Year |
Citation |
Score |
2024 |
Wang Y, Hollingsworth LR, Sangaré LO, Paredes-Santos TC, Krishnamurthy S, Penn BH, Wu H, Saeij JPJ. Host E3 ubiquitin ligase ITCH mediates effector GRA35-triggered NLRP1 inflammasome activation and cell-autonomous immunity. Mbio. e0330223. PMID 38376248 DOI: 10.1128/mbio.03302-23 |
0.434 |
|
2023 |
Wang Y, Hollingsworth LR, Sangaré LO, Paredes-Santos TC, Krishnamurthy S, Penn BH, Wu H, Saeij JPJ. Host E3 ubiquitin ligase ITCH mediates effector GRA35-triggered NLRP1 inflammasome activation and cell-autonomous immunity. Biorxiv : the Preprint Server For Biology. PMID 38168400 DOI: 10.1101/2023.12.13.571530 |
0.83 |
|
2023 |
Bitew MA, Gaete PS, Swale C, Maru P, Contreras JE, Saeij JPJ. GRA47 and GRA72 are pore-forming proteins that influence small molecule permeability of the parasitophorous vacuole. Biorxiv : the Preprint Server For Biology. PMID 38014337 DOI: 10.1101/2023.11.15.567216 |
0.801 |
|
2023 |
Paredes-Santos TC, Bitew MA, Swale C, Rodriguez F, Krishnamurthy S, Wang Y, Maru P, Sangaré LO, Saeij JPJ. Genome-wide CRISPR screen identifies genes synthetically lethal with GRA17, a nutrient channel encoding gene in Toxoplasma. Plos Pathogens. 19: e1011543. PMID 37498952 DOI: 10.1371/journal.ppat.1011543 |
0.798 |
|
2023 |
Krishnamurthy S, Maru P, Wang Y, Bitew MA, Mukhopadhyay D, Yamaryo-Botté Y, Paredes-Santos TC, Sangaré LO, Swale C, Botté CY, Saeij JPJ. CRISPR Screens Identify Genes That Determine Parasite Fitness in Interferon Gamma-Stimulated Human Cells. Mbio. e0006023. PMID 36916910 DOI: 10.1128/mbio.00060-23 |
0.795 |
|
2023 |
Gonzales-Viera O, Arranz-Solís D, Smith J, Saeij JPJ, Mete A. Fatal Sarcocystis calchasi hepatitis in a captive Indian ringneck parakeet (Psittacula krameri manillensis). Veterinary Parasitology, Regional Studies and Reports. 39: 100841. PMID 36878626 DOI: 10.1016/j.vprsr.2023.100841 |
0.722 |
|
2023 |
Arranz-Solís D, Warschkau D, Fabian BT, Seeber F, Saeij JPJ. Late Embryogenesis Abundant Proteins Contribute to the Resistance of Toxoplasma gondii Oocysts against Environmental Stresses. Mbio. e0286822. PMID 36809045 DOI: 10.1128/mbio.02868-22 |
0.758 |
|
2022 |
Ten Hoeve AL, Braun L, Rodriguez ME, Olivera GC, Bougdour A, Belmudes L, Couté Y, Saeij JPJ, Hakimi MA, Barragan A. The Toxoplasma effector GRA28 promotes parasite dissemination by inducing dendritic cell-like migratory properties in infected macrophages. Cell Host & Microbe. 30: 1570-1588.e7. PMID 36309013 DOI: 10.1016/j.chom.2022.10.001 |
0.413 |
|
2022 |
Rico-San Román L, Amieva R, Regidor-Cerrillo J, García-Sánchez M, Collantes-Fernández E, Pastor-Fernández I, Saeij JPJ, Ortega-Mora LM, Horcajo P. Nc and Nc Play a Role in the Virulence of in a Pregnant Mouse Model. Pathogens (Basel, Switzerland). 11. PMID 36145430 DOI: 10.3390/pathogens11090998 |
0.379 |
|
2022 |
Ross EC, Hoeve ALT, Saeij JPJ, Barragan A. effector-induced ICAM-1 expression by infected dendritic cells potentiates transmigration across polarised endothelium. Frontiers in Immunology. 13: 950914. PMID 35990682 DOI: 10.3389/fimmu.2022.950914 |
0.352 |
|
2022 |
Arranz-Solís D, Saeij JPJ. New Avenues to Design Vaccines Based on Oocysts and Cysts. Frontiers in Immunology. 13: 910961. PMID 35734184 DOI: 10.3389/fimmu.2022.910961 |
