Cellular Biology. 6: 1422-9. PMID 3785170 DOI: 10.1128/Mcb.6.5.1422  0.328
1987 Troen BR, Gal S, Gottesman MM. Sequence and expression of the cDNA for MEP (major excreted protein), a transformation-regulated secreted cathepsin Biochemical Journal. 246: 731-735. PMID 3689328 DOI: 10.1042/Bj2460731  0.62
1987 Fojo AT, Shen DW, Mickley LA, Pastan I, Gottesman MM. Intrinsic drug resistance in human kidney cancer is associated with expression of a human multidrug-resistance gene. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 5: 1922-7. PMID 3681376 DOI: 10.1200/Jco.1987.5.12.1922  0.478
1987 Thorgeirsson SS, Huber BE, Sorrell S, Fojo A, Pastan I, Gottesman MM. Expression of the multidrug-resistant gene in hepatocarcinogenesis and regenerating rat liver. Science (New York, N.Y.). 236: 1120-2. PMID 3576227 DOI: 10.1126/Science.3576227  0.353
1987 FitzGerald DJ, Willingham MC, Cardarelli CO, Hamada H, Tsuruo T, Gottesman MM, Pastan I. A monoclonal antibody-Pseudomonas toxin conjugate that specifically kills multidrug-resistant cells. Proceedings of the National Academy of Sciences of the United States of America. 84: 4288-92. PMID 3495806 DOI: 10.1073/Pnas.84.12.4288  0.459
1987 Ueda K, Cardarelli C, Gottesman MM, Pastan I. Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine. Proceedings of the National Academy of Sciences of the United States of America. 84: 3004-8. PMID 3472246 DOI: 10.1073/Pnas.84.9.3004  0.468
1987 Mason RW, Gal S, Gottesman MM. The identification of the major excreted protein (MEP) from a transformed mouse fibroblast cell line as a catalytically active precursor form of cathepsin L Biochemical Journal. 248: 449-454. PMID 3435459 DOI: 10.1042/Bj2480449  0.6
1987 Aszalos A, Damjanovich S, Gottesman MM. Depolymerization of microtubules alters membrane potential and affects the motional freedom of membrane proteins. Biochemistry. 25: 5804-9. PMID 3022804 DOI: 10.1021/Bi00367A069  0.357
1987 Willingham MC, Richert ND, Cornwell MM, Tsuruo T, Hamada H, Gottesman MM, Pastan IH. Immunocytochemical localization of P170 at the plasma membrane of multidrug-resistant human cells. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 35: 1451-6. PMID 2890686 DOI: 10.1177/35.12.2890686  0.419
1987 Cornwell MM, Tsuruo T, Gottesman MM, Pastan I. ATP-binding properties of P glycoprotein from multidrug-resistant KB cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 1: 51-4. PMID 2886389 DOI: 10.1096/Fasebj.1.1.2886389  0.418
1987 Abraham I, Hunter RJ, Sampson KE, Smith S, Gottesman MM, Mayo JK. Cyclic AMP-dependent protein kinase regulates sensitivity of cells to multiple drugs Molecular and Cellular Biology. 7: 3098-3106. PMID 2823117 DOI: 10.1128/Mcb.7.9.3098  0.437
1987 Fojo AT, Ueda K, Slamon DJ, Poplack DG, Gottesman MM, Pastan I. Expression of a multidrug-resistance gene in human tumors and tissues. Proceedings of the National Academy of Sciences of the United States of America. 84: 265-9. PMID 2432605 DOI: 10.1073/Pnas.84.1.265  0.373
1986 Shen DW, Fojo A, Roninson IB, Chin JE, Soffir R, Pastan I, Gottesman MM. Multidrug resistance of DNA-mediated transformants is linked to transfer of the human mdr1 gene. Molecular and Cellular Biology. 6: 4039-45. PMID 3796599 DOI: 10.1128/Mcb.6.11.4039  0.462
1986 Gal S, Gottesman MM. The major excreted protein (MEP) of transformed mouse cells and cathepsin L have similar protease specificity Biochemical and Biophysical Research Communications. 139: 156-162. PMID 3533059 DOI: 10.1016/S0006-291X(86)80093-6  0.612
1986 Gal S, Gottesman MM. The major excreted protein of transformed fibroblasts is an activable acid-protease Journal of Biological Chemistry. 261: 1760-1765. PMID 3511049  0.62
1986 Roninson IB, Chin JE, Choi KG, Gros P, Housman DE, Fojo A, Shen DW, Gottesman MM, Pastan I. Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells. Proceedings of the National Academy of Sciences of the United States of America. 83: 4538-42. PMID 3459187 DOI: 10.1073/Pnas.83.12.4538  0.472