0.737 |
|
2022 |
Rogers KH, Arranz-Solís D, Saeij JPJ, Lewis S, Mete A. and other Sarcocystidae detected in predatory birds in California, USA. International Journal For Parasitology. Parasites and Wildlife. 17: 91-99. PMID 35004169 DOI: 10.1016/j.ijppaw.2021.12.008 |
0.764 |
|
2021 |
Glausen TG, Carrillo GL, Jin RM, Boyle JP, Saeij JPJ, Wohlfert EA, Fox MA, Blader IJ. The Polymorphic Effector GRA15 Mediates Seizure Induction by Modulating Interleukin-1 Signaling in the Brain. Mbio. e0133121. PMID 34154412 DOI: 10.1128/mBio.01331-21 |
0.77 |
|
2021 |
Sangaré LO, Wang Y, Arranz-Solís D, Saeij JPJ. CRISPR screen to determine the fitness of genes. Star Protocols. 2: 100520. PMID 34013213 DOI: 10.1016/j.xpro.2021.100520 |
0.82 |
|
2021 |
Tomita T, Mukhopadhyay D, Han B, Yakubu R, Tu V, Mayoral J, Sugi T, Ma Y, Saeij JPJ, Weiss LM. Toxoplasma gondii Matrix Antigen 1 Is a Secreted Immunomodulatory Effector. Mbio. 12. PMID 34006649 DOI: 10.1128/mBio.00603-21 |
0.796 |
|
2021 |
Arranz-Solís D, Carvalheiro CG, Zhang ER, Grigg ME, Saeij JPJ. GRA Peptide-Specific Serologic Fingerprints Discriminate Among Major Strains Causing Toxoplasmosis. Frontiers in Cellular and Infection Microbiology. 11: 621738. PMID 33680990 DOI: 10.3389/fcimb.2021.621738 |
0.729 |
|
2020 |
Arranz-Solís D, Mukhopadhyay D, Saeij JJP. Toxoplasma Effectors that Affect Pregnancy Outcome. Trends in Parasitology. PMID 33234405 DOI: 10.1016/j.pt.2020.10.013 |
0.835 |
|
2020 |
Mukhopadhyay D, Arranz-Solís D, Saeij JPJ. Influence of the Host and Parasite Strain on the Immune Response During Infection. Frontiers in Cellular and Infection Microbiology. 10: 580425. PMID 33178630 DOI: 10.3389/fcimb.2020.580425 |
0.845 |
|
2020 |
Wang Y, Sangaré LO, Paredes-Santos TC, Hassan MA, Krishnamurthy S, Furuta AM, Markus BM, Lourido S, Saeij JPJ. Genome-wide screens identify Toxoplasma gondii determinants of parasite fitness in IFNγ-activated murine macrophages. Nature Communications. 11: 5258. PMID 33067458 DOI: 10.1038/s41467-020-18991-8 |
0.837 |
|
2020 |
Kongsomboonvech AK, Rodriguez F, Diep AL, Justice BM, Castallanos BE, Camejo A, Mukhopadhyay D, Taylor GA, Yamamoto M, Saeij JPJ, Reese ML, Jensen KDC. Naïve CD8 T cell IFNγ responses to a vacuolar antigen are regulated by an inflammasome-independent NLRP3 pathway and Toxoplasma gondii ROP5. Plos Pathogens. 16: e1008327. PMID 32853276 DOI: 10.1371/Journal.Ppat.1008327 |
0.825 |
|
2020 |
Wang Y, Sangaré LO, Paredes-Santos TC, Saeij JPJ. Mechanisms for Delivery of Proteins and Uptake of Nutrients Across the Host-Pathogen Interface. Annual Review of Microbiology. PMID 32680452 DOI: 10.1146/annurev-micro-011720-122318 |
0.832 |
|
2020 |
Bamac OE, Rogers KH, Arranz-Solís D, Saeij JPJ, Lewis S, Duerr R, Skoglund J, Peronne L, Mete A. Protozoal encephalitis associated with and during an epizootic involving Brandt's cormorants () in coastal Southern California, USA. International Journal For Parasitology. Parasites and Wildlife. 12: 185-191. PMID 32617260 DOI: 10.1016/j.ijppaw.2020.06.005 |
0.757 |
|
2020 |
Mukhopadhyay D, Arranz-Solís D, Saeij JPJ. Toxoplasma GRA15 and GRA24 are important activators of the host innate immune response in the absence of TLR11. Plos Pathogens. 16: e1008586. PMID 32453782 DOI: 10.1371/journal.ppat.1008586 |
0.816 |
|
2020 |
Rico-San Román L, Horcajo P, Regidor-Cerrillo J, Fernández-Escobar M, Collantes-Fernández E, Gutiérrez-Blázquez D, Hernáez-Sánchez ML, Saeij JPJ, Ortega-Mora LM. Comparative tachyzoite proteome analyses among six Neospora caninum isolates with different virulence. International Journal For Parasitology. PMID 32360428 DOI: 10.1016/j.ijpara.2020.02.003 |
0.339 |
|
2020 |
Mukhopadhyay D, Sangaré LO, Braun L, Hakimi MA, Saeij JP. Toxoplasma GRA15 limits parasite growth in IFNγ-activated fibroblasts through TRAF ubiquitin ligases. The Embo Journal. e103758. PMID 32293748 DOI: 10.15252/embj.2019103758 |
0.841 |
|
2020 |
Waldman BS, Schwarz D, Wadsworth MH, Saeij JP, Shalek AK, Lourido S. Identification of a Master Regulator of Differentiation in Toxoplasma. Cell. 180: 359-372.e16. PMID 31955846 DOI: 10.1016/J.Cell.2019.12.013 |
0.395 |
|
2020 |
Mukhopadhyay D, Saeij JPJ. Assays to Evaluate Toxoplasma-Macrophage Interactions. Methods in Molecular Biology (Clifton, N.J.). 2071: 347-370. PMID 31758462 DOI: 10.1007/978-1-4939-9857-9_19 |
0.777 |
|
2019 |
Arranz-Solís D, Cordeiro C, Young LH, Dardé ML, Commodaro AG, Grigg ME, Saeij JPJ. Serotyping of Infection Using Peptide Membrane Arrays. Frontiers in Cellular and Infection Microbiology. 9: 408. PMID 31850240 DOI: 10.3389/fcimb.2019.00408 |
0.772 |
|
2019 |
Sangaré LO, Ólafsson EB, Wang Y, Yang N, Julien L, Camejo A, Pesavento P, Sidik SM, Lourido S, Barragan A, Saeij JPJ. In Vivo CRISPR Screen Identifies TgWIP as a Toxoplasma Modulator of Dendritic Cell Migration. Cell Host & Microbe. 26: 478-492.e8. PMID 31600500 DOI: 10.1016/J.Chom.2019.09.008 |
0.81 |
|
2019 |
Paredes-Santos T, Wang Y, Waldman B, Lourido S, Saeij JP. The GRA17 Parasitophorous Vacuole Membrane Permeability Pore Contributes to Bradyzoite Viability. Frontiers in Cellular and Infection Microbiology. 9: 321. PMID 31572690 DOI: 10.3389/Fcimb.2019.00321 |
0.601 |
|
2019 |
Sangaré LO, Yang N, Konstantinou EK, Lu D, Mukhopadhyay D, Young LH, Saeij JPJ. GRA15 Activates the NF-κB Pathway through Interactions with TNF Receptor-Associated Factors. Mbio. 10. PMID 31311877 DOI: 10.1128/Mbio.00808-19 |
0.791 |
|
2019 |
Wang Y, Cirelli KM, Barros PDC, Sangaré LO, Butty V, Hassan MA, Pesavento P, Mete A, Saeij JPJ. Three Dense Granule Proteins Are Required for Induction of Lewis Rat Macrophage Pyroptosis. Mbio. 10. PMID 30622189 DOI: 10.1128/mBio.02388-18 |
0.81 |
|
2019 |
Hassan MA, Olijnik AA, Frickel EM, Saeij JP. Clonal and atypical Toxoplasma strain differences in virulence vary with mouse sub-species. International Journal For Parasitology. 49: 63-70. PMID 30471286 DOI: 10.1016/j.ijpara.2018.08.007 |
0.771 |
|
2018 |
Krishnamurthy S, Saeij JPJ. Does Not Secrete the GRA16 and GRA24 Effectors Beyond the Parasitophorous Vacuole Membrane of Tissue Cysts. Frontiers in Cellular and Infection Microbiology. 8: 366. PMID 30406043 DOI: 10.3389/fcimb.2018.00366 |
0.782 |
|
2018 |
Arranz-Solís D, Regidor-Cerrillo J, Lourido S, Ortega-Mora LM, Saeij JPJ. Toxoplasma CRISPR/Cas9 constructs are functional for gene disruption in Neospora caninum. International Journal For Parasitology. PMID 29625127 DOI: 10.1016/J.Ijpara.2018.03.002 |
0.784 |
|
2017 |