1986 Cornwell MM, Safa AR, Felsted RL, Gottesman MM, Pastan I. Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150- to 170-kDa protein detected by photoaffinity labeling. Proceedings of the National Academy of Sciences of the United States of America. 83: 3847-50. PMID 3459160 DOI: 10.1073/Pnas.83.11.3847  0.465
1986 Shen DW, Fojo A, Chin JE, Roninson IB, Richert N, Pastan I, Gottesman MM. Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification. Science (New York, N.Y.). 232: 643-5. PMID 3457471 DOI: 10.1126/science.3457471  0.37
1986 Ueda K, Cornwell MM, Gottesman MM, Pastan I, Roninson IB, Ling V, Riordan JR. The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein. Biochemical and Biophysical Research Communications. 141: 956-62. PMID 2880583 DOI: 10.1016/S0006-291X(86)80136-X  0.378
1985 Gottesman MM, Roth C, Vlahakis G, Pastan I. Cholera toxin treatment stimulates tumorigenicity of Rous sarcoma virus-transformed cells. Molecular and Cellular Biology. 4: 2639-42. PMID 6098816 DOI: 10.1128/Mcb.4.12.2639  0.307
1985 Doherty PJ, Hua L, Liau G, Gal S, Graham DE, Sobel M, Gottesman MM. Malignant transformation and tumor promoter treatment increase levels of a transcript for a secreted glycoprotein Molecular and Cellular Biology. 5: 466-473. PMID 3990681  0.585
1985 Gal S, Willingham MC, Gottesman MM. Processing and lysosomal localization of a glycoprotein whose secretion is transformation stimulated Journal of Cell Biology. 100: 535-544. PMID 3968177 DOI: 10.1083/Jcb.100.2.535  0.669
1985 Fojo AT, Whang-Peng J, Gottesman MM, Pastan I. Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells. Proceedings of the National Academy of Sciences of the United States of America. 82: 7661-5. PMID 3865187 DOI: 10.1073/Pnas.82.22.7661  0.415
1985 Richert N, Akiyama S, Shen D, Gottesman MM, Pastan I. Multiply drug-resistant human KB carcinoma cells have decreased amounts of a 75-kDa and a 72-kDa glycoprotein. Proceedings of the National Academy of Sciences of the United States of America. 82: 2330-3. PMID 3857583 DOI: 10.1073/Pnas.82.8.2330  0.472
1985 Akiyama Si, Fojo A, Hanover JA, Pastan I, Gottesman MM. Isolation and genetic characterization of human KB cell lines resistant to multiple drugs Somatic Cell and Molecular Genetics. 11: 117-126. PMID 3856953 DOI: 10.1007/BF01534700  0.372
1984 Hochman J, Levy E, Mador N, Gottesman MM, Shearer GM, Okon E. Cell adhesiveness is related to tumorigenicity in malignant lymphoid cells. The Journal of Cell Biology. 99: 1282-8. PMID 6480692 DOI: 10.1083/Jcb.99.4.1282  0.345
1983 Abraham I, Marcus M, Cabral F, Gottesman MM. Mutations in alpha- and beta-tubulin affect spindle formation in Chinese hamster ovary cells. The Journal of Cell Biology. 97: 1055-61. PMID 6619186 DOI: 10.1083/Jcb.97.4.1055  0.316
1981 Cabral F, Abraham I, Gottesman MM. Isolation of a taxol-resistant Chinese hamster ovary cell mutant that has an alteration in alpha-tubulin. Proceedings of the National Academy of Sciences of the United States of America. 78: 4388-91. PMID 6117076 DOI: 10.1073/Pnas.78.7.4388  0.373
1980 Cabral F, Willingham MC, Gottesman MM. Ultrastructural localization to 10 nm filaments of an insoluble 58K protein in cultured fibroblasts. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 28: 653-62. PMID 7391554 DOI: 10.1177/28.7.7391554  0.31
1980 Rabin MS, Gottesman MM. High frequency of mutation to tubercidin resistance in CHO cells. Somatic Cell Genetics. 5: 571-83. PMID 294700 DOI: 10.1007/BF01542695  0.302
1973 Gottesman MM, Hicks ML, Gellert M. Genetics and function of DNA ligase in Escherichia coli. Journal of Molecular Biology. 77: 531-47. PMID 4353284 DOI: 10.1016/0022-2836(73)90221-0  0.527
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