Saeij JP, Frickel EM. Exposing Toxoplasma gondii hiding inside the vacuole: a role for GBPs, autophagy and host cell death. Current Opinion in Microbiology. 40: 72-80. PMID 29141239 DOI: 10.1016/j.mib.2017.10.021 |
0.531 |
|
2017 |
Krishnamurthy S, Konstantinou EK, Young LH, Gold DA, Saeij JP. The human immune response to Toxoplasma: Autophagy versus cell death. Plos Pathogens. 13: e1006176. PMID 28278184 DOI: 10.1371/Journal.Ppat.1006176 |
0.79 |
|
2016 |
Sidik SM, Huet D, Ganesan SM, Huynh MH, Wang T, Nasamu AS, Thiru P, Saeij JP, Carruthers VB, Niles JC, Lourido S. A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Cell. PMID 27594426 DOI: 10.1016/J.Cell.2016.08.019 |
0.497 |
|
2016 |
Fink A, Hassan MA, Okan NA, Sheffer M, Camejo A, Saeij JP, Kasper DL. Early Interactions of Murine Macrophages with Francisella tularensis Map to Mouse Chromosome 19. Mbio. 7. PMID 26980837 DOI: 10.1128/Mbio.02243-15 |
0.765 |
|
2016 |
Lorenzi H, Khan A, Behnke MS, Namasivayam S, Swapna LS, Hadjithomas M, Karamycheva S, Pinney D, Brunk BP, Ajioka JW, Ajzenberg D, Boothroyd JC, Boyle JP, Dardé ML, Diaz-Miranda MA, ... ... Saeij JP, et al. Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes. Nature Communications. 7: 10147. PMID 26738725 DOI: 10.1038/Ncomms10147 |
0.74 |
|
2015 |
Hassan MA, Jensen KD, Butty V, Hu K, Boedec E, Prins P, Saeij JP. Transcriptional and Linkage Analyses Identify Loci that Mediate the Differential Macrophage Response to Inflammatory Stimuli and Infection. Plos Genetics. 11: e1005619. PMID 26510153 DOI: 10.1371/Journal.Pgen.1005619 |
0.811 |
|
2015 |
Gold DA, Kaplan AD, Lis A, Bett GC, Rosowski EE, Cirelli KM, Bougdour A, Sidik SM, Beck JR, Lourido S, Egea PF, Bradley PJ, Hakimi MA, Rasmusson RL, Saeij JP. The Toxoplasma Dense Granule Proteins GRA17 and GRA23 Mediate the Movement of Small Molecules between the Host and the Parasitophorous Vacuole. Cell Host & Microbe. 17: 642-52. PMID 25974303 DOI: 10.1016/J.Chom.2015.04.003 |
0.808 |
|
2015 |
Jensen KD, Camejo A, Melo MB, Cordeiro C, Julien L, Grotenbreg GM, Frickel EM, Ploegh HL, Young L, Saeij JP. Toxoplasma gondii superinfection and virulence during secondary infection correlate with the exact ROP5/ROP18 allelic combination. Mbio. 6: e02280. PMID 25714710 DOI: 10.1128/Mbio.02280-14 |
0.83 |
|
2014 |
Hassan MA, Saeij JP. Incorporating alternative splicing and mRNA editing into the genetic analysis of complex traits. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 36: 1032-40. PMID 25171292 DOI: 10.1002/bies.201400079 |
0.713 |
|
2014 |
Murray PJ, Allen JE, Biswas SK, Fisher EA, Gilroy DW, Goerdt S, Gordon S, Hamilton JA, Ivashkiv LB, Lawrence T, Locati M, Mantovani A, Martinez FO, Mege JL, Mosser DM, ... ... Saeij JP, et al. Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity. 41: 14-20. PMID 25035950 DOI: 10.1016/J.Immuni.2014.06.008 |
0.3 |
|
2014 |
Cirelli KM, Gorfu G, Hassan MA, Printz M, Crown D, Leppla SH, Grigg ME, Saeij JP, Moayeri M. Inflammasome sensor NLRP1 controls rat macrophage susceptibility to Toxoplasma gondii. Plos Pathogens. 10: e1003927. PMID 24626226 DOI: 10.1371/Journal.Ppat.1003927 |
0.815 |
|
2014 |
Cannella D, Brenier-Pinchart MP, Braun L, van Rooyen JM, Bougdour A, Bastien O, Behnke MS, Curt RL, Curt A, Saeij JP, Sibley LD, Pelloux H, Hakimi MA. miR-146a and miR-155 delineate a MicroRNA fingerprint associated with Toxoplasma persistence in the host brain. Cell Reports. 6: 928-37. PMID 24582962 DOI: 10.1016/j.celrep.2014.02.002 |
0.552 |
|
2014 |
Gorfu G, Cirelli KM, Melo MB, Mayer-Barber K, Crown D, Koller BH, Masters S, Sher A, Leppla SH, Moayeri M, Saeij JP, Grigg ME. Dual role for inflammasome sensors NLRP1 and NLRP3 in murine resistance to Toxoplasma gondii. Mbio. 5. PMID 24549849 DOI: 10.1128/Mbio.01117-13 |
0.795 |
|
2014 |
Rosowski EE, Nguyen QP, Camejo A, Spooner E, Saeij JP. Toxoplasma gondii Inhibits gamma interferon (IFN-γ)- and IFN-β-induced host cell STAT1 transcriptional activity by increasing the association of STAT1 with DNA. Infection and Immunity. 82: 706-19. PMID 24478085 DOI: 10.1128/IAI.01291-13 |
0.8 |
|
2014 |
Hassan MA, Butty V, Jensen KD, Saeij JP. The genetic basis for individual differences in mRNA splicing and APOBEC1 editing activity in murine macrophages. Genome Research. 24: 377-89. PMID 24249727 DOI: 10.1101/gr.166033.113 |
0.784 |
|
2014 |
Camejo A, Gold DA, Lu D, McFetridge K, Julien L, Yang N, Jensen KD, Saeij JP. Identification of three novel Toxoplasma gondii rhoptry proteins. International Journal For Parasitology. 44: 147-60. PMID 24070999 DOI: 10.1016/J.Ijpara.2013.08.002 |
0.823 |
|
2014 |
Murray PJ, Allen JE, Biswas SK, Fisher EA, Gilroy DW, Goerdt S, Gordon S, Hamilton JA, Ivashkiv LB, Lawrence T, Locati M, Mantovani A, Martinez FO, Mege JL, Mosser DM, ... ... Saeij JP, et al. Correction tp Macrophage activation and polarization: Nomenclature and experimental guidelines [Immunity, 41, 2014 (14-20)] Immunity. 41: 339-340. DOI: 10.1016/J.Immuni.2014.07.009 |
0.318 |
|
2014 |
Hassan MA, Saeij JPJ. Incorporating alternative splicing and mRNA editing into the genetic analysis of complex traits Bioessays. 36: 1032-1040. DOI: 10.1002/bies.201400079 |
0.713 |
|
2013 |
Melo MB, Nguyen QP, Cordeiro C, Hassan MA, Yang N, McKell R, Rosowski EE, Julien L, Butty V, Dardé ML, Ajzenberg D, Fitzgerald K, Young LH, Saeij JP. Transcriptional analysis of murine macrophages infected with different Toxoplasma strains identifies novel regulation of host signaling pathways. Plos Pathogens. 9: e1003779. PMID 24367253 DOI: 10.1371/Journal.Ppat.1003779 |
0.831 |
|
2013 |
Lim D, Gold DA, Julien L, Rosowski EE, Niedelman W, Yaffe MB, Saeij JP. Structure of the Toxoplasma gondii ROP18 kinase domain reveals a second ligand binding pocket required for acute virulence. The Journal of Biological Chemistry. 288: 34968-80. PMID 24129568 DOI: 10.1074/Jbc.M113.523266 |
0.819 |
|
2013 |
Niedelman W, Sprokholt JK, Clough B, Frickel EM, Saeij JP. Cell death of gamma interferon-stimulated human fibroblasts upon Toxoplasma gondii infection induces early parasite egress and limits parasite replication. Infection and Immunity. 81: 4341-9. PMID 24042117 DOI: 10.1128/IAI.00416-13 |
0.478 |
|
2013 |
Yang N, Farrell A, Niedelman W, Melo M, Lu D, Julien L, Marth GT, Gubbels MJ, Saeij JP. Genetic basis for phenotypic differences between different Toxoplasma gondii type I strains. Bmc Genomics. 14: 467. PMID 23837824 DOI: 10.1186/1471-2164-14-467 |
0.823 |
|
2013 |
Jensen KD, Hu K, Whitmarsh RJ, Hassan MA, Julien L, Lu D, Chen L, Hunter CA, Saeij JP. Toxoplasma gondii rhoptry 16 kinase promotes host resistance to oral infection and intestinal inflammation only in the context of the dense granule protein GRA15. Infection and Immunity. 81: 2156-67. PMID 23545295 DOI: 10.1128/Iai.01185-12 |
0.846 |
|
2013 |
Lim D, Gold DA, Julien L, Rosowski EE, Niedelman W, Yaffe MB, Saeij JPJ. Structure of the toxoplasma gondii ROP18 kinase domain reveals a second ligand binding pocket required for acute virulence Journal of Biological Chemistry. 288: 34968-34980. DOI: 10.1074/jbc.M113.523266 |
0.764 |
|
2012 |
Rosowski EE, Saeij JP. Toxoplasma gondii clonal strains all inhibit STAT1 transcriptional activity but polymorphic effectors differentially modulate IFNγ induced gene expression and STAT1 phosphorylation. Plos One. 7: e51448. PMID 23240025 DOI: 10.1371/Journal.Pone.0051448 |
0.802 |
|
2012 |
Hassan MA, Melo MB, Haas B, Jensen KD, Saeij JP. De novo reconstruction of the Toxoplasma gondii transcriptome improves on the current genome annotation and reveals alternatively spliced transcripts and putative long non-coding RNAs. Bmc Genomics. 13: 696. PMID 23231500 DOI: 10.1186/1471-2164-13-696 |
0.788 |
|
2012 |
Minot S, Melo MB, Li F, Lu D, Niedelman W, Levine SS, Saeij JP. Admixture and recombination among Toxoplasma gondii lineages explain global genome diversity. Proceedings of the National Academy of Sciences of the United States of America. 109: 13458-63. PMID 22847430 DOI: 10.1073/Pnas.1117047109 |
0.812 |
|
2012 |
Niedelman W, Gold DA, Rosowski EE, Sprokholt JK, Lim D, Arenas AF, Melo MB, Spooner E, Yaffe MB, Saeij JPJ. The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response Plos Pathogens. 8. PMID 22761577 DOI: 10.1371/Journal.Ppat.1002784 |
0.836 |
|
2012 |
Szatanek T, Anderson-White BR, Faugno-Fusci DM, White M, Saeij JP, Gubbels MJ. Cactin is essential for G1 progression in Toxoplasma gondii. Molecular Microbiology. 84: 566-77. PMID 22486860 DOI: 10.1111/J.1365-2958.2012.08044.X |
0.445 |
|
2012 |
Lim DC, Cooke BM, Doerig C, Saeij JP. Toxoplasma and Plasmodium protein kinases: roles in invasion and host cell remodelling. International Journal For Parasitology. 42: 21-32. PMID 22154850 DOI: 10.1016/j.ijpara.2011.11.007 |
0.412 |
|
2011 |
Virreira Winter S, Niedelman W, Jensen KD, Rosowski EE, Julien L, Spooner E, Caradonna K, Burleigh BA, Saeij JP, Ploegh HL, Frickel EM. Determinants of GBP recruitment to Toxoplasma gondii vacuoles and the parasitic factors that control it. Plos One. 6: e24434. PMID 21931713 DOI: 10.1371/Journal.Pone.0024434 |
0.846 |
|
2011 |
Melo MB, Jensen KD, Saeij JP. Toxoplasma gondii effectors are master regulators of the inflammatory response. Trends in Parasitology. 27: 487-95. PMID 21893432 DOI: 10.1016/J.Pt.2011.08.001 |
0.844 |
|
2011 |
Jensen KD, Wang Y, Wojno ED, Shastri AJ, Hu K, Cornel L, Boedec E, Ong YC, Chien YH, Hunter CA, Boothroyd JC, Saeij JP. Toxoplasma polymorphic effectors determine macrophage polarization and intestinal inflammation. Cell Host & Microbe. 9: 472-83. PMID 21669396 DOI: 10.1016/J.Chom.2011.04.015 |
0.837 |
|
2011 |
Reese ML, Zeiner GM, Saeij JP, Boothroyd JC, Boyle JP. Polymorphic family of injected pseudokinases is paramount in Toxoplasma virulence. Proceedings of the National Academy of Sciences of the United States of America. 108: 9625-30. PMID 21436047 DOI: 10.1073/Pnas.1015980108 |
0.774 |
|
2011 |
Rosowski EE, Lu D, Julien L, Rodda L, Gaiser RA, Jensen KD, Saeij JP. Strain-specific activation of the NF-kappaB pathway by GRA15, a novel Toxoplasma gondii dense granule protein. The Journal of Experimental Medicine. 208: 195-212. PMID 21199955 DOI: 10.1084/Jem.20100717 |
0.823 |
|
2009 |
Blader IJ, Saeij JP. Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulence. Apmis : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. 117: 458-76. PMID 19400868 DOI: 10.1111/j.1600-0463.2009.02453.x |
0.754 |
|
2008 |
Boyle JP, Saeij JP, Harada SY, Ajioka JW, Boothroyd JC. Expression quantitative trait locus mapping of toxoplasma genes reveals multiple mechanisms for strain-specific differences in gene expression. Eukaryotic Cell. 7: 1403-14. PMID 18552283 DOI: 10.1128/Ec.00073-08 |
0.714 |
|
2008 |
Saeij JP, Arrizabalaga G, Boothroyd JC. A cluster of four surface antigen genes specifically expressed in bradyzoites, SAG2CDXY, plays an important role in Toxoplasma gondii persistence. Infection and Immunity. 76: 2402-10. PMID 18347037 DOI: 10.1128/Iai.01494-07 |
0.632 |
|
2007 |
Boyle JP, Saeij JP, Boothroyd JC. Toxoplasma gondii: inconsistent dissemination patterns following oral infection in mice. Experimental Parasitology. 116: 302-5. PMID 17335814 DOI: 10.1016/J.Exppara.2007.01.010 |
0.704 |
|
2007 |
Saeij JP, Coller S, Boyle JP, Jerome ME, White MW, Boothroyd JC. Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue. Nature. 445: 324-7. PMID 17183270 DOI: 10.1038/Nature05395 |
0.802 |
|
2006 |
Saeij JP, Boyle JP, Coller S, Taylor S, Sibley LD, Brooke-Powell ET, Ajioka JW, Boothroyd JC. Polymorphic secreted kinases are key virulence factors in toxoplasmosis. Science (New York, N.Y.). 314: 1780-3. PMID 17170306 DOI: 10.1126/Science.1133690 |
0.813 |
|
2006 |
Boyle JP, Rajasekar B, Saeij JP, Ajioka JW, Berriman M, Paulsen I, Roos DS, Sibley LD, White MW, Boothroyd JC. Just one cross appears capable of dramatically altering the population biology of a eukaryotic pathogen like Toxoplasma gondii. Proceedings of the National Academy of Sciences of the United States of America. 103: 10514-9. PMID 16801557 DOI: 10.1073/Pnas.0510319103 |
0.771 |
|
2006 |
Boyle JP, Saeij JP, Cleary MD, Boothroyd JC. Analysis of gene expression during development: lessons from the Apicomplexa. Microbes and Infection / Institut Pasteur. 8: 1623-30. PMID 16697685 DOI: 10.1016/J.Micinf.2005.11.017 |
0.798 |
|
2006 |
Huttenhuis HBT, Taverne-Thiele AJ, Grou CPO, Bergsma J, Saeij JPJ, Nakayasu C, Rombout JHWM. Ontogeny of the common carp (Cyprinus carpio L.) innate immune system Developmental and Comparative Immunology. 30: 557-574. PMID 16406121 DOI: 10.1016/j.dci.2005.08.001 |
0.343 |
|
2005 |
Saeij JP, Boyle JP, Boothroyd JC. Differences among the three major strains of Toxoplasma gondii and their specific interactions with the infected host. Trends in Parasitology. 21: 476-81. PMID 16098810 DOI: 10.1016/J.Pt.2005.08.001 |
0.76 |
|
2005 |
Saeij JP, Boyle JP, Grigg ME, Arrizabalaga G, Boothroyd JC. Bioluminescence imaging of Toxoplasma gondii infection in living mice reveals dramatic differences between strains. Infection and Immunity. 73: 695-702. PMID 15664907 DOI: 10.1128/Iai.73.2.695-702.2005 |
0.731 |
|
2004 |
Joerink M, Saeij JPJ, Stafford JL, Belosevic M, Wiegertjes GF. Animal models for the study of innate immunity: protozoan infections in fish Symposia of the Society For Experimental Biology. PMID 15446445 |
0.38 |
|
2003 |
Saeij JP, Groeneveld A, Van Rooijen N, Haenen OL, Wiegertjes GF. Minor effect of depletion of resident macrophages from peritoneal cavity on resistance of common carp Cyprinus carpio to blood flagellates. Diseases of Aquatic Organisms. 57: 67-75. PMID 14735923 DOI: 10.3354/dao057067 |
0.391 |
|
2003 |
Engelsma MY, Stet RJ, Saeij JP, Verburg-van Kemenade BM. Differential expression and haplotypic variation of two interleukin-1beta genes in the common carp (Cyprinus carpio L.). Cytokine. 22: 21-32. PMID 12946102 |
0.242 |
|
2003 |
Saeij JP, de Vries BJ, Wiegertjes GF. The immune response of carp to Trypanoplasma borreli: kinetics of immune gene expression and polyclonal lymphocyte activation. Developmental and Comparative Immunology. 27: 859-74. PMID 12880636 |
0.413 |
|
2003 |
Saeij JP, van Muiswinkel WB, van de Meent M, Amaral C, Wiegertjes GF. Different capacities of carp leukocytes to encounter nitric oxide-mediated stress: a role for the intracellular reduced glutathione pool. Developmental and Comparative Immunology. 27: 555-68. PMID 12697312 |
0.306 |
|
2003 |
Saeij JP, Verburg-van Kemenade LB, van Muiswinkel WB, Wiegertjes GF. Daily handling stress reduces resistance of carp to Trypanoplasma borreli: in vitro modulatory effects of cortisol on leukocyte function and apoptosis. Developmental and Comparative Immunology. 27: 233-45. PMID 12590974 |
0.317 |
|
2003 |
Saeij JP, Stet RJ, de Vries BJ, van Muiswinkel WB, Wiegertjes GF. Molecular and functional characterization of carp TNF: a link between TNF polymorphism and trypanotolerance? Developmental and Comparative Immunology. 27: 29-41. PMID 12477499 |
0.297 |
|
2002 |
Saeij J, Muiswinkel WBV, Groeneveld A, Wiegertjes GF. Immune modulation by fish kinetoplastid parasites: a role for nitric oxide. Parasitology. 124: 77-86. PMID 11817378 DOI: 10.1017/S0031182001008915 |
0.513 |
|
2000 |
Saeij JP, Stet RJ, Groeneveld A, Verburg-van Kemenade LB, van Muiswinkel WB, Wiegertjes GF. Molecular and functional characterization of a fish inducible-type nitric oxide synthase. Immunogenetics. 51: 339-46. PMID 10803847 DOI: 10.1007/s002510050628 |
0.317 |
|
1999 |
Saeij JP, Wiegertjes GF, Stet RJ. Identification and characterization of a fish natural resistance-associated macrophage protein (NRAMP) cDNA. Immunogenetics. 50: 60-6. PMID 10541807 DOI: 10.1007/s002510050686 |
0.354 |
|
1999 |
Stet RJ, Kruiswijk CP, Saeij JP, Wiegertjes GF. Major histocompatibility genes in cyprinid fishes: theory and practice. Immunological Reviews. 166: 301-16. PMID 9914921 DOI: 10.1111/j.1600-065x.1998.tb01271.x |
0.287 |
|
1998 |
Verburg-Van Kemenade BM, Saeij JP, Flik G, Willems PH. Ca2+ signals during early lymphocyte activation in carp Cyprinus carpio L. The Journal of Experimental Biology. 201: 591-8. PMID 9438833 DOI: 10.1242/jeb.201.4.591 |
0.259 |
|
